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When single-phase ground faults occur in distribution systems, the fault characteristics of zero-sequence current signals are not prominent. They are quickly submerged in noise, leading to difficulties in fault section location. This paper proposes a method for fault section location in distribution networks based on improved empirical wavelet transform (IEWT) and GINs to address this issue. Firstly, based on kurtosis, EWT is optimized using the N-point search method to decompose the zero-sequence current signal into modal components. Noise is filtered out through weighted permutation entropy (WPE), and signal reconstruction is performed to obtain the denoised zero-sequence current signal. Subsequently, GINs are employed for graph classification tasks. According to the topology of the distribution network, the corresponding graph is constructed as the input to the GIN. The denoised zero-sequence current signal is the node input for the GIN. The GIN autonomously explores the features of each graph structure to achieve fault section location. The experimental results demonstrate that this method has strong noise resistance, with a fault section location accuracy of up to 99.95%, effectively completing fault section location in distribution networks. [ABSTRACT FROM AUTHOR]

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The Gastroenterology Immunology Neuroscience (GIN) Discovery Program represents a new model for research that overcomes the limitations imposed by traditional "research silos" in science. By uniting these three fields, the GIN Program aims to enhance the understanding and treatment of chronic conditions through a system‐wide perspective focusing on the gut–immune–brain axis. Key initiatives include monthly interdisciplinary seminars, an annual symposium, and GINnovate, a commercialization and entrepreneurship event. Additionally, the program offers a seed grant competition for early and mid‐career researchers, promoting advancements in gut–immune–brain axis research through the power of collaboration. The GIN Program in a short period of time has facilitated the formation of a vibrant community, captivating attention from both national and international institutions. This effort to break down barriers in research aims to inspire similar models that prioritize open communication, mutual respect and a commitment to impactful science. [ABSTRACT FROM AUTHOR]

Exponential growth of news content on social media makes it easy to know the recent updates but confidence to get genuine or fake news is uncertain. Often these uncertainties are so convincing and undetectable by cautious human inspection. In the present work, a peculiar feature of social media –the news propagation graph is considered an evident feature for news identification due to the exposure of varying content dissemination patterns of fake and real news through these propagation graphs. In the article, news content features and user profile features are embedded with nodes, and a tweet-retweet network is used to model the propagation graph of fake/real news in the social network. Further, a specialized variant of graph neural network- graph isomorphic network has been used to develop the Graph Isomorphic Network Fake News Detection (GIN-FND) model. The isomorphic network-based similarity in propagation graph for fake news detection of news is validated on word embedding features (SpaCy and LargeBERT) and user profile features. Results show the overall outstanding performance of the proposed GIN-FND model in comparison with the existing graph neural network model for fake news detection. GIN-FND achieved the best accuracy by making use of SpaCy features is 98.63% and 85.48% for the training dataset, 95.24% and 77.42% for validation, 95.61 and 79.64% for the test dataset of Gossip Cop and PolitiFact respectively. [ABSTRACT FROM AUTHOR]

During the course of the nineteenth century the island of Kythera, Southwest Greece, was part of the United States of Ionian Islands, under the control of the British empire. This paper explores the materiality of colonialism in local contexts, through the object itineraries of a group of stoneware bottles—a class of artefacts that continues to be represented in domestic assemblages locally today. We examine the diverse ways the vessels became entangled with the lives of individuals, colonialist agendas, and collective perceptions of identity, seeking to identify how the meanings associated with the objects and their relational connections shifted across time and space. [ABSTRACT FROM AUTHOR]

Bacterial RecJ exhibits 5′→3′ exonuclease activity that is specific to ssDNA; however, archaeal RecJs show 5′ or 3′ exonuclease activity. The hyperthermophilic archaea Methanocaldococcus jannaschii encodes the 5′-exonuclease MjRecJ1 and the 3′-exonuclease MjRecJ2. In addition to nuclease activity, archaeal RecJ interacts with GINS, a structural subcomplex of the replicative DNA helicase complex. However, MjRecJ1 and MjRecJ2 do not interact with MjGINS. Here, we report the structural basis for the inability of the MjRecJ2 homologous dimer to interact with MjGINS and its efficient 3′ hydrolysis polarity for short dinucleotides. Based on the crystal structure of MjRecJ2, we propose that the interaction surface of the MjRecJ2 dimer overlaps the potential interaction surface for MjGINS and blocks the formation of the MjRecJ2-GINS complex. Exposing the interaction surface of the MjRecJ2 dimer restores its interaction with MjGINS. The cocrystal structures of MjRecJ2 with substrate dideoxynucleotides or product dCMP/CMP show that MjRecJ2 has a short substrate binding patch, which is perpendicular to the longer patch of bacterial RecJ. Our results provide new insights into the function and diversification of archaeal RecJ/Cdc45 proteins. [ABSTRACT FROM AUTHOR]

In this study, we investigate the influence of global innovation networks (GINs) on the innovation output of semiconductor firms. Utilizing negative binomial regression and network analysis, we assess how network positions, specifically degree, betweenness, and closeness centrality, affect firms' innovation performance, revealing significant positive impacts. Moreover, our results identify a positive U-shaped relationship between structural holes in GINs and innovation performance, suggesting that while moderate network engagement aids innovation, too much can be detrimental. This research provides key insights into optimizing GIN participation for better innovation results in the competitive semiconductor sector. [ABSTRACT FROM AUTHOR]

This study introduces a novel methodology for evaluating volatile-compound-based compatibility in 160 botanicals essential for gin production. It establishes a comprehensive botanical pairing system through network analysis, mathematical modeling, and indicator development. Key findings include the benefits of strategic botanical inclusions to recipes for compatibility improvement and a numerical compatibility assessment, revealing an average indicator of 1.78 across thirty validated gin recipes, with a significant threshold at 1.36 indicating superior compatibility. Additionally, two distinct indicators were formulated--one focusing on the percentage of shared compounds due to a specific botanical and another on the botanical's representation in the recipe. A visual network analysis replaces the traditional aroma classification wheel, offering a comprehensive view of aromatic profiles. This research transforms gin formulation, supported by an extensive database and validated methods. [ABSTRACT FROM AUTHOR]

Why was the work done: The influence of distillation time on the volatile composition of gin has not been examined in detail at a commercial distillery. How was the work done: Headspace Solid-Phase Micro-Extraction Gas Chromatography-Mass Spectrometry (HS-SPME-GC-MS) was used to tentatively identify 74 aroma compounds, with their concentration tracked in distillate samples over the course of three gin distillations. What are the main findings: Four unique fractions were identified using Agglomerative Hierarchical Clustering: 'heads', 'early hearts', 'late hearts, and 'tails'. The hearts fraction (n=24 samples) was examined further, fitting statistically appropriate models to 54 aroma volatiles. Three sub-groups of volatiles were identified, (i) highly volatile monoterpenes with rapidly decreasing concentration over the early hearts fraction, (ii) volatiles whose concentration increased gradually over the hearts fraction and (iii) less volatile sesquiterpenes, sesquiterpenoids, and monoterpenoids which increased rapidly in concentration in the later distillate. Complex cubic models fit 34 volatiles with very high significance (p>0.0001) over the hearts fraction (72%). Informal aroma sensory bench testing identified distinct aroma categories with, for example, 'Spicy' being commonly detected in the later distillate. Why is the work important: This investigation characterises the kinetics of flavour extraction over the course of a commercial gin distillation process. These findings highlight the potential for the expression of specific flavour characteristics by modifying the cut points of the distillation process. [ABSTRACT FROM AUTHOR]

The aim of this study was to investigate how the activity of cattle under natural grazing conditions is related to their individual parasite contribution (IPC). Potentially, the individuals contributing the most to the contamination of the pasture with gastrointestinal nematodes (GIN) could then be identified and selectively treated based on sensor data thresholds. A total of 58 steers of the dairy breeds Swedish Red (SR, n = 19) and Swedish Holstein (SH, n = 39) were used for sensor-based data collection that lasted for a total of 10 weeks from 4 May to 13 July 2022. All steers were inoculated with a priming dose of nematode larvae and weighed in conjunction with the pasture release. The animals were then divided into four experimental groups and treated with ivermectin (IVM PO, Boehringer Ingelheim, 0.5 mg/kg BW) at different intervals to obtain an exposure contrast (Group A was left untreated, Group B/IVM PO-4w was treated after 4 weeks, Group C/IVM PO-8w was treated after 8 weeks, and Group D/IVM PO-4&8w was treated after 4 weeks and then after 8 weeks). The steers were weighed on four further occasions, during which faecal samples were also taken for parasite testing. Activity data were collected using leg-mounted IceQube sensors and body weight data and faecal samples were collected bi-weekly. The new threshold metric (IPC) was proposed for individuals with different faecal egg count (FEC) levels [NO (no contribution) <20 EPG, LO (low contribution) = 20–150 EPG, ME (medium contribution) = 150–250 EPG, and HI (high contribution) ≥250 EPG] The effects of IPC on activity patterns were analysed stepwise using a Generalised Estimating Equations model implemented in Python programming language. Results showed significant effects of different IPC values on motion index and number of steps taken (adjusted p-value of 0.008, 0.018, 0.041, and 0.001 for individuals with NO, LO, ME, and HI IPC values, respectively). There were some breed effects on the average number of steps and minutes spent lying. The results also provide alternative threshold methods aimed at finding more sustainable ways of using anthelmintics and integrating individual data into future parasite control strategies. [ABSTRACT FROM AUTHOR]

Activation of the replicative Mcm2-7 helicase by loading GINS and Cdc45 is crucial for replication origin firing, and as such for faithful genetic inheritance. Our biochemical and structural studies demonstrate that the helicase activator GINS interacts with TopBP1 through two separate binding surfaces, the first involving a stretch of highly conserved amino acids in the TopBP1-GINI region, the second a surface on TopBP1-BRCT4. The two surfaces bind to opposite ends of the A domain of the GINS subunit Psf1. Mutation analysis reveals that either surface is individually able to support TopBP1-GINS interaction, albeit with reduced affinity. Consistently, either surface is sufficient for replication origin firing in Xenopus egg extracts and becomes essential in the absence of the other. The TopBP1-GINS interaction appears sterically incompatible with simultaneous binding of DNA polymerase epsilon (Polε) to GINS when bound to Mcm2-7-Cdc45, although TopBP1-BRCT4 and the Polε subunit PolE2 show only partial competitivity in binding to Psf1. Our TopBP1-GINS model improves the understanding of the recently characterised metazoan pre-loading complex. It further predicts the coordination of three molecular origin firing processes, DNA polymerase epsilon arrival, TopBP1 ejection and GINS integration into Mcm2-7-Cdc45. Effective and regulated activation of the Mcm2-7 helicase underlies faithful genome replication. Here the authors reveal mechanistic detail how the pre-loading complex proteins TopBP1 and GINS interact and, thus, how the helicase activator GINS loads on Mcm2-7 during replication origin firing. [ABSTRACT FROM AUTHOR]

Simple Summary: Gastrointestinal nematode (GIN) infection in sheep is a common problem affecting small and large farms worldwide. These GIN parasites will normally infect the intestine of a sheep and may lead to diarrhea, weight loss, anemia and, in some cases, the animal's death. The animals can also present a decrease in meat, wool, and milk production, which will lead to substantial economic losses. The use of anthelmintics to treat infected sheep as a single approach has resulted in worms developing resistance against the available commercial drugs. Other studies have shown that the animals resistant to GIN infection are capable of coping with the infection and have reduced health impairment caused by the GIN parasites. In this review, we summarize the results from the literature on the estimated genetic parameters for traits assessing GIN resistance in sheep. Additionally, we summarize the possible genetic gains when sheep are selected to be resistant to GIN and how genetics and genomics have impacted breeding programs in different countries. Gastrointestinal nematodes (GINs) are a major problem affecting sheep production systems worldwide. The flocks infected with GINs can undergo significant economic losses due to a decrease in productivity, the animals' deaths, and the costs associated with treatments. The over-reliance on anthelmintics in the past years to eliminate GINs has resulted in the development of resistance against the available commercial anthelmintics. Genetically resistant animals can be used in mating systems to improve the overall flock resistance. This review aimed to summarize the estimated genetic parameters for resistance traits and genetic gains through the use of genetic/genomic selection for resistance to GINs in sheep. Heritability estimates from the literature ranged from 0.00 to 0.46 for fecal egg counts, 0.12 to 0.37 for packed cell volume/hematocrit, 0.07 to 0.26 for FAffa MAlan CHArt (FAMACHA©), from 0.10 to 0.37 for blood parameters, and 0.19 for Immunoglobulin A. Genetic correlations between traits measuring resistance to GINs and production traits ranged from negative to positive values in the literature. Genetic gains are possible when genetic/genomic selection for GIN resistance is applied. Therefore, genetic/genomic selection can be used to improve flocks' resistance to GINs as a sustainable approach in sheep production systems. [ABSTRACT FROM AUTHOR]

The aim of this study was to investigate how the activity of cattle under natural grazing conditions is related to their individual parasite contribution (IPC). Potentially, the individuals contributing the most to the contamination of the pasture with gastrointestinal nematodes (GIN) could then be identified and selectively treated based on sensor data thresholds. A total of 58 steers of the dairy breeds Swedish Red (SR, n = 19) and Swedish Holstein (SH, n = 39) were used for sensor-based data collection that lasted for a total of 10 weeks from 4 May to 13 July 2022. All steers were inoculated with a priming dose of nematode larvae and weighed in conjunction with the pasture release. The animals were then divided into four experimental groups and treated with ivermectin (IVM PO, Boehringer Ingelheim, 0.5 mg/kg BW) at different intervals to obtain an exposure contrast (Group A was left untreated, Group B/IVM PO-4w was treated after 4 weeks, Group C/IVM PO-8w was treated after 8 weeks, and Group D/IVM PO-4&8w was treated after 4 weeks and then after 8 weeks). The steers were weighed on four further occasions, during which faecal samples were also taken for parasite testing. Activity data were collected using leg-mounted IceQube sensors and body weight data and faecal samples were collected bi-weekly. The new threshold metric (IPC) was proposed for individuals with different faecal egg count (FEC) levels [NO (no contribution)

To describe the gross and ultrasound anatomy of the parasacral region and an ultrasound-guided greater ischiatic notch (GIN) plane approach aimed at staining the lumbosacral trunk (LST) in canine cadavers. To evaluate if the ultrasound-guided GIN plane approach is non-inferior to the previously described ultrasound-guided parasacral approach at staining the LST. Prospective, randomized, non-inferiority experimental anatomic study. A total of 17 (23.9 ± 5.2 kg) mesocephalic canine cadavers. Anatomic and echographic landmarks, and the feasibility of performing a GIN plane technique were evaluated using two canine cadavers. The remaining 15 cadavers had each hemipelvis randomly assigned to be administered either parasacral or GIN plane injection of 0.15 mL kg–1 dye solution. The parasacral region was dissected after injections to assess the staining of LST, cranial gluteal nerve, pararectal fossa and pelvic cavity. The stained LST were removed and processed for histological evaluation of intraneural injections. A one-sided z-test for non-inferiority (non-inferiority margin –14%) was used to statistically evaluate the success of the GIN plane versus the parasacral approach. Data were considered statistically significant when p < 0.05. The GIN plane and parasacral approach stained the LST in 100% and 93.3% of the injections, respectively. The success rate difference between treatments was 6.7% [95% confidence interval, –0.6 to 19.0%; p < 0.001 for non-inferiority]. The GIN plane and parasacral injections stained the LST for 32.7 ± 16.8 mm and 43.1 ± 24.3 mm, respectively (p = 0.18). No evidence of intraneural injection was found. The ultrasound-guided GIN plane technique resulted in nerve staining that was non-inferior to the parasacral technique and may be considered an alternative to the parasacral approach to block the LST in dogs. [ABSTRACT FROM AUTHOR]

Purpose: The knowledge management (KM) sharing process plays an essential role in manufacturing under Green Implementation Network (GIN). This study aims to analyze the KM process of adopting a GIN to determine the relative importance of technical risk minimization. The proposed conceptual model was tested by considering two interrelated concepts (GIN and KM process). Design/methodology/approach: Primary data from manufacturing companies in Henan province, China, were collected through 276 questionnaires. PLS-SEM and fuzzy set qualitative comparative analysis (fsQCA) were applied to investigate the configurational path of minimizing the technical risk in the manufacturing process. Findings: The findings showed that the GIN and KM processes minimize the technical risk. The fsQCA reported multiple configurational of GIN and KM processes validated toward technical risk reduction. The study's findings contribute to the existing body of knowledge on technical risk reduction in manufacturing concerns by investigating the complex intersection between GIN and KM process. Originality/value: This research adds to current GIN and KM literature by focusing on the green process using a resource-based view (RBV) and socio-technical theories. The current study provides practical and theoretical justification for explaining the relationship between GIN and KM processes. Moreover, this study adds to the literature by providing evidence that KM is an essential manufacturing industry enabler in minimizing technical risk. [ABSTRACT FROM AUTHOR]

Simple Summary: Gastrointestinal nematode (GIN) infections are serious parasitosis that cause disease in grazing livestock. The impact of these parasites is associated with important economic losses related to decreased production and the cost of anthelmintic treatments. Previous studies have reported that GIN infections, mainly those caused by Teladorsagia circumcincta, are associated with specific IgA levels. The goal of this study was to characterize IgA levels in naturally infected sheep belonging to Assaf, Castellana, and Churra breeds in different samples (blood, nasal secretions, and saliva). The association between IgA and fecal egg count, breed, and age was also studied. The infection risk according to age and/or breed was measured by a multilevel random intercept model. As a result, the model predicted that breed was not a factor influencing the risk of infection, while age was determinant. On the other hand, this study concludes that nasal secretions could be a useful sample to detect natural infections in young animals from any of the breeds included in this study. Further studies in sheep belonging to other breeds would be interesting in the future to verify this test. Specific IgA antibody has been shown to play an important role in resistance to gastrointestinal nematode (GIN) infections in sheep, particularly in Teladorsagia circumcincta parasitosis. In some breeds, negative associations have been shown between IgA levels and worm burden in experimentally infected sheep. In the present study, we have studied the relationship between IgA levels in naturally infected sheep (582 ewes in total; 193 younger than one year old and 389 older than one year old) and fecal egg count (FEC) in the Assaf, Castellana, and Churra breeds. ELISA assays were performed to measure IgA levels against the somatic antigen of T. circumcincta third larval stage (L3) and a 203-amino-acid fragment of the protein disulfide isomerase from the same GIN species. A multilevel random intercept model was developed to predict the infection risk according to age or breed. Spearman's correlation rank was used for statistical analysis. The prediction model showed that breed was not an influential factor in this study, although the Assaf breed could be considered slightly more susceptible than the others. In addition, age affected the infection risk, with the young ewes more susceptible to infection than the adult groups, except for the Castellana breed, whose risk of infection was similar at all ages. The most significant positive association was found between FEC and IgA measured in the nasal secretions of young ewes using both antigens (Rho = 0.5; p = 0.00); the correlation of FEC with IgA in serum was moderately significant (Rho = 0.306; p = 0.00). Comparing both antigens, the protein disulfide isomerase antigen was less reactive than the somatic antigen from L3. In conclusion, under natural conditions, specific IgA against GIN was positively associated with FEC in sheep, with nasal secretions from young animals being the sample where this association is stronger, which, therefore, could be used as a marker of infection in further studies. [ABSTRACT FROM AUTHOR]

The purpose of this study was to investigate the effect of short-term stimulation of classical music on the behavior of pullets and to explore whether classical music as an auditory enrichment factor reduces the fear level in pullets. One hundred and twenty 10-weeks'old Roman white pullets were randomly divided into two treatments of which one group was exposed to classic music (M), and another one was the control group (N). The music was played during 8:00–18:00 every day for 7 consecutive days. The behavior of the focal animals was observed from 11:00 to13:00 every day for 7 days. The results showed that during the observation period, the pullets in group M had more comforting (P <.05) and preening (P <.05), but less aggressive (P <.01) and feather-pecking (P <.01) behaviors than those in group N. No significant difference was found in other behaviors and the duration of tonic immobility between the two groups. Therefore, auditory enrichment as a means of environmental enrichment can increase the welfare level of pullets to a certain extent. [ABSTRACT FROM AUTHOR]

The empirical GIN (grouting intensity number) method is one of the most popular methods for structural stabilization and is increasingly used in many projects. The concept of this method is to limit the combination of pressure and volume injected to a specific grouting intensity number in order to control the energy induced in the rock fractures and to avoid heaving. In order to ensure the water tightness of the foundation of the Memve'ele hydroelectric dam, the treatment by the GIN method was implemented. The protocol implemented consisted to carry out a veil of injection drilling, consolidation, and control of effective treatment on each geotechnical hazard zone. Thus, 1240 injection boreholes were opened over a total length of 1600 m, i.e.: 613 pre-treatment boreholes and 627 consolidation boreholes. The results of the monitoring tests show that the 0.7 cement grouting treatment contributed to a reduction in crack permeability to less than 5 Lu (Lugeon units), a reduction of over 94%. This confinement of the rock was confirmed by geophysical imagery whose signature at the fractured interval varied after treatment. Geophysical and geohydrological characterization through permeability testing and electrical tomography revealed the existence of highly permeable discontinuity zones (over 90 Lu) below the bedrock surface, up to 15 m wide. Notwithstanding the volume of drilling carried out, the results obtained support the use of the GIN method in the stabilization of foundations of structures in the granite-gneissic basement zone. [ABSTRACT FROM AUTHOR]

Gin has become a very popular alcoholic drink, and is often used with various other mixers, often including fruit. The definition (Collins Paperback English Dictionary) reads as follows: "an alcoholic drink distilled from malted grain and flavoured juniper berries" (1994: 351). One of the most common drinks is gin mixed with tonic water, but there are also others mixers involved. Recently, in 2020, a competition was held in South Africa, with a panel of assessors tasting a wide variety of gins, and many who supplied their gin products with the brand names thereof achieved gold and silver medals for their entries of mainly craft gins. The purpose of this contribution is to analyze the various craft gin names in South Africa, as well as the names of the producing firms, distilleries, and estates. Within the context of onomastics, the focus is therefore on the actual name of the brand as it appears on the label, as well as on the location where it was produced, hence it is a combination of brand and location. [ABSTRACT FROM AUTHOR]