Search

Your search keyword '"G.J. den Ottolander"' showing total 8 results
Start Over Author "G.J. den Ottolander"
8 results on '"G.J. den Ottolander"'

1. [Untitled]

Author

G.J. den Ottolander, H.L.K. Janssen, J.M. van Laar, B. van Hoek, J.H.J.M. van Krieken, and Ferdinand C. Breedveld

Subjects
Hepatitis, medicine.medical_specialty, Adult Still's disease, Physiology, business.industry, Anemia, Gastroenterology, Pure red cell aplasia, Still Disease, Hepatology, medicine.disease, Prednisone, Internal medicine, Immunology, medicine, Aplastic anemia, business, medicine.drug
Abstract

Adult-onset Still's disease is a systemic inflammatory disorder with a highly variable clinical course. Mild hepatitis and anemia are common manifestations. We describe a patient with adult Still's disease who developed a severe hepatitis and a life-threatening pure red cell aplasia. The hepatitis developed after treatment with NSAIDs was started. The patient was successfully treated with a combination of prednisone, cyclosporin, and methotrexate. Physicians should be aware that severe hepatitis and pure red cell aplasia can occur in adult Still's disease. We recommend a careful monitoring of liver functions in patients with adult Still's disease who are being treated with NSAIDs.

Published
1999
Full Text
View/download PDF

2. t(5;12)(q31;p12) A clinical entity with features of both myeloid leukemia and chronic myelomonocytic leukemia

Author

K.J. Roozendaal, J. E. Landegent, D. van der Keur, G.J. den Ottolander, Geoffrey C. Beverstock, J. W. Wessels, W. E. Fibbe, and D. C. van der Plas

Subjects
Adult, Male, congenital, hereditary, and neonatal diseases and abnormalities, Cancer Research, medicine.medical_specialty, Myelomonocytic leukemia, Chronic myelomonocytic leukemia, Chromosomal translocation, Disease, Biology, Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative, Translocation, Genetic, hemic and lymphatic diseases, Genetics, medicine, Humans, Molecular Biology, Southern blot, Chromosomes, Human, Pair 12, Cytogenetics, Myeloid leukemia, Leukemia, Myelomonocytic, Chronic, Karyotype, Middle Aged, medicine.disease, Blotting, Southern, Karyotyping, Immunology, Chromosomes, Human, Pair 5
Abstract

We report two patients with a myeloproliferative disorder (Philadelphia chromosome-negative chronic myeloid leukemia) and t(5;12)(q31;p12). Until now, only three cases of a translocation (5;12)(q31;p12) have been reported. All investigators had problems classifying their patient's disease into one of the well-defined entities of either MPD or myelodysplastic disorders. We postulate that this translocation may represent a subgroup of patients with features of both chronic myeloid leukemia and chronic myelomonocytic leukemia (CMMoL).

Published
1993
Full Text
View/download PDF

3. Title Page / Table of Contents / Abstracts

Author

A. Kumamoto, Rosalyn Slater, A. Geurts van Kessel, J.W. Wessels, B.M. Cattanach, E.J. Dreef, R.E. Kibbelaar, G. Otulakowski, Charles E. Schwartz, S. Parikh, G.J. den Ottolander, J. George, I. Hansmann, U. Francke, G.M. Greig, H. Nakai, M.G. Byers, F. Yang, S. Boularand, Roger E. Stevenson, N.S.-F. Ma, J. Hayakawa, L.-C. Tsui, D.W. Threadgill, S. Kubota, D.H. Ledbetter, J. Spencer, I.A. Noordermeer, D.B. Farber, T.B. Nesterova, J.E. Womack, C.A. Kozak, L. Shi, C. Collet, M.C. Phelan, M. Vercruyssen, W.E. Fibbe, J. Mallet, H.F. Willard, E.P. Evans, C. Hanson, R.G. Taylor, N.B. Rubtsov, L.T. Williams, Andries Westerveld, R.G. Lafreniere, S. Navankasattusas, C. Szpirer, C.-L. Hsieh, C. Rasberry, E. Solomon, M.A. Abruzzo, M. Rivière, D.S. Gerhard, J.A. Escobedo, S.I. Radjabli, S.W. Scherer, D. Sheer, I.V. Nikitina, R.H. Brakenhoff, J.A. Miller, T.A. Jones, K.I. Kivirikko, T.J.M. Hulsebos, R.R. Mclnnes, T. Koizumi, M.C. Darmon, A. Goddard, P. Stanislovitis, S.P. Craig, N.J. Nowak, V.E. Powers, M.C. Simmler, S.M. Zakian, Y. Nakai, A.C.B. Peters, M. Kimura, J. Szpirer, M. Danciger, L. Dandolo, M. Westerman, M. van der Ploeg, L. Pajunen, E.P.J. Arnoldus, A.K. Raap, G.C. Beverstock, S. Schnittger, M. Katsuki, V.G. Matveeva, T. Shinohara, J. García-Heras, S.C. Bock, T.B. Shows, K. Klinger, A.P. Jackson, H. van Kamp, Franki Speleman, D.S. Gallagher, P.M. Kluin, A. Kuwano, T. Kajii, H.A. Taylor, B. Redeker, P. Van Oostveldt, T. Pihlajaniemi, JG Leroy, G.N. Hendy, Marcel M.A.M. Mannens, I.W. Craig, P. Avner, T. Abe, B.H. Robinson, V.L. Singer, P. Parham, E.K. Bijlsma, G. Levan, S. Kohno, S.J. Sadler, and V.V.N.G. Rao

Subjects
Genetics, Library science, Table of contents, Biology, Title page, Molecular Biology, Genetics (clinical)
Published
1991
Full Text
View/download PDF

4. Contents, Vol. 56, 1991

Author

G. Levan, S.P. Craig, I.W. Craig, I.V. Nikitina, N.J. Nowak, T. Pihlajaniemi, C.A. Kozak, M.C. Simmler, H.A. Taylor, C. Collet, G.N. Hendy, C.-L. Hsieh, P. Van Oostveldt, R.G. Taylor, J.A. Miller, M.C. Darmon, A.C.B. Peters, J.W. Wessels, E. Solomon, M.A. Abruzzo, T. Abe, S.M. Zakian, M. Kimura, Y. Nakai, D. Sheer, B.M. Cattanach, Rosalyn Slater, Franki Speleman, P.M. Kluin, A. Kuwano, M. Westerman, S. Kohno, S.J. Sadler, N.S.-F. Ma, D.S. Gallagher, V.E. Powers, T.B. Shows, J. George, M. Van der Ploeg, K. Klinger, G.M. Greig, G. Otulakowski, M.C. Phelan, V.L. Singer, J. Szpirer, A.K. Raap, A. Geurts van Kessel, W.E. Fibbe, V.V.N.G. Rao, M. Vercruyssen, E.P. Evans, E.P.J. Arnoldus, E.J. Dreef, L.-C. Tsui, P. Parham, I. Hansmann, S. Parikh, L. Shi, L.T. Williams, R.E. Kibbelaar, J. Hayakawa, T. Kajii, M. Rivière, T. Shinohara, D.S. Gerhard, E.K. Bijlsma, M.G. Byers, A.P. Jackson, S.W. Scherer, S. Boularand, F. Yang, J. Mallet, J.A. Escobedo, Andries Westerveld, H.F. Willard, Roger E. Stevenson, R.R. Mclnnes, P. Stanislovitis, H. van Kamp, D.W. Threadgill, T. Koizumi, T.B. Nesterova, J.E. Womack, N.B. Rubtsov, T.A. Jones, T.J.M. Hulsebos, M. Danciger, S. Kubota, M. Katsuki, D.H. Ledbetter, S. Navankasattusas, C. Szpirer, V.G. Matveeva, S.I. Radjabli, L. Pajunen, R.H. Brakenhoff, J. García-Heras, G.C. Beverstock, S.C. Bock, Charles E. Schwartz, L. Dandolo, S. Schnittger, I.A. Noordermeer, C. Hanson, B.H. Robinson, A. Kumamoto, D.B. Farber, C. Rasberry, B. Redeker, K.I. Kivirikko, G.J. den Ottolander, H. Nakai, JG Leroy, Marcel M.A.M. Mannens, P. Avner, U. Francke, J. Spencer, R.G. Lafreniere, and A. Goddard

Subjects
Botany, Genetics, Zoology, Biology, Molecular Biology, Genetics (clinical)
Published
1991
Full Text
View/download PDF

5. Subject Index Vol. 56, 1991

Author

L. Dandolo, D.S. Gallagher, P.M. Kluin, A. Kuwano, B.H. Robinson, G. Otulakowski, S.P. Craig, N.J. Nowak, G. Levan, M. Van der Ploeg, M.A. Abruzzo, A.C.B. Peters, P. Stanislovitis, Charles E. Schwartz, M.C. Simmler, L.-C. Tsui, D.W. Threadgill, C.A. Kozak, D. Sheer, A. Kumamoto, M.C. Darmon, A.K. Raap, I.V. Nikitina, S.M. Zakian, S. Kubota, M. Kimura, D.H. Ledbetter, A. Goddard, S. Kohno, S.J. Sadler, T. Kajii, D.S. Gerhard, D.B. Farber, S.W. Scherer, JG Leroy, R.R. Mclnnes, Marcel M.A.M. Mannens, C. Rasberry, C. Hanson, M. Vercruyssen, T. Koizumi, J. Mallet, Rosalyn Slater, P. Avner, U. Francke, M. Rivière, N.B. Rubtsov, V.L. Singer, K.I. Kivirikko, E.K. Bijlsma, P. Parham, T.B. Nesterova, J.E. Womack, J. Spencer, M.C. Phelan, B. Redeker, S. Navankasattusas, G.N. Hendy, V.V.N.G. Rao, R.G. Lafreniere, J.W. Wessels, Y. Nakai, C. Szpirer, B.M. Cattanach, R.G. Taylor, Andries Westerveld, M. Westerman, I. Hansmann, J. George, E. Solomon, G.J. den Ottolander, S. Boularand, V.E. Powers, Roger E. Stevenson, H. Nakai, T. Abe, G.M. Greig, M. Danciger, N.S.-F. Ma, L. Pajunen, J. Hayakawa, G.C. Beverstock, C.-L. Hsieh, J.A. Miller, S. Schnittger, H.F. Willard, S.I. Radjabli, R.H. Brakenhoff, A. Geurts van Kessel, E.J. Dreef, S. Parikh, L. Shi, A.P. Jackson, H. van Kamp, T.B. Shows, K. Klinger, I.A. Noordermeer, C. Collet, M. Katsuki, V.G. Matveeva, J. García-Heras, S.C. Bock, T. Pihlajaniemi, R.E. Kibbelaar, M.G. Byers, F. Yang, H.A. Taylor, P. Van Oostveldt, J. Szpirer, E.P.J. Arnoldus, I.W. Craig, W.E. Fibbe, E.P. Evans, Franki Speleman, T. Shinohara, L.T. Williams, J.A. Escobedo, T.A. Jones, and T.J.M. Hulsebos

Subjects
Index (economics), Statistics, Genetics, Subject (documents), Biology, Molecular Biology, Genetics (clinical)
Published
1991
Full Text
View/download PDF

6. Adult T-cell leukemia: a report on two white patients

Author

R. L. Verwilghen, G. Tricot, C.J.L.M. Meyer, A. Broeckaert-Van Orshoven, J. Jansen, G.J. Den Ottolander, and C. de Wolf-Peeters

Subjects
Adult, Male, Cancer Research, Pathology, medicine.medical_specialty, Rosette Formation, Skin Neoplasms, T-Lymphocytes, T-cell leukemia, Lymph node biopsy, Biology, DNA Nucleotidylexotransferase, hemic and lymphatic diseases, Acute lymphocytic leukemia, medicine, Humans, Neoplasm Metastasis, Lymph node, Leukemia, medicine.diagnostic_test, Histocytochemistry, Histocompatibility Antigens Class II, Antibodies, Monoclonal, Bone Marrow Examination, Hematology, Middle Aged, medicine.disease, Bone marrow examination, Microscopy, Electron, medicine.anatomical_structure, Oncology, Immunology, Bone marrow, Lymph, Lymph Nodes
Abstract

Two white European males are reported with adult T-cell leukemia (ATL), a disease first described in Japan, but recently also in the U.K. and U.S.A. Both patients presented with lymphadenopathy, but without a mediastinal mass. In addition, one patient had skin infiltrates and the other had hepatosplenomegaly. Morphologic and ultrastructural examination of the blasts in bone marrow and lymph node biopsy revealed a predominance of polymorphic lymphoid cells with pronounced nuclear irregularities and a semi-mature chromatine pattern. Histopathology of the lymph nodes showed a diffuse infiltration with medium-sized lymphoblasts with irregular nuclei. The blasts in the bone marrow formed E rosettes with sheep erythrocytes, lacked terminal deoxynucleotidyl transferase (Tdt) activity but expressed the Ia-like antigen; although the majority of the cells reacted with a polyclonal anti-T-cell serum, they were negative for OKT3. In one patient a helper/inducer phenotype (OKT4+) was found in the lymphoblasts of bone marrow and lymph node, while in the other only in the lymph node. The difference between bone marrow and lymph node phenotype is discussed. To our knowledge, these are the first two European patients reported with ATL, a disease clearly different from convoluted T-cell acute lymphocytic leukemia.

Published
1983

7. Detection of trisomy 8 in hematological disorders by in situ hybridization

Author

J. W. Wessels, E.J. Dreef, Ph. M. Kluin, A. K. Raap, R E Kibbelaar, Willem E. Fibbe, Geoffrey C. Beverstock, H. van Kamp, and G.J. den Ottolander

Subjects
Aneuploidy, Chromosomal translocation, Chromosome Disorders, Trisomy, Biology, Trisomy 8, hemic and lymphatic diseases, Genetics, medicine, Humans, Molecular Biology, Genetics (clinical), Repetitive Sequences, Nucleic Acid, Chromosome Aberrations, Hybridization probe, Chromosome, Nucleic Acid Hybridization, Karyotype, medicine.disease, Molecular biology, Chromosome Banding, Leukemia, Microscopy, Fluorescence, Leukemia, Myeloid, DNA Probes, Chromosomes, Human, Pair 8
Abstract

An alphoid repetitive DNA (D8Z2) probe specific for the pericentromeric region of chromosome 8 was used to detect extra copies of chromosome 8 in bone marrow cells obtained from 10 patients with hematological disorders and five controls. Numerical aberrations of chromosome 8 were established by conventional banding techniques. Trisomy 8 was found in four patients with myelodysplastic syndrome (MDS) and three with acute myeloid leukemia (AML). Three additional patients with MDS exhibited an extra chromosome 8 in only one metaphase. In five of the seven trisomy cases, the presence of the trisomy 8 clone was confirmed by in situ hybridization (ISH). In one case of AML with trisomy 8, detected by GTG-banding, no significant numbers of cells containing three spots were found using the alphoid repetitive probe; however, hybridization with a chromosome 8-specific library revealed that the alleged extra chromosome 8 was a translocation chromosome containing only the long arm of chromosome 8. Due to a lack of material, it was not possible to achieve optimal ISH results on the trisomy 8 bone marrow cells of patient 7. In the three MDS patients with a single trisomy 8 metaphase, a slight, albeit significant, increase of trisomy 8 interphase cells was found with ISH. We conclude that this probe is useful for cytogenetic studies. Moreover, ISH, in general, is a powerful tool for precise classification of chromosomal aberrations and can also contribute significantly to the clinical evaluation of patients with hematological disorders.

Catalog

Books, media, physical & digital resources
See catalog results