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Objective: The present study evaluated the near (attention) and far (reading, ADHD symptoms, learning, and quality of life) transfer effects of a Computerized Progressive Attention Training (CPAT) versus Mindfulness Based Stress Reduction (MBSR) practice among adults with ADHD compared to a passive group. Method: Fifty-four adults participated in a non-fully randomized controlled trial. Participants in the intervention groups completed eight 2-hr weekly training sessions. Outcomes were assessed before, immediately after, and 4 months post-intervention, using objective tools: attention tests, eye-tracker, and subjective questionnaires. Results: Both interventions showed near-transfer to various attention functions. The CPAT produced far-transfer effects to reading, ADHD symptoms, and learning while the MBSR improved the self-perceived quality of life. At follow-up, all improvements except for ADHD symptoms were preserved in the CPAT group. The MBSR group showed mixed preservations. Conclusion: Both interventions have beneficial effects, however only the CPAT group exhibited improvements compared to the passive group.

Exciton dynamics, lifetimes, and scattering are directly related to the exciton dispersion or band structure. Here, we present a general theory for exciton band structure within both ab initio and model Hamiltonian approaches. We show that contrary to common assumption, the exciton band structure contains nonanalytical discontinuities-a feature which is impossible to obtain from the electronic band structure alone. These discontinuities are purely quantum phenomena, arising from the exchange scattering of electron-hole pairs. We show that the degree of these discontinuities depends on materials' symmetry and dimensionality, with jump discontinuities occurring in 3D and different orders of removable discontinuities in 2D and 1D, whose details depend on the exciton degeneracy and material thickness. We connect these features to the early stages of exciton dynamics, radiative lifetimes, and diffusion constants, in good correspondence with recent experimental observations, revealing that the discontinuities in the band structure lead to ultrafast ballistic transport and suggesting that measured exciton diffusion and dynamics are influenced by the underlying exciton dispersion.

The current focus on power relationships in planning processes emphasizes socioeconomic characteristics of the general public, whose participation is often portrayed as one-time, idiosyncratic, non...

Despite the plethora of research on environmental participatory processes, the forms of nongovernmental organization (NGO) involvement in these processes, and the influence of their involvement on participation outcomes, are still under-conceptualized. This article aims to develop a conceptual typology for NGO roles in environmental participatory processes and to suggest how these roles might be associated with participation outcomes. Following a review of public participation literature and NGO capacities, we present four prototypes of NGO roles along two axes: orientation axis and nature of involvement axis. The prototypes include Entrepreneur, Service-Provider, Enabler, and Partner. We then offer an empirical illustration of the typology using eight case studies across the globe and discuss how the four NGO roles might be associated with outcomes of participatory processes. The framework acknowledges the complex, sometimes limited, contribution of NGOs to participatory processes and suggests practical implications.

Differentiation therapy has been recently revisited as a prospective approach in cancer therapy by targeting the aberrant growth, and repairing the differentiation and cell death programs of cancer cells. However, differentiation therapy of solid tumors is a challenging issue and progress in this field is limited. We performed High Throughput Screening (HTS) using a novel dual multiplex assay to discover compounds, which induce differentiation of human colon cancer cells. Here we show that the protein arginine methyl transferase (PRMT) type 1 inhibitor, MS023, is a potent inducer of colon cancer cell differentiation with a large therapeutic window. Differentiation changes in the highly aggressive human colon cancer cell line (HT-29) were proved by proteomic and genomic approaches. Growth of HT-29 xenograft in nude mice was significantly delayed upon MS023 treatment and immunohistochemistry of tumor indicated differentiation changes. These findings may lead to development of clinically effective anti-cancer drugs based on the mechanism of cancer cell differentiation.

Deliberative democracy fosters greater involvement of the public in policymaking. However, psychological challenges involved in eliciting policy preferences receive little attention in this context. This study addresses the implications of opportunity cost neglect (OCN) and impact bias for policy preferences. Utilizing a survey experiment among residents of peripheral towns in Israel, we examine preferences regarding investment in rail infrastructure in peripheral areas. In line with psychological studies on OCN, we find evidence that priming awareness to alternatives can de-bias OCN in policy preferences. However, this method is less effective for people who exhibit impact bias (respondents for whom the policy is new), presenting a serious challenge to the validity of policy preferences of those who are expected to be most affected by the considered policy. This paper offers a theoretical contribution to the relationship between OCN and impact bias, and discusses the practical implications for public participation in policymaking.

Designing covalent inhibitors is increasingly important, although it remains challenging. Here, we present covalentizer, a computational pipeline for identifying irreversible inhibitors based on structures of targets with non-covalent binders. Through covalent docking of tailored focused libraries, we identify candidates that can bind covalently to a nearby cysteine while preserving the interactions of the original molecule. We found ∼11,000 cysteines proximal to a ligand across 8,386 complexes in the PDB. Of these, the protocol identified 1,553 structures with covalent predictions. In a prospective evaluation, five out of nine predicted covalent kinase inhibitors showed half-maximal inhibitory concentration (IC50) values between 155 nM and 4.5 μM. Application against an existing SARS-CoV Mpro reversible inhibitor led to an acrylamide inhibitor series with low micromolar IC50 values against SARS-CoV-2 Mpro. The docking was validated by 12 co-crystal structures. Together these examples hint at the vast number of covalent inhibitors accessible through our protocol., Graphical Abstract, Designing covalent inhibitors is a challenging task. Covalentizer is a computational pipeline for identifying irreversible inhibitors based on known non-covalent binders. Within the PDB, Zaidman and Gehrtz et al. identified >1,553 structures with covalent predictions, leading to the discovery of covalent kinase inhibitors and an inhibitor of SARS-CoV-2 Mpro.

Herein we provide a living summary of the data generated during the COVID Moonshot project focused on the development of SARS-CoV-2 main protease (Mpro) inhibitors. Our approach uniquely combines crowdsourced medicinal chemistry insights with high throughput crystallography, exascale computational chemistry infrastructure for simulations, and machine learning in triaging designs and predicting synthetic routes. This manuscript describes our methodologies leading to both covalent and non-covalent inhibitors displaying protease IC50 values under 150 nM and viral inhibition under 5 uM in multiple different viral replication assays. Furthermore, we provide over 200 crystal structures of fragment-like and lead-like molecules in complex with the main protease. Over 1000 synthesized and ordered compounds are also reported with the corresponding activity in Mpro enzymatic assays using two different experimental setups. The data referenced in this document will be continually updated to reflect the current experimental progress of the COVID Moonshot project, and serves as a citable reference for ensuing publications. All of the generated data is open to other researchers who may find it of use.

Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is threatening public health as it spreads worldwide across diverse environments. Its genetic hallmark, the mecA gene, confers resistance to many β-lactam antibiotics. Here, we show that, in addition, mecA provides a broad selective advantage across diverse chemical environments. Competing fluorescently labelled wild-type and mecA-deleted CA-MRSA USA400 strains across ~57,000 compounds supplemented with subinhibitory levels of the β-lactam drug cefoxitin, we find that mecA provides a widespread advantage across β-lactam and non β-lactam antibiotics, non-antibiotic drugs and even diverse natural and synthetic compounds. This advantage depends on the presence of cefoxitin and is strongly associated with the compounds’ physicochemical properties, suggesting that it may be mediated by differential compounds permeability into the cell. Indeed, mecA protects the bacteria against increased cell-envelope permeability under subinhibitory cefoxitin treatment. Our findings suggest that CA-MRSA success might be driven by a cell-envelope mediated selective advantage across diverse chemical compounds., The mecA gene confers resistance to many β-lactam antibiotics in community-associated MRSA bacteria. Here, Snitser et al. show that mecA also provides broad selective advantage across diverse chemical environments in the presence of subinhibitory β-lactam concentrations, by protecting the bacteria against increased cell-envelope permeability.

The COVID-19 pandemic was a stark reminder that a barren global antiviral pipeline has grave humanitarian consequences. Pandemics could be prevented in principle by accessible, easily deployable broad-spectrum oral antivirals. Here we report the results of theCOVID Moonshot, a fully open-science, crowd sourced, structure-enabled drug discovery campaign targeting the SARS-CoV-2 main protease. We discovered a novel chemical series that is differentiated from current Mpro inhibitors in that it maintains a new non-covalent, non-peptidic scaffold with nanomolar potency. Our approach leveraged crowdsourcing, high-throughput structural biology, machine learning, and exascale molecular simulations and high-throughput chemistry. In the process, we generated a detailed map of the structural plasticity of the SARS-CoV-2 main protease, extensive structure-activity relationships for multiple chemotypes, and a wealth of biochemical activity data. In a first for a structure-based drug discovery campaign, all compound designs (>18,000 designs), crystallographic data (>840 ligand-bound X-ray structures), assay data (>10,000 measurements), and synthesized molecules (>2,400 compounds) for this campaign were shared rapidly and openly, creating a rich open and IP-free knowledgebase for future anti-coronavirus drug discovery.

Designing covalent inhibitors is a task of increasing importance in drug discovery. Efficiently designing irreversible inhibitors, though, remains challenging. Here, we present covalentizer, a computational pipeline for creating irreversible inhibitors based on complex structures of targets with known reversible binders. For each ligand, we create a custom-made focused library of covalent analogs. We use covalent docking, to dock these tailored covalent libraries and to find those that can bind covalently to a nearby cysteine while keeping some of the main interactions of the original molecule. We found ~11,000 cysteines in close proximity to a ligand across 8,386 protein-ligand complexes in the PDB. Of these, the protocol identified 1,553 structures with covalent predictions. In prospective evaluation against a panel of kinases, five out of nine predicted covalent inhibitors showed IC50 between 155 nM - 4.2 μM. Application of the protocol to an existing SARS-CoV-1 Mpro reversible inhibitor led to a new acrylamide inhibitor series with low micromolar IC50 against SARS-CoV-2 Mpro. The docking prediction was validated by 11 co-crystal structures. This is a promising lead series for COVID-19 antivirals. Together these examples hint at the vast number of covalent inhibitors accessible through our protocol.

This paper reports on the Israeli experience with a high-occupancy toll (HOT) lane between Jerusalem and Tel Aviv. It highlights the integration of a park-and-ride service with the HOT lane and the provision of free parking to encourage carpooling. The paper also analyses Israel’s pilot “Going Green” programme and how it demonstrates the potential of positive incentives to address congestion.

Kidney failure is frequently observed during and after COVID-19, but it remains elusive whether this is a direct effect of the virus. Here, we report that SARS-CoV-2 directly infects kidney cells and is associated with increased tubule-interstitial kidney fibrosis in patient autopsy samples. To study direct effects of the virus on the kidney independent of systemic effects of COVID-19, we infected human induced pluripotent stem cell-derived kidney organoids with SARS-CoV-2. Single cell RNA-sequencing indicated injury and dedifferentiation of infected cells with activation of pro-fibrotic signaling pathways. Importantly, SARS-CoV-2 infection also led to increased collagen 1 protein expression in organoids. A SARS-CoV-2 protease inhibitor was able to ameliorate the infection of kidney cells by SARS-CoV-2. Our results suggest that SARS-CoV-2 can directly infect kidney cells and induce cell injury with subsequent fibrosis. These data could explain both acute kidney injury in COVID-19 patients and the development of chronic kidney disease in Long-COVID., Graphical Abstract, Jansen, Reimer, Nagai et al report that SARS-CoV-2 infects kidney cells and is associated with kidney fibrosis in patients. Using single cell transcriptomics of infected kidney organoids, they show that SARS-CoV-2 causes kidney injury and stimulates pro-fibrotic signaling. Viral infection in organoids was inhibited by a recently developed protease blocker.

Israeli politicians strongly support inter-urban rail investment and network development connecting peripheral localities, while transport experts voice criticism and oppose many of the planned investments. This study focuses on the lacuna in transportation scholarship regarding elected officials' expectations from rail investment in peripheral areas and its potential to reduce spatial disparities, stressing that there is little research effort to reveal the reasoning of politicians when promoting transport investment and the extent to which some of the political considerations may reflect an authentic representation of public sentiments. First, an explorative qualitative study was conducted, using multiple data sets, including 12 in-depth interviews with elected officials and transport decision makers, newspaper articles, and professional documents. Analysis identified four main themes with conflicting perspectives between transport experts and politicians: Marginal vis-a-vis revolutionary effects; daily vis-a-vis less frequent activities; transport link vis-a-vis emotional link and social justice vis-a-vis social commitment. These themes reflect the tension between the discourse of accessibility led by experts and the implied discourse of mobility by politicians. The second stage was based on a large scale survey of 2008 respondents from peripheral and central localities in Israel, aimed at revealing public beliefs and preferences regarding rail investment in peripheral localities. Results showed that differences of opinion between experts and politicians do not stem only from political bias or irrelevant interests but reflect experts' inability to consider benefits that are appreciated by both politicians and the general public. The study also draws attention to different approaches to the goals of transportation systems. While the dominant voice in scholarly discourse considers accessibility gains as the main goal of transport policy, both elected politicians and residents from peripheral localities also appreciate mobility gains.

Polyacrylonitrile–phenolic composites display excellent in-plane properties but perform poorly when out-of-plane, through-thickness properties are considered. Composite architectures with carbon nanotubes, either dispersed within the matrix or bound to a fabric, in traditional composites have the potential to alleviate this weakness. However, effective reinforcement of composites using carbon nanotubes is difficult, due to poor dispersion and interfacial stress transfer and has thus far been met with limited success and at high costs. This paper describes an innovative and cost-effective technology to improve these inferior mechanical properties by using an exceptionally stable protein, SP1, for CNT attachment to PAN fabric, forming a three-dimensional nano-reinforced structure. This work confirms remarkable improvements in interlaminar shear strength and through-thickness tensile strength of SP1/CNT-reinforced polyacrylonitrile composites.

Given the potential for uncertainties to influence mega-projects, this study examines how mega-projects are deliberated in the public arena. The paper traces the strategies used to promote the Dead Sea Water Canal. Findings show that the Dead Sea mega-project was encumbered by ample uncertainties. Treatment of uncertainties in early coverage was dominated by economics and raised primarily by politicians, while more contemporary media discourses have been dominated by ecological uncertainties voiced by environmental non-governmental organizations. This change in uncertainty type is explained by the changing nature of the project and by shifts in societal values over time. The study also reveals that ‘uncertainty reduction’ and to a lesser degree, ‘project cancellation’, are still the strategies most often used to address uncertainties. Statistical analysis indicates that although uncertainties and strategies are significantly correlated, there may be other intervening variables that affect this correlation. This research also therefore contributes to wider and ongoing considerations of uncertainty in the public arena through various media representational practices.

Information and communication technologies (ICTs) are hypothesized to replace or change the use of the transport system by facilitating new or different activities. This article offers a review of more than 40 years of research regarding the relationship between ICTs and urban mobility. We discuss the expectations for the changes in travel demand, travel patterns, and the urban form as a result of the development and introduction of ICTs. Much of the interest in the relationships between ICTs and mobility is premised on the expectation of substitution effects, but empirical findings often suggest more complex effects than direct substitution. Although research on single types of travel activity may sometimes indicate simple substitution effects, examination of the broader impacts may also reveal travel generation effects as well. As such, ICTs do not simply substitute mobility patterns but change them. A growing body of research focuses on changing mobility patterns (in terms of time and space), c...

It is often non-governmental organizations (NGOs) that promote empoweredparticipation processes, and assume active roles in leading them. However, the ability ofNGOs to take on such processes is under-theorized. In many cases empoweredparticipation involving NGOs takes place without political support from above (or withlimited or conditional support). Our goal in this article is to use a case study ofparticipatory planning in East Jerusalem to theorize processes of empowerment in anoppositional political environment. We argue that it is useful to analyze such processesof empowered participation through the concept of power. We describe the process ofempowerment as a speculative process in which the NGO has to hedge two mediums ofpower: it has to build the power of the community to discuss its own goals; and it has tosimultaneously manage the transfer of decision-making power from government bodiesto the community.

Forecasting the impacts of a proposed policy is an important component of the transportation planning and decision making process. Although scientific tools are often used in transportation forecasts, biases and, more specifically, overestimations of the expected impact are often observed. This study explores the correlations between forecast-maker’s characteristics and forecast bias creation and reduction. The study examines two transport-related policies aiming at the reduction of car use: telecommuting and carsharing. Both are Travel Demand Management (TDM) policies, which attract much attention from transport experts. We tested the extent to which the forecast-maker’s beliefs about the policy at stake affected the forecast bias. We found that attitudes and beliefs associates not only with overestimation bias but also with its reduction over time. We also tested the extent to which the forecast-maker’s affiliation, the performing institute and the publication type were correlated with the biases of the forecast and with the forecaster attitudes and beliefs. These characteristics are intuitively used by the forecast user as tools to assess the ‘objectivity’ of the forecast, but our analysis found no association between these characteristics and the forecast bias.

Both advocates and critics of deliberative planning often study deliberative planning processes as if they are real-life approximations of an ideal situation where the only force is the force of the better argument. However, in the course of the last decade democratic theorists came to develop a complex systemic understanding of the role of deliberation in policy making. In this view, legitimate decision making is not a one-time process but an ongoing pattern of interaction between organized institutions and the public sphere. This paper builds on recent work on political representation to develop a framework for studying deliberative planning as a type of representative claim made within a complex ecology of representative institutions and applies this framework to the case of a deliberative planning initiative in East Jerusalem. We examine the weaknesses and strengths of deliberative planning processes in a political environment that is not hospitable to public participation in planning.

Decisions to fund light rail (LRT) have been critiqued as instrumentally irrational. This paper examines whether the seemingly more technical LRT routing decisions are instrumentally rational. To this end, we test whether routing decisions are made to address goals that are rationally derived from the challenges faced by the urban region. On the basis of a review of the literature, two rationales that underlie most of the stated goals are identified: providing service for the most heavily travelled and congested corridors and inducing development, and subsequently demand, in areas perceived to be underdeveloped or distressed and in areas that have deteriorated. In a survey of key respondents from 16 cities, we find that goals are only weakly correlated with the challenges. While most routes provide service on the most heavily demanded corridors, routing decisions are no less driven by a desire to cut pecuniary and transaction costs. For this reason existing rights of way are often preferred. This is explained by the intertwining of routing and funding decisions. The implications of these findings for evaluation techniques of LRT routes are discussed.

Many sustainable urban development approaches are based on mass public transportation ventures, especially railway development, which has been considered a panacea for the unfavorable effects of suburban development. But rail transit also improves accessibility to the fringes, thus encouraging an exodus to the suburbs. This paper explores suburbanization and sprawling effect of commuter rail transit on the rural exurbia of the Tel Aviv metropolis by analyzing its effect on residential location decisions. The findings indicate that the suburban rail system was a determinant factor in the location choice of households which migrated from the inner parts of the Tel Aviv metropolis, since it allowed them to maintain strong commuting connections to their residential origin. This suggests that rail transit, along with its potential to strengthen the inner cities, also accelerates suburbanization and counter urbanization.

Diaphyseal bone from normal Sprague-Dawley rats was delipidated in chloroform-methanol and demineralized in 0.6 N HCl at 4 degrees C. The bones were then implanted for 7-28 days into rats made rachitic by a low-phosphate, vitamin D-deficient diet (VDP-) for 3 weeks. Bones from VDP- and normal rats were also implanted into normal hosts. When normal rats were used as the host environment, a consistent sequence of cartilage induction and bone formation was observed. Demineralized rachitic bone (RB) implanted into normal host rats resulted in cartilage and bone induction similar to that seen for normal bone (NB) implants. Transmission electron microscopy of RB in normal hosts revealed morphologically normal chondrocytes and cartilage matrix with normal mineralization. In contrast, implantation of NB in VDP- hosts resulted in delayed chondrogenesis and lack of calcification. Furthermore, similar results were observed when RB was implanted into VDP- hosts. Treatment of VDP- hosts with either 1 alpha-hydroxyvitamin D3 or 24,25-dihydroxyvitamin D3 did not accelerate the sequential appearance of precartilage or cartilage. However, 24,25-(OH)2D3 administered alone or in combination with 1 alpha-OHD3 significantly increased the amount of calcified cartilage observed at 2 weeks postimplantation compared to implants from either untreated VDP-hosts or those treated only with 1 alpha-OHD3. New bone formation was observed at 4 weeks postimplantation in all vitamin D-treated groups as determined by von Kossa staining or direct electron microscope examination. There was no apparent difference in the quantitative or qualitative bone formed within the various vitamin D-treated groups. Serum calcium and phosphorus levels were lower and alkaline phosphatase levels were higher in VDP- hosts compared with normal animals or those treated with vitamin D metabolites. The results of this study show a reduction in the capacity of progenitor cells in VDP- rat hosts to respond to osteoinductive factor(s). This impaired response appears to be corrected by vitamin D metabolites.

Economic tools, include a number of tax-related tools, are often seen as efficient and effective transport-environmental policy tools. However, since tax policies are usually under the authority of non-transport actors, transport-environmental policy makers face a major challenge in mobilizing these actors to promote policies that conform with transport-environmental goals. The challenge can be regarded as a framing exercise since it affects the public debate, the rhetoric against and for the policy, the coalition structure and the likelihood of promoting and implementing the policy. To demonstrate the importance of policy framing, this paper examines the case of Israel's taxation policy on company cars and the efforts to increase these taxes. The policy proposal was framed as a fiscal policy. Both institutional and public discourse concentrated on tax issues and transport and environmental issues were hardly raised. Tradeoffs exist between different choices of policy framing and there is a need to distinguish between institutional framing and public framing.

Transportation analysis emphasizes the necessity to internalize the transport externalities of car usage through taxation. Yet taxation decisions are often made with non-transport goals in mind. In such cases, transport policies are made ‘by the way.’ This paper examines such a case: Israel’s taxation policy on company cars. It shows that current taxation policies result in increasing numbers of company cars and growing numbers of transport users who are not sensitive to the marginal cost of car use and make excessive use of the car. As a result, a significant portion of Travel Demand Management (TDM) measures cannot affect this group. The Israeli case of company car tax reform demonstrates the problematic effect of a policy that does not take its overall consequences on other policy fields into account and thereby impairs efforts to reduce the negative impacts of the transport system. Also, it demonstrates the importance of institutional aspects of transport policymaking.

Intraoral local anesthesia is essential for delivering dental care. However, it is often perceived by some patients as the most painful and in some instances as the only painful part of the treatment, leading in extreme cases to avoidance of dental care. The present study measured the variables of pain, pressure, and discomfort caused by 4 commonly used local anesthesia injections: local infiltration, mental nerve block, inferior alveolar nerve block, and periodontal ligament injections. Patients were asked to grade pain, discomfort, and pressure on a visual analog scale as associated with needle insertion, operator finger position in the mouth, and pressure at injection. The inferior alveolar injection was graded to be the most painful followed by periodontal ligament and then mental nerve block injections. The periodontal ligament injections yielded the highest pressure scores. The inferior alveolar block injection yielded significantly more discomfort than local infiltration and mental nerve block injections when comparing finger and needle position. Local infiltration in the anterior maxillary region yielded the highest needle insertion and finger position discomfort scores. The present study suggests that the dental operator should be aware of local anesthesia injection pain, pressure, and discomfort together with efficacy of technique.

Information and Communication Technologies (ICT) have become important tools to promote an achieve a variety of public goals and policies. The growing importance of ICT in daily life, business activities and governance prompts the need to consider the role of ICT more explicitly in urban administrations and policies. What are the city-makers' expectations of ICT? And how do they assess the future implications of ICT for their city? An analysis of these questions is needed to provide us with a better understanding of the extent to which urban authorities are willing to invest in, and to adopt, ICT policy. This paper offers both a conceptual and an operational model that aims to map out the causes and implications of ICT perceptions and views of urban policy-makers and/or administrative officials (denoted as urban front-liners). This is followed by the presentation of an operational path model-i.e. a linear structural equations model (Lisrel). The model serves to describe and test the relationships between perceptions of the city, policy-makers' beliefs about ICT and the associated urban ICT policy. According to the model, respondents who perceive their city as having many urban functions (such as commercial centre, service centre, higher education centre) have more awareness of various ICT tools and are likely to consider a multiplicity of ICT measures as relevant to their city. Respondents who consider their city as having severe bottlenecks (such as traffic congestion, housing shortage) are less likely to think of ICT measures and ICT-related goals as relevant to their city, and nor do they think that the municipality impacts significantly on ICT in the city. Furthermore, respondents who perceive their city as suffering from many socioeconomic problems (unemployment, ageing population, industrial decline and so on) are likely to consider many ICT tools as relevant to their city, although they have a low awareness of the specific tools to be deployed. Finally, respondents who believe that ICT will significantly (and positively) affect the city and its administration also tend to believe that the municipality has a high municipal influence on ICT and consider many ICT initiatives as relevant to their city. © 2004 The Editors of Urban Studies.

Information and Communication Technology (ICT) has become an important tool to promote a variety of public goals and policies. In the past years much attention has been given to the expected social benefits from deploying ICTs in different urban fields (transportation, education, public participation in planning, etc.) and to its potential to mitigate various current or emerging urban problems. The growing importance of ICTs in daily life, business activities, and governance prompts the need to consider ICTs more explicitly in urban policies. Alongside the expectation that the private sector will play a major role in the ICT field, the expected benefits from ICTs also encourage urban authorities to formulate proper public ICT policies. Against this background, various intriguing research questions arise. What are the urban policy-makers' expectations about ICTs? And how do they assess the future implications of ICTs for their city? A thorough analysis of these questions will provide a better understanding of the extent to which urban authorities are willing to invest in and to adopt a dedicated ICT policy. This study is focusing on the way urban decision-makers perceive the opportunities of ICT policy. After a sketch of recent development and policy issues, a conceptual model is developed to map out the driving forces of urban ICT policies in cities in Europe. Next, by highlighting the importance of understanding the decision-maker's "black box," three crucial variables are identified within this box. In the remaining part of the paper these three variables will be operationalized by using a large survey comprising more than 200 European cities. By means of statistical multivariate methods (i.e., factor and cluster analysis), the decision-makers were able to be characterized according to the way they perceive their city (the concept of "imaginable city"), their opinion about ICT, and the way they assess the relevance of ICT policies to their city. Next, a solid explanatory framework will be offered by using a log-linear logit analysis to test the relationships between these three aspects. © 2004 Gatton College of Business and Economics, University of Kentucky.

In the information society, information and communication technology (ICT) is potentially an important policy tool. Especially at local levels, scholars stress the essentiality of active intervention and use of ICT tools. However, since these technologies are still new, little experience exists relative to urban ICT initiatives. This paper therefore aims to examine the way urban front-liners (both elected politicians and administrative professionals) perceive the opportunities of urban ICT policy. Using a European survey, the authors researched views and beliefs about different aspects of urban ICT policies. Following that, they tested whether there is a relationship between the activity field of the respondents and their views on ICT policies. Significant differences among urban planners and economists were established.

Cities around the world attempt to imitate the Silicon Valley model by adopting public policies aimed at attracting new high-tech industries and Research and Development activities. The adoption of Information and Communications Technologies (ICT) as elements in a public policy is based on the expectations of policy-makers regarding the potential to harness technology to ameliorate key urban problems such as a deteriorating environment, congestion or lack of communications between citizens and institutions. More specifically, policy-makers are exposed to knowledge about ICT, which is supplied by a variety of sources like scientists, popular media and their own experience. This paper argues that two gaps typify the flow of knowledge consumed by urban decision-makers: the knowledge gap, namely the uncertainty about the actual impacts of ICT on urban issues, and the communication gap which relates to the biases and noise emanating from the process of communicating knowledge between different actors on potential ICT impacts. The communications gap can, to a large extent, be explained by language and cultural differences between scientists and policy-makers. To illustrate and emphasise the gaps and their role in the ICT policy-making process, in this paper a comparison is made with the more familiar case of transportation policy making.

Information and communication technology (ICT) is widely accepted as a potentially favourable set of instruments, which may improve the welfare and competitiveness of nations and cities. Nowadays, both public and private actors aim to exploit the expected benefits of ICT developments. The authors seek to investigate the potential of ICT use at an urban level and, in particular, to shed more light on various factors that influence urban ICT policies in the public domain. First, a conceptual framework, designed to improve understanding of the driving forces of urban ICT policies, is outlined. It focuses on the way decisionmakers perceive their city, and shape their opinions about ICT; it addresses in particular the way these decisionmakers evaluate the importance of ICT for their city. Next, interviews with urban decisionmakers in different European cities in three countries (Austria, Spain, and the Netherlands) are used to analyse the complex relationship between perceived urban characteristics (for example, nature of problems and urban image), personal attitudes towards ICT, administrative features of the cities concerned, and perceptions of the relevance of ICT to the cities. The authors' main focus is on the identification of a possible systematic relationship between the aforementioned explanatory factors and urban decisionmakers' attitudes towards ICT policies. Understanding the decisionmakers' perceptions is an important step towards grasping the nature and substance of the policy itself, and may explain some of the variance among different cities. Because the 'urban ICT' discourse is still relatively new, an open-interview method is used to capture a variety of different views and perceptions on ICT and on the information age in the city. With the aid of qualitative content analysis, the interview results are transformed into a more systematic and tlsb>comparable form. The results suggest that even interviewees from the same city may have a different understanding of their urban reality whereas, on the other hand, cities with different characteristics may appear to suffer from similar problems. Moreover, the authors found a wide range of attitudes toward ICT and its expected social impacts, although most of the interviewees appeared to be more sceptical than had been expected. The authors identified a clear need for a more thorough investigation of background factors and, therefore an approach originating from the field of artificial intelligence -- rough-set analysis -- was deployed to offer a more rigorous analysis. This approach helped in the characterisation and understanding of perceptions and attitudes regarding urban policies, problems, and images.

This paper evaluates lidocaine absorption via oral mucosa following its topical application for symptomatic treatment of bone marrow transplantation (BMT)-induced oral mucositis. Five patients with high-grade oral mucositis after allogeneic BMT were entered consecutively into the study. Five healthy individuals served as controls. All 10 participants rinsed their mouth with 5 ml of a 2% lidocaine solution for 1 min, after which they expectorated the liquid. Blood samples were drawn at 1, 5, 10, 20, 30 and 60 min after rinsing and centrifuged. Plasma lidocaine levels were measured by fluorescence polarization immunoassay. In the BMT patients, plasma lidocaine levels were lower than the therapeutic range of this drug (0.2 microg/ml vs 1.5-5.5 microg/ml), while in the controls no detectable lidocaine levels were noted. The data from this preliminary study indicate that lidocaine prescribed as an anesthetic mouthwash in BMT patients with oral mucositis results in minor systemic absorption of the drug.

This paper offers a critical review of current debates on the importance and the potential of ICT for modern cities. Much attention is given to the opportunities offered by local e-governance, as a systematic strategy to exploit the potential of ICT for the public domain in European cities. Since the views of many experts and elected policy-makers in cities (so-called ‘urban frontliners’) is coloured by subjective expectations and perceptions, we examine in particular the extent to which the expected influences of ICT, as perceived by urban frontliners, affect their perceptions of the relevance of ICT to mitigate contemporary urban challenges. The final (empirical) part of the paper addresses the issue of the systematic study of cyber perceptions of cities in Europe.

Information and Communication Technologies (ICT) have become important tools to promote a variety of public goals and policies. In the past years much attention has been given to the expected social benefits from deploying ICT in different fields (transportation, education, public participation in planning etc.) and to its potential to mitigate various current or emerging urban problems. The growing importance of ICT in daily life, business activities and governance prompts the need to consider ICT more explicitly in urban policies. Alongside the expectation that the private sector will play a major role in the ICT field, the expected benefits from ICT encourage also urban authorities to formulate proper public ICT policies.Against this background, various intriguing research questions arise. What are the urban policy-makers' expectations about ICT? And how do they assess the future implications of ICT for their city? An analysis of these questions will provide us with a better understanding of the extent to which urban authorities are willing to invest in and adopt a dedicated ICT policy.This paper is focusing on the way urban decision-makers perceive the opportunities of ICT policy. First, a conceptual model is developed to explain the driving forces of urban ICT policies in European cities. Next, by highlighting the importance of understanding the decision-maker's "black box", we identify three crucial variables within this box. In the remaining of the paper we will give an operational meaning to these three variables by using a survey comprising more than 200 European cities . By using statistical multivariate methods (i.e., factor and cluster analysis), we were able to characterize the decision-makers according to the way they perceive their city (the "imaginable city"), their opinion about ICT and the way they asses the relevance of ICT policies to their city.

With the rising importance of environmental quality the primary goal of transportation policies is increasingly defined as sustainable mobility. However, the concept of sustainability does not only refer to the natural environment. Transport policies need to accommodate, to varying de-grees, three objectives: economic growth, social equity and environmental sustainability. The challenge of policy formulation is complicated by the fact that all three objectives are themselves multi-dimensional. The costs and benefits of policy measures to promote sustainable mobility in cities are likely to be differentially distributed across different segments of the population based on location, socio-demographic and economic characteristics, behavioural patterns (including travel behaviour) and demand attributes. Discrete measures designed to benefit one group often adversely affect others. Spillover effects occur between spatial units and on a temporal dimen-sion. There are positive synergies between some policies, whereas other policies cancel each other out. Thus there is a great societal benefit in designing harmonised, comprehensive policy packages to promote sustainable mobility

The impact of transport on the environment is a major issue of worldwide concern. This important new book presents state-of-the-art contributions on spatial and technological aspects of transport in relation to environmental degradation, together with analysis of sustainable transport policy.

In our modern network world, ICT acts as a connecting and integratingmechanism. Information (data, knowledge)has become a core constellation in an open economy. The avalanche ofinformation supply however, has not keptpace with the use of information by decision-making bodies.Especially in the public domain we observe often aninsurmountable gap. The actual use of opportunities offered by theICT sector to the public domain isdisappointingly low. The paper sets out to explain the existence ofimpediments in information acceptance and usein urban policy making. Particular attention will be given to theperception of the information potential by planners,experts and decision-makers. In this respect various constraintsexist in terms of lack of awareness of ICT policies,and lack of consensus about goals and means of ICT policies. Theanalysis will be illustrated by reference to aDutch study on the role of the advanced information sector in modernurban planning and administration.