1. One-carbon cycle alterations induced by Dyrk1a dosage
- Author
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Sacha Salameh, Marjorie Renon, Nathalie Janel, M.L. Arbonés, Jean-Maurice Delabar, Jean-Louis Paul, Jamileh Movassat, Alizée Latour, Christophe Noll, Jérôme Lejeune Foundation, and L'Association Gaspard Félix (France)
- Subjects
medicine.medical_specialty ,Hyperhomocysteinemia ,GK, Goto-Kakizaki ,Homocysteine ,DYRK1A ,DYRK, dual-specificity tyrosine-(Y)-phosphorylation regulated kinase ,Short Communication ,Transsulfuration ,PLP, pyridoxal phosphate ,Biology ,NQO1, NAD(P)H:quinone oxidoreductase ,hcy, homocysteine ,chemistry.chemical_compound ,Endocrinology ,Internal medicine ,Genetics ,medicine ,SAHH, SAH hydrolase ,PTZ, pentylenetetrazole ,Molecular Biology ,lcsh:QH301-705.5 ,Cystathionine beta synthase ,lcsh:R5-920 ,Methionine ,GABA, gamma-amino-butyric-acid ,SAH, S-adenosylhomocysteine ,medicine.disease ,DS, Down syndrome ,CBS, cystathionine beta synthase ,chemistry ,Biochemistry ,Liver ,lcsh:Biology (General) ,biology.protein ,Dyrk1a ,Murine model ,EGCG, epigallocatechin-gallate ,Signal transduction ,lcsh:Medicine (General) ,Cysteine - Abstract
© 2014 The Authors. Published by Elsevier Inc. Hyperhomocysteinemia due to cystathionine beta synthase deficiency confers diverse clinical manifestations. It is characterized by elevated plasma homocysteine levels, a common amino acid metabolized by remethylation to methionine or transsulfuration to cysteine.We recently found a relationship between hepaticDyrk1A protein expression, a serine/threonine kinase involved in signal transduction in biological processes, hepatic S-adenosylhomocysteine activity, and plasma homocysteine levels.We aimed to study whether there is also a relationship between Dyrk1a and cystathionine beta synthase activity. We used different murine models carrying altered gene coy numbers for Dyrk1a, and found a decreased cystathionine beta synthase activity in the liver of mice under-expressing Dyrk1a, and an increased in liver of mice over-expressing Dyrk1a. For each model, a positive correlation was found between cystathionine beta synthase activity and Dyrk1a protein expression in the liver of mice, which was confirmed in a non-modified genetic context. The positive correlation found between liver Dyrk1a protein expression and CBS activity in modified and non-modified genetic context strengthens the role of this kinase in one carbon metabolism., This work was supported by the Fondation Jérôme Lejeune (30CA1140087) and the Association Gaspard Félix (L'AGAFE) (30S1B07)
- Published
- 2014