Search

Your search keyword '"GROSSI, FRANCESCO"' showing total 1,076 results
Start Over Author "GROSSI, FRANCESCO"
1,076 results on '"GROSSI, FRANCESCO"'

1. Extracellular vesicles miR-574-5p and miR-181a-5p as prognostic markers in NSCLC patients treated with nivolumab

Author

Genova, Carlo, Marconi, Silvia, Chiorino, Giovanna, Guana, Francesca, Ostano, Paola, Santamaria, Sara, Rossi, Giovanni, Vanni, Irene, Longo, Luca, Tagliamento, Marco, Zullo, Lodovica, Dal Bello, Maria Giovanna, Dellepiane, Chiara, Alama, Angela, Rijavec, Erika, Ludovini, Vienna, Barletta, Giulia, Passiglia, Francesco, Metro, Giulio, Baglivo, Sara, Chiari, Rita, Rivoltini, Licia, Biello, Federica, Baraibar, Iosune, Gil-Bazo, Ignacio, Novello, Silvia, Grossi, Francesco, and Coco, Simona

Published
2024
Full Text
View/download PDF

2. Mobile Emergency, an Emergency Support System for Hospitals in Mobile Devices: Pilot Study

Author

Bellini, Pierfrancesco, Boncinelli, Sergio, Grossi, Francesco, Mangini, Marco, Nesi, Paolo, and Sequi, Leonardo

Subjects
Medicine, Computer applications to medicine. Medical informatics, R858-859.7
Abstract

BackgroundHospitals are vulnerable to natural disasters, man-made disasters, and mass causalities events. Within a short time, hospitals must provide care to large numbers of casualties in any damaged infrastructure, despite great personnel risk, inadequate communications, and limited resources. Communications are one of the most common challenges and drawbacks during in-hospital emergencies. Emergency difficulties in communicating with personnel and other agencies are mentioned in literature. At the moment of emergency inception and in the earliest emergency phases, the data regarding the true nature of the incidents are often inaccurate. The real needs and conditions are not yet clear, hospital personnel are neither efficiently coordinated nor informed on the real available resources. Information and communication technology solutions in health care turned out to have a great positive impact both on daily working practice and situations. ObjectiveThe objective of this paper was to find a solution that addresses the aspects of communicating among medical personnel, formalizing the modalities and protocols and the information to guide the medical personnel during emergency conditions with a support of a Central Station (command center) to cope with emergency management and best practice network to produce and distribute intelligent content made available in the mobile devices of the medical personnel. The aim was to reduce the time needed to react and to cope with emergency organization, while facilitating communications. MethodsThe solution has been realized by formalizing the scenarios, extracting, and identifying the requirements by using formal methods based on unified modeling language (UML). The system and was developed using mobile programming under iOS Apple and PHP: Hypertext Preprocessor My Structured Query Language (PHP MySQL). Formal questionnaires and time sheets were used for testing and validation, and a control group was used in order to estimate the reduction of time needed to cope with emergency cases. First, we have tested the usability and the functionalities of the solution proposed, then a real trial was performed to assess the reduction in communication time and the efficiency of the solution with respect to a case without Mobile Emergency tools. ResultsThe solution was based on the development of a mobile emergency application and corresponding server device to cope with emergencies and facilitate all the related activities and communications, such as marking the position, contacting people, and recovering the exits information. The solution has been successfully tested within the Careggi Hospital, the largest medical infrastructure in Florence and Tuscany area in Italy, thus demonstrating the validity of the identified modalities, procedures, and the reduction in the time needed to cope with the emergency conditions. The trial was not registered as the test was conducted in realistic but simulated emergency conditions. ConclusionsBy analyzing the requirements for developing a mobile app, and specifically the functionalities, codes, and design of the Mobile Emergency app, we have revealed the real advantages of using mobile emergency solutions compared to other more traditional solutions to effectively handle emergency situations in hospital settings.

Published
2013
Full Text
View/download PDF

3. Characteristics and outcomes of immunotherapy-related liver injury in patients with hepatocellular carcinoma versus other advanced solid tumours

Author

Celsa, Ciro, Cabibbo, Giuseppe, Fulgenzi, Claudia A.M., Scheiner, Bernhard, D’Alessio, Antonio, Manfredi, Giulia F., Nishida, Naoshi, Ang, Celina, Marron, Thomas U., Saeed, Anwaar, Wietharn, Brooke, Pinter, Matthias, Cheon, Jaekyung, Huang, Yi-Hsiang, Lee, Pei-Chang, Phen, Samuel, Gampa, Anuhya, Pillai, Anjana, Vivaldi, Caterina, Salani, Francesca, Masi, Gianluca, Roehlen, Natascha, Thimme, Robert, Vogel, Arndt, Schönlein, Martin, von Felden, Johann, Schulze, Kornelius, Wege, Henning, Galle, Peter R., Kudo, Masatoshi, Rimassa, Lorenza, Singal, Amit G., El Tomb, Paul, Ulahannan, Susanna, Parisi, Alessandro, Chon, Hong Jae, Hsu, Wei-Fan, Stefanini, Bernardo, Verzoni, Elena, Giusti, Raffaele, Veccia, Antonello, Catino, Annamaria, Aprile, Giuseppe, Guglielmini, Pamela Francesca, Di Napoli, Marilena, Ermacora, Paola, Antonuzzo, Lorenzo, Rossi, Ernesto, Verderame, Francesco, Zustovich, Fable, Ficorella, Corrado, Di Pietro, Francesca Romana, Battelli, Nicola, Negrini, Giorgia, Grossi, Francesco, Bordonaro, Roberto, Pipitone, Stefania, Banzi, Maria, Ricciardi, Serena, Laera, Letizia, Russo, Antonio, De Giorgi, Ugo, Cavanna, Luigi, Sorarù, Mariella, Montesarchio, Vincenzo, Bordi, Paola, Brunetti, Leonardo, Pinto, Carmine, Bersanelli, Melissa, Cammà, Calogero, Cortellini, Alessio, and Pinato, David J.

Published
2024
Full Text
View/download PDF

4. SAPPHIRE: phase III study of sitravatinib plus nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer

Author

Abdel-Karim, Isam, Abdelsalam, Mahmoud, Addeo, Alfredo, Aguado, Carlos, Alexander, Patrick, Alt, Jürgen, Azzi, Georges, Balaraman, Rama, Biesma, Bonne, Blackhall, Fiona, Bohnet, Sabine, Boleti, Ekaterini, Borghaei, Hossein, Bradbury, Penelope, Brighenti, Matteo, Campbell, Nicholas, Campbell, Toby, Canon, Jean-Luc, Cappuzzo, Federico, Costa, Enric Carcereny, Cavanna, Luigi, Cetnar, Jeremy, Chella, Antonio, Chouaid, Christos, Christoph, Daniel, Castán, Javier Cortés, Dakhil, Shaker, de Castro Carpeño, Francisco Javier, de Marinis, Filippo, Delmonte, Angelo, Demedts, Ingel, Demey, Wim, Dits, Joyce, del Pilar Diz Taín, Maria, Gómez, Manuel Dómine, Dorius, Timothy, Dumoulin, Daphne, Duruisseaux, Michaël, Eaton, Keith, González, Emilio Esteban, Evans, Devon, Faehling, Martin, Farrell, Nicholas, Feinstein, Trevor, Font, Enriqueta Felip, Garcia Campelo, Maria Rosario, Garon, Edward, Garrido López, María Pilar, Germonpré, Paul, Gersten, Todd, Cao, Maria Gonzalez, Gopaluni, Srivalli, Greillier, Laurent, Grossi, Francesco, Guisier, Florian, Gurubhagavatula, Sarada, Calderón, Vanesa Gutiérrez, Hakimian, David, Hall, Richard, Jr., Hao, Desirée, Harris, Ronald, Hashemi, Sayed, He, Kai, Hendriks, Lizza, Huang, Chao, Ibrahim, Emad, Jain, Sharad, Johnson, Melissa, Jones, Benjamin, Jones, Monte, Juan Vidal, Óscar José, Juergens, Rosalyn, Kaderbhai, Courèche, Kastelijn, Elisabeth A (Lisanne), Keresztes, Roger, Kio, Ebenezer, Kokowski, Konrad, Konduri, Kartik, Kulkarni, Swati, Kuon, Jonas, Kurkjian, Carla, Labbé, Catherine, Lerner, Rachel, Lim, Farah, Madroszyk-Flandin, Anne, Marathe, Omkar, Martincic, Danko, McClay, Edward, McIntyre, Kristi, Mekhail, Tarek, Misino, Andrea, Molinier, Olivier, Morabito, Alessandro, Morócz, Éva, Müller, Veronika, Nagy, Tünde, Nguyen, Anthony V., Nidhiry, Emmanuel, Okazaki, Ian, Ortega-Granados, Ana Laura, Ostoros, Gyula, Oubre, David, Owen, Scott, Pachipala, Krishna, Park, David, Patel, Pareshkumar, Percent, Ivor, Pérol, Maurice, Peters, Solange, Piet, Berber, Planchard, David, Polychronis, Andreas, Aix, Santiago Ponce, Pons-Tostivint, Elvire, Popat, Sanjaykumar, Pulla, Mariano Provencio, Quantin, Xavier, Quéré, Gilles, Rafique, Noman, Ramaekers, Ryan, Reck, Martin, Reiman, Anthony, Reinmuth, Niels, Reynolds, Craig, Rodríguez-Abreu, Delvys, Romano, Gianpiero, Roque, Tammy, Salzberg, Matthew, Sanborn, Rachel, Sandiego, Sergio, Schaefer, Eric, Schreeder, Marshall, Seetharamu, Nagashree, Seneviratne, Lasika, Shah, Purvi, Shunyakov, Leonid, Slater, Dennis, Parra, Hector Soto, Stigt, Johannes, Stilwill, Joseph, Su, Jingdong, Surmont, Veerle, Swink, Alicia, Szalai, Zsuzsanna, Talbot, Toby, Garcia, Alvaro Taus, Theelen, Willemijn, Thompson, Jonathan, Tiseo, Marcello, Uprety, Dipesh, Uyeki, James, van der Leest, Kornelius Cor, Van Ho, Anthony, van Putten, John, Estévez, Sergio Vázquez, Veatch, Andrea, Vergnenègre, Alain, Ward, Patrick, Weise, Amy, Weiss, Matthias, Whitehurst, Matthew, Zai, Silvia, Zalcman, Gérard, Zuniga, Richard, Borghaei, H., de Marinis, F., Dumoulin, D., Reynolds, C., Theelen, W.S.M.E., Percent, I., Gutierrez Calderon, V., Johnson, M.L., Madroszyk-Flandin, A., Garon, E.B., He, K., Planchard, D., Reck, M., Popat, S., Herbst, R.S., Leal, T.A., Shazer, R.L., Yan, X., Harrigan, R., and Peters, S.

Published
2024
Full Text
View/download PDF

5. Using peripheral immune-inflammatory blood markers in tumors treated with immune checkpoint inhibitors: An INVIDIa-2 study sub-analysis

Author

Anpalakhan, Shobana, Signori, Alessio, Cortellini, Alessio, Verzoni, Elena, Giusti, Raffaele, Aprile, Giuseppe, Ermacora, Paola, Catino, Annamaria, Pipitone, Stefania, Di Napoli, Marilena, Scotti, Vieri, Mazzoni, Francesca, Guglielmini, Pamela F., Veccia, Antonello, Maruzzo, Marco, Schinzari, Giovanni, Casadei, Chiara, Grossi, Francesco, Rizzo, Mimma, Montesarchio, Vincenzo, Verderame, Francesco, Mencoboni, Manlio, Zustovich, Fable, Fratino, Lucia, Accettura, Caterina, Cinieri, Saverio, Tondini, Carlo Alberto, Camerini, Andrea, Banzi, Maria Chiara, Sorarù, Mariella, Zucali, Paolo Andrea, Vignani, Francesca, Ricciardi, Serena, Russo, Antonio, Cosenza, Agnese, Di Maio, Massimo, De Giorgi, Ugo, Pignata, Sandro, Giannarelli, Diana, Pinto, Carmine, Buti, Sebastiano, Fornarini, Giuseppe, Rebuzzi, Sara Elena, Rescigno, Pasquale, Addeo, Alfredo, Banna, Giuseppe L., and Bersanelli, Melissa

Published
2023
Full Text
View/download PDF

7. Impact of influenza vaccination on survival of patients with advanced cancer receiving immune checkpoint inhibitors (INVIDIa-2): final results of the multicentre, prospective, observational study

Author

Bersanelli, Melissa, Verzoni, Elena, Cortellini, Alessio, Giusti, Raffaele, Calvetti, Lorenzo, Ermacora, Paola, Di Napoli, Marilena, Catino, Annamaria, Guadalupi, Valentina, Guaitoli, Giorgia, Scotti, Vieri, Mazzoni, Francesca, Veccia, Antonello, Guglielmini, Pamela Francesca, Perrone, Fabiana, Maruzzo, Marco, Rossi, Ernesto, Casadei, Chiara, Montesarchio, Vincenzo, Grossi, Francesco, Rizzo, Mimma, Travagliato Liboria, Maria Grazia, Mencoboni, Manlio, Zustovich, Fable, Fratino, Lucia, Accettura, Caterina, Cinieri, Saverio, Camerini, Andrea, Sorarù, Mariella, Zucali, Paolo Andrea, Ricciardi, Serena, Russo, Antonio, Negrini, Giorgia, Banzi, Maria Chiara, Lacidogna, Gaetano, Fornarini, Giuseppe, Laera, Letizia, Mucciarini, Claudia, Santoni, Matteo, Mosillo, Claudia, Bonetti, Andrea, Longo, Lucia, Sartori, Donata, Baldini, Editta, Guida, Michele, Iannopollo, Mauro, Bordonaro, Roberto, Morelli, Maria Francesca, Tagliaferri, Pierosandro, Spada, Massimiliano, Ceribelli, Anna, Silva, Rosa Rita, Nolè, Franco, Beretta, Giordano, Giovanis, Petros, Santini, Daniele, Luzi Fedeli, Stefano, Nanni, Oriana, Maiello, Evaristo, Labianca, Roberto, Pinto, Carmine, Clemente, Alberto, Tognetto, Michele, De Giorgi, Ugo, Pignata, Sandro, Di Maio, Massimo, Buti, Sebastiano, and Giannarelli, Diana

Published
2023
Full Text
View/download PDF

8. Clinical outcomes of NSCLC patients experiencing early immune-related adverse events to PD-1/PD-L1 checkpoint inhibitors leading to treatment discontinuation

Author

Russano, Marco, Cortellini, Alessio, Giusti, Raffaele, Russo, Alessandro, Zoratto, Federica, Rastelli, Francesca, Gelibter, Alain, Chiari, Rita, Nigro, Olga, De Tursi, Michele, Bracarda, Sergio, Gori, Stefania, Grossi, Francesco, Bersanelli, Melissa, Calvetti, Lorenzo, Di Noia, Vincenzo, Scartozzi, Mario, Di Maio, Massimo, Bossi, Paolo, Falcone, Alfredo, Citarella, Fabrizio, Pantano, Francesco, Ficorella, Corrado, Filetti, Marco, Adamo, Vincenzo, Veltri, Enzo, Pergolesi, Federica, Occhipinti, Mario Alberto, Nicolardi, Linda, Tuzi, Alessandro, Di Marino, Pietro, Macrini, Serena, Inno, Alessandro, Ghidini, Michele, Buti, Sebastiano, Aprile, Giuseppe, Lai, Eleonora, Audisio, Marco, Intagliata, Salvatore, Marconcini, Riccardo, Brocco, Davide, Porzio, Giampiero, Piras, Marta, Rijavec, Erika, Simionato, Francesca, Natoli, Clara, Tiseo, Marcello, Vincenzi, Bruno, Tonini, Giuseppe, and Santini, Daniele

Published
2022
Full Text
View/download PDF

9. High familial burden of cancer correlates with improved outcome from immunotherapy in patients with NSCLC independent of somatic DNA damage response gene status

Author

Cortellini, Alessio, Giusti, Raffaele, Filetti, Marco, Citarella, Fabrizio, Adamo, Vincenzo, Santini, Daniele, Buti, Sebastiano, Nigro, Olga, Cantini, Luca, Di Maio, Massimo, Aerts, Joachim G. J. V., Bria, Emilio, Bertolini, Federica, Ferrara, Miriam Grazia, Ghidini, Michele, Grossi, Francesco, Guida, Annalisa, Berardi, Rossana, Morabito, Alessandro, Genova, Carlo, Mazzoni, Francesca, Antonuzzo, Lorenzo, Gelibter, Alain, Marchetti, Paolo, Chiari, Rita, Macerelli, Marianna, Rastelli, Francesca, Della Gravara, Luigi, Gori, Stefania, Tuzi, Alessandro, De Tursi, Michele, Di Marino, Pietro, Mansueto, Giovanni, Pecci, Federica, Zoratto, Federica, Ricciardi, Serena, Migliorino, Maria Rita, Passiglia, Francesco, Metro, Giulio, Spinelli, Gian Paolo, Banna, Giuseppe L., Friedlaender, Alex, Addeo, Alfredo, Ficorella, Corrado, Porzio, Giampiero, Tiseo, Marcello, Russano, Marco, Russo, Alessandro, and Pinato, David James

Published
2022
Full Text
View/download PDF

11. First-line nivolumab plus ipilimumab versus chemotherapy for the treatment of unresectable malignant pleural mesothelioma: patient-reported outcomes in CheckMate 743

Author

Scherpereel, Arnaud, Antonia, Scott, Bautista, Yolanda, Grossi, Francesco, Kowalski, Dariusz, Zalcman, Gérard, Nowak, Anna K., Fujimoto, Nobukazu, Peters, Solange, Tsao, Anne S., Mansfield, Aaron S., Popat, Sanjay, Sun, Xiaowu, Lawrance, Rachael, Zhang, Xiaoqing, Daumont, Melinda J., Bennett, Bryan, McKenna, Mike, and Baas, Paul

Published
2022
Full Text
View/download PDF

12. Gemcitabine with or without ramucirumab as second-line treatment for malignant pleural mesothelioma (RAMES): a randomised, double-blind, placebo-controlled, phase 2 trial

Author

Pinto, Carmine, Zucali, Paolo Andrea, Pagano, Maria, Grosso, Federica, Pasello, Giulia, Garassino, Marina Chiara, Tiseo, Marcello, Soto Parra, Hector, Grossi, Francesco, Cappuzzo, Federico, de Marinis, Filippo, Pedrazzoli, Paolo, Bonomi, Maria, Gianoncelli, Letizia, Perrino, Matteo, Santoro, Armando, Zanelli, Francesca, Bonelli, Candida, Maconi, Antonio, Frega, Stefano, Gervasi, Erika, Boni, Luca, and Ceresoli, Giovanni Luca

Published
2021
Full Text
View/download PDF

14. Radiation-Related Deregulation of TUBB3 and BRCA1/2 and Risk of Secondary Lung Cancer in Women With Breast Cancer

Author

Coco, Simona, Boccardo, Simona, Mora, Marco, Fontana, Vincenzo, Vanni, Irene, Genova, Carlo, Alama, Angela, Salvi, Sandra, Dal Bello, Maria Giovanna, Bonfiglio, Silvia, Rijavec, Erika, Sini, Claudio, Barletta, Giulia, Biello, Federica, Carli, Franca, Cavalieri, Zita, Burrafato, Giovanni, Longo, Luca, Ballestrero, Alberto, and Grossi, Francesco

Published
2021
Full Text
View/download PDF

17. Multidisciplinary management of immunotherapy‐related adverse events in solid tumors: An inter‐institutional and telemedicine‐based working team.

Author

Iaculli, Alessandro, Ghidini, Michele, Locati, Francesco, Chiappa, Laura, Nastasi, Giuseppe, Fasola, Gianpiero, Grossi, Francesco, Garrone, Ornella, and Tozzi, Valeria D.

Subjects
ADVERSE health care events, DRUG side effects, TEAMS in the workplace, IMMUNE checkpoint inhibitors, MEDICAL specialties & specialists
Abstract

Background: Although immune checkpoint inhibitors (ICIs) show a more favorable toxicity profile than classical cytotoxic drugs, their mechanism of action is responsible for peculiar new toxicities. There is an urgent need for a multidisciplinary approach to advice on how to manage organ‐specific toxicities. Methods: Our project aims to integrate the practices of two different hospitals into a single Italian regional collaborative model to treat immune‐related adverse events (irAEs). The team structure is a multi‐professional and multidisciplinary cooperative network that consists of different medical specialists. The team referrer is the medical oncologist and an existing telematic platform is used for specialists' cooperation. The leading oncologist first evaluates patients' clinical condition, therefore team intervention and teleconsultation are planned to activate proper management. After a first phase structured for general setting, outcomes analysis, data collection, and identification of critical issues, it is planned to define appropriate key performance indicators (KPIs) in quality, structure, process, and outcome settings. Therefore, a second phase would serve to implement KPIs. In the third phase, the proposal for the enlargement of the network with the extension to more centers in the context of the Regional Health Service will be performed. Discussion: The multidisciplinary management of irAEs based on telemedicine fits into the debate on the renewal of healthcare systems and the push for change toward multidisciplinary with the rising use of telemedicine. To our knowledge, this is the first project reporting a multi‐institutional experience for change of service in irAEs management. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

18. Immune-related Adverse Events of Pembrolizumab in a Large Real-world Cohort of Patients With NSCLC With a PD-L1 Expression ≥ 50% and Their Relationship With Clinical Outcomes

Author

Cortellini, Alessio, Friedlaender, Alex, Banna, Giuseppe L., Porzio, Giampiero, Bersanelli, Melissa, Cappuzzo, Federico, Aerts, Joachim G.J.V., Giusti, Raffaele, Bria, Emilio, Cortinovis, Diego, Grossi, Francesco, Migliorino, Maria R., Galetta, Domenico, Passiglia, Francesco, Berardi, Rossana, Mazzoni, Francesca, Di Noia, Vincenzo, Signorelli, Diego, Tuzi, Alessandro, Gelibter, Alain, Marchetti, Paolo, Macerelli, Marianna, Rastelli, Francesca, Chiari, Rita, Rocco, Danilo, Inno, Alessandro, Di Marino, Pietro, Mansueto, Giovanni, Zoratto, Federica, Santoni, Matteo, Tudini, Marianna, Ghidini, Michele, Filetti, Marco, Catino, Annamaria, Pizzutilo, Pamela, Sala, Luca, Occhipinti, Mario Alberto, Citarella, Fabrizio, Russano, Marco, Torniai, Mariangela, Cantini, Luca, Follador, Alessandro, Sforza, Vincenzo, Nigro, Olga, Ferrara, Miriam G., D’Argento, Ettore, Leonetti, Alessandro, Pettoruti, Linda, Antonuzzo, Lorenzo, Scodes, Simona, Landi, Lorenza, Guaitoli, Giorgia, Baldessari, Cinzia, Bertolini, Federica, Della Gravara, Luigi, Dal Bello, Maria Giovanna, Belderbos, Robert A., De Filippis, Marco, Cecchi, Cristina, Ricciardi, Serena, Donisi, Clelia, De Toma, Alessandro, Proto, Claudia, Addeo, Alfredo, Cantale, Ornella, Ricciuti, Biagio, Genova, Carlo, Morabito, Alessandro, Santini, Daniele, Ficorella, Corrado, and Cannita, Katia

Published
2020
Full Text
View/download PDF

20. COVID-19 in patients with thoracic malignancies (TERAVOLT): first results of an international, registry-based, cohort study

Author

Garassino, Marina Chiara, Whisenant, Jennifer G, Huang, Li-Ching, Trama, Annalisa, Torri, Valter, Agustoni, Francesco, Baena, Javier, Banna, Giuseppe, Berardi, Rossana, Bettini, Anna Cecilia, Bria, Emilio, Brighenti, Matteo, Cadranel, Jacques, De Toma, Alessandro, Chini, Claudio, Cortellini, Alessio, Felip, Enriqueta, Finocchiaro, Giovanna, Garrido, Pilar, Genova, Carlo, Giusti, Raffaele, Gregorc, Vanesa, Grossi, Francesco, Grosso, Federica, Intagliata, Salvatore, La Verde, Nicla, Liu, Stephen V, Mazieres, Julien, Mercadante, Edoardo, Michielin, Olivier, Minuti, Gabriele, Moro-Sibilot, Denis, Pasello, Giulia, Passaro, Antonio, Scotti, Vieri, Solli, Piergiorgio, Stroppa, Elisa, Tiseo, Marcello, Viscardi, Giuseppe, Voltolini, Luca, Wu, Yi-Long, Zai, Silvia, Pancaldi, Vera, Dingemans, Anne-Marie, Van Meerbeeck, Jan, Barlesi, Fabrice, Wakelee, Heather, Peters, Solange, and Horn, Leora

Published
2020
Full Text
View/download PDF

23. PD-1/PD-L1 checkpoint inhibitors during late stages of life: an ad-hoc analysis from a large multicenter cohort

Author

Santini, Daniele, Zeppola, Tea, Russano, Marco, Citarella, Fabrizio, Anesi, Cecilia, Buti, Sebastiano, Tucci, Marco, Russo, Alessandro, Sergi, Maria Chiara, Adamo, Vincenzo, Stucci, Luigia S., Bersanelli, Melissa, Mazzaschi, Giulia, Spagnolo, Francesco, Rastelli, Francesca, Giorgi, Francesca Chiara, Giusti, Raffaele, Filetti, Marco, Marchetti, Paolo, Botticelli, Andrea, Gelibter, Alain, Siringo, Marco, Ferrari, Marco, Marconcini, Riccardo, Vitale, Maria Giuseppa, Nicolardi, Linda, Chiari, Rita, Ghidini, Michele, Nigro, Olga, Grossi, Francesco, De Tursi, Michele, Di Marino, Pietro, Pala, Laura, Queirolo, Paola, Bracarda, Sergio, Macrini, Serena, Gori, Stefania, Inno, Alessandro, Zoratto, Federica, Tanda, Enrica T., Mallardo, Domenico, Vitale, Maria Grazia, Talbot, Thomas, Ascierto, Paolo A., Pinato, David J., Ficorella, Corrado, Porzio, Giampiero, and Cortellini, Alessio

Published
2021
Full Text
View/download PDF

24. Clinicopathologic correlates of first-line pembrolizumab effectiveness in patients with advanced NSCLC and a PD-L1 expression of ≥ 50%

Author

Cortellini, Alessio, Tiseo, Marcello, Banna, Giuseppe L., Cappuzzo, Federico, Aerts, Joachim G. J. V., Barbieri, Fausto, Giusti, Raffaele, Bria, Emilio, Cortinovis, Diego, Grossi, Francesco, Migliorino, Maria R., Galetta, Domenico, Passiglia, Francesco, Santini, Daniele, Berardi, Rossana, Morabito, Alessandro, Genova, Carlo, Mazzoni, Francesca, Di Noia, Vincenzo, Signorelli, Diego, Tuzi, Alessandro, Gelibter, Alain, Marchetti, Paolo, Macerelli, Marianna, Rastelli, Francesca, Chiari, Rita, Rocco, Danilo, Gori, Stefania, De Tursi, Michele, Mansueto, Giovanni, Zoratto, Federica, Santoni, Matteo, Tudini, Marianna, Rijavec, Erika, Filetti, Marco, Catino, Annamaria, Pizzutilo, Pamela, Sala, Luca, Citarella, Fabrizio, Marco, Russano, Torniai, Mariangela, Cantini, Luca, Targato, Giada, Sforza, Vincenzo, Nigro, Olga, Ferrara, Miriam G., D’Argento, Ettore, Buti, Sebastiano, Bordi, Paola, Antonuzzo, Lorenzo, Scodes, Simona, Landi, Lorenza, Guaitoli, Giorgia, Baldessari, Cinzia, Della Gravara, Luigi, Dal Bello, Maria Giovanna, Belderbos, Robert A., Bironzo, Paolo, Carnio, Simona, Ricciardi, Serena, Grieco, Alessio, De Toma, Alessandro, Proto, Claudia, Friedlaender, Alex, Cantale, Ornella, Ricciuti, Biagio, Addeo, Alfredo, Metro, Giulio, Ficorella, Corrado, and Porzio, Giampiero

Published
2020
Full Text
View/download PDF

26. SAPPHIRE: phase III study of sitravatinib plus nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer

Author

Borghaei, H., primary, de Marinis, F., additional, Dumoulin, D., additional, Reynolds, C., additional, Theelen, W.S.M.E., additional, Percent, I., additional, Gutierrez Calderon, V., additional, Johnson, M.L., additional, Madroszyk-Flandin, A., additional, Garon, E.B., additional, He, K., additional, Planchard, D., additional, Reck, M., additional, Popat, S., additional, Herbst, R.S., additional, Leal, T.A., additional, Shazer, R.L., additional, Yan, X., additional, Harrigan, R., additional, Peters, S., additional, Abdel-Karim, Isam, additional, Abdelsalam, Mahmoud, additional, Addeo, Alfredo, additional, Aguado, Carlos, additional, Alexander, Patrick, additional, Alt, Jürgen, additional, Azzi, Georges, additional, Balaraman, Rama, additional, Biesma, Bonne, additional, Blackhall, Fiona, additional, Bohnet, Sabine, additional, Boleti, Ekaterini, additional, Borghaei, Hossein, additional, Bradbury, Penelope, additional, Brighenti, Matteo, additional, Campbell, Nicholas, additional, Campbell, Toby, additional, Canon, Jean-Luc, additional, Cappuzzo, Federico, additional, Costa, Enric Carcereny, additional, Cavanna, Luigi, additional, Cetnar, Jeremy, additional, Chella, Antonio, additional, Chouaid, Christos, additional, Christoph, Daniel, additional, Castán, Javier Cortés, additional, Dakhil, Shaker, additional, de Castro Carpeño, Francisco Javier, additional, de Marinis, Filippo, additional, Delmonte, Angelo, additional, Demedts, Ingel, additional, Demey, Wim, additional, Dits, Joyce, additional, del Pilar Diz Taín, Maria, additional, Gómez, Manuel Dómine, additional, Dorius, Timothy, additional, Dumoulin, Daphne, additional, Duruisseaux, Michaël, additional, Eaton, Keith, additional, González, Emilio Esteban, additional, Evans, Devon, additional, Faehling, Martin, additional, Farrell, Nicholas, additional, Feinstein, Trevor, additional, Font, Enriqueta Felip, additional, Garcia Campelo, Maria Rosario, additional, Garon, Edward, additional, Garrido López, María Pilar, additional, Germonpré, Paul, additional, Gersten, Todd, additional, Cao, Maria Gonzalez, additional, Gopaluni, Srivalli, additional, Greillier, Laurent, additional, Grossi, Francesco, additional, Guisier, Florian, additional, Gurubhagavatula, Sarada, additional, Calderón, Vanesa Gutiérrez, additional, Hakimian, David, additional, Hall, Richard, additional, Hao, Desirée, additional, Harris, Ronald, additional, Hashemi, Sayed, additional, He, Kai, additional, Hendriks, Lizza, additional, Huang, Chao, additional, Ibrahim, Emad, additional, Jain, Sharad, additional, Johnson, Melissa, additional, Jones, Benjamin, additional, Jones, Monte, additional, Juan Vidal, Óscar José, additional, Juergens, Rosalyn, additional, Kaderbhai, Courèche, additional, Kastelijn, Elisabeth A (Lisanne), additional, Keresztes, Roger, additional, Kio, Ebenezer, additional, Kokowski, Konrad, additional, Konduri, Kartik, additional, Kulkarni, Swati, additional, Kuon, Jonas, additional, Kurkjian, Carla, additional, Labbé, Catherine, additional, Lerner, Rachel, additional, Lim, Farah, additional, Madroszyk-Flandin, Anne, additional, Marathe, Omkar, additional, Martincic, Danko, additional, McClay, Edward, additional, McIntyre, Kristi, additional, Mekhail, Tarek, additional, Misino, Andrea, additional, Molinier, Olivier, additional, Morabito, Alessandro, additional, Morócz, Éva, additional, Müller, Veronika, additional, Nagy, Tünde, additional, Nguyen, Anthony V., additional, Nidhiry, Emmanuel, additional, Okazaki, Ian, additional, Ortega-Granados, Ana Laura, additional, Ostoros, Gyula, additional, Oubre, David, additional, Owen, Scott, additional, Pachipala, Krishna, additional, Park, David, additional, Patel, Pareshkumar, additional, Percent, Ivor, additional, Pérol, Maurice, additional, Peters, Solange, additional, Piet, Berber, additional, Planchard, David, additional, Polychronis, Andreas, additional, Aix, Santiago Ponce, additional, Pons-Tostivint, Elvire, additional, Popat, Sanjaykumar, additional, Pulla, Mariano Provencio, additional, Quantin, Xavier, additional, Quéré, Gilles, additional, Rafique, Noman, additional, Ramaekers, Ryan, additional, Reck, Martin, additional, Reiman, Anthony, additional, Reinmuth, Niels, additional, Reynolds, Craig, additional, Rodríguez-Abreu, Delvys, additional, Romano, Gianpiero, additional, Roque, Tammy, additional, Salzberg, Matthew, additional, Sanborn, Rachel, additional, Sandiego, Sergio, additional, Schaefer, Eric, additional, Schreeder, Marshall, additional, Seetharamu, Nagashree, additional, Seneviratne, Lasika, additional, Shah, Purvi, additional, Shunyakov, Leonid, additional, Slater, Dennis, additional, Parra, Hector Soto, additional, Stigt, Johannes, additional, Stilwill, Joseph, additional, Su, Jingdong, additional, Surmont, Veerle, additional, Swink, Alicia, additional, Szalai, Zsuzsanna, additional, Talbot, Toby, additional, Garcia, Alvaro Taus, additional, Theelen, Willemijn, additional, Thompson, Jonathan, additional, Tiseo, Marcello, additional, Uprety, Dipesh, additional, Uyeki, James, additional, van der Leest, Kornelius Cor, additional, Van Ho, Anthony, additional, van Putten, John, additional, Estévez, Sergio Vázquez, additional, Veatch, Andrea, additional, Vergnenègre, Alain, additional, Ward, Patrick, additional, Weise, Amy, additional, Weiss, Matthias, additional, Whitehurst, Matthew, additional, Zai, Silvia, additional, Zalcman, Gérard, additional, and Zuniga, Richard, additional

Published
2023
Full Text
View/download PDF

27. Use of nivolumab in elderly patients with advanced squamous non–small-cell lung cancer: results from the Italian cohort of an expanded access programme

Author

Grossi, Francesco, Crinò, Lucio, Logroscino, Antonio, Canova, Stefania, Delmonte, Angelo, Melotti, Barbara, Proto, Claudia, Gelibter, Alain, Cappuzzo, Federico, Turci, Daniele, Gamucci, Teresa, Antonelli, Paola, Marchetti, Paolo, Santoro, Armando, Giusti, Sabrina, Di Costanzo, Francesco, Giustini, Lucio, Del Conte, Alessandro, Livi, Lorenzo, Giannarelli, Diana, and de Marinis, Filippo

Published
2018
Full Text
View/download PDF

28. 30 Immunotherapy in advanced NSCLC—from the ‘tsunami’ of therapeutic knowledge to a clinical practice algorithm: results from an international expert panel meeting of the Italian Association of Thoracic Oncology (AIOT)

Author

de Marinis, Filippo, Ciardiello, Fortunato, Baas, Paul, Crinò, Lucio, Giaccone, Giuseppe, Grossi, Francesco, Hellmann, Matthew D., Mok, Tony S.K., Lena, Hervè, Paz-Ares, Luis, Rodriguez-Abreu, Delvys, Von Pavel, Joachim, and Gridelli, Cesare

Published
2018
Full Text
View/download PDF

29. Baseline serum levels of osteopontin predict clinical response to treatment with nivolumab in patients with non-small cell lung cancer

Author

Carbone, Federico, Grossi, Francesco, Bonaventura, Aldo, Vecchié, Alessandra, Minetti, Silvia, Bardi, Nicholas, Elia, Edoardo, Ansaldo, Anna Maria, Ferrara, Daniele, Rijavec, Erika, Dal Bello, Maria Giovanna, Biello, Federica, Rossi, Giovanni, Tagliamento, Marco, Alama, Angela, Coco, Simona, Spallarossa, Paolo, Dallegri, Franco, Genova, Carlo, and Montecucco, Fabrizio

Published
2019
Full Text
View/download PDF

30. Serum PCSK9 levels at the second nivolumab cycle predict overall survival in elderly patients with NSCLC: a pilot study

Author

Bonaventura, Aldo, Grossi, Francesco, Carbone, Federico, Vecchié, Alessandra, Minetti, Silvia, Bardi, Nicholas, Elia, Edoardo, Ansaldo, Anna Maria, Ferrara, Daniele, Rijavec, Erika, Dal Bello, Maria Giovanna, Rossi, Giovanni, Biello, Federica, Tagliamento, Marco, Alama, Angela, Coco, Simona, Spallarossa, Paolo, Dallegri, Franco, Genova, Carlo, and Montecucco, Fabrizio

Published
2019
Full Text
View/download PDF

33. Data from Type 2 Diabetes Mellitus and Efficacy Outcomes from Immune Checkpoint Blockade in Patients with Cancer

Author

Cortellini, Alessio, primary, D'Alessio, Antonio, primary, Cleary, Siobhan, primary, Buti, Sebastiano, primary, Bersanelli, Melissa, primary, Bordi, Paola, primary, Tonini, Giuseppe, primary, Vincenzi, Bruno, primary, Tucci, Marco, primary, Russo, Alessandro, primary, Pantano, Francesco, primary, Russano, Marco, primary, Stucci, Luigia Stefania, primary, Sergi, Maria Chiara, primary, Falconi, Martina, primary, Zarzana, Maria Antonietta, primary, Santini, Daniele, primary, Spagnolo, Francesco, primary, Tanda, Enrica T., primary, Rastelli, Francesca, primary, Giorgi, Francesca Chiara, primary, Pergolesi, Federica, primary, Giusti, Raffaele, primary, Filetti, Marco, primary, Lo Bianco, Francesca, primary, Marchetti, Paolo, primary, Botticelli, Andrea, primary, Gelibter, Alain, primary, Siringo, Marco, primary, Ferrari, Marco, primary, Marconcini, Riccardo, primary, Vitale, Maria Giuseppa, primary, Nicolardi, Linda, primary, Chiari, Rita, primary, Ghidini, Michele, primary, Nigro, Olga, primary, Grossi, Francesco, primary, De Tursi, Michele, primary, Di Marino, Pietro, primary, Queirolo, Paola, primary, Bracarda, Sergio, primary, Macrini, Serena, primary, Inno, Alessandro, primary, Zoratto, Federica, primary, Veltri, Enzo, primary, Spoto, Chiara, primary, Vitale, Maria Grazia, primary, Cannita, Katia, primary, Gennari, Alessandra, primary, Morganstein, Daniel L., primary, Mallardo, Domenico, primary, Nibid, Lorenzo, primary, Sabarese, Giovanna, primary, Brunetti, Leonardo, primary, Perrone, Giuseppe, primary, Ascierto, Paolo A., primary, Ficorella, Corrado, primary, and Pinato, David J., primary

Published
2023
Full Text
View/download PDF

34. Supplementary Table S8 from Type 2 Diabetes Mellitus and Efficacy Outcomes from Immune Checkpoint Blockade in Patients with Cancer

Author

Cortellini, Alessio, primary, D'Alessio, Antonio, primary, Cleary, Siobhan, primary, Buti, Sebastiano, primary, Bersanelli, Melissa, primary, Bordi, Paola, primary, Tonini, Giuseppe, primary, Vincenzi, Bruno, primary, Tucci, Marco, primary, Russo, Alessandro, primary, Pantano, Francesco, primary, Russano, Marco, primary, Stucci, Luigia Stefania, primary, Sergi, Maria Chiara, primary, Falconi, Martina, primary, Zarzana, Maria Antonietta, primary, Santini, Daniele, primary, Spagnolo, Francesco, primary, Tanda, Enrica T., primary, Rastelli, Francesca, primary, Giorgi, Francesca Chiara, primary, Pergolesi, Federica, primary, Giusti, Raffaele, primary, Filetti, Marco, primary, Lo Bianco, Francesca, primary, Marchetti, Paolo, primary, Botticelli, Andrea, primary, Gelibter, Alain, primary, Siringo, Marco, primary, Ferrari, Marco, primary, Marconcini, Riccardo, primary, Vitale, Maria Giuseppa, primary, Nicolardi, Linda, primary, Chiari, Rita, primary, Ghidini, Michele, primary, Nigro, Olga, primary, Grossi, Francesco, primary, De Tursi, Michele, primary, Di Marino, Pietro, primary, Queirolo, Paola, primary, Bracarda, Sergio, primary, Macrini, Serena, primary, Inno, Alessandro, primary, Zoratto, Federica, primary, Veltri, Enzo, primary, Spoto, Chiara, primary, Vitale, Maria Grazia, primary, Cannita, Katia, primary, Gennari, Alessandra, primary, Morganstein, Daniel L., primary, Mallardo, Domenico, primary, Nibid, Lorenzo, primary, Sabarese, Giovanna, primary, Brunetti, Leonardo, primary, Perrone, Giuseppe, primary, Ascierto, Paolo A., primary, Ficorella, Corrado, primary, and Pinato, David J., primary

Published
2023
Full Text
View/download PDF

35. Supplementary Figure S8 from Type 2 Diabetes Mellitus and Efficacy Outcomes from Immune Checkpoint Blockade in Patients with Cancer

Author

Cortellini, Alessio, primary, D'Alessio, Antonio, primary, Cleary, Siobhan, primary, Buti, Sebastiano, primary, Bersanelli, Melissa, primary, Bordi, Paola, primary, Tonini, Giuseppe, primary, Vincenzi, Bruno, primary, Tucci, Marco, primary, Russo, Alessandro, primary, Pantano, Francesco, primary, Russano, Marco, primary, Stucci, Luigia Stefania, primary, Sergi, Maria Chiara, primary, Falconi, Martina, primary, Zarzana, Maria Antonietta, primary, Santini, Daniele, primary, Spagnolo, Francesco, primary, Tanda, Enrica T., primary, Rastelli, Francesca, primary, Giorgi, Francesca Chiara, primary, Pergolesi, Federica, primary, Giusti, Raffaele, primary, Filetti, Marco, primary, Lo Bianco, Francesca, primary, Marchetti, Paolo, primary, Botticelli, Andrea, primary, Gelibter, Alain, primary, Siringo, Marco, primary, Ferrari, Marco, primary, Marconcini, Riccardo, primary, Vitale, Maria Giuseppa, primary, Nicolardi, Linda, primary, Chiari, Rita, primary, Ghidini, Michele, primary, Nigro, Olga, primary, Grossi, Francesco, primary, De Tursi, Michele, primary, Di Marino, Pietro, primary, Queirolo, Paola, primary, Bracarda, Sergio, primary, Macrini, Serena, primary, Inno, Alessandro, primary, Zoratto, Federica, primary, Veltri, Enzo, primary, Spoto, Chiara, primary, Vitale, Maria Grazia, primary, Cannita, Katia, primary, Gennari, Alessandra, primary, Morganstein, Daniel L., primary, Mallardo, Domenico, primary, Nibid, Lorenzo, primary, Sabarese, Giovanna, primary, Brunetti, Leonardo, primary, Perrone, Giuseppe, primary, Ascierto, Paolo A., primary, Ficorella, Corrado, primary, and Pinato, David J., primary

Published
2023
Full Text
View/download PDF

38. Type 2 diabetes mellitus and efficacy outcomes from imune checkpoint blockade in patients with cancer

Author

Cortellini, Alessio, primary, D'Alessio, Antonio, additional, Cleary, Siobhan, additional, Buti, Sebastiano, additional, Bersanelli, Melissa, additional, Bordi, Paola, additional, Tonini, Giuseppe, additional, Vincenzi, Bruno, additional, Tucci, Marco, additional, Russo, Alessandro, additional, Pantano, Francesco, additional, Russano, Marco, additional, Stucci, Luigia Stefania, additional, Sergi, Maria Chiara, additional, Falconi, Martina, additional, Zarzana, Maria Antonietta., additional, Santini, Daniele, additional, Spagnolo, Francesco, additional, Tanda, Enrica T., additional, Rastelli, Francesca, additional, Giorgi, Francesca Chiara., additional, Pergolesi, Federica, additional, Giusti, Raffaele, additional, Filetti, Marco, additional, Lo Bianco, Francesca, additional, Marchetti, Paolo, additional, Botticelli, Andrea, additional, Gelibter, Alain, additional, Siringo, Marco, additional, Ferrari, Marco, additional, Marconcini, Riccardo, additional, Vitale, Maria Giuseppa., additional, Nicolardi, Linda, additional, Chiari, Rita, additional, Ghidini, Michele, additional, Nigro, Olga, additional, Grossi, Francesco, additional, De Tursi, Michele, additional, Di Marino, Pietro, additional, Queirolo, Paola, additional, Bracarda, Sergio, additional, Macrini, Serena, additional, Inno, Alessandro, additional, Zoratto, Federica, additional, Veltri, Enzo, additional, Spoto, Chiara, additional, Vitale, Maria Grazia., additional, Cannita, Katia, additional, Gennari, Alessandra, additional, Morganstein, Daniel L., additional, Mallardo, Domenico, additional, Nibid, Lorenzo, additional, Sabarese, Giovanna, additional, Brunetti, Leonardo, additional, Perrone, Giuseppe, additional, Ascierto, Paolo A., additional, Ficorella, Corrado, additional, and Pinato, David J., additional

Published
2023
Full Text
View/download PDF

39. Safety of Extended interval Dosing Immune Checkpoint Inhibitors: a multicentre cohort study

Author

Cantini, Luca, primary, Paoloni, Francesco, additional, Pecci, Federica, additional, Spagnolo, Francesco, additional, Genova, Carlo, additional, Tanda, Enrica Teresa, additional, Aerts, Sophie, additional, Rebuzzi, Sara Elena, additional, Fornarini, Giuseppe, additional, Zoratto, Federica, additional, Fancelli, Sara, additional, Lupi, Alessio, additional, Della Corte, Carminia Maria, additional, Parisi, Alessandro, additional, Bennati, Chiara, additional, Ortega, Cinzia, additional, Atzori, Francesco, additional, Piovano, Pier Luigi, additional, Orciuolo, Corrado, additional, De Tursi, Michele, additional, Ghidini, Michele, additional, Botticelli, Andrea, additional, Scagnoli, Simone, additional, Belluomini, Lorenzo, additional, Leporati, Rita, additional, Veccia, Antonello, additional, Di Giacomo, Anna Maria, additional, Festino, Lucia, additional, Cortinovis, Diego, additional, Acquati, Mirko, additional, Filetti, Marco, additional, Giusti, Raffaele, additional, Tucci, Marco, additional, Sergi, Maria Chiara, additional, Garutti, Mattia, additional, Puglisi, Fabio, additional, Manglaviti, Sara, additional, Citarella, Fabrizio, additional, Santoni, Matteo, additional, Rijavec, Erika, additional, Lo Russo, Giuseppe, additional, Santini, Daniele, additional, Addeo, Alfredo, additional, Antonuzzo, Lorenzo, additional, Indini, Alice, additional, Rocchi, Marco Bruno Luigi, additional, Cortellini, Alessio, additional, Grossi, Francesco, additional, Ascierto, Paolo Antonio, additional, Aerts, Joachim G J V, additional, and Berardi, Rossana, additional

Published
2023
Full Text
View/download PDF

40. Pembrolizumab Plus Pemetrexed and Platinum in Nonsquamous Non–Small-Cell Lung Cancer: 5-Year Outcomes From the Phase 3 KEYNOTE-189 Study

Author

Garassino, Marina C., primary, Gadgeel, Shirish, additional, Speranza, Giovanna, additional, Felip, Enriqueta, additional, Esteban, Emilio, additional, Dómine, Manuel, additional, Hochmair, Maximilian J., additional, Powell, Steven F., additional, Bischoff, Helge G., additional, Peled, Nir, additional, Grossi, Francesco, additional, Jennens, Ross R., additional, Reck, Martin, additional, Hui, Rina, additional, Garon, Edward B., additional, Kurata, Takayasu, additional, Gray, Jhanelle E., additional, Schwarzenberger, Paul, additional, Jensen, Erin, additional, Pietanza, M. Catherine, additional, and Rodríguez-Abreu, Delvys, additional

Published
2023
Full Text
View/download PDF

41. Prognostic Role of Soluble and Extracellular Vesicle-Associated PD-L1, B7-H3 and B7-H4 in Non-Small Cell Lung Cancer Patients Treated with Immune Checkpoint Inhibitors

Author

Genova, Carlo, primary, Tasso, Roberta, additional, Rosa, Alessandra, additional, Rossi, Giovanni, additional, Reverberi, Daniele, additional, Fontana, Vincenzo, additional, Marconi, Silvia, additional, Croce, Michela, additional, Dal Bello, Maria Giovanna, additional, Dellepiane, Chiara, additional, Tagliamento, Marco, additional, Ciferri, Maria Chiara, additional, Zullo, Lodovica, additional, Fedeli, Alessandro, additional, Alama, Angela, additional, Cortese, Katia, additional, Gentili, Chiara, additional, Cella, Eugenia, additional, Anselmi, Giorgia, additional, Mora, Marco, additional, Barletta, Giulia, additional, Rijavec, Erika, additional, Grossi, Francesco, additional, Pronzato, Paolo, additional, and Coco, Simona, additional

Published
2023
Full Text
View/download PDF

42. Safety of extended interval dosing immune checkpoint inhibitors:a multicenter cohort study

Author

Cantini, Luca, Paoloni, Francesco, Pecci, Federica, Spagnolo, Francesco, Genova, Carlo, Tanda, Enrica Teresa, Aerts, Sophie, Rebuzzi, Sara Elena, Fornarini, Giuseppe, Zoratto, Federica, Fancelli, Sara, Lupi, Alessio, Della Corte, Carminia Maria, Parisi, Alessandro, Bennati, Chiara, Ortega, Cinzia, Atzori, Francesco, Piovano, Pier Luigi, Orciuolo, Corrado, De Tursi, Michele, Ghidini, Michele, Botticelli, Andrea, Scagnoli, Simone, Belluomini, Lorenzo, Leporati, Rita, Veccia, Antonello, Di Giacomo, Anna Maria, Festino, Lucia, Cortinovis, Diego, Acquati, Mirko, Filetti, Marco, Giusti, Raffaele, Tucci, Marco, Sergi, Maria Chiara, Garutti, Mattia, Puglisi, Fabio, Manglaviti, Sara, Citarella, Fabrizio, Santoni, Matteo, Rijavec, Erika, Lo Russo, Giuseppe, Santini, Daniele, Addeo, Alfredo, Antonuzzo, Lorenzo, Indini, Alice, Rocchi, Marco Bruno Luigi, Cortellini, Alessio, Grossi, Francesco, Ascierto, Paolo Antonio, Aerts, Joachim G.J.V., Berardi, Rossana, Cantini, Luca, Paoloni, Francesco, Pecci, Federica, Spagnolo, Francesco, Genova, Carlo, Tanda, Enrica Teresa, Aerts, Sophie, Rebuzzi, Sara Elena, Fornarini, Giuseppe, Zoratto, Federica, Fancelli, Sara, Lupi, Alessio, Della Corte, Carminia Maria, Parisi, Alessandro, Bennati, Chiara, Ortega, Cinzia, Atzori, Francesco, Piovano, Pier Luigi, Orciuolo, Corrado, De Tursi, Michele, Ghidini, Michele, Botticelli, Andrea, Scagnoli, Simone, Belluomini, Lorenzo, Leporati, Rita, Veccia, Antonello, Di Giacomo, Anna Maria, Festino, Lucia, Cortinovis, Diego, Acquati, Mirko, Filetti, Marco, Giusti, Raffaele, Tucci, Marco, Sergi, Maria Chiara, Garutti, Mattia, Puglisi, Fabio, Manglaviti, Sara, Citarella, Fabrizio, Santoni, Matteo, Rijavec, Erika, Lo Russo, Giuseppe, Santini, Daniele, Addeo, Alfredo, Antonuzzo, Lorenzo, Indini, Alice, Rocchi, Marco Bruno Luigi, Cortellini, Alessio, Grossi, Francesco, Ascierto, Paolo Antonio, Aerts, Joachim G.J.V., and Berardi, Rossana

Abstract

BACKGROUND: Real-life spectrum and survival implications of immune-related adverse events (irAEs) in patients treated with extended interval dosing (ED) immune checkpoint inhibitors (ICIs) are unknown. METHODS: Characteristics of 812 consecutive solid cancer patients who received at least 1 cycle of ED monotherapy (pembrolizumab 400 mg Q6W or nivolumab 480 mg Q4W) after switching from canonical interval dosing (CD; pembrolizumab 200 mg Q3W or nivolumab 240 mg Q2W) or treated upfront with ED were retrieved. The primary objective was to compare irAEs patterns within the same population (before and after switch to ED). irAEs spectrum in patients treated upfront with ED and association between irAEs and overall survival were also described. RESULTS: A total of 550 (68%) patients started ICIs with CD and switched to ED. During CD, 225 (41%) patients developed any grade and 17 (3%) G3 or G4 irAEs; after switching to ED, any grade and G3 or G4 irAEs were experienced by 155 (36%) and 20 (5%) patients. Switching to ED was associated with a lower probability of any grade irAEs (adjusted odds ratio [aOR] = 0.83, 95% confidence interval [CI] = 0.64 to 0.99; P = .047), whereas no difference for G3 or G4 events was noted (aOR = 1.55, 95% CI = 0.81 to 2.94; P = .18). Among patients who started upfront with ED (n = 232, 32%), 107 (41%) developed any grade and 14 (5%) G3 or G4 irAEs during ED. Patients with irAEs during ED had improved overall survival (adjusted hazard ratio [aHR] = 0.53, 95% CI = 0.34 to 0.82; P = .004 after switching; aHR = 0.57, 95% CI = 0.35 to 0.93; P = .025 upfront). CONCLUSIONS: Switching ICI treatment from CD and ED did not increase the incidence of irAEs and represents a safe option also outside clinical trials.

Published
2023

43. Afatinib beyond progression in patients with non-small-cell lung cancer following chemotherapy, erlotinib/gefitinib and afatinib: phase III randomized LUX-Lung 5 trial

Author

Ignatius Ou, SaiHong, Planchard, David, Park, Keunchil, Schuler, Martin, Yang, James, Chand, Vikram, Rohr, Klaus, Bagnes, Claudia, Martin, Claudio Marcelo, Recondo, Gonzalo, Zarba, Juan Jose, Blajman, Cesar, Richardet, Martín, McLachlan, Sue-Anne, Parente, Phillip, Underhill, Craig, Crombie, Catherine, Mainwaring, Paul, Greil, Richard, Humblet, Yves, Bustin, Frédérique, Carestia, Luciano, Galdermans, Danny, Lambrechts, Marc, Delval, Laetitia, Vercauter, Piet, Zhou, Caicun, Wang, Jin, Huang, Cheng, Lin, Xiaoyan, Wu, Yilong, Liu, Xiaoqing, Cheng, Ying, Qin, Shukui, Feng, Jifeng, Huang, Jianjin, Zhang, Yiping, Lu, Shun, Zereu, Manuela, Garicochea, Bernardo, Zadra, Cyntia Albuquerque, Riska, Henrik, Alanko, Tuomo, Cadranel, Jacques, Chouaid, Christos, Zalcman, Gérard, Sibilot, Denis Moro, Perol, Maurice, Bennouna, Jaafar, Fournel, Pierre, Gervais, Radj, Rotarski, Maciej, Coudert, Bruno, Thomas, Michael, Wehler, Thomas, Faehling, Martin, Keilholz, Ulrich, Laack, Eckart, von Pawel, Joachim, Huber, Rudolf, Dickgreber, Nicolas, Wiewrodt, Rainer, Mark, Zsuzsanna, Tehenes, Sandor, Strausz, Janos, Sarosi, Veronika, Prabhash, Kumar, Jain, Minish, Venkatesan, Srinivasan, Sharma, Lalit, Dadhich, Hemant, Nagarkar, Rajnish Vasant, Onn, Amir, Gottfried, Maya, Stemmer, Solomon, Migliorino, Maria Rita, Grossi, Francesco, Bidoli, Paolo, Bearz, Alessandra, Gridelli, Cesare, Milandri, Carlo, Platania, Marco, Ceresoli, Giovanni Luca, Cruciani, Giorgio, Delgado, Francisco Gutierrez, Gonzalez Perez, José Luis, Luna, Gabriela Alvarado, Baca, Othon Padilla, Aerts, J.G.J.V., Stigt, J.A., Dingemans, A.M.C., Herder, G.J.M., Gans, S.J.M., Salas Sánchez, Jorge Fernando, Alvarez Barreda, Renzo Luzgardo, Pantigoso, Wilbert Rodriguez, Palomino, Osbert Luis Mejia, Jaskiewicz, Piotr, Kazarnowicz, Andrzej, Serwatowski, Piotr, Szczesna, Aleksandra, Jassem, Jacek, Lubennikov, Vladimir, Karaseva, Nina, Orlov, Sergey, Ragulin, Yuri, Garrido, Pilar, González Larriba, José Luis, Camps, Carlos, Campelo, Rosario García, Lianes, Pilar, Cobo, Manuel, Felip, Enriqueta, Kim, Dong-Wan, Kim, Sang-We, Kim, Joo-Hang, Han, Ji-Youn, Kim, Young-Chul, Yang, Chih-Hsin, Hsia, Te-Chun, Chen, Yuh-Min, Tsai, Ying-Huang, Chang, Gee-Chen, Tsao, Thomas Chang-Yao, Su, Wu-Chou, Huang, Ming-Shyan, Ho, Ching-Liang, Hsieh, Ruey-Kuen, Vinnyk, Yuriy, Popovych, Oleksandr, Ponomarova, Olga, Bondarenko, Igor, Polishchuk, Iryna, Shah, Riyaz, Mitra, Sanka, Popat, Sanjaykumar, Spicer, James, Toy, Elizabeth, Talbot, Toby, Brown, Emma, Upadhyay, Sunil, Summers, Yvonne, Gurtler, Jayne, Meza, Luis, Thropay, John, Schuler, M., Yang, J.C.-H., Park, K., Kim, J.-H., Bennouna, J., Chen, Y.-M., Chouaid, C., De Marinis, F., Feng, J.-F., Grossi, F., Kim, D.-W., Liu, X., Lu, S., Strausz, J., Vinnyk, Y., Wiewrodt, R., Zhou, C., Wang, B., Chand, V.K., and Planchard, D.

Published
2016
Full Text
View/download PDF

45. Bone metastases and immunotherapy in patients with advanced non-small-cell lung cancer

Author

Landi, Lorenza, D’Incà, Federica, Gelibter, Alain, Chiari, Rita, Grossi, Francesco, Delmonte, Angelo, Passaro, Antonio, Signorelli, Diego, Gelsomino, Francesco, Galetta, Domenico, Giannarelli, Diana, Soto Parra, Hector, Minuti, Gabriele, Tiseo, Marcello, Migliorino, Maria Rita, Cognetti, Francesco, Toschi, Luca, Bidoli, Paolo, Piantedosi, Francovito, Calabro’, Luana, and Cappuzzo, Federico

Published
2019
Full Text
View/download PDF

47. Implementation of Precision Oncology in Clinical Practice: Results of a National Survey for Health Care Professionals

Author

Fasola, Gianpiero, primary, Barducci, Maria C, additional, Pelizzari, Giacomo, additional, Grossi, Francesco, additional, Pinto, Carmine, additional, Daniele, Bruno, additional, Giordano, Monica, additional, Ortega, Cinzia, additional, Silva, Rosa Rita, additional, Tozzi, Valeria D, additional, Cavanna, Luigi, additional, and Aprile, Giuseppe, additional

Published
2023
Full Text
View/download PDF

50. Rationale and design of a single-arm, phase 2, multi-center study of chemo-immunotherapy followed by hypo-fractionated RT and maintenance immunotherapy in patients with unresectable stage III NSCLC: the DEDALUS trial.

Author

Filippi, Andrea Riccardo, primary, Agustoni, Francesco, additional, Arcangeli, Stefano, additional, Cortinovis, Diego, additional, Ferrari, Alessandra, additional, Cicognini, Daniela, additional, Saddi, Jessica, additional, Klersy, Catherine, additional, Pedrazzoli, Paolo, additional, Malapelle, Umberto, additional, and Grossi, Francesco, additional

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results