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2. Asset management for the ELT

Author

Egner, Sébastien E., Roberts, Scott, Egner, Sebastien, Hamilton, Robert, Gago, Fernando, Guzman, Ronald, González, Sergio, Serrano, Dario, Escarlate, Nathalia, Gnatz, Amelie, Gonzalez, Javier, Gonzalez-Herrera, Juan Carlos, Kurlandczyk, Herve, Jaeger, Matias, Montironi, Katia, Morales, Alex, Phillips, Judith, and Siclari, Waldo

Published
2024
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3. Status of the ELT phasing and diagnostic station project

Author

Egner, Sébastien E., Roberts, Scott, Pettazzi, Lorenzo, Pfrommer, Thomas, Lewis, Steffan, Abad, Jose Antonio, Araujo Hauck, Constanza, Bedigan, Helen, Bonnet, Henri, Bourget, Pierre, Brinkmann, Martin, Calmette, Elsa, Cortes, Angela, Engler, Byron, Frank, Christoph, Gago, Fernando, Grudzien, Thomas, Guidolin, Ivan Maria, Haimerl, Andreas, Hammersley, Peter, Haug, Marcus, Hinterschuster, Renate, Huber, Stefan, Jolley, Paul, Kellerer, Aglae, Kiekebusch, Mario, Kirchbauer, Jean-Paul, Kolmeder, Johannes, Kosmalski, Johan, Lampater, Ulrich, La Penna, Paolo, Leveratto, Serban, Lucuix, Christian, Lopez Gil, Ignacio, Mandla, Christopher, Marchetti, Enrico, Moins, Christophe, Paufique, Jerome, Pfuhl, Oliver, Popovic, Dan, Sedghi, Babak, Tordo, Sebastien, Verinaud, Christophe, and Zuluaga, Pablo

Published
2024
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5. p53 stabilisation potentiates [177Lu]Lu-DOTATATE treatment in neuroblastoma xenografts.

Author

Berglund, Hanna, Salomonsson, Sara Lundsten, Mohajershojai, Tabassom, Gago, Fernando Jose Ferrer, Lane, David P., and Nestor, Marika

Subjects
DNA repair, NEUROBLASTOMA, XENOGRAFTS, DOSE-response relationship (Radiation), SURVIVAL rate, DRUG target, LUTETIUM compounds
Abstract

Purpose: Molecular radiotherapy is a treatment modality that is highly suitable for targeting micrometastases and [177Lu]Lu-DOTATATE is currently being explored as a potential novel treatment option for high-risk neuroblastoma. p53 is a key player in the proapoptotic signalling in response to radiation-induced DNA damage and is therefore a potential target for radiosensitisation. Methods: This study investigated the use of the p53 stabilising peptide VIP116 and [177Lu]Lu-DOTATATE, either alone or in combination, for treatment of neuroblastoma tumour xenografts in mice. Initially, the uptake of [177Lu]Lu-DOTATATE in the tumours was confirmed, and the efficacy of VIP116 as a monotherapy was evaluated. Subsequently, mice with neuroblastoma tumour xenografts were treated with placebo, VIP116, [177Lu]Lu-DOTATATE or a combination of both agents. Results: The results demonstrated that monotherapy with either VIP116 or [177Lu]Lu-DOTATATE significantly prolonged median survival compared to the placebo group (90 and 96.5 days vs. 50.5 days, respectively). Notably, the combination treatment further improved median survival to over 120 days. Furthermore, the combination group exhibited the highest percentage of complete remission, corresponding to a twofold increase compared to the placebo group. Importantly, none of the treatments induced significant nephrotoxicity. Additionally, the therapies affected various molecular targets involved in critical processes such as apoptosis, hypoxia and angiogenesis. Conclusion: In conclusion, the combination of VIP116 and [177Lu]Lu-DOTATATE presents a promising novel treatment approach for neuroblastoma. These findings hold potential to advance research efforts towards a potential cure for this vulnerable patient population. [ABSTRACT FROM AUTHOR]

Published
2024
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6. p53 stabilisation potentiates [177Lu]Lu-DOTATATE treatment in neuroblastoma xenografts

Author

Berglund, Hanna, Lundsten Salomonsson, Sara, Mohajershojai, Tabassom, Ferrer Gago, Fernando Jose, Lane, David P., Nestor, Marika, Berglund, Hanna, Lundsten Salomonsson, Sara, Mohajershojai, Tabassom, Ferrer Gago, Fernando Jose, Lane, David P., and Nestor, Marika

Abstract

Purpose Molecular radiotherapy is a treatment modality that is highly suitable for targeting micrometastases and [177Lu]Lu-DOTATATE is currently being explored as a potential novel treatment option for high-risk neuroblastoma. p53 is a key player in the proapoptotic signalling in response to radiation-induced DNA damage and is therefore a potential target for radiosensitisation. Methods This study investigated the use of the p53 stabilising peptide VIP116 and [177Lu]Lu-DOTATATE, either alone or in combination, for treatment of neuroblastoma tumour xenografts in mice. Initially, the uptake of [177Lu]Lu-DOTATATE in the tumours was confirmed, and the efficacy of VIP116 as a monotherapy was evaluated. Subsequently, mice with neuroblastoma tumour xenografts were treated with placebo, VIP116, [177Lu]Lu-DOTATATE or a combination of both agents. Results The results demonstrated that monotherapy with either VIP116 or [177Lu]Lu-DOTATATE significantly prolonged median survival compared to the placebo group (90 and 96.5 days vs. 50.5 days, respectively). Notably, the combination treatment further improved median survival to over 120 days. Furthermore, the combination group exhibited the highest percentage of complete remission, corresponding to a twofold increase compared to the placebo group. Importantly, none of the treatments induced significant nephrotoxicity. Additionally, the therapies affected various molecular targets involved in critical processes such as apoptosis, hypoxia and angiogenesis. Conclusion In conclusion, the combination of VIP116 and [177Lu]Lu-DOTATATE presents a promising novel treatment approach for neuroblastoma. These findings hold potential to advance research efforts towards a potential cure for this vulnerable patient population., De två första författarna delar förstaförfattarskapet

Published
2023
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10. EMIR Detector Characterization

Author

Díaz, José Javier, Gago, Fernando, González-Fernández, Carlos, Beigbeder, Francis, Garzón, Francisco, Patrón, Jesús, Beletic, Jenna E., editor, Beletic, James W., editor, and Amico, Paola, editor

Published
2006
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11. Emir HAWAII-2 Detector Test Bench

Author

Díaz, José J., Gago, Fernando, Beigbeder, Francis, Garzón, Francisco, Patrón1, Jesús, Burton, W. B., editor, Kuijpers, J. M. E., editor, Van Den Heuvel, E. P. J., editor, Van Der Laan, H., editor, Amico, Paola, editor, Beletic, James W., editor, and Beletic, Jenna E., editor

Published
2004
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12. Emir HAWAII-II First Test Results

Author

Díaz, José J., Gago, Fernando, Beigbeder, Francis, Garzón, Francisco, Patrón, Jesús, Burton, W. B., editor, Kuijpers, J. M. E., editor, Van Den Heuvel, E. P. J., editor, Van Der Laan, H., editor, Amico, Paola, editor, Beletic, James W., editor, and Beletic, Jenna E., editor

Published
2004
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13. Macrocyclization of an all-d linear α-helical peptide imparts cellular permeability† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc06383h

Author

Kannan, Srinivasaraghavan, Aronica, Pietro G. A., Ng, Simon, Gek Lian, Dawn Thean, Frosi, Yuri, Chee, Sharon, Shimin, Jiang, Yuen, Tsz Ying, Sadruddin, Ahmad, Kaan, Hung Yi Kristal, Chandramohan, Arun, Wong, Jin Huei, Tan, Yaw Sing, Chang, Zi Wei, Ferrer-Gago, Fernando J., Arumugam, Prakash, Han, Yi, Chen, Shiying, Rénia, Laurent, Brown, Christopher J., Johannes, Charles W., Henry, Brian, Lane, David P., Sawyer, Tomi K., Verma, Chandra S., and Partridge, Anthony W.

Subjects
Chemistry
Abstract

Peptide-based molecules hold great potential as targeted inhibitors of intracellular protein–protein interactions (PPIs)., Peptide-based molecules hold great potential as targeted inhibitors of intracellular protein–protein interactions (PPIs). Indeed, the vast diversity of chemical space conferred through their primary, secondary and tertiary structures allows these molecules to be applied to targets that are typically deemed intractable via small molecules. However, the development of peptide therapeutics has been hindered by their limited conformational stability, proteolytic sensitivity and cell permeability. Several contemporary peptide design strategies are aimed at addressing these issues. Strategic macrocyclization through optimally placed chemical braces such as olefinic hydrocarbon crosslinks, commonly referred to as staples, may improve peptide properties by (i) restricting conformational freedom to improve target affinities, (ii) improving proteolytic resistance, and (iii) enhancing cell permeability. As a second strategy, molecules constructed entirely from d-amino acids are hyper-resistant to proteolytic cleavage, but generally lack conformational stability and membrane permeability. Since neither approach is a complete solution, we have combined these strategies to identify the first examples of all-d α-helical stapled and stitched peptides. As a template, we used a recently reported all d-linear peptide that is a potent inhibitor of the p53–Mdm2 interaction, but is devoid of cellular activity. To design both stapled and stitched all-d-peptide analogues, we used computational modelling to predict optimal staple placement. The resultant novel macrocyclic all d-peptide was determined to exhibit increased α-helicity, improved target binding, complete proteolytic stability and, most notably, cellular activity.

Published
2020

14. EMIR: the GTC NIR multi-object imager spectrograph

Author

Universidad EAFIT. Departamento de Ciencias Básicas, Óptica Aplicada, Garzón, Francisco, Abreu, David, Barrera, Sonia, Correa, Santiago, Díaz, Jose, Fragoso, Ana, Fuentes, F.J, Gago, Fernando, Gonzalez, Carlos, López, Pablo, Manescau, Antonio, Patrón, Jesus, Pérez, Jaime, Redondo, Pablo, R. Restrepo, Sánchez, Vicente, Villegas, Alejandro, Universidad EAFIT. Departamento de Ciencias Básicas, Óptica Aplicada, Garzón, Francisco, Abreu, David, Barrera, Sonia, Correa, Santiago, Díaz, Jose, Fragoso, Ana, Fuentes, F.J, Gago, Fernando, Gonzalez, Carlos, López, Pablo, Manescau, Antonio, Patrón, Jesus, Pérez, Jaime, Redondo, Pablo, R. Restrepo, Sánchez, Vicente, and Villegas, Alejandro

Abstract

We present the final global design and performances of EMIR, the NIR multi-object spectrograph of the GTC, as well as the plan for its early scientific exploitation.

Published
2021

15. A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma

Author

Johansson, Patrik, Krona, Cecilia, Kundu, Soumi, Doroszko, Milena, Baskaran, Sathishkumar, Schmidt, Linnea, Vinel, Claire, Almstedt, Elin, Elgendy, Ramy, Elfineh, Lioudmila, Gallant, Caroline J., Lundsten, Sara, Gago, Fernando J. Ferrer, Hakkarainen, Aleksi, Sipila, Petra, Haggblad, Maria, Martens, Ulf, Lundgren, Bo, Frigault, Melanie M., Lane, David P., Swartling, Fredrik J, Uhrbom, Lene, Nestor, Marika, Marino, Silvia, Nelander, Sven, Johansson, Patrik, Krona, Cecilia, Kundu, Soumi, Doroszko, Milena, Baskaran, Sathishkumar, Schmidt, Linnea, Vinel, Claire, Almstedt, Elin, Elgendy, Ramy, Elfineh, Lioudmila, Gallant, Caroline J., Lundsten, Sara, Gago, Fernando J. Ferrer, Hakkarainen, Aleksi, Sipila, Petra, Haggblad, Maria, Martens, Ulf, Lundgren, Bo, Frigault, Melanie M., Lane, David P., Swartling, Fredrik J, Uhrbom, Lene, Nestor, Marika, Marino, Silvia, and Nelander, Sven

Abstract

Glioblastoma (GBM) is a malignant brain tumor with few therapeutic options. The disease presents with a complex spectrum of genomic aberrations, but the pharmacological consequences of these aberrations are partly unknown. Here, we report an integrated pharmacogenomic analysis of 100 patient-derived GBM cell cultures from the human glioma cell culture (HGCC) cohort. Exploring 1,544 drugs, we find that GBM has two main pharmacological subgroups, marked by differential response to proteasome inhibitors and mutually exclusive aberrations in TP53 and CDKN2A/B. We confirm this trend in cell and in xenotransplantation models, and identify both Bcl-2 family inhibitors and p53 activators as potentiators of proteasome inhibitors in GBM cells, We can further predict the responses of individual cell cultures to several existing drug classes, presenting opportunities for drug repurposing and design of stratified trials. Our functionally profiled biobank provides a valuable resource for the discovery of new treatments for GBM., Patrik Johansson, Cecilia Krona and Soumi Kundu share first authorship

Published
2020
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16. NanoClick: A High Throughput, Target-Agnostic Peptide Cell Permeability Assay

Author

Peier, Andrea, primary, Ge, Lan, additional, Boyer, Nicolas, additional, Frost, John, additional, Duggal, Ruchia, additional, Biswas, Kaustav, additional, Edmondson, Scott, additional, Hermes, Jeffrey D., additional, Yan, Lin, additional, Zimprich, Chad, additional, Sadruddin, Ahmad, additional, Kristal Kaan, Hung Yi, additional, Chandramohan, Arun, additional, Brown, Christopher J., additional, Thean, Dawn, additional, Lee, Xue Er, additional, Yuen, Tsz Ying, additional, Ferrer-Gago, Fernando J., additional, Johannes, Charles W., additional, Lane, David P., additional, Sherborne, Brad, additional, Corona, Cesear, additional, Robers, Matthew B., additional, Sawyer, Tomi K., additional, and Partridge, Anthony W., additional

Published
2021
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18. A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma

Author

Johansson, Patrik, primary, Krona, Cecilia, additional, Kundu, Soumi, additional, Doroszko, Milena, additional, Baskaran, Sathishkumar, additional, Schmidt, Linnéa, additional, Vinel, Claire, additional, Almstedt, Elin, additional, Elgendy, Ramy, additional, Elfineh, Ludmila, additional, Gallant, Caroline, additional, Lundsten, Sara, additional, Ferrer Gago, Fernando J., additional, Hakkarainen, Aleksi, additional, Sipilä, Petra, additional, Häggblad, Maria, additional, Martens, Ulf, additional, Lundgren, Bo, additional, Frigault, Melanie M., additional, Lane, David P., additional, Swartling, Fredrik J., additional, Uhrbom, Lene, additional, Nestor, Marika, additional, Marino, Silvia, additional, and Nelander, Sven, additional

Published
2020
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19. De-risking Drug Discovery of Intracellular Targeting Peptides: Screening Strategies to Eliminate False-Positive Hits

Author

Ng, Simon, primary, Juang, Yu-Chi, additional, Chandramohan, Arun, additional, Kaan, Hung Yi Kristal, additional, Sadruddin, Ahmad, additional, Yuen, Tsz Ying, additional, Ferrer-Gago, Fernando J., additional, Lee, Xue’Er Cheryl, additional, Liew, Xi, additional, Johannes, Charles W., additional, Brown, Christopher J., additional, Kannan, Srinivasaraghavan, additional, Aronica, Pietro G., additional, Berglund, Nils A., additional, Verma, Chandra S., additional, Liu, Lijuan, additional, Stoeck, Alexander, additional, Sawyer, Tomi K., additional, Partridge, Anthony W., additional, and Lane, David P., additional

Published
2020
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21. Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design

Author

Tan, Yaw Sing, Reeks, Judith, Brown, Christopher J., Thean, Dawn, Ferrer Gago, Fernando Jose, Yuen, Tsz Ying, Goh, Eunice Tze Leng, Lee, Xue Er Cheryl, Jennings, Claire E., Joseph, Thomas L., Lakshminarayanan, Rajamani, Lane, David P., Noble, Martin E. M., and Verma, Chandra S.

Subjects
Models, Molecular, Letter, Binding Sites, Benzene, Molecular Dynamics Simulation, Ligands, Protein Binding
Abstract

Protein flexibility poses a major challenge in binding site identification. Several computational pocket detection methods that utilize small-molecule probes in molecular dynamics (MD) simulations have been developed to address this issue. Although they have proven hugely successful at reproducing experimental structural data, their ability to predict new binding sites that are yet to be identified and characterized has not been demonstrated. Here, we report the use of benzenes as probe molecules in ligand-mapping MD (LMMD) simulations to predict the existence of two novel binding sites on the surface of the oncoprotein MDM2. One of them was serendipitously confirmed by biophysical assays and X-ray crystallography to be important for the binding of a new family of hydrocarbon stapled peptides that were specifically designed to target the other putative site. These results highlight the predictive power of LMMD and suggest that predictions derived from LMMD simulations can serve as a reliable basis for the identification of novel ligand binding sites in structure-based drug design.

Published
2016

24. Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles

Author

Yuen, Tsz Ying, primary, Brown, Christopher J., additional, Xue, Yuezhen, additional, Tan, Yaw Sing, additional, Ferrer Gago, Fernando J., additional, Lee, Xue Er, additional, Neo, Jin Yong, additional, Thean, Dawn, additional, Kaan, Hung Yi Kristal, additional, Partridge, Anthony W., additional, Verma, Chandra S., additional, Lane, David P., additional, and Johannes, Charles W., additional

Published
2019
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25. Synthesis of C‐terminal glycine‐rich o‐aminoanilide peptides without overacylation for use in benzotriazole‐mediated native chemical ligation.

Author

Ferrer‐Gago, Fernando J. and Koh, Li Quan

Subjects
*BENZOTRIAZOLE derivatives, *GLYCINE, *PHENYLENEDIAMINES, *AMINO acid synthesis, *PEPTIDES, *PEPTIDE synthesis
Abstract

Native chemical ligation (NCL) requires the constant development of methods that facilitate the efficient synthesis of C‐terminal peptide thioesters, which are key intermediates in NCL. After testing several resins and linkers, we have developed a solid support on the Rink and chlorotrityl chloride resins based on the attachment of o‐phenylenediamine (PheDA), with and without an electron withdrawing group. These linkers enable the synthesis of C‐terminus o‐aminoanilide peptides without overacylation when the glycine is the first amino acid in the synthesis or when we have a glycine‐rich sequence. Upon treatment with NaNO2, the glycine o‐aminoanilide peptides produce C‐terminus benzotriazole (Bt) peptides. The C‐terminus‐Bt peptides undergo thiol exchange, yielding thioester peptides, which can then be used in an NCL reaction. The linkers attached to the Rink and CT resins efficiently avoid overacylation in the synthesis of glycine‐rich sequences, increasing the yield and purity of these sequences. [ABSTRACT FROM AUTHOR]

Published
2021
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26. Functionalized Resins for the Synthesis of Peptide Alcohols.

Author

Ferrer‐Gago, Fernando J., Koh, Li Quan, and Lane, David P.

Subjects
*PEPTIDE synthesis, *DICHLOROMETHANE, *ALCOHOL, *TRIFLUOROACETIC acid, *STRUCTURE-activity relationships, *POLYWATER, *GUM arabic
Abstract

Peptide alcohols are clinically important compounds that are underexplored in structure–activity relationship (SAR) studies in drug discovery. One reason for this underutilization is that current syntheses are laborious and time consuming. Herein, we describe the preparation and utility of Rink, Ramage, and Sieber‐chloride resins, which enables the use of a general, easy and practical method for the attachment of fluorenylmethoxycarbonyl (Fmoc)‐amino alcohols to a solid support, in the synthesis of peptide alcohols. This method is the first straightforward Fmoc/tBu synthesis of peptide alcohols starting from a pre‐loaded resin. The synthesized peptide alcohols can be detached from the linkers through conventional methods. Treatment with trifluoroacetic acid (TFA) (95 %) and scavengers such as triisopropylsilane and water for 2 h is sufficient to obtain a fully deprotected peptide alcohol, while treatment with 20 % hexafluoroisopropanol in dichloromethane renders a fully protected peptide alcohol that can be further modified at the C‐terminus. As examples, the new resins were used in straightforward, relatively rapid syntheses of the peptide alcohols octreotide, alamethicin, and a segment of trichogin GA IV, as well as the first synthesis of stapled peptide alcohols. [ABSTRACT FROM AUTHOR]

Published
2020
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28. EMIR Detector Characterization

Author

Díaz, José Javier, primary, Gago, Fernando, additional, González-Fernández, Carlos, additional, Beigbeder, Francis, additional, Garzón, Francisco, additional, and Patrón, Jesús, additional

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30. Improved Control Electronics for OSIRIS-GTC Commercial Tunable Filters

Author

Gigante, José V., primary, Herrera, Guillermo A., additional, Rasilla, José L., additional, Joven, Enrique, additional, Aguiar, Marta, additional, Herrera, Alberto, additional, López, José C., additional, Gonz´lez, Victor, additional, Gago, Fernando, additional, Pérez, Ángeles, additional, Valido, M. Rodríguez, additional, and Cepa, Jordi, additional

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32. EMIR high-dynamic range readout modes

Author

Nuñez, Miguel, primary, Gago, Fernando, additional, Garzón, Francisco, additional, Díaz, José J., additional, Barreto, Mary, additional, Patrón, Jesús, additional, González-Fenández, Carlos, additional, Hammersley, Peter L., additional, López, Luis, additional, and Castro, Nieves, additional

Published
2012
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33. OSIRIS tunable imager and spectrograph for the GTC: from design to commissioning

Author

Sánchez, Beatriz, primary, Aguiar-González, Marta, additional, Barreto, Roberto, additional, Becerril, Santiago, additional, Bland-Hawthorn, Joss, additional, Bongiovanni, Angel, additional, Cepa, Jordi, additional, Correa, Santiago, additional, Chapa, Oscar, additional, Ederoclite, Alessandro, additional, Espejo, Carlos, additional, Farah, Alejandro, additional, Fragoso, Ana Belén, additional, Fernández, Patricia, additional, Flores, Rubén, additional, Fuentes, F. Javier, additional, Gago, Fernando, additional, Garfias, Fernando, additional, Gigante, José Vicente, additional, González, Jesús, additional, González-Escalera, Victor, additional, Hernández, Belén, additional, Hernandez, Elvio, additional, Herrera, Alberto, additional, Herrera, Guillermo, additional, Joven, Enrique, additional, Langarica, Rosalia, additional, Lara, Gerardo, additional, López, José Carlos, additional, López, Roberto, additional, Militellon, Carmelo, additional, Moreno, Heidy, additional, Peraza, Lorenzo, additional, Pérez, Angeles, additional, Pérez, Jaime, additional, Rasilla, José Luis, additional, Rosich, Josefina, additional, Tejada, Carlos, additional, Tinoco, Silvio, additional, Vaz, Txinto, additional, and Villegas, Alejandro, additional

Published
2012
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34. The opto-mechanical design of HARMONI: a first light integral field spectrograph for the E-ELT

Author

Thatte, Niranjan A., primary, Tecza, Mathias, additional, Freeman, David, additional, Gallie, Angus M., additional, Montgomery, David, additional, Clarke, Fraser, additional, Fragoso-Lopez, Ana Belén, additional, Fuentes, Javier, additional, Gago, Fernando, additional, Garcia, Adolfo, additional, Gracia, Felix, additional, Kosmalski, Johan, additional, Lynn, James, additional, Sosa, Dario, additional, Arribas, Santiago, additional, Bacon, Roland, additional, Davies, Roger L., additional, Fusco, Thierry, additional, Lunney, David, additional, Mediavilla, Evencio, additional, Remillieux, Alban, additional, and Schnetler, Hermine, additional

Published
2012
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35. HARMONI: a single-field wide-band integral-field spectrograph for the European ELT

Author

Thatte, Niranjan, primary, Tecza, Mathias, additional, Clarke, Fraser, additional, Davies, Roger L., additional, Remillieux, Alban, additional, Bacon, Roland, additional, Lunney, David, additional, Arribas, Santiago, additional, Mediavilla, Evencio, additional, Gago, Fernando, additional, Bezawada, Naidu, additional, Ferruit, Pierre, additional, Fragoso, Ana, additional, Freeman, David, additional, Fuentes, Javier, additional, Fusco, Thierry, additional, Gallie, Angus, additional, Garcia, Adolfo, additional, Goodsall, Timothy, additional, Gracia, Felix, additional, Jarno, Aurelien, additional, Kosmalski, Johan, additional, Lynn, James, additional, McLay, Stuart, additional, Montgomery, David, additional, Pecontal, Arlette, additional, Schnetler, Hermine, additional, Smith, Harry, additional, Sosa, Dario, additional, Battaglia, Giuseppina, additional, Bowles, Neil, additional, Colina, Luis, additional, Emsellem, Eric, additional, Garcia-Perez, Ana, additional, Gladysz, Szymon, additional, Hook, Isobel, additional, Irwin, Patrick, additional, Jarvis, Matt, additional, Kennicutt, Robert, additional, Levan, Andrew, additional, Longmore, Andy, additional, Magorrian, John, additional, McCaughrean, Mark, additional, Origlia, Livia, additional, Rebolo, Rafael, additional, Rigopoulou, Dimitra, additional, Ryan, Sean, additional, Swinbank, Mark, additional, Tanvir, Nial, additional, Tolstoy, Eline, additional, and Verma, Aprajita, additional

Published
2010
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38. FPGA adaptive optics system test bench

Author

Rodriguez-Ramos, Luis F., primary, Viera, Teodora, additional, Gigante, Jose V., additional, Gago, Fernando, additional, Herrera, Guillermo, additional, Alonso, Angel, additional, and Descharmes, Nicolas, additional

Published
2005
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39. EMIR electronics and mechanism control

Author

Gago, Fernando, primary, Diaz, Jose J., additional, Redondo, Pablo, additional, Gonzalez, Carlos, additional, Beigbeder, Francis, additional, Chapon, Yvan, additional, Garzon, Francisco, additional, and Patron, Jesus, additional

Published
2004
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40. EMIR: the GTC NIR multi-object imager-spectrograph

Author

Garzon, Francisco, primary, Abreu, David, additional, Barrera, Sonia, additional, Correa, Santiago, additional, Diaz, Jose J., additional, Fragoso, Ana B., additional, Fuentes, F. J., additional, Gago, Fernando, additional, Gonzalez, Carlos, additional, Lopez, Pablo, additional, Manescau, Antonio, additional, Patron, Jesus, additional, Perez, Jaime, additional, Redondo, Pablo, additional, Restrepo, Rene, additional, Sanchez, Vicente, additional, and Villegas, Alejandro, additional

Published
2004
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42. EMIR: the GTC NIR multiobject imager-spectrograph

Author

Garzon, Francisco, primary, Barrera, S., additional, Correa, Santiago, additional, Diaz-Garcia, Jose J., additional, Fragoso-Lopez, Ana B., additional, Fuentes, F. Javier, additional, Gago, Fernando, additional, Lopez-Ruiz, Jose-Carlos, additional, Manescau, Antonio, additional, Patron, Jesus, additional, Perez-Espinos, Jaime, additional, Sanchez de la Rosa, Vicente, additional, Villegas, Alejandro, additional, and Redondo, Pablo, additional

Published
2003
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43. EMIR SOFTWARE: AN OVERVIEW

Author

Lpez-Ruiz, Jos‰ C., primary, Daz, Jose J., additional, Gago, Fernando, additional, Garzn, Francisco, additional, Patrn, Jes”s, additional, Pell, Roser, additional, and Gallego, Jes”s, additional

Published
2002
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44. Design and performance of the ESA Optical Ground Station

Author

Reyes Garcia-Talavera, Marcos, primary, Rodriguez, Jose A., additional, Viera, Teodora, additional, Moreno-Arce, Heidi, additional, Rasilla, Jose L., additional, Gago, Fernando, additional, Rodriguez, Luis F., additional, Gomez, Panchita, additional, and Ballesteros Ramirez, Ezequiel, additional

Published
2002
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49. The EMIR optical system

Author

Manescau, Antonio, primary, Fragoso-Lopez, Ana B., additional, Balcells, Marc, additional, Ballester Lluch, Jose A., additional, Correa, Santiago, additional, Diaz-Garcia, Jose J., additional, Fuentes, F. Javier, additional, Gago, Fernando, additional, Garzon, Francisco, additional, Lopez-Ruiz, Jose-Carlos, additional, Patron, Jesus, additional, and Perez-Espinos, Jaime, additional

Published
2002
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