1. [Pre-extensively and extensively drug-resistant tuberculosis, in Libreville, Gabon].
- Author
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Kombila UD, Manomba Boulingui C, N'Gomanda F, Mouity Mavoungou JV, Ngea Epossi CBH, Bivigou N, Tsioukaka S, Tshisekedi JDD, Mahoumbou J, and Boguikouma JB
- Subjects
- Humans, Gabon epidemiology, Female, Male, Adult, Retrospective Studies, Middle Aged, Young Adult, HIV Infections epidemiology, HIV Infections complications, HIV Infections drug therapy, Coinfection epidemiology, Coinfection microbiology, Extensively Drug-Resistant Tuberculosis epidemiology, Extensively Drug-Resistant Tuberculosis drug therapy, Antitubercular Agents therapeutic use, Mycobacterium tuberculosis isolation & purification, Mycobacterium tuberculosis drug effects, Tuberculosis, Multidrug-Resistant epidemiology, Tuberculosis, Multidrug-Resistant drug therapy
- Abstract
Introduction: Very few studies have been devoted to extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (TB) in Gabon., Aim: The aim of the present study is to present the epidemiology of pre-XDR and XDR TB and the evolution over time of patients with multidrug-resistant TB., Methods: This retrospective study covered the activities from 2019 to 2022 of the Nkembo anti-tuberculosis center., Results: Fifteen patients were eligible, including 11 (73.3%) pre-XDR patients and 4 (26.7%) XDR-TB patients. Three (20.0%) patients had HIV/TB co-infection. The sample consisted of 7 men (46.7%) and 8 women (53.3%), a sex ratio (M/F) of 0.87. The average age was 35.6 years, and the median 34 years, with extremes of 23 and 60 years. Eight patients (53.3%) represented new cases of pre-XDR or XDR-TB tuberculosis. The majority (60%; n=9) came from deprived neighborhoods with widespread promiscuity. The therapeutic success rate among pre-XDR patients was 4 (36.4%) versus 2 (50.0%) among XDR-TB patients. Reported mortality occurred 5 (33.3%) patients during treatment, including 3 pre-XDR and 2 XDR-TB patients. In all cases, they died before the end of the first trimester of follow-up., Conclusion: The high frequency of primary pre-extensively drug-resistant tuberculosis underscores the pervasiveness of resistance to anti-tuberculosis drugs and underlines a pressing need for detection of contact cases and early treatment., (Copyright © 2024 SPLF. Published by Elsevier Masson SAS. All rights reserved.)
- Published
- 2024
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