1. Design and application of nanoparticles as vaccine adjuvants against human corona virus infection
- Author
-
Yaling Wang, Chunying Chen, Lichun Mao, and Ziwei Chen
- Subjects
Calcium Phosphates ,pLN, proximal lymph nodes ,Human coronavirus ,medicine.medical_treatment ,CoV, coronavirus ,DENV, dengue virus ,MSNs, mesoporous silica nanoparticles ,MPLA, monophosphoryl lipid A ,medicine.disease_cause ,TNF-α, tumor necrosis factor-α ,Biochemistry ,ODN, oligodeoxynucleotide ,S protein, spike protein ,Th1, T helper type-1 ,RM, reverse microemulsion ,EV71, enterovirus 71 ,Coronavirus ,EDIII, envelope glycoprotein domain III ,ds, double-stranded ,Chemistry ,dLN, distal lymph nodes ,Viral Vaccine ,RBD, receptor-binding domain ,CaP, calcium phosphate ,HIV, human immunodeficiency virus ,APCs, antigen-presenting cells ,HEVA, hepatitis E vaccine ,Adjuvant ,2019-20 coronavirus outbreak ,PAPE, particulate alum via Pickering emulsion ,COVID-19 Vaccines ,ACE, angiotensin-converting enzyme ,CD, cluster of differentiation ,Article ,Virus ,Inorganic Chemistry ,Th2 Cells ,PEI, poly(ethyleneimine) ,Adjuvants, Immunologic ,Vaccine adjuvant ,Immunity ,medicine ,MHC, major histocompatibility complex ,Humans ,IFN, interferon ,MSRs, mesoporous silica rods ,TLR, toll-like receptor ,Th2, T helper type-2 ,FNC, flash nano-complexation ,Chitosan ,SARS-CoV-2 ,Viral Vaccines ,Vaccine adjuvants ,Th1 Cells ,PD, phosphodiester ,Ig, immunoglobulin ,Antibodies, Neutralizing ,Virology ,CpG-B, class B cytosine-guanine ,UV, ultraviolet ,IL, interleukin ,CpG, cytosine-guanine ,Ad5, adenoviral type 5 ,Nanoparticles ,RSV, respiratory syncytial virus ,Gold ,GNPs/AuNPs, gold nanoparticles ,Aluminum - Abstract
In recent years, some viruses have caused a grave crisis to global public health, especially the human coronavirus. A truly effective vaccine is therefore urgently needed. Vaccines should generally have two features: delivering antigens and modulating immunity. Adjuvants have an unshakable position in the battle against the virus. In addition to the perennial use of aluminium adjuvant, nanoparticles have become the developing adjuvant candidates due to their unique properties. Here we introduce several typical nanoparticles and their antivirus vaccine adjuvant applications. Finally, for the combating of the coronavirus, we propose several design points, hoping to provide ideas for the development of personalized vaccines and adjuvants and accelerate the clinical application of adjuvants., Graphical abstract Unlabelled Image
- Published
- 2021
- Full Text
- View/download PDF