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2 results on '"GYKI-52895"'

1. A SIMPLE AND EFFICIENT SYNTHESIS OF GYKI 52466 AND GYKI 52895

Author

Nicola Micale, Maria Zappalà, Santina Polimeni, Carlo De Micheli, and Silvana Grasso

Subjects
chemistry.chemical_compound, Safrole, Chemistry, Simple (abstract algebra), Organic Chemistry, medicine, GYKI-52895, AMPA Receptor Antagonists, Combinatorial chemistry, medicine.drug
Abstract

The synthesis of 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine (GYKI 52466, 1), the prototype of a series of noncompetitive AMPA receptor antagonists, and its 3,4-dihydroderivative (GYKI 52895, 2) is described. The title compounds have been prepared starting from safrole through a quite effective procedure.

Published
2002
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2. ChemInform Abstract: A Simple and Efficient Synthesis of GYKI 52466 and GYKI 52895

Author

Maria Zappalà, Santina Polimeni, Silvana Grasso, Nicola Micale, and Carlo De Micheli

Subjects
chemistry.chemical_compound, Safrole, chemistry, Simple (abstract algebra), medicine, General Medicine, GYKI-52895, AMPA Receptor Antagonists, Combinatorial chemistry, medicine.drug
Abstract

The synthesis of 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine (GYKI 52466, 1), the prototype of a series of noncompetitive AMPA receptor antagonists, and its 3,4-dihydroderivative (GYKI 52895, 2) is described. The title compounds have been prepared starting from safrole through a quite effective procedure.

Published
2010
Full Text
View/download PDF

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