Search

Your search keyword '"Galdiero F"' showing total 288 results
Start Over Author "Galdiero F"
288 results on '"Galdiero F"'

1. Biological Role of Tumor/Stromal CXCR4-CXCL12-CXCR7 in MITO16A/MaNGO-OV2 Advanced Ovarian Cancer Patients

Author

D'Alterio, C, Spina, A, Arenare, L, Chiodini, P, Napolitano, M, Galdiero, F, Portella, L, Simeon, V, Signoriello, S, Raspagliesi, F, Lorusso, D, Pisano, C, Colombo, N, Zannoni, G, Losito, N, De Cecio, R, Scognamiglio, G, Califano, D, Russo, D, Tuninetti, V, Piccirillo, M, Gargiulo, P, Perrone, F, Pignata, S, Scala, S, D'alterio C., Spina A., Arenare L., Chiodini P., Napolitano M., Galdiero F., Portella L., Simeon V., Signoriello S., Raspagliesi F., Lorusso D., Pisano C., Colombo N., Zannoni G. F., Losito N. S., De Cecio R., Scognamiglio G., Califano D., Russo D., Tuninetti V., Piccirillo M. C., Gargiulo P., Perrone F., Pignata S., Scala S., D'Alterio, C, Spina, A, Arenare, L, Chiodini, P, Napolitano, M, Galdiero, F, Portella, L, Simeon, V, Signoriello, S, Raspagliesi, F, Lorusso, D, Pisano, C, Colombo, N, Zannoni, G, Losito, N, De Cecio, R, Scognamiglio, G, Califano, D, Russo, D, Tuninetti, V, Piccirillo, M, Gargiulo, P, Perrone, F, Pignata, S, Scala, S, D'alterio C., Spina A., Arenare L., Chiodini P., Napolitano M., Galdiero F., Portella L., Simeon V., Signoriello S., Raspagliesi F., Lorusso D., Pisano C., Colombo N., Zannoni G. F., Losito N. S., De Cecio R., Scognamiglio G., Califano D., Russo D., Tuninetti V., Piccirillo M. C., Gargiulo P., Perrone F., Pignata S., and Scala S.

Abstract

This study investigated the prognostic role of the CXCR4-CXCL12-CXCR7 axis in advanced epithelial ovarian cancer (EOC) patients receiving first-line treatment within the MITO16A/MaNGO-OV2 phase-IV trial. CXCR4-CXCL12-CXCR7 expression was evaluated in the epithelial and stromal component of 308 EOC IHC-stained tumor samples. The statistical analysis focused on biomarkers’ expression, their association with other variables and prognostic value. Zero-inflated tests, shrinkage, bootstrap procedures, and multivariable models were applied. The majority of EOC (75.0%) expressed CXCR4 and CXCR7, 56.5% expressed the entire CXCR4-CXCL12-CXCR7 axis, while only 4.6% were negative for CXCL12 and its cognate receptors, in regard to the epithelial component. Stromal CXCL12 and CXCR7, expressed in 11.2% and 65.5%, respectively, were associated with the FIGO stage. High CXCL12 in epithelial cancer cells was associated with shorter progression-free and overall survival. However, after adjusting for overfitting due to best cut-off multiplicity testing, the significance was lost. This is a wide-ranging, prospective study in which CXCR4-CXCL12-CXCR7 were systematically evaluated in epithelial and stromal components, in selected stage III-IV EOC. Although CXCL12 was not prognostic, epithelial expression identified high-risk FIGO stage III patients for PFS. These data suggest that it might be worth studying the CXCL12 axis as a therapeutic target to improve treatment efficacy in EOC patients.

Published
2022

2. Abstracts

Author

Telenti, A., Marshall, W. F., Proper, J., Aksamit, A. J., Smith, T. F., Matthey, S., Nicholson, D., Ruhs, S., Alden, B., Knock, M., McLean, D. M., McKendall, R. R., Lairmore, M. D., Oas, J., McLinden, J., Stapelton, J., Ploplis, V., Rosen, E., Porter-Jordan, K., Rosenberg, E., Keiser, J., Garrett, C. T., Reyes, M. P., Meriwether, C., Moore, E. C., Philpot, D., Cohen, F., Riepenhoff-Talty, M., Uhnoo, I., Greenberg, H. B., Fisher, J. E., Chegas, P., Barrett, H., Li, P. K., Ogra, P. L., Littlewood, R. A., Sibau, L. E., Sherlock, C. H., Shimozuma, M., Miner, R. C., Epstein, W. L., Drew, W. L., Fukuyama, K., Siegel, C., Johnston, S., Subbarao, E. K., Waner, J. L., Walpita, P., Jalowayski, A., Mason, V., Chadwick, D., Connor, J. D., West, P. G., Baker, W. W., Wiedbrauk, D. L., Welch, K. M., Coffee, S. J., Taylor, A. F., Alexander, R. C., Al-Nakib, W., Yasin, S. R., Tyrrell, D. A. J., Zimmerman, S. J., Moses, E., Sofat, N., Bartholomew, W. R., Amsterdam, D., Gall, D., Reed, C., Crespi, V., Aquino, T. I., Clark, J., Tang, J., Colacino, J. M., Larsen, S. H., Forghani, B., Hurst, M., Chan, C., Dennis, J., Darai, G., Galdiero, F., Folgore, A., Tufano, M. A., Gill, M. J., Cassol, S. A., Gleaves, C. A., Lee, C. F., Rice, D. H., Wendt, S. F., Dobbs, D. R., Meyers, J. D., West, K., Herrmann, J. E., Bruns, M., Ennis, F. A., Khatib, R., Smith, F., Lindquester, G. J., Dambaugh, T., Allen, R., Pellett, P. E., Aarnaes, S. L., MacDonald, R. L., de la Maza, L. M., Peterson, E. M., de la Maza, Luis M., editor, and Peterson, Ellena M., editor

Published
1991
Full Text
View/download PDF

15. Interleukin-1 and interleukin-6 gene expression in human monocytes stimulated with Salmonella typhimurium porins

Author

Galdiero, M., Cipollaro L Ero, G., Giovanna DONNARUMMA, Marcatili, A., Galdiero, F., Galdiero, M, CIPOLLARO DE L'ERO, G, Donnarumma, Giovanna, Marcatili, A, and Galdiero, F.

Subjects
Salmonella typhimurium, Transcription, Genetic, Interleukin-6, Cell Culture Techniques, Porins, biochemical phenomena, metabolism, and nutrition, Blotting, Northern, Monocytes, inflammatory and immunological responses, Gene Expression Regulation, Protein Biosynthesis, bacteria, Humans, RNA, RNA, Messenger, Salmonella typhimurium porins, Research Article, Interleukin-1
Abstract

The aim of this study was to verify whether Salmonella typhimurium porins can affect the expression of interleukin-1 (IL-1) and interleukin-6 (IL-6) genes. Human monocytes were treated with porins, and total RNAs were analysed by Northern blotting to evaluate the expression of IL-1 alpha, IL-1 beta and IL-6 in both treated and untreated cell cultures. Porins induced a significant increase in IL-1 and IL-6 transcripts. This increase was related to the dose of porins, and it peaked 5 hr after treatment. The same results were obtained when polymyxin B was added to the porin preparation to eliminate eventual traces of lipopolysaccharide (LPS) associated with porins. The porins-mediated increase in interleukin transcripts did not require de novo protein synthesis, and it was because of the enhanced half-life of IL-1 and IL-6 mRNAs, rather an increased rate of gene transcription. These data suggest that porins may affect inflammatory and immunological responses by enhancing the expression of cytokine genes.

Published
1995

22. Microbiologia Medica tredicesima edizione

Author

Barbanti Brodano, G, Bistoni, F, Blasi, E, Carosi, G, Castelli, F, CECCHERINI-NELLI, Luca, Cevenini, R, Chezzi, C, Chiarini, A, Coluzzi, M, Conti, S, Furlini, G, Galdiero, F, Gallinella, G, Giammanco, A, Gibellini, D, Landini, Mp, La Placa Mlo, Mateelli, A, Musiani, M, Orefici, G, Polonelli, L, Portolani, M, Re, Mc, Ripalti, A, Romani, L, Sambri, V, Schito, Gc, Toniolo, A, Verani borgucci, A, and Zerbini, M.

Subjects
Microbiologia, Microbiologia Medica
Published
2002

29. Starfish saponins, part 49 : new cytotoxic steroidal glycosides from the starfish Fromia monilis

Author

Casapullo, A., Finamore, E., Minale, L., Zollo, F., Carré, J.B., Debitus, Cécile, Laurent, Dominique, Folgore, A., and Galdiero, F.

Subjects
SAPONINE, ACTIVITE BIOLOGIQUE, SUBSTANCE NATURELLE, ANALYSE SPECTRALE, CYTOTOXICITE, STEROIDE, INVERTEBRE AQUATIQUE, ETOILE DE MER, STRUCTURE CHIMIQUE
Abstract

Nine new cytotoxic steroidal glycosides 1-9 have been isolated from the starfish #Fromia monilis$ collected off New Caledonia. Structures of these compounds, which include four mono- (1-4), two di- (5,6), and three tri-glycosides (7-9), were elucidated through spectral interpretation. Monilosides G (7), H (8), and I (9) are the first tri-glycosides to be found amoung the group of glycosides of polyhydroxilated steroids from starfishes. (Résumé d'auteur)

Published
1993

49. Ethanol-induced suppression of resistance to experimental infection by Salmonella...

Author

Galdiero, F. and Nuzzo, I.

Subjects
*ALCOHOLISM, *LABORATORY mice, *IMMUNODEFICIENCY, *DISEASE risk factors
Abstract

Describes the results in a mouse model where ethanol (ETOH) was administered in a liquid diet. Aspects of the specific and non-specific immunologic responses; Increase in mortality with an increase in the number of circulating bacteria; Decrease in adherence and migrational capacity of polymorphonuclear leukocytes; Decrease in response of lymphocytes to polyclonal stimuli.

Published
1995
Full Text
View/download PDF

50. Interleukin-1 and interleukin-6 gene expression in human monocytes stimulated with <em>Salmonella typhimurium</em> porins.

Author

Galdiero, M., de L'Ero, G. Cipollaro, Donnarumma, G., Marcatili, A., and Galdiero, F.

Subjects
INTERLEUKINS, MONOCYTES, SALMONELLA typhimurium, CELL culture, GENE expression, IMMUNOREGULATION
Abstract

The aim of this study was to verify whether Salmonella typhimurium porins can affect the expression of interleukin-1 (IL-1) and interleukin-6 (IL-6) genes. Human monocytes were treated with porins, and total RNAs were analysed by Northern blotting to evaluate the expression of IL- 1α IL-1β and IL-6 in both treated and untreated cell cultures. Porins induced a significant increase in IL-1 and IL-6 transcripts. This increase was related to the dose of porins, and it peaked 5 hr after treatment. The same results were obtained when polymyxin B was added to the porin preparation to eliminate eventual traces of lipopolysaccharide (LPS) associated with porins. The porins-mediated increase in interleukin transcripts did not require de novo protein synthesis, and it was because of the enhanced half-life of IL-1 and IL-6 mRNAs, rather an increased rate of gene transcription. These data suggest that porins may affect inflammatory and immunological responses by enhancing the expression of cytokine genes. [ABSTRACT FROM AUTHOR]

Published
1995

Catalog

Books, media, physical & digital resources
See catalog results