1. Effect of manual OCTA segmentation correction to improve image quality and visibility of choroidal neovascularization in AMD
- Author
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Deussen, Daniel N, Heinke, Anna, Elsner, Wyatt, Galang, Carlo Miguel B, Kalaw, Fritz Gerald P, Warter, Alexandra, Bartsch, Dirk-Uwe, Cheng, Lingyun, and Freeman, William R
- Subjects
Biomedical and Clinical Sciences ,Ophthalmology and Optometry ,Neurosciences ,Macular Degeneration ,Eye Disease and Disorders of Vision ,Biomedical Imaging ,Neurodegenerative ,Aging ,Bioengineering ,Eye ,Humans ,Choroidal Neovascularization ,Tomography ,Optical Coherence ,Female ,Male ,Retrospective Studies ,Aged ,Aged ,80 and over ,Image Processing ,Computer-Assisted ,Middle Aged ,Fluorescein Angiography - Abstract
In this retrospective case series on neovascular age-related macular degeneration (nAMD), we aimed to improve Choroidal Neovascularization (CNV) visualization in Optical Coherence Tomography Angiography (OCTA) scans by addressing segmentation errors. Out of 198 eyes, 73 OCTA scans required manual segmentation correction. We compared uncorrected scans to those with minimal (2 corrections), moderate (10 corrections), and detailed (50 corrections) efforts targeting falsely segmented Bruch's Membrane (BM). Results showed that 55% of corrected OCTAs exhibited improved quality after manual correction. Notably, minimal correction (2 scans) already led to significant improvements, with additional corrections (10 or 50) not further enhancing expert grading. Reduced background noise and improved CNV identification were observed, with the most substantial improvement after two corrections compared to baseline uncorrected images. In conclusion, our approach of correcting segmentation errors effectively enhances image quality in OCTA scans of nAMD. This study demonstrates the efficacy of the method, with 55% of resegmented OCTA images exhibiting enhanced quality, leading to a notable increase in the proportion of high-quality images from 63 to 83%.
- Published
- 2024