Search

Your search keyword '"GAYAT, Etienne -- 0000-0002-3334-3849"' showing total 6 results
Start Over Author "GAYAT, Etienne -- 0000-0002-3334-3849"
6 results on '"GAYAT, Etienne -- 0000-0002-3334-3849"'

1. Effect of precipitating factors of acute heart failure on readmission and long‐term mortality

Author

Elodie Feliot, Mehmet Yilmaz, Patrick Plaisance, Alexandre Mebazaa, Malha Sadoune, Antônio Lúcio Teixeira, Semir Nouira, Heli Tolppanen, Said Laribi, Etienne Gayat, Mattia Arrigo, [Arrigo, Mattia -- Tolppanen, Heli -- Sadoune, Malha -- Feliot, Elodie -- Teixeira, Antonio -- Laribi, Said -- Gayat, Etienne -- Mebazaa, Alexandre] INSERM, UMR S 942, Paris, France -- [Teixeira, Antonio -- Laribi, Said -- Plaisance, Patrick -- Gayat, Etienne -- Mebazaa, Alexandre] Univ Paris Diderot, PRES Sorbonne Paris Cite, Paris, France -- [Teixeira, Antonio] St Louis Lariboisiere Univ Hosp, AP HP, Dept Geriatr, F-75475 Paris 10, France -- [Laribi, Said -- Plaisance, Patrick] St Louis Lariboisiere Univ Hosp, AP HP, Dept Emergency Med, F-75475 Paris 10, France -- [Nouira, Semir] Fattouma Bourguiba Univ Hosp, Emergency Dept, Monastir, Tunisia -- [Yilmaz, Mehmet Birhan] Cumhuriyet Univ Hosp, Sivas, Turkey -- [Gayat, Etienne -- Mebazaa, Alexandre] St Louis Lariboisiere Univ Hosp, AP HP, Dept Anesthesiol & Crit Care Med, F-75475 Paris 10, France, YILMAZ, Mehmet Birhan -- 0000-0002-8169-8628, YILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628, Arrigo, Mattia -- 0000-0003-4028-2869, GAYAT, Etienne -- 0000-0002-3334-3849, and Mebazaa, Alexandre -- 0000-0001-8715-7753

Subjects
medicine.medical_specialty, Acute coronary syndrome, Population, Pulmonary disease, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Original Research Articles, Internal medicine, medicine, Original Research Article, 030212 general & internal medicine, Mortality, Intensive care medicine, education, education.field_of_study, business.industry, Acute heart failure, Atrial fibrillation, medicine.disease, Confidence interval, Heart failure, Cohort, Precipitating factor, Long term mortality, Cardiology and Cardiovascular Medicine, business, Readmission
Abstract

WOS: 000374984300007, PubMed ID: 27812386, AimsAcute heart failure (AHF) is one of the leading causes of unscheduled hospitalization and is associated with frequent readmissions and substantial mortality. Precipitating factors of AHF influence short-term mortality, but their effect on outcome after hospital discharge is unknown. The present study assessed the effect of precipitating factors on readmission and long-term survival in the overall population and in patients aged 75years or younger. Methods and resultsPatients admitted with AHF (n=755) included in the multicentre cohort Biomarcoeurs' were included in the study. Precipitating factors of AHF were classified in four main groups: acute coronary syndrome, atrial fibrillation, acute pulmonary disease and other causes. Hospital readmission during 90days after discharge and survival at 1year were analysed. Precipitating factors influenced readmissions and survival. Acute pulmonary disease was associated with fewer readmissions (HR 0.61, 95% confidence interval (CI) 0.37-0.99, P=0.049), especially in patients aged 75years or younger (HR 0.20, 95% CI 0.06-0.63, P=0.006), whereas atrial fibrillation (HR 2.23, 95% CI 1.29-3.85, P=0.004) and acute coronary syndrome (HR 2.23, 95% CI 1.02-4.86, P=0.044) were associated with more readmissions. Patients with acute pulmonary disease at admission showed higher mortality (HR 1.59, 95% CI 1.04-2.43, P=0.034), especially in subjects aged 75years or younger (HR 2.52, 95% CI 1.17-5.41, P=0.018). ConclusionsPrecipitating factors of AHF substantially influenced outcome after hospitalization. In particular, patients with AHF precipitated by acute pulmonary disease showed fewer readmissions and higher 1year mortality, especially in patients aged 75years or younger.

Published
2016
Full Text
View/download PDF

2. Emergency management of severe hyperkalemia: Guideline for best practice and opportunities for the future

Author

Rossignol, Patrick, Legrand, Matthieu, Kosiborod, Mikhail, Hollenberg, Steven M., Peacock, W. Frank, Emmett, Michael, Epstein, Murray, Kovesdy, Csaba P., Yilmaz, Mehmet Birhan, Stough, Wendy Gattis, Gayat, Etienne, Pitt, Bertram, Zannad, Faiez, Mebazaa, Alexandre, [Rossignol, Patrick -- Zannad, Faiez] Univ Lorraine, CHU Nancy, Assoc Lorraine Traitement Insuffisance Renale, INSERM,F CRIN INI CRCT,Ctr Invest Clin 1433, Nancy, France -- [Rossignol, Patrick -- Zannad, Faiez] Univ Lorraine, CHU Nancy, Assoc Lorraine Traitement Insuffisance Renale, INSERM,F CRIN INI CRCT,U1116, Nancy, France -- [Legrand, Matthieu -- Mebazaa, Alexandre] Univ Paris 07, St Louis Hosp, INSERM, Dept Anesthesiol,Crit Care & Burn Unit,UMR S942, Paris, France -- [Legrand, Matthieu -- Mebazaa, Alexandre] F CRIN INI CRCT Nancy, Paris, France -- [Legrand, Matthieu -- Mebazaa, Alexandre] GREAT Network, Paris, France -- [Kosiborod, Mikhail] St Lukes Mid Amer Heart Inst, Kansas City, MO USA -- [Kosiborod, Mikhail] Univ Missouri, Kansas City, MO 64110 USA -- [Hollenberg, Steven M.] Cooper Univ Hosp, Div Cardiovasc Dis, Camden, NJ USA -- [Hollenberg, Steven M.] Cooper Univ Hosp, Div Crit Care Med, Camden, NJ USA -- [Peacock, W. Frank] Ben Taub Hosp, Baylor Coll Med, Houston, TX USA -- [Emmett, Michael] Baylor Univ, Med Ctr, Baylor Scott & White Hlth Care, Dallas, TX USA -- [Epstein, Murray] Univ Miami, Miller Sch Med, Div Nephrol & Hypertens, Miami, FL 33136 USA -- [Kovesdy, Csaba P.] Univ Tennessee, Hlth Sci Ctr, Div Nephrol, Memphis, TN USA -- [Yilmaz, Mehmet Birhan] Cumhuriyet Univ, Dept Cardiol, Fac Med, Sivas, Turkey -- [Stough, Wendy Gattis] Campbell Univ, Coll Pharm & Hlth Sci, Dept Clin Res, Buies Creek, NC 27506 USA -- [Stough, Wendy Gattis] Campbell Univ, Coll Pharm & Hlth Sci, Dept Pharm Practice, Buies Creek, NC 27506 USA -- [Gayat, Etienne] Univ Paris Diderot, Hop Univ St Louis Lariboisiere, AP HP, Dept Anesthesie Reanimat SMUR,INSERM,UMR 942, Paris, France -- [Pitt, Bertram] Univ Michigan, Sch Med, Ann Arbor, MI USA, YILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628, YILMAZ, Mehmet Birhan -- 0000-0002-8169-8628, Kovesdy, Csaba -- 0000-0002-8204-911X, GAYAT, Etienne -- 0000-0002-3334-3849, and Mebazaa, Alexandre -- 0000-0001-8715-7753

Subjects
Diabetes mellitus, Arrhythinias, Hyperkalemia, Renal insufficiency, Emergencies, Cardiac
Abstract

WOS: 000389086800058, PubMed ID: 27693804, Hyperkalemia is a common electrolyte disorder, especially in chronic kidney disease, diabetes mellitus, or heart failure. Hyperkalemia can lead to potentially fatal cardiac dysrhythmias, and it is associated with increased mortality. Determining whether emergency therapy is warranted is largely based on subjective clinical judgment. The Investigator Network Initiative Cardiovascular and Renal Clinical Trialists (INI-CRCT) aimed to evaluate the current knowledge pertaining to the emergency treatment of hyperkalemia. The INI-CRCT developed a treatment algorithm reflecting expert opinion of best practices in the context of current evidence, identified gaps in knowledge, and set priorities for future research. We searched PubMed (to August 4, 2015) for consensus guidelines, reviews, randomized clinical trials, and observational studies, limited to English language but not by publication date. Treatment approaches are based on small studies, anecdotal experience, and traditional practice patterns. The safety and real world effectiveness of standard therapies remain unproven. Prospective research is needed and should include studies to better characterize the population, define the serum potassium thresholds where life threatening arrhythmias are imminent, assess the potassium and electrocardiogram response to standard interventions. Randomized, controlled trials are needed to test the safety and efficacy of new potassium binders for the emergency treatment of severe hyperkalemia in hemodynamically stable patients. Existing emergency treatments for severe hyperkalemia are not supported by a compelling body of evidence, and they are used inconsistently across institutions, with potentially significant associated side effects. Further research is needed to fill knowledge gaps, and definitive clinical trials are needed to better define optimal management strategies, and ultimately to improve outcomes in these patients. (C) 2016 Elsevier Ltd. All rights reserved., ZS Pharma, This work was generated from discussions during a workshop held in New York in May 2015. It was set-up jointly by the FCRIN (French Clinical Research Infrastructure Network), INI-CRCT, Nancy, France, and CVCT (Cardiovascular Clinical Trialists), under the framework of the Clinical Investigation Center (CIC) Inserm, CHU, and University of Lorraine, France, and endorsed by the GREAT acute conditions care international network. The meeting was funded by an unrestricted educational grant from ZS Pharma. ZS Pharma had no involvement in preparation, review, or approval of the manuscript for publication. PR (the corresponding author) had final responsibility for the decision to submit for publication.

Published
2016

3. Designing phase 3 sepsis trials: application of learned experiences from critical care trials in acute heart failure

Author

Oliver Hartmann, Mathias Schroedter, John C. Marshall, Roger J. Lewis, Gernot Marx, Frauke Hein, Pierre-François Laterre, Joachim Struck, James A. Russell, Anne Louise Kjølbye, Peter Radermacher, Greet Van den Berghe, Paul Scigalla, Luciano Gattinoni, Mehmet Yilmaz, Michael O. Harhay, Etienne Gayat, Wendy Gattis Stough, Derek C. Angus, Andreas Bergmann, Alexandre Mebazaa, Matthieu Legrand, HAL UPMC, Gestionnaire, Hôpital Lariboisière, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Université Paris Diderot - Paris 7 (UPD7), Biomarqueurs CArdioNeuroVASCulaires (BioCANVAS), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Catholique de Louvain = Catholic University of Louvain (UCL), University of British Columbia (UBC), Adrenomed AG, Università degli Studi di Milano = University of Milan (UNIMI), University of Pennsylvania, Ferring Pharmaceuticals A/S, Harbor UCLA Medical Center [Torrance, Ca.], University of Toronto, Rheinisch-Westfälische Technische Hochschule Aachen University (RWTH), Universitätsklinikum Ulm - University Hospital of Ulm, Campbell University College, Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Cumhuriyet Universitesi, University of Pittsburgh (PITT), Pennsylvania Commonwealth System of Higher Education (PCSHE), UCL - (SLuc) Service de soins intensifs, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, [Mebazaa, Alexandre] Univ Paris Diderot, Sorbonne Paris Cite, Paris, France -- [Mebazaa, Alexandre] AP HP, INSERM, U942, Paris, France -- [Mebazaa, Alexandre] Hop Univ St Louis Lariboisiere, AP HP, Dept Anesthesia & Crit Care, Paris, France -- [Laterre, Pierre Francois] Catholic Univ Louvain, St Luc Univ Hosp, Dept Crit Care Med, B-1200 Brussels, Belgium -- [Russell, James A.] Univ British Columbia, Ctr Heart Lung Innovat, St Pauls Hosp, Vancouver, BC V5Z 1M9, Canada -- [Russell, James A.] Univ British Columbia, St Pauls Hosp, Div Crit Care Med, Vancouver, BC V5Z 1M9, Canada -- [Bergmann, Andreas -- Hartmann, Oliver -- Hein, Frauke -- Schroedter, Mathias -- Scigalla, Paul -- Struck, Joachim] Adrenomed AG, Hennigsdorf, Germany -- [Gattinoni, Luciano] Univ Milan, Fdn IRCCS Ca Granda, Osped Maggiore Policlin, Milan, Italy -- [Gayat, Etienne] Univ Paris Diderot, Hop Univ St Louis Lariboisiere, AP HP, Dept Anesthesie Reanimat SMUR,INSERM,UMR 942, Paris, France -- [Harhay, Michael O.] Univ Penn, Dept Biostat & Epidemiol, Perelman Sch Med, Div Epidemiol, Philadelphia, PA 19104 USA -- [Kjolbye, Anne Louise] Ferring Pharmaceut, Copenhagen, Denmark -- [Legrand, Matthieu] Univ Paris 07, St Louis Hosp, UMR S942, Dept Anesthesiol,Crit Care & Burn Unit, Paris, France -- [Lewis, Roger J.] Harbor UCLA Med Ctr, Dept Emergency Med, Torrance, CA 90509 USA -- [Marshall, John C.] Univ Toronto, St Michaels Hosp, Dept Surg, Interdept Div Crit Care Med, Toronto, ON, Canada -- [Marx, Gernot] Univ Hosp RWTH Aachen, Dept Intens Care & Intermediate Care, Aachen, Germany -- [Radermacher, Peter] Univ Ulm Klinikum, Inst Anasthesiol Pathophysiol & Verfahrensentwick, Ulm, Germany -- [Stough, Wendy Gattis] Campbell Univ, Coll Pharm & Hlth Sci, Buies Creek, NC 27506 USA -- [Van den Berghe, Greet] Katholieke Univ Leuven, Div Cellular & Mol Med, Clin Dept, Leuven, Belgium -- [Van den Berghe, Greet] Katholieke Univ Leuven, Div Cellular & Mol Med, Lab Intens Care Med, Leuven, Belgium -- [Yilmaz, Mehmet Birhan] Cumhuriyet Univ, Fac Med, Dept Cardiol, Sivas, Turkey -- [Angus, Derek C.] Univ Pittsburgh, Sch Hlth Sci, Clin & Translat Sci Inst, CRISMA Ctr,Dept Crit Care Med,McGowan Inst Regner, Pittsburgh, PA USA -- [Angus, Derek C.] Univ Pittsburgh, Sch Hlth Sci, Clin & Translat Sci Inst, Dept Hlth Policy & Management,McGowan Inst Regene, Pittsburgh, PA USA, Van den Berghe, Greet -- 0000-0002-5320-1362, YILMAZ, Mehmet Birhan -- 0000-0002-8169-8628, YILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628, Harhay, Michael -- 0000-0002-0553-674X, GAYAT, Etienne -- 0000-0002-3334-3849, Gattinoni, Luciano -- 0000-0001-5380-2494, Mebazaa, Alexandre -- 0000-0001-8715-7753, Università degli Studi di Milano [Milano] (UNIMI), University of Pennsylvania [Philadelphia], and Rheinisch-Westfälische Technische Hochschule Aachen (RWTH)

Subjects
medicine.medical_specialty, Clinical Sciences, Psychological intervention, Heart failure, Review, 030204 cardiovascular system & hematology, Critical Care and Intensive Care Medicine, Phase (combat), Sepsis, 03 medical and health sciences, Clinical trials as topic, 0302 clinical medicine, medicine, 030212 general & internal medicine, Mortality, Intensive care medicine, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Septic shock, business.industry, Organ dysfunction, medicine.disease, Multiple organ failure, 3. Good health, Clinical trial, Etiology, medicine.symptom, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

WOS: 000373260700001, PubMed ID: 27034779, Substantial attention and resources have been directed to improving outcomes of patients with critical illnesses, in particular sepsis, but all recent clinical trials testing various interventions or strategies have failed to detect a robust benefit on mortality. Acute heart failure is also a critical illness, and although the underlying etiologies differ, acute heart failure and sepsis are critical care illnesses that have a high mortality in which clinical trials have been difficult to conduct and have not yielded effective treatments. Both conditions represent a syndrome that is often difficult to define with a wide variation in patient characteristics, presentation, and standard management across institutions. Referring to past experiences and lessons learned in acute heart failure may be informative and help frame research in the area of sepsis. Academic heart failure investigators and industry have worked closely with regulators for many years to transition acute heart failure trials away from relying on dyspnea assessments and all-cause mortality as the primary measures of efficacy, and recent trials have been designed to assess novel clinical composite endpoints assessing organ dysfunction and mortality while still assessing all-cause mortality as a separate measure of safety. Applying the lessons learned in acute heart failure trials to severe sepsis and septic shock trials might be useful to advance the field. Novel endpoints beyond all-cause mortality should be considered for future sepsis trials., NHLBI NIH HHS [F31 HL127947]

Published
2016
Full Text
View/download PDF

4. Mortality and acute exacerbation of COPD: a pilot study on the influence of myocardial injury

Author

Richard W. Troughton, Said Laribi, Erwin Hansconrad, Justina Motiejunaite, Mehmet Yilmaz, Christian Mueller, Semir Nouira, Kenan Ahmet Turkdogan, Agim Beshiri, Wenjia Chen, Zaid Sabti, Chris J. Pemberton, Alexandre Mebazaa, J. Mark FitzGerald, Jean-Marie Launay, Malha Sadoune, Lyndsey Kirwan, Mercedes Rivas-Lasarte, Corinne Collet, Patrick Plaisance, Mark Richards, Etienne Gayat, Biomarqueurs CArdioNeuroVASCulaires (BioCANVAS), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de Médecine d'Urgence [CHU Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Ecole de Médecine [Tours], Université de Tours (UT), Department of Medicine [Christchurch, New Zealand], University of Otago [Dunedin, Nouvelle-Zélande], Emergency Dept and Research Unit UR06SP21 [Monastir, Tunisia], CHU Fattouma Bourguiba [Monastir] (HFB), Department of Emergeny Medicine [Aydin, Turkey], Adnan Menderes Üniversitesi, Department of Cardiology [Sivas, Turkey], Cumhuriyet University [Sivas, Turkey], Université Sorbonne Paris Cité (USPC), Service d'Anesthésie-Réanimation [AP-HP Hôpitaux Saint-Louis Lariboisière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Cardiology Department [Barcelona, Spain], Hospital de la Santa Creu i Sant Pau, Department of Internal Medicine [Basel, Switzerland], University Hospital Basel [Basel], Département de Médecine d'Urgence [AP-HP Hôpitaux universitaires Saint-Louis, Lariboisière, Fernand-Widal], AP-HP Hôpitaux universitaires Saint-Louis, Lariboisière, Fernand-Widal, Department of Cardiology [Kaunas, Lithuania], Hospital of Lithuanian University of Health Sciences Kauno Klinikos [Kaunas, Lithuania], Medical and Scientific Affairs [Abbott Park, IL, USA], Abbott Laboratories, Respiratory Division [Vancouver, BC, Canada], University of British Columbia - UBC [Vancouver, BC, Canada], Service de Biochimie [AP-HP Hôpitaux Saint-Louis Lariboisière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], UBC and VGH Divisions of Respiratory Medicine [Vancouver, BC, Canada], St. Paul’s Hospital - University of British Columbia [Vancouver, BC, Canada]-Institute for Heart and Lung Health [Vancouver, BC, Canada], Cardiovascular Research Institute [Singapour], National University of Singapore (NUS), Vilnius University [Lithuania], This study was funded by ThermoFisher. A. Mebazaa and J. Motiejunaite would like to acknowledgethe support of the Research Council of Lithuania, grant number MIP-049/2015., Université Paris Diderot - Paris 7 (UPD7), Service de biochimie INSERM UMR-S942, Hôpital Lariboisière-APHP, Service des Urgences, Hôpital Lariboisière, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Institut fuer Theoretische Physik (Institut fuer Theoretische Physik), Universität Heidelberg [Heidelberg], U942, Hop Lariboisiere, AP HP,Dept Biochem, Institut National de la Santé et de la Recherche Médicale (INSERM), Département d'Anesthésie Réanimation SMUR [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], St. Paul’s Hospital - University of British Columbia [Vancouver, BC, Canada] (SPH-UBC)-Institute for Heart and Lung Health [Vancouver, BC, Canada], Mebazaa, Alexandre, Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Université de Tours, Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), [Laribi, Said] Francois Rabelais Univ, Sch Med, Tours, France -- [Laribi, Said] Tours Univ Hosp, Emergency Med Dept, Tours, France -- [Laribi, Said -- Kirwan, Lyndsey -- Gayat, Etienne -- Rivas-Lasarte, Mercedes -- Sadoune, Malha -- Motiejunaite, Justina -- Plaisance, Patrick -- Launay, Jean-Marie -- Mebazaa, Alexandre] INSERM, U942, BIOmarkers CArdioNeuroVASc Dis, Paris, France -- [Pemberton, Chris J. -- Troughton, Richard W. -- Richards, Mark] Univ Otago, Dept Med, Christchurch Heart Inst, Christchurch, New Zealand -- [Nouira, Semir] Fattouma Bourguiba Univ Hosp, Emergency Dept, Monastir, Tunisia -- [Nouira, Semir] Fattouma Bourguiba Univ Hosp, Res Unit UR06SP21, Monastir, Tunisia -- [Turkdogan, Kenan] Adnan Menderes Univ, Fac Med, Dept Emergeny Med, Aydin, Turkey -- [Yilmaz, Mehmet Birhan] Cumhuriyet Univ, Fac Med, Dept Cardiol, Sivas, Turkey -- [Gayat, Etienne -- Plaisance, Patrick -- Mebazaa, Alexandre] Univ Paris Diderot, Sorbonne Paris Cite, Paris, France -- [Gayat, Etienne -- Motiejunaite, Justina -- Mebazaa, Alexandre] St Louis Lariboisiere Hosp, AP HP, Dept Anesthesiol & Crit Care, Paris, France -- [Rivas-Lasarte, Mercedes] Univ Autonoma Barcelona, Biomed Res Inst IIB St Pau, Hosp Santa CreuiSt Pau, Cardiol Dept, Barcelona, Spain -- [Sabti, Zaid -- Mueller, Christian] Univ Hosp, Dept Internal Med, Basel, Switzerland -- [Hansconrad, Erwin -- Plaisance, Patrick] St Louis Lariboisiere Hosp, AP HP, Emergency Med Dept, Paris, France -- [Motiejunaite, Justina] Lithuanian Univ Hlth Sci Kauno Klinikos, Dept Cardiol, Kaunas, Lithuania -- [Beshiri, Agim] Abbott Labs, Abbott Pk, IL 60064 USA -- [Chen, Wenjia] Univ British Columbia, Resp Div, Inst Heart & Lung Hlth, Vancouver, BC, Canada -- [Collet, Corinne] St Louis Lariboisiere Hosp, AP HP, Dept Biochem, Paris, France -- [FitzGerald, J. Mark] Inst Heart & Lung Hlth, UBC Div Resp Med, Vancouver, BC, Canada -- [FitzGerald, J. Mark] Inst Heart & Lung Hlth, VGH Div Resp Med, Vancouver, BC, Canada -- [Richards, Mark] Natl Univ Singapore, Cardiovasc Res Inst, Singapore, Singapore -- [Mebazaa, Alexandre] Vilnius Univ, Vilnius, Lithuania, YILMAZ, Mehmet Birhan -- 0000-0002-8169-8628, YILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628, Chen, Wenjia -- 0000-0001-8201-7145, GAYAT, Etienne -- 0000-0002-3334-3849, Mebazaa, Alexandre -- 0000-0001-8715-7753, and collet, corinne -- 0000-0001-6990-863X

Subjects
Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Exacerbation, [SDV]Life Sciences [q-bio], Pilot Projects, 030204 cardiovascular system & hematology, Severity of Illness Index, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, law.invention, Cohort Studies, Pulmonary Disease, Chronic Obstructive, 03 medical and health sciences, 0302 clinical medicine, Copeptin, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Interquartile range, law, Internal medicine, Natriuretic Peptide, Brain, medicine, Humans, Myocardial infarction, Intensive care medicine, ComputingMilieux_MISCELLANEOUS, Aged, COPD, business.industry, Myocardium, Mortality rate, Glycopeptides, Middle Aged, Prognosis, medicine.disease, Intensive care unit, Troponin, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, 3. Good health, 030228 respiratory system, Cohort, Regression Analysis, [SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Female, Cardiomyopathies, business, Biomarkers
Abstract

WOS: 000404447400031, PubMed ID: 28663316, …, ThermoFisher; Research Council of Lithuania [MIP-049/2015]; Crossref Funder Registry, This study was funded by ThermoFisher. A. Mebazaa and J. Motiejunaite would like to acknowledge the support of the Research Council of Lithuania, grant number MIP-049/2015. Funding information for this article has been deposited with the Crossref Funder Registry.

Published
2017
Full Text
View/download PDF

5. Impact of diuretic dosing on mortality in acute heart failure using a propensity-matched analysis

Author

Etienne Gayat, Ferenc Follath, Maria Nikolaou, John Parissis, Said Laribi, W. Franck Peacock, Reda Salem, Alexandre Mebazaa, Mehmet Yilmaz, Johan Lassus, [Yilmaz, Mehmet Birhan -- Mebazaa, Alexandre] Lariboisiere Hosp, INSERM, U942, Paris, France -- [Yilmaz, Mehmet Birhan] Cumhuriyet Univ, Sch Med, Dept Cardiol, Sivas, Turkey -- [Gayat, Etienne -- Salem, Reda] Univ Paris 07, Hop Lariboisiere, APHP, Dept Anesthesiol & Crit Care Med,U717,INSERM, Paris, France -- [Lassus, Johan] Univ Helsinki, Cent Hosp, Div Cardiol, Dept Med, Helsinki, Finland -- [Nikolaou, Maria -- Parissis, John] Attikon Univ Hosp, Dept Cardiol 2, Athens, Greece -- [Laribi, Said] Univ Paris 07, INSERM, Dept Emergency, Lariboisiere Hosp,U942, Paris, France -- [Parissis, John] Attikon Univ Hosp, Heart Failure Clin, Athens, Greece -- [Follath, Ferenc] Univ Zurich Hosp, Dept Internal Med, Zurich, Switzerland -- [Peacock, W. Franck] Cleveland Clin, Emergency Med Inst, Cleveland, OH 44106 USA -- [Mebazaa, Alexandre] Hop Lariboisiere, APHP, Dept Anesthesiol & Crit Care, F-75475 Paris, France, YILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628, YILMAZ, Mehmet Birhan -- 0000-0002-8169-8628, GAYAT, Etienne -- 0000-0002-3334-3849, and Mebazaa, Alexandre -- 0000-0001-8715-7753

Subjects
medicine.medical_specialty, Acute coronary syndrome, medicine.medical_treatment, Bolus (medicine), Diuretic dose, Sodium Potassium Chloride Symporter Inhibitors, Furosemide, Internal medicine, medicine, Humans, Dosing, Propensity Score, Intensive care medicine, Retrospective Studies, Outcome, Heart Failure, Ejection fraction, Dose-Response Relationship, Drug, business.industry, Acute heart failure, medicine.disease, Health Care Surveys, Heart failure, Acute Disease, Propensity score matching, Cardiology, Diuretic, Cardiology and Cardiovascular Medicine, business, medicine.drug
Abstract

WOS: 000296318900014, PubMed ID: 22024466, Aims Loop diuretics are recommended to treat congestion in heart failure (HF), despite limited quality evidence. High-dose (HD) loop diuretics seem to worsen outcomes in chronic HF, though; data for acute HF are scarce, with equivocal results. Methods and results The ALARM-HF study recorded in-hospital HF therapy in 4953 patients from nine countries. A post-hoc analysis was performed to determine if there was an interaction between intravenous (iv) bolus diuretic dosing and outcomes. Patients were classified as receiving high-or low-dose iv furosemide if their total initial 24 h dose was above (HD) or below [low dose (LD)] 1 mg/kg. Propensity scoring, matching an extensive list of variables, was performed. High-dose and LD patients were matched by propensity scores and outcomes determined. We identified 2460 LD and 848 HD patients, with overall in-hospital mortality of 9 and 13% (P = 0.002), respectively. After propensity matching, there were 506 patients in each subgroup, with the matched LD and HD cohorts having similar mortality (13 vs. 15%; P = 0.4). We further investigated in which subgroups of patients HD diuretics influenced mortality. Before matching, HD diuretics were associated with a greater risk of in-hospital death in some subgroups, including patients aged >80 years, those with an acute coronary syndrome, or with a left ventricular ejection fraction, ALARM-HF survey; Department of Biostatistics and Clinical Epidemiology; INSERM [U717]; St-Louis Hospital, France; Abbott; Alere; BAS; Brahms; EKR; Nanosphere; Medicines Company; Orion Pharma, Abbott funded the ALARM-HF survey; data were acquired by IMS. Analyses were performed independently of the funding source by the Department of Biostatistics and Clinical Epidemiology, INSERM U717, St-Louis Hospital, France.; J.P. has received honoraria as a speaker or advisor from Orion Pharma Finland and Abbott USA. W.F.P. has received research grants from Abbott, Alere, BAS, Brahms, EKR, Nanosphere, and the Medicines Company; is a consultant for Abbott, Alere, Beckman Coulter, Electroclore, and The Medicines Company, serves on the speakers bureau of Abbott and Alere and has ownership interests in Comprehensive Research Associates LLC, Vital Sensors and Emergencies in Medicine LLC. A.M. has received lecture fees from Orion Pharma.

Published
2011

6. Clinical presentation, management and outcomes in the Acute Heart Failure Global Survey of Standard Treatment (ALARM-HF)

Author

Etienne Gayat, Fábio Vilas-Boas, Nigel Burrows, John Parissis, Alexandre Mebazaa, Juan F. Delgado, Raphaël Porcher, Mehmet Yilmaz, Anthony S. McLean, Ferenc Follath, [Follath, F.] Univ Zurich Hosp, Dept Internal Med, Off HAL 18 D2, CH-8091 Zurich, Switzerland -- [Yilmaz, M. B.] Cumhuriyet Univ, Sch Med, Dept Cardiol, Sivas, Turkey -- [Yilmaz, M. B.] Hosp Lariboisiere, INSERM, U942, Paris, France -- [Delgado, J. F.] Hosp Doce de Octubre, Heart Failure & Transplant Unit, Dept Cardiol, Madrid, Spain -- [Parissis, J. T.] Attikon Univ Hosp, Heart Failure Clin, Athens, Greece -- [Parissis, J. T.] Attikon Univ Hosp, Cardiol Dept 2, Athens, Greece -- [Porcher, R. -- Gayat, E.] Univ Paris 07, Dept Biostat & Informat Med, Hop St Louis, AP HP,INSERM,UMR S 717, Paris, France -- [Burrows, Nigel] IMS Hlth SpA, Milan, Italy -- [Mclean, A.] Univ Sydney, Dept Intens Care Med, Nepean Hosp, Penrith, NSW, Australia -- [Vilas-Boas, F.] Hosp Espanhol, Div Cardiol, Salvador, BA, Brazil -- [Vilas-Boas, F.] Hosp Espanhol, Heart Failure & Transplantat Program, Salvador, BA, Brazil -- [Mebazaa, A.] Hosp Lariboisiere, AP HP, Dept Anesthesiol & Crit Care Med, Paris, France -- [Mebazaa, A.] Univ Paris 07, INSERM, U942, Paris, France, YILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628, YILMAZ, Mehmet Birhan -- 0000-0002-8169-8628, Delgado, Juan F. -- 0000-0002-5401-8324, Porcher, Raphael -- 0000-0002-5277-4679, GAYAT, Etienne -- 0000-0002-3334-3849, Mebazaa, Alexandre -- 0000-0001-8715-7753, University of Zurich, and Follath, F

Subjects
Male, medicine.medical_specialty, Internationality, Acute heart failure syndromes, 610 Medicine & health, Critical Care and Intensive Care Medicine, law.invention, law, Intensive care, Internal medicine, Surveys and Questionnaires, Outcome Assessment, Health Care, Medicine, Humans, Hospital Mortality, Aged, Aged, 80 and over, Heart Failure, Ejection fraction, business.industry, Standard treatment, Cardiogenic shock, Levosimendan, Middle Aged, medicine.disease, Classification, Prognosis, Intensive care unit, Surgery, Management, Intensive Care Units, Heart failure, Acute Disease, Dobutamine, Female, Therapy, 10029 Clinic and Policlinic for Internal Medicine, 2706 Critical Care and Intensive Care Medicine, business, medicine.drug
Abstract

WOS: 000289305700010, PubMed ID: 21210078, Purpose: We performed a survey on acute heart failure (AHF) in nine countries in four continents. We aimed to describe characteristics and management of AHF among various countries, to compare patients with de novo AHF versus patients with a pre-existing episode of AHF, and to describe subpopulations hospitalized in intensive care unit (ICU) versus cardiac care unit (CCU) versus ward. Methods and results: Data from 4,953 patients with AHF were collected via questionnaire from 666 hospitals. Clinical presentation included decompensated congestive HF (38.6%), pulmonary oedema (36.7%) and cardiogenic shock (11.7%). Patients with de novo episode of AHF (36.2%) were younger, had less comorbidities and lower blood pressure despite greater left ventricular ejection fraction (LVEF) and were more often admitted to ICU. Overall, intravenous (IV) diuretics were given in 89.7%, vasodilators in 41.1%, and inotropic agents (dobutamine, dopamine, adrenaline, noradrenaline and levosimendan) in 39% of cases. Overall hospital death rate was 12%, the majority due to cardiogenic shock (43%). More patients with de novo AHF (14.2%) than patients with a pre-existing episode of AHF (10.8%) (p = 0.0007) died. There was graded mortality in ICU, CCU and ward patients with mortality in ICU patients being the highest (17.8%) (p < 0.0001). Conclusions: Our data demonstrated the existence of different subgroups based on de novo or pre-existing episode(s) of AHF and the site of hospitalization. Recognition of these subgroups might improve management and outcome by defining specific therapeutic requirements., TUBITAK (Turkey); Abbott, All coauthors would like to thank Patrick Cepon, Helen Smith, Ches Manly and Melinda Swan for their support. MB Yilmaz received a grant from TUBITAK (Turkey).; Abbott funded the ALARM-HF survey; data were acquired by IMS. Analyses were performed by Departement de Biostatistique et Informatique Medicale, Hopital Saint-Louis, APHP; Universite Paris 7; INSERM - UMR-S 717, Paris France by RP and EG. AM, JP, FVB, JFD and FF received honorarium from Abbott for lectures and/or consulting.

Published
2009

Catalog

Books, media, physical & digital resources
See catalog results