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2. Contents, vol. 50, Supplement 2, 1986

Author

M. Noto, S. Shimura, W. Shaqadan, M. Pasargiklian, G. Ciappi, P. Guerzoni, J.G. Widdicombe, A.W. Bodas, W. Fasano, S.M. Distefano, Helen Ramsdale, J.P. Delwiche, R. Carnimeo, A. Mistretta, Giorgio Segre, Virginia De Rose, C. Sena, Esko Huhti, Peter Sterk, C. Tantucci, Jorge Torres, N. Alessi, Patrizia Mangiarotti, G. Peralta, N. Del Bono, P. Carnicelli, L. Cervone, M.P. Foschino Barbaro, S. Bianco, P. Gaicomelli, Ulf Pipkorn, C. Vancheri, H. Inoue, V. Massei, Enrico Maggi, M. Robuschi, E. Angelici, P. Magnini, R. Barnabè, P. Hedqvist, A. Bisetti, G. Funaro, F. Cresci, Giuliana Gialdroni Grassi, J. Garcia Barbal, S. Valente, Y. Shimizu, G.E. Marlin, B. Jenner, W. Hida, A. Pesci, E. Fornai, F. Peccini, J. Prignot, N. Pulerà, O. Taguchi, Robert M. Naclerio, L. Marazzini, Y. Okazaki, R. Pinto, Peter J. Barnes, M. Scarpitta, Robert P. Schleimer, F.L. Dente, C. Cavalieri, G. Fontana, G. Bertorelli, W.T. Ulmer, P. Noceti, S. Sensi, J. Diaz, J.A. Nadel, J. Lulling, R. Pulejo, C. Serra, L. Toscano, G. Culla, V. Bellia, G. De Cataldis, Sven-Erik Dahlén, J. Crane, F. Madsen, S. Carlone, N. Crimi, L. Frølund, A.L. De Masi, M. Cervone, G. Virgili, A. Vaghi, Myrna Dolovich, H. Sasaki, P. Panuccio, K.B.P. Leung, A. Grieco, Kari Sahlström, M. Mugnai, F. Bergero, F. Bariffi, B. Cacopardo, T. Takishima, Pietro Zanon, Frederick E. Hargreave, F. Palermo, S. Mirabelli, G.H. Russo, H. Nogami, A. Santolicandro, M. Rossi, P.A. Frith, Gian Franco Del Prete, L. Del Bono, T. Sasaki, D. Pérez, P.E.P. Dubois, C. Giuntini, E Adelroth, L. Del Torre, Stephen C. Lazarus, M. Lelli, C.A. Bellía, S. De Luca, K.C. Flint, A. Sanduzzi, J. Brostoff, Juan Antonio Mazzei, Mario Ricci, A. Petraglia, L. Romano, N.McI. Johnson, Anna Fietta, R.C. Calvanese, C.M. Sanguinetti, E.R. McFadden, P. Palange, Stephen P. Peters, D. Ansalone, Elisabeth Granström, J.L. Calpe, U.G. Svendsen, B. Mastropasqua, Warren M. Gold, M. Bozzoni, B. Bruni, P. Simone, F. Patalano, D.C. Flenley, Risto Härkönen, P. Minette, B. Weeke, G. Garofalo, E. Longhini, A. Baronti, G.N. Colasurdo, V. Picca, Lawrence M. Lichtenstein, Kari Alanko, G. Bonsignore, A. Mori, M. Moretti, Sergio Romagnani, R. Aquilina, C. Ciccarello, L. Cecere, Paul M. O'Byrne, C.F. Marchioni, O. Resta, D. McIntosh, F.L. Pearce, G. Luciani, A. Giacopelli, P. Vergara, T. Todisco, E. Servera, M. Newhouse, J. Atkinson, P. Serra, S. Gasparini, G. De Matthaeis, John M. Shneerson, B.N. Hudspith, Maria Kumlin, M. Pirrelli, Donald W. MacGlashan, S. Macaluso, N. Carnimeo, F. De Benedetto, E. Marangio, G. Migliara, M.E. D’Amore, G.M Corbo, M. Marchioni, Carlo Grassi, J. Marín, Anneli Poukkula, and V. Grassi

Subjects
Pulmonary and Respiratory Medicine, Traditional medicine, business.industry, Medicine, business
Published
1986
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3. Evaluation of Bronchial Responsiveness by Pharmacological Challenges in Asthma

Author

Antonio Foresi, A. Chetta, G. Garavaldi, A. Cuomo, Dario Olivieri, and G.M. Corbo

Subjects
Pulmonary and Respiratory Medicine, Inhalation, business.industry, Propranolol, respiratory system, medicine.disease, respiratory tract diseases, chemistry.chemical_compound, chemistry, Bronchial hyperresponsiveness, Anesthesia, Immunology, medicine, Reflex, Methacholine, Bronchoconstriction, medicine.symptom, business, Histamine, medicine.drug, Asthma
Abstract

Bronchial challenges with bronchoconstrictive drugs have supplied important information on some relevant pathophysiological aspects of bronchial asthma, i.e. nonspecific bronchial hyperresponsiveness. Until now histamine and methacholine have been the most widely used inhalation tests. Recently, propranolol, given by inhalation, has been proposed and evaluated for possible application as a bronchial provocation challenge both in clinical and experimental setting. In asthmatic subjects with bronchial hyperresponsiveness to histamine and methacholine, inhaled propranolol induces a dose-related bronchoconstriction. In a group of 25 asthmatic patients, the mean value of provocative doses, in μmoles of propranolol that causes a 20% drop in FEV1 (PD20FEV1), is thirteen times greater than that of methacholine. In the same study, there is no correlation between the bronchial responses to the two drugs. Moreover, none of 9 normal subjects of the control group responds to inhaled propranolol. The mechanisms of propranolol-induced bronchoconstriction are poorly understood. A cholinergic reflex is probably involved, but it is likely that propranolol has some different and rather peculiar pathways. Bronchial response to inhaled propranolol is a reliable, reproducible, safe, and well-tolerated method. Bronchoconstriction induced by propranolol appears to be a very promising technique in the investigation of the mechanisms of nonspecific bronchial hyperresponsiveness.

Published
1988
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4. Contents, Vol. 54, Supplement 1, 1988

Author

R. Minisini, O. Sacco, M. Spatafora, Patricia S. Mikes, S. Poggi, A. Merendino, P. Boschetto, G.M. Corbo, A. Misiretta, S. Crescioli, A. Miadonna, P. Manganelli, A. Sala, S. Bellofiore, C.E. Mapp, G. Garavaldi, R. Polosa, M. Melis, R. Ferracini, A. Pesci, A. Cuomo, G. Chiappara, M. Froldi, L. Degli Innocenti, L. Bianco, E. Leggieri, F. Barilli, M. Anghinolfi, P. Rottoli, G.V. Marchetti, G. Bonsignore, V. Cicchetti, L. Spiga, P. Maestrelli, F. Palermo, M. Gjomarkaj, Michele R. De Musis, G.F. Consigli, F. Strinati, E. Zocca, A. Collodoro, M. Patelli, G. Bertorelli, V. Cantoni, A. Foresi, P.A. Mori, C. Ravazzoni, Lydia L. Polomski, L.M. Fabbri, Maria Robuschi, M.G. Perari, Herbert Y. Reynolds, S. Scarpa, D. Olivieri, C. Vancheri, R. Oliveri, G. U. Di Maria, G. Carriero, A. Chetta, Gianpietro Semenzato, Theodore A. Marcy, L. Rottoli, N. De Marzo, E. Marangio, S. Bianco, C. Zanussi, F. Sabino, G.C. Folco, A. Tedeschi, A. Mistretta, T. Bertanti, N. Crimi, G.A. Rossi, F. Vassallo, P.P. Dall’Aglio, Bernard L. Gee, J.G. Martin, P. Ghirardi, E. Brianti, B. Palermo, C. Brasca, V. Bellia, William Merrill, and V. Poletti

Subjects
Pulmonary and Respiratory Medicine, Traditional medicine, business.industry, Medicine, business
Published
1988
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5. Contents, Vol. 51, 1987

Author

A. Agustí-Vidal, Marshal Stark, Constantinos S. Papadimitriou, Martin L. Ogletree, Antony James Bayer, M. Clay, R.G. Taylor, Kenneth L. Brigham, Stavros H. Constantopoulos, Mitsuru Munakata, A. Foresi, S. Valente, Seiichiro Fujimoto, H. Koral, A. Hallak, A. Marín, J.-D. Aubert, Carlo Ludovico Maini, S.W. Clarke, Alessandro Giordano, M.G. Bonetti, Yoshikazu Kawakami, Mathildi P. Papathanasiou, Shosaku Abe, C. Agustí, Anneli Poukkula, Rodolfo Muzzolon, M. Burke, James R. Snapper, V. Beer, R.A. Francis, Nicolas A. Pavlidis, John Pathy, G.M. Corbo, Vasiliki D. Malamou-Mitsi, Salvatore Paoletti, R. Arriols, E. Huhti, J.M. Montserrat, Anna Gajewska, Leonello Fuso, John A. Goudevenos, A. Xaubet, M.E. Kitler, G. Polidori, Riccardo Pistelli, Ch. Almog, Mark Stephens, P. Leuenberger, G. Ciappi, M. Hakala, Raffaele Antonelli Incalzi, and M.T. Lopez-Vidriero

Subjects
Pulmonary and Respiratory Medicine, Traditional medicine, business.industry, Medicine, business
Published
1987
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6. Provocative dose and dose-response curve to inhaled propranolol in asthmatic patients with bronchial hyperresponsiveness to methacholine

Author

Antonio Foresi, Dario Olivieri, A. Cuomo, G.M. Corbo, and Alfredo Chetta

Subjects
Pulmonary and Respiratory Medicine, Male, medicine.medical_specialty, Propranolol, Critical Care and Intensive Care Medicine, Gastroenterology, Bronchial Provocation Tests, Internal medicine, Forced Expiratory Volume, medicine, Humans, Methacholine Compounds, Methacholine Chloride, Asthma, Inhalation, Dose-Response Relationship, Drug, business.industry, medicine.disease, Dose–response relationship, Bronchial hyperresponsiveness, Anesthesia, Bronchoconstriction, Methacholine, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, business, medicine.drug
Abstract

This study was carried out to compare bronchial responses to inhaled propranolol (P) and methacholine (M) in a group of asthmatic subjects with mild to moderate bronchial hyperresponsiveness to M; to determine the short term reproducibility of bronchial response to propranolol; and to examine the shape of dose-response curve to P relative to that of M. Doses of M and P were given in mumoles and bronchial responses to both agents were expressed as the provocative dose that induced a 20 percent fall in FEV1 (PD20 FEV1). In 16 asthmatic patients, there was no correlation between the PD20 of the two agents. Mean PD20 M (+/- SD in log scale) was approximately nine times lower than mean PD20 P (0.64 +/- 0.96 and 5.80 +/- 1.65, respectively). This difference was statistically significant (t = 4.58, p less than 0.001). In six asthmatic patients, the reproducibility of PD20 P was similar to that of M (intraclass correlation coefficient 0.969 and 0.957, respectively). The shape of the dose-response curves to P was different from that of M in five of nine asthmatic patients when all experimental points were analyzed by double-reciprocal plot. We noticed that even small doses of inhaled P may cause a severe bronchoconstriction. Therefore, special caution should be taken to increase P doses very gradually, when studying the dose-response curve. We demonstrated that P inhalation induced a measurable bronchoconstriction in subjects with mild to moderate hyperresponsiveness and it was reproducible. However, the bronchial sensitivity to P was lower than to M. Our findings suggest that P and M have different mechanisms of action.

Published
1987

7. Subject Index, Vol. 51, 1987

Author

A. Foresi, R.G. Taylor, Mitsuru Munakata, Seiichiro Fujimoto, Alessandro Giordano, S. Valente, J.M. Montserrat, R.A. Francis, Leonello Fuso, Carlo Ludovico Maini, John A. Goudevenos, Shosaku Abe, C. Agustí, Raffaele Antonelli Incalzi, Nicolas A. Pavlidis, M.T. Lopez-Vidriero, A. Xaubet, M.E. Kitler, G. Polidori, Kenneth L. Brigham, Rodolfo Muzzolon, James R. Snapper, Vasiliki D. Malamou-Mitsi, M.G. Bonetti, E. Huhti, Mathildi P. Papathanasiou, G.M. Corbo, M. Hakala, Salvatore Paoletti, R. Arriols, H. Koral, John Pathy, A. Marín, G. Ciappi, Antony James Bayer, Martin L. Ogletree, A. Agustí-Vidal, Mark Stephens, Anneli Poukkula, Anna Gajewska, Yoshikazu Kawakami, M. Burke, V. Beer, P. Leuenberger, A. Hallak, Marshal Stark, Constantinos S. Papadimitriou, M. Clay, S.W. Clarke, Stavros H. Constantopoulos, J.-D. Aubert, Riccardo Pistelli, and Ch. Almog

Subjects
Pulmonary and Respiratory Medicine, Index (economics), business.industry, Statistics, Medicine, Subject (documents), business
Published
1987
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8. Subject Index, Vol. 54, Supplement 1, 1988

Author

P. Manganelli, R. Polosa, S. Bellofiore, B. Palermo, L. Degli Innocenti, William Merrill, M. Froldi, C. Brasca, V. Bellia, P. Rottoli, G.V. Marchetti, L. Spiga, M. Melis, P.A. Mori, J.G. Martin, Lydia L. Polomski, N. De Marzo, E. Marangio, F. Strinati, N. Crimi, F. Palermo, L. Rottoli, C. Ravazzoni, Michele R. De Musis, Maria Robuschi, R. Ferracini, G.A. Rossi, S. Scarpa, E. Zocca, L. Bianco, D. Olivieri, F. Vassallo, G. Bertorelli, G. Garavaldi, G.F. Consigli, A. Merendino, F. Barilli, M.G. Perari, Gianpietro Semenzato, C. Vancheri, V. Cantoni, P. Ghirardi, A. Cuomo, Patricia S. Mikes, R. Minisini, O. Sacco, E. Brianti, Herbert Y. Reynolds, A. Foresi, A. Misiretta, S. Crescioli, A. Miadonna, S. Poggi, G. Bonsignore, Theodore A. Marcy, P. Boschetto, F. Sabino, A. Tedeschi, L.M. Fabbri, C. Zanussi, G. U. Di Maria, P. Maestrelli, M. Gjomarkaj, M. Patelli, A. Chetta, C.E. Mapp, M. Spatafora, G. Carriero, G.M. Corbo, A. Pesci, M. Anghinolfi, R. Oliveri, V. Cicchetti, G. Chiappara, Bernard L. Gee, T. Bertanti, A. Sala, E. Leggieri, A. Collodoro, V. Poletti, P.P. Dall’Aglio, G.C. Folco, A. Mistretta, and S. Bianco

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, Index (economics), business.industry, Physical therapy, medicine, Subject (documents), business
Published
1988
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