Author: "Galgani, Simonetta" - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"Galgani, Simonetta"' showing total 175 results

Start Over Author "Galgani, Simonetta"

175 results on '"Galgani, Simonetta"'

1. Long-term effectiveness of natalizumab in secondary progressive multiple sclerosis: A propensity-matched study

Author: Avolio, Carlo, Balgera, Roberto, Banfi, Paola, Bellantonio, Paolo, Bramanti, Placido, Capone, Lorenzo, Cavalletti, Guido, Chiveri, Luca, Clerici, Raffaella, Clerico, Marinella, Corea, Francesco, Dattola, Vincenzo, De Robertis, Francesca, Di Battista, Giancarlo, Galgani, Simonetta, Gatto, Maurizia, Grasso, Maria Grazia, Inglese, Matilde, Lo Russo, Lorenzo, Logullo, Francesco Ottavio, Mantegazza, Renato, Protti, Alessandra, Rezzonico, Monica, Rottoli, Mariarosa, Salvetti, Marco, Scarpini, Elio, Sinisi, Leonardo, Sparaco, Maddalena, Spitaleri, Daniele, Tassinari, Tiziana, Tonietti, Simone, Valentino, Paola, Valzania, Franco, Venturi, Simonetta, Chisari, Clara G., Aguglia, Umberto, Amato, Maria Pia, Bergamaschi, Roberto, Bertolotto, Antonio, Bonavita, Simona, Morra, Vincenzo Brescia, Cavalla, Paola, Cocco, Eleonora, Conte, Antonella, Cottone, Salvatore, De Luca, Giovanna, Di Sapio, Alessia, Filippi, Massimo, Gallo, Antonio, Gasperini, Claudio, Granella, Franco, Lus, Giacomo, Maimone, Davide, Maniscalco, Giorgia Teresa, Marfia, Girolama, Moiola, Lucia, Paolicelli, Damiano, Pesci, Ilaria, Ragonese, Paolo, Rovaris, Marco, Salemi, Giuseppe, Solaro, Claudio, Totaro, Rocco, Trojano, Maria, Vianello, Marika, Zaffaroni, Mauro, Lepore, Vito, and Patti, Francesco
Published: 2024
Full Text: View/download PDF

2. Determinants of COVID-19-related lethality in multiple sclerosis: a meta-regression of observational studies

Author: Prosperini, Luca, Tortorella, Carla, Haggiag, Shalom, Ruggieri, Serena, Galgani, Simonetta, and Gasperini, Claudio
Published: 2022
Full Text: View/download PDF

3. Increased risk of death from COVID-19 in multiple sclerosis: a pooled analysis of observational studies

Author: Prosperini, Luca, Tortorella, Carla, Haggiag, Shalom, Ruggieri, Serena, Galgani, Simonetta, and Gasperini, Claudio
Published: 2022
Full Text: View/download PDF

4. Long-term effectiveness of natalizumab in secondary progressive multiple sclerosis: A propensity-matched study

Author: Chisari, Clara G., primary, Aguglia, Umberto, additional, Amato, Maria Pia, additional, Bergamaschi, Roberto, additional, Bertolotto, Antonio, additional, Bonavita, Simona, additional, Morra, Vincenzo Brescia, additional, Cavalla, Paola, additional, Cocco, Eleonora, additional, Conte, Antonella, additional, Cottone, Salvatore, additional, De Luca, Giovanna, additional, Di Sapio, Alessia, additional, Filippi, Massimo, additional, Gallo, Antonio, additional, Gasperini, Claudio, additional, Granella, Franco, additional, Lus, Giacomo, additional, Maimone, Davide, additional, Maniscalco, Giorgia Teresa, additional, Marfia, Girolama, additional, Moiola, Lucia, additional, Paolicelli, Damiano, additional, Pesci, Ilaria, additional, Ragonese, Paolo, additional, Rovaris, Marco, additional, Salemi, Giuseppe, additional, Solaro, Claudio, additional, Totaro, Rocco, additional, Trojano, Maria, additional, Vianello, Marika, additional, Zaffaroni, Mauro, additional, Lepore, Vito, additional, Patti, Francesco, additional, Avolio, Carlo, additional, Balgera, Roberto, additional, Banfi, Paola, additional, Bellantonio, Paolo, additional, Bramanti, Placido, additional, Capone, Lorenzo, additional, Cavalletti, Guido, additional, Chiveri, Luca, additional, Clerici, Raffaella, additional, Clerico, Marinella, additional, Corea, Francesco, additional, Dattola, Vincenzo, additional, De Robertis, Francesca, additional, Di Battista, Giancarlo, additional, Galgani, Simonetta, additional, Gatto, Maurizia, additional, Grasso, Maria Grazia, additional, Inglese, Matilde, additional, Lo Russo, Lorenzo, additional, Logullo, Francesco Ottavio, additional, Mantegazza, Renato, additional, Protti, Alessandra, additional, Rezzonico, Monica, additional, Rottoli, Mariarosa, additional, Salvetti, Marco, additional, Scarpini, Elio, additional, Sinisi, Leonardo, additional, Sparaco, Maddalena, additional, Spitaleri, Daniele, additional, Tassinari, Tiziana, additional, Tonietti, Simone, additional, Valentino, Paola, additional, Valzania, Franco, additional, and Venturi, Simonetta, additional
Published: 2024
Full Text: View/download PDF

5. Injectable Versus Oral First-Line Disease-Modifying Therapies: Results from the Italian MS Register

Author: D'Amico, Emanuele, Zanghì, Aurora, Romeo, Marzia, Cocco, Eleonora, Maniscalco, Giorgia Teresa, Brescia Morra, Vincenzo, Paolicelli, Damiano, De Luca, Giovanna, Galgani, Simonetta, Amato, Maria Pia, Salemi, Giuseppe, Inglese, Matilde, Confalonieri, Paolo Agostino, Lus, Giacomo, Avolio, Carlo, Gallo, Antonio, Vianello, Marika, Onofrj, Marco, Filippi, Massimo, Trojano, Maria, and Patti, Francesco
Published: 2021
Full Text: View/download PDF

6. Benefits of eculizumab in AQP4+ neuromyelitis optica spectrum disorder: Subgroup analyses of the randomized controlled phase 3 PREVENT trial

Author: Muñoz, Daniel Julio, Amor, Jorge David, Bocchiardo, Carolina, Danielle, Julieta Iourno, Laffue, Alfredo, Obregon, Carolina Daniela Diaz, Paez, Maria Fernanda, Perez, Roberto Martin, Rocchi, Viviana Ana Maria, Teijeiro, Loreley Deborah, Gómez, Jesica, Villa, Andres Maria, Aguirre, Florencia, Fernández, Victoria Carla, Goicoechea, Ramon F., Melamud, Luciana, Stillman, Ana, de Virgiliis, Mariana, Cassara, Fatima Pagani, Cordoba, Marta, Gutierrez, Maria Teresa, Ingolotti, Mariana, Larripa, Natalia, Lupinacci, Anahi, Arroyo, Josefina, Romano, Alejandra, Torres, Mariana Foa, Ballario, Carlos Héctor, Chiesa, Ana Elisa, Gómez, Hernán Gustavo, Lattini, Hernán Gabriel, Mainella, Carolina Natalia, Bolner, Gisel Edith, Eschoyez, María Soledad, Broadley, Simon Andrew, Heshmat, Saman, Sabet, Arman, Swayne, Andrew, Freeman, Susan, Sanchez, Sofia Jimenez, Shuey, Neil, Dalic, Linda, French, Ann, Kuma, Guru, Laing, Joshua, Law, Lai Yin, MacIntyre, Jennifer, Neal, Andrew, Plummer, Christopher, Ramachandran, Prashanth, Sedal, Leslie, Wilson, Ian, Winkel, Antony, Zhang, Wenwen, Chen, Tina, Watts, Rani, Barnett, Michael, Barton, Joshua, Beadnall, Heidi, Garber, Justin, Hardy, Todd Andrew, Trewin, Benjamin, Taha, Marinda, Walters, Deleni, Sieger, Federico Arturo Silva, Alfonso, Nhora Patricia Ruiz, Camacho, Anna Maria Pinzon, Moreno, Alexander Pabón, Prad, Jorge Armando Castellanos, Rueda, Adriana Paola Duarte, Castillo, Tatiana, Gonzalez, Karol Melissa Castillo, Pico, Martha Yolanda Moreno, Castill, Judith, Habek, Mario, Adamec, Ivan, Barun, Barbara, Crnosija, Luka, Gabelic, Tereza, Nytrova, Petra, Krasulova, Eva, Pavlickova, Jana, Tyblova, Michaela, Zubkova, Jana, Petersen, Thor, Dale, Gro Helen, Rasmussen, Peter Vestergaard, Stilund, Morten, Svendsen, Kristina Bacher, Brandt, Vivi, Collongues, Nicolas, Fleury, Marie-Celine, Kremer, Laurent, Bendele, Sandrine, Neff, Valérie, Diem, Ricarda, Platten, Michael, Berberich, Anne, Jansen, Jonabelle, Jaschoneck, Hannah, Wildemann, Brigitte, Aures, Ursula, Brandenburger, Tanja, Haut, Tanja, Fernández, Maria-Lourdes Treceno, Aly, Lilian, Brinkhoff, Kirsten, Buck, Dorothea, Golkowski, Daniel, Hermisson, Mirjam, Hoshi, Muna-Miriam, Kaminski, Miriam, Kowarik, Markus Christian, Kronsbein, Helena, Lehmann-Horn, Klaus, Pongratz, Viola Maria, Schweiker, Andreas, Leddy, Lisa-Ann, Mueller, Silvia, Obergfell, Kim, Wanka, Marion, Zettl, Uwe Klaus, Klinke, Jan, Loebermann, Micha, Meister, Stefanie, Rimmele, Florian, Winkelmann, Alexander, Schroeder, Ina, Lau, Alexander Yuk-Lun, Au, Lisa Wing-Chi, Fan, Florence Sin-Ying, Ip, Vincent Hing-Lung, Ma, Karen Ka-Yan, Ma, Sze-Ho, Mok, Vincent Chung-Tong, Au, Cheryl Chung-Kwan, Kwan, Pauline Wing-Lam, Patti, Francesco, Caramma, Andrea Salvatore, Chisari, Clara Grazia, Fermo, Salvatore Lo, Messina, Silvia, Projetto, Maria, Caserta, Cinzia, Filla, Alessandro, Costabile, Teresa, Pane, Chiara, Sacca, Francesco, Marsili, Angela, Puorro, Giorgia, Bergamaschi, Roberto, Berra, Eliana, Mallucci, Giulia, Fattore, Cinzia, Gasperini, Claudio, Galgani, Simonetta, Haggiag, Shalom, Ruggieri, Serena, Vento, Claudio, Quartuccio, Esmeralda Maria, Pozzilli, Carlo, Barletta, Valeria Teresa, Borriello, Giovanna, De Giglio, Laura, Marinelli, Fabiana, Tasillo, Miriam, Amadori, Alessandra, Fischetti, Mariano, Gurreri, Flavia, Mori, Masahiro, Masuda, Hiroki, Ohtani, Ryohei, Sekiguchi, Yukari, Uchida, Tomohiko, Uzawa, Akiyuki, Ito, Hiromi, Kabasawa, Emi, Kaneko, Yoko, Matsushita, Takuya, Matsuse, Dai, Murai, Hiroyuki, Hayashi, Shintaro, Masak, Katsuhisa, Ogata, Hidenori, Shinoda, Koji, Uehara, Taira, Watanabe, Mitsuru, Yamaguchi, Hiroo, Yamasaki, Ryo, Yonekawa, Tomomi, Jingu, Maki, Nagano, Makiko, Nakamura, Yumiko, Sano, Yoshiko, Araki, Manabu, Lin, Youwei, Mori, Madoka, Mukai, Yohei, Sano, Terunori, Sato, Wakiro, Gogun, Naoya, Maeda, Yuriko, Nishimoto, Asami, Tsukamoto, Sachiko, Yanagi, Ritsuko, Saida, Takahiko, Nakamura, Shinichi, Nasu, Tetsuya, Saida, Kyoko, Shikata, Yuko, Kodani, Yoshimi, Saeki, Megumi, Sawada, Yukako, Yoshikawa, Hiroo, Kimura, Takashi, Nishi, Masamitsu, Sakamoto, Shun, Ukon, Shinichiro, Watanabe, Shohei, Ebisuya, Saori, Kimura, Nami, Matsuura, Manami, Morisaki, Yukie, Muroi, Yoshiko, Onishi, Kuniko, Oshima, Ikuko, Washino, Yuki, Yamashita, Tomomi, Misu, Tatsuro, Kaneko, Kimihiko, Kato, Masaaki, Kuroda, Hiroshi, Kurosawa, Kazuhiro, Nishiyama, Shuhei, Ono, Hirohiko, Takai, Yoshiki, Abe, Keiko, Hoshi, Hitomi, Jinushi, Mari, Oyama, Azusa, Sakuma, Motonari, Sawada, Yuko, Ishibashi, Satoru, Yokota, Takanori, Nishida, Yoichiro, Ozaki, Kokoro, Sanjo, Nobuo, Sato, Nozomu, Denno, Fuki, Hiraki, Haruko, Matsubara, Yumi, Kanda, Takashi, Abe, Masaaki, Honda, Masaya, Kawai, Motoharu, Koga, Michiaki, Maeda, Toshihiko, Ogasawara, Junichi, Omoto, Masatoshi, Sano, Yasuteru, Sato, Ryota, Shimizu, Fumitaka, Arima, Hideki, Fukui, Sachie, Ishikawa, Yoshiko, Koyama, Tomoko, Shimose, Shigemi, Shinozaki, Hirokazu, Watanabe, Masanori, Yasuda, Sachi, Yoshiwaka, Chieko, Adenan, Suffian, Aris, Mohd Azman M, Mawardi, Ahmad Shahir bin, Adnan, Muhammad Al Hafiz, Munusamy, Nanthini, Razali, Siti Nur Omaira, Somasundram, Punitha, Hyun, Jae Won, Jeong, In Hye, Kim, Su-Hyun, Shin, Hyun-June, Yoo, Ji Sung, Jang, HyunMin, Joung, AeRan, Kim, Byung-Jo, Baek, Seol-Hee, Kim, Jung Bin, Kim, Yoo Hwan, Koo, Yong Seo, Lee, Chan Nyoung, Seok, Hung Youl, Hwang, Jinhee, Kim, Sung Min, Ahn, So Hyun, Choi, Kyomin, Choi, Seok-Jin, Kim, Jun-Soon, Kwon, Young Nam, Shin, Je-Young, Kwon, Hyeonju, Kim, Byoung Joon, Cho, Eun Bin, Cho, Hye-Jin, Choi, Misong, Kim, DongSun, Kim, Ju Hyeon, Ki, SeungJu, Lee, Hye Lim, Lee, Kwang-Ho, Min, Ju-Hong, Park, Ji-Hyung, Seok, Jinmyoung, Choi, Eunhwa, Park, Sang Ae, Kim, Seung Min, Jeong, Ha-Neul, Jeongbin, Bong, Jung, Jin Woo, Kim, Seung Woo, Kim, Yool-hee, Lee, Hyung Seok, Shin, Ha Young, Jung, Yeon, Kim, Min Jung, Lee, Nou Ri, Shin, MiJu, Khabirov, Farit A, Averyanova, Lyudmila, Babicheva, Natalya, Granatov, Eugenii, Kazarov, Sergey, Khaybullin, Timur, Rogozhin, Alexander, Pokhabov, Dmitry V, Abramov, Vladislav, Amelina, Anastasia, Nesteroca, Yulia, Bozhenkina, Tatyana, Boyko, Aleksey N, Demyan, Elena G, Khoroshilova, Inessa, Melnikov, Mikhail, Popova, Ekaterina V, Sharanova, Svetlana N, Shchur, Sergey G, Sazonov, Denis V, Babenko, Larisa, Bayandina, Elena, Yarmoschuk, Asya, Baliazin, Victor A, Baliazina, Elena, Budaeva, Elena, Chernikova, Irina, Goncharova, Zoya, Krasnov, Vladimir, Myatleva, Marina, Rodionova, Olga V., Samulyzhko, Iuliana, Timofeeva, Alla A., Duran, Sabas Boyero, Bilbao, Maria Mar Mendibe, Cuervo, Irene Diaz, Domingo, Jose Maria Losada, Eizaguirre, Amaia Gonzalez, Llona, Jose Eulalio Barcena, Moyano, Roberto Valverde, Bahamonde, Carmen, Lopez, Fernando Sanchez, Morales, Raquel Pinar, Morales, Eduardo Agüera, Roman, Carmen Bahamonde, Sepulveda, Juan Jose Ochoa, Valero, Maria del Carmen Blanco, Viña, Nazaret Pelaez, Gavilan, Cristina Conde, Sanchez, Ana Maria Jover, Bedmar, Sara Vila, Garcia, Nuria Gonzalez, Garcia, Aida Orviz, Gonzalez-Suarez, Ines, Guillamon, Elena Miñano, Kawiorski, Miguel, Schulz, Elena Guerra, Alonso, Alba Garcia, Perez, Francisco Jesus Lopez, Sarmiento, Marta Palacios, Ayuso, Guillermo Izquierdo, Mascarell, Guillermo Navarro, Camino, Cristina Paramo, Garcia, Asuncion Varas, Mendoza, Yaiza Montserrat, Muñoz, Veronica Ines Vargas, Tonda, Patricia Torres, Tsai, Ching-Piao, Yin, Jiu-Haw, Chen, Mei-Jung, Li, Shan-Ni, Wang, Fei-Ti, Srisuwannanukorn, Suwat, Boonmongkol, Thanatat, Borisutbuathip, Duangporn, Singwicha, Duangkamol, Siritanan, Krittika, Thearapati, Chidchanoke, Sornda, Kwanmuang, Apiwattanakul, Metha, Aungsumart, Saharat, Suanprasert, Narupat, Suksuchano, Kaona, Parkinsee, Nittaya, Kulkantrakorn, Kongkiat, Lolekha, Praween, Potigumjon, Artit, Sukphulloprat, Puchit, Suksasunee, Dararat, Komaratat, Chankawee, Luangtong, Sunattana, Arayawichanont, Arkhom, Konpan, Phanpaphon, Riablershirun, Nathapol, Wiroteurairuang, Thaddao, Jantaweesirirat, Panadda, Kurne, Aslı, Erkent, Irem, Kurt, Ebru Bekircan, Saylam, Ezgi, Caliskan, Yagmur, Orsel, Gulsah, Celik, Yahya, Celebi, Canan, Tekatas, Aslan, Banbal, Tugce, Demir, Gulsen Akman, Altunrende, Burcu, Matur, Zeliha, Topcular, Baris, Elmas, Tules, Gulo, Aysenur, Ozdemir, Selin, Ozkoklesen, Cansu, Ozturk, Mahinur, Yanik, Mertkan, Yildirim, Elif, Tutuncu, Melih, Altintas, Ayse, Cam, Abdulsamet, Elmali, Ayse Deniz, Saip, Sabahattin, Siva, Aksel, Tanrıverdi, Uygur, Uygunoglu, Ugur, Caliskan, Sinem, Gulo, Pinar, Kozig, Esra, Sakiz, Sakine, Sengun, Ihsan Sukru, Idiman, Egemen, Ala, Rahmi Tumay, Arslan, Duygu, Bulut, Utku, Karakaptan, Yasemin, Kaya, Derya, Mehdiyev, Zaur, Balkan, Bengu, Kuku, Berfu, Ozhun, Mujgan, Tuga, Celal, Ugur, Muzeyyen, Efendi, Husnu, Bunul, Sena Destan, Cavus, Hakan, Gorke, Yunus Emre, Kutlu, Ayse, Ozturk, Seda, Sarikaya, Cansu Egilmez, Becerikli, Gulsah, Semiz, Cansu, Tun, Ozlem, Ayer, Sehriban, Onar, Musa Kazim, Ozberk, Mehlika Berra, Sen, Sedat, Cavdar, Tugce Kirbas, Veske, Adife, Boz, Cavit, Altiparmak, Didem, Aydin, Cigdem Ozen, Gazioglu, Sibel, Bekircan, Duygu, Jacob, Anu, Arndt, Heike, Elsone, Liene, Hamid, Shahd Hassan Mahmoud, Whittam, Daniel Hugh, Wilson, Martin, O'Brien, Imelda, Leite, Maria Isabel da Silva, Cruz, Pedro Maria Rodriguez, Jenkins, Damian Robert, Tackley, George, Cavey, Ana, Everett, Rosie, Hodder, Joy, Koelewyn, Abigail, Mowry, Ellen, Royal, Walter, III, Shin, Robert, Bever, Christopher, Jr, Harrison, Daniel, Rus, Horea, Zheng, Wei, Callison, Karen, Naunton, Kerry, Frishberg, Benjamin M, Blumenfeld, Andrew M, Inocelda, Andrew, Korabathina, Kalyani, Lobatz, Michael, Mortin, Melissa M, Oh, Irene J, Rosenberg, Jay H, Sadoff, Mark, Sahagian, Gregory A, Wang, Anchi, Camberos, Yasmin, Sanchez, Guadalupe, Soto, Estela, Nicholas, Jacqueline A, Boster, Aaron, Eubank, Geoffrey, Groezinger, Katy, Lauf, Meghan, Okai, Annette F, Hasan, Rashedul, Khoury, Chaouki, Stokes, Victoria, Clardy, Stacey, Cortez, Melissa, Greenlee, John, Rose, John, Soldan, Mateo Paz, Emett, Amanda, Esquibel, Lawanda, Fagatele, Lilly, Wong, Ka-Ho, Stevens, James C, Banas, Thomas M, Bultemeyer, Marlene C, Haller, Andrea, Manalo, Natalie, Aeschliman, Keri, Kocks, Debi, Racke, Michael, Boster, Aaron Lee, Bowman, Michelle, Imitola, Jaime, Kisanuki, Yasushi, Green, Misty, Scarberry, Stephanie, Lynch, Sharon G, Anderson, Heather S, Gronseth, Gary S, Hammond, Nancy E, Jassam, Yasir N, Mittal, Manoj K, Nashatizadeh, Muhammed M, Levine, Nicholas, Schmidt, Lisa, Sibley, Jill, Whitley, Vonda, Winkley, James, Coleman, Timothy, Cooper, Gregory, Sheffield, Stephanie, Turner, Keri, Galloway, Dana, Tillett, Robert S, Jr, Ganesh, Geeta A, Plato, Brian M, Seifert, Tad D, Godwin, Diana, Lockridge, Deborah, Rammohan, Kottil W, Sheremata, William A, Delgado, Silvia, Gonzalez, Jose, Lizarraga, Alexis, Maldonado, Janice, Ortega, Melissa, Tornes, Leticia, Babcock, Yanet, Cailam, Osmara, Campos, Yesica, Couvertier, Irlisse, Daneri, Bettina, Deni, Jeremy, Hernandez, Jeffrey, Jaramillo, Tatiana, Morris, Tenita, Nobel, Daniel, Oliveira, Anjelis, Richardson, Reshma, Rodriguez, Gloria, Romero, Ana, Sandova, Carlos, Sawant, Ruta, Tueros, Lissett, Zetka, Eric S, Zheng, Chao, Jacobs, Daniel H, Easterling, Constance, Fairbank, Jennifer, Iyengar, Revathi, Klafter, Mark, Lindquist, Justin, Sadek, Ahmed H, Toro, Elizabeth Carmona, Verma, Navin, Castro, Brigith Patino, Sukhraj-Singh, Nadia, Berger, Joseph, Williamson, Eric, Chahin, Salim, Jacobs, Dina, Markowitz, Clyde, Dobbins, Jessica, Mace, Lauren, Martin, Maria, Pinckney, Ashley, Roberts, Amber, Zaydan, Islam, Mitchell, Galen W, Heyman, Rock A, Orie, Ryan L, Suski, Valerie R, Oddis, Kerry, Punjack, Darlene, Flanagan, Eoin, Gadoth, Avi, McKeon, Andrew, Tobin, W Oliver, Zekeridou, Anastasia, Dunlay, Katie, Sagen, Jessica, Carter, Jonathan L, Estephan, Bachir, Goodman, Brent P, Snyder, Charlene R Hoffman, Francone, Andrea, Galasky, Irene, Thomas, Martha, Repovic, Pavle, Bowen, James, Mayadev, Angeli, Qian, Peiqing, Courtney, Yuriko, Lennox, Lauren, Naismith, Robert Thomas, Cross, Anne Haney, Evans, Emily, Longbrake, Erin E, Orchard, Megan E, Wu, Gregory F, Heinrich, Linda, Sommers, Susan, Amjad, Faria, Mitchell, Erika, Mora, Carlos, Schreiber, Bethany, Tornatore, Carlo, Carlson, Alexis, McCarthy, Sacha, Oliver, Alexandria, Palace, Jacqueline, Wingerchuk, Dean M., Fujihara, Kazuo, Berthele, Achim, Oreja-Guevara, Celia, Kim, Ho Jin, Nakashima, Ichiro, Levy, Michael, Terzi, Murat, Totolyan, Natalia, Viswanathan, Shanthi, Wang, Kai-Chen, Pace, Amy, Yountz, Marcus, Miller, Larisa, Armstrong, Róisín, and Pittock, Sean
Published: 2021
Full Text: View/download PDF

7. Estimating the Prevalence of Cognitive Impairment and Its Associated Factors in Albania: A Nationwide Cross-Sectional Study.

Author: Hoxha, Malvina, Galgani, Simonetta, Kruja, Jera, Alimehmeti, Ilir, Rapo, Viktor, Çipi, Frenki, Tricarico, Domenico, and Zappacosta, Bruno
Subjects: *MEDICAL personnel, *MILD cognitive impairment, *COGNITION disorders, *DEMENTIA, *CEREBRAL ischemia
Abstract: Background/Objectives: Cognitive impairment is an intermediate state between normal aging and dementia, and its detection in the early stages is essential to prevent dementia, an incurable pathology. The aim of this study is to screen and estimate the prevalence of cognitive impairment, including dementia, and its correlated factors in a community-based sample of the Albanian population over 50 years old. Methods: We carried out a door-to-door neuropsychological screening of Albanian residents older than 50 years from November 2023 to June 2024 in 12 Albanian districts. Participants completed the Early Dementia Questionnaire (EDQ) and the Mini Mental State Examination (MMSE). Results: The overall estimating prevalence of cognitive impairment and early dementia among the Albanian population over 50 years old was 14.04% using the MMSE, with 2.31% for MMSE ≤18 (serious cognitive impairment), 5.51% for MMSE 19–22 (mild cognitive impairment (MCI)), and 6.22 for MMSE 23–24 (suspected cognitive impairment or dementia),respectively. The prevalence of early dementia using the EDQ was significantly higher (53.99%).The number of male participants with MMSE scores of 23–24 (suspected cognitive impairment or early dementia) was 2.5 times higher with respect to female participants. Smoking and alcohol consumption decreased the MMSE scores. The number of participants with normal cognitive function (MMSE scores 25–30) was lower among participants with hypertension, diabetes, hyperlipidemia, and cerebral ischemia. Conclusions: A diagnostic evaluation, including a clinical examination, neuroimaging, and laboratory studies, is further required for a diagnosis. Despite limitations, the data provided in this study are the only ones reported for a large community-based sample of the older adult Albanian population, which can help health care providers to diagnose cognitive impairment. [ABSTRACT FROM AUTHOR]
Published: 2024
Full Text: View/download PDF

8. Anti-RBD Antibody Levels and IFN-γ-Specific T Cell Response Are Associated with a More Rapid Swab Reversion in Patients with Multiple Sclerosis after the Booster Dose of COVID-19 Vaccination.

Author: Aiello, Alessandra, Ruggieri, Serena, Navarra, Assunta, Tortorella, Carla, Vanini, Valentina, Haggiag, Shalom, Prosperini, Luca, Cuzzi, Gilda, Salmi, Andrea, Quartuccio, Maria Esmeralda, Altera, Anna Maria Gerarda, Meschi, Silvia, Matusali, Giulia, Vita, Serena, Galgani, Simonetta, Maggi, Fabrizio, Nicastri, Emanuele, Gasperini, Claudio, and Goletti, Delia
Subjects: BOOSTER vaccines, BREAKTHROUGH infections, COVID-19 vaccines, ANTIBODY formation, T cells
Abstract: This study investigated the incidence and severity of SARS-CoV-2 breakthrough infections (BIs) and the time to swab reversion in patients with multiple sclerosis (PwMS) after the booster dose of COVID-19 mRNA vaccines. We enrolled 64 PwMS who had completed the three-dose mRNA vaccine schedule and had never experienced COVID-19 before. Among the 64 PwMS, 43.8% had BIs with a median time since the third vaccine dose of 155 days. BIs occurred more frequently in ocrelizumab-treated patients (64.7%). Patients with a relapsing-remitting MS course showed a reduced incidence of BIs compared with those with a primary-progressive disease (p = 0.002). Having anti-receptor-binding domain (RBD) antibodies represented a protective factor reducing the incidence of BIs by 60% (p = 0.042). The majority of BIs were mild, and the only severe COVID-19 cases were reported in patients with a high Expanded Disability Status Scale score (EDSS > 6). The median time for a negative swab was 11 days. Notably, fingolimod-treated patients take longer for a swab-negativization (p = 0.002). Conversely, having anti-RBD antibodies ≥ 809 BAU/mL and an IFN-γ-specific T cell response ≥ 16 pg/mL were associated with a shorter time to swab-negativization (p = 0.051 and p = 0.018, respectively). In conclusion, the immunological protection from SARS-CoV-2 infection may differ among PwMS according to DMTs. [ABSTRACT FROM AUTHOR]
Published: 2024
Full Text: View/download PDF

9. Induction Versus Escalation in Multiple Sclerosis: A 10-Year Real World Study

Author: Prosperini, Luca, Mancinelli, Chiara Rosa, Solaro, Claudio Marcello, Nociti, Viviana, Haggiag, Shalom, Cordioli, Cinzia, De Giglio, Laura, De Rossi, Nicola, Galgani, Simonetta, Rasia, Sarah, Ruggieri, Serena, Tortorella, Carla, Capra, Ruggero, Mirabella, Massimiliano, and Gasperini, Claudio
Published: 2020
Full Text: View/download PDF

10. Injectable Versus Oral First-Line Disease-Modifying Therapies: Results from the Italian MS Register

Author: D’Amico, Emanuele, Zanghì, Aurora, Romeo, Marzia, Cocco, Eleonora, Maniscalco, Giorgia Teresa, Brescia Morra, Vincenzo, Paolicelli, Damiano, De Luca, Giovanna, Galgani, Simonetta, Amato, Maria Pia, Salemi, Giuseppe, Inglese, Matilde, Confalonieri, Paolo Agostino, Lus, Giacomo, Avolio, Carlo, Gallo, Antonio, Vianello, Marika, Onofrj, Marco, Filippi, Massimo, Trojano, Maria, and Patti, Francesco
Published: 2021
Full Text: View/download PDF

11. Exit strategies for “needle fatigue” in multiple sclerosis: a propensity score-matched comparison study

Author: Prosperini, Luca, Cortese, Antonio, Lucchini, Matteo, Boffa, Laura, Borriello, Giovanna, Buscarinu, Maria Chiara, Capone, Fioravante, Centonze, Diego, De Fino, Chiara, De Pascalis, Daniela, Fantozzi, Roberta, Ferraro, Elisabetta, Filippi, Maria, Galgani, Simonetta, Gasperini, Claudio, Haggiag, Shalom, Landi, Doriana, Marfia, Girolama, Mataluni, Giorgia, Millefiorini, Enrico, Mirabella, Massimiliano, Monteleone, Fabrizia, Nociti, Viviana, Pontecorvo, Simona, Romano, Silvia, Ruggieri, Serena, Salvetti, Marco, Tortorella, Carla, Zannino, Silvana, and Di Battista, Giancarlo
Published: 2020
Full Text: View/download PDF

12. Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study

Author: Achiron, Anat, Achtnichts, Lutz, Agan, Kadriye, Akman-Demir, Gulsen, Allen, Alison B, Antel, Jack P, Antiguedad, Alfredo Rodriguez, Apperson, Michelle, Applebee, Angela M, Ayuso, Guillermo Izquierdo, Baba, Masayuki, Bajenaru, Ovidiu, Balasa, Rodica, Balci, Belgin Petek, Barnett, Michael, Bass, Ann, Becker, Veit U, Bejinariu, Mihaela, Bergh, Florian Then, Bergmann, Arnfin, Bernitsas, Evanthia, Berthele, Achim, Bhan, Virender, Bischof, Felix, Bjork, Randall John, Blevins, Gregg, Boehringer, Matthias, Boerner, Thomas, Bonek, Robert, Bowen, James D, Bowling, Allen, Boyko, Alexey N, Boz, Cavit, Bracknies, Vera, Braune, Stefan, Brescia Morra, Vincenzo, Brochet, Bruno, Brola, Waldemar, Brownstone, Paul Kenneth, Brozman, Miroslav, Brunet, Donald, Buraga, Ioan, Burnett, Margaret, Buttmann, Mathias, Butzkueven, Helmut, Cahill, Jonathan, Calkwood, Jonathan C, Camu, William, Cascione, Mark, Castelnovo, Giovani, Centonze, Diego, Cerqueira, Joao, Chan, Andrew, Cimprichova, Andrea, Cohan, Stanley, Comi, Giancarlo, Conway, Jill, Cooper, Joanna A, Corboy, John, Correale, Jorge, Costell, Brian, Cottrell, David A, Coyle, Patricia K, Craner, Matthew, Cui, Liying, Cunha, Luis, Czlonkowska, Anna, da Silva, Ana Martins, de Sa, Joao, de Seze, Jérôme, Debouverie, Marc, Debruyne, Jan, Decoo, Danny, Defer, Gilles, Derfuss, Tobias, Deri, Norma H, Dihenia, Bhupesh, Dioszeghy, Peter, Donath, Vladimir, Dubois, Benedicte, Duddy, Martin, Duquette, Pierre, Edan, Gilles, Efendi, Husnu, Elias, Stanton, Emrich, Peter J, Estruch, Bonaventura Casanova, Evdoshenko, Evgeniy P, Faiss, Juergen, Fedyanin, Alexander S, Feneberg, Wolfgang, Fermont, Jiske, Fernandez, Oscar Fernandez, Ferrer, Francisco Coret, Fink, Katharina, Ford, Helen, Ford, Corey, Francia, Ada, Freedman, Mark, Frishberg, Benjamin, Galgani, Simonetta, Garmany, George P, Gehring, Klaus, Gitt, Jeffrey, Gobbi, Claudio, Goldstick, Lawrence P, Gonzalez, Rafael Arroyo, Grandmaison, Francois, Grigoriadis, Nikolaos, Grigorova, Olga, Grimaldi, Luigi Maria Edoardo, Gross, Jeffrey, Gross-Paju, Katrin, Gudesblatt, Mark, Guillaume, Daniel, Haas, Judith, Hancinova, Viera, Hancu, Anca, Hardiman, Orla, Harmjanz, Arndt, Heidenreich, Fedor R, Hengstman, G J D, Herbert, Joseph, Herring, Mark, Hodgkinson, Suzanne, Hoffmann, Olaf M, Hofmann, Werner E, Honeycutt, William D, Hua, Le Hanh, Huang, Dehui, Huang, Yining, Huang, DeRen, Hupperts, Raymond, Imre, Piroska, Jacobs, Alan Keith, Jakab, Gabor, Jasinska, Elzbieta, Kaida, Kenichi, Kalnina, Jolanta, Kaprelyan, Ara, Karelis, Guntis, Karussis, Dimitrios, Katz, Amos, Khabirov, Farit A, Khatri, Bhupendra, Kimura, Takashi, Kister, Ilya, Kizlaitiene, Rasa, Klimova, Eleonora, Koehler, Juergen, Komatineni, Aparna, Kornhuber, Anselm, Kovacs, Krisztina, Koves, Agnes, Kozubski, Wojciech, Krastev, Georgi, Krupp, Lauren B, Kurca, Egon, Lassek, Christoph, Laureys, Guy, Lee, Liesly, Lensch, Eckart, Leutmezer, Fritz, Li, Hongzeng, Linker, Ralf A, Linnebank, Michael, Liskova, Petra, Llanera, Cristina, Lu, Jiahong, Lutterotti, Andreas, Lycke, Jan, Macdonell, Richard, Maciejowski, Maciej, Maeurer, Mathias, Magzhanov, Rim V, Maida, Eva-Maria, Malciene, Lina, Mao-Draayer, Yang, Marfia, Girolama Alessandra, Markowitz, Clyde, Mastorodimos, Vasileios, Matyas, Klotild, Meca-Lallana, Jose, Merino, Juan Antonio Garcia, Mihetiu, Ioan Gheorghe, Milanov, Ivan, Miller, Aaron E, Millers, Andrejs, Mirabella, Massimiliano, Mizuno, Masanori, Montalban, Xavier, Montoya, Lilina, Mori, Masahiro, Mueller, Stefanie, Nakahara, Jin, Nakatsuji, Yuji, Newsome, Scott, Nicholas, Richard, Nielsen, A Scott, Nikfekr, Esmaeil, Nocentini, Ugo, Nohara, Chiyoko, Nomura, Kyoichi, Odinak, Miroslav M, Olsson, Tomas, van Oosten, B W, Oreja-Guevara, Celia, Oschmann, Patrick, Overell, James, Pachner, Andrew, Panczel, Gyula, Pandolfo, Massimo, Papeix, Caroline, Patrucco, Liliana, Pelletier, Jean, Piedrabuena, Raul, Pless, Misha, Polzer, Udo, Pozsegovits, Krisztian, Rastenyte, Daiva, Rauer, Sebastian, Reifschneider, Gerd, Rey, Roberto, Rizvi, Syed A, Robertson, Derrick, Rodriguez, Jose Martinez, Rog, David, Roshanisefat, Homayoun, Rowe, Vernon, Rozsa, Csilla, Rubin, Susan, Rusek, Stanislaw, Saccà, Francesco, Saida, Takahiko, Salgado, Antonio Vasco, Sanchez, Victoria Eugenia Fernandez, Sanders, Kalina, Satori, Maria, Sazonov, Denis V, Scarpini, Elio Angelo, Schlegel, Eugen, Schluep, Myriam, Schmidt, Stephan, Scholz, Erich, Schrijver, H M, Schwab, Matthias, Schwartz, Raymond, Scott, James, Selmaj, Krzysztof, Shafer, Stuart, Sharrack, Basil, Shchukin, Ivan A, Shimizu, Yuko, Shotekov, Penko, Siever, Arno, Sigel, Karl-Otto, Silliman, Scott, Simo, Magdolna, Simu, Mihaela, Sinay, Vladimiro, Siquier, Antonio Escartin, Siva, Aksel, Skoda, Ondrej, Solomon, Andrew, Stangel, Martin, Stefoski, Dusan, Steingo, Brian, Stolyarov, Igor D, Stourac, Pavel, Strassburger-Krogias, Katrin, Strauss, Erik, Stuve, Olaf, Tarnev, Ivaylo, Tavernarakis, Antonios, Tello, Cristina Ramo, Terzi, Murat, Ticha, Veronika, Ticmeanu, Marina, Tiel-Wilck, Klaus, Toomsoo, Toomas, Tubridy, Niall, Tullman, Mark J, Tumani, Hayrettin, Turcani, Peter, Turner, Ben, Uccelli, Antonio, Urtaza, Francisco Javier Olascoaga, Vachova, Marta, Valikovics, Attila, Walter, Silke, Van Wijmeersch, Bart, Vanopdenbosch, Ludo, Weber, Joerg R, Weiss, Sara, Weissert, Robert, Vermersch, Patrick, West, Timothy, Wiendl, Heinz, Wiertlewski, Sandrine, Wildemann, Brigitte, Willekens, Barbara, Visser, L H, Vorobeychik, Galina, Xu, Xianhao, Yamamura, Takashi, Yang, Yi N, Yelamos, Sergio Martinez, Yeung, Michael, Zacharias, Alan, Zelkowitz, Marvin, Zettl, Uwe, Zhang, Meini, Zhou, Hongyu, Zieman, Ulf, Ziemssen, Tjalf, Kappos, Ludwig, Bar-Or, Amit, Cree, Bruce A C, Fox, Robert J, Giovannoni, Gavin, Gold, Ralf, Arnold, Douglas L, Arnould, Sophie, Scherz, Tatiana, Wolf, Christian, Wallström, Erik, and Dahlke, Frank
Published: 2018
Full Text: View/download PDF

13. Dynamic Evolution of Humoral and T-Cell Specific Immune Response to COVID-19 mRNA Vaccine in Patients with Multiple Sclerosis Followed until the Booster Dose

Author: Ruggieri, Serena, primary, Aiello, Alessandra, additional, Tortorella, Carla, additional, Navarra, Assunta, additional, Vanini, Valentina, additional, Meschi, Silvia, additional, Lapa, Daniele, additional, Haggiag, Shalom, additional, Prosperini, Luca, additional, Cuzzi, Gilda, additional, Salmi, Andrea, additional, Quartuccio, Maria Esmeralda, additional, Altera, Anna Maria Gerarda, additional, Garbuglia, Anna Rosa, additional, Ascoli Bartoli, Tommaso, additional, Galgani, Simonetta, additional, Notari, Stefania, additional, Agrati, Chiara, additional, Puro, Vincenzo, additional, Nicastri, Emanuele, additional, Gasperini, Claudio, additional, and Goletti, Delia, additional
Published: 2023
Full Text: View/download PDF

14. Real-world effectiveness of natalizumab and fingolimod compared with self-injectable drugs in non-responders and in treatment-naïve patients with multiple sclerosis

Author: Prosperini, Luca, Saccà, Francesco, Cordioli, Cinzia, Cortese, Antonio, Buttari, Fabio, Pontecorvo, Simona, Bianco, Assunta, Ruggieri, Serena, Haggiag, Shalom, Brescia Morra, Vincenzo, Capra, Ruggero, Centonze, Diego, Di Battista, Giancarlo, Ferraro, Elisabetta, Francia, Ada, Galgani, Simonetta, Gasperini, Claudio, Millefiorini, Enrico, Mirabella, Massimiliano, and Pozzilli, Carlo
Published: 2017
Full Text: View/download PDF

15. Longitudinal characterisation of B and T-cell immune responses after the booster dose of COVID-19 mRNA-vaccine in people with multiple sclerosis using different disease-modifying therapies

Author: Aiello, Alessandra, primary, Coppola, Andrea, additional, Ruggieri, Serena, additional, Farroni, Chiara, additional, Altera, Anna Maria Gerarda, additional, Salmi, Andrea, additional, Vanini, Valentina, additional, Cuzzi, Gilda, additional, Petrone, Linda, additional, Meschi, Silvia, additional, Lapa, Daniele, additional, Bettini, Aurora, additional, Haggiag, Shalom, additional, Prosperini, Luca, additional, Galgani, Simonetta, additional, Quartuccio, Maria Esmeralda, additional, Bevilacqua, Nazario, additional, Garbuglia, Anna Rosa, additional, Agrati, Chiara, additional, Puro, Vincenzo, additional, Tortorella, Carla, additional, Gasperini, Claudio, additional, Nicastri, Emanuele, additional, and Goletti, Delia, additional
Published: 2022
Full Text: View/download PDF

16. Fingolimod vs dimethyl fumarate in multiple sclerosis: A real-world propensity score-matched study

Author: Prosperini, Luca, Lucchini, Matteo, Haggiag, Shalom, Bellantonio, Paolo, Bianco, Assunta, Buscarinu, Maria Chiara, Buttari, Fabio, Centonze, Diego, Cortese, Antonio, De Giglio, Laura, Fantozzi, Roberta, Ferraro, Elisabetta, Fornasiero, Arianna, Francia, Ada, Galgani, Simonetta, Gasperini, Claudio, Marfia, Girolama Alessandra, Millefiorini, Enrico, Nociti, Viviana, Pontecorvo, Simona, Pozzilli, Carlo, Ruggieri, Serena, Salvetti, Marco, Sgarlata, Eleonora, and Mirabella, Massimiliano
Published: 2018
Full Text: View/download PDF

17. Relapse‐associated worsening in a real‐life multiple sclerosis cohort: the role of age and pyramidal phenotype.

Author: Zanghì, Aurora, Galgani, Simonetta, Bellantonio, Paolo, Zaffaroni, Mauro, Borriello, Giovanna, Inglese, Matilde, Romano, Silvia, Conte, Antonella, Patti, Francesco, Trojano, Maria, Avolio, Carlo, and D'Amico, Emanuele
Subjects: *MULTIPLE sclerosis, *PHENOTYPES, *ODDS ratio, *CONFIDENCE intervals, *AGE
Abstract: Background and purpose: The overall disability in patients with relapsing–remitting multiple sclerosis is likely to be partly rather than entirely attributed to relapse. Materials and methods: The aim was to investigate the determinants of recovery from first relapse and relapse‐associated worsening (RAW) in relapsing–remitting multiple sclerosis patients from the Italian MS Registry during a 5‐year epoch from the beginning of first‐line disease‐modifying therapy. To determine recovery, the functional system (FS) score was used to calculate the difference between the score on the date of maximum improvement and the score before the onset of relapse. Incomplete recovery was defined as a combination of partial (1 point in one FS) and poor recovery (2 points in one FS or 1 point in two FSs or any other higher combination). RAW was indicated by a confirmed disability accumulation measured by the Expanded Disability Status Scale score confirmed 6 months after the first relapse. Results: A total of 767 patients had at least one relapse within 5 years of therapy. Of these patients, 57.8% experienced incomplete recovery. Age (odds ratio [OR] 1.02, 95% confidence interval [CI] 1.01–1.04; p = 0.007) and pyramidal phenotype were associated with incomplete recovery (OR = 2.1, 95% CI 1.41–3.14; p < 0.001). RAW was recorded in 179 (23.3%) patients. Age (OR = 1.02, 95% CI 1.01–1.04; p = 0.029) and pyramidal phenotype (OR = 1.84, 95% CI 1.18–2.88; p = 0.007) were the strongest predictors in the multivariable model. Conclusions: Age and pyramidal phenotype were the strongest determinants of RAW in early disease epochs. [ABSTRACT FROM AUTHOR]
Published: 2023
Full Text: View/download PDF

18. Prevalence of multiple sclerosis in the Lazio region, Italy: use of an algorithm based on health information systems

Author: Bargagli, Anna Maria, Colais, Paola, Agabiti, Nera, Mayer, Flavia, Buttari, Fabio, Centonze, Diego, Di Folco, Marta, Filippini, Graziella, Francia, Ada, Galgani, Simonetta, Gasperini, Claudio, Giuliani, Manuela, Mirabella, Massimiliano, Nociti, Viviana, Pozzilli, Carlo, and Davoli, Marina
Published: 2016
Full Text: View/download PDF

19. Hematopoietic Stem Cell Transplantation in People With Active Secondary Progressive Multiple Sclerosis

Author: Boffa, Giacomo, Signori, Alessio, Massacesi, Luca, Mariottini, Alice, Sbragia, Elvira, Cottone, Salvatore, Amato, Maria Pia, Gasperini, Claudio, Moiola, Lucia, Meletti, Stefano, Repice, Anna Maria, Brescia Morra, Vincenzo, Salemi, Giuseppe, Patti, Francesco, Filippi, Massimo, De Luca, Giovanna, Lus, Giacomo, Zaffaroni, Mauro, Sola, Patrizia, Conte, Antonella, Nistri, Riccardo, Aguglia, Umberto, Granella, Franco, Galgani, Simonetta, Caniatti, Luisa Maria, Lugaresi, Alessandra, Romano, Silvia, Iaffaldano, Pietro, Cocco, Eleonora, Saccardi, Riccardo, Angelucci, Emanuele, Trojano, Maria, Mancardi, Giovanni Luigi, Sormani, Maria Pia, Inglese, Matilde, Capobianco, Marco, Zimatore, Giovanni Bosco, Frau, Jessica, Scarpini, Elio, Meucci, Giuseppe, Guidetti, Donata, Gualandi, Francesca, Varaldo, Riccardo, Raiola, Anna Maria, Innocenti, Chiara, Zoli, Valerio, Ciceri, Fabio, Greco, Raffaella, Scim`e, Rosanna, De Gobbi, Marco, Barilaro, Alessandro, Boffa, Giacomo, Signori, Alessio, Massacesi, Luca, Mariottini, Alice, Sbragia, Elvira, Cottone, Salvatore, Amato, Maria Pia, Gasperini, Claudio, Moiola, Lucia, Meletti, Stefano, Repice, Anna Maria, Brescia Morra, Vincenzo, Salemi, Giuseppe, Patti, Francesco, Filippi, Massimo, De Luca, Giovanna, Lus, Giacomo, Zaffaroni, Mauro, Sola, Patrizia, Conte, Antonella, Nistri, Riccardo, Aguglia, Umberto, Granella, Franco, Galgani, Simonetta, Caniatti, Luisa Maria, Lugaresi, Alessandra, Romano, Silvia, Iaffaldano, Pietro, Cocco, Eleonora, Saccardi, Riccardo, Angelucci, Emanuele, Trojano, Maria, Mancardi, Giovanni Luigi, Sormani, Maria Pia, and Inglese, Matilde
Subjects: Hematopoietic Stem Cell Transplantation, Active Secondary Progressive Multiple Sclerosis, Neurology (clinical), Research Article
Abstract: Background and ObjectivesUncontrolled evidence suggests that autologous hematopoietic stem cell transplantation (AHSCT) can be effective in people with active secondary progressive multiple sclerosis (SPMS). In this study, we compared the effect of AHSCT with that of other anti-inflammatory disease-modifying therapies (DMTs) on long-term disability worsening in active SPMS.MethodsWe collected data from the Italian Bone Marrow Transplantation Study Group and the Italian Multiple Sclerosis Register. Patients were considered eligible if treatment had been started after the diagnosis of SPMS. Disability worsening was assessed by the cumulative proportion of patients with a 6-month confirmed disability progression (CDP) according to the Expanded Disability Status Scale (EDSS) score. Key secondary endpoints were the EDSS time trend after treatment start and the prevalence of disability improvement over time. Time to first CDP was assessed by means of proportional hazard Cox regression models. A linear mixed model with a time × treatment group interaction was used to assess the longitudinal EDSS time trends. Prevalence of improvement was estimated using a modified Kaplan-Meier estimator and compared between groups by bootstrapping the area under the curve.ResultsSeventy-nine AHSCT-treated patients and 1975 patients treated with other DMTs (beta interferons, azathioprine, glatiramer-acetate, mitoxantrone, fingolimod, natalizumab, methotrexate, teriflunomide, cyclophosphamide, dimethyl fumarate, and alemtuzumab) were matched to reduce treatment selection bias using propensity score and overlap weighting approaches. Time to first CDP was significantly longer in transplanted patients (hazard ratio [HR] = 0.50; 95% CI = 0.31–0.81;p= 0.005), with 61.7% of transplanted patients free from CPD at 5 years. Accordingly, EDSS time trend over 10 years was higher in patients treated with other DMTs than in AHSCT-treated patients (+0.157 EDSS points per year compared with −0.013 EDSS points per year; interactionp< 0.001). Patients who underwent AHSCT were more likely to experience a sustained disability improvement: 34.7% of patients maintained an improvement (a lower EDSS than baseline) 3 years after transplant vs 4.6% of patients treated by other DMTs (p< 0.001).DiscussionThe use of AHSCT in people with active SPMS is associated with a slowing of disability progression and a higher likelihood of disability improvement compared with standard immunotherapy.Classification of EvidenceThis study provides Class III evidence that autologous hematopoietic stem cell transplants prolonged the time to CDP compared with other DMTs.
Published: 2022

20. Early transient asymptomatic neutropenia associated with alemtuzumab treatment in multiple sclerosis: a case report

Author: Galgani, Simonetta, Prosperini, Luca, Haggiag, Shalom, Tortorella, Carla, and Gasperini, Claudio
Published: 2018
Full Text: View/download PDF

21. Longitudinal characterisation of B and T-cell immune responses after the booster dose of COVID-19 mRNA-vaccine in people with multiple sclerosis using different disease-modifying therapies.

Author: Aiello, Alessandra, Coppola, Andrea, Ruggieri, Serena, Farroni, Chiara, Gerarda Altera, Anna Maria, Salmi, Andrea, Vanini, Valentina, Cuzzi, Gilda, Petrone, Linda, Meschi, Silvia, Lapa, Daniele, Bettini, Aurora, Haggiag, Shalom, Prosperini, Luca, Galgani, Simonetta, Quartuccio, Maria Esmeralda, Bevilacqua, Nazario, Garbuglia, Anna Rosa, Agrati, Chiara, and Puro, Vincenzo
Subjects: BOOSTER vaccines, MEDICAL personnel, MULTIPLE sclerosis, IMMUNE response, HEALTH services administration, HIV seroconversion
Published: 2023
Full Text: View/download PDF

22. Increased risk of death from COVID-19 in multiple sclerosis: A meta-analysis of observational studies

Author: Prosperini, Luca, Tortorella, Carla, Haggiag, Shalom, Ruggieri, Serena, Galgani, Simonetta, and Gasperini, Claudio
Published: 2021
Full Text: View/download PDF

23. Zika virus infection in the central nervous system and female genital tract

Author: Nicastri, Emanuele, Castilletti, Concetta, Balestra, Pietro, Galgani, Simonetta, and Ippolito, Giuseppe
Subjects: Health
Abstract: To the Editor: On April 9, 2016, a 32-year-old woman from Italy traveled to Santo Domingo in the Dominican Republic. She worked as a volunteer nurse in the outpatient clinic [...]
Published: 2016

24. Increased risk of death from COVID-19 in multiple sclerosis: a pooled analysis of observational studies

Author: Prosperini, Luca, primary, Tortorella, Carla, additional, Haggiag, Shalom, additional, Ruggieri, Serena, additional, Galgani, Simonetta, additional, and Gasperini, Claudio, additional
Published: 2021
Full Text: View/download PDF

25. Hematopoietic Stem Cell Transplantation in People With Active Secondary Progressive Multiple Sclerosis

Author: Boffa, Giacomo, Signori, Alessio, Massacesi, Luca, Mariottini, Alice, Sbragia, Elvira, Cottone, Salvatore, Amato, Maria Pia, Gasperini, Claudio, Moiola, Lucia, Meletti, Stefano, Repice, Anna Maria, Brescia Morra, Vincenzo, Salemi, Giuseppe, Patti, Francesco, Filippi, Massimo, De Luca, Giovanna, Lus, Giacomo, Zaffaroni, Mauro, Sola, Patrizia, Conte, Antonella, Nistri, Riccardo, Aguglia, Umberto, Granella, Franco, Galgani, Simonetta, Caniatti, Luisa Maria, Lugaresi, Alessandra, Romano, Silvia, Iaffaldano, Pietro, Cocco, Eleonora, Saccardi, Riccardo, Angelucci, Emanuele, Trojano, Maria, Mancardi, Giovanni Luigi, Sormani, Maria Pia, Inglese, Matilde, Capobianco, Marco, Zimatore, Giovanni Bosco, Frau, Jessica, Scarpini, Elio, Meucci, Giuseppe, Guidetti, Donata, Gualandi, Francesca, Varaldo, Riccardo, Raiola, Anna Maria, Innocenti, Chiara, Zoli, Valerio, Ciceri, Fabio, Greco, Raffaella, Scim`e, Rosanna, De Gobbi, Marco, and Barilaro, Alessandro
Published: 2023
Full Text: View/download PDF

26. Persistence of neuropsychologic deficits despite long-term highly active antiretroviral therapy in patients with HIV-related neurocognitive impairment

Author: Tozzi, Valerio, Balestra, Pietro, Bellagamba, Rita, Corpolongo, Angela, Salvatori, Maria Flora, Visco-Comandini, Ubaldo, Vlassi, Chrysoula, Giudianelli, Marinella, Galgani, Simonetta, Antinori, Andrea, and Narciso, Pasquale
Subjects: Highly active antiretroviral therapy -- Health aspects, HIV patients -- Psychological aspects, HIV patients -- Health aspects, Health
Abstract: The prevalence and predictors of persistent neuro psychologic (NP) deficits despite long-term highly active antiretroviral therapy (HAART) in patients with HIV-related neurocognitive impairment (NCI) are assessed. It is observed that 59 percent of the patients had persistent NP deficits.
Published: 2007

27. Prevalence and risk factors for human immunodeficiency virus-associated neurocognitive impairment, 1996 to 2002: Results from an urban observational cohort

Author: Tozzi, Valerio, Balestra, Pietro, Lorenzini, Patrizia, Bellagamba, Rita, Galgani, Simonetta, Corpolongo, Angela, Vlassi, Chrysoula, Larussa, Dora, Zaccarelli, Mauro, Noto, Pasquale, Visco-Comandini, Ubaldo, Giulianelli, Marinella, Ippolito, Giuseppe, Antinori, Andrea, and Narciso, Pasquale
Published: 2005
Full Text: View/download PDF

28. Scoring the 10‐year risk of ambulatory disability in multiple sclerosis: the RoAD score

Author: Gasperini, Claudio, primary, Prosperini, Luca, additional, Rovira, Àlex, additional, Tintoré, Mar, additional, Sastre‐Garriga, Jaume, additional, Tortorella, Carla, additional, Haggiag, Shalom, additional, Galgani, Simonetta, additional, Capra, Ruggero, additional, Pozzilli, Carlo, additional, Montalban, Xavier, additional, and Río, Jordi, additional
Published: 2021
Full Text: View/download PDF

29. Benefits of eculizumab in AQP4+ neuromyelitis optica spectrum disorder: Subgroup analyses of the randomized controlled phase 3 PREVENT trial

Author: Palace, Jacqueline, primary, Wingerchuk, Dean M., additional, Fujihara, Kazuo, additional, Berthele, Achim, additional, Oreja-Guevara, Celia, additional, Kim, Ho Jin, additional, Nakashima, Ichiro, additional, Levy, Michael, additional, Terzi, Murat, additional, Totolyan, Natalia, additional, Viswanathan, Shanthi, additional, Wang, Kai-Chen, additional, Pace, Amy, additional, Yountz, Marcus, additional, Miller, Larisa, additional, Armstrong, Róisín, additional, Pittock, Sean, additional, Muñoz, Daniel Julio, additional, Amor, Jorge David, additional, Bocchiardo, Carolina, additional, Danielle, Julieta Iourno, additional, Laffue, Alfredo, additional, Obregon, Carolina Daniela Diaz, additional, Paez, Maria Fernanda, additional, Perez, Roberto Martin, additional, Rocchi, Viviana Ana Maria, additional, Teijeiro, Loreley Deborah, additional, Gómez, Jesica, additional, Villa, Andres Maria, additional, Aguirre, Florencia, additional, Fernández, Victoria Carla, additional, Goicoechea, Ramon F., additional, Melamud, Luciana, additional, Stillman, Ana, additional, de Virgiliis, Mariana, additional, Cassara, Fatima Pagani, additional, Cordoba, Marta, additional, Gutierrez, Maria Teresa, additional, Ingolotti, Mariana, additional, Larripa, Natalia, additional, Lupinacci, Anahi, additional, Arroyo, Josefina, additional, Romano, Alejandra, additional, Torres, Mariana Foa, additional, Ballario, Carlos Héctor, additional, Chiesa, Ana Elisa, additional, Gómez, Hernán Gustavo, additional, Lattini, Hernán Gabriel, additional, Mainella, Carolina Natalia, additional, Bolner, Gisel Edith, additional, Eschoyez, María Soledad, additional, Broadley, Simon Andrew, additional, Heshmat, Saman, additional, Sabet, Arman, additional, Swayne, Andrew, additional, Freeman, Susan, additional, Sanchez, Sofia Jimenez, additional, Shuey, Neil, additional, Dalic, Linda, additional, French, Ann, additional, Kuma, Guru, additional, Laing, Joshua, additional, Law, Lai Yin, additional, MacIntyre, Jennifer, additional, Neal, Andrew, additional, Plummer, Christopher, additional, Ramachandran, Prashanth, additional, Sedal, Leslie, additional, Wilson, Ian, additional, Winkel, Antony, additional, Zhang, Wenwen, additional, Chen, Tina, additional, Watts, Rani, additional, Barnett, Michael, additional, Barton, Joshua, additional, Beadnall, Heidi, additional, Garber, Justin, additional, Hardy, Todd Andrew, additional, Trewin, Benjamin, additional, Taha, Marinda, additional, Walters, Deleni, additional, Sieger, Federico Arturo Silva, additional, Alfonso, Nhora Patricia Ruiz, additional, Camacho, Anna Maria Pinzon, additional, Moreno, Alexander Pabón, additional, Prad, Jorge Armando Castellanos, additional, Rueda, Adriana Paola Duarte, additional, Castillo, Tatiana, additional, Gonzalez, Karol Melissa Castillo, additional, Pico, Martha Yolanda Moreno, additional, Castill, Judith, additional, Habek, Mario, additional, Adamec, Ivan, additional, Barun, Barbara, additional, Crnosija, Luka, additional, Gabelic, Tereza, additional, Nytrova, Petra, additional, Krasulova, Eva, additional, Pavlickova, Jana, additional, Tyblova, Michaela, additional, Zubkova, Jana, additional, Petersen, Thor, additional, Dale, Gro Helen, additional, Rasmussen, Peter Vestergaard, additional, Stilund, Morten, additional, Svendsen, Kristina Bacher, additional, Brandt, Vivi, additional, Collongues, Nicolas, additional, Fleury, Marie-Celine, additional, Kremer, Laurent, additional, Bendele, Sandrine, additional, Neff, Valérie, additional, Diem, Ricarda, additional, Platten, Michael, additional, Berberich, Anne, additional, Jansen, Jonabelle, additional, Jaschoneck, Hannah, additional, Wildemann, Brigitte, additional, Aures, Ursula, additional, Brandenburger, Tanja, additional, Haut, Tanja, additional, Fernández, Maria-Lourdes Treceno, additional, Aly, Lilian, additional, Brinkhoff, Kirsten, additional, Buck, Dorothea, additional, Golkowski, Daniel, additional, Hermisson, Mirjam, additional, Hoshi, Muna-Miriam, additional, Kaminski, Miriam, additional, Kowarik, Markus Christian, additional, Kronsbein, Helena, additional, Lehmann-Horn, Klaus, additional, Pongratz, Viola Maria, additional, Schweiker, Andreas, additional, Leddy, Lisa-Ann, additional, Mueller, Silvia, additional, Obergfell, Kim, additional, Wanka, Marion, additional, Zettl, Uwe Klaus, additional, Klinke, Jan, additional, Loebermann, Micha, additional, Meister, Stefanie, additional, Rimmele, Florian, additional, Winkelmann, Alexander, additional, Schroeder, Ina, additional, Lau, Alexander Yuk-Lun, additional, Au, Lisa Wing-Chi, additional, Fan, Florence Sin-Ying, additional, Ip, Vincent Hing-Lung, additional, Ma, Karen Ka-Yan, additional, Ma, Sze-Ho, additional, Mok, Vincent Chung-Tong, additional, Au, Cheryl Chung-Kwan, additional, Kwan, Pauline Wing-Lam, additional, Patti, Francesco, additional, Caramma, Andrea Salvatore, additional, Chisari, Clara Grazia, additional, Fermo, Salvatore Lo, additional, Messina, Silvia, additional, Projetto, Maria, additional, Caserta, Cinzia, additional, Filla, Alessandro, additional, Costabile, Teresa, additional, Pane, Chiara, additional, Sacca, Francesco, additional, Marsili, Angela, additional, Puorro, Giorgia, additional, Bergamaschi, Roberto, additional, Berra, Eliana, additional, Mallucci, Giulia, additional, Fattore, Cinzia, additional, Gasperini, Claudio, additional, Galgani, Simonetta, additional, Haggiag, Shalom, additional, Ruggieri, Serena, additional, Vento, Claudio, additional, Quartuccio, Esmeralda Maria, additional, Pozzilli, Carlo, additional, Barletta, Valeria Teresa, additional, Borriello, Giovanna, additional, De Giglio, Laura, additional, Marinelli, Fabiana, additional, Tasillo, Miriam, additional, Amadori, Alessandra, additional, Fischetti, Mariano, additional, Gurreri, Flavia, additional, Mori, Masahiro, additional, Masuda, Hiroki, additional, Ohtani, Ryohei, additional, Sekiguchi, Yukari, additional, Uchida, Tomohiko, additional, Uzawa, Akiyuki, additional, Ito, Hiromi, additional, Kabasawa, Emi, additional, Kaneko, Yoko, additional, Matsushita, Takuya, additional, Matsuse, Dai, additional, Murai, Hiroyuki, additional, Hayashi, Shintaro, additional, Masak, Katsuhisa, additional, Ogata, Hidenori, additional, Shinoda, Koji, additional, Uehara, Taira, additional, Watanabe, Mitsuru, additional, Yamaguchi, Hiroo, additional, Yamasaki, Ryo, additional, Yonekawa, Tomomi, additional, Jingu, Maki, additional, Nagano, Makiko, additional, Nakamura, Yumiko, additional, Sano, Yoshiko, additional, Araki, Manabu, additional, Lin, Youwei, additional, Mori, Madoka, additional, Mukai, Yohei, additional, Sano, Terunori, additional, Sato, Wakiro, additional, Gogun, Naoya, additional, Maeda, Yuriko, additional, Nishimoto, Asami, additional, Tsukamoto, Sachiko, additional, Yanagi, Ritsuko, additional, Saida, Takahiko, additional, Nakamura, Shinichi, additional, Nasu, Tetsuya, additional, Saida, Kyoko, additional, Shikata, Yuko, additional, Kodani, Yoshimi, additional, Saeki, Megumi, additional, Sawada, Yukako, additional, Yoshikawa, Hiroo, additional, Kimura, Takashi, additional, Nishi, Masamitsu, additional, Sakamoto, Shun, additional, Ukon, Shinichiro, additional, Watanabe, Shohei, additional, Ebisuya, Saori, additional, Kimura, Nami, additional, Matsuura, Manami, additional, Morisaki, Yukie, additional, Muroi, Yoshiko, additional, Onishi, Kuniko, additional, Oshima, Ikuko, additional, Washino, Yuki, additional, Yamashita, Tomomi, additional, Misu, Tatsuro, additional, Kaneko, Kimihiko, additional, Kato, Masaaki, additional, Kuroda, Hiroshi, additional, Kurosawa, Kazuhiro, additional, Nishiyama, Shuhei, additional, Ono, Hirohiko, additional, Takai, Yoshiki, additional, Abe, Keiko, additional, Hoshi, Hitomi, additional, Jinushi, Mari, additional, Oyama, Azusa, additional, Sakuma, Motonari, additional, Sawada, Yuko, additional, Ishibashi, Satoru, additional, Yokota, Takanori, additional, Nishida, Yoichiro, additional, Ozaki, Kokoro, additional, Sanjo, Nobuo, additional, Sato, Nozomu, additional, Denno, Fuki, additional, Hiraki, Haruko, additional, Matsubara, Yumi, additional, Kanda, Takashi, additional, Abe, Masaaki, additional, Honda, Masaya, additional, Kawai, Motoharu, additional, Koga, Michiaki, additional, Maeda, Toshihiko, additional, Ogasawara, Junichi, additional, Omoto, Masatoshi, additional, Sano, Yasuteru, additional, Sato, Ryota, additional, Shimizu, Fumitaka, additional, Arima, Hideki, additional, Fukui, Sachie, additional, Ishikawa, Yoshiko, additional, Koyama, Tomoko, additional, Shimose, Shigemi, additional, Shinozaki, Hirokazu, additional, Watanabe, Masanori, additional, Yasuda, Sachi, additional, Yoshiwaka, Chieko, additional, Adenan, Suffian, additional, Aris, Mohd Azman M, additional, Mawardi, Ahmad Shahir bin, additional, Adnan, Muhammad Al Hafiz, additional, Munusamy, Nanthini, additional, Razali, Siti Nur Omaira, additional, Somasundram, Punitha, additional, Hyun, Jae Won, additional, Jeong, In Hye, additional, Kim, Su-Hyun, additional, Shin, Hyun-June, additional, Yoo, Ji Sung, additional, Jang, HyunMin, additional, Joung, AeRan, additional, Kim, Byung-Jo, additional, Baek, Seol-Hee, additional, Kim, Jung Bin, additional, Kim, Yoo Hwan, additional, Koo, Yong Seo, additional, Lee, Chan Nyoung, additional, Seok, Hung Youl, additional, Hwang, Jinhee, additional, Kim, Sung Min, additional, Ahn, So Hyun, additional, Choi, Kyomin, additional, Choi, Seok-Jin, additional, Kim, Jun-Soon, additional, Kwon, Young Nam, additional, Shin, Je-Young, additional, Kwon, Hyeonju, additional, Kim, Byoung Joon, additional, Cho, Eun Bin, additional, Cho, Hye-Jin, additional, Choi, Misong, additional, Kim, DongSun, additional, Kim, Ju Hyeon, additional, Ki, SeungJu, additional, Lee, Hye Lim, additional, Lee, Kwang-Ho, additional, Min, Ju-Hong, additional, Park, Ji-Hyung, additional, Seok, Jinmyoung, additional, Choi, Eunhwa, additional, Park, Sang Ae, additional, Kim, Seung Min, additional, Jeong, Ha-Neul, additional, Jeongbin, Bong, additional, Jung, Jin Woo, additional, Kim, Seung Woo, additional, Kim, Yool-hee, additional, Lee, Hyung Seok, additional, Shin, Ha Young, additional, Jung, Yeon, additional, Kim, Min Jung, additional, Lee, Nou Ri, additional, Shin, MiJu, additional, Khabirov, Farit A, additional, Averyanova, Lyudmila, additional, Babicheva, Natalya, additional, Granatov, Eugenii, additional, Kazarov, Sergey, additional, Khaybullin, Timur, additional, Rogozhin, Alexander, additional, Pokhabov, Dmitry V, additional, Abramov, Vladislav, additional, Amelina, Anastasia, additional, Nesteroca, Yulia, additional, Bozhenkina, Tatyana, additional, Boyko, Aleksey N, additional, Demyan, Elena G, additional, Khoroshilova, Inessa, additional, Melnikov, Mikhail, additional, Popova, Ekaterina V, additional, Sharanova, Svetlana N, additional, Shchur, Sergey G, additional, Sazonov, Denis V, additional, Babenko, Larisa, additional, Bayandina, Elena, additional, Yarmoschuk, Asya, additional, Baliazin, Victor A, additional, Baliazina, Elena, additional, Budaeva, Elena, additional, Chernikova, Irina, additional, Goncharova, Zoya, additional, Krasnov, Vladimir, additional, Myatleva, Marina, additional, Rodionova, Olga V., additional, Samulyzhko, Iuliana, additional, Timofeeva, Alla A., additional, Duran, Sabas Boyero, additional, Bilbao, Maria Mar Mendibe, additional, Cuervo, Irene Diaz, additional, Domingo, Jose Maria Losada, additional, Eizaguirre, Amaia Gonzalez, additional, Llona, Jose Eulalio Barcena, additional, Moyano, Roberto Valverde, additional, Bahamonde, Carmen, additional, Lopez, Fernando Sanchez, additional, Morales, Raquel Pinar, additional, Morales, Eduardo Agüera, additional, Roman, Carmen Bahamonde, additional, Sepulveda, Juan Jose Ochoa, additional, Valero, Maria del Carmen Blanco, additional, Viña, Nazaret Pelaez, additional, Gavilan, Cristina Conde, additional, Sanchez, Ana Maria Jover, additional, Bedmar, Sara Vila, additional, Garcia, Nuria Gonzalez, additional, Garcia, Aida Orviz, additional, Gonzalez-Suarez, Ines, additional, Guillamon, Elena Miñano, additional, Kawiorski, Miguel, additional, Schulz, Elena Guerra, additional, Alonso, Alba Garcia, additional, Perez, Francisco Jesus Lopez, additional, Sarmiento, Marta Palacios, additional, Ayuso, Guillermo Izquierdo, additional, Mascarell, Guillermo Navarro, additional, Camino, Cristina Paramo, additional, Garcia, Asuncion Varas, additional, Mendoza, Yaiza Montserrat, additional, Muñoz, Veronica Ines Vargas, additional, Tonda, Patricia Torres, additional, Tsai, Ching-Piao, additional, Yin, Jiu-Haw, additional, Chen, Mei-Jung, additional, Li, Shan-Ni, additional, Wang, Fei-Ti, additional, Srisuwannanukorn, Suwat, additional, Boonmongkol, Thanatat, additional, Borisutbuathip, Duangporn, additional, Singwicha, Duangkamol, additional, Siritanan, Krittika, additional, Thearapati, Chidchanoke, additional, Sornda, Kwanmuang, additional, Apiwattanakul, Metha, additional, Aungsumart, Saharat, additional, Suanprasert, Narupat, additional, Suksuchano, Kaona, additional, Parkinsee, Nittaya, additional, Kulkantrakorn, Kongkiat, additional, Lolekha, Praween, additional, Potigumjon, Artit, additional, Sukphulloprat, Puchit, additional, Suksasunee, Dararat, additional, Komaratat, Chankawee, additional, Luangtong, Sunattana, additional, Arayawichanont, Arkhom, additional, Konpan, Phanpaphon, additional, Riablershirun, Nathapol, additional, Wiroteurairuang, Thaddao, additional, Jantaweesirirat, Panadda, additional, Kurne, Aslı, additional, Erkent, Irem, additional, Kurt, Ebru Bekircan, additional, Saylam, Ezgi, additional, Caliskan, Yagmur, additional, Orsel, Gulsah, additional, Celik, Yahya, additional, Celebi, Canan, additional, Tekatas, Aslan, additional, Banbal, Tugce, additional, Demir, Gulsen Akman, additional, Altunrende, Burcu, additional, Matur, Zeliha, additional, Topcular, Baris, additional, Elmas, Tules, additional, Gulo, Aysenur, additional, Ozdemir, Selin, additional, Ozkoklesen, Cansu, additional, Ozturk, Mahinur, additional, Yanik, Mertkan, additional, Yildirim, Elif, additional, Tutuncu, Melih, additional, Altintas, Ayse, additional, Cam, Abdulsamet, additional, Elmali, Ayse Deniz, additional, Saip, Sabahattin, additional, Siva, Aksel, additional, Tanrıverdi, Uygur, additional, Uygunoglu, Ugur, additional, Caliskan, Sinem, additional, Gulo, Pinar, additional, Kozig, Esra, additional, Sakiz, Sakine, additional, Sengun, Ihsan Sukru, additional, Idiman, Egemen, additional, Ala, Rahmi Tumay, additional, Arslan, Duygu, additional, Bulut, Utku, additional, Karakaptan, Yasemin, additional, Kaya, Derya, additional, Mehdiyev, Zaur, additional, Balkan, Bengu, additional, Kuku, Berfu, additional, Ozhun, Mujgan, additional, Tuga, Celal, additional, Ugur, Muzeyyen, additional, Efendi, Husnu, additional, Bunul, Sena Destan, additional, Cavus, Hakan, additional, Gorke, Yunus Emre, additional, Kutlu, Ayse, additional, Ozturk, Seda, additional, Sarikaya, Cansu Egilmez, additional, Becerikli, Gulsah, additional, Semiz, Cansu, additional, Tun, Ozlem, additional, Ayer, Sehriban, additional, Onar, Musa Kazim, additional, Ozberk, Mehlika Berra, additional, Sen, Sedat, additional, Cavdar, Tugce Kirbas, additional, Veske, Adife, additional, Boz, Cavit, additional, Altiparmak, Didem, additional, Aydin, Cigdem Ozen, additional, Gazioglu, Sibel, additional, Bekircan, Duygu, additional, Jacob, Anu, additional, Arndt, Heike, additional, Elsone, Liene, additional, Hamid, Shahd Hassan Mahmoud, additional, Whittam, Daniel Hugh, additional, Wilson, Martin, additional, O'Brien, Imelda, additional, Leite, Maria Isabel da Silva, additional, Cruz, Pedro Maria Rodriguez, additional, Jenkins, Damian Robert, additional, Tackley, George, additional, Cavey, Ana, additional, Everett, Rosie, additional, Hodder, Joy, additional, Koelewyn, Abigail, additional, Mowry, Ellen, additional, Royal, Walter, additional, Shin, Robert, additional, Bever, Christopher, additional, Harrison, Daniel, additional, Rus, Horea, additional, Zheng, Wei, additional, Callison, Karen, additional, Naunton, Kerry, additional, Frishberg, Benjamin M, additional, Blumenfeld, Andrew M, additional, Inocelda, Andrew, additional, Korabathina, Kalyani, additional, Lobatz, Michael, additional, Mortin, Melissa M, additional, Oh, Irene J, additional, Rosenberg, Jay H, additional, Sadoff, Mark, additional, Sahagian, Gregory A, additional, Wang, Anchi, additional, Camberos, Yasmin, additional, Sanchez, Guadalupe, additional, Soto, Estela, additional, Nicholas, Jacqueline A, additional, Boster, Aaron, additional, Eubank, Geoffrey, additional, Groezinger, Katy, additional, Lauf, Meghan, additional, Okai, Annette F, additional, Hasan, Rashedul, additional, Khoury, Chaouki, additional, Stokes, Victoria, additional, Clardy, Stacey, additional, Cortez, Melissa, additional, Greenlee, John, additional, Rose, John, additional, Soldan, Mateo Paz, additional, Emett, Amanda, additional, Esquibel, Lawanda, additional, Fagatele, Lilly, additional, Wong, Ka-Ho, additional, Stevens, James C, additional, Banas, Thomas M, additional, Bultemeyer, Marlene C, additional, Haller, Andrea, additional, Manalo, Natalie, additional, Aeschliman, Keri, additional, Kocks, Debi, additional, Racke, Michael, additional, Boster, Aaron Lee, additional, Bowman, Michelle, additional, Imitola, Jaime, additional, Kisanuki, Yasushi, additional, Green, Misty, additional, Scarberry, Stephanie, additional, Lynch, Sharon G, additional, Anderson, Heather S, additional, Gronseth, Gary S, additional, Hammond, Nancy E, additional, Jassam, Yasir N, additional, Mittal, Manoj K, additional, Nashatizadeh, Muhammed M, additional, Levine, Nicholas, additional, Schmidt, Lisa, additional, Sibley, Jill, additional, Whitley, Vonda, additional, Winkley, James, additional, Coleman, Timothy, additional, Cooper, Gregory, additional, Sheffield, Stephanie, additional, Turner, Keri, additional, Galloway, Dana, additional, Tillett, Robert S, additional, Ganesh, Geeta A, additional, Plato, Brian M, additional, Seifert, Tad D, additional, Godwin, Diana, additional, Lockridge, Deborah, additional, Rammohan, Kottil W, additional, Sheremata, William A, additional, Delgado, Silvia, additional, Gonzalez, Jose, additional, Lizarraga, Alexis, additional, Maldonado, Janice, additional, Ortega, Melissa, additional, Tornes, Leticia, additional, Babcock, Yanet, additional, Cailam, Osmara, additional, Campos, Yesica, additional, Couvertier, Irlisse, additional, Daneri, Bettina, additional, Deni, Jeremy, additional, Hernandez, Jeffrey, additional, Jaramillo, Tatiana, additional, Morris, Tenita, additional, Nobel, Daniel, additional, Oliveira, Anjelis, additional, Richardson, Reshma, additional, Rodriguez, Gloria, additional, Romero, Ana, additional, Sandova, Carlos, additional, Sawant, Ruta, additional, Tueros, Lissett, additional, Zetka, Eric S, additional, Zheng, Chao, additional, Jacobs, Daniel H, additional, Easterling, Constance, additional, Fairbank, Jennifer, additional, Iyengar, Revathi, additional, Klafter, Mark, additional, Lindquist, Justin, additional, Sadek, Ahmed H, additional, Toro, Elizabeth Carmona, additional, Verma, Navin, additional, Castro, Brigith Patino, additional, Sukhraj-Singh, Nadia, additional, Berger, Joseph, additional, Williamson, Eric, additional, Chahin, Salim, additional, Jacobs, Dina, additional, Markowitz, Clyde, additional, Dobbins, Jessica, additional, Mace, Lauren, additional, Martin, Maria, additional, Pinckney, Ashley, additional, Roberts, Amber, additional, Zaydan, Islam, additional, Mitchell, Galen W, additional, Heyman, Rock A, additional, Orie, Ryan L, additional, Suski, Valerie R, additional, Oddis, Kerry, additional, Punjack, Darlene, additional, Flanagan, Eoin, additional, Gadoth, Avi, additional, McKeon, Andrew, additional, Tobin, W Oliver, additional, Zekeridou, Anastasia, additional, Dunlay, Katie, additional, Sagen, Jessica, additional, Carter, Jonathan L, additional, Estephan, Bachir, additional, Goodman, Brent P, additional, Snyder, Charlene R Hoffman, additional, Francone, Andrea, additional, Galasky, Irene, additional, Thomas, Martha, additional, Repovic, Pavle, additional, Bowen, James, additional, Mayadev, Angeli, additional, Qian, Peiqing, additional, Courtney, Yuriko, additional, Lennox, Lauren, additional, Naismith, Robert Thomas, additional, Cross, Anne Haney, additional, Evans, Emily, additional, Longbrake, Erin E, additional, Orchard, Megan E, additional, Wu, Gregory F, additional, Heinrich, Linda, additional, Sommers, Susan, additional, Amjad, Faria, additional, Mitchell, Erika, additional, Mora, Carlos, additional, Schreiber, Bethany, additional, Tornatore, Carlo, additional, Carlson, Alexis, additional, McCarthy, Sacha, additional, and Oliver, Alexandria, additional
Published: 2021
Full Text: View/download PDF

30. Changes in neurocognitive performance in a cohort of patients treated with HAART for 3 years

Author: Tozzi, Valerio, Balestra, Pietro, Galgani, Simonetta, Narciso, Pasquale, Sampaolesi, Alessandro, Antinori, Andrea, Giulianelli, Marinella, Serraino, Diego, and Ippolito, Giuseppe
Subjects: Epidemiology -- Statistics, Epidemiology -- Research, HIV patients -- Case studies, HIV patients -- Health aspects, HIV patients -- Care and treatment, HIV infection -- Prevention, HIV infection -- Research, HIV infection -- Health aspects, Highly active antiretroviral therapy -- Methods, Protease inhibitors -- Physiological aspects, AIDS dementia -- Care and treatment, AIDS dementia -- Health aspects, AIDS dementia -- Causes of, AIDS (Disease) -- Research, Health
Abstract: Research has been conducted on HIV-associated neurocognitive inpairment in patients treated with highly active antiretroviral therapy. The authors have investigated the changes in these patients after the treatment, and they have concluded that the ongoing HIV-related neurologic damage can occur even during the antiretroviral treatment.
Published: 2001

31. Age-related adverse events of disease-modifying treatments for multiple sclerosis: A meta-regression

Author: Prosperini, Luca, primary, Haggiag, Shalom, additional, Tortorella, Carla, additional, Galgani, Simonetta, additional, and Gasperini, Claudio, additional
Published: 2020
Full Text: View/download PDF

32. Disease-modifying drugs can reduce disability progression in relapsing multiple sclerosis

Author: Amato, Maria Pia, primary, Fonderico, Mattia, additional, Portaccio, Emilio, additional, Pastò, Luisa, additional, Razzolini, Lorenzo, additional, Prestipino, Elio, additional, Bellinvia, Angelo, additional, Tudisco, Laura, additional, Fratangelo, Roberto, additional, Comi, Giancarlo, additional, Patti, Francesco, additional, De Luca, Giovanna, additional, Brescia Morra, Vincenzo, additional, Cocco, Eleonora, additional, Pozzilli, Carlo, additional, Sola, Patrizia, additional, Bergamaschi, Roberto, additional, Salemi, Giuseppe, additional, Inglese, Matilde, additional, Millefiorini, Enrico, additional, Galgani, Simonetta, additional, Zaffaroni, Mauro, additional, Ghezzi, Angelo, additional, Salvetti, Marco, additional, Lus, Giacomo, additional, Florio, Ciro, additional, Totaro, Rocco, additional, Granella, Franco, additional, Vianello, Marika, additional, Gatto, Maurizia, additional, Di Battista, Giancarlo, additional, Aguglia, Umberto, additional, Logullo, Francesco Ottavio, additional, Simone, Marta, additional, Lucisano, Giuseppe, additional, Iaffaldano, Pietro, additional, and Trojano, Maria, additional
Published: 2020
Full Text: View/download PDF

33. Additional file 4 of Simultaneous quantification of natural and inducible regulatory T-cell subsets during interferon-β therapy of multiple sclerosis patients

Author: Chiarini, Marco, Capra, Ruggero, Serana, Federico, Bertoli, Diego, Sottini, Alessandra, Giustini, Viviana, Scarpazza, Cristina, Rovaris, Marco, Clerici, Valentina Torri, Ferraro, Diana, Galgani, Simonetta, Solaro, Claudio, Conti, Marta Zaffira, Visconti, Andrea, and Imberti, Luisa
Abstract: Additional file 4: Figure S2. The absolute number of total lymphocytes (A), naïve Treg (B), TregCM (C), TregEM (D), CD120b+ nTreg (E), and Tr1 (F) after IFN-β treatment was investigated at T0: before therapy initiation and T6, T12, T18, and T24: after 6, 12, 18, and 24 months of IFN-β, respectively. Estimated means are shown, connected by continuous lines, along with error bars representing the 95% confidence interval. Black lines indicate statistically significant decreases, while red lines indicate statistically significant increases.
Published: 2020
Full Text: View/download PDF

34. Additional file 5 of Simultaneous quantification of natural and inducible regulatory T-cell subsets during interferon-β therapy of multiple sclerosis patients

Author: Chiarini, Marco, Capra, Ruggero, Serana, Federico, Bertoli, Diego, Sottini, Alessandra, Giustini, Viviana, Scarpazza, Cristina, Rovaris, Marco, Clerici, Valentina Torri, Ferraro, Diana, Galgani, Simonetta, Solaro, Claudio, Conti, Marta Zaffira, Visconti, Andrea, and Imberti, Luisa
Abstract: Additional file 5: Figure S3. Correlation between Cyt-1 and Cyt-2 mRNA expression after stimulation. Scatterplot representing the correlations between Cyt-1 and Cyt-2 values at the indicated time points and conditions. Black lines were obtained by linear regression.
Published: 2020
Full Text: View/download PDF

35. Additional file 3 of Simultaneous quantification of natural and inducible regulatory T-cell subsets during interferon-β therapy of multiple sclerosis patients

Author: Chiarini, Marco, Capra, Ruggero, Serana, Federico, Bertoli, Diego, Sottini, Alessandra, Giustini, Viviana, Scarpazza, Cristina, Rovaris, Marco, Clerici, Valentina Torri, Ferraro, Diana, Galgani, Simonetta, Solaro, Claudio, Conti, Marta Zaffira, Visconti, Andrea, and Imberti, Luisa
Subjects: hemic and immune systems
Abstract: Additional file 3: Figure S1. The gating strategy ensures the quality and continuity of data acquired for the whole blood and allows the identification of: (A) single-cell lymphocytes, which can be distinguished by their forward scatter/side scatter properties;(B) after lymphocyte gating, doublets are excluded, followed by exclusion of dead or autofluorescent cells; (C) naive, central memory (CM), and effector memory (EM) CD4+ cells based on the expression of C45RA and CCR7 markers; (D) CD4+ Tr1 cells based on the expression of CD18 and high level of CD49b expression; (E) CD4+ Treg cells based on positive expression of CD25 and low/negative expression of CD127; and (F) Treg subsets population (naïve Treg, TregCM, and TregEM) based on the expression of C45RA and CCR7 markers. (G and H) CD120b (TNFR2) expressing cells (black line) within nTreg population (dark grey) compared to naïve CD4+ lymphocytes (grey) and monocytes (light grey), which are respectively negative and positive for the expression of CD120b antigen.
Published: 2020
Full Text: View/download PDF

36. MSJ964778_Appendix – Supplemental material for Age-related adverse events of disease-modifying treatments for multiple sclerosis: A meta-regression

Author: Prosperini, Luca, Haggiag, Shalom, Tortorella, Carla, Galgani, Simonetta, and Gasperini, Claudio
Subjects: FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract: Supplemental material, MSJ964778_Appendix for Age-related adverse events of disease-modifying treatments for multiple sclerosis: A meta-regression by Luca Prosperini, Shalom Haggiag, Carla Tortorella, Simonetta Galgani and Claudio Gasperini in Multiple Sclerosis Journal
Published: 2020
Full Text: View/download PDF

37. Additional file 6 of Simultaneous quantification of natural and inducible regulatory T-cell subsets during interferon-β therapy of multiple sclerosis patients

Author: Chiarini, Marco, Capra, Ruggero, Serana, Federico, Bertoli, Diego, Sottini, Alessandra, Giustini, Viviana, Scarpazza, Cristina, Rovaris, Marco, Clerici, Valentina Torri, Ferraro, Diana, Galgani, Simonetta, Solaro, Claudio, Conti, Marta Zaffira, Visconti, Andrea, and Imberti, Luisa
Abstract: Additional file 6: Figure S4. Subdivision of patients according to the variations of each Treg subset at T24. Patients were grouped based on the increase (↑), maintenance or slight increase (=/↑), or decrease (↓) of the different Treg subset percentages after 24 months of IFN-β therapy. Therefore, only 86 patients that completed the follow-up were included in the analysis. TregCM ↑: ≥ 6%, =/↑: -1 to
Published: 2020
Full Text: View/download PDF

38. Age-related adverse events of disease-modifying treatments for multiple sclerosis: A meta-regression.

Author: Prosperini, Luca, Haggiag, Shalom, Tortorella, Carla, Galgani, Simonetta, and Gasperini, Claudio
Subjects: MULTIPLE sclerosis, OPPORTUNISTIC infections, CLINICAL trials, TUMORS
Abstract: Objective: To verify the hypothesis of an age-dependent increase of infections and neoplasms in patients with multiple sclerosis (MS) under disease-modifying treatments (DMTs) with different mechanisms of action. Methods: We extracted relevant data from 45 randomized clinical trials (RCTs) on currently licensed DMTs. We fitted inverse-variance weighted meta-regressions with random-effects models to estimate whether age and/or mechanism of action (immunomodulatory, sequestrating, and depletive) of currently licensed DMTs influenced the difference between experimental arm and control arm in the incidence of specific adverse events, namely, overall infections, opportunistic infections, and neoplasms. Results: A higher incidence of overall infections was observed in RCTs with depletive DMTs (event-rate ratio = 1.25, p < 0.001). Herpetic infections were more frequently observed in RCTs with both depletive (event-rate ratio = 3.51, p < 0.001) and, to a lesser extent, sequestrating DMTs (event-rate ratio = 1.52, p = 0.078). The interaction of age with depletive DMTs was associated with higher incidence of neoplasms (p = 0.017), especially above 45 years of age. Discussion: Our study supports a detrimental effect of age on the safety profile of depletive DMTs, with an increased incidence of neoplasms especially over 45 years of age. We failed to demonstrate an age-related increased incidence of infections, possibly due to latency in their occurrence. [ABSTRACT FROM AUTHOR]
Published: 2021
Full Text: View/download PDF

39. Positive and sustained effects of highly active antiretroviral therapy on HIV-1-associated neurocognitive impairment

Author: Tozzi, Valerio, Balestra, Pietro, Galgani, Simonetta, Narciso, Pasquale, Ferri, Fabrizio, Sebastiani, Gabriella, D‚Amato, Carmelo, Affricano, Cesare, Pigorini, Francesco, Pau, Franca Maria, De Felici, Annapaola, and Benedetto, Arrigo
Published: 1999

40. Minimal evidence of disease activity (MEDA) in relapsing-remitting multiple sclerosis

Author: Prosperini, Luca, primary, Mancinelli, Chiara, additional, Haggiag, Shalom, additional, Cordioli, Cinzia, additional, De Giglio, Laura, additional, De Rossi, Nicola, additional, Galgani, Simonetta, additional, Rasia, Sarah, additional, Ruggieri, Serena, additional, Tortorella, Carla, additional, Pozzilli, Carlo, additional, and Gasperini, Claudio, additional
Published: 2020
Full Text: View/download PDF

41. Exit strategies for “needle fatigue” in multiple sclerosis: a propensity score-matched comparison study

Author: Prosperini, Luca, primary, Cortese, Antonio, additional, Lucchini, Matteo, additional, Boffa, Laura, additional, Borriello, Giovanna, additional, Buscarinu, Maria Chiara, additional, Capone, Fioravante, additional, Centonze, Diego, additional, De Fino, Chiara, additional, De Pascalis, Daniela, additional, Fantozzi, Roberta, additional, Ferraro, Elisabetta, additional, Filippi, Maria, additional, Galgani, Simonetta, additional, Gasperini, Claudio, additional, Haggiag, Shalom, additional, Landi, Doriana, additional, Marfia, Girolama, additional, Mataluni, Giorgia, additional, Millefiorini, Enrico, additional, Mirabella, Massimiliano, additional, Monteleone, Fabrizia, additional, Nociti, Viviana, additional, Pontecorvo, Simona, additional, Romano, Silvia, additional, Ruggieri, Serena, additional, Salvetti, Marco, additional, Tortorella, Carla, additional, Zannino, Silvana, additional, and Di Battista, Giancarlo, additional
Published: 2019
Full Text: View/download PDF

42. The influence of physiotherapy intervention on patients with multiple sclerosis–related spasticity treated with nabiximols (THC:CBD oromucosal spray)

Author: Grimaldi, Alessandro Enrico, primary, De Giglio, Laura, additional, Haggiag, Shalom, additional, Bianco, Assunta, additional, Cortese, Antonio, additional, Crisafulli, Sebastiano Giuseppe, additional, Monteleone, Fabrizia, additional, Marfia, Gerola, additional, Prosperini, Luca, additional, Galgani, Simonetta, additional, Mirabella, Massimiliano, additional, Centonze, Diego, additional, Pozzilli, Carlo, additional, and Castelli, Letizia, additional
Published: 2019
Full Text: View/download PDF

43. Transition to secondary progression in relapsing-onset multiple sclerosis: Definitions and risk factors.

Author: Iaffaldano, Pietro, Lucisano, Giuseppe, Patti, Francesco, Brescia Morra, Vincenzo, De Luca, Giovanna, Lugaresi, Alessandra, Zaffaroni, Mauro, Inglese, Matilde, Salemi, Giuseppe, Cocco, Eleonora, Conte, Antonella, Ferraro, Diana, Galgani, Simonetta, Bergamaschi, Roberto, Pozzilli, Carlo, Salvetti, Marco, Lus, Giacomo, Rovaris, Marco, Maniscalco, Giorgia Teresa, and Logullo, Francesco Ottavio
Subjects: MULTIPLE sclerosis, DISABILITIES, AGE of onset, DEFINITIONS, DISEASE relapse, MEDICAL registry personnel
Abstract: Background: No uniform criteria for a sensitive identification of the transition from relapsing–remitting multiple sclerosis (MS) to secondary-progressive multiple sclerosis (SPMS) are available. Objective: To compare risk factors of SPMS using two definitions: one based on the neurologist judgment (ND) and an objective data-driven algorithm (DDA). Methods: Relapsing-onset MS patients (n = 19,318) were extracted from the Italian MS Registry. Risk factors for SPMS and for reaching irreversible Expanded Disability Status Scale (EDSS) 6.0, after SP transition, were estimated using multivariable Cox regression models. Results: SPMS identified by the DDA (n = 2343, 12.1%) were older, more disabled and with a faster progression to severe disability (p < 0.0001), than those identified by the ND (n = 3868, 20.0%). In both groups, the most consistent risk factors (p < 0.05) for SPMS were a multifocal onset, an age at onset >40 years, higher baseline EDSS score and a higher number of relapses; the most consistent protective factor was the disease-modifying therapy (DMT) exposure. DMT exposure during SP did not impact the risk of reaching irreversible EDSS 6.0. Conclusion: A DDA definition of SPMS identifies more aggressive progressive patients. DMT exposure reduces the risk of SPMS conversion, but it does not prevent the disability accumulation after the SP transition. [ABSTRACT FROM AUTHOR]
Published: 2021
Full Text: View/download PDF

44. Effects of zidovudine in 30 patients with mild to end-stage AIDS dementia complex

Author: Tozzi, Valerio, Narciso, Pasquale, Galgani, Simonetta, Sette, Pietro, Balestra, Pietro, Gerace, Carmela, Pau, Franca Maria, Pigorini, Francesco, Volpini, Valerio, Camporiondo, Maria Pia, Giulianelli, Marinella, and Visco, Giuseppe
Published: 1993

45. Fingolimod vs dimethyl fumarate in multiple sclerosis

Author: Prosperini, Luca, Lucchini, Matteo, Haggiag, Shalom, Bellantonio, Paolo, Bianco, Assunta, Buscarinu, Maria Chiara, Buttari, Fabio, Centonze, Diego, Cortese, Antonio, De Giglio, Laura, Fantozzi, Roberta, Ferraro, Elisabetta, Fornasiero, Arianna, Francia, Ada, Galgani, Simonetta, Gasperini, Claudio, Marfia, Girolama Alessandra, Millefiorini, Enrico, Nociti, Viviana, Pontecorvo, Simona, Pozzilli, Carlo, Ruggieri, Serena, Salvetti, Marco, Sgarlata, Eleonora, and Mirabella, Massimiliano
Subjects: Multiple sclerosis, case control), Settore MED/26 - NEUROLOGIA, Multiple sclerosis, class IV, clinical trials observational studies (Cohort, case control), class IV, clinical trials observational studies (Cohort
Published: 2018

46. Simultaneous quantification of natural and inducible regulatory T-cell subsets during interferon-β therapy of multiple sclerosis patients.

Author: Chiarini, Marco, Capra, Ruggero, Serana, Federico, Bertoli, Diego, Sottini, Alessandra, Giustini, Viviana, Scarpazza, Cristina, Rovaris, Marco, Torri Clerici, Valentina, Ferraro, Diana, Galgani, Simonetta, Solaro, Claudio, Conti, Marta Zaffira, Visconti, Andrea, Imberti, Luisa, and SURROGATE Study Group
Subjects: SUPPRESSOR cells, T cells, MULTIPLE sclerosis, NATALIZUMAB, TREATMENT effectiveness
Abstract: Background: The mechanisms underlying the therapeutic activity of interferon-β in multiple sclerosis are still not completely understood. In the present study, we evaluated the short and long-term effects of interferon-β treatment on different subsets of regulatory T cells in relapsing-remitting multiple sclerosis patients biologically responsive to treatment because of mixovirus resistance protein A inducibility.Methods: In this prospective longitudinal study, subsets of natural regulatory T cells (naïve, central memory and effector memory) and inducible regulatory T cells (Tr1), as well as in vitro-induced regulatory T cells (Tr1-like cells), were simultaneously quantified by flow cytometry in samples prepared from 148 therapy-naïve multiple sclerosis patients obtained before and after 6, 12, 18, and 24 months of interferon-β-1a treatment. mRNA for interleukin-10 and Tr1-related genes (CD18, CD49b, and CD46, together with Cyt-1 and Cyt-2 CD46-associated isoforms) were quantified in Tr1-like cells.Results: Despite profound inter-individual variations in the modulation of all regulatory T-cell subsets, the percentage of natural regulatory T cells increased after 6, 12, and 24 months of interferon-β treatment. This increase was characterized by the expansion of central and effector memory regulatory T-cell subsets. The percentage of Tr1 significantly enhanced at 12 months of therapy and continued to be high at the subsequent evaluation points. Patients experiencing relapses displayed a higher percentage of naïve regulatory T cells and a lower percentage of central memory regulatory T cells and of Tr1 before starting interferon-β therapy. In addition, an increase over time of central memory and of Tr1 was observed only in patients with stable disease. However, in vitro-induced Tr1-like cells, prepared from patients treated for 24 months, produced less amount of interleukin-10 mRNA compared with pre-treatment Tr1-like cells.Conclusion: Interferon-β induces the expansion of T regulatory subsets endowed with a high suppressive activity, especially in clinically stable patients. The overall concurrent modulation of natural and inducible regulatory T-cell subsets might explain the therapeutic effects of interferon-β in multiple sclerosis patients. [ABSTRACT FROM AUTHOR]
Published: 2020
Full Text: View/download PDF

47. Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study

Author: Kappos, Ludwig, primary, Bar-Or, Amit, additional, Cree, Bruce A C, additional, Fox, Robert J, additional, Giovannoni, Gavin, additional, Gold, Ralf, additional, Vermersch, Patrick, additional, Arnold, Douglas L, additional, Arnould, Sophie, additional, Scherz, Tatiana, additional, Wolf, Christian, additional, Wallström, Erik, additional, Dahlke, Frank, additional, Achiron, Anat, additional, Achtnichts, Lutz, additional, Agan, Kadriye, additional, Akman-Demir, Gulsen, additional, Allen, Alison B, additional, Antel, Jack P, additional, Antiguedad, Alfredo Rodriguez, additional, Apperson, Michelle, additional, Applebee, Angela M, additional, Ayuso, Guillermo Izquierdo, additional, Baba, Masayuki, additional, Bajenaru, Ovidiu, additional, Balasa, Rodica, additional, Balci, Belgin Petek, additional, Barnett, Michael, additional, Bass, Ann, additional, Becker, Veit U, additional, Bejinariu, Mihaela, additional, Bergh, Florian Then, additional, Bergmann, Arnfin, additional, Bernitsas, Evanthia, additional, Berthele, Achim, additional, Bhan, Virender, additional, Bischof, Felix, additional, Bjork, Randall John, additional, Blevins, Gregg, additional, Boehringer, Matthias, additional, Boerner, Thomas, additional, Bonek, Robert, additional, Bowen, James D, additional, Bowling, Allen, additional, Boyko, Alexey N, additional, Boz, Cavit, additional, Bracknies, Vera, additional, Braune, Stefan, additional, Brescia Morra, Vincenzo, additional, Brochet, Bruno, additional, Brola, Waldemar, additional, Brownstone, Paul Kenneth, additional, Brozman, Miroslav, additional, Brunet, Donald, additional, Buraga, Ioan, additional, Burnett, Margaret, additional, Buttmann, Mathias, additional, Butzkueven, Helmut, additional, Cahill, Jonathan, additional, Calkwood, Jonathan C, additional, Camu, William, additional, Cascione, Mark, additional, Castelnovo, Giovani, additional, Centonze, Diego, additional, Cerqueira, Joao, additional, Chan, Andrew, additional, Cimprichova, Andrea, additional, Cohan, Stanley, additional, Comi, Giancarlo, additional, Conway, Jill, additional, Cooper, Joanna A, additional, Corboy, John, additional, Correale, Jorge, additional, Costell, Brian, additional, Cottrell, David A, additional, Coyle, Patricia K, additional, Craner, Matthew, additional, Cui, Liying, additional, Cunha, Luis, additional, Czlonkowska, Anna, additional, da Silva, Ana Martins, additional, de Sa, Joao, additional, de Seze, Jérôme, additional, Debouverie, Marc, additional, Debruyne, Jan, additional, Decoo, Danny, additional, Defer, Gilles, additional, Derfuss, Tobias, additional, Deri, Norma H, additional, Dihenia, Bhupesh, additional, Dioszeghy, Peter, additional, Donath, Vladimir, additional, Dubois, Benedicte, additional, Duddy, Martin, additional, Duquette, Pierre, additional, Edan, Gilles, additional, Efendi, Husnu, additional, Elias, Stanton, additional, Emrich, Peter J, additional, Estruch, Bonaventura Casanova, additional, Evdoshenko, Evgeniy P, additional, Faiss, Juergen, additional, Fedyanin, Alexander S, additional, Feneberg, Wolfgang, additional, Fermont, Jiske, additional, Fernandez, Oscar Fernandez, additional, Ferrer, Francisco Coret, additional, Fink, Katharina, additional, Ford, Helen, additional, Ford, Corey, additional, Francia, Ada, additional, Freedman, Mark, additional, Frishberg, Benjamin, additional, Galgani, Simonetta, additional, Garmany, George P, additional, Gehring, Klaus, additional, Gitt, Jeffrey, additional, Gobbi, Claudio, additional, Goldstick, Lawrence P, additional, Gonzalez, Rafael Arroyo, additional, Grandmaison, Francois, additional, Grigoriadis, Nikolaos, additional, Grigorova, Olga, additional, Grimaldi, Luigi Maria Edoardo, additional, Gross, Jeffrey, additional, Gross-Paju, Katrin, additional, Gudesblatt, Mark, additional, Guillaume, Daniel, additional, Haas, Judith, additional, Hancinova, Viera, additional, Hancu, Anca, additional, Hardiman, Orla, additional, Harmjanz, Arndt, additional, Heidenreich, Fedor R, additional, Hengstman, G J D, additional, Herbert, Joseph, additional, Herring, Mark, additional, Hodgkinson, Suzanne, additional, Hoffmann, Olaf M, additional, Hofmann, Werner E, additional, Honeycutt, William D, additional, Hua, Le Hanh, additional, Huang, Dehui, additional, Huang, Yining, additional, Huang, DeRen, additional, Hupperts, Raymond, additional, Imre, Piroska, additional, Jacobs, Alan Keith, additional, Jakab, Gabor, additional, Jasinska, Elzbieta, additional, Kaida, Kenichi, additional, Kalnina, Jolanta, additional, Kaprelyan, Ara, additional, Karelis, Guntis, additional, Karussis, Dimitrios, additional, Katz, Amos, additional, Khabirov, Farit A, additional, Khatri, Bhupendra, additional, Kimura, Takashi, additional, Kister, Ilya, additional, Kizlaitiene, Rasa, additional, Klimova, Eleonora, additional, Koehler, Juergen, additional, Komatineni, Aparna, additional, Kornhuber, Anselm, additional, Kovacs, Krisztina, additional, Koves, Agnes, additional, Kozubski, Wojciech, additional, Krastev, Georgi, additional, Krupp, Lauren B, additional, Kurca, Egon, additional, Lassek, Christoph, additional, Laureys, Guy, additional, Lee, Liesly, additional, Lensch, Eckart, additional, Leutmezer, Fritz, additional, Li, Hongzeng, additional, Linker, Ralf A, additional, Linnebank, Michael, additional, Liskova, Petra, additional, Llanera, Cristina, additional, Lu, Jiahong, additional, Lutterotti, Andreas, additional, Lycke, Jan, additional, Macdonell, Richard, additional, Maciejowski, Maciej, additional, Maeurer, Mathias, additional, Magzhanov, Rim V, additional, Maida, Eva-Maria, additional, Malciene, Lina, additional, Mao-Draayer, Yang, additional, Marfia, Girolama Alessandra, additional, Markowitz, Clyde, additional, Mastorodimos, Vasileios, additional, Matyas, Klotild, additional, Meca-Lallana, Jose, additional, Merino, Juan Antonio Garcia, additional, Mihetiu, Ioan Gheorghe, additional, Milanov, Ivan, additional, Miller, Aaron E, additional, Millers, Andrejs, additional, Mirabella, Massimiliano, additional, Mizuno, Masanori, additional, Montalban, Xavier, additional, Montoya, Lilina, additional, Mori, Masahiro, additional, Mueller, Stefanie, additional, Nakahara, Jin, additional, Nakatsuji, Yuji, additional, Newsome, Scott, additional, Nicholas, Richard, additional, Nielsen, A Scott, additional, Nikfekr, Esmaeil, additional, Nocentini, Ugo, additional, Nohara, Chiyoko, additional, Nomura, Kyoichi, additional, Odinak, Miroslav M, additional, Olsson, Tomas, additional, van Oosten, B W, additional, Oreja-Guevara, Celia, additional, Oschmann, Patrick, additional, Overell, James, additional, Pachner, Andrew, additional, Panczel, Gyula, additional, Pandolfo, Massimo, additional, Papeix, Caroline, additional, Patrucco, Liliana, additional, Pelletier, Jean, additional, Piedrabuena, Raul, additional, Pless, Misha, additional, Polzer, Udo, additional, Pozsegovits, Krisztian, additional, Rastenyte, Daiva, additional, Rauer, Sebastian, additional, Reifschneider, Gerd, additional, Rey, Roberto, additional, Rizvi, Syed A, additional, Robertson, Derrick, additional, Rodriguez, Jose Martinez, additional, Rog, David, additional, Roshanisefat, Homayoun, additional, Rowe, Vernon, additional, Rozsa, Csilla, additional, Rubin, Susan, additional, Rusek, Stanislaw, additional, Saccà, Francesco, additional, Saida, Takahiko, additional, Salgado, Antonio Vasco, additional, Sanchez, Victoria Eugenia Fernandez, additional, Sanders, Kalina, additional, Satori, Maria, additional, Sazonov, Denis V, additional, Scarpini, Elio Angelo, additional, Schlegel, Eugen, additional, Schluep, Myriam, additional, Schmidt, Stephan, additional, Scholz, Erich, additional, Schrijver, H M, additional, Schwab, Matthias, additional, Schwartz, Raymond, additional, Scott, James, additional, Selmaj, Krzysztof, additional, Shafer, Stuart, additional, Sharrack, Basil, additional, Shchukin, Ivan A, additional, Shimizu, Yuko, additional, Shotekov, Penko, additional, Siever, Arno, additional, Sigel, Karl-Otto, additional, Silliman, Scott, additional, Simo, Magdolna, additional, Simu, Mihaela, additional, Sinay, Vladimiro, additional, Siquier, Antonio Escartin, additional, Siva, Aksel, additional, Skoda, Ondrej, additional, Solomon, Andrew, additional, Stangel, Martin, additional, Stefoski, Dusan, additional, Steingo, Brian, additional, Stolyarov, Igor D, additional, Stourac, Pavel, additional, Strassburger-Krogias, Katrin, additional, Strauss, Erik, additional, Stuve, Olaf, additional, Tarnev, Ivaylo, additional, Tavernarakis, Antonios, additional, Tello, Cristina Ramo, additional, Terzi, Murat, additional, Ticha, Veronika, additional, Ticmeanu, Marina, additional, Tiel-Wilck, Klaus, additional, Toomsoo, Toomas, additional, Tubridy, Niall, additional, Tullman, Mark J, additional, Tumani, Hayrettin, additional, Turcani, Peter, additional, Turner, Ben, additional, Uccelli, Antonio, additional, Urtaza, Francisco Javier Olascoaga, additional, Vachova, Marta, additional, Valikovics, Attila, additional, Walter, Silke, additional, Van Wijmeersch, Bart, additional, Vanopdenbosch, Ludo, additional, Weber, Joerg R, additional, Weiss, Sara, additional, Weissert, Robert, additional, West, Timothy, additional, Wiendl, Heinz, additional, Wiertlewski, Sandrine, additional, Wildemann, Brigitte, additional, Willekens, Barbara, additional, Visser, L H, additional, Vorobeychik, Galina, additional, Xu, Xianhao, additional, Yamamura, Takashi, additional, Yang, Yi N, additional, Yelamos, Sergio Martinez, additional, Yeung, Michael, additional, Zacharias, Alan, additional, Zelkowitz, Marvin, additional, Zettl, Uwe, additional, Zhang, Meini, additional, Zhou, Hongyu, additional, Zieman, Ulf, additional, and Ziemssen, Tjalf, additional
Published: 2018
Full Text: View/download PDF

48. Discrepancies between urinary symptoms assessment and objective bladder dysfunctions in multiple sclerosis

Author: Haggiag, Shalom, primary, Bolla, Giovanni, additional, Picconi, Orietta, additional, Galgani, Simonetta, additional, and Gasperini, Claudio, additional
Published: 2017
Full Text: View/download PDF

49. Identifying Relapses in Multiple Sclerosis Patients through Administrative Data: A Validation Study in the Lazio Region, Italy

Author: Colais, Paola, Agabiti, Nera, Davoli, Marina, Buttari, Fabio, Centonze, Diego, De Fino, Chiara, Di Folco, Marta, Filippini, Graziella, Francia, Ada, Galgani, Simonetta, Gasperini, Claudio, Giuliani, Manuela, Mirabella, Massimiliano, Nociti, Viviana, Pozzilli, Carlo, Bargagli, Annamaria, Mirabella, Massimiliano (ORCID:0000-0002-7783-114X), Nociti, Viviana (ORCID:0000-0002-4607-3948), Colais, Paola, Agabiti, Nera, Davoli, Marina, Buttari, Fabio, Centonze, Diego, De Fino, Chiara, Di Folco, Marta, Filippini, Graziella, Francia, Ada, Galgani, Simonetta, Gasperini, Claudio, Giuliani, Manuela, Mirabella, Massimiliano, Nociti, Viviana, Pozzilli, Carlo, Bargagli, Annamaria, Mirabella, Massimiliano (ORCID:0000-0002-7783-114X), and Nociti, Viviana (ORCID:0000-0002-4607-3948)
Abstract: Background: Relapse is frequently considered an outcome measure of disease activity in relapsing-remitting multiple sclerosis (MS). The objectives of this study were to identify relapse episodes in patients with MS in the Lazio region using health administrative databases and to evaluate the validity of the algorithm using patients enrolled at MS treatment centers. Methods: MS cases were identified in the period between January 1, 2006 and December 31, 2009 using data from regional Health Information Systems (HIS). An algorithm based on HIS was used to identify relapse episodes, and patients recruited at MS centers were used to validate the algorithm. Positive and negative predictive values (PPV, NPV) and the Cohen's kappa coefficient were calculated. Results: The overall MS population identified through HIS consisted of 6,094 patients, of whom 67.1% were female and the mean age was 41.5. Among the MS patients identified by the algorithm, 2,242 attended the centers and 3,852 did not. The PPV was 58.9%, the NPV was 76.3%, and the kappa was 0.36. Conclusions: The proposed algorithm based on health administrative databases does not seem to be able to reliably detect relapses; however, it may be a helpful tool to detect healthcare utilization, and therefore to identify the worsening condition of a patient's health.
Published: 2017

50. Real-world effectiveness of natalizumab and fingolimod compared with self-injectable drugs in non-responders and in treatment-naïve patients with multiple sclerosis

Author: Prosperini, Luca, primary, Saccà, Francesco, additional, Cordioli, Cinzia, additional, Cortese, Antonio, additional, Buttari, Fabio, additional, Pontecorvo, Simona, additional, Bianco, Assunta, additional, Ruggieri, Serena, additional, Haggiag, Shalom, additional, Brescia Morra, Vincenzo, additional, Capra, Ruggero, additional, Centonze, Diego, additional, Di Battista, Giancarlo, additional, Ferraro, Elisabetta, additional, Francia, Ada, additional, Galgani, Simonetta, additional, Gasperini, Claudio, additional, Millefiorini, Enrico, additional, Mirabella, Massimiliano, additional, and Pozzilli, Carlo, additional
Published: 2016
Full Text: View/download PDF

Catalog

Books, media, physical & digital resources

See catalog results

Searchworks

Select search scope, currently: Articles Catalog books, media & more in Jio Institute collections Articles journal articles & other e-resources

Search

Search Constraints

Refine your results

Search Limiters

Topic

Publication Year Range

Language

Publication Type

Journal

Region

Database

Publisher

175 results on '"Galgani, Simonetta"'

Search Results

Catalog

Select search scope, currently: Articles

Catalog

books, media & more in Jio Institute collections

Articles

journal articles & other e-resources