1,745 results on '"Galli, F"'
Search Results
2. Holographic pump probe spectroscopy
- Author
-
Bagrov, A., Craps, B., Galli, F., Keränen, V., Keski-Vakkuri, E., and Zaanen, J.
- Subjects
High Energy Physics - Theory ,Condensed Matter - Strongly Correlated Electrons ,Condensed Matter - Superconductivity ,Quantum Physics - Abstract
We study the non-linear response of a 2+1 dimensional holographic model with weak momentum relaxation and finite charge density to an oscillatory electric field pump pulse. Following the time evolution of one point functions after the pumping has ended, we find that deviations from thermality are well captured within the linear response theory. For electric pulses with a negligible zero frequency component the response approaches the instantaneously thermalizing form typical of holographic Vaidya models. We link this to the suppression of the amplitude of the quasinormal mode that governs the approach to equilibrium. In the large frequency limit, we are also able to show analytically that the holographic geometry takes the Vaidya form. A simple toy model captures these features of our holographic setup. Computing the out-of-equilibrium probe optical conductivity after the pump pulse, we similarly find that for high-frequency pulses the optical conductivity reaches its final equilibrium value effectively instantaneously. Pulses with significant DC components show exponential relaxation governed by twice the frequency of the vector quasinormal mode that governs the approach to equilibrium for the background solution. We explain this numerical factor in terms of a simple symmetry argument., Comment: 43 pages, 13 figures, companion paper of arXiv:1708.08279; v2: clarifications and reference added, minor typos corrected, published version
- Published
- 2018
- Full Text
- View/download PDF
3. Final results of DIADEM, a phase II study to investigate the efficacy and safety of durvalumab in advanced pretreated malignant pleural mesothelioma
- Author
-
Cortinovis, D., Canova, S., Colonese, F., Abbate, M.I., Sala, L., Sala, E., Perez Gila, M., Bono, F., Pagni, F., Ceresoli, G.L., D’Aveni, A., Bonomi, M., Grosso, F., De Angelis, A., Ugo, F., Belletti, M., Zucali, P.A., Perrino, M., De Vincenzo, F., Santoro, A., Gelsomino, F., Ardizzoni, A., Pasello, G., Frega, S., Mencoboni, M., Carlucci, L., De Simone, I., D’Incalci, M., Galli, F., Poli, D., Rulli, E., Torri, V., and Cortinovis, D.L.
- Published
- 2022
- Full Text
- View/download PDF
4. PEOPLE (NCT03447678), a first-line phase II pembrolizumab trial, in negative and low PD-L1 advanced NSCLC: clinical outcomes and association with circulating immune biomarkers
- Author
-
Lo Russo, G., Sgambelluri, F., Prelaj, A., Galli, F., Manglaviti, S., Bottiglieri, A., Di Mauro, R.M., Ferrara, R., Galli, G., Signorelli, D., De Toma, A., Occhipinti, M., Brambilla, M., Rulli, E., Triulzi, T., Torelli, T., Agnelli, L., Brich, S., Martinetti, A., Dumitrascu, A.D., Torri, V., Pruneri, G., Fabbri, A., de Braud, F., Anichini, A., Proto, C., Ganzinelli, M., Mortarini, R., and Garassino, M.C.
- Published
- 2022
- Full Text
- View/download PDF
5. Quantification of naturally occurring prebiotic fiber in Italian foods
- Author
-
Fiori, F., Concina, F., Turati, F., Meschiari, M., Gaboardi, G.C., Galli, F., La Vecchia, C., and Parpinel, M.
- Published
- 2022
- Full Text
- View/download PDF
6. Atezolizumab and chemotherapy for advanced or recurrent endometrial cancer (AtTEnd): a randomised, double-blind, placebo-controlled, phase 3 trial
- Author
-
Colombo, N, Biagioli, E, Harano, K, Galli, F, Hudson, E, Antill, Y, Choi, C, Rabaglio, M, Marmé, F, Marth, C, Parma, G, Fariñas-Madrid, L, Nishio, S, Allan, K, Lee, Y, Piovano, E, Pardo, B, Nakagawa, S, Mcqueen, J, Zamagni, C, Manso, L, Takehara, K, Tasca, G, Ferrero, A, Tognon, G, Lissoni, A, Petrella, M, Laudani, M, Rulli, E, Uggeri, S, Barretina Ginesta, M, Zola, P, Casanova, C, Arcangeli, V, Antonuzzo, L, Gadducci, A, Cosio, S, Clamp, A, Persic, M, Mcneish, I, Tookman, L, Redondo Sanchez, A, Baldini, E, Palaia, I, Benedetti Panici, P, Takahashi, N, Lombard, J, Ardizzoia, A, Bologna, A, Herrero Ibáñez, A, Musolino, A, Márquez Vázquez, R, Pietzner, K, Braicu, E, Heinzelmann-Schwarz, V, Powell, M, Yokoyama, Y, Baron-Hay, S, Abeni, C, Martin Lorente, C, Cueva, J, Trillsch, F, Heitz, F, Ataseven, B, Petru, E, Heubner, M, Sadozye, A, Dubey, S, Tazbirkova, A, Tiley, S, Chrystal, K, Kim, S, Fehr, M, Scatchard, K, Anand, A, Taylor, A, Watary, H, Enomoto, T, Yoshihara, K, Selva-Nayagam, S, Karki, B, Harrison, M, Wilkinson, K, Goh, J, Glasgow, A, Chantrill, L, Lee, C, Bertolini, A, Narducci, F, Bellotti, G, Fusco, V, Aebi, S, Del Grande, M, Colombo, I, Tokunaga, H, Shigeta, S, Goss, G, Siow, Z, Steer, C, Lin, H, Colombo N., Biagioli E., Harano K., Galli F., Hudson E., Antill Y., Choi C. H., Rabaglio M., Marmé F., Marth C., Parma G., Fariñas-Madrid L., Nishio S., Allan K., Lee Y. C., Piovano E., Pardo B., Nakagawa S., McQueen J., Zamagni C., Manso L., Takehara K., Tasca G., Ferrero A., Tognon G., Lissoni A. A., Petrella M., Laudani M. E., Rulli E., Uggeri S., Barretina Ginesta M. P., Zola P., Casanova C., Arcangeli V., Antonuzzo L., Gadducci A., Cosio S., Clamp A., Persic M., McNeish I., Tookman L., Redondo Sanchez A., Baldini E., Palaia I., Benedetti Panici P., Takahashi N., Lombard J., Ardizzoia A., Bologna A., Herrero Ibáñez A. M., Musolino A., Márquez Vázquez R., Pietzner K., Braicu E., Heinzelmann-Schwarz V. A., Powell M., Yokoyama Y., Baron-Hay S., Abeni C., Martin Lorente C., Cueva J. F., Trillsch F., Heitz F., Ataseven B., Petru E., Heubner M. L., Sadozye A. H., Dubey S., Tazbirkova A., Tiley S., Chrystal K., Kim S. W., Fehr M., Scatchard K., Anand A., Taylor A., Watary H., Enomoto T., Yoshihara K., Selva-Nayagam S., Karki B., Harrison M., Wilkinson K., Goh J., Glasgow A., Chantrill L., Lee C., Bertolini A., Narducci F., Bellotti G., Fusco V., Aebi S., Del Grande M., Colombo I., Tokunaga H., Shigeta S., Goss G., Siow Z. R., Steer C., Lin H., Colombo, N, Biagioli, E, Harano, K, Galli, F, Hudson, E, Antill, Y, Choi, C, Rabaglio, M, Marmé, F, Marth, C, Parma, G, Fariñas-Madrid, L, Nishio, S, Allan, K, Lee, Y, Piovano, E, Pardo, B, Nakagawa, S, Mcqueen, J, Zamagni, C, Manso, L, Takehara, K, Tasca, G, Ferrero, A, Tognon, G, Lissoni, A, Petrella, M, Laudani, M, Rulli, E, Uggeri, S, Barretina Ginesta, M, Zola, P, Casanova, C, Arcangeli, V, Antonuzzo, L, Gadducci, A, Cosio, S, Clamp, A, Persic, M, Mcneish, I, Tookman, L, Redondo Sanchez, A, Baldini, E, Palaia, I, Benedetti Panici, P, Takahashi, N, Lombard, J, Ardizzoia, A, Bologna, A, Herrero Ibáñez, A, Musolino, A, Márquez Vázquez, R, Pietzner, K, Braicu, E, Heinzelmann-Schwarz, V, Powell, M, Yokoyama, Y, Baron-Hay, S, Abeni, C, Martin Lorente, C, Cueva, J, Trillsch, F, Heitz, F, Ataseven, B, Petru, E, Heubner, M, Sadozye, A, Dubey, S, Tazbirkova, A, Tiley, S, Chrystal, K, Kim, S, Fehr, M, Scatchard, K, Anand, A, Taylor, A, Watary, H, Enomoto, T, Yoshihara, K, Selva-Nayagam, S, Karki, B, Harrison, M, Wilkinson, K, Goh, J, Glasgow, A, Chantrill, L, Lee, C, Bertolini, A, Narducci, F, Bellotti, G, Fusco, V, Aebi, S, Del Grande, M, Colombo, I, Tokunaga, H, Shigeta, S, Goss, G, Siow, Z, Steer, C, Lin, H, Colombo N., Biagioli E., Harano K., Galli F., Hudson E., Antill Y., Choi C. H., Rabaglio M., Marmé F., Marth C., Parma G., Fariñas-Madrid L., Nishio S., Allan K., Lee Y. C., Piovano E., Pardo B., Nakagawa S., McQueen J., Zamagni C., Manso L., Takehara K., Tasca G., Ferrero A., Tognon G., Lissoni A. A., Petrella M., Laudani M. E., Rulli E., Uggeri S., Barretina Ginesta M. P., Zola P., Casanova C., Arcangeli V., Antonuzzo L., Gadducci A., Cosio S., Clamp A., Persic M., McNeish I., Tookman L., Redondo Sanchez A., Baldini E., Palaia I., Benedetti Panici P., Takahashi N., Lombard J., Ardizzoia A., Bologna A., Herrero Ibáñez A. M., Musolino A., Márquez Vázquez R., Pietzner K., Braicu E., Heinzelmann-Schwarz V. A., Powell M., Yokoyama Y., Baron-Hay S., Abeni C., Martin Lorente C., Cueva J. F., Trillsch F., Heitz F., Ataseven B., Petru E., Heubner M. L., Sadozye A. H., Dubey S., Tazbirkova A., Tiley S., Chrystal K., Kim S. W., Fehr M., Scatchard K., Anand A., Taylor A., Watary H., Enomoto T., Yoshihara K., Selva-Nayagam S., Karki B., Harrison M., Wilkinson K., Goh J., Glasgow A., Chantrill L., Lee C., Bertolini A., Narducci F., Bellotti G., Fusco V., Aebi S., Del Grande M., Colombo I., Tokunaga H., Shigeta S., Goss G., Siow Z. R., Steer C., and Lin H.
- Abstract
Background: At the time of AtTEnd trial design, standard treatment for advanced or recurrent endometrial cancer included carboplatin and paclitaxel chemotherapy. This trial assessed whether combining atezolizumab with chemotherapy might improve outcomes in this population. Methods: AtTEnd was a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial done in 89 hospitals in 11 countries across Europe, Australia, New Zealand, and Asia. Enrolled patients were aged 18 years or older, and had advanced or recurrent endometrial carcinoma or carcinosarcoma, an Eastern Cooperative Oncology Group performance status of 0–2, and received no previous systemic chemotherapy for recurrence. Patients were randomly assigned (2:1) using an interactive web response system (block size of six) to either atezolizumab 1200 mg or placebo given intravenously with chemotherapy (carboplatin at area under the curve of 5 or 6 and paclitaxel 175 mg/m2 intravenously on day 1 every 21 days) for 6–8 cycles, then continued until progression. Stratification factors were country, histological subtype, advanced or recurrent status, and mismatch repair (MMR) status. Participants and treating clinicians were masked to group allocation. The hierarchically tested co-primary endpoints were progression-free survival (in patients with MMR-deficient [dMMR] tumours, and in the overall population) and overall survival (in the overall population). Primary analyses were done in the intention-to-treat population, defined as all randomly assigned patients who gave their full consent to participation in the study and data processing. Safety was assessed in all patients included in the intention-to-treat population who received at least one dose of study treatment. Here, we report the primary progression-free survival and the interim overall survival results. This study is ongoing and is registered with ClinicalTrials.gov, NCT03603184. Findings: Between Oct 3, 2018, and Jan 7, 2022, 551 patients were r
- Published
- 2024
7. Acral lentiginous melanoma histotype predicts outcome in clinical stage I-II melanoma patients: an International multicenter study
- Author
-
Mandalà, M., Rutkowski, P., Galli, F., Patuzzo, R., De Giorgi, V., Rulli, E., Gianatti, A., Valeri, B., Merelli, B., Szumera-Ciećkiewicz, A., Massi, D., Maurichi, A., Teterycz, P., and Santinami, M.
- Published
- 2022
- Full Text
- View/download PDF
8. The role of environmental sensitivity, traumatic experiences, defense mechanisms and mental pain on central sensitivity: testing a path analysis model in chronic headache on quality of life.
- Author
-
Nimbi, F.M., Renzi, A., Limoncin, E., and Galli, F.
- Subjects
CHRONIC pain & psychology ,ENVIRONMENTAL health ,DEFENSE mechanisms (Psychology) ,TEMPERAMENT ,RESEARCH funding ,HEADACHE ,CENTRAL nervous system ,PAIN threshold ,PATH analysis (Statistics) ,NOCICEPTIVE pain ,EMOTIONAL trauma ,QUALITY of life ,ADVERSE childhood experiences - Abstract
Central pain sensitivity (CS) is defined as an increased responsiveness of nociceptive neurons in the central nervous system to normal or subthreshold inputs. The main aim of this paper is to investigate if and how specific psychological constructs are related with CS burden in patients with chronic headache (CH). Specifically, research question 1 explores the association of temperament, personality, childhood adversities, defense mechanisms and mental pain with CS burden. Research question 2 aims to test the role of the best predictors of CS burden in affecting the quality of life (QoL) using path analysis. A total of 508 women with CH completed a psycho-diagnostic survey. Results showed that higher levels of low sensory threshold (β = 0.200), bodily threat traumatic experiences (β = 0.156), neurotic defenses (β = 0.109) and mental pain (β = 0.343) emerged as the best predictors of higher CS burden. The model presented demonstrated a satisfactory fit (GFI = 0.984; NFI = 0.966; CFI = 0.979; RMSEA = 0.056 [95% CI 0.028–0.085]) with large and medium effect sizes on physical (−0.654) and psychological QoL (−0.246). The study showed a key role of psychological dimensions in CS burden levels and their relationships with QoL in CH patients. From a clinical perspective, these results suggest the importance of evaluating the level of CS burden during the clinical assessment for chronic pain conditions such as CH, since it may contribute to guide patients to tailored psychological and medical treatments, thereby saving time and costs on diagnostic procedures for chronic pain. [ABSTRACT FROM AUTHOR]
- Published
- 2025
- Full Text
- View/download PDF
9. Holography and thermalization in optical pump-probe spectroscopy
- Author
-
Bagrov, A., Craps, B., Galli, F., Keränen, V., Keski-Vakkuri, E., and Zaanen, J.
- Subjects
High Energy Physics - Theory ,Condensed Matter - Strongly Correlated Electrons ,Condensed Matter - Superconductivity ,Quantum Physics - Abstract
Using holography, we model experiments in which a 2+1D strange metal is pumped by a laser pulse into a highly excited state, after which the time evolution of the optical conductivity is probed. We consider a finite-density state with mildly broken translation invariance and excite it by oscillating electric field pulses. At zero density, the optical conductivity would assume its thermalized value immediately after the pumping has ended. At finite density, pulses with significant DC components give rise to slow exponential relaxation, governed by a vector quasinormal mode. In contrast, for high-frequency pulses the amplitude of the quasinormal mode is strongly suppressed, so that the optical conductivity assumes its thermalized value effectively instantaneously. This surprising prediction may provide a stimulus for taking up the challenge to realize these experiments in the laboratory. Such experiments would test a crucial open question faced by applied holography: Are its predictions artefacts of the large $N$ limit or do they enjoy sufficient UV independence to hold at least qualitatively in real-world systems?, Comment: 7 pages, 4 figures; v2: broader context emphasized, references added
- Published
- 2017
- Full Text
- View/download PDF
10. AB1678-PARE CENTRAL SENSITIVITY AND FIBROMYALGIA: A DISCRIMINATING CONSTRUCT WITHIN DIFFERENT CHRONIC PAIN CONDITIONS
- Author
-
Renzi, A., primary, Mesce, M., additional, Nimbi, F. M., additional, Sarzi-Puttini, P., additional, Bongiovanni, S., additional, and Galli, F., additional
- Published
- 2024
- Full Text
- View/download PDF
11. POS1450-PARE TRAUMATIC EXPERIENCES AND DEFENSIVE MECHANISMS: EXAMINING THE INFLUENCE OF PSYCHOLOGICAL FACTORS IN WOMEN WITH FIBROMYALGIA AND CHRONIC PAIN SYNDROMES IN COMORBIDITY
- Author
-
Mesce, M., primary, Renzi, A., additional, Nimbi, F. M., additional, Sarzi-Puttini, P., additional, Bongiovanni, S., additional, and Galli, F., additional
- Published
- 2024
- Full Text
- View/download PDF
12. Entwinement in discretely gauged theories
- Author
-
Balasubramanian, V., Bernamonti, A., Craps, B., De Jonckheere, T., and Galli, F.
- Subjects
High Energy Physics - Theory - Abstract
We develop the notion of entwinement to characterize the amount of quantum entanglement between internal, discretely gauged degrees of freedom in a quantum field theory. This concept originated in the program of reconstructing spacetime from entanglement in holographic duality. We define entwinement formally in terms of a novel replica method which uses twist operators charged in a representation of the discrete gauge group. In terms of these twist operators we define a non-local, gauge-invariant object whose expectation value computes entwinement in a standard replica limit. We apply our method to the computation of entwinement in symmetric orbifold conformal field theories in 1+1 dimensions, which have an $S_N$ gauging. Such a theory appears in the weak coupling limit of the D1-D5 string theory which is dual to AdS$_3$ at strong coupling. In this context, we show how certain kinds of entwinement measure the lengths, in units of the AdS scale, of non-minimal geodesics present in certain excited states of the system which are gravitationally described as conical defects and the $M=0$ BTZ black hole. The possible types of entwinement that can be computed define a very large new class of quantities characterizing the fine structure of quantum wavefunctions., Comment: 28 pages, 4 figures; v2: clarifications and reference added, minor typos corrected, published version
- Published
- 2016
- Full Text
- View/download PDF
13. Oxaliplatin plus fluoropyrimidines as adjuvant therapy for colon cancer in older patients: A subgroup analysis from the TOSCA trial
- Author
-
Bilancia, D., Rosati, G., Montesarchio, V., Iaffaioli, R.V., Nasti, G., Daniele, B., Zagonel, V., Lonardi, S., Pella, N., Aprile, G., Pasini, F., Marchetti, Roma P., Romiti, A., Ciuffreda, L., Ferrari, D., Foa, P., Zaniboni, A., Labianca, R., Mosconi, S., Sobrero, A., Bidoli, P., Cazzaniga, M., Beretta, G.D., Corsi, D.C., Cortesi, E., Barni, S., Petrelli, F., Allione, P., D'Arco, A.M., Valmadre, G., Piazza, E., Veltri, E., Ramus, G. Vietti, Giustini, L., Tumulo, S., Cascinu, S., Granetto, C., Testore, F., Giordano, M., Moroni, M., Di Seri, M., Nuzzo, A., Angelelli, L., Gori, S., Farina, G., Aglietta, M., Franchi, R., Comandé, M., Giordani, P., Tonini, G., Bucci, E., Ballestrero, A., Benasso, M., Graiff, C., Bravi, S., Caffo, O., Silva, R.R., Frontini, L., Rota, S., Cozzi, L., Cantore, M., Maiello, E., Cinieri, S., Silvestris, N., Romito, S., Gebbia, V., Banzi, M., Santoro, A., Artioli, F., Mattioli, R., Contu, A., Di Costanzo, F., Leonardi, F., Cavanna, L., Passalacqua, R., Amoroso, D., Sozzi, P., D'Amico, M., Amadori, D., Frassineti, L., Turci, D., Ravaioli, A., Pasquini, E., Gambi, A., Faedi, M., Cruciani, G., Bajetta, E., Di Bartolomeo, M., Gianni, L., Ronzoni, M., Ionta, M.T., Massidda, B., Scartozzi, M., Zampino, M.G., Bochicchio, A.M., Ciarlo, A., Di Leo, A., Frustaci, S., Rangoni, G., Arizzoia, A., Pavesi, L., Verusio, C., Pinotti, G., Iop, A., De Placido, S., Carlomagno, C., Adamo, V., Ficorella, C., Natale, D., Greco, E., Rulli, E., Galli, F., Poli, D., Porcu, L., Torri, V., Rosati, Gerardo, Lonardi, Sara, Galli, Fabio, Di Bartolomeo, Maria, Ronzoni, Monica, Zampino, Maria G., Banzi, Maria, Zaniboni, Alberto, Pasini, Felice, Bozzarelli, Silvia, Garattini, Silvio K., Ferrari, Daris, Montesarchio, Vincenzo, Mambrini, Andrea, Ciuffreda, Libero, Galli, Francesca, Pusceddu, Valeria, Carlomagno, Chiara, Bidoli, Paolo, Amoroso, Domenico, Bochicchio, Anna M., Frassineti, Luca, Corsi, Domenico, Bilancia, Domenico, Pastorino, Alessandro, De Stefano, Alfonso, and Labianca, Roberto
- Published
- 2021
- Full Text
- View/download PDF
14. Biodistribution and intracellular localization of hyaluronan and its nanogels. A strategy to target intracellular S. aureus in persistent skin infections
- Author
-
Montanari, E., Mancini, P., Galli, F., Varani, M., Santino, I., Coviello, T., Mosca, L., Matricardi, P., Rancan, F., and Di Meo, C.
- Published
- 2020
- Full Text
- View/download PDF
15. Low pressure conversion of CO2 to methanol over Cu/Zn/Al catalysts. The effect of Mg, Ca and Sr as basic promoters
- Author
-
Previtali, D., Longhi, M., Galli, F., Di Michele, A., Manenti, F., Signoretto, M., Menegazzo, F., and Pirola, C.
- Published
- 2020
- Full Text
- View/download PDF
16. Holographic Quenches and Fermionic Spectral Functions
- Author
-
Callebaut, N., Craps, B., Galli, F., Thompson, D. C., Vanhoof, J., Zaanen, J., and Zhang, Hongbao
- Subjects
High Energy Physics - Theory - Abstract
Using holographic methods we investigate the behaviour of fermionic spectral functions of strongly coupled 2+1 dimensional field theories as both temperature and chemical potential are quenched., Comment: 17 pages, 9 figures; v2: appendix on numerical convergence added to match the published version
- Published
- 2014
- Full Text
- View/download PDF
17. Atomic resolution STM in a cryogen free dilution refrigerator at 15 mK
- Author
-
Haan, A. M. J. den, Wijts, G. H. C. J., Galli, F., Usenko, O., van Baarle, G. J. C., van der Zalm, D. J., and Oosterkamp, T. H.
- Subjects
Physics - Instrumentation and Detectors - Abstract
Pulse tube refrigerators are becoming more common, because they are cost efficient and demand less handling than conventional (wet) refrigerators. However, a downside of a pulse tube system is the vibration level at the cold-head, which is in most designs several micrometers. We implemented vibration isolation techniques which significantly reduced vibration levels at the experiment. These optimizations were necessary for the vibration sensitive Magnetic Resonance Force Microscopy experiments (MRFM) at milli-kelvin temperatures for which the cryostat is intended. With these modifications we show atomic resolution STM on graphite. This is promising for scanning probe microscopy applications at very low temperatures., Comment: 6 pages, 10 figures and 1 video 1st revision: added label a and b to figures 2 and 3 typo at page 5 at the end of section 4 (Results): replaced 10^-10 m/sqrt(Hz) to 10^-12 m/sqrt(Hz) (contact haan@physics.leidenuniv.nl for the calculation)
- Published
- 2013
- Full Text
- View/download PDF
18. Inhomogeneous holographic thermalization
- Author
-
Balasubramanian, V., Bernamonti, A., de Boer, J., Craps, B., Franti, L., Galli, F., Keski-Vakkuri, E., Müller, B., and Schäfer, A.
- Subjects
High Energy Physics - Theory ,High Energy Physics - Phenomenology ,Nuclear Theory - Abstract
The sudden injection of energy in a strongly coupled conformal field theory and its subsequent thermalization can be holographically modeled by a shell falling into anti-de Sitter space and forming a black brane. For a homogeneous shell, Bhattacharyya and Minwalla were able to study this process analytically using a weak field approximation. Motivated by event-by-event fluctuations in heavy ion collisions, we include inhomogeneities in this model, obtaining analytic results in a long wavelength expansion. In the early-time window in which our approximations can be trusted, the resulting evolution matches well with that of a simple free streaming model. Near the end of this time window, we find that the stress tensor approaches that of second-order viscous hydrodynamics. We comment on possible lessons for heavy ion phenomenology., Comment: 53 pages, 10 figures; v2: references added
- Published
- 2013
- Full Text
- View/download PDF
19. Inhomogeneous Thermalization in Strongly Coupled Field Theories
- Author
-
Balasubramanian, V., Bernamonti, A., de Boer, J., Craps, B., Franti, L., Galli, F., Keski-Vakkuri, E., Müller, B., and Schäfer, A.
- Subjects
High Energy Physics - Theory ,High Energy Physics - Phenomenology ,Nuclear Theory - Abstract
To describe theoretically the creation and evolution of the quark-gluon plasma, one typically employs three ingredients: a model for the initial state, non-hydrodynamic early time evolution, and hydrodynamics. In this paper we study the non-hydrodynamic early time evolution using the AdS/CFT correspondence in the presence of inhomogeneities. We find that the AdS description of the early time evolution is well-matched by free streaming. Near the end of the early time interval where our analytic computations are reliable, the stress tensor agrees with the second order hydrodynamic stress tensor computed from the local energy density and fluid velocity. Our techniques may also be useful for the study of far-from-equilibrium strongly coupled systems in other areas of physics., Comment: 5 pages, 3 figures; v2: minor clarifications and reference added
- Published
- 2013
- Full Text
- View/download PDF
20. pH-responsive poly(lactide-co-glycolide) nanoparticles containing near-infrared dye for visualization and hyaluronic acid for treatment of osteoarthritis
- Author
-
Zerrillo, L., Que, I., Vepris, O., Morgado, L.N., Chan, A., Bierau, K., Li, Y., Galli, F., Bos, E., Censi, R., Di Martino, P., van Osch, G.J.V.M., and Cruz, L.J.
- Published
- 2019
- Full Text
- View/download PDF
21. An ultrasound-assisted photocatalytic treatment to remove an herbicidal pollutant from wastewaters
- Author
-
Schieppati, D., Galli, F., Peyot, M.-L., Yargeau, V., Bianchi, C.L., and Boffito, D.C.
- Published
- 2019
- Full Text
- View/download PDF
22. Micro-TiO2 coated glass surfaces safely abate drugs in surface water
- Author
-
Cerrato, G., Bianchi, C.L., Galli, F., Pirola, C., Morandi, S., and Capucci, V.
- Published
- 2019
- Full Text
- View/download PDF
23. Thermalization of mutual and tripartite information in strongly coupled two dimensional conformal field theories
- Author
-
Balasubramanian, V., Bernamonti, A., Copland, N., Craps, B., and Galli, F.
- Subjects
High Energy Physics - Theory - Abstract
The mutual and tripartite information between pairs and triples of disjoint regions in a quantum field theory are sensitive probes of the spread of correlations in an equilibrating system. We compute these quantities in strongly coupled two-dimensional conformal field theories with a gravity dual following the homogenous deposition of energy. The injected energy is modeled in anti-de Sitter space as an infalling shell, and the information shared by disjoint intervals is computed in terms of geodesic lengths in this background. For given widths and separation of the intervals, the mutual information typically starts at its vacuum value, then increases in time to reach a maximum, and then declines to the value at thermal equilibrium. A simple causality argument qualitatively explains this behavior. The tripartite information is generically non-zero and time-dependent throughout the process. This contrasts with (but does not contradict) the time-independent tripartite information one finds after a two-dimensional quantum quench in the limit of large time and distance scales compared to the initial inverse mass gap., Comment: 12 pages, 8 figures, v2: cosmetic changes to match the published version
- Published
- 2011
- Full Text
- View/download PDF
24. Potency assays and biomarkers for cell-based advanced therapy medicinal products
- Author
-
Capelli, C, Cuofano, C, Pavoni, C, Frigerio, S, Lisini, D, Nava, S, Quaroni, M, Colombo, V, Galli, F, Bezukladova, S, Panina-Bordignon, P, Gaipa, G, Comoli, P, Cossu, G, Martino, G, Biondi, A, Introna, M, Golay, J, Capelli C., Cuofano C., Pavoni C., Frigerio S., Lisini D., Nava S., Quaroni M., Colombo V., Galli F., Bezukladova S., Panina-Bordignon P., Gaipa G., Comoli P., Cossu G., Martino G., Biondi A., Introna M., Golay J., Capelli, C, Cuofano, C, Pavoni, C, Frigerio, S, Lisini, D, Nava, S, Quaroni, M, Colombo, V, Galli, F, Bezukladova, S, Panina-Bordignon, P, Gaipa, G, Comoli, P, Cossu, G, Martino, G, Biondi, A, Introna, M, Golay, J, Capelli C., Cuofano C., Pavoni C., Frigerio S., Lisini D., Nava S., Quaroni M., Colombo V., Galli F., Bezukladova S., Panina-Bordignon P., Gaipa G., Comoli P., Cossu G., Martino G., Biondi A., Introna M., and Golay J.
- Abstract
Advanced Therapy Medicinal Products (ATMPs) based on somatic cells expanded in vitro, with or without genetic modification, is a rapidly growing area of drug development, even more so following the marketing approval of several such products. ATMPs are produced according to Good Manufacturing Practice (GMP) in authorized laboratories. Potency assays are a fundamental aspect of the quality control of the end cell products and ideally could become useful biomarkers of efficacy in vivo. Here we summarize the state of the art with regard to potency assays used for the assessment of the quality of the major ATMPs used clinic settings. We also review the data available on biomarkers that may substitute more complex functional potency tests and predict the efficacy in vivo of these cell-based drugs.
- Published
- 2023
25. Correlations between the morphology and the electronic structure at the surface of thin film manganites, investigated with STM
- Author
-
Kelly, S., Galli, F., Komissarov, I., and Aarts, J.
- Subjects
Condensed Matter - Strongly Correlated Electrons - Abstract
Thin-film colossal magnetoresistance manganites such as La$_{0.67}$Ca$_{0.33}$MnO$_{3}$ (LCMO) have now been intensely studied for more than a decade, but the issue of possible nanoscale electronic phase separation is not fully solved. Scanning Tunneling Microscopy / Spectroscopy (STS) has been pivotal in studying phase separation, but is hindered by being surface- rather than bulk-sensitive. For our sputtered LCMO films the data indicates a strong correlation between surface morphology and signatures of phase separation; rough films show phase separation while atomically flat films are electronically homogeneous but have a more or less inactive surface layer. Regardless of surface morphology, the film bulk is electronically and magnetically active. Many of the reported conclusions about electronic inhomogeneities measured by STS have been confused by this issue. We study both strained and unstrained films and find no correlation between substrate-induced strain and either electronic phase separation or dead layers.
- Published
- 2009
26. Targeting glutathione S-transferase P and its interactome with selenium compounds in cancer therapy
- Author
-
Bartolini, D., Torquato, P., Piroddi, M., and Galli, F.
- Published
- 2019
- Full Text
- View/download PDF
27. Lack of Efficacy: When Opioids Do Not Achieve Analgesia from the Beginning of Treatment in Cancer Patients
- Author
-
Corli O, Damia G, Galli F, Verrastro C, and Broggini M
- Subjects
opioids ,lack of analgesia ,cancer pain ,non-responders ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Oscar Corli,1 Giovanna Damia,2 Francesca Galli,3 Carmen Verrastro,4 Massimo Broggini2 1Unit of Pain and Palliative Care Research, Laboratory of Methodology for Clinical Research, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy; 2Laboratory of Molecular Pharmacology, Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy; 3Laboratory of Methodology for Clinical Research, Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy; 4Day Hospital of Rheumatology, ASST Gaetano Pini CTO, Milan, ItalyCorrespondence: Oscar CorliUnit of Pain and Palliative Care Research, Laboratory of Methodology for Clinical Research, Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via G. La Masa 19, Milan 20156, ItalyTel +39 02390141Fax +39 023546277Email oscar.corli@marionegri.itIntroduction: Opioids are often used to relieve moderate to severe pain, but their analgesic response may vary. We focused on the absolute lack of analgesic response immediately after beginning opioid treatment, quantifying the proportion of patients with unchanged or worse pain on day 3 (defined as early non-responders (ENRs)) and day 7.Methods: This is a post-hoc analysis from a randomized controlled trial involving 498 cancer patients with pain, starting to receive WHO step III opioids. On days 1, 3 and 7 pain intensity (PI) was measured.Results: On day 3, 68 (13.7%) patients were ENRs, 53 no change and 15 greater PI compared to baseline. The relationships between pain and clinical characteristics showed no significant differences between ENRs and Early responders (ERs), except for PI at baseline, which was significantly lower in ENRs. ENRs on day 3 were re-assessed on day 7 to explore the patterns of analgesic response: 31.7% of patients remained NRs, 48.3% had become responders, and 20.0% were poor responders. Adverse drug reactions were similar in ERs and ENRs at each visit.Discussion: The complete lack of early response to opioids in cancer patients is clinically important and more frequent than expected. Better definition of the mechanism will allow better pain management in cancer and non-cancer patients.Keywords: opioids, lack of analgesia, cancer pain, non-responders
- Published
- 2019
28. Depth dependent spin dynamics of canonical spin glass films: A low-energy muon spin rotation study
- Author
-
Morenzoni, E., Luetkens, H., Prokscha, T., Suter, A., Vongtragool, S., Galli, F., Hesselberth, M. B. S., Garifianov, N., and Khasanov, R.
- Subjects
Condensed Matter - Disordered Systems and Neural Networks - Abstract
We have performed depth dependent muon spin rotation/relaxation studies of the dynamics of single layer films of {\it Au}Fe and {\it Cu}Mn spin glasses as a function of thickness and of its behavior as a function of distance from the vacuum interface (5-70 nm). A significant reduction in the muon spin relaxation rate as a function of temperature with respect to the bulk material is observed when the muons are stopped near (5-10 nm) the surface of the sample. A similar reduction is observed for the whole sample if the thickness is reduced to e.g. 20 nm and less. This reflects an increased impurity spin dynamics (incomplete freezing) close to the surface although the freezing temperature is only modestly affected by the dimensional reduction.
- Published
- 2007
- Full Text
- View/download PDF
29. Vortex relaxation and coupling in superconducting heterostructures studied by STM
- Author
-
van Baarle, G. J. C., Galli, F., Kes, P. H., and Aarts, J.
- Subjects
Condensed Matter - Superconductivity - Abstract
In a sandwich consisting of two superconducting films, one weakly pinning and one strongly pinning, the vortex positions in both films are determined by the strongly pinning material and the vortex lattice is disordered in both films. We used (strongly pinning) NbN and (weakly pinning) MoGe and studied, by directly imaging the vortex core positions with a scanning tunnelling microscope, how this disorder is restored with increasing thickness of MoGe layer or when the interface is made insulating. For clean interfaces we find that the first reordering of the vortex lattice is found at a layer thickness wich is compatible with the first bending mode of the vortex lines. Making the interface insulating we find that order is restored quickly. We argue that this is can be understood from the competition between the Josephson force working on the vortex segments on the one hand, and the elastic restoring forces inside the weakly pinning layer on the other hand., Comment: 7 pages, 9 figures
- Published
- 2007
30. How to compare global and local pollutant emissions
- Author
-
Dinkelacker, Friedrich, Galli, F., Bargende, Michael, editor, Reuss, Hans-Christian, editor, and Wiedemann, Jochen, editor
- Published
- 2018
- Full Text
- View/download PDF
31. Production and application of O2 enriched air produced by fresh and salt water desorption in chemical plants
- Author
-
Galli, F., Previtali, D., Bozzano, G., Bianchi, C.L., Manenti, F., and Pirola, C.
- Published
- 2018
- Full Text
- View/download PDF
32. Magnetic field and pressure effects on charge density wave, superconducting, and magnetic states in Lu$_5$Ir$_4$Si$_{10}$ and Er$_5$Ir$_4$Si$_{10}$
- Author
-
Jung, M. H., Kim, H. C., Galli, F., and Mydosh, J. A.
- Subjects
Condensed Matter - Strongly Correlated Electrons ,Condensed Matter - Superconductivity - Abstract
We have studied the charge-density-wave (CDW) state for the superconducting Lu$_5$Ir$_4$Si$_{10}$ and the antiferromagnetic Er$_5$Ir$_4$Si$_{10}$ as variables of temperature, magnetic field, and hydrostatic pressure. For Lu$_5$Ir$_4$Si$_{10}$, the application of pressure strongly suppresses the CDW phase but weakly enhances the superconducting phase. For Er$_5$Ir$_4$Si$_{10}$, the incommensurate CDW state is pressure independent and the commensurate CDW state strongly depends on the pressure, whereas the antiferromagnetic ordering is slightly depressed by applying pressure. In addition, Er$_5$Ir$_4$Si$_{10}$ shows negative magnetoresistance at low temperatures, compared with the positive magnetoresistance of Lu$_5$Ir$_4$Si$_{10}$., Comment: 12 pages, including 6 figures
- Published
- 2003
- Full Text
- View/download PDF
33. Opioid switching and variability in response in pain cancer patients
- Author
-
Corli, O., Roberto, A., Corsi, N., Galli, F., and Pizzuto, M.
- Published
- 2019
- Full Text
- View/download PDF
34. Spin dynamics in hole-doped two-dimensional S=1/2 Heisenberg antiferromagnets: ^{63}Cu NQR relaxation in La_{2-x}Sr_xCuO_4 for $x\leq 0.04$
- Author
-
Carretta, P., Tedoldi, F., Rigamonti, A., Galli, F., Borsa, F., Cho, J. H., and Johnston, D. C.
- Subjects
Condensed Matter - Strongly Correlated Electrons ,Condensed Matter - Superconductivity - Abstract
The effects on the correlated Cu^{2+} S = 1/2 spin dynamics in the paramagnetic phase of La_{2-x}Sr_xCuO_4 (for $x \lesssim 0.04$) due to the injection of holes are studied by means of ^{63}Cu NQR spin-lattice relaxation time T_1 measurements. The results are discussed in the framework of the connection between T_1 and the in-plane magnetic correlation length $\xi_{2D}(x,T)$. It is found that at high temperatures the system remains in the renormalized classical regime, with a spin stiffness constant $\rho_s(x)$ reduced by small doping to an extent larger than the one due to Zn doping. For $x\gtrsim 0.02$ the effect of doping on $\rho_s(x)$ appears to level off. The values for $\rho_s(x)$ derived from T_1 for $T\gtrsim 500$ K are much larger than the ones estimated from the temperature behavior of sublattice magnetization in the ordered phase ($T\leq T_N$). It is argued that these features are consistent with the hypothesis of formation of stripes of microsegregated holes., Comment: 10 pages, 3 figures
- Published
- 1999
- Full Text
- View/download PDF
35. CYP4F2 repression and a modified alpha-tocopherol (vitamin E) metabolism are two independent consequences of ethanol toxicity in human hepatocytes
- Author
-
Russo, A., Bartolini, D., Torquato, P., Giusepponi, D., Barola, C., Galarini, R., Birringer, M., Lorkowski, S., and Galli, F.
- Published
- 2017
- Full Text
- View/download PDF
36. Chapter 7 Visual Perception in Dante's Commedia According to the Early Commentaries (1320–1400)
- Author
-
Galli, Francesca
- Subjects
Medieval Optics,Dante Alighieri,Trecento Commentaries on Commedia,Light,perspectiva ,thema EDItEUR::N History and Archaeology::NH History::NHD European history ,thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDH Philosophical traditions and schools of thought::QDHF Medieval Western philosophy ,thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDX History of science - Abstract
Dante’s Visions: Crossing Sights on Natural Philosophy, Theory of Vision, and Medicine in the Divine Comedy and Beyond offers a fascinating insight into Dante’s engagement with the science of his time, particularly with visual perception and neurological disorders. The relationship between the soul and the body and the bond between human beings and their natural environment were significant areas of interest in the medieval world. In Dante’s Divine Comedy, as well as in his Vita Nuova and Convivio, these connections are enhanced to the fullest, expressing feelings and sensations, pain and ecstasy, and physical and spiritual passions under exceptional psychological and environmental stimuli. Based on the research of a multidisciplinary group of scholars – including experts in Dante, the culture and history of medieval literature and philosophy, historians of science, neuroscientists, and specialists in vision and visual illusions – this book explores the poet’s psychophysical descriptions of sense perception, the theory of vision, optical illusions and deceptions of sight, neurological phenomena, and the anatomy and physiology of the human nervous system. It highlights the Aristotelian sources of his scientific culture and the influence of the Arabic sciences on their dissemination in the Western world. In addition to illustrating the cultural background of a poetic genius, with specific reference to the rich scientific reflections in Italy at Dante’s time, this book brings out the many opportunities for future research at the intersection of science and literature in the past.
- Published
- 2025
- Full Text
- View/download PDF
37. A comparison between the administration of oral prolonged-release oxycodone-naloxone and transdermal fentanyl in patients with moderate-to-severe cancer pain: a propensity score analysis
- Author
-
Roberto A, Greco MT, Legramandi L, Galli F, Galli M, and Corli O
- Subjects
cancer pain ,oxycodone-naloxone ,transdermal fentanyl ,propensity score ,analgesic efficacy ,constipation. ,Medicine (General) ,R5-920 - Abstract
A Roberto,1 MT Greco,2 L Legramandi,3 F Galli,3 M Galli,4 O Corli1 1Pain and Palliative Care Research Unit, Oncology Department, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy, 2Department of Clinical Sciences and Community, University of Milan, Milan, Italy, 3Methodology for Clinical Research Laboratory, Oncology Department, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy, 4Scientific Medical Communication srl, Novara, Italy Background: Opioids are the most important pharmacological treatment for moderate-to-severe cancer pain, but side effects limit their use. Transdermal fentanyl (TDF) and oral prolonged-release oxycodone-naloxone (OXN-PR) are effective in controlling chronic pain, with less constipation compared to other opioids. However, TDF and OXN-PR have never been directly compared.Patients and methods: Cancer patients with moderate-to-severe chronic pain were consecutively enrolled in two prospective 28-day trials, received either TDF or OXN-PR, and were assessed at baseline and after 7, 14, 21, and 28 days. The primary endpoint was 28-day analgesic response rate (average pain intensity decrease ≥30% from baseline). Other outcome measures included opioid daily dose changes over time; need for adjuvant analgesics; number of switches; premature discontinuation; presence and severity of constipation; and other adverse drug reactions. To compare the efficacy and the safety of TDF and OXN-PR, we used the propensity score analysis to adjust for heterogeneity between the two patient groups.Results: Three hundred ten out of 336 patients originally treated (119 TDF and 191 OXN-PR) were included in the comparative analysis. The amount of responders was comparable after TDF (75.3%) and OXN-PR administration (82.9%, not significant [NS]). The final opioid daily dose expressed as morphine equivalent was 113.6 mg for TDF and 44.5 mg for OXN-PR (p5% was less common after OXN-PR (19.3%) than after TDS administration (37.9%, p
- Published
- 2017
38. Phase III trial comparing 3–6 months of adjuvant FOLFOX4/XELOX in stage II–III colon cancer: safety and compliance in the TOSCA trial
- Author
-
Bilancia, D., Rosati, G., Montesarchio, V., Iaffaioli, R.V., Nasti, G., Daniele, B., Zagonel, V., Lonardi, S., Pella, N., Aprile, G., Pasini, F., Marchetti, P., Romiti, A., Ciuffreda, L., Ferrari, D., Foa, P., Zaniboni, A., Labianca, R., Mosconi, S., Sobrero, A., Bidoli, P., Cazzaniga, M., Beretta, G.D., Corsi, D.C., Cortesi, E., Barni, S., Petrelli, F., Cantore, M., Maiello, E., Cinieri, S., Banzi, M., Santoro, A., Artioli, F., Mattioli, R., Amoroso, D., Amadori, D., Frassineti, L., Turci, D., Ravaioli, A., Bajetta, E., Di Bartolomeo, M., Gianni, L., Ronzoni, M., Ionta, M.T., Massidda, B., Scartozzi, M., Zampino, M.G., Bochicchio, A., Ciarlo, A., Di Leo, A., De Placido, S., Carlomagno, C., Adamo, V., Natale, D., Rulli, E., Galli, F., Poli, D., Torri, V., and Rimassa, L.
- Published
- 2016
- Full Text
- View/download PDF
39. Flame Spray Pyrolysis as fine preparation technique for stable Co and Co/Ru based catalysts for FT process
- Author
-
Comazzi, A., Pirola, C., Di Michele, A., Compagnoni, M., Galli, F., Rossetti, I., Manenti, F., and Bianchi, C.L.
- Published
- 2016
- Full Text
- View/download PDF
40. Are strong opioids equally effective and safe in the treatment of chronic cancer pain? A multicenter randomized phase IV ‘real life’ trial on the variability of response to opioids
- Author
-
Monfredo, M., Mistretta, R., di Salemi, P.O., Zecca, E., Cartoni, C., Brunetti, G.A., Tassinari, D., Drudi, F., Rizzi, F., Pizzuto, M., Formaglio, F., Luzi, M., Narducci, F., Boscolo, G., Mangiapia, M., Artioli, F., Lazzari, M., Dauri, M., Diodati, M., Cupaiolo, A., Mameli, S., Preti, P., Ferrari, P., Vasini, G., Roy, M.T., Piva, L., Nardi, L.F., Montanari, L., Reina, V., Fusco, F., Orsi, L., Molinari, E., Corli, O., Floriani, I., Roberto, A., Montanari, M., Galli, F., Greco, M.T., Caraceni, A., Kaasa, S., Dragani, T.A., Azzarello, G., Luzzani, M., Cavanna, L., Bandieri, E., Gamucci, T., Lipari, G., Di Gregorio, R., Valenti, D., Reale, C., Pavesi, L., Iorno, V., Crispino, C., Pacchioni, M., and Apolone, G.
- Published
- 2016
- Full Text
- View/download PDF
41. Open versus laparoscopic gastrectomy for advanced gastric cancer: a propensity score matching analysis of survival in a western population—on behalf of the Italian Research Group for Gastric Cancer
- Author
-
Lombardi, P, Bernasconi, D, Baiocchi, G, Berselli, M, Biondi, A, Castoro, C, Catarci, M, Degiuli, M, Fumagalli Romario, U, Giacopuzzi, S, Marchesi, F, Marrelli, D, Mazzola, M, Molfino, S, Olmi, S, Rausei, S, Rosa, F, Rosati, R, Roviello, F, Santi, S, Solaini, L, Staderini, F, Vigano, J, Ferrari, G, Agnes, A, Alfieri, S, Alloggio, M, Bencivenga, M, Benedetti, M, Bottari, A, Cianchi, F, Cocozza, E, Dalmonte, G, De Martini, P, De Pascale, S, Desio, M, Emiliani, G, Ercolani, G, Galli, F, Garosio, I, Giani, A, Gualtierotti, M, Marano, L, Morgagni, P, Peri, A, Puccetti, F, Reddavid, R, Uccelli, M, Lombardi P. M., Bernasconi D., Baiocchi G. L., Berselli M., Biondi A., Castoro C., Catarci M., Degiuli M., Fumagalli Romario U., Giacopuzzi S., Marchesi F., Marrelli D., Mazzola M., Molfino S., Olmi S., Rausei S., Rosa F., Rosati R., Roviello F., Santi S., Solaini L., Staderini F., Vigano J., Ferrari G., Agnes A., Alfieri S., Alloggio M., Bencivenga M., Benedetti M., Bottari A., Cianchi F., Cocozza E., Dalmonte G., De Martini P., De Pascale S., Desio M., Emiliani G., Ercolani G., Galli F., Garosio I., Giani A., Gualtierotti M., Marano L., Morgagni P., Peri A., Puccetti F., Reddavid R., Uccelli M., Lombardi, P, Bernasconi, D, Baiocchi, G, Berselli, M, Biondi, A, Castoro, C, Catarci, M, Degiuli, M, Fumagalli Romario, U, Giacopuzzi, S, Marchesi, F, Marrelli, D, Mazzola, M, Molfino, S, Olmi, S, Rausei, S, Rosa, F, Rosati, R, Roviello, F, Santi, S, Solaini, L, Staderini, F, Vigano, J, Ferrari, G, Agnes, A, Alfieri, S, Alloggio, M, Bencivenga, M, Benedetti, M, Bottari, A, Cianchi, F, Cocozza, E, Dalmonte, G, De Martini, P, De Pascale, S, Desio, M, Emiliani, G, Ercolani, G, Galli, F, Garosio, I, Giani, A, Gualtierotti, M, Marano, L, Morgagni, P, Peri, A, Puccetti, F, Reddavid, R, Uccelli, M, Lombardi P. M., Bernasconi D., Baiocchi G. L., Berselli M., Biondi A., Castoro C., Catarci M., Degiuli M., Fumagalli Romario U., Giacopuzzi S., Marchesi F., Marrelli D., Mazzola M., Molfino S., Olmi S., Rausei S., Rosa F., Rosati R., Roviello F., Santi S., Solaini L., Staderini F., Vigano J., Ferrari G., Agnes A., Alfieri S., Alloggio M., Bencivenga M., Benedetti M., Bottari A., Cianchi F., Cocozza E., Dalmonte G., De Martini P., De Pascale S., Desio M., Emiliani G., Ercolani G., Galli F., Garosio I., Giani A., Gualtierotti M., Marano L., Morgagni P., Peri A., Puccetti F., Reddavid R., and Uccelli M.
- Abstract
Background: Oncologic outcomes after laparoscopic gastrectomy for advanced gastric cancer in the West have been poorly investigated. The aim of the present study was to compare survival outcomes in patients undergoing curative-intent laparoscopic and open gastrectomy for advanced gastric cancer in several centres belonging to the Italian Research Group for Gastric Cancer. Methods: Data of patients operated between 2015 and 2018 were retrospectively analysed. Propensity Score Matching was performed to balance baseline characteristics of patients undergoing laparoscopic and open gastrectomy. The primary endpoint was 3-year overall survival. Secondary endpoints were 3-year disease-free survival and short-term outcomes. Multivariable regression analyses for survival were conducted. Results: Data were retrieved from 20 centres. Of the 717 patients included, 438 patients were correctly matched, 219 per group. The 3-year overall survival was 73.6% and 68.7% in the laparoscopic and open group, respectively (p = 0.40). When compared with open gastrectomy, laparoscopic gastrectomy showed comparable 3-year disease-free survival (62.8%, vs 58.9%, p = 0.40), higher rate of return to intended oncologic treatment (56.9% vs 40.2%, p = 0.001), similar 30-day morbidity/mortality. Prognostic factors for survival were ASA Score ≥ 3, age-adjusted Charlson Comorbidity Index ≥ 5, lymph node ratio ≥ 0.15, p/ypTNM Stage III and return to intended oncologic treatment. Conclusions: Laparoscopic gastrectomy for advanced gastric cancer offers similar rates of survival when compared to open gastrectomy, with higher rates of return to intended oncologic treatment. ASA score, age-adjusted Charlson Comorbidity Index, lymph node ratio, return to intended oncologic treatment and p/ypTNM Stage, but not surgical approach, are prognostic factors for survival.
- Published
- 2022
42. Final results of DIADEM, a phase II study to investigate the efficacy and safety of durvalumab in advanced pretreated malignant pleural mesothelioma
- Author
-
Canova, S, Ceresoli, G, Grosso, F, Zucali, P, Gelsomino, F, Pasello, G, Mencoboni, M, Rulli, E, Galli, F, De Simone, I, Carlucci, L, De Angelis, A, Belletti, M, Bonomi, M, D'Aveni, A, Perrino, M, Bono, F, Cortinovis, D, Colonese, F, Abbate, M, Sala, L, Sala, E, Perez Gila, M, Pagni, F, Ugo, F, De Vincenzo, F, Santoro, A, Ardizzoni, A, Frega, S, D'Incalci, M, Poli, D, Torri, V, Canova S., Ceresoli G. L., Grosso F., Zucali P. A., Gelsomino F., Pasello G., Mencoboni M., Rulli E., Galli F., De Simone I., Carlucci L., De Angelis A., Belletti M., Bonomi M., D'Aveni A., Perrino M., Bono F., Cortinovis D. L., Cortinovis D., Colonese F., Abbate M. I., Sala L., Sala E., Perez Gila M., Pagni F., Ugo F., De Vincenzo F., Santoro A., Ardizzoni A., Frega S., D'Incalci M., Poli D., Torri V., Canova, S, Ceresoli, G, Grosso, F, Zucali, P, Gelsomino, F, Pasello, G, Mencoboni, M, Rulli, E, Galli, F, De Simone, I, Carlucci, L, De Angelis, A, Belletti, M, Bonomi, M, D'Aveni, A, Perrino, M, Bono, F, Cortinovis, D, Colonese, F, Abbate, M, Sala, L, Sala, E, Perez Gila, M, Pagni, F, Ugo, F, De Vincenzo, F, Santoro, A, Ardizzoni, A, Frega, S, D'Incalci, M, Poli, D, Torri, V, Canova S., Ceresoli G. L., Grosso F., Zucali P. A., Gelsomino F., Pasello G., Mencoboni M., Rulli E., Galli F., De Simone I., Carlucci L., De Angelis A., Belletti M., Bonomi M., D'Aveni A., Perrino M., Bono F., Cortinovis D. L., Cortinovis D., Colonese F., Abbate M. I., Sala L., Sala E., Perez Gila M., Pagni F., Ugo F., De Vincenzo F., Santoro A., Ardizzoni A., Frega S., D'Incalci M., Poli D., and Torri V.
- Abstract
Background: Malignant pleural mesothelioma (MPM) is a cancer with a high mortality rate and few therapeutic options. After platinum–pemetrexed combination, no further promising drug seems to be effective. Immune checkpoint inhibitors may have some activity in pretreated patients and no data are available in this population about durvalumab. Materials and methods: DIADEM was a multicenter, open-label, single-arm, phase II trial aimed at evaluating the efficacy and safety of durvalumab. Patients with locally advanced/metastatic MPM who progressed after platinum–pemetrexed chemotherapy were enrolled to receive durvalumab (1500 mg, intravenously Q4W) for 12 months or until evidence of disease progression or unacceptable toxicity. The primary endpoint was the proportion of patients alive and free from progression at 16 weeks (PFS16wks) calculated from treatment initiation. Secondary endpoints were progression-free survival, overall survival, overall response rate, and safety. Results: Sixty-nine patients with a median age of 69 years (range 44-82 years) were enrolled; 62 patients (89.9%) had epithelioid histotype. As first-line treatment, all patients received platinum derivatives–pemetrexed combination (60.9% with carboplatin and 39.1% with cisplatin). As of March 2021, the median follow-up was 9.2 months (interquartile range 5.2-11.1 months). Six patients (8.7%) completed the 12-month treatment; 60 patients discontinued, of whom 42 for progressive disease, and 4 died. Seventeen patients (28.3%; 95% confidence interval 17.5% to 41.4%) were alive or free from progression at 16 weeks. Eleven patients (18.6%) had a grade 3 or 4 treatment-related adverse event (AE), and one (1.4%) had a grade ≥3 immune-related, treatment-related AE. There was one drug-related death. Conclusion: Durvalumab alone in pretreated non-selected MPM did not reach a meaningful clinical activity, showing any new major safety issue signals.
- Published
- 2022
43. Study of the photochemical transformation of 2-ethylhexyl 4-(dimethylamino)benzoate (OD-PABA) under conditions relevant to surface waters
- Author
-
Calza, P., Vione, D., Galli, F., Fabbri, D., Dal Bello, F., and Medana, C.
- Published
- 2016
- Full Text
- View/download PDF
44. Understanding the food environment: the role of practice theory and policy implications.
- Author
-
Mattioni, D., primary, Galli, F., additional, and Brunori, G., additional
- Published
- 2018
- Full Text
- View/download PDF
45. Mesoangioblasts at 20: From the embryonic aorta to the patient bed
- Author
-
Cossu, G, Tonlorenzi, R, Brunelli, S, Sampaolesi, M, Messina, G, Azzoni, E, Benedetti, S, Biressi, S, Bonfanti, C, Bragg, L, Camps, J, Cappellari, O, Cassano, M, Ciceri, F, Coletta, M, Covarello, D, Crippa, S, Cusella-De Angelis, M, De Angelis, L, Dellavalle, A, Diaz-Manera, J, Galli, D, Galli, F, Gargioli, C, Gerli, M, Giacomazzi, G, Galvez, B, Hoshiya, H, Guttinger, M, Innocenzi, A, Minasi, M, Perani, L, Previtali, S, Quattrocelli, M, Ragazzi, M, Roostalu, U, Rossi, G, Scardigli, R, Sirabella, D, Tedesco, F, Torrente, Y, Ugarte, G, Cossu, Giulio, Tonlorenzi, Rossana, Brunelli, Silvia, Sampaolesi, Maurilio, Messina, Graziella, Azzoni, Emanuele, Benedetti, Sara, Biressi, Stefano, Bonfanti, Chiara, Bragg, Laricia, Camps, Jordi, Cappellari, Ornella, Cassano, Marco, Ciceri, Fabio, Coletta, Marcello, Covarello, Diego, Crippa, Stefania, Cusella-De Angelis, M Gabriella, De Angelis, Luciana, Dellavalle, Arianna, Diaz-Manera, Jordi, Galli, Daniela, Galli, Francesco, Gargioli, Cesare, Gerli, Mattia F M, Giacomazzi, Giorgia, Galvez, Beatriz G, Hoshiya, Hidetoshi, Guttinger, Maria, Innocenzi, Anna, Minasi, M Giulia, Perani, Laura, Previtali, Stefano C, Quattrocelli, Mattia, Ragazzi, Martina, Roostalu, Urmas, Rossi, Giuliana, Scardigli, Raffaella, Sirabella, Dario, Tedesco, Francesco Saverio, Torrente, Yvan, Ugarte, Gonzalo, Cossu, G, Tonlorenzi, R, Brunelli, S, Sampaolesi, M, Messina, G, Azzoni, E, Benedetti, S, Biressi, S, Bonfanti, C, Bragg, L, Camps, J, Cappellari, O, Cassano, M, Ciceri, F, Coletta, M, Covarello, D, Crippa, S, Cusella-De Angelis, M, De Angelis, L, Dellavalle, A, Diaz-Manera, J, Galli, D, Galli, F, Gargioli, C, Gerli, M, Giacomazzi, G, Galvez, B, Hoshiya, H, Guttinger, M, Innocenzi, A, Minasi, M, Perani, L, Previtali, S, Quattrocelli, M, Ragazzi, M, Roostalu, U, Rossi, G, Scardigli, R, Sirabella, D, Tedesco, F, Torrente, Y, Ugarte, G, Cossu, Giulio, Tonlorenzi, Rossana, Brunelli, Silvia, Sampaolesi, Maurilio, Messina, Graziella, Azzoni, Emanuele, Benedetti, Sara, Biressi, Stefano, Bonfanti, Chiara, Bragg, Laricia, Camps, Jordi, Cappellari, Ornella, Cassano, Marco, Ciceri, Fabio, Coletta, Marcello, Covarello, Diego, Crippa, Stefania, Cusella-De Angelis, M Gabriella, De Angelis, Luciana, Dellavalle, Arianna, Diaz-Manera, Jordi, Galli, Daniela, Galli, Francesco, Gargioli, Cesare, Gerli, Mattia F M, Giacomazzi, Giorgia, Galvez, Beatriz G, Hoshiya, Hidetoshi, Guttinger, Maria, Innocenzi, Anna, Minasi, M Giulia, Perani, Laura, Previtali, Stefano C, Quattrocelli, Mattia, Ragazzi, Martina, Roostalu, Urmas, Rossi, Giuliana, Scardigli, Raffaella, Sirabella, Dario, Tedesco, Francesco Saverio, Torrente, Yvan, and Ugarte, Gonzalo
- Abstract
In 2002 we published an article describing a population of vessel-associated progenitors that we termed mesoangioblasts (MABs). During the past decade evidence had accumulated that during muscle development and regeneration things may be more complex than a simple sequence of binary choices (e.g., dorsal vs. ventral somite). LacZ expressing fibroblasts could fuse with unlabelled myoblasts but not among themselves or with other cell types. Bone marrow derived, circulating progenitors were able to participate in muscle regeneration, though in very small percentage. Searching for the embryonic origin of these progenitors, we identified them as originating at least in part from the embryonic aorta and, at later stages, from the microvasculature of skeletal muscle. While continuing to investigate origin and fate of MABs, the fact that they could be expanded in vitro (also from human muscle) and cross the vessel wall, suggested a protocol for the cell therapy of muscular dystrophies. We tested this protocol in mice and dogs before proceeding to the first clinical trial on Duchenne Muscular Dystrophy patients that showed safety but minimal efficacy. In the last years, we have worked to overcome the problem of low engraftment and tried to understand their role as auxiliary myogenic progenitors during development and regeneration.
- Published
- 2023
46. Prognostic value of Body Mass Index in stage II/III colon cancer: post-hoc analysis from the TOSCA trial
- Author
-
Basile, D., primary, Rosati, G., additional, Bergamo, F., additional, Garattini, S.K., additional, Banzi, M., additional, Zampino, M., additional, Bozzarelli, S., additional, Marchetti, P., additional, Galli, F., additional, Longarini, R., additional, Zaniboni, A., additional, Ferrari, D., additional, De Placido, S., additional, Frassineti, L., additional, Nicolini, M., additional, Cinieri, S., additional, Priscindiaro, M., additional, Ziranu, P., additional, Caccialanza, R., additional, Pastorino, A., additional, Mosconi, S., additional, and Aprile, G., additional
- Published
- 2023
- Full Text
- View/download PDF
47. The role of direct photolysis and indirect photochemistry in the environmental fate of ethylhexyl methoxy cinnamate (EHMC) in surface waters
- Author
-
Vione, D., Calza, P., Galli, F., Fabbri, D., Santoro, V., and Medana, C.
- Published
- 2015
- Full Text
- View/download PDF
48. Glutathione S-transferase pi expression regulates the Nrf2-dependent response to hormetic diselenides
- Author
-
Bartolini, D., Commodi, J., Piroddi, M., Incipini, L., Sancineto, L., Santi, C., and Galli, F.
- Published
- 2015
- Full Text
- View/download PDF
49. Gas chromatography–mass spectrometry microanalysis of alpha- and gamma-tocopherol in plasma and whole blood
- Author
-
Zerbinati, C., Galli, F., Regolanti, R., Poli, G., and Iuliano, L.
- Published
- 2015
- Full Text
- View/download PDF
50. Influence of surface characteristics of implant materials on MRSA biofilm formation and effects of antimicrobial treatment
- Author
-
Dun, S.C.J. van, Verheul, M., Pijls, B.G.C.W., Prehn, J. van, Scheper, H., Galli, F., Nibbering, P.H., and Boer, M.G.J. de
- Subjects
Microbiology (medical) ,Staphylococcus aureus ,PJI ,atomic force microscopy (AFM) ,MRSA ,Microbiology ,biofilm - Abstract
IntroductionOne of the main causes of treatment failure in bacterial prosthetic joint infections (PJI) is biofilm formation. The topography of the biofilm may be associated with susceptibility to antimicrobial treatment. The aims of this study were to assess differences in topography of biofilms on different implant materials and the correlation thereof with susceptibility to antimicrobial treatment.MethodsMethicillin-resistant Staphylococcus aureus (MRSA) 7-day mature biofilms were generated on disks made from titanium alloys (Ti-6Al-7Nb and Ti-6Al-4V), synthetic polymer and orthopedic bone cement, commonly used in implant surgery. The surface topography of these implant materials and the biofilms cultured on them was assessed using atomic force microscopy. This provided detailed images, as well as average roughness (Ra) and peak-to-valley roughness (Rt) values in nanometers, of the biofilm and the material surfaces. Bacterial counts within biofilms were assessed microbiologically. Antimicrobial treatment of biofilms was performed by 24-h exposure to the combination of rifampicin and ciprofloxacin in concentrations of 1-, 5- and 10-times the minimal bactericidal concentration (MBC). Finally, treatment-induced differences in bacterial loads and their correlation with biofilm surface parameters were assessed.ResultsThe biofilm surfaces on titanium alloys Ti-6Al-7Nb (Ra = 186 nm) and Ti-6Al-4V (Ra = 270 nm) were less rough than those of biofilms on silicone (Ra = 636 nm). The highest roughness was observed for biofilms on orthopedic bone cement with an Ra of 1,551 nm. Interestingly, the roughness parameters of the titanium alloys themselves were lower than the value for silicone, whereas the surface of the bone cement was the roughest. Treatment with 1- and 5-times the MBC of antibiotics resulted in inter-material differences in colony forming units (CFU) counts, ultimately showing comparable reductions of 2.4–3.0 log CFU/mL at the highest tested concentration. No significant differences in bacterial loads within MRSA biofilms were observed between the various implant materials, upon exposure to increasing concentrations of antibiotics.DiscussionThe surface parameters of MRSA biofilms were determined by those of the implant materials on which they were formed. The antibiotic susceptibility of MRSA biofilms on the various tested implant materials did not differ, indicating that the efficacy of antibiotics was not affected by the roughness of the biofilm.
- Published
- 2023
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.