Search

Objective. To study the expression level of long non-coding RNAs ROR and MALAT1 in tissue samples of uterine fibroids. Patients and methods. Samples of myomatous nodes and tissues of normal myometrium in 28 women of reproductive age were examined. The analysis of the expression of long non-coding RNAs was carried out using a real-time reverse-transcription polymerase chain reaction (RT-PCR) with specific primers. Results. There was a significant decrease in the expression level of long non-coding RNA ROR and an increase in the MALAT1 expression in tissue samples of uterine fibroids relative to the control group. Conclusion. The results obtained demonstrate a possible role of long non-coding RNAs in the development of uterine fibroids and correlate with the data which we obtained for patients with endometriosis. Detecting the expression level of long non-coding RNAs can improve the existing methods for diagnosing this disease. However, further research is required to determine the clinical significance of MALAT1 and ROR, and the molecular mechanisms underlying the action of these RNAs in uterine fibroid cells. Key words: long non-coding RNAs, uterine fibroids, myomectomy, lncROR, MALAT1

Catamenial pneumothorax is a rare cause of spontaneous pneumothorax in women of reproductive age and one of the thoracic endometriosis manifestations. Researchers have shown an increased interest in catamenial pneumothorax but a clear treatment strategy for this pathology has not been developed yet. The thoracoscopic revision of the pleural cavity, as well as the identification and subsequent histological verification of ectopic endometriosis foci, play a crucial role in patient management. This case report describes the successful treat-ment of a patient with recurrent catamenial tension pneumothorax and following multidisciplinary analysis. Keywords: catamenial pneumothorax, thoracic endometriosis, histological examination