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3. Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice

Author

Hunt, Andrew C, Case, James Brett, Park, Young-Jun, Cao, Longxing, Wu, Kejia, Walls, Alexandra C, Liu, Zhuoming, Bowen, John E, Yeh, Hsien-Wei, Saini, Shally, Helms, Louisa, Zhao, Yan Ting, Hsiang, Tien-Ying, Starr, Tyler N, Goreshnik, Inna, Kozodoy, Lisa, Carter, Lauren, Ravichandran, Rashmi, Green, Lydia B, Matochko, Wadim L, Thomson, Christy A, Vögeli, Bastian, Krüger, Antje, VanBlargan, Laura A, Chen, Rita E, Ying, Baoling, Bailey, Adam L, Kafai, Natasha M, Boyken, Scott E, Ljubetič, Ajasja, Edman, Natasha, Ueda, George, Chow, Cameron M, Johnson, Max, Addetia, Amin, Navarro, Mary Jane, Panpradist, Nuttada, Gale, Michael, Freedman, Benjamin S, Bloom, Jesse D, Ruohola-Baker, Hannele, Whelan, Sean PJ, Stewart, Lance, Diamond, Michael S, Veesler, David, Jewett, Michael C, and Baker, David

Subjects
Medical Biotechnology, Engineering, Biomedical and Clinical Sciences, Biomedical Engineering, Vaccine Related, Lung, Emerging Infectious Diseases, Biodefense, Pneumonia, Autoimmune Disease, Infectious Diseases, Pneumonia & Influenza, Prevention, Biotechnology, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Good Health and Well Being, Animals, Antibodies, Neutralizing, Antibodies, Viral, COVID-19, Cryoelectron Microscopy, Humans, Mice, SARS-CoV-2, Spike Glycoprotein, Coronavirus, Biological Sciences, Medical and Health Sciences, Medical biotechnology, Biomedical engineering
Abstract

New variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue to arise and prolong the coronavirus disease 2019 (COVID-19) pandemic. Here, we used a cell-free expression workflow to rapidly screen and optimize constructs containing multiple computationally designed miniprotein inhibitors of SARS-CoV-2. We found the broadest efficacy was achieved with a homotrimeric version of the 75-residue angiotensin-converting enzyme 2 (ACE2) mimic AHB2 (TRI2-2) designed to geometrically match the trimeric spike architecture. Consistent with the design model, in the cryo-electron microscopy structure TRI2-2 forms a tripod at the apex of the spike protein that engaged all three receptor binding domains simultaneously. TRI2-2 neutralized Omicron (B.1.1.529), Delta (B.1.617.2), and all other variants tested with greater potency than the monoclonal antibodies used clinically for the treatment of COVID-19. TRI2-2 also conferred prophylactic and therapeutic protection against SARS-CoV-2 challenge when administered intranasally in mice. Designed miniprotein receptor mimics geometrically arrayed to match pathogen receptor binding sites could be a widely applicable antiviral therapeutic strategy with advantages over antibodies in greater resistance to viral escape and antigenic drift, and advantages over native receptor traps in lower chances of autoimmune responses.

Published
2022

4. Extracorporeal Life Support Organization Registry International Report 2022: 100,000 Survivors

Author

Tonna, Joseph E., Boonstra, Philip S., MacLaren, Graeme, Paden, Matthew, Brodie, Daniel, Anders, Marc, Hoskote, Aparna, Ramanathan, Kollengode, Hyslop, Rob, Fanning, Jeffrey J., Rycus, Peter, Stead, Christine, Barrett, Nicholas A., Mueller, Thomas, Gómez, Rene D., Malhotra Kapoor, Poonam, Fraser, John F., Bartlett, Robert H., Alexander, Peta M.A., Barbaro, Ryan P., Abbasi, Adeel, Said Abdalmohsen, Ahmad, Abdelbary, Akram M., Abecasis, Francisco, Abel, Peter, Abu-Omar, Yasir, Adams, Douglas R, Manuel Africano, Juan, Aganga, Devon, Agati, Salvatore, Agerstrand, Cara, Aguillon, Mario V., Akers, Crystal S., Akhtarekhavari, Julia, Alazzam, Mohammad Izzat Salah, Albert, Martin, Alberti, Angela, Al-Fares, Abdulrahman A., Alfoudri, Huda, Allaert, Silvie, Allbert, Keesha N., Allen, Christopher T., Lescano Alva, Miguel Ángel, Alwardt, Cory M., Amigoni, Angela, Anandamurthy, Balaram, Anastasiadis, Kyriakos, Anders, Nicholas R., Anderson, Scott A., Anderson, Patricia L., Andrijević, Ana, Annoni, Alice, Anselmi, Michael, Anstey, James R., Antonini, Marta V., Antonitsis, Polychronis, Stein Araujo, Tays, Arcalas, Rhodney, Areinamo, Igor, Martin Arias, Anibal, Armijo-Garcia, Veronica, Aronsky, Vladimir, Arora, Lovkesh, Arora, Madhur, Leigh Aspenleiter, Marit, Atik, Fernando A., AugustGeorg Auzinger, Erin Colleen, Azzam, Ismail, Bacchetta, Matthew, Bak, Erica I., Balcells, Joan, Sánchez Ballesteros, Jesús, Banjac, Igor S., Barbaria, Jacqueline M., Barrigoto, Cleide L., Bass, Stephanie D., Batranović, Uroš, Bauer, Matthew H., Fernando Bautista, Diego, Beck, Robert M., Giraldo Bejarano, Estefania, Belohlavek, Jan, Bembea, Melania M., Benes, Jan, Benharash, Peyman, Benish, Lynne A., Bennett, Suzanne, Bento, Luís F.N., Bermudez, Christian A., Bertini, Pietro, Best, Derek, Bharat, Ankit, Bhutta, Omar J., Bizzell, Samantha J., Blakeman, Stephanie A., Blanco-Schweizer, Pablo, Blanton, Jessica K., Blood, Peggy S., Bohlmann, Allison S., Kyle Bohman, John, Bombino, Michela, Kathleen Bonadonna, Desiree, Bond, Ashley, Borgmann, Kristina M., Bourgoin, Pierre, Boville, Brian M., Boza, Raquel, Brady, Heather L., Brady, Alison, Braunlich, Jessica M., Bridges, Brian C., Brinkley, Karen K., Brookshire, Robert S., Brozzi Nicole Brueggemann, Nicolas A., Buckley, Dwight P., Jr., Buckley, Klayton, Budhani, Irfan B., Bukamal, Nazar, Burgos, Lucrecia M, Burša, Filip, Busby, Landon K., Buscher, Hergen, Butler, Menoly, Butt, Warwick W., Byrnes, Jonathan W., Calaritis, Christos, Caldwell, Lisa R., Calligaro, Gregory L., Campbell, Patrick T., Camporota, Luigi, Fernando Caneo, Luiz, Jovo Carapic, Vladimir, Carrasco-Carrasco, Cristina, Ivan Carrizo, Nestor, Carrow, Heidi, Carton, Edmund G., Casabella, Christian, Gomez Casal, Vanesa, Casey, Francis L., III, Castillo, Andres, Castleberry, Anthony W., Alexandros Cavayas, Yiorgos, Cerqua, Karey, Ming Chan, Kai Man ChanWai, Brian Chapman, Jason, Brahma Chari, Hari, Cheifetz, Omair ChaudharyIra M., Chen, Robin H.S, Chen, Weiting, Cheung, Eva W., Cheung, Anson, Chico, Juan I., Chiletti, Roberto, Jin Cho, Hwa, Cholette, Jill M., Christensen, Steffen, Chui, Betty S., Circelli, Alessandro, Clement, Katherine C., Cleuziou, Julie, Clouse, Brian, Cole, Gwendolen, Coles, Garrett M., Collins, Monika F., Collins, Monika F., Connelly, James, Conrad, Steven A., Cook, Marlene, Copeland, Hannah, Copus, Scott C., Cox, Charles S., Jr, Craig, Lynne K., Crain, Natasha, Cremonese, Ricardo V., Criswell, Emily A., Cross, Lisa M., Crowley, Moira A., Crowley, Jerome C., Cruz, Leonora, Cypel, Marcelo, Czarnik, Tomasz, Czuczwa, Miroslaw E., Sica da Rocha, Taís, Daddow, Samuel, Dali, Dante C., Dalton, Heidi J., Daly, Kathleen J.R., Damuth, Emily, Daniel, Dennis A., Daniel IV, John M., Daniel, Josiane M., Danis, Max D., Danko, Melissa E., Rodrigues Dantas, Joao Alberto, Daoust, Isabelle, Dauwe, Dieter F., Davidson, Mark, Davis, Joel C., Davis, Mitchell, D’Cunha, Jonathan, de Arruda Bravim, Bruno, de BoodeKim T. De La Cruz, Willem P., Gray DeAngelis, Kathryn, Debeuckelaere, Gerdy, Deitemyer, Matthew A., DellaVolpe, Jeffrey, Deneau, Jamie L., DeNino, Walter F., Denmark, Christopher G., Denney, Derek, DeValeria, Patrick A., Dewulf, Petra, Di Nardo, Matteo, DiBardino, Daniel J., DiMartino, Joseph, Dimopoulos, Stavros, Domico, Michele B., Dominy, Meaghan E., Donker, Dirk W., Dresbach, Till, Droogh, Joep M., Dunlap, Tiffany W., Dupon, Allsion, Durham, Lucian A., III, Durward, Andrew, Dvorak, Anna, Dyett, John F., Dziedzina, Carol L., Eaken, Carmen L., Eaton, Jonathan S., Eberle, Christopher J., Edwards, Linda, Efseviou, Christakis, Eigner, Juliann M., Ahmed Elhamrawi, Hazem, Elhazmi, Alyaa M., Elizondo, Tammy, Ellersick, Beverly L., Emling, Jonathan A., Ernst, Andreas, Pablo Escalante, Juan, Espinoza, Otoniel, Evey, Lee W., Fan, Eddy, Fang, Gary, Faulkner, Gail M., Fauman, Karen R, Ferguson, Niall, Ferreira, Benigno, Fiane, Arnt E., Andrade Fierro, Dario, Martha Filippi, María, Findeisen, Michael C., Finlay, Katie, Finlayson, Gordon, Fischer, Gwenyth A., Fischer, Courtney D., Fischer, William J., III, Fisher, Caleb M., Fitriasari, Reni, Fitzgerald, Jillian, Fix, Melissa K., Fleming, Sarah B., Flynn, Brigid C., Forst, Beth A., Fortuna, Philip P., Foti, Giuseppe, Fox, Matthew P., Franco, Thais O., David Freeland, C., Fried, Justin A., Friedman, Matthew L., Furlanetto, Beatriz, Fux, Thomas, Gaião, Sérgio, Gale, Michael J., Garcia, Joann Kathleen G., Garcia-Montilla, Romel, Gardner, Eric R., Garg, Meena, Garrison, Lawrence L., Gavrilovic, Srdjan M., Gawda, Ryszard, Geer, Laura W., Gelandt, Elton A., Gelvin, Michael G., Genovese, Bradley M., George, Jeffrey A., George, Timothy J, George, Sangley, Ghimire, Anup, Giani, Marco, Gill, Baljit S., Glikes, Erin, Golecki, Michael, Gongora, Enrique, Govener, Sara, Graf, Amanda, Grasselli, Giacomo, Gray, Brian W., Greenlee, Joseph A., III, Gregoric, Igor D., Gregory, Melinda, Grins, Edgars, Volker Groesdonk, Heinrich, Group, Kimberly F., Guarracino, Fabio, Joy Guidi-Solloway, Alexandra, Gunn, Tyler M., Guru, Pramod K, Haddle, John C., Haft, Jonathan W., Haisz, Emma, Hall, Julie L., Hall, Cameron, Hamaguchi, Jun, Hammond, Terese C., Han, Peggy K., Hardison, Daphne C., Harischandra, Dickwelle T., Hart, Shaun M., Harting, Matthew T., Hartley, Louise, Harvey, Chris J., Hasan, Zubair, Fawzy Hassan, Ibrahim, Hastings, Jennifer R., Hatcher, Renee’, Hatton, Kevin W., Haught, Christopher K., Awori Hayanga, Jeremiah, Peter Haydon, Timothy, Healy, Aaron H., Heard, Micheal L., Heather, Beth M., Hendrix, Rik H.J., Hennig, Felix, Hermens, Greet HermansJeannine A.J., Hernandez, Deborah A., Hernandez-Montfort, Jaime, Herrera, Guillermo, Hickman, Keri, Hittel, Ashley, Hobbs, Crystal, Hoffman, Jordan R.H., Hollinger, Laura E., Homishak, Michael, Horigoshi, Nelson K., Hoshino, Kota, Huang, Shu-Chien, Huenges, Katharina, Hussey, Alexander D., Hyslop, Robert W., Ihle, Rayan E., Ingemansson, Ola, Ivulich, Daniel, Jackson, Amanda L., Garcia Jacques, Rogelio, Jain, Harsh, Jakobs, Sharon M., Jan, Robert, Janowiak, Lisa M., Jara, Claire B., Jarden, Angela M., Jarzembowski, Jamie L., Jaudon, Andrew, Kishore Jayanthi, Venkata Krishna, Jennings, Joseph A., Jeong, Inseok, Meza Jiménez, Rafael, Jimenez-Rodriguez, Gian M., Joachim, Sabrina, Joelsons, Daniel, Johnson, Caroline A., Johnson, Andrea L., Jones, Jeffry H., Joseph, Mark, Joseph, Sunimol, Joshi, Raja, Joyce, Christopher J., Seung Jung, Jae, Carone Junior, José, Kallas, Harry J., KamerkarPilje Kang, Asavari, Kar, Biswajit, Karapanagiotidis, Georgios T., Kattan, Javier, Kaufman, David A., Kawauchi, Akira, Keene, Sarah D., Keller, Norma M., Keller, Roberta, Kelley, Emily W., Kelley, Kellie, Kelly-Geyer, Janet F., Kenderessy, Peter, Kenny, Laura E., Keshavjee, Shaf, Kessel, D., Kessler, Heather, Keuler, Suzanne, Khicha, Sanjay, Wan Kim, Do, Kim, Richard Y., Maxwell Kime, Aaron, Kincade, Robert C., Kipfmueller, Florian, Kirk, Douglas A., Klein, Liviu, Knapp, Randall S., Knapp, Randall S., Kneyber, Martin C.J., Knowles, Andrea L., Koch, Jillian M., Koepke, Stephanie, Kogelmann, Klaus M., Elzo Kraemer, Carlos, Krauklis, Amanda, Krumroy, Samantha L., Kumar, Madhan, Kumar, Arun, Kumpf, Matthias E, Kyle, Kimberly, Laffin, Anna, Kees Lagrand, Wim, Lahiji, Parshawn A., Keung Lai, Peter Chi, Ka Lai, Cally Ho, Danielle Laird, Amanda, Landsberg, Michelle LaMarreDavid M., Lanmueller, Pia, Oude Lansink-Hartgring, Annemieke, Beth Larson, Sharon, Laufenberg, De’Ann M., Lavana, Jayshree, Layne, Tracie L., John Lazar, Michael, Ledoux, Matthew R., Lee, Raymond C., Leek, Thomas M., Lequier, Laurance, Lesbekov, Timur, Leslie, Robert, Anne Leung, Kit Hung, Lillie, Jon, Phang Lim, Yeong, Lim, Sang-Hyun, Lin, Ling, Lindsey, Thomas, Ho Ling, Steven Kin, Lingle, Kaitlyn J., Lipes, Jed, Liu, Songqiao, Llevadias, Judit, Lomas, Erin A., Longenecker, Robert D., Lorusso, Roberto, Ann Low, Tracy, Steven Lubinsky, Anthony, Lucas, Matthias LubnowMark T., Lucchini, Alberto, Luze, Lisa E., Lynch, William R., Manoj, M.C., Maas, Jacinta J., MacNamara, Vanessa, Madden, Jesse L., Maimone, Justin, Malhotra, Rajiv, Malone, Matthew P., Mangukia, Chirantan, Manzur-Sandoval, Daniel, Maráczi, Veronika, Marinaro, Jonathan L., Marinucci, Christina R., Marshall, Tammy, Martin, Mark, Marwali, Eva M., Maslach-Hubbard, Anna, Matijašević, Jovan, Mattke, Adrian, Mattucci, Joseph, Maul, Timothy M., Maybauer, Marc O., Mayette, Michael, Mayville, Joni R., McAllister, Catherine, McBride, Martha W., Scott McCaul, David, McClelland, Samantha L.S., Gregory McCloskey, Colin, McGregor, Randy, McKamie, Wesley A., McKee, Andrew D., McMahon, Chelsea M., McMullin, Kaye, McNicol, Jane, McNulty, John P., McRae, Thomas, Meade, Maureen E., Meersseman, Philippe, Mekeirele, Michael, Ito Mendes, Elisa, Menon, Anuradha P., Meyer, Jason P., Meyers, Jourdan E., Meyns, Bart, Mignone, John L., Miller, Brittany D., Miller, Malcolm G.A., Miller, Deborah, Mintak, Renee, Minter, Sarah M., Reis Miranda, Dinis, Mirza, Farrukh, Mishkin, Joseph D., Modelewski, Paul, Mohan, Rajeev C., Hui Mok, Yee, Money, Dustin, Monteagudo, Julie, Moores, Russell R., Jr., Moran, Patrick, Morelock, Shawn, Moreno, Marsha R., Blanco Morillo, Juan, Morrison, Tracy, Morton, John M., Morton, Brenda, Moscatelli, Andrea, Mosier, Jarrod M., Muellenbach, Ralf M., Mueller, Andreas, Mueller, Dale, Musca, Steven C., Nagpal, Dave, Najaf, Tasnim, Narasimhan, Mangala, Nater, Melissa, Natividad, Zynthia, Nedeljkov, Djordje, Nelson, Bryan D., Newman, Sally F., Newton, Debra E., Neyman, Jonathan L., George Ng, Wing Yiu, Nicholson, Meghan C., Nicolaas, Christine, Nix, Charlie, Nkwantabisa, Raymond, Nolan, Shirley, Norese, Mariano, Norton, Bridget M., Norton, Bridget M., O’Brien, Serena G., O’Callaghan, Maura, Oishi, Peter, O’Leary, Tony D., Olia, Salim E., O’Meara, Carlisle, Oppel, Emily E., Arias Ortiz, Julian, Oza, Pranay L., Ozment, Caroline P., Pacific, Marjorie, Pálizas, Fernando, Palmer, David, Paoletti, Luca, Pardo, Diego H., Paredes, Pablo, Patel, Thomas PasgaardMrunal G., Patel, Sandeep M., Patel, Vijay S., Patel, Brijesh V., PatelDrisya Paul, Sameer, Pawale, Amit A., Pearson, Nicole M., Renee Pearson, Crystal, Peek, Giles J., Pellecchia, Crescens M., Pellegrino, Vincent, Peperstraete, Harlinde, Perkins, Rebecca L., Perkins, Brandon, Peterec, Steven, Peterman, Claire, Phillips, Cooper W., Piekutowski, Richard R., Pilan, María L., Luisa Pilan, Maria, Mark Pincus, Jason, Pino, Melissa, Plambeck, Robert W., Plisco, Michael S., Plumley, Donald A., Plunkett, Mark D., Poffo, Robinson, Poh, Pei-Fen, Polito, Angelo, Pollema, Travis L, Pozzi, Matteo, Pozzi, Matteo, Pranikoff, Thomas, Prekker, Matthew E., Prossen, Erik F., Puligandla, Pramod S., Puslecki, Mateusz, Raheel Qureshi, Muhammad, Emilia Rabanal, Lily, Abdulhamid Rabie, Ahmed, Rackley, Craig R., Radovancevic, Rajko, Raes, Matthias, Allen Raff, Lauren Desiree, Rahban, Youssef, Raimer, Patricia L., Rajbanshi, Bijoy G., Ramanan, Raj, Rambaud, Jerome, Ramírez-Arce, Jorge A., Simões Ramos, Ana Carolina, Rao, Suresh G., Rector, Raymond, Redfors, Bengt, Regmi, Ashim, Alejandro Rey, Jose, Miguel Ribeiro, Joao, Richards, Chelsea E, Joan Richardson, C., Riddle, Christy C., Riera, Jordi, Ripardo, Marina, Rivas, Fernando M., Roan, Ronald M., Robertson, Elizabeth, Robinson, Megan, Röder, Daniel, Rodrigus, Inez E.R., Paul Roeleveld, Peter, Romano, Jennifer C., Rona, Roberto, Ann Rosenberg, Carol, Rosenow, Felix, Rowe, Robert J., Rower, Katy E., Rudolph, Kristina L., Fernando Rueda, Luis, Ruf, Bettina, Russell, Hyde M., Russell, Nichole, Ryan, Kathleen, Saberi, Asif A., Said, Ahmed S., Sailor, Caitlin, Sakal, Angela, Lujan Salas, Gisela, Salazar, Leonardo, Saleem, Kashif, Samoukovic, Gordan, Sanchez, Pablo G., Marie Santiago, Lian, Sargin, Murat, Miguel Sassine, Assad, Satou, Nancy L., Saunders, Paul C., Schachinger, Scott, Schaible, Thomas, Schellongowski, Peter, Schlager, Gerald W., Schmid, Christof, Schmitt, Joachim, Schnell, LeeAndra, Schnur, Janos, Schroeder, Lukas, Schubach, Scott, Schuetz, Michael T., Schwartz, Gary S., Schwarz, Patricia, Scriven, Nicole M., Seabrook, Ruth B., Seefeldt, Cassandra, Seelhammer, Troy G., Segura-Matute, Susana, Sen, Ayan, Adrian Seoane, Leonardo, Shaffer, Jamie, Shafi, Bilal M., Shambley, Shannon, Shankar, Shyam, Shapland, Amanda, Sharng, Yih, Shavelle, David, Sheldrake, Jayne, Mohan Shetty, Rajesh, Shiber, Joseph R., Shimzu, Naoki, Lou Short, Billie, Sichting, Kay A., Sidehamer, Keith E., Siebenaler, Teka, Silvestry, Scott C., Sinclair, Jennifer T, Sinclair, Andrew, Singh, Aalok R., Singh, Gurmeet, Skinner, Sean C., Smart, Alexandra, Smith, Reanna M., Smith, Adam, Smith, Karen, Sommer-Candelario, Sherri, Song, Seunghwan, Sorensen, Gro, Sousa, Eduardo, Sower, Christopher T., Spadea, Nicholas V, Spangle, April, Speicher, David G., Spieth, Peter M., Srivastava, Ankur, Srivastava, Neeraj, Stahl, Mark, Stallkamp, Eric D., Jr, Stanley, Vanessa J., Starr, Joanne P., Staudinger, Thomas, Stevens, Berkeley E., Stevens, Kimberly, Stocker, Christian, Strickland, Richard, Suarez, Erik E., Kumar Subramanian, Rakesh, Sudakevych, Serhii, Summerall, Charlene, Sundararajan, Santosh, Susupaus, Attapoom, Suzuki, Hiroyuki, Sweberg, Todd, Sydzyik, Troy, Anh Ta, Tuan, Tagliari, Luciana, Tanaka, Hiroyuki, Tanski, Christopher T., Tasset, Mark, Taylor, Donna M., Teman, Nicholas R., Ramesh Thangaraj, Paul, Thiagarajan, Ravi R., Thiruchelvam, Timothy, Thomas, James A., Thomas, Owain D., Thompson, Shaun L., Thomson, David A., Thukaram, Roopa, Todd, Mark L., Toeg, Hadi, Torres, Silvio F., Trautner, Simon, Trombino, Terry, Tuazon, Divina M., Tuel, Julie, Tukacs, Monika, Turner, April N., Tyree, Melissa M., Uchiyama, Prashant Vaijyanath, Makoto, van den Brule, Judith M.D., van Dyck, Marlice A., van Gijlswijk, Mascha, Van Meurs, Krisa P., VanDyck, Tyler J., Vardi, Amir, Vega, Alejandra, Ventetuolo, Corey E., Vera, Magdalena, Vercaemst, Leen, Vets, Philippe, Viamonte, Heather, Vidlund, Mårten, Vitali, Sally H., Vlaa, Alexander P.J., Vuylsteke, Alain, Loon Wan, Kah, Watkins, Reuben, Watson, Pia, Weast, Travis A., Weaver, Karen E., Welkovics, Norbert, Wellner, Heidi L., Wells, Jason C., Welter, Karen, Westpheling, Amber G., Whalen, Lesta D.S., Whebell, Stephen, Wiersema, Ubbo, Wiisanen, Matthew E., Eugene Wilcox, Bradley, Wille, Keith, Jan Will, Ellyne, Wilson, Brock J., Win, April M., Winearls, James R., Wise, Linda J., Witter, Tobias, Ruby Wong, Hoi Mei, Worku, Berhane, Wright, Tina M, Wu, James K., Yalon, Larissa A., Yantosh, Garrett, Yaranov, Dmitry M., Yee, Pat, Yi, Cassia, Yost, Christian C., Young, John, Younger, Katrina, Zaborowski, Steven, Zachmann, Brenda, Zainab, Asma, Zanai, Rosanna, Zhao, Ju, Zhou, Chengbin, and Zinger, Marcia

Published
2024
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5. Short and Wide Network Paths

Author

Marla, Lavanya, Varshney, Lav R., Shah, Devavrat, Prakash, Nirmal A., and Gale, Michael E.

Subjects
Computer Science - Neural and Evolutionary Computing, Electrical Engineering and Systems Science - Systems and Control, Physics - Physics and Society
Abstract

Network flow is a powerful mathematical framework to systematically explore the relationship between structure and function in biological, social, and technological networks. We introduce a new pipelining model of flow through networks where commodities must be transported over single paths rather than split over several paths and recombined. We show this notion of pipelined network flow is optimized using network paths that are both short and wide, and develop efficient algorithms to compute such paths for given pairs of nodes and for all-pairs. Short and wide paths are characterized for many real-world networks. To further demonstrate the utility of this network characterization, we develop novel information-theoretic lower bounds on computation speed in nervous systems due to limitations from anatomical connectivity and physical noise. For the nematode Caenorhabditis elegans, we find these bounds are predictive of biological timescales of behavior. Further, we find the particular C. elegans connectome is globally less efficient for information flow than random networks, but the hub-and-spoke architecture of functional subcircuits is optimal under constraint on number of synapses. This suggests functional subcircuits are a primary organizational principle of this small invertebrate nervous system.

Published
2019

7. Proteome-Wide Zika Virus CD4 T Cell Epitope and HLA Restriction Determination

Author

Campbell, Victoria L, Nguyen, LeAnn, Snoey, Elise, McClurkan, Christopher L, Laing, Kerry J, Dong, Lichun, Sette, Alessandro, Lindestam Arlehamn, Cecilia S, Altmann, Danny M, Boyton, Rosemary J, Roby, Justin A, Gale, Michael, Stone, Mars, Busch, Michael P, Norris, Phillip J, and Koelle, David M

Subjects
Vaccine Related, Infectious Diseases, Biodefense, Emerging Infectious Diseases, Vector-Borne Diseases, Immunization, Biotechnology, Prevention, Clinical Research, 2.1 Biological and endogenous factors, Aetiology, Infection, Good Health and Well Being, Adult, Aged, Animals, CD4-Positive T-Lymphocytes, Chlorocebus aethiops, Cross Reactions, Epitopes, T-Lymphocyte, Female, Humans, Male, Middle Aged, Proteome, Vero Cells, Young Adult, Zika Virus, Zika Virus Infection
Abstract

Zika virus (ZIKV) is a mosquito-borne pathogen that caused an epidemic in 2015-2016. ZIKV-specific T cell responses are functional in animal infection models, and helper CD4 T cells promote avid Abs in the vaccine context. The small volumes of blood available from field research limit the determination of T cell epitopes for complex microbes such as ZIKV. The goal of this project was efficient determination of human ZIKV CD4 T cell epitopes at the whole proteome scale, including validation of reactivity to whole pathogen, using small blood samples from convalescent time points when T cell response magnitude may have waned. Polyclonal enrichment of candidate ZIKV-specific CD4 T cells used cell-associated virus, documenting that T cells in downstream peptide analyses also recognize whole virus after Ag processing. Sequential query of bulk ZIKV-reactive CD4 T cells with pooled/single ZIKV peptides and molecularly defined APC allowed precision epitope and HLA restriction assignments across the ZIKV proteome and enabled discovery of numerous novel ZIKV CD4 T cell epitopes. The research workflow is useful for the study of emerging infectious diseases with a very limited human blood sample availability.

Published
2020

8. RNA-binding protein isoforms ZAP-S and ZAP-L have distinct antiviral and immune resolution functions

Author

Schwerk, Johannes, Soveg, Frank W, Ryan, Andrew P, Thomas, Kerri R, Hatfield, Lauren D, Ozarkar, Snehal, Forero, Adriana, Kell, Alison M, Roby, Justin A, So, Lomon, Hyde, Jennifer L, Gale, Michael, Daugherty, Matthew D, and Savan, Ram

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Biological Sciences, Prevention, Infectious Diseases, Emerging Infectious Diseases, Vaccine Related, Genetics, Biodefense, Underpinning research, 1.1 Normal biological development and functioning, Inflammatory and immune system, Infection, Alphavirus Infections, Feedback, Physiological, HEK293 Cells, Hep G2 Cells, Homeostasis, Humans, Immunity, Innate, Interferon Regulatory Factor-3, Interferons, Protein Binding, Protein Isoforms, RNA, RNA, Small Interfering, RNA-Binding Proteins, Repressor Proteins, Sindbis Virus, Virus Replication, Immunology, Biochemistry and cell biology
Abstract

The initial response to viral infection is anticipatory, with host antiviral restriction factors and pathogen sensors constantly surveying the cell to rapidly mount an antiviral response through the synthesis and downstream activity of interferons. After pathogen clearance, the host's ability to resolve this antiviral response and return to homeostasis is critical. Here, we found that isoforms of the RNA-binding protein ZAP functioned as both a direct antiviral restriction factor and an interferon-resolution factor. The short isoform of ZAP bound to and mediated the degradation of several host interferon messenger RNAs, and thus acted as a negative feedback regulator of the interferon response. In contrast, the long isoform of ZAP had antiviral functions and did not regulate interferon. The two isoforms contained identical RNA-targeting domains, but differences in their intracellular localization modulated specificity for host versus viral RNA, which resulted in disparate effects on viral replication during the innate immune response.

Published
2019

10. Duration of viral infectiousness and correlation with symptoms and diagnostic testing in non-hospitalized adults during acute SARS-CoV-2 infection: A longitudinal cohort study

Author

Drain, Paul K., Dalmat, Ronit R., Hao, Linhui, Bemer, Meagan J., Budiawan, Elvira, Morton, Jennifer F., Ireton, Renee C., Hsiang, Tien-Ying, Marfatia, Zarna, Prabhu, Roshni, Woosley, Claire, Gichamo, Adanech, Rechkina, Elena, Hamilton, Daphne, Montaño, Michalina, Cantera, Jason L., Ball, Alexey S., Golez, Inah, Smith, Elise, Greninger, Alexander L., McElrath, M.Juliana, Thompson, Matthew, Grant, Benjamin D., Meisner, Allison, Gottlieb, Geoffrey S., and Gale, Michael, Jr.

Published
2023
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13. Increased mucosal neutrophil survival is associated with altered microbiota in HIV infection.

Author

Hensley-McBain, Tiffany, Wu, Michael C, Manuzak, Jennifer A, Cheu, Ryan K, Gustin, Andrew, Driscoll, Connor B, Zevin, Alexander S, Miller, Charlene J, Coronado, Ernesto, Smith, Elise, Chang, Jean, Gale, Michael, Somsouk, Ma, Burgener, Adam D, Hunt, Peter W, Hope, Thomas J, Collier, Ann C, and Klatt, Nichole R

Subjects
Colon, Rectum, Neutrophils, Humans, HIV-1, HIV Infections, Inflammation, Middle Aged, Female, Male, Gastrointestinal Microbiome, Microbiology, Immunology, Medical Microbiology, Virology
Abstract

Gastrointestinal (GI) mucosal dysfunction predicts and likely contributes to non-infectious comorbidities and mortality in HIV infection and persists despite antiretroviral therapy. However, the mechanisms underlying this dysfunction remain incompletely understood. Neutrophils are important for containment of pathogens but can also contribute to tissue damage due to their release of reactive oxygen species and other potentially harmful effector molecules. Here we used a flow cytometry approach to investigate increased neutrophil lifespan as a mechanism for GI neutrophil accumulation in chronic, treated HIV infection and a potential role for gastrointestinal dysbiosis. We report that increased neutrophil survival contributes to neutrophil accumulation in colorectal biopsy tissue, thus implicating neutrophil lifespan as a new therapeutic target for mucosal inflammation in HIV infection. Additionally, we characterized the intestinal microbiome of colorectal biopsies using 16S rRNA sequencing. We found that a reduced Lactobacillus: Prevotella ratio associated with neutrophil survival, suggesting that intestinal bacteria may contribute to GI neutrophil accumulation in treated HIV infection. Finally, we provide evidence that Lactobacillus species uniquely decrease neutrophil survival and neutrophil frequency in vitro, which could have important therapeutic implications for reducing neutrophil-driven inflammation in HIV and other chronic inflammatory conditions.

Published
2019

14. Replicating RNA platform enables rapid response to the SARS-CoV-2 Omicron variant and elicits enhanced protection in naïve hamsters compared to ancestral vaccine

Author

Hawman, David W., Meade-White, Kimberly, Clancy, Chad, Archer, Jacob, Hinkley, Troy, Leventhal, Shanna S., Rao, Deepashri, Stamper, Allie, Lewis, Matthew, Rosenke, Rebecca, Krieger, Kyle, Randall, Samantha, Khandhar, Amit P., Hao, Linhue, Hsiang, Tien-Ying, Greninger, Alexander L., Gale, Michael, Jr, Berglund, Peter, Fuller, Deborah Heydenburg, Rosenke, Kyle, Feldmann, Heinz, and Erasmus, Jesse H.

Published
2022
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17. Performance of anterior nares and tongue swabs for nucleic acid, Nucleocapsid, and Spike antigen testing for detecting SARS-CoV-2 against nasopharyngeal PCR and viral culture

Author

Montaño, Michalina A., Bemer, Meagan J., Heller, Kate B., Meisner, Allison, Marfatia, Zarna, Rechkina, Elena A., Padgett, Leah R., Ahls, Charlotte L., Rains, Douglas, Hao, Linhui, Hsiang, Tien-Ying, Cangelosi, Gerard A., Greninger, Alexander L., Cantera, Jason L., Golden, Allison, Peck, Roger B., Boyle, David S., Gale, Michael, Jr, and Drain, Paul K.

Published
2022
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18. Sociocultural Factors and Referral Outcome: An Exploratory Investigation

Author

Gale, Michael, Franco, Marisa, Reese, Erin, Hutman, Heidi, and Wang, Yu-Wei

Abstract

One response to increased service needs at university counseling centers has been community provider referrals. However, certain demographic groups may be more successful in these referrals than others. We hypothesized that students who identify as White, female, sexual minority, and older, would be more likely to be successfully referred. Self-reported demographic information was collected from clients at a Mid-Atlantic counseling center. A logistic regression analysis was conducted to test differences in referral status. Age alone emerged as significant, with older students being more likely than younger students to have a successful referral outcome. Implications of these findings are discussed.

Published
2020
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20. Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates.

Author

Dudley, Dawn M, Van Rompay, Koen K, Coffey, Lark L, Ardeshir, Amir, Keesler, Rebekah I, Bliss-Moreau, Eliza, Grigsby, Peta L, Steinbach, Rosemary J, Hirsch, Alec J, MacAllister, Rhonda P, Pecoraro, Heidi L, Colgin, Lois M, Hodge, Travis, Streblow, Daniel N, Tardif, Suzette, Patterson, Jean L, Tamhankar, Manasi, Seferovic, Maxim, Aagaard, Kjersti M, Martín, Claudia Sánchez-San, Chiu, Charles Y, Panganiban, Antonito T, Veazey, Ronald S, Wang, Xiaolei, Maness, Nicholas J, Gilbert, Margaret H, Bohm, Rudolf P, Adams Waldorf, Kristina M, Gale, Michael, Rajagopal, Lakshmi, Hotchkiss, Charlotte E, Mohr, Emma L, Capuano, Saverio V, Simmons, Heather A, Mejia, Andres, Friedrich, Thomas C, Golos, Thaddeus G, and O'Connor, David H

Subjects
Animals, Primates, Abortion, Spontaneous, Pregnancy, Female, Male, Stillbirth, Kaplan-Meier Estimate, Zika Virus, Zika Virus Infection, Abortion, Spontaneous, Immunology, Medical and Health Sciences
Abstract

Zika virus (ZIKV) infection is associated with congenital defects and pregnancy loss. Here, we found that 26% of nonhuman primates infected with Asian/American ZIKV in early gestation experienced fetal demise later in pregnancy despite showing few clinical signs of infection. Pregnancy loss due to asymptomatic ZIKV infection may therefore be a common but under-recognized adverse outcome related to maternal ZIKV infection.

Published
2018

21. Congenital Zika virus infection as a silent pathology with loss of neurogenic output in the fetal brain

Author

Adams Waldorf, Kristina M, Nelson, Branden R, Stencel-Baerenwald, Jennifer E, Studholme, Colin, Kapur, Raj P, Armistead, Blair, Walker, Christie L, Merillat, Sean, Vornhagen, Jay, Tisoncik-Go, Jennifer, Baldessari, Audrey, Coleman, Michelle, Dighe, Manjiri K, Shaw, Dennis WW, Roby, Justin A, Santana-Ufret, Veronica, Boldenow, Erica, Li, Junwei, Gao, Xiaohu, Davis, Michael A, Swanstrom, Jesica A, Jensen, Kara, Widman, Douglas G, Baric, Ralph S, Medwid, Joseph T, Hanley, Kathryn A, Ogle, Jason, Gough, G Michael, Lee, Wonsok, English, Chris, Durning, W McIntyre, Thiel, Jeff, Gatenby, Chris, Dewey, Elyse C, Fairgrieve, Marian R, Hodge, Rebecca D, Grant, Richard F, Kuller, LaRene, Dobyns, William B, Hevner, Robert F, Gale, Michael, and Rajagopal, Lakshmi

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Infection, Neurological, Good Health and Well Being, Animals, Disease Models, Animal, Female, Fetus, Humans, Macaca nemestrina, Microcephaly, Neurogenesis, Pregnancy, Pregnancy Complications, Infectious, Zika Virus, Zika Virus Infection, Medical and Health Sciences, Immunology, Biomedical and clinical sciences, Health sciences
Abstract

Zika virus (ZIKV) is a flavivirus with teratogenic effects on fetal brain, but the spectrum of ZIKV-induced brain injury is unknown, particularly when ultrasound imaging is normal. In a pregnant pigtail macaque (Macaca nemestrina) model of ZIKV infection, we demonstrate that ZIKV-induced injury to fetal brain is substantial, even in the absence of microcephaly, and may be challenging to detect in a clinical setting. A common and subtle injury pattern was identified, including (i) periventricular T2-hyperintense foci and loss of fetal noncortical brain volume, (ii) injury to the ependymal epithelium with underlying gliosis and (iii) loss of late fetal neuronal progenitor cells in the subventricular zone (temporal cortex) and subgranular zone (dentate gyrus, hippocampus) with dysmorphic granule neuron patterning. Attenuation of fetal neurogenic output demonstrates potentially considerable teratogenic effects of congenital ZIKV infection even without microcephaly. Our findings suggest that all children exposed to ZIKV in utero should receive long-term monitoring for neurocognitive deficits, regardless of head size at birth.

Published
2018

22. CD4-mediated immunity shapes neutrophil-driven tuberculous pathology

Author

Gern, Benjamin H, primary, Klas, Josepha M, additional, Foster, Kimberly A, additional, Cohen, Sara B, additional, Plumlee, Courtney R, additional, Duffy, Fergal J, additional, Neal, Maxwell L, additional, Halima, Mehnaz, additional, Gustin, Andrew T, additional, Diercks, Alan H, additional, Aderem, Alan, additional, Gale, Michael, additional, Aitchison, John D, additional, Gerner, Michael Y, additional, and Urdahl, Kevin B, additional

Published
2024
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26. Angiopoietin-Like4 Is a Novel Marker of COVID-19 Severity

Author

Bhatraju, Pavan K., Morrell, Eric D., Stanaway, Ian B., Sathe, Neha A., Srivastava, Avantika, Postelnicu, Radu, Green, Richard, Andrews, Adair, Gonzalez, Martin, Kratochvil, Christopher J., Kumar, Vishakha K., Hsiang, Tien-Ying, Gale, Michael, Jr, Anesi, George L., Wyles, David, Broadhurst, M. Jana, Brett-Major, David, Mukherjee, Vikramjit, Sevransky, Jonathan E., Landsittel, Douglas, Hung, Chi, Altemeier, William A., Gharib, Sina A., Uyeki, Timothy M., Cobb, J. Perren, Liebler, Janice M., Crosslin, David R., Jarvik, Gail P., Segal, Leopoldo N., Evans, Laura, Mikacenic, Carmen, and Wurfel, Mark M.

Published
2023
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28. The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity

Author

Gorman, Jacquelyn A, Hundhausen, Christian, Errett, John S, Stone, Amy E, Allenspach, Eric J, Ge, Yan, Arkatkar, Tanvi, Clough, Courtnee, Dai, Xuezhi, Khim, Socheath, Pestal, Kathleen, Liggitt, Denny, Cerosaletti, Karen, Stetson, Daniel B, James, Richard G, Oukka, Mohamed, Concannon, Patrick, Gale, Michael, Buckner, Jane H, and Rawlings, David J

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Immunology, Prevention, Vaccine Related, Emerging Infectious Diseases, Autoimmune Disease, Biodefense, Inflammatory and immune system, Adolescent, Adult, Animals, Autoimmune Diseases, Autoimmunity, Blotting, Southern, Cardiovirus Infections, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 1, Encephalomyocarditis virus, Female, Genetic Predisposition to Disease, HEK293 Cells, Humans, Immunoblotting, Interferon Type I, Interferon-Induced Helicase, IFIH1, Male, Mice, Middle Aged, Polymorphism, Single Nucleotide, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, Virus Diseases, Young Adult, Biochemistry and cell biology
Abstract

The single-nucleotide polymorphism rs1990760 in the gene encoding the cytosolic viral sensor IFIH1 results in an amino-acid change (A946T; IFIH1T946) that is associated with multiple autoimmune diseases. The effect of this polymorphism on both viral sensing and autoimmune pathogenesis remains poorly understood. Here we found that human peripheral blood mononuclear cells (PBMCs) and cell lines expressing the risk variant IFIH1T946 exhibited heightened basal and ligand-triggered production of type I interferons. Consistent with those findings, mice with a knock-in mutation encoding IFIH1T946 displayed enhanced basal expression of type I interferons, survived a lethal viral challenge and exhibited increased penetrance in autoimmune models, including a combinatorial effect with other risk variants. Furthermore, IFIH1T946 mice manifested an embryonic survival defect consistent with enhanced responsiveness to RNA self ligands. Together our data support a model wherein the production of type I interferons driven by an autoimmune risk variant and triggered by ligand functions to protect against viral challenge, which probably accounts for its selection within human populations but provides this advantage at the cost of modestly promoting the risk of autoimmunity.

Published
2017

32. Antibiotic-induced microbiome perturbations are associated with significant alterations to colonic mucosal immunity in rhesus macaques

Author

Manuzak, Jennifer A., Zevin, Alexander S., Cheu, Ryan, Richardson, Brian, Modesitt, Jacob, Hensley-McBain, Tiffany, Miller, Charlene, Gustin, Andrew T., Coronado, Ernesto, Gott, Toni, Fang, Mike, Cartwright, Michael, Wangari, Solomon, Agricola, Brian, May, Drew, Smith, Elise, Hampel, Hans Benjamin, Gale, Michael, Cameron, Cheryl M., Cameron, Mark J., Smedley, Jeremy, and Klatt, Nichole R.

Published
2020
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34. Learning the lute in early modern England, c.1550 - c.1640

Author

Gale, Michael, Brooks, Laura, Kenny, Elizabeth, and King, Ros

Subjects
787.8, DA Great Britain, MT Musical instruction and study
Abstract

This study explores the popularity of lute instruction in late sixteenth- and early seventeenth-century England and the ways in which this accomplishment was used in constructions of social status. The opening chapter outlines the functions of the lute in early modern English culture and surveys previous research on the instrument and its repertory. Chapter 2 provides an overview of the hierarchical structure of Elizabethan society, highlighting shifting conceptions of “gentle” status during the sixteenth century. The complex position of music within early modern discourses on elite identity is discussed, alongside the potential of lute-playing skills to contribute towards social advancement. Four case studies follow, each exploring the uses of lute-playing amongst practitioners located on the hazily defined boundaries between “gentle” and lower-class status. Chapter 3 uses the autobiography of Thomas Whythorne as a focal point in order to examine the ambiguous role of musicians in household service. By teaching coveted “courtly” skills to their social superiors, these music tutors were in an advantageous position to secure further rewards and enhance their status. Chapter 4 reassesses the Mynshall lutebook, highlighting the roles of music-making and literary production amongst a circle of mercantile-class men in provincial England. It reveals how lute-playing and poetic exchange facilitated social interaction and consolidated kinship bonds within this group as they sought to forge a collective identity grounded in the cultural practices of more elite circles. The role of recreational music-making amongst university men is examined in Chapter 5 through a reappraisal of the Dallis lutebook, showing how playing and collecting lute music could form a strand in the fashioning of a distinctively learned “scholarly” identity. My final case study assesses the printed tutor books marketed from the 1560s onwards, paying close attention to the material forms of extant copies (as evidence of their usage) and their paratextual materials. A close reading of Thomas Robinson’s Schoole of Musicke (1603) reveals how this publication was designed to appeal simultaneously to two very different markets: aspirant middle-class autodidacts, and wealthier “gentleman” readers who could provide further patronage and career advancement to the author.

Published
2014

35. Disruption of myelin structure and oligodendrocyte maturation in a pigtail macaque model of congenital Zika infection

Author

Tisoncik-Go, Jennifer, primary, Stokes, Caleb, additional, Whitmore, Leanne, additional, Newhouse, Daniel J, additional, Voss, Kathleen, additional, Gustin, Andrew, additional, Song, Cheng-Jung, additional, Smith, Elise, additional, Stencel-Baerenwald, Jennifer, additional, Parker, Edward D, additional, Snyder, Jessica M, additional, Shaw, Dennis, additional, Rajagopal, Lakshmi, additional, Kapur, Raj P, additional, Waldorf, Kristina Adams, additional, and Gale, Michael, additional

Published
2023
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36. Cellular RNA interacts with MAVS to promote antiviral signaling

Author

Gokhale, Nandan S, primary, Somfleth, Kim, additional, Thompson, Matthew G, additional, Sam, Russell K, additional, Marciniak, Daphnée M, additional, Chu, Lan H, additional, Park, Moonhee, additional, Dvorkin, Steve, additional, Oberst, Andrew, additional, Horner, Stacy M, additional, Ong, Shao-En, additional, Gale, Michael, additional, and Savan, Ram, additional

Published
2023
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41. Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 That Exhibits Antiviral Efficacy in SARS-CoV-2-Infected African Green Monkeys

Author

Mackman, Richard L., primary, Kalla, Rao V., additional, Babusis, Darius, additional, Pitts, Jared, additional, Barrett, Kimberly T., additional, Chun, Kwon, additional, Du Pont, Venice, additional, Rodriguez, Lauren, additional, Moshiri, Jasmine, additional, Xu, Yili, additional, Lee, Michael, additional, Lee, Gary, additional, Bleier, Blake, additional, Nguyen, Anh-Quan, additional, O’Keefe, B. Michael, additional, Ambrosi, Andrea, additional, Cook, Meredith, additional, Yu, Joy, additional, Dempah, Kassibla Elodie, additional, Bunyan, Elaine, additional, Riola, Nicholas C., additional, Lu, Xianghan, additional, Liu, Renmeng, additional, Davie, Ashley, additional, Hsiang, Tien-Ying, additional, Dearing, Justin, additional, Vermillion, Meghan, additional, Gale, Michael, additional, Niedziela-Majka, Anita, additional, Feng, Joy Y., additional, Hedskog, Charlotte, additional, Bilello, John P., additional, Subramanian, Raju, additional, and Cihlar, Tomas, additional

Published
2023
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46. Increased interregional virus exchange and nucleotide diversity outline the expansion of chikungunya virus in Brazil

Author

Xavier, Joilson, primary, Alcantara, Luiz Carlos Junior, additional, Fonseca, Vagner, additional, Lima, Mauricio, additional, Castro, Emerson, additional, Fritsch, Hegger, additional, Oliveira, Carla, additional, Guimarães, Natalia, additional, Adelino, Talita, additional, Evaristo, Mariane, additional, Rodrigues, Evandra S., additional, Santos, Elaine Vieira, additional, de La-Roque, Debora, additional, de Moraes, Laise, additional, Tosta, Stephane, additional, Neto, Adelino, additional, Rosewell, Alexander, additional, Mendonça, Ana Flavia, additional, Leite, Anderson, additional, Vasconcelos, Andreza, additional, Silva de Mello, Arabela L., additional, Vasconcelos, Bergson, additional, Montalbano, Camila A., additional, Zanluca, Camila, additional, Freitas, Carla, additional, de Albuquerque, Carlos F. C., additional, Duarte dos Santos, Claudia Nunes, additional, Santos, Cleiton S., additional, dos Santos, Cliomar Alves, additional, Gonçalves, Crhistinne C. Maymone, additional, Teixeira, Dalane, additional, Neto, Daniel F. L., additional, Cabral, Diego, additional, de Oliveira, Elaine C., additional, Noia Maciel, Ethel L., additional, Pereira, Felicidade Mota, additional, Iani, Felipe, additional, de Carvalho, Fernanda P., additional, Andrade, Gabriela, additional, Bezerra, Gabriela, additional, de Castro Lichs, Gislene G., additional, Pereira, Glauco Carvalho, additional, Barroso, Haline, additional, Franz, Helena Cristina Ferreira, additional, Ferreira, Hivylla, additional, Gomes, Iago, additional, Riediger, Irina N., additional, Rodrigues, Isabela, additional, de Siqueira, Isadora C., additional, Silva, Jacilane, additional, Rico, Jairo Mendez, additional, Lima, Jaqueline, additional, Abrantes, Jayra, additional, do Nascimento, Jean Phellipe M., additional, Wasserheit, Judith N., additional, Pastor, Julia, additional, de Magalhães, Jurandy J. F., additional, Luz, Kleber Giovanni, additional, Lima Neto, Lidio G., additional, Frutuoso, Livia C. V., additional, da Silva, Luana Barbosa, additional, Sena, Ludmila, additional, de Sousa, Luis Arthur F., additional, Pereira, Luiz Augusto, additional, Demarchi, Luiz, additional, Câmara, Magaly C. B., additional, Astete, Marcela G., additional, Almiron, Maria, additional, Lima, Maricelia, additional, Umaki Zardin, Marina C. S., additional, Presibella, Mayra M., additional, Falcão, Melissa B., additional, Gale, Michael, additional, Freire, Naishe, additional, Marques, Nelson, additional, de Moura, Noely F. O., additional, Almeida Da Silva, Pedro E., additional, Rabinowitz, Peter, additional, da Cunha, Rivaldo V., additional, Trinta, Karen S., additional, do Carmo Said, Rodrigo F., additional, Kato, Rodrigo, additional, Stabeli, Rodrigo, additional, de Jesus, Ronaldo, additional, Hans Santos, Roselene, additional, Kashima, Simone, additional, Slavov, Svetoslav N., additional, Andrade, Tamires, additional, Rocha, Themis, additional, Carneiro, Thiago, additional, Nardy, Vanessa, additional, da Silva, Vinicius, additional, Carvalho, Walterlene G., additional, Van Voorhis, Wesley C., additional, Araujo, Wildo N., additional, de Filippis, Ana M. B., additional, and Giovanetti, Marta, additional

Published
2023
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47. Viral Resistance Analyses From the Remdesivir Phase 3 Adaptive COVID-19 Treatment Trial-1 (ACTT-1)

Author

Hedskog, Charlotte, primary, Rodriguez, Lauren, additional, Roychoudhury, Pavitra, additional, Huang, Meei-Li, additional, Jerome, Keith R, additional, Hao, Linhui, additional, Ireton, Renee C, additional, Li, Jiani, additional, Perry, Jason K, additional, Han, Dong, additional, Camus, Gregory, additional, Greninger, Alexander L, additional, Gale, Michael, additional, and Porter, Danielle P, additional

Published
2023
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48. Rapid Antigen and Antibody Microfluidic Immunofluorescence Assays Compared to Culture, PCR, and Laboratory Reference Tests: Performance in a Longitudinal Cohort

Author

Dalmat, Ronit R, primary, Hao, Linhui, additional, Prabhu, Roshni, additional, Rechkina, Elena, additional, Hamilton, Daphne, additional, Ikuma, Matthew H, additional, Bauer, Marie, additional, Gale, Michael, additional, Cantera, Jason L, additional, Ball, Alexey S, additional, Grant, Benjamin D, additional, and Drain, Paul K, additional

Published
2023
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