2,175 results on '"Gallo C."'
Search Results
2. Under-reporting of subjective symptoms and its prognostic value: a pooled analysis of 12 cancer clinical trials
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Arenare, L., Di Liello, R., De Placido, P., Gridelli, C., Morabito, A., Pignata, S., Nuzzo, F., Avallone, A., Maiello, E., Gargiulo, P., Schettino, C., Gravina, A., Gallo, C., Chiodini, P., Di Maio, M., Perrone, F., and Piccirillo, M.C.
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- 2024
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3. Immersive Technology-Based Guidance Module for Induction Motor Diagnosing
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Naranjo, Jose-E., Caiza, Gustavo, Gallo-C., Veronica, Alvarez-T., Santiago, Lopez, Wilson-O., Garcia, Marcelo-V., Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Garcia, Marcelo V., editor, and Gordón-Gallegos, Carlos, editor
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- 2023
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4. Confirmatory validation analysis of the PROFFIT questionnaire to assess financial toxicity in cancer patients
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Arenare, L., Porta, C., Barberio, D., Terzolo, S., Zagonel, V., Pisconti, S., Del Mastro, L., Pinto, C., Bilancia, D., Cinieri, S., Rizzo, M., Migliaccio, G., Montesarchio, V., Del Campo, L., De Lorenzo, F., Iannelli, E., Traclò, F., Gitto, L., Vaccaro, M.C., Frontini, L., Giannarelli, D., Bryce, J., Piccirillo, M.C., Jommi, C., Efficace, F., Riva, S., Di Maio, M., Gallo, C., and Perrone, F.
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- 2023
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5. Self-consistent simulations of ECR-based charge breeders: evidence and impact of the plasmoid-halo structure
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Galatà, A., Gallo, C. S., Mascali, D., Torrisi, G., and Caldara, M.
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Physics - Plasma Physics ,Physics - Computational Physics - Abstract
This paper discusses the capture of an ion beam in a magnetized plasma of an Electron Cyclotron Resonance Ion Source based Charge Breeder, as modelled by numerical simulations. As a relevant step forward with respect to previous works, here the capture is modeled by considering a plasma structure determined in a self-consisent way. The plasmoid-halo structure of the ECR plasma - that is consisting of a dense core (the plasmoid) surrounded by a rarefied halo - is further confirmed by the self-consistent calculations, having also some fine structures affected by the electromagnetic field distribution and by the magnetostatic field profile. The capture of Rb1+ ions has been investigated in details, vs. various plasma parameters, and then compared to experimental results., Comment: New results about a self-consistent modeling of magnetized plasmas
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- 2019
6. Operation of a ferromagnetic axion haloscope at $m_a=58\,\mu$eV
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Crescini, N., Alesini, D., Braggio, C., Carugno, G., Di Gioacchino, D., Gallo, C. S., Gambardella, U., Gatti, C., Iannone, G., Lamanna, G., Ligi, C., Lombardi, A., Ortolan, A., Pagano, S., Pengo, R., Ruoso, G., Speake, C. C., and Taffarello, L.
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High Energy Physics - Experiment ,Physics - Instrumentation and Detectors - Abstract
Axions, originally proposed to solve the strong CP problem of quantum chromodynamics, emerge now as leading candidates of WISP dark matter. The rich phenomenology associated to the light and stable QCD axion can be described as an effective magnetic field that can be experimentally investigated. For the QUAX experiment, dark matter axions are searched by means of their resonant interactions with electronic spins in a magnetized sample. In principle, axion-induced magnetization changes can be detected by embedding a sample in an rf cavity in a static magnetic field. In this work we describe the operation of a prototype ferromagnetic haloscope, with a sensitivity limited by thermal fluctuations and receiver noise. With a preliminary dark matter search, we are able to set an upper limit on the coupling constant of DFSZ axions to electrons $g_{aee}<4.9\times10^{-10}$ at 95\% C.L. for a mass of $58\,\mu$eV (i.\,e. 14\,GHz). This is the first experimental result with an apparatus exploiting the coupling between cosmological axions and electrons., Comment: 10 pages, 8 figures
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- 2018
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7. Microwave cavity tuned with liquid metal and its application to Electron Paramagnetic Resonance
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Gallo, C. S., Berto, E., Braggio, C., Calaon, F., Carugno, G., Crescini, N., Ortolan, A., Ruoso, G., and Tessaro, M.
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Physics - Instrumentation and Detectors ,Physics - Applied Physics - Abstract
This note presents a method to tune the resonant frequency $f_{0}$ of a rectangular microwave cavity. This is achieved using a liquid metal, GaInSn, to decrease the volume of the cavity. It is possible to shift $f_{0}$ by filling the cavity with this alloy, in order to reduce the relative distance between the internal walls. The resulting modes have resonant frequencies in the range $7\div8\,$GHz. The capability of the system of producing an Electron Paramagnetic Resonance (EPR) measurement has been tested by placing a 1 mm diameter Yttrium Iron Garnet (YIG) sphere inside the cavity, and producing a strong coupling between the cavity resonance and Kittel mode. This work shows the possibility to tune a resonant system in the GHz range, which can be useful for several applications., Comment: 7 Pages, 5 Figures
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- 2018
8. Immersive Technology-Based Guidance Module for Induction Motor Diagnosing
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Naranjo, Jose-E., primary, Caiza, Gustavo, additional, Gallo-C., Veronica, additional, Alvarez-T., Santiago, additional, Lopez, Wilson-O., additional, and Garcia, Marcelo-V., additional
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- 2023
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9. Ultrasound muscle assessment for sarcopenia detection in inflammatory bowel disease: A prospective study
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Mulinacci, G, Pirola, L, Gandola, D, Ippolito, D, Vigano, C, Laffusa, A, Gallo, C, Invernizzi, P, Danese, S, Massironi, S, Mulinacci G., Pirola L., Gandola D., Ippolito D., Vigano C., Laffusa A., Gallo C., Invernizzi P., Danese S., Massironi S., Mulinacci, G, Pirola, L, Gandola, D, Ippolito, D, Vigano, C, Laffusa, A, Gallo, C, Invernizzi, P, Danese, S, Massironi, S, Mulinacci G., Pirola L., Gandola D., Ippolito D., Vigano C., Laffusa A., Gallo C., Invernizzi P., Danese S., and Massironi S.
- Abstract
Background: Sarcopenia is prevalent in patients with inflammatory bowel disease (IBD) and impacts surgical and therapeutic outcomes; thus, effective diagnostic tools are needed to assess muscle mass and function in this population. Methods: 153 consecutive patients were included, 100 in the training cohort and 53 in the study cohort. Three superficial muscles (rectus femoris = RF, rectus abdominis = RA, and biceps brachii = BB) were selected for the detection of sarcopenia using muscle ultrasound (US). The training cohort consisted of consecutive patients with or without IBD and was used to evaluate the feasibility and inter- and intra-observer variability of the US measurement. The study cohort consisted of only IBD patients and served to test US diagnostic accuracy. In the latter, muscle US, bioelectrical impedance analysis (BIA), and magnetic resonance imaging (MRI) were used to measure muscle parameters. Results: Sarcopenia prevalence in IBD patients was 50%. Muscle US showed excellent inter-rater and intra-rater reliability (ICC >0.95) and a good diagnostic accuracy in detecting sarcopenia compared to BIA with area under the receiver operating characteristic curve (AUROC) values of 80% and 85% for RA and BB thickness, respectively. Moreover, an Ultrasound Muscle Index (USMI) was defined as the sum of the RA, BB, and RF thickness divided by the square of the patient's height, resulting in an AUROC of 81%. Muscle thresholds for sarcopenia were detected, with RA and USMI values correlated with the highest positive (84.3%) and negative (99%) predictive values, respectively. Additionally, the agreement between the US and MRI measurements of RA was excellent (ICC 0.96). Conclusions: The findings of this study emphasize the potential of muscle US as a reliable diagnostic tool for assessing sarcopenia in IBD patients. This research has significant implications for disease management in IBD patients and underscores the need for further i
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- 2024
10. Participant Engagement and Symptom Improvement: Aripiprazole Tablets with Sensor for the Treatment of Schizophrenia
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Cochran JM, Fang H, Le Gallo C, Peters-Strickland T, Lindenmayer JP, and Reuteman-Fowler JC
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digital medicine ,medication ingestion ,treatment utilization ,positive and negative syndrome scale ,Medicine (General) ,R5-920 - Abstract
Jeffrey M Cochran,1 Hui Fang,2 Christophe Le Gallo,3 Timothy Peters-Strickland,4 Jean-Pierre Lindenmayer,5 J Corey Reuteman-Fowler6 1Medical & Real World Data Analytics, Otsuka Pharmaceutical Development & Commercialization, Inc., Princeton, NJ, USA; 2Biostatistics, Otsuka Pharmaceutical Development & Commercialization, Inc., Princeton, NJ, USA; 3Clinical Programming, Otsuka Pharmaceutical Development & Commercialization, Inc., Princeton, NJ, USA; 4PPD, Inc., Wilmington, NC, USA; 5Department of Psychiatry, New York University Grossman School of Medicine, New York, NY, USA; 6Global Clinical Development, Otsuka Pharmaceutical Development & Commercialization, Inc., Princeton, NJ, USACorrespondence: Jeffrey M Cochran, Medical & Real World Data Analytics, Otsuka Pharmaceutical Development & Commercialization, Inc., 508 Carnegie Center, Princeton, NJ, 08540, USA, Tel +1 609 535 9035, Email Jeffrey.Cochran@otsuka-us.comPurpose: A recent, phase 3b, mirror-image clinical trial of outpatients with schizophrenia found that use of aripiprazole tablets with sensor (AS; Abilify MyCite®, comprising an ingestible event-marker sensor embedded in aripiprazole tablets, wearable sensor patches, and a smartphone application) reduced the incidence of psychiatric hospitalizations relative to oral standard-of-care antipsychotics. This analysis explored the relationship between AS engagement by participants and changes in participant performance and symptom-severity measures assessed by clinical raters.Participants and Methods: This post hoc analysis used prospectively collected clinical data from a phase 3b clinical trial (NCT03892889). Outpatients had schizophrenia, were aged 18– 65 years, and had ≥ 1 psychiatric hospitalization in the previous 48 months. Participants were grouped by study completion status and a k-means clustering algorithm based on AS utilization, resulting in 3 groups: discontinued (discontinued AS before month 3 of the study); moderate engagement (completed 3 months, used AS intermittently); and high engagement (completed 3 months, used AS regularly). Baseline to end-of-study differences for the Clinical Global Impression Scale (Severity of Illness and Improvement of Illness scales), Personal and Social Performance Scale, and Positive and Negative Syndrome Scale were calculated.Results: A total of 277 outpatients were enrolled (discontinued, n = 164; moderate engagement, n = 63; high engagement, n = 50). All groups experienced symptom improvement from baseline to end-of-study, with significant changes in the more-engaged groups. Highly engaged participants showed significant improvement for all clinical scores and subscores (all P < 0.05) and demonstrated significantly more improvement in symptoms than participants with less engagement.Conclusion: Participants who completed 3 months of the study and had higher AS engagement experienced significantly greater improvement in their end-of-study clinical assessments versus participants who did not complete 3 months. Improvement may be related to more-consistent medication intake and better engagement with a digital health system.Keywords: digital medicine, medication ingestion, treatment utilization, Positive and Negative Syndrome Scale
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- 2022
11. Searching for galactic axions through magnetized media: the QUAX proposal
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Barbieri, R., Braggio, C., Carugno, G., Gallo, C. S., Lombardi, A., Ortolan, A., Pengo, R., Ruoso, G., and Speake, C. C.
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High Energy Physics - Phenomenology ,High Energy Physics - Experiment - Abstract
We present a proposal to search for QCD axions with mass in the 200 $\mu$eV range, assuming that they make a dominant component of dark matter. Due to the axion-electron spin coupling, their effect is equivalent to the application of an oscillating rf field with frequency and amplitude fixed by the axion mass and coupling respectively. This equivalent magnetic field would produce spin flips in a magnetic sample placed inside a static magnetic field, which determines the resonant interaction at the Larmor frequency. Spin flips would subsequently emit radio frequency photons that can be detected by a suitable quantum counter in an ultra-cryogenic environment. This new detection technique is crucial to keep under control the thermal photon background which would otherwise produce a too large noise., Comment: To appear on Physics of the Dark Universe
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- 2016
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12. Nanocomposite hyaluronic acid-based hydrogel for the treatment of esophageal fistulas
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Piantanida, E., Boškoski, I., Quero, G., Gallo, C., Zhang, Y., Fiorillo, C., Arena, V., Costamagna, G., Perretta, S., and De Cola, L.
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- 2021
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13. Carboplatin-based doublet plus bevacizumab beyond progression versus carboplatin-based doublet alone in patients with platinum-sensitive ovarian cancer: a randomised, phase 3 trial
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Pignata, S, Lorusso, D, Joly, F, Gallo, C, Colombo, N, Sessa, C, Bamias, A, Salutari, V, Selle, F, Frezzini, S, De Giorgi, U, Pautier, P, Bologna, A, Orditura, M, Dubot, C, Gadducci, A, Mammoliti, S, Ray-Coquard, I, Zafarana, E, Breda, E, Favier, L, Ardizzoia, A, Cinieri, S, Largillier, R, Sambataro, D, Guardiola, E, Lauria, R, Pisano, C, Raspagliesi, F, Scambia, G, Daniele, G, Perrone, F, Pignata, Sandro, Lorusso, Domenica, Joly, Florence, Gallo, Ciro, Colombo, Nicoletta, Sessa, Cristiana, Bamias, Aristotelis, Salutari, Vanda, Selle, Frédèric, Frezzini, Simona, De Giorgi, Ugo, Pautier, Patricia, Bologna, Alessandra, Orditura, Michele, Dubot, Coraline, Gadducci, Angiolo, Mammoliti, Serafina, Ray-Coquard, Isabelle, Zafarana, Elena, Breda, Enrico, Favier, Laure, Ardizzoia, Antonio, Cinieri, Saverio, Largillier, Rémy, Sambataro, Daniela, Guardiola, Emmanuel, Lauria, Rossella, Pisano, Carmela, Raspagliesi, Francesco, Scambia, Giovanni, Daniele, Gennaro, and Perrone, Francesco
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- 2021
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14. Chapter 2: Cattle
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Gallo, C., primary, Schwartzkopf-Genswein, K., additional, and Gibson, T., additional
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- 2022
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15. Calf- and herd-level factors associated with dairy calf reactivity
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Calderón-Amor, J., Beaver, A., von Keyserlingk, M.A.G., and Gallo, C.
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- 2020
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16. European effort to improve highly charged heavy ion beam capabilities with ECR ion sources (invited)
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Koivisto, H., primary, Andreev, A., additional, Asfari, Z., additional, Biri, S., additional, Celona, L., additional, Charbonnière, L., additional, Charpentier, C., additional, Dubois, M., additional, Filliger, M., additional, Galatà, A., additional, Gall, B., additional, Gallo, C. S., additional, Galonska, M., additional, Gammino, S., additional, Gerbershagen, A., additional, Jones, B.N., additional, Kalvas, T., additional, Kremers, H.R., additional, Kronholm, R., additional, Lang, R., additional, Lemagnen, F., additional, Leonardi, O., additional, Maimone, F., additional, Mascali, D., additional, Mäder, J., additional, Naselli, E., additional, Pidatella, A., additional, Rácz, R., additional, Thuillier, T., additional, Timonen, O., additional, Toivanen, V., additional, and Torrisi, G., additional
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- 2024
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17. First numerical evidence of the two-close frequency heating effect on electron cyclotron resonance ion sources
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Galatà, A, primary, Biri, S, additional, Finocchiaro, G, additional, Gallo, C S, additional, Mascali, D, additional, Mishra, B, additional, Naselli, E, additional, Pidatella, A, additional, Rácz, R, additional, and Torrisi, G, additional
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- 2024
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18. OC.15.3: INCIDENCE AND CHARACTERISTICS OF ENDOSCOPIC GASTRIC POLYPS IN PATIENTS WITH AUTOIMMUNE ATROPHIC GASTRITIS: A MULTICENTRIC RETROSPECTIVE STUDY
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Massironi, S., primary, Gallo, C., additional, Lahner, E., additional, Sciola, V., additional, Cavalcoli, F., additional, Lenti, M.V., additional, Miceli, E., additional, Zilli, A., additional, Dottori, L., additional, De Rossi, G., additional, Annibale, B., additional, Vecchi, M., additional, Cantù, P., additional, Di Sabatino, A., additional, Invernizzi, P., additional, and Danese, S., additional
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- 2024
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19. T.06.10: ENDOSCOPIC TREATMENT OF HSIL IN HIV+/HIV- PATIENTS: A CASE SERIES
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Conti, C.B., primary, Squillace, N., additional, Gallo, C., additional, Redaelli, A.E., additional, Maino, M., additional, Frego, R., additional, Mulinacci, G., additional, and Dinelli, M.E., additional
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- 2024
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20. Assessing the Frequency of Type I Gastric Neuroendocrine Neoplasms in Autoimmune Atrophic Gastritis: A Multi-Center Study in Italy
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Massironi, S., additional, Gallo, C., additional, Lahner, E., additional, Sciola, V., additional, Cavalcoli, F., additional, Lenti, M. V., additional, Miceli, E., additional, Zilli, A., additional, Dottori, L., additional, De Rossi, G., additional, Annibale, B., additional, Vecchi, M., additional, Cantù, P., additional, Di Sabatino, A., additional, Invernizzi, P., additional, and Danese, S., additional
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- 2024
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21. Incidence and Characteristics of Endoscopic Gastric Polyps in Patients with Autoimmune Atrophic Gastritis: A Multicentric Retrospective Study
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Massironi, S., additional, Gallo, C., additional, Lahner, E., additional, Sciola, V., additional, Cavalcoli, F., additional, Lenti, M. V., additional, Miceli, E., additional, Zilli, A., additional, Dottori, L., additional, De Rossi, G., additional, Annibale, B., additional, Vecchi, M., additional, Cantù, P., additional, Di Sabatino, A., additional, Invernizzi, P., additional, and Danese, S., additional
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- 2024
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22. BOC.03.2: ULTRASOUND MUSCLE ASSESSMENT FOR SARCOPENIA SCREENING IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE: A PROSPECTIVE STUDY (SARCUS-IBD)
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Mulinacci, G., primary, Pirola, L., additional, Gandola, D., additional, Ippolito, D., additional, Viganò, C., additional, Laffusa, A., additional, Gallo, C., additional, Invernizzi, P., additional, Danese, S., additional, and Massironi, S., additional
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- 2024
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23. Abstract No. 232 Technical Success, Safety, and Outcomes of Cryoprobe-Assisted Renal Displacement to Protect Critical Adjacent Structures During Renal Cryoablation
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Gallo, C., primary, Ronald, J., additional, Cline, B., additional, Martin, J., additional, Sag, A., additional, Befera, N., additional, Johnson, D., additional, and Kim, C., additional
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- 2024
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24. Deficient Reasoning for Dark Matter in Galaxies
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Feng, James Q. and Gallo, C. F.
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Astrophysics - Astrophysics of Galaxies - Abstract
Astronomers have been using the measured luminosity to estimate the {\em luminous mass} of stars, based on empirically established mass-to-light ratio which seems to be only applicable to a special class of stars---the main-sequence stars---with still considerable uncertainties. Another basic tool to determine the mass of a system of stars or galaxies comes from the study of their motion, as Newton demonstrated with his law of gravitation, which yields the {\em gravitational mass}. Because the luminous mass can at best only represent a portion of the gravitational mass, finding the luminous mass to be different or less than the gravitational mass should not be surprising. Using such an apparent discrepancy as a compelling evidence for the so-called dark matter, which has been believed to possess mysterious nonbaryonic properties and present a dominant amount in galaxies and the universe, seems to be too far a stretch when seriously examining the facts and uncertainties in the measurement techniques. In our opinion, a galaxy with star type distribution varying from its center to edge may have a mass-to-light ratio varying accordingly. With the thin-disk model computations based on measured rotation curves, we found that most galaxies have a typical mass density profile that peaks at the galactic center and decreases rapidly within $\sim 5%$ of the cut-off radius, and then declines nearly exponentially toward the edge. The predicted mass density in the Galactic disk is reasonably within the reported range of that observed in interstellar medium. This leads us to believe that ordinary baryonic matter can be sufficient for supporting the observed galactic rotation curves; speculation of large amount of non-baryonic matter may be based on an ill-conceived discrepancy between gravitational mass and luminous mass which appears to be unjustified.
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- 2014
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25. Exploring the genetics of lithium response in bipolar disorders
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Herrera-Rivero, M, Adli, M, Akiyama, K, Akula, N, Amare, AT, Ardau, R, Arias, B, Aubry, JM, Backlund, L, Bellivier, F, Benabarre, A, Bengesser, S, Bhattacharjee, AK, Biernacka, JM, Birner, A, Cearns, M, Cervantes, P, Chen, HC, Chillotti, C, Cichon, S, Clark, SR, Colom, F, Cruceanu, C, Czerski, PM, Dalkner, N, Degenhardt, F, Del Zompo, M, DePaulo, JR, Etain, B, Falkai, P, Ferensztajn-Rochowiak, E, Forstner, AJ, Frank, J, Frisén, L, Frye, MA, Fullerton, JM ; https://orcid.org/0000-0003-4014-4490, Gallo, C, Gard, S, Garnham, JS, Goes, FS, Grigoroiu-Serbanescu, M, Grof, P, Hashimoto, R, Hasler, R, Hauser, J, Heilbronner, U, Herms, S, Hoffmann, P, Hou, L, Hsu, YH, Jamain, S, Jiménez, E, Kahn, JP, Kassem, L, Kato, T, Kelsoe, J, Kittel-Schneider, S, Kuo, PH, Kusumi, I, König, B, Laje, G, Landén, M, Lavebratt, C, Leboyer, M, Leckband, SG, Maj, M, Manchia, M, Marie-Claire, C, Martinsson, L, McCarthy, MJ, McElroy, SL, Millischer, V, Mitjans, M, Mondimore, FM, Monteleone, P, Nievergelt, CM, Novák, T, Nöthen, MM, O’Donovan, C, Ozaki, N, Papiol, S, Pfennig, A, Pisanu, C, Potash, JB, Reif, A, Reininghaus, E, Richard-Lepouriel, H, Roberts, G ; https://orcid.org/0000-0002-1966-5120, Rouleau, GA, Rybakowski, JK, Schalling, M, Schofield, PR, Schubert, KO, Schulte, EC, Schweizer, BW, Severino, G, Shekhtman, T, Shilling, PD, Shimoda, K, Simhandl, C, Mitchell, Philip ; https://orcid.org/0000-0002-7954-5235, Herrera-Rivero, M, Adli, M, Akiyama, K, Akula, N, Amare, AT, Ardau, R, Arias, B, Aubry, JM, Backlund, L, Bellivier, F, Benabarre, A, Bengesser, S, Bhattacharjee, AK, Biernacka, JM, Birner, A, Cearns, M, Cervantes, P, Chen, HC, Chillotti, C, Cichon, S, Clark, SR, Colom, F, Cruceanu, C, Czerski, PM, Dalkner, N, Degenhardt, F, Del Zompo, M, DePaulo, JR, Etain, B, Falkai, P, Ferensztajn-Rochowiak, E, Forstner, AJ, Frank, J, Frisén, L, Frye, MA, Fullerton, JM ; https://orcid.org/0000-0003-4014-4490, Gallo, C, Gard, S, Garnham, JS, Goes, FS, Grigoroiu-Serbanescu, M, Grof, P, Hashimoto, R, Hasler, R, Hauser, J, Heilbronner, U, Herms, S, Hoffmann, P, Hou, L, Hsu, YH, Jamain, S, Jiménez, E, Kahn, JP, Kassem, L, Kato, T, Kelsoe, J, Kittel-Schneider, S, Kuo, PH, Kusumi, I, König, B, Laje, G, Landén, M, Lavebratt, C, Leboyer, M, Leckband, SG, Maj, M, Manchia, M, Marie-Claire, C, Martinsson, L, McCarthy, MJ, McElroy, SL, Millischer, V, Mitjans, M, Mondimore, FM, Monteleone, P, Nievergelt, CM, Novák, T, Nöthen, MM, O’Donovan, C, Ozaki, N, Papiol, S, Pfennig, A, Pisanu, C, Potash, JB, Reif, A, Reininghaus, E, Richard-Lepouriel, H, Roberts, G ; https://orcid.org/0000-0002-1966-5120, Rouleau, GA, Rybakowski, JK, Schalling, M, Schofield, PR, Schubert, KO, Schulte, EC, Schweizer, BW, Severino, G, Shekhtman, T, Shilling, PD, Shimoda, K, Simhandl, C, and Mitchell, Philip ; https://orcid.org/0000-0002-7954-5235
- Abstract
Background: Lithium (Li) remains the treatment of choice for bipolar disorders (BP). Its mood-stabilizing effects help reduce the long-term burden of mania, depression and suicide risk in patients with BP. It also has been shown to have beneficial effects on disease-associated conditions, including sleep and cardiovascular disorders. However, the individual responses to Li treatment vary within and between diagnostic subtypes of BP (e.g. BP-I and BP-II) according to the clinical presentation. Moreover, long-term Li treatment has been linked to adverse side-effects that are a cause of concern and non-adherence, including the risk of developing chronic medical conditions such as thyroid and renal disease. In recent years, studies by the Consortium on Lithium Genetics (ConLiGen) have uncovered a number of genetic factors that contribute to the variability in Li treatment response in patients with BP. Here, we leveraged the ConLiGen cohort (N = 2064) to investigate the genetic basis of Li effects in BP. For this, we studied how Li response and linked genes associate with the psychiatric symptoms and polygenic load for medical comorbidities, placing particular emphasis on identifying differences between BP-I and BP-II. Results: We found that clinical response to Li treatment, measured with the Alda scale, was associated with a diminished burden of mania, depression, substance and alcohol abuse, psychosis and suicidal ideation in patients with BP-I and, in patients with BP-II, of depression only. Our genetic analyses showed that a stronger clinical response to Li was modestly related to lower polygenic load for diabetes and hypertension in BP-I but not BP-II. Moreover, our results suggested that a number of genes that have been previously linked to Li response variability in BP differentially relate to the psychiatric symptomatology, particularly to the numbers of manic and depressive episodes, and to the polygenic load for comorbid conditions, including diabetes, hyperte
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- 2024
26. Immunogenetics of lithium response and psychiatric phenotypes in patients with bipolar disorder
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Herrera-Rivero, M, Gutiérrez-Fragoso, K, Kurtz, J, Baune, BT, Thalamuthu, A ; https://orcid.org/0000-0002-7114-1260, Amare, AT, Adli, M, Akiyama, K, Akula, N, Ardau, R, Arias, B, Aubry, JM, Backlund, L, Bellivier, F, Benabarre, A, Bengesser, S, Bhattacharjee, AK, Biernacka, JM, Birner, A, Cearns, M, Cervantes, P, Chen, HC, Chillotti, C, Cichon, S, Clark, SR, Colom, F, Cruceanu, C, Czerski, PM, Dalkner, N, Degenhardt, F, Del Zompo, M, DePaulo, JR, Etain, B, Falkai, P, Ferensztajn-Rochowiak, E, Forstner, AJ, Frank, J, Frisén, L, Frye, MA, Fullerton, JM ; https://orcid.org/0000-0003-4014-4490, Gallo, C, Gard, S, Garnham, JS, Goes, FS, Grigoroiu-Serbanescu, M, Grof, P, Hashimoto, R, Hasler, R, Hauser, J, Heilbronner, U, Herms, S, Hoffmann, P, Hou, L, Hsu, YH, Jamain, S, Jiménez, E, Kahn, JP, Kassem, L, Kato, T, Kelsoe, J, Kittel-Schneider, S, Kuo, PH, Kusumi, I, König, B, Laje, G, Landén, M, Lavebratt, C, Leboyer, M, Leckband, SG, Maj, M, Manchia, M, Marie-Claire, C, Martinsson, L, McCarthy, MJ, McElroy, SL, Millischer, V, Mitjans, M, Mondimore, FM, Monteleone, P, Nievergelt, CM, Novák, T, Nöthen, MM, O’Donovan, C, Ozaki, N, Papiol, S, Pfennig, A, Pisanu, C, Potash, JB, Reif, A, Reininghaus, E, Richard-Lepouriel, H, Roberts, G ; https://orcid.org/0000-0002-1966-5120, Rouleau, GA, Rybakowski, JK, Schalling, M, Schofield, PR ; https://orcid.org/0000-0003-2967-9662, Schubert, KO, Schulte, EC, Schweizer, BW, Severino, G, Mitchell, Philip ; https://orcid.org/0000-0002-7954-5235, Herrera-Rivero, M, Gutiérrez-Fragoso, K, Kurtz, J, Baune, BT, Thalamuthu, A ; https://orcid.org/0000-0002-7114-1260, Amare, AT, Adli, M, Akiyama, K, Akula, N, Ardau, R, Arias, B, Aubry, JM, Backlund, L, Bellivier, F, Benabarre, A, Bengesser, S, Bhattacharjee, AK, Biernacka, JM, Birner, A, Cearns, M, Cervantes, P, Chen, HC, Chillotti, C, Cichon, S, Clark, SR, Colom, F, Cruceanu, C, Czerski, PM, Dalkner, N, Degenhardt, F, Del Zompo, M, DePaulo, JR, Etain, B, Falkai, P, Ferensztajn-Rochowiak, E, Forstner, AJ, Frank, J, Frisén, L, Frye, MA, Fullerton, JM ; https://orcid.org/0000-0003-4014-4490, Gallo, C, Gard, S, Garnham, JS, Goes, FS, Grigoroiu-Serbanescu, M, Grof, P, Hashimoto, R, Hasler, R, Hauser, J, Heilbronner, U, Herms, S, Hoffmann, P, Hou, L, Hsu, YH, Jamain, S, Jiménez, E, Kahn, JP, Kassem, L, Kato, T, Kelsoe, J, Kittel-Schneider, S, Kuo, PH, Kusumi, I, König, B, Laje, G, Landén, M, Lavebratt, C, Leboyer, M, Leckband, SG, Maj, M, Manchia, M, Marie-Claire, C, Martinsson, L, McCarthy, MJ, McElroy, SL, Millischer, V, Mitjans, M, Mondimore, FM, Monteleone, P, Nievergelt, CM, Novák, T, Nöthen, MM, O’Donovan, C, Ozaki, N, Papiol, S, Pfennig, A, Pisanu, C, Potash, JB, Reif, A, Reininghaus, E, Richard-Lepouriel, H, Roberts, G ; https://orcid.org/0000-0002-1966-5120, Rouleau, GA, Rybakowski, JK, Schalling, M, Schofield, PR ; https://orcid.org/0000-0003-2967-9662, Schubert, KO, Schulte, EC, Schweizer, BW, Severino, G, and Mitchell, Philip ; https://orcid.org/0000-0002-7954-5235
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- 2024
27. Impaired coronary blood flow at higher heart rates during atrial fibrillation: Investigation via multiscale modelling
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Scarsoglio, S., Gallo, C., Saglietto, A., Ridolfi, L., and Anselmino, M.
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- 2019
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28. Mass distribution in rotating thin-disk galaxies according to Newtonian dynamics
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Feng, James Q. and Gallo, C. F.
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Astrophysics - Astrophysics of Galaxies - Abstract
An accurate computational method is presented to determine the mass distribution in a rotating thin-disk galaxy from given rotation curve by applying Newtonian dynamics for an axisymmetrically rotating thin disk of finite size with or without a central spherical bulge. The governing integral equation for mass distribution, resulting from the balance between the Newtonian gravitational force and centrifugal force due to rotation at every point on the disk, is transformed via a boundary-element method into a linear algebra matrix equation that can be solved numerically for rotation curves with a wide range of shapes. To illustrate the effectiveness of this computational method, mass distributions in several mature spiral galaxies are determined from their measured rotation curves. All the surface mass density profiles predicted by our model exhibit approximately a common exponential law of decay, qualitatively consistent with the observed surface brightness distributions. When a central spherical bulge is present, the total galactic mass increases only slightly but the mass distribution in the galaxy is altered in such a way that the periphery mass density is reduced while more mass appears toward the galactic center. By extending the computational domain beyond the galactic edge, we can determine rotation velocity outside the cut-off radius which appears to continuously decrease and gradually approach the Keplerian rotation velocity out over twice the cut-off radius. Am examination of the circular orbit stability suggests that galaxies with flat or increasing rotation velocities with radius are more stable than those with decreasing rotation velocities especially in the region near the galactic edge. Our results demonstrate the fact that Newtonian dynamics can be adequate for describing the observed rotation behavior of mature spiral galaxies., Comment: 24 pages, 9 figures
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- 2012
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29. Modeling the Newtonian Dynamics for Rotation Curve Analysis of Thin-Disk Galaxies
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Feng, James Q. and Gallo, C. F.
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Astrophysics - Astrophysics of Galaxies ,Mathematical Physics - Abstract
We present an efficient, robust computational method for modeling the Newtonian dynamics for rotation curve analysis of thin-disk galaxies. For a disk galaxy with a typical flat rotation curve, our modeling results show that the surface mass density monotonically decreases from the galactic center toward periphery, according to Newtonian dynamics. In a large portion of the galaxy, the surface mass density follows an approximately exponential law of decay with respect to the galactic radial coordinate. Yet the radial scale length for the surface mass density seems to be generally larger than that of the measured brightness distribution, suggesting an increasing mass-to-light ratio with the radial distance in a disk galaxy. In a nondimensionalized form, our mathematical system contains a dimensionless parameter which we call the "galactic rotation number" that represents the gross ratio of centrifugal force and gravitational force. The value of this galactic rotation number is determined as part of the numerical solution. Through a systematic computational analysis, we have illustrated that this galactic rotation number remains within $\pm 10%$ of 1.70 for a wide variety of rotation curves. This implies that the total mass in a disk galaxy is proportional to $V_0^2\,R_g$, with $V_0$ denoting the characteristic rotation velocity and $R_g$ the radius of the galactic disk. The predicted total galactic mass of the Milky Way is in good agreement with the star-count data., Comment: 20 pages, 7 figures
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- 2011
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30. Rotating thin-disk galaxies through the eyes of Newton
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Feng, James Q. and Gallo, C. F.
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Astrophysics - Galaxy Astrophysics - Abstract
By numerically solving the mass distribution in a rotating disk based on Newton's laws of motion and gravitation, we demonstrate that the observed flat rotation curves for most spiral galaxies correspond to exponentially decreasing mass density from galactic center for the most of the part except within the central core and near periphery edge. Hence, we believe the galaxies described with our model are consistent with that seen through the eyes of Newton. Although Newton's laws and Kepler's laws seem to yield the same results when they are applied to the planets in the solar system, they are shown to lead to quite different results when describing the stellar dynamics in disk galaxies. This is because that Keplerian dynamics may be equivalent to Newtonian dynamics for only special circumstances, but not generally for all the cases. Thus, the conclusions drawn from calculations based on Keplerian dynamics are often likely to be erroneous when used to describe rotating disk galaxies., Comment: 19 pages, 6 figures
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- 2010
31. Carboplatin and paclitaxel plus avelumab compared with carboplatin and paclitaxel in advanced or recurrent endometrial cancer (MITO END-3): a multicentre, open-label, randomised, controlled, phase 2 trial
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Pignata, S, Scambia, G, Schettino, C, Arenare, L, Pisano, C, Lombardi, D, De Giorgi, U, Andreetta, C, Cinieri, S, De Angelis, C, Priolo, D, Casanova, C, Rosati, M, Greco, F, Zafarana, E, Schiavetto, I, Mammoliti, S, Cecere, S, Salutari, V, Scalone, S, Farolfi, A, Di Napoli, M, Lorusso, D, Gargiulo, P, Califano, D, Russo, D, Spina, A, De Cecio, R, Chiodini, P, Perrone, F, Accinno, V, Altavilla, C, Antonelli, G, Artioli, G, Avola, F, Barbara, B, Barbato, V, Bartoletti, M, Bevilacqua, S, Bordonaro, R, Borghese, O, Buonfanti, G, Camarda, F, Canzanella, G, Carbone, V, Carbone, M, Carlo Stella, G, Cassani, C, Castagna, F, Cattaneo, M, Cinefra, M, Colombo, N, Corsetti, S, Dall'Agata, M, D'Amico, M, Daniele, G, De Marino, E, De Matteis, G, De Placido, S, Del Bene, G, Del Giudice, A, Del Monte, F, Del Sesto, M, Donini, M, Drudi, G, Falcone, G, Favaretto, A, Ferrera, G, Florio, M, Forestieri, V, Gallo, M, Gallo, C, Garibaldi, F, Gerevini, F, Ghizzoni, V, Giganti, M, Gimigliano, A, Giudice, E, Gnocchi, N, Gravina, A, Greggi, S, Iaia, M, Ilardi, A, Iovine, G, Ippoliti, G, Irollo, G, Isidori, I, Lapresa, M, Lavenia, G, Longhitano, L, Lucia, B, Luzi, G, Mariano, S, Marino, V, Marrapese, G, Martino, M, Matocci, R, Mazzoni, E, Mercuri, D, Mirto, M, Pignata S., Scambia G., Schettino C., Arenare L., Pisano C., Lombardi D., De Giorgi U., Andreetta C., Cinieri S., De Angelis C., Priolo D., Casanova C., Rosati M., Greco F., Zafarana E., Schiavetto I., Mammoliti S., Cecere S. C., Salutari V., Scalone S., Farolfi A., Di Napoli M., Lorusso D., Gargiulo P., Califano D., Russo D., Spina A., De Cecio R., Chiodini P., Perrone F., Accinno V., Altavilla C., Antonelli G., Artioli G., Avola F., Barbara B., Barbato V., Bartoletti M., Bevilacqua S., Bordonaro R., Borghese O., Buonfanti G., Camarda F., Canzanella G., Carbone V., Carbone M. R., Carlo Stella G., Cassani C., Castagna F., Cattaneo M., Cinefra M., Colombo N., Corsetti S., Dall'Agata M., D'Amico M., Daniele G., De Marino E., De Matteis G., De Placido S., Del Bene G., Del Giudice A., Del Monte F., Del Sesto M., Donini M., Drudi G., Falcone G., Favaretto A., Ferrera G., Florio M., Forestieri V., Gallo M. S., Gallo C., Garibaldi F., Gerevini F., Ghizzoni V., Giganti M. O., Gimigliano A., Giudice E., Gnocchi N., Gravina A., Greggi S., Iaia M. L., Ilardi A., Iovine G., Ippoliti G., Irollo G., Isidori I., Lapresa M., Lavenia G., Longhitano L., Lucia B., Luzi G., Mariano S., Marino V., Marrapese G., Martino M., Matocci R., Mazzoni E., Mercuri D., Mirto M., Pignata, S, Scambia, G, Schettino, C, Arenare, L, Pisano, C, Lombardi, D, De Giorgi, U, Andreetta, C, Cinieri, S, De Angelis, C, Priolo, D, Casanova, C, Rosati, M, Greco, F, Zafarana, E, Schiavetto, I, Mammoliti, S, Cecere, S, Salutari, V, Scalone, S, Farolfi, A, Di Napoli, M, Lorusso, D, Gargiulo, P, Califano, D, Russo, D, Spina, A, De Cecio, R, Chiodini, P, Perrone, F, Accinno, V, Altavilla, C, Antonelli, G, Artioli, G, Avola, F, Barbara, B, Barbato, V, Bartoletti, M, Bevilacqua, S, Bordonaro, R, Borghese, O, Buonfanti, G, Camarda, F, Canzanella, G, Carbone, V, Carbone, M, Carlo Stella, G, Cassani, C, Castagna, F, Cattaneo, M, Cinefra, M, Colombo, N, Corsetti, S, Dall'Agata, M, D'Amico, M, Daniele, G, De Marino, E, De Matteis, G, De Placido, S, Del Bene, G, Del Giudice, A, Del Monte, F, Del Sesto, M, Donini, M, Drudi, G, Falcone, G, Favaretto, A, Ferrera, G, Florio, M, Forestieri, V, Gallo, M, Gallo, C, Garibaldi, F, Gerevini, F, Ghizzoni, V, Giganti, M, Gimigliano, A, Giudice, E, Gnocchi, N, Gravina, A, Greggi, S, Iaia, M, Ilardi, A, Iovine, G, Ippoliti, G, Irollo, G, Isidori, I, Lapresa, M, Lavenia, G, Longhitano, L, Lucia, B, Luzi, G, Mariano, S, Marino, V, Marrapese, G, Martino, M, Matocci, R, Mazzoni, E, Mercuri, D, Mirto, M, Pignata S., Scambia G., Schettino C., Arenare L., Pisano C., Lombardi D., De Giorgi U., Andreetta C., Cinieri S., De Angelis C., Priolo D., Casanova C., Rosati M., Greco F., Zafarana E., Schiavetto I., Mammoliti S., Cecere S. C., Salutari V., Scalone S., Farolfi A., Di Napoli M., Lorusso D., Gargiulo P., Califano D., Russo D., Spina A., De Cecio R., Chiodini P., Perrone F., Accinno V., Altavilla C., Antonelli G., Artioli G., Avola F., Barbara B., Barbato V., Bartoletti M., Bevilacqua S., Bordonaro R., Borghese O., Buonfanti G., Camarda F., Canzanella G., Carbone V., Carbone M. R., Carlo Stella G., Cassani C., Castagna F., Cattaneo M., Cinefra M., Colombo N., Corsetti S., Dall'Agata M., D'Amico M., Daniele G., De Marino E., De Matteis G., De Placido S., Del Bene G., Del Giudice A., Del Monte F., Del Sesto M., Donini M., Drudi G., Falcone G., Favaretto A., Ferrera G., Florio M., Forestieri V., Gallo M. S., Gallo C., Garibaldi F., Gerevini F., Ghizzoni V., Giganti M. O., Gimigliano A., Giudice E., Gnocchi N., Gravina A., Greggi S., Iaia M. L., Ilardi A., Iovine G., Ippoliti G., Irollo G., Isidori I., Lapresa M., Lavenia G., Longhitano L., Lucia B., Luzi G., Mariano S., Marino V., Marrapese G., Martino M., Matocci R., Mazzoni E., Mercuri D., and Mirto M.
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- 2023
32. Impact of metformin on the incidence of human cholangiocarcinoma in diabetic patients: A systematic review and meta-analysis
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Laffusa, A, Ciaccio, A, Elvevi, A, Gallo, C, Ratti, L, Invernizzi, P, Massironi, S, Laffusa A., Ciaccio A., Elvevi A., Gallo C., Ratti L., Invernizzi P., Massironi S., Laffusa, A, Ciaccio, A, Elvevi, A, Gallo, C, Ratti, L, Invernizzi, P, Massironi, S, Laffusa A., Ciaccio A., Elvevi A., Gallo C., Ratti L., Invernizzi P., and Massironi S.
- Abstract
Cholangiocarcinoma (CCA) is the second most common liver cancer. Diabetes is a well-known risk factor; however, treatment with metformin has been reported to be protective for several cancers, but data on CCA are still sparse and heterogeneous. We performed this meta-analysis to investigate the role of metformin as a potential protective factor for CCA. In this systematic review and meta-analysis, we searched PubMed/MEDLINE and EMBASE databases, from the date of inception to November 2022, for studies analyzing CCA rate in patients taking metformin. Twenty-nine articles were initially identified, of which four were eligible and included in our systematic review and meta-analysis, from which we estimated the relative risk (RR). The rate of CCA was lower for diabetic patients taking metformin than diabetic patients without metformin intake when comparing two highest quality studies [RR, 0.38; 95% confidence interval (CI), 0.290-0.508; P < 0.001], and three studies with similar inclusion criteria (RR, 0.34; 95% CI, 0.51-0.35; P < 0.001) without significant statistical heterogeneity among them (I2= 29.83%, P = 0,2326 and I2= 35.08%; P = 0.2143, respectively). Our study demonstrated a significant impact of metformin in reducing the risk of CCA by nearly 62-66% in diabetic patients taking metformin.
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- 2023
33. Any Role for Microbiota in Cholangiocarcinoma? A Comprehensive Review
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Elvevi, A, Laffusa, A, Gallo, C, Invernizzi, P, Massironi, S, Elvevi A., Laffusa A., Gallo C., Invernizzi P., Massironi S., Elvevi, A, Laffusa, A, Gallo, C, Invernizzi, P, Massironi, S, Elvevi A., Laffusa A., Gallo C., Invernizzi P., and Massironi S.
- Abstract
Alterations in the human microbiota have been linked to carcinogenesis in several cancers. To date, few studies have addressed the role of the microbiota in cholangiocarcinoma (CCA). Our work aims to update the knowledge about the role of the microbiota in the CCA microenvironment, and to highlight possible novel insights for the development of new diagnostic, prognostic, or even therapeutic strategies. We thus conducted a review of the literature. In recent years, great progress has been made in understanding the pathogenesis, the clinical and histological behavior, and the molecular profile of CCA. Much evidence suggests that the bile microbiota plays an essential role in biliary diseases, including CCA. Some studies have demonstrated that alterations in the qualitative and quantitative composition of the intestinal commensal bacteria lead to overall cancer susceptibility through various pathways. Other studies suggest that the gut microbiota plays a role in the pathogenesis and/or progression of CCA. The clinical implications are far-reaching, and the role of the microbiota in the CCA microenvironment may lead to considering the exciting implications of implementing therapeutic strategies that target the microbiota-immune system axis.
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- 2023
34. Incidence and prevalence of gastric neuroendocrine tumors in patients with chronic atrophic autoimmune gastritis
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Massironi, S, Gallo, C, Elvevi, A, Stegagnini, M, Coltro, L, Invernizzi, P, Massironi S., Gallo C., Elvevi A., Stegagnini M., Coltro L. A., Invernizzi P., Massironi, S, Gallo, C, Elvevi, A, Stegagnini, M, Coltro, L, Invernizzi, P, Massironi S., Gallo C., Elvevi A., Stegagnini M., Coltro L. A., and Invernizzi P.
- Abstract
BACKGROUND The incidence of type I gastric neuroendocrine neoplasms (gNENs) has increased significantly over the past 50 years. Although autoimmune gastritis (AIG) increases the likelihood of developing gNENs, the exact incidence and prevalence of this association remain unclear. AIM To evaluate the incidence and prevalence of type I gNENs in a cohort of patients with a histological diagnosis of AIG. METHODS Patients with a histological diagnosis of AIG were enrolled between October 2020 and May 2022. Circulating levels of CgA and gastrin were assessed at enrollment. Included patients underwent regular endoscopic follow-up to detect gastric neoplastic lesions, enterochromaffin-like (ECL) cell hyperplasia, and the development of gNEN. RESULTS We included 176 patients [142 women (80.7%), median age 64 years, interquartile range (IQR) 53–71 years] diagnosed with AIG between January 1990 and June 2022. At enrollment. One hundred and sixteen patients (65.9%) had ECL hyperplasia, of whom, 29.5% had simple/linear, 30.7% had micronodular, and 5.7% had macronodular type. The median follow-up time was 5 (3–7.5) years. After 1032 person-years, 33 patients developed a total of 50 type I gNENs, with an incidence rate of 0.057 person-years, corresponding to an annual cumulative incidence of 5.7%. Circulating CgA levels did not significantly differ between AIG patients who developed gNENs and those who did not. Conversely, gastrin levels were significantly higher in AIG patients who developed gNENs [median 992 pg/mL IQR = 449–1500 vs 688 pg/mL IQR = 423–1200, P = 0.03]. Calculated gastrin sensitivity and specificity were 90.9% and 1.4%, respectively, with an overall diagnostic accuracy of 30% and a calculated area under the gastrin receiver operating characteristic curve (AUROC or AUC) of 0.53. CONCLUSION Type I gNENs are a significant complication in AIG. Gastrin’s low diagnostic accuracy prevents it from serving as a marker for early diagnosis. Effective strategies for early det
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- 2023
35. Exploring the spectrum of incidental gastric polyps in autoimmune gastritis
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Massironi, S, Elvevi, A, Gallo, C, Laffusa, A, Tortorella, A, Invernizzi, P, Massironi S., Elvevi A., Gallo C., Laffusa A., Tortorella A., Invernizzi P., Massironi, S, Elvevi, A, Gallo, C, Laffusa, A, Tortorella, A, Invernizzi, P, Massironi S., Elvevi A., Gallo C., Laffusa A., Tortorella A., and Invernizzi P.
- Abstract
Background: Gastric polyps represent an abnormal proliferation of the gastric mucosa. Chronic atrophic autoimmune gastritis (CAAG) targets parietal cells and results in hypo-achlorhydria and hypergastrinemia, which exerts a proliferative effect on the gastric mucosa. Aims: We investigate the incidence of gastric polyps in CAAG patients. Methods: This is a single-center retrospective study examining patients with confirmed CAAG from January 1990 until June 2022. Demographic, clinical, biochemical, and serological data were collected for each included patient. The histopathological characteristics of the detected polyps were recorded. Results: A total of 176 CAAG patients were included. Eighty-nine (50.5%) had 163 incidental polyps. Seventy-six patients (85%) had 130 non-endocrine lesions, among which 118 (90.7%) were inflammatory, 6 (4.6%) adenomatous, and 4 (3%) fundic; 33 patients (37%) had gastric neuroendocrine neoplasms (gNENs), and 21 (23.6%) both; one had MALToma and one gastric adenocarcinoma. Higher circulating levels of gastrin and chromogranin A were observed among patients with polyps (median 668 vs 893 pg/ml p = 0.0237, 146 vs 207 ng/ml p = 0.0027, respectively). Conclusion: CAAG implies a high incidence of gNENs and exocrine lesions. Gastrin plays a possible trophic role on the mucosa. Further evidence is needed to validate its predictive role for increased polyp risk in CAAG.
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- 2023
36. P466 Ultrasound muscle assessment for sarcopenia screening in patients with Inflammatory Bowel Disease: A prospective study (SarcUS-IBD)
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Mulinacci, G, primary, Pirola, L, additional, Gandola, D, additional, Ippolito, D, additional, Viganò, C, additional, Laffusa, A, additional, Gallo, C, additional, Invernizzi, P, additional, Danese, S, additional, and Massironi, S, additional
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- 2024
- Full Text
- View/download PDF
37. Galactic Rotation Described with Bulge+Disk Gravitational Models
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Gallo, C. F. and Feng, James Q.
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Astrophysics - Abstract
Observations reveal that mature spiral galaxies consist of stars, gases and plasma approximately distributed in a thin disk of circular shape, usually with a central bulge. The rotation velocities quickly increase from the galactic center and then achieve a constant velocity from the core to the periphery. The basic dynamic behavior of a mature spiral galaxy, such as the Milky Way, is well described by simple models balancing Newtonian gravitational forces against the centrifugal forces associated with a rotating thin axisymmetric disk. In this research, we investigate the effects of adding central bulges to thin disk gravitational models. Even with the addition of substantial central bulges, all the critical essential features of our thin disk gravitational models are preserved. (1) Balancing Newtonian gravitational and centrifugal forces at every point within the disk yields computed radial mass distributions that describe the measured rotation velocity profiles of mature spiral galaxies successfully. (2) There is no need for gravity deviations or ``massive peripheral spherical halos of mysterious Dark Matter''. (3) The calculated total galactic masses are in good agreement with star count data. (4) The addition of central bulges increases the calculated total galactic masses, possibly more consistent with the presence of galactic gases, dust, grains, lumps, planets and plasma in addition to stars. (5) Compared with the light distribution, our mass distributions within the disk are larger out toward the galactic periphery which is cooler with lower opactiy/emissivity (and thus darker). This is apparent from edge-on views of galaxies which display a dark disk-line against a much brighter galactic halo., Comment: 13 Pages Text + 4 Figures
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- 2008
38. Galactic Rotation Described with Various Thin-Disk Gravitational Models
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Feng, James Q. and Gallo, C. F.
- Subjects
Astrophysics - Abstract
For mature spiral galaxies, the rotation velocities quickly increase from the galactic center and achieve a constant velocity from the core to the periphery. This dynamic behavior is described by models balancing Newtonian gravitational and centrifugal forces in rotating thin axisymmetric disks. Freeman's disk assumes a mass density decreasing exponentially with radius which correctly produces rotational velocities which increase from the galactic center to a maximum near the outer core, but then decreases out to the periphery contrary to measurements. Mestel's disk assumes a mass distribution decreasing more slowly (inversely with radius) that yields a constant rotational velocity across the entire disk, but has an unrealistic central mass singularity and does not describe the core rotation properly. Thus combine the Freeman and Mestel disks to utilize their strengths and eliminate their deficiencies. Utilize the Freeman formula for the central core, and the Mestel formula beyond the core to the galactic rim. This combined model produces rotation curves comparable to the measurements of mature spiral galaxies. For a more general thin-disk model, we develop an alternative computational method to solve for the mass density distributions for various measured rotation curves We compute radial mass densities that balance the Newtonian gravitational and centrifugal forces at every point. The computational solutions show mass densities which decrease approximately exponentially in the central core (similar to Freeman), and transition to a slower inverse radial decrease (similar to Mestel) to the periphery. Thus these diverse approaches yield similar results and are mutaully self-consistent with Newtonian gravity/dynamics., Comment: 13 Pages + 8 Figures
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- 2008
39. Galactic Rotation Described with Thin-Disk Gravitational Model
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Feng, James Q. and Gallo, C. F.
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Astrophysics - Abstract
The measured rotation velocity profiles of mature spiral galaxies are successfully described with a gravitational model consisting of a thin axisymmetric disk of finte radius. The disk is assumed uniformly thin but with variable radial mass density. The governing integral equation is based on mechanical balance between Newtonian gravitational and centrifugal forces (due to galaxy rotation) at each and every point in a finite set of concentric rings. The nondimensionalized mathematical system contains a dimensionless parameter we call ``galactic rotation parameter'' which concisely crystallizes perspective. Computational solutions are obtained for the radial mass distributions that satisfy the measured rotational velocity profiles. Together with a constraint equation for mass conservation, the galactic rotational parameter is also determined from which the total galactic mass is calculated from measured galactic radii and maximum rotation velocities. These calculated total galactic masses are in good agreement with data. Our deduced exponentially decreasing mass distributions in the central galactic core are in agreement with almost all others. However our mass distributions differ toward the galactic periphery with more ordinary baryonic mass in these outer disk regions which are cooler with lower opactiy/emissivity (and thus darker)., Comment: 13 pages + 3 figures = 16 pages total
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- 2008
40. Searching Axions through Coupling with Spin: The QUAX Experiment
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Crescini, N., Alesini, D., Braggio, C., Carugno, G., Di Gioacchino, D., Gallo, C. S., Gambardella, U., Gatti, C., Iannone, G., Lamanna, G., Lombardi, A., Ortolan, A., Pengo, R., Ruoso, G., Speake, C. C., Carosi, Gianpaolo, editor, Rybka, Gray, editor, and van Bibber, Karl, editor
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- 2018
- Full Text
- View/download PDF
41. Corrigendum to “Under-reporting of subjective symptoms and its prognostic value: a pooled analysis of 12 cancer clinical trials”: [ESMO Open 9 (2024) 102941]
- Author
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Arenare, L., Di Liello, R., De Placido, P., Gridelli, C., Morabito, A., Pignata, S., Nuzzo, F., Avallone, A., Maiello, E., Gargiulo, P., Schettino, C., Gravina, A., Gallo, C., Chiodini, P., Di Maio, M., Perrone, F., and Piccirillo, M.C.
- Published
- 2024
- Full Text
- View/download PDF
42. Quality-of-life analysis of the MITO-8, MaNGO, BGOG-Ov1, AGO-Ovar2.16, ENGOT-Ov1, GCIG study comparing platinum-based versus non-platinum-based chemotherapy in patients with partially platinum-sensitive recurrent ovarian cancer
- Author
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Piccirillo, M.C., Scambia, G., Bologna, A., Signoriello, S., Vergote, I., Baumann, K., Lorusso, D., Murgia, V., Sorio, R., Ferrandina, G., Sacco, C., Cormio, G., Breda, E., Cinieri, S., Natale, D., Mangili, G., Pisano, C., Cecere, S.C., Di Napoli, M., Salutari, V., Raspagliesi, F., Arenare, L., Bergamini, A., Bryce, J., Daniele, G., Gallo, C., Pignata, S., and Perrone, F.
- Published
- 2018
- Full Text
- View/download PDF
43. Analysis of Gene Expression Discretization Techniques in Microarray Biclustering
- Author
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Dussaut, J. S., Gallo, C. A., Carballido, J. A., Ponzoni, I., Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Rojas, Ignacio, editor, and Ortuño, Francisco, editor
- Published
- 2017
- Full Text
- View/download PDF
44. Effect of season, supplementation and fasting on glycolytic potential and activity of AMP-activated protein kinase, glycogen phosphorylase and glycogen debranching enzyme in grass-fed steers as determined in Longissimus lumborum muscle
- Author
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Apaoblaza, A., Strobel, P., Ramírez-Reveco, A., Jeréz-Timaure, N., Monti, G., and Gallo, C.
- Published
- 2017
- Full Text
- View/download PDF
45. CO2-Vadose and DEMO-CO2 Projects: Two Complementary Projects about Geochemical and Geophysical Monitoring During CO2 Leakage
- Author
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Garcia, B., Rhino, K., Loisy, C., Le Roux, O., Cerepi, A., Rouchon, V., Noirez, S., Le Gallo, C., Delaplace, Ph., Willequet, O., and Bertrand, C.
- Published
- 2017
- Full Text
- View/download PDF
46. Anti TNF como Inductor de Lupus Cutáneo. Caso Clínico
- Author
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GALLO, C., primary, RAMÍREZ, L., additional, RAMOS, G., additional, SEPÚLVEDA, D., additional, POZO, P., additional, CÁCERES, N., additional, VIZCARRA, G., additional, FUENTEALBA, C., additional, GODOY, M., additional, and PACHECO, D., additional
- Published
- 2023
- Full Text
- View/download PDF
47. P-640 No impact of Progestin Primed Ovarian Stimulation (PPOS) on euploid blastocyst rate per cohort of metaphase-II oocytes during PGT-A cycles: a case-control study
- Author
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Rania, E, primary, Vaiarelli, A, additional, Cimadomo, D, additional, Pittana, E, additional, Gallo, C, additional, Fiorenza, A, additional, Alfano, S, additional, D'Alessandro, P, additional, Golino, D, additional, Sansone, A, additional, Trabucco, E, additional, Rienzi, L, additional, Ubaldi, F M, additional, and Venturella, R, additional
- Published
- 2023
- Full Text
- View/download PDF
48. Acute kidney injury during colistin therapy: a prospective study in patients with extensively-drug resistant Acinetobacter baumannii infections
- Author
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Durante-Mangoni, E., Andini, R., Signoriello, S., Cavezza, G., Murino, P., Buono, S., De Cristofaro, M., Taglialatela, C., Bassetti, M., Malacarne, P., Petrosillo, N., Corcione, A., Viscoli, C., Utili, R., and Gallo, C.
- Published
- 2016
- Full Text
- View/download PDF
49. The association of financial difficulties with clinical outcomes in cancer patients: secondary analysis of 16 academic prospective clinical trials conducted in Italy
- Author
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Perrone, F., Jommi, C., Di Maio, M., Gimigliano, A., Gridelli, C., Pignata, S., Ciardiello, F., Nuzzo, F., de Matteis, A., Del Mastro, L., Bryce, J., Daniele, G., Morabito, A., Piccirillo, M.C., Rocco, G., Guizzaro, L., and Gallo, C.
- Published
- 2016
- Full Text
- View/download PDF
50. Rectal neuroendocrine tumors: Current advances in management, treatment, and surveillance
- Author
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Gallo, C, Invernizzi, P, Massironi, S, Rossi, R, Cavalcoli, F, Barbaro, F, Boskoski, I, Gallo C., Invernizzi P., Massironi S., Rossi R. E., Cavalcoli F., Barbaro F., Boskoski I., Gallo, C, Invernizzi, P, Massironi, S, Rossi, R, Cavalcoli, F, Barbaro, F, Boskoski, I, Gallo C., Invernizzi P., Massironi S., Rossi R. E., Cavalcoli F., Barbaro F., and Boskoski I.
- Abstract
Rectal neuroendocrine neoplasms (r-NENs) are considered among the most frequent digestive NENs, together with small bowel NENs. Their incidence has increased over the past few years, and this is probably due to the widespread use of endoscopic screening for colorectal cancer and the advanced endoscopic procedures available nowadays. According to the current European Neuroendocrine Tumor Society (ENETS) guidelines, well-differentiated r-NENs smaller than 10 mm should be endoscopically removed in view of their low risk of local and distant invasion. R-NENs larger than 20 mm are candidates for surgical resection because of their high risk of distant spreading and the involvement of the muscularis propria. There is an area of uncertainty regarding tumors between 10 and 20 mm, in which the metastatic risk is intermediate and the endoscopic treatment can be challenging. Once removed, the indications for surveillance are scarce and poorly codified by international guidelines, therefore in this paper, a possible algorithm is proposed.
- Published
- 2022
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