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3. Neurological hypertensive emergencies: Correlation of blood pressure values with in-hospital outcomes in ischemic stroke

Author

Giani, V, Valobra, T, Capsoni, N, Galasso, M, De Censi, L, Ferretti, C, Sultana, A, Giacalone, A, Garofani, I, Bombelli, M, Ceresa, C, Gheda, S, Agostoni, E, Galbiati, F, Giannattasio, C, Maloberti, A, Giani, Valentina, Valobra, Tommaso, Capsoni, Nicolò, Galasso, Michele, De Censi, Lorenzo, Ferretti, Cecilia, Sultana, Andrea, Giacalone, Annalisa, Garofani, Ilaria, Bombelli, Michele, Ceresa, Chiara, Gheda, Silvia, Agostoni, Elio Clemente, Galbiati, Filippo, Giannattasio, Cristina, Maloberti, Alessandro, Giani, V, Valobra, T, Capsoni, N, Galasso, M, De Censi, L, Ferretti, C, Sultana, A, Giacalone, A, Garofani, I, Bombelli, M, Ceresa, C, Gheda, S, Agostoni, E, Galbiati, F, Giannattasio, C, Maloberti, A, Giani, Valentina, Valobra, Tommaso, Capsoni, Nicolò, Galasso, Michele, De Censi, Lorenzo, Ferretti, Cecilia, Sultana, Andrea, Giacalone, Annalisa, Garofani, Ilaria, Bombelli, Michele, Ceresa, Chiara, Gheda, Silvia, Agostoni, Elio Clemente, Galbiati, Filippo, Giannattasio, Cristina, and Maloberti, Alessandro

Abstract

Background: Few certainties exist regarding optimal management of Blood Pressure (BP) in the very first hours after an ischemic stroke and many questions remain still unanswered. Our work aimed to evaluate the role of BP and its trend as possible determinants of in-hospital mortality (primary outcome), discharge disabilities and hospitalization length (secondary outcomes) in ischemic stroke patients presented with Hypertensive Emergencies (HE). Methods: We retrospectively evaluated patients presented to Niguarda Hospital, Emergency Department (ED), from 2015 to 2017 with a neurological ischemic HE. BP at ED presentation (T0), its management in ED (T1) and its values at the stroke unit admission (T2) were evaluated. Results: 267 patients were included (0.13 % of all ED accesses and 17.9 % of all ischemic strokes). In the whole population, BP values were not associated with in-hospital mortality while T0 and T2 SBP result were associated to discharge disability and hospitalization length. In pre-specified subgroup analysis these associations were confirmed only in untreated subjects (not anti-hypertensive nor thrombolysis). In fact, no significant relationship can be found between BP values and any secondary outcome in thrombolysis and anti-hypertensive treated patients. Conclusions: BP values and its management can not be related to in-hospital mortality in stroke patients, presented with HE, while they are associated to discharge disability and hospitalization length. In subgroup analysis, results were confirmed only in untreated (not anti-hypertensive therapies nor thrombolytic).

Published
2024

5. EFFECT OF ANTI-PCSK9 ANTIBODIES ON ARTERY STRUCTURE AND FUNCTION: THE NIGUARDA HOSPITAL COHORT

Author

Maloberti, A, Toscani, G, Busti, A, Tognola, C, Intravaia, R, De Censi, L, Galasso, M, Daus, F, Giani, V, Gualini, E, Garofani, I, Riccio, A, Biolcati, M, Fabbri, S, Algeri, M, Merlini, P, Giannattasio, C, Morelli, M, Maloberti, Alessandro, Toscani, Giorgio, Busti, Andrea, Tognola, Chiara, Intravaia, Rita Cristina Mi, De Censi, Lorenzo, Galasso, Michele, Daus, Franesca, Giani, Valentina, Gualini, Elena, Garofani, Ilaria, Riccio, Alfonso, Biolcati, Marco, Fabbri, Saverio, Algeri, Michela, Merlini, Piera, Giannattasio, Cristina, Morelli, Martina, Maloberti, A, Toscani, G, Busti, A, Tognola, C, Intravaia, R, De Censi, L, Galasso, M, Daus, F, Giani, V, Gualini, E, Garofani, I, Riccio, A, Biolcati, M, Fabbri, S, Algeri, M, Merlini, P, Giannattasio, C, Morelli, M, Maloberti, Alessandro, Toscani, Giorgio, Busti, Andrea, Tognola, Chiara, Intravaia, Rita Cristina Mi, De Censi, Lorenzo, Galasso, Michele, Daus, Franesca, Giani, Valentina, Gualini, Elena, Garofani, Ilaria, Riccio, Alfonso, Biolcati, Marco, Fabbri, Saverio, Algeri, Michela, Merlini, Piera, Giannattasio, Cristina, and Morelli, Martina

Published
2024

6. HYPERTENSIVE EMERGENCIES AND URGENCIES: ADHERENCE TO GUIDELIENS AND RELATIONSHIP BETWEEN BLOOD PRESSURE MANAGEMENT AND IN-HOSPITAL MORTALITY

Author

Maloberti, A, Valobra, T, Giani, V, Garofani, I, De Censi, L, Galasso, M, Colombo, V, Menna, A, Giacalone, A, Ferretti, C, Sultana, A, Gheda, S, Capsoni, N, Galbiati, F, Bombelli, M, Giannattasio, C, Maloberti, Alessandro, Valobra, Tommaso, Giani, Valentina, Garofani, Ilaria, De Censi, Lorenzo, Galasso, Michele, Colombo, Valentina, Menna, Alessandro, Annalisa, Giacalone, Ferretti, Cecilia, Sultana, Andrea, Gheda, Silvia, Capsoni, Nicolò, Galbiati, Filippo, Bombelli, Michele, Giannattasio, Cristina, Maloberti, A, Valobra, T, Giani, V, Garofani, I, De Censi, L, Galasso, M, Colombo, V, Menna, A, Giacalone, A, Ferretti, C, Sultana, A, Gheda, S, Capsoni, N, Galbiati, F, Bombelli, M, Giannattasio, C, Maloberti, Alessandro, Valobra, Tommaso, Giani, Valentina, Garofani, Ilaria, De Censi, Lorenzo, Galasso, Michele, Colombo, Valentina, Menna, Alessandro, Annalisa, Giacalone, Ferretti, Cecilia, Sultana, Andrea, Gheda, Silvia, Capsoni, Nicolò, Galbiati, Filippo, Bombelli, Michele, and Giannattasio, Cristina

Published
2024

8. Bi-caval valve implantation to palliate symptoms in a case of massive tricuspid regurgitation

Author

Galasso, M, Cartella, I, Soriano, F, Nava, S, Tavoletta, P, De Chiara, B, Oliva, F, Bruschi, G, Oreglia, J, Giannattasio, C, Mangieri, A, Montalto, C, Galasso M., Cartella I., Soriano F., Nava S., Tavoletta P., De Chiara B., Oliva F., Bruschi G., Oreglia J. A., Giannattasio C., Mangieri A., Montalto C., Galasso, M, Cartella, I, Soriano, F, Nava, S, Tavoletta, P, De Chiara, B, Oliva, F, Bruschi, G, Oreglia, J, Giannattasio, C, Mangieri, A, Montalto, C, Galasso M., Cartella I., Soriano F., Nava S., Tavoletta P., De Chiara B., Oliva F., Bruschi G., Oreglia J. A., Giannattasio C., Mangieri A., and Montalto C.

Abstract

Severe tricuspid regurgitation is associated with the occurrence of right failure and increased morbidity and mortality. Transcatheter heterotopic bi-caval valve implantation might offer symptom relief in these patients that are often at prohibitive surgical risk.

Published
2023

14. C84 OUTCOME AND MORPHO–FUNCTIONAL CHANGES ON CARDIAC MAGNETIC RESONANCE IN PATIENT WITH ACUTE MYOCARDITIS FOLLOWING MRNA COVID 19 VACCINATION

Author

Palazzini, M, primary, Ammirati, E, additional, Lupi, L, additional, Garascia, A, additional, Gentile, P, additional, Pedrotti, P, additional, Giannattasio, C, additional, Ciabatti, M, additional, Rossi, V, additional, Ruschitzka, F, additional, Uribarri, A, additional, Vecchio, C, additional, Nassiacos, D, additional, Cereda, A, additional, Tumminiello, G, additional, Piriou, N, additional, Stucchi, M, additional, Peretto, G, additional, Galasso, M, additional, Sala, S, additional, Camici, P, additional, Huang, F, additional, Ianni, U, additional, Procopio, A, additional, Saponara, G, additional, Cimaglia, P, additional, Tomasoni, D, additional, Moroni, F, additional, Turco, A, additional, Di Tano, G, additional, Bollano, E, additional, Moro, C, additional, Abbate, A, additional, Dalla Bona, R, additional, Porto, I, additional, Carugo, S, additional, Campodonico, J, additional, Pontone, G, additional, Grosu, A, additional, Adamo, M, additional, Salamanca, J, additional, Ozieransky, K, additional, Sardo Infirri, L, additional, Cannatà, A, additional, Adler, E, additional, Sinagra, G, additional, Potena, L, additional, Foà, A, additional, Metra, M, additional, and Pieroni, M, additional

Published
2023
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16. Persistent ST-segment elevation with elevated myocardial necrosis markers: A case of myocardial contusion [Sopraslivellamento persistente del tratto ST con marcatori di miocardiocitonecrosi elevati: un caso di contusione cardiaca]

Author

Stucchi, M, Galasso, M, De Censi, L, Cirò, A, Pedrotti, P, Giannattasio, C, Stucchi, M, Galasso, M, De Censi, L, Cirò, A, Pedrotti, P, and Giannattasio, C

Abstract

Myocardial contusion is a rare and potentially fatal complication of chest trauma. There is no unique definition for this entity: some authors define myocardial contusion as a mild increase in cardiac biomarkers in the context of chest trauma, while for others the diagnosis requires evidence of pathologic findings at cardiac imaging. Consequently, the real incidence of myocardial contusion remains unknown, varying in reports between 8% and 71%. We describe a case of cardiac contusion secondary to a low-energy blunt chest trauma, manifesting as persistent ST-elevation associated with elevation of myocardial necrosis markers, with consequent myocardial stunning of the right ventricular free wall. As there is no consensus regarding the diagnostic pathway, it is essential to integrate first-level exams (ECG and laboratory findings) with cardiac magnetic resonance imaging, to define the presence of cardiac contusion and its extent, particularly if the echocardiographic data are unconclusive.

Published
2023

17. Natural history and clinical burden of moderate aortic stenosis: a systematic review and explorative meta-analysis

Author

Morelli, M, Galasso, M, Esposito, G, Soriano, F, Nava, S, Da Pozzo, C, Bossi, I, Piccaluga, E, Bruschi, G, Maloberti, A, Oliva, F, Oreglia, J, Giannattasio, C, Montalto, C, Morelli, Martina, Galasso, Michele, Esposito, Giuseppe, Soriano, Francesco Stefano, Nava, Stefano, Da Pozzo, Caterina, Bossi, Irene, Piccaluga, Emanuela, Bruschi, Giuseppe, Maloberti, Alessandro, Oliva, Fabrizio, Oreglia, Jacopo Andrea, Giannattasio, Cristina, Montalto, Claudio, Morelli, M, Galasso, M, Esposito, G, Soriano, F, Nava, S, Da Pozzo, C, Bossi, I, Piccaluga, E, Bruschi, G, Maloberti, A, Oliva, F, Oreglia, J, Giannattasio, C, Montalto, C, Morelli, Martina, Galasso, Michele, Esposito, Giuseppe, Soriano, Francesco Stefano, Nava, Stefano, Da Pozzo, Caterina, Bossi, Irene, Piccaluga, Emanuela, Bruschi, Giuseppe, Maloberti, Alessandro, Oliva, Fabrizio, Oreglia, Jacopo Andrea, Giannattasio, Cristina, and Montalto, Claudio

Abstract

Aims: The mortality risk of patients with moderate aortic stenosis is not well known, but recent studies suggested that it might negatively affect prognosis. We aimed to assess the natural history and clinical burden of moderate aortic stenosis and to investigate the interaction of patients' baseline characteristics with prognosis. Methods: Systematic research was conducted on PubMed. The inclusion criteria were inclusion of patients with moderate aortic stenosis; and report of the survival at 1-year follow-up (minimum). Incidence ratios related to all-cause mortality in patients and controls of each study were estimated and then pooled using a fixed effects model. All patients with mild aortic stenosis or without aortic stenosis were considered controls. Meta-regression analysis was performed to assess the impact of left ventricular ejection fraction and age on the prognosis of patients with moderate aortic stenosis. Results: Fifteen studies and 11 596 patients with moderate aortic stenosis were included. All-cause mortality was significantly higher among patients with moderate aortic stenosis than in controls in all timeframes analysed (all P < 0.0001). Left ventricular ejection fraction and sex did not significantly impact on the prognosis of patients with moderate aortic stenosis (P = 0.4584 and P = 0.5792), while increasing age showed a significant interaction with mortality (estimate = 0.0067; 95% confidence interval: 0.0007-0.0127; P = 0.0323). Conclusion: Moderate aortic stenosis is associated with reduced survival. Further studies are necessary to confirm the prognostic impact of this valvulopathy and the possible benefit of aortic valve replacement.

Published
2023

18. Outcome and Morphofunctional Changes on Cardiac Magnetic Resonance in Patients With Acute Myocarditis Following mRNA COVID-19 Vaccination

Author

Ammirati, E, Lupi, L, Palazzini, M, Ciabatti, M, Rossi, V, Gentile, P, Uribarri, A, Vecchio, C, Nassiacos, D, Cereda, A, Conca, C, Tumminello, G, Piriou, N, Lelarge, C, Pedrotti, P, Stucchi, M, Peretto, G, Galasso, M, Huang, F, Ianni, U, Procopio, A, Saponara, G, Cimaglia, P, Tomasoni, D, Moroni, F, Turco, A, Sala, S, Di Tano, G, Bollano, E, Moro, C, Abbate, A, Della Bona, R, Porto, I, Carugo, S, Campodonico, J, Pontone, G, Grosu, A, Bolognese, L, Salamanca, J, Diez-Villanueva, P, Ozieranski, K, Tyminska, A, Sardo Infirri, L, Bromage, D, Cannatà, A, Hong, K, Adamo, M, Quattrocchi, G, Foà, A, Potena, L, Garascia, A, Giannattasio, C, Adler, E, Sinagra, G, Ruschitzka, F, Camici, P, Metra, M, Pieroni, M, Ammirati, Enrico, Lupi, Laura, Palazzini, Matteo, Ciabatti, Michele, Rossi, Valentina A, Gentile, Piero, Uribarri, Aitor, Vecchio, Chiara R, Nassiacos, Daniele, Cereda, Alberto, Conca, Cristina, Tumminello, Gabriele, Piriou, Nicolas, Lelarge, Coline, Pedrotti, Patrizia, Stucchi, Miriam, Peretto, Giovanni, Galasso, Michele, Huang, Florent, Ianni, Umberto, Procopio, Antonio, Saponara, Gianluigi, Cimaglia, Paolo, Tomasoni, Daniela, Moroni, Francesco, Turco, Annalisa, Sala, Simone, Di Tano, Giuseppe, Bollano, Entela, Moro, Claudio, Abbate, Antonio, Della Bona, Roberta, Porto, Italo, Carugo, Stefano, Campodonico, Jeness, Pontone, Gianluca, Grosu, Aurelia, Bolognese, Leonardo, Salamanca, Jorge, Diez-Villanueva, Pablo, Ozieranski, Krzysztof, Tyminska, Agata, Sardo Infirri, Loren, Bromage, Daniel, Cannatà, Antonio, Hong, Kimberly N, Adamo, Marianna, Quattrocchi, Giuseppina, Foà, Alberto, Potena, Luciano, Garascia, Andrea, Giannattasio, Cristina, Adler, Eric D, Sinagra, Gianfranco, Ruschitzka, Frank, Camici, Paolo G, Metra, Marco, Pieroni, Maurizio, Ammirati, E, Lupi, L, Palazzini, M, Ciabatti, M, Rossi, V, Gentile, P, Uribarri, A, Vecchio, C, Nassiacos, D, Cereda, A, Conca, C, Tumminello, G, Piriou, N, Lelarge, C, Pedrotti, P, Stucchi, M, Peretto, G, Galasso, M, Huang, F, Ianni, U, Procopio, A, Saponara, G, Cimaglia, P, Tomasoni, D, Moroni, F, Turco, A, Sala, S, Di Tano, G, Bollano, E, Moro, C, Abbate, A, Della Bona, R, Porto, I, Carugo, S, Campodonico, J, Pontone, G, Grosu, A, Bolognese, L, Salamanca, J, Diez-Villanueva, P, Ozieranski, K, Tyminska, A, Sardo Infirri, L, Bromage, D, Cannatà, A, Hong, K, Adamo, M, Quattrocchi, G, Foà, A, Potena, L, Garascia, A, Giannattasio, C, Adler, E, Sinagra, G, Ruschitzka, F, Camici, P, Metra, M, Pieroni, M, Ammirati, Enrico, Lupi, Laura, Palazzini, Matteo, Ciabatti, Michele, Rossi, Valentina A, Gentile, Piero, Uribarri, Aitor, Vecchio, Chiara R, Nassiacos, Daniele, Cereda, Alberto, Conca, Cristina, Tumminello, Gabriele, Piriou, Nicolas, Lelarge, Coline, Pedrotti, Patrizia, Stucchi, Miriam, Peretto, Giovanni, Galasso, Michele, Huang, Florent, Ianni, Umberto, Procopio, Antonio, Saponara, Gianluigi, Cimaglia, Paolo, Tomasoni, Daniela, Moroni, Francesco, Turco, Annalisa, Sala, Simone, Di Tano, Giuseppe, Bollano, Entela, Moro, Claudio, Abbate, Antonio, Della Bona, Roberta, Porto, Italo, Carugo, Stefano, Campodonico, Jeness, Pontone, Gianluca, Grosu, Aurelia, Bolognese, Leonardo, Salamanca, Jorge, Diez-Villanueva, Pablo, Ozieranski, Krzysztof, Tyminska, Agata, Sardo Infirri, Loren, Bromage, Daniel, Cannatà, Antonio, Hong, Kimberly N, Adamo, Marianna, Quattrocchi, Giuseppina, Foà, Alberto, Potena, Luciano, Garascia, Andrea, Giannattasio, Cristina, Adler, Eric D, Sinagra, Gianfranco, Ruschitzka, Frank, Camici, Paolo G, Metra, Marco, and Pieroni, Maurizio

Published
2023

19. Lipoprotein(a): Cardiovascular Disease, Aortic Stenosis and New Therapeutic Option

Author

Maloberti, A, Fabbri, S, Colombo, V, Gualini, E, Monticelli, M, Daus, F, Busti, A, Galasso, M, De Censi, L, Algeri, M, Merlini, P, Giannattasio, C, Maloberti, Alessandro, Fabbri, Saverio, Colombo, Valentina, Gualini, Elena, Monticelli, Massimiliano, Daus, Francesca, Busti, Andrea, Galasso, Michele, De Censi, Lorenzo, Algeri, Michela, Merlini, Piera Angelica, Giannattasio, Cristina, Maloberti, A, Fabbri, S, Colombo, V, Gualini, E, Monticelli, M, Daus, F, Busti, A, Galasso, M, De Censi, L, Algeri, M, Merlini, P, Giannattasio, C, Maloberti, Alessandro, Fabbri, Saverio, Colombo, Valentina, Gualini, Elena, Monticelli, Massimiliano, Daus, Francesca, Busti, Andrea, Galasso, Michele, De Censi, Lorenzo, Algeri, Michela, Merlini, Piera Angelica, and Giannattasio, Cristina

Abstract

Atherosclerosis is a chronic and progressive inflammatory process beginning early in life with late clinical manifestation. This slow pathological trend underlines the importance to early identify high-risk patients and to treat intensively risk factors to prevent the onset and/or the progression of atherosclerotic lesions. In addition to the common Cardiovascular (CV) risk factors, new markers able to increase the risk of CV disease have been identified. Among them, high levels of Lipoprotein(a)—Lp(a)—lead to very high risk of future CV diseases; this relationship has been well demonstrated in epidemiological, mendelian randomization and genome-wide association studies as well as in meta-analyses. Recently, new aspects have been identified, such as its association with aortic stenosis. Although till recent years it has been considered an unmodifiable risk factor, specific drugs have been developed with a strong efficacy in reducing the circulating levels of Lp(a) and their capacity to reduce subsequent CV events is under testing in ongoing trials. In this paper we will review all these aspects: from the synthesis, clearance and measurement of Lp(a), through the findings that examine its association with CV diseases and aortic stenosis to the new therapeutic options that will be available in the next years.

Published
2023

22. P604: CATALASE EXPRESSION IN LEUKEMIA CELLS IS CONTROLLED BY GENETIC AND EPIGENETIC MECHANISMS

Author

Galasso, M., primary, Dalla Pozza, E., additional, Chignola, R., additional, Gambino, S., additional, Cavallini, C., additional, Pilatone, A., additional, Quaglia, F. M., additional, Lovato, O., additional, Dando, I., additional, Malpeli, G., additional, Krampera, M., additional, Donadelli, M., additional, Romanelli, M. G., additional, and Scupoli, M. T., additional

Published
2022
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23. Effect of Magnetic Impurities on Superconductivity in LaH10

Author

Semenok, D. V., Troyan, I. A., Sadakov, A. V., Zhou, D., Galasso, M., Kvashnin, A. G., Ivanova, A. G., Kruglov, I. A., Bykov, A. A., Terent'Ev, K. Y., Cherepakhin, A. V., Sobolevskiy, O. A., Pervakov, K. S., Seregin, A. Y., (0000-0002-0938-8537) Helm, T., Förster, T., Grockowiak, A. D., Tozer, S. W., Nakamoto, Y., Shimizu, K., Pudalov, V. M., Lyubutin, I. S., Oganov, A. R., Semenok, D. V., Troyan, I. A., Sadakov, A. V., Zhou, D., Galasso, M., Kvashnin, A. G., Ivanova, A. G., Kruglov, I. A., Bykov, A. A., Terent'Ev, K. Y., Cherepakhin, A. V., Sobolevskiy, O. A., Pervakov, K. S., Seregin, A. Y., (0000-0002-0938-8537) Helm, T., Förster, T., Grockowiak, A. D., Tozer, S. W., Nakamoto, Y., Shimizu, K., Pudalov, V. M., Lyubutin, I. S., and Oganov, A. R.

Abstract

Polyhydrides are a novel class of superconducting materials with extremely high critical parameters, which is very promising for sensor applications. On the other hand, a complete experimental study of the best so far known superconductor, lanthanum superhydride LaH10, encounters a serious complication because of the large upper critical magnetic field Hc2(0), exceeding 120–160 T. It is found that partial replacement of La atoms by magnetic Nd atoms results in significant suppression of superconductivity in LaH10: each at% of Nd causes a decrease in Tc by 10–11 K, helping to control the critical parameters of this compound. Strong pulsed magnetic fields up to 68 T are used to study the Hall effect, magnetoresistance, and the magnetic phase diagram of ternary metal polyhydrides for the first time. Surprisingly, (La,Nd)H10 demonstrates completely linear Hc2(T) ∝ |T – Tc|, which calls into question the applicability of the Werthamer–Helfand–Hohenberg model for polyhydrides. The suppression of superconductivity in LaH10 by magnetic Nd atoms and the robustness of Tc with respect to nonmagnetic impurities (e.g., Y, Al, C) under Anderson’s theorem gives new experimental evidence of the isotropic (s-wave) character of conventional electron–phonon pairing in lanthanum decahydride.

Published
2022

24. Treatment of Cytomegalovirus in Human Donor Lungs with a Novel Chemokine-Based Immunotoxin during Ex Vivo Lung Perfusion Prevents Viral Reactivation

Author

VP Ribeiro, R., primary, Ku, T., additional, Ferreira, V. H, additional, Pires, L., additional, Michaelsen, V. S, additional, Wang, A., additional, Ali, A., additional, Moshkelgosha, S., additional, Galasso, M., additional, Gazzalle, A., additional, Sinclair, J., additional, Kledal, T., additional, Liu, M., additional, Keshavjee, S., additional, Singer, L. G, additional, Kumar, D., additional, Humar, A., additional, and Cypel, M., additional

Published
2021
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25. Ventricular arrhythmias in patients with functional mitral regurgitation and implantable cardiac devices: implications of mitral valve repair with Mitraclip

Author

Benito Gonzalez, T, primary, Freixa, X, additional, Godino, C, additional, Taramasso, M, additional, Estevez-Loureiro, R, additional, Pascual, I, additional, Serrador, A, additional, Nombela, L, additional, Grande, D, additional, Cruz, I, additional, San Antonio, R, additional, Galasso, M, additional, Gavazzoni, M, additional, Portoles, A, additional, and Fernandez-Vazquez, F, additional

Published
2020
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26. Evaluating the Influence of Peep-Induced Alveolar Recruitment on Lung Injury During VV-ECMO for ARDS

Author

Del Sorbo, L., primary, Gomes, B., additional, Ribeiro, R., additional, Ramadan, K., additional, Galasso, M., additional, Ali, A., additional, Watanabe, Y., additional, Paradiso, E., additional, Meineri, M., additional, Chan, H., additional, Qaqish, R., additional, Zhang, Y., additional, Hwang, D., additional, Slutsky, A.S., additional, Fan, E., additional, Liu, M., additional, Keshavjee, S., additional, and Cypel, M., additional

Published
2020
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27. Gaseous Nitric Oxide (gNO) as a Potential Antimicrobial Therapy during Ex Vivo Lung Perfusion: An Efficacy and Safety Study

Author

Michaelsen, V.S., primary, VP Ribeiro, R., additional, Wang, A., additional, Price, C., additional, Wannberg, B., additional, Zhang, Y., additional, Pires, L., additional, del Sorbo, L., additional, Ramadan, K., additional, Gomes, B., additional, Galasso, M., additional, Brambate, E., additional, Gazzalle, A., additional, Liu, M., additional, Keshavjee, S., additional, and Cypel, M., additional

Published
2020
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29. Targeting Latent Human Cytomegalovirus (CMV) with a Novel Fusion Toxin Protein during Ex Vivo Lung Perfusion

Author

VP Ribeiro, R., primary, Ku, T., additional, Ferreira, V.H., additional, Galasso, M., additional, Moshkelgosha, S., additional, Michaelsen, V., additional, Wang, A., additional, Ali, A., additional, Ramadan, K., additional, Gomes, B.M., additional, Pires, L., additional, Gokhale, H., additional, Gazzalle, A., additional, Sinclair, J., additional, Kledal, T., additional, Liu, M., additional, Keshavjee, S., additional, Humar, A., additional, and Cypel, M., additional

Published
2020
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32. miR-129-5p: A key factor and therapeutic target in amyotrophic lateral sclerosis

Author

Loffreda, A, Nizzardo, M, Arosio, A, Ruepp, M, Calogero, R, Volinia, S, Galasso, M, Bendotti, C, Ferrarese, C, Lunetta, C, Rizzuti, M, Ronchi, A, Mühlemann, O, Tremolizzo, L, Corti, S, Barabino, S, Loffreda, Alessia, Nizzardo, Monica, Arosio, Alessandro, Ruepp, Marc-David, Calogero, Raffaele A, Volinia, Stefano, Galasso, Marco, Bendotti, Caterina, Ferrarese, Carlo, Lunetta, Christian, Rizzuti, Mafalda, Ronchi, Antonella, Mühlemann, Oliver, Tremolizzo, Lucio, Corti, Stefania, Barabino, Silvia M L, Loffreda, A, Nizzardo, M, Arosio, A, Ruepp, M, Calogero, R, Volinia, S, Galasso, M, Bendotti, C, Ferrarese, C, Lunetta, C, Rizzuti, M, Ronchi, A, Mühlemann, O, Tremolizzo, L, Corti, S, Barabino, S, Loffreda, Alessia, Nizzardo, Monica, Arosio, Alessandro, Ruepp, Marc-David, Calogero, Raffaele A, Volinia, Stefano, Galasso, Marco, Bendotti, Caterina, Ferrarese, Carlo, Lunetta, Christian, Rizzuti, Mafalda, Ronchi, Antonella, Mühlemann, Oliver, Tremolizzo, Lucio, Corti, Stefania, and Barabino, Silvia M L

Abstract

Amyotrophic lateral sclerosis (ALS) is a relentless and fatal neurological disease characterized by the selective degeneration of motor neurons. No effective therapy is available for this disease. Several lines of evidence indicate that alteration of RNA metabolism, including microRNA (miRNA) processing, is a relevant pathogenetic factor and a possible therapeutic target for ALS. Here, we showed that the abundance of components in the miRNA processing machinery is altered in a SOD1-linked cellular model, suggesting consequent dysregulation of miRNA biogenesis. Indeed, high-throughput sequencing of the small RNA fraction showed that among the altered miRNAs, miR-129-5p was increased in different models of SOD1-linked ALS and in peripheral blood cells of sporadic ALS patients. We demonstrated that miR-129-5p upregulation causes the downregulation of one of its targets: the RNA-binding protein ELAVL4/HuD. ELAVL4/HuD is predominantly expressed in neurons, where it controls several key neuronal mRNAs. Overexpression of pre-miR-129-1 inhibited neurite outgrowth and differentiation via HuD silencing in vitro, while its inhibition with an antagomir rescued the phenotype. Remarkably, we showed that administration of an antisense oligonucleotide (ASO) inhibitor of miR-129-5p to an ALS animal model, SOD1 (G93A) mice, result in a significant increase in survival and improved the neuromuscular phenotype in treated mice. These results identify miR-129-5p as a therapeutic target that is amenable to ASO modulation for the treatment of ALS patients.

Published
2020

33. Blood to skin recirculation of CD4+ memory T cells associates with cutaneous and systemic manifestations of psoriatic disease

Author

Diani, M, Galasso, M, Cozzi, C, Sgambelluri, F, Altomare, A, Cigni, C, Frigerio, E, Drago, L, Volinia, S, Granucci, F, Altomare, G, Reali, E, Diani M., Galasso M., Cozzi C., Sgambelluri F., Altomare A., Cigni C., Frigerio E., Drago L., Volinia S., Granucci F., Altomare G., Reali E., Diani, M, Galasso, M, Cozzi, C, Sgambelluri, F, Altomare, A, Cigni, C, Frigerio, E, Drago, L, Volinia, S, Granucci, F, Altomare, G, Reali, E, Diani M., Galasso M., Cozzi C., Sgambelluri F., Altomare A., Cigni C., Frigerio E., Drago L., Volinia S., Granucci F., Altomare G., and Reali E.

Abstract

Blood to skin recirculation could play a role in the pathogenesis of psoriasis. To investigate this possibility we dissected the phenotype of circulating T cells in psoriasis patients, calculated the correlation the clinical parameters of the disease and performed a parallel bioinformatics analysis of gene expression data in psoriatic skin. We found that circulating CCR6+ CD4+ TEM and TEFF cells significantly correlated with systemic inflammation. Conversely, the percentage of CXCR3+ CD4+ TEM cells negatively correlated with the severity of the cutaneous disease. Importantly CLA+ CD4+ TCM cells expressing CCR6+ or CCR4+ CXCR3+ negatively correlated with psoriasis severity suggesting recruitment to the skin compartment. This assumption was reinforced by gene expression data showing marked increase of CCR7 and CLA-encoding gene SELPLG expression in psoriatic skin and strong association of their expression. The data enlightens a role for CD4+ T cells trafficking between blood and skin in cutaneous and systemic manifestations of psoriasis.

Published
2017

35. Effect of PEEP-Induced Alveolar Recruitment on Lung Injury during Extracorporeal Membrane Oxygenation for ARDS

Author

Gomes, B.M., primary, Ribeiro, R.V., additional, Ramadan, K., additional, Galasso, M., additional, Ali, A., additional, Watanabe, Y., additional, Paradiso, E., additional, Meineri, M., additional, Chan, H., additional, Zhang, Y., additional, Hwang, D., additional, Slutsky, A., additional, Fan, E., additional, Liu, M., additional, Keshavjee, S., additional, Cypel, M., additional, and del Sorbo, L., additional

Published
2019
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36. Initial Experience with Non-Perfused Organ Donors for Lung Transplantation

Author

Watanabe, Y., primary, Healey, A., additional, Scott, M., additional, Lavery, S., additional, Johnson, K., additional, Mills, C., additional, Galasso, M., additional, Chen, M., additional, Yeung, J., additional, Donahoe, L., additional, Pierre, A., additional, de Perrot, M., additional, Yasufuku, K., additional, Waddell, T.K., additional, Keshavjee, S., additional, and Cypel, M., additional

Published
2019
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38. Transplantation of NAT+HCV Donor Lungs into Non-Infected Recipients Followed by Treatment with Sofosbuvir/Velpatasvir (S/V)

Author

Cypel, M., primary, Feld, J., additional, Singer, L.G., additional, Marks, N., additional, Bahinskaya, I., additional, Kuczynski, M., additional, Kumar, D., additional, Galasso, M., additional, Ribeiro, R., additional, Yeung, J., additional, Donahoe, L., additional, Pierre, A., additional, de Perrot, M., additional, Yasufuku, K., additional, Waddell, T.K., additional, Keshavjee, S., additional, and Humar, A., additional

Published
2019
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39. A Clinical Trial Evaluating the Effects of Ultra-Violet C treatment (UVC) during Ex Vivo Lung Perfusion (EVLP) as a Method of Inactivating Hepatitis C Infection in Donor Lungs

Author

Cypel, M., primary, Galasso, M., additional, Ribeiro, R., additional, Wilson, B., additional, Bagnato, V., additional, Kurachi, C., additional, Chen, M., additional, Kumar, D., additional, Waddell, T.K., additional, Singer, L.G., additional, Keshavjee, S., additional, Humar, A., additional, and Feld, J., additional

Published
2019
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46. Prone Positioning Attenuates Lung Injury During Warm Ischemia in a Large Animal Controlled Donation after Cardiac Death Model

Author

Watanabe, Y., primary, Galasso, M., additional, Watanabe, T., additional, Ali, A., additional, Chan, H.H., additional, Qaqish, R., additional, Summers, C., additional, Ramadan, K., additional, Ribeiro, R.V., additional, Zhang, Y., additional, Gazzalle, A., additional, Waddell, T.K., additional, Liu, M., additional, Keshavjee, S., additional, Del Sorbo, L., additional, and Cypel, M., additional

Published
2018
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47. Two-Day Lung Preservation Followed by Lung Transplantation in a Large Animal Model Using Novel Extracellular Oxygen Carrier

Author

Ali, A., primary, Watanabe, Y., additional, Galasso, M., additional, Stansfield, W., additional, Watanabe, T., additional, Ramandan, K., additional, Chen, M., additional, Ribeiro, R.P., additional, Gokhale, H., additional, Gazzalle, A., additional, Waddell, T., additional, Liu, M., additional, Keshavjee, S., additional, and Cypel, M., additional

Published
2018
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48. 43Hisian pacing with apical back-up on demand is safe and effective

Author

Zanon, F, primary, Marcantoni, L, additional, Pastore, G, additional, Baracca, E, additional, Picariello, C, additional, Lanza, D, additional, Giatti, S, additional, Aggio, S, additional, Carraro, M, additional, Conte, L, additional, D'elia, K, additional, Roncon, L, additional, Rinuncini, M, additional, and Galasso, M P, additional

Published
2018
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49. P1132LV lead apical placement could be the best option in selected patients candidate to CRT

Author

Zanon, F, primary, Marcantoni, L, additional, Baracca, E, additional, Pastore, G, additional, Giatti, S, additional, Aggio, S, additional, Picariello, C, additional, Lanza, D, additional, Roncon, L, additional, Noventa, F, additional, Conte, L, additional, Carraro, M, additional, Rinuncini, M, additional, Galasso, M P, additional, and D'elia, K, additional

Published
2018
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50. P1143MPP reduces the ventricular arrhythmias burden compared to standard biventricular pacing in CRT patients

Author

Zanon, F, primary, Marcantoni, L, additional, Baracca, E, additional, Pastore, G, additional, Giatti, S, additional, Aggio, S, additional, Picariello, C, additional, Lanza, D, additional, Roncon, L, additional, D'elia, K, additional, Noventa, F, additional, Carraro, M, additional, Rinuncini, M, additional, Galasso, M P, additional, and Conte, L, additional

Published
2018
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