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888 results on '"Gafter-Gvili, Anat"'

35. A systematic review and meta-analysis of nonrelapse mortality after CAR T cell therapy

Author

Cordas dos Santos, David M., Tix, Tobias, Shouval, Roni, Gafter-Gvili, Anat, Alberge, Jean-Baptiste, Cliff, Edward R. Scheffer, Theurich, Sebastian, von Bergwelt-Baildon, Michael, Ghobrial, Irene M., Subklewe, Marion, Perales, Miguel-Angel, and Rejeski, Kai

Abstract

Although chimeric antigen receptor (CAR) T cell therapy represents a transformative immunotherapy, it is also associated with distinct toxicities that contribute to morbidity and mortality. In this systematic review and meta-analysis, we searched MEDLINE, Embase and CINAHL (Cochrane) for reports of nonrelapse mortality (NRM) after CAR T cell therapy in lymphoma and multiple myeloma up to March 2024. After extraction of causes and numbers of death, we analyzed NRM point estimates using random-effect models. We identified 7,604 patients across 18 clinical trials and 28 real-world studies. NRM point estimates varied across disease entities and were highest in patients with mantle-cell lymphoma (10.6%), followed by multiple myeloma (8.0%), large B cell lymphoma (6.1%) and indolent lymphoma (5.7%). Entity-specific meta-regression models for large B cell lymphoma and multiple myeloma revealed that axicabtagene ciloleucel and ciltacabtagene autoleucel were independently associated with increased NRM point estimates, respectively. Of 574 reported nonrelapse deaths, over half were attributed to infections (50.9%), followed by other malignancies (7.8%) and cardiovascular/respiratory events (7.3%). Conversely, the CAR T cell-specific side effects, immune effector cell-associated neurotoxicity syndrome/neurotoxicity, cytokine release syndrome and hemophagocytic lymphohistiocytosis, represented only a minority of nonrelapse deaths (cumulatively 11.5%). Our findings underline the critical importance of infectious complications after CAR T cell therapy and support the comprehensive reporting of NRM, including specific causes and long-term outcomes.

Published
2024
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37. Rituximab maintenance improves overall survival of patients with follicular lymphoma—Individual patient data meta-analysis

Author

Vidal, Liat, Gafter-Gvili, Anat, Salles, Gilles, Bousseta, Sami, Oberman, Bernice, Rubin, Carmit, van Oers, Marinus H.J., Fortpied, Catherine, Ghielmini, Michele, Pettengell, Ruth, Witzens-Harig, Mathias, Dreger, Peter, Vitolo, Umberto, Gomes da Silva, Maria, Evangelista, Andrea, Li, Hailun, Freedman, Laurence, Habermann, Thomas M., and Shpilberg, Ofer

Published
2017
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40. Extracorporeal photopheresis induces NETosis in neutrophils derived from patients with chronic graft‐vs‐host disease.

Author

Goldberg, Idan, Granot, Galit, Telerman, Alona, Partouche, Shirly, Shochat, Tzippy, Halperin, Erez, Gafter‐Gvili, Anat, Shargian, Liat, Yeshurun, Moshe, Raanani, Pia, Wolach, Ofir, and Yahalom, Vered

Subjects
GRAFT versus host disease, CHRONICALLY ill, LEUCOCYTE elastase, NEUTROPHILS
Abstract

Introduction: Extracorporeal photopheresis (ECP) is considered an effective treatment for patients with chronic graft vs host disease (cGVHD) and demonstrates efficacy in ameliorating GVHD. The mechanism by which ECP acts against cGVHD is not fully understood. Preliminary observations have hinted at the potential involvement of neutrophil extracellular traps (NETs) formation in the pathogenesis of cGVHD. We aimed to assess the influence of ECP on the formation of NETs in patients with cGVHD as a potential mechanism in this setting. Methods: Patients treated with ECP for cGVHD at the Rabin Medical Center were included in this study. Blood samples were obtained at three different time points: before starting an ECP cycle, at the end of the first day of treatment, and 24 h following the initiation of the ECP treatment cycle. Neutrophils were harvested from all blood samples. NET formation was assessed by measurement of NET‐bound specific neutrophil elastase activity and by immunofluorescence staining. Results: Six patients (two females and four males) with cGVHD were included in the study. We observed a significant increase in NET formation among all six patients following ECP. Net‐bound specific neutrophil elastase activity was elevated from a median value of 2.23 mU/mL (interquartile range [IQR] 2.06‐2.47 mU/mL) at baseline to a median value of 13.06 mU/mL (IQR 10.27‐15.97 mU/mL) immediately after the treatment and to a peak median value of 14.73 mU/mL (IQR 9.6‐22.38 mU/mL) 24 h following the initiation of the ECP cycle. A qualitative assessment of NET formation using immunofluorescence staining has demonstrated markedly increased expression of citrullinated histone H3, a marker of NET formation, following ECP treatment. Conclusions: Our preliminary data indicate that ECP induces NET formation among patients with cGVHD. The contribution of increased NET formation to the therapeutic effect of cGVHD should be further investigated. [ABSTRACT FROM AUTHOR]

Published
2023
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45. A Case of Rickettsiosis in a Patient with Glucose-6-Phosphate Dehydrogenase (G6pd) Deficiency

Author

Garin-kol Avrahami Reut, Zerbib Olivier, Gafter Gvili Anat, Lev Shaul, Gal Sahaf Levin, and Gottesman Tamar

Abstract

Rickettsia is a group of Gram-negative intra cellular obligatory bacteria. Rickettsia species are an important cause of infectious disease in people and animals. Fleas, ticks, mite, lice etc., serve as vectors who transfer the rickettsia from animal to humans.Rickettsiosis is one of the oldest known vector-borne diseases(Blanda et al., 2020). Usually it is a nonspecific self-limiting febrile illness without major complications. Fever, headache, mild-rash, myalgia's and anorexia are the most common presenting signs and symptoms. Laboratory findings include elevated transaminase levels, hyponatremia, thrombocytopenia and anemia (Merhej et al., 2014). The disease is usually of benign nature. Severe complications are reported in about 6% of cases. Patients may present with organ involvement, severe vasculitis and multi organ failure (Oteo and Portillo, 2012) and the mortality rate is up to 2.5%(Giammanco et al., 2005; Raoult et al., 1986).

Published
2022

46. A Systematic Review Assessing the Underrepresentation of Cancer Patients in COVID-19 Trials

Author

Buchrits, Shira, Fredman, Danielle, Ben Tikva Kagan, Kim, and Gafter-Gvili, Anat

Subjects
Systematic Review, Hematology, General Medicine
Abstract

Background: The new severe acute respiratory syndrome coronavirus 2 has emerged as a global pandemic that threatens thousands around the world. Observational cohort studies have demonstrated that cancer patients have inferior outcomes due to underlying malignancy, treatment-related immunosuppression, or increased comorbidities. We aimed to examine the representation of cancer patients (hematological malignancies and solid tumors) in COVID-19 therapeutic and prophylactic interventional trials. Methods: In this review, all randomized controlled trials (RCTs) published between December 2019 and August 2021 were included. We included only trials evaluating medications that were recommended by NIH guidelines: steroids, tocilizumab, remdesivir, and REGN-COV2. Results: The search yielded 541 potentially relevant RCTs, 22 of which were considered suitable. All trials included patients with solid cancer and hematological malignancies in the formal reported inclusion criteria. However, only two trials reported the accurate number of cancer patients included. Ten trials excluded neutropenic patients and seven trials excluded thrombocytopenic patients. Eleven trials excluded patients that were treated with any immunosuppression treatment. None of the two trials that included cancer patients reported separate outcomes for this population. Conclusion: Our systematic review shows that cancer patients are underrepresented in COVID-19 interventional therapeutic trials, and evidence regarding outcomes are lacking.

Published
2022

48. Is there a 'weekend effect' on mortality among hospitalised patients in an internal medicine ward? A retrospective study.

Author

Lavie, Inbar, Lavie, Michael, Dayan, Ofek, Gafter‐Gvili, Anat, Yahav, Dafna, Kozlovski, Dror, and Avni, Tomer

Subjects
CAUSES of death, SHIFT systems, INTERNAL medicine, SCIENTIFIC observation, CONFIDENCE intervals, TIME, PATIENTS, RETROSPECTIVE studies, ACQUISITION of data, HOSPITAL mortality, HOSPITAL admission & discharge, RISK assessment, COMPARATIVE studies, HOSPITAL wards, DESCRIPTIVE statistics, MEDICAL records, HOSPITAL care of older people, STATISTICAL models, LONGITUDINAL method
Abstract

Background: Previous studies demonstrated a 'weekend effect' and a 'night effect' of increased mortality among patients admitted during weekends or night shifts, presumably due to understaffing. Aims: To examine whether death during hospitalisation follows a similar effect regardless of admission time. Methods: A retrospective cohort study among deceased patients hospitalised in the internal medicine wing of a tertiary medical centre in Israel, between 2019 and 2020. Demographic and medical data were retrieved from electronic medical charts. Causes of death were specifically categorised. We applied statistical models to test for differences in mortality using incidence rate ratio (IRR) according to the day, time and cause of death. Results: One thousand, two hundred and seventy‐eight deceased patients were included. All‐cause mortality was similar between weekends and weekdays. When sepsis was the cause of death, higher IRR were demonstrated on Fridays in comparison with weekdays (IRR 1.4; 95% confidence interval (CI) 1.1–1.9; P < 0.05). Other causes of death were not consistent with a 'weekend effect'. Mortality during night shifts was higher in comparison with the afternoon (IRR 1.5; 95% CI 1.3–4.7) and similar to the morning (IRR 1; 95% CI 0.9–1.2). Conclusion: Our study did not find a pattern of 'weekend effect' or 'night effect' on all‐cause mortality among hospitalised patients in internal medicine wards. Our findings suggest that perhaps specifically death from sepsis, and not all‐cause mortality, can be used as a surrogate for the measurement of understaffing or quality of care in the internal ward. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Higher Infection Rate After 7- Compared With 5-Day Cycle of Azacitidine in Patients With Higher-Risk Myelodysplastic Syndrome

Author

Ofran, Yishai, Filanovsky, Kalman, Gafter-Gvili, Anat, Vidal, Liat, Aviv, Ariel, Gatt, Moshe E., Silbershatz, Itay, Herishanu, Yair, Arad, Ariela, Tadmor, Tamar, Dally, Najib, Nemets, Anatoly, Rouvio, Ory, Ronson, Aharon, Herzog-Tzarfati, Katrin, Akria, Luiza, Braester, Andrei, Hellmann, Ilana, Yeganeh, Shay, Nagler, Arnon, Leiba, Ronit, Mittelman, Moshe, and Merkel, Drorit

Published
2015
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