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1. EVALUATION OF FERTILITY IN WOMEN TREATED WITH THE R‐DA‐EPOCH REGIMEN FOR PRIMARY MEDIASTINAL B CELL LYMPHOMA (PMBCL)

Author

Georgopoulou, A. N., primary, Vassilakopoulos, T. P., additional, Kalantaridou, S., additional, Georgopoulos, N. A., additional, Lalou, E., additional, Panayiotidis, P., additional, Siakantaris, M., additional, Konstantinou, I., additional, Galopoulos, D., additional, Belia, M., additional, Piperidou, A., additional, and Angelopoulou, M. K., additional

Published
2023
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2. P1085: EVALUATION OF GONADAL FUNCTION IN YOUNG WOMEN DIAGNOSED WITH HODGKIN AND NON-HODGKIN LYMPHOMA

Author

Georgopoulou, A. N., primary, Giannakou, A., additional, Vassilakopoulos, T. P., additional, Siakantaris, M., additional, Georgopoulos, N. A., additional, Kalantaridou, S., additional, Lalou, E., additional, Keramaris, K., additional, Loukari, E., additional, Arapaki, M., additional, Konstantinou, I., additional, Machairas, A., additional, Kopsaftopoulou, A., additional, Mammali, I., additional, Vassilopoulos, I., additional, Galopoulos, D., additional, and Angelopoulou, M. K., additional

Published
2022
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3. Hematology-Cell Morphology -- Case 16.

Author

Asimakopoulos, J. V., Papageorgiou, L., Drandakis, J., Vasilopoulos, I., Galopoulos, D., Kopsaftopoulou, A., Piperidou, A., Machairas, A., Georgopoulou, A., Karapaschalidis, A., Lefaki, M. A., Liaskas, A., Zerzi, C., Sinni, E., Plata, E., Tsaftaridis, P., Siakantaris, M. P., Vassilakopoulos, T. P., Angelopoulou, M. K., and Meletis, J.

Subjects
MORPHOLOGY, BONE marrow cells, EPSTEIN-Barr virus diseases
Published
2022

4. Hematology-Cell Morphology - Case 20.

Author

Asimakopoulos, J. V., Papageorgiou, L., Drandakis, J., Vasilopoulos, I., Galopoulos, D., Kopsaftopoulou, A., Piperidou, A., Machairas, A., Georgopoulou, A., Karapaschalidis, A., Lefaki, M. A., Liaskas, Î'., Zerzi, C., Sinni, E., Plata, E., Tsaftaridis, P., Siakantaris, M. P., Vassilakopoulos, T. P., Angelopoulou, M. K., and Meletis, J.

Subjects
MORPHOLOGY, BONE marrow cells
Published
2023

5. Hematology-Cell Morphology - Case 19.

Author

Asimakopoulos, J. V., Papageorgiou, L., Drandakis, J., Vasilopoulos, I., Galopoulos, D., Kopsaftopoulou, A., Piperidou, A., Machairas, A., Georgopoulou, A., Karapaschalidis, A., Lefaki, M. A., Liaskas, Î'., Zerzi, C., Sinni, E., Plata, E., Tsaftaridis, P., Siakantaris, M. P., Vassilakopoulos, T. P., Angelopoulou, M. K., and Meletis, J.

Subjects
MORPHOLOGY, BONE marrow cells
Published
2023

6. Hematology-Cell Morphology - Case 10.

Author

Asimakopoulos, J. V., Papageorgiou, L., Arapaki, P. M., Chatzidimitriou, C., Belia, M., Konstantinou, E., Galopoulos, D., Drandakis, J., Machairas, A., Kopsaftopoulou, A., Georgopoulou, A., Karapaschalidis, A., Vasilopoulos, I., Piperidou, A., Panitsas, F., Benekou, K., Sinni, E., Siakantaris, M. P., Tsaftaridis, P., and Plata, E.

Subjects
MORPHOLOGY, BONE marrow transplantation
Published
2021

7. Hematology-Cell Morphology -- Case 9.

Author

Asimakopoulos, J. V., Papageorgiou, L., Arapaki, P. M., Chatzidimitriou, C., Belia, M., Konstantinou, E., Galopoulos, D., Drandakis, J., Machairas, A., Kopsaftopoulou, A., Georgopoulou, A., Karapaschalidis, A., Vasilopoulos, I., Piperidou, A., Panitsas, F., Benekou, K., Sinni, E., Siakantaris, M. P., Tsaftaridis, P., and Plata, E.

Subjects
MORPHOLOGY, B cells, CELL size, T cells, LYMPHOID tissue
Published
2021

8. Hematology-Cell Morphology - Case 5.

Author

Asimakopoulos, J. V., Papageorgiou, L., Arapaki, P. M., Chatzidimitriou, C., Belia, M., Triantafyllou, E. F., Konstantinou, E., Efstathopoulou, M., Galopoulos, D., Drandakis, J., Machairas, A., Kopsaftopoulou, A., Panitsas, F., Benekou, K., Sinni, E., Siakantaris, M. P., Tsaftaridis, P., Plata, E., Vassilakopoulos, T. P., and Angelopoulou, M. K.

Subjects
MORPHOLOGY, BONE marrow cells, BONE marrow transplantation
Published
2020

9. Hematology-Cell Morphology - Case 3.

Author

Asimakopoulos, J. V., Papageorgiou, L., Chatzidimitriou, C., Arapaki, P. M., Belia, M., Triantafyllou, E. F., Konstantinou, E., Efstathopoulou, M., Galopoulos, D., Pliakou, E., Drandakis, J., Machairas, A., Kopsaftopoulou, A., Benekou, K., Sinni, E., Tsaftaridis, P., Plata, E., Vassilakopoulos, T. P., Angelopoulou, M. K., and Konstantopoulos, K.

Subjects
MORPHOLOGY, BONE marrow transplantation
Published
2020

10. Hematology-Cell Morphology – Case 2.

Author

Asimakopoulos, J. V., Papageorgiou, L., Chatzidimitriou, C., Arapaki, P. M., Belia, M., Triantafyllou, E. F., Konstantinou, E., Efstathopoulou, M., Galopoulos, D., Pliakou, E., Drandakis, J., Machairas, A., Benekou, K., Sinni, E., Tsaftaridis, P., Plata, E., Vassilakopoulos, T. P., Angelopoulou, M. K., Konstantopoulos, K., and Meletis, J.

Subjects
MORPHOLOGY, GOLGI apparatus, BONE marrow cells, BONE marrow transplantation
Published
2019

11. Hematology Quiz - Case 60.

Author

Asimakopoulos, J. V., Vasilopoulos, I., Papageorgiou, L., Konstantinou, E., Galopoulos, D., Arapaki, M. P., Chatzidimitriou, C., Belia, M., Machairas, A., Drandakis, J., Kopsaftopoulou, A., Piperidou, A., Georgopoulou, A., Karapaschalidis, A., Alexandropoulos, A., Lefaki, M. A., Petsa, P., Panitsas, F., Benekou, K., and Sinni, E.

Subjects
HEMATOLOGY, PHYSICIANS, MEDICAL societies, BLOOD cell count, DIAGNOSIS, LYMPHADENITIS, TASTE disorders
Published
2021

12. Hematology-Cell Morphology - Case 8.

Author

Asimakopoulos, J. V., Papageorgiou, L., Arapaki, P. M., Chatzidimitriou, C., Belia, M., Konstantinou, E., Galopoulos, D., Drandakis, J., Machairas, A., Kopsaftopoulou, A., Georgopoulou, A., Karapaschalidis, A., Vasilopoulos, I., Piperidou, A., Panitsas, F., Benekou, K., Sinni, E., Siakantaris, M. P., Tsaftaridis, P., and Plata, E.

Subjects
MORPHOLOGY, PERIPHERAL circulation, CONTINUING medical education, BLOOD circulation, BONE marrow transplantation
Published
2020

13. Hematology-Cell Morphology – Case 7.

Author

Asimakopoulos, J. V., Papageorgiou, L., Arapaki, P. M., Chatzidimitriou, C., Belia, M., Konstantinou, E., Galopoulos, D., Drandakis, J., Machairas, A., Kopsaftopoulou, A., Georgopoulou, A., Karapaschalidis, A., Vassilopoulos, I., Piperidou, A., Panitsas, F., Benekou, K., Sinni, E., Siakantaris, M. P., Tsaftaridis, P., and Plata, E.

Subjects
MORPHOLOGY, BONE marrow cells, CONTINUING medical education, BONE marrow transplantation
Published
2020

14. Hematology-Cell Morphology -- Case 6.

Author

Asimakopoulos, J. V., Papageorgiou, L., Arapaki, P. M., Chatzidimitriou, C., Belia, M., Triantafyllou, E. F., Konstantinou, E., Efstathopoulou, M., Galopoulos, D., Drandakis, J., Machairas, A., Kopsaftopoulou, A., Panitsas, F., Benekou, K., Sinni, E., Siakantaris, M. P., Tsaftaridis, P., Plata, E., Vassilakopoulos, T. P., and Angelopoulou, M. K.

Subjects
MORPHOLOGY, CONTINUING medical education, BONE marrow transplantation
Published
2020

15. Hematology-Cell Morphology − Case 1.

Author

Asimakopoulos, J. V., Papageorgiou, L., Chatzidimitriou, C., Arapaki, P. M., Belia, M., Triantafyllou, E. F., Konstantinou, E., Efstathopoulou, M., Galopoulos, D., Pliakou, E., Drandakis, J., Sinni, E., Tsaftaridis, P., Plata, E., Vassilakopoulos, T. P., Angelopoulou, M. K., Konstantopoulos, K., and Meletis, J.

Subjects
MORPHOLOGY, MEDICAL societies, BONE marrow transplantation
Published
2019

16. Hematology-cell morphology – case 3

Author

Asimakopoulos, J. V., Papageorgiou, L., Arapaki, P. M., Chatzidimitriou, C., Belia, M., Triantafyllou, E. F., Konstantinou, E., Efstathopoulou, M., Galopoulos, D., Pliakou, E., Drandakis, J., Machairas, A., Kopsaftopoulou, A., Benekou, K., Panitsas, F., Sinni, E., Marina Siakantaris, Tsaftaridis, P., Plata, E., Vassilakopoulos, T. P., Angelopoulou, M. K., Konstantopoulos, K., and Meletis, J.

17. Hematology-cell morphology – case 7

Author

Asimakopoulos, J. V., Papageorgiou, L., Arapaki, P. M., Chatzidimitriou, C., Belia, M., Konstantinou, E., Galopoulos, D., Drandakis, J., Machairas, A., Kopsaftopoulou, A., Georgopoulou, A., Karapaschalidis, A., Vassilopoulos, I., Piperidou, A., Panitsas, F., Benekou, K., Sinni, E., Marina Siakantaris, Tsaftaridis, P., Plata, E., Vassilakopoulos, T. P., Angelopoulou, M. K., Konstantopoulos, K., and Meletis, J.

18. Hematology-cell morphology – case 5

Author

Asimakopoulos, J. V., Papageorgiou, L., Arapaki, P. M., Chatzidimitriou, C., Belia, M., Triantafyllou, E. F., Konstantinou, E., Efstathopoulou, M., Galopoulos, D., Drandakis, J., Machairas, A., Kopsaftopoulou, A., Panitsas, F., Benekou, K., Sinni, E., Marina Siakantaris, Tsaftaridis, P., Plata, E., Vassilakopoulos, T. P., Angelopoulou, M. K., Konstantopoulos, K., and Meletis, J.

19. Hematology-cell morphology – case 6

Author

Asimakopoulos, J. V., Papageorgiou, L., Arapaki, P. M., Chatzidimitriou, C., Belia, M., Triantafyllou, E. F., Konstantinou, E., Efstathopoulou, M., Galopoulos, D., Drandakis, J., Machairas, A., Kopsaftopoulou, A., Panitsas, F., Benekou, K., Sinni, E., Marina Siakantaris, Tsaftaridis, P., Plata, E., Vassilakopoulos, T. P., Angelopoulou, M. K., Konstantopoulos, K., and Meletis, J.

20. Monitoring Humoral Response Following BNT162b2 mRNA Vaccination against SARS-CoV-2 in Hematopoietic Stem-Cell Transplantation Patients: A Single-Center Prospective Study along with a Brief Review of Current Literature.

Author

Asimakopoulos JV, Lalou E, Seferlis G, Malliarou M, Konstantinou E, Drandakis I, Vasilopoulos I, Georgopoulou AN, Kopsaftopoulou A, Machairas A, Piperidou A, Karapaschalidis A, Lefaki ME, Galopoulos D, Arapaki MP, Petsa P, Benekou E, Siakantaris MP, Papavassiliou AG, Tsaftaridis P, Panayiotidis P, Vassilakopoulos TP, Papapanagiotou A, and Angelopoulou MK

Abstract

Data on antibody response (AR) after vaccination against SARS-CoV2 in hematopoietic stem-cell transplantation setting (HSCT) were initially scarce, mainly due to the exclusion of such patients from approval studies. Shortly after the worldwide application of vaccination against SARS-CoV-2 in vulnerable populations such as patients with hematologic malignancies, limited single-center trials, including HSCT patients, were published. However, there was a great heterogeneity between them regarding the type of underlying malignancy, co-current treatment, type of vaccine, method of AR measurement, and time point of AR measurement. Herein, we present the results of a prospective study on AR after vaccination for SARS-CoV-2 using the BNT162b2 vaccine in a cohort of 54 HSCT recipients-mostly autologous from a single Unit-along with a broad review of the current literature. In our cohort, the AR positivity rate at 1 month was 80.8% and remained positive in 85.7% of patients at 3 months after vaccination. There were only nine non-responders, who were more heavily pretreated and more frequently hypogammaglobulinemic compared to responders. High antibody titers (AT), [AT ≥ 1000 U/mL], were detected in 38.5% and 30.6% of the patients at m 1 and m 3 , respectively. A significant decline in AT between m 1 and m 3 was demonstrated- p < 0.0001; median AT 1 and AT 3 were 480.5 and 293 U/mL, respectively. A novel finding of our study was the negative impact of IgA hypogammaglobulinemia on response to vaccination. Other negative significant factors were treatment with anti-CD20 antibody at vaccination and vaccination within 18 months from HSCT. Our data indicate that HSCT recipients elicit a positive response to the BNT162b2 vaccine against SARS-CoV-2 when vaccinated at 6 months post-transplant, and vaccination should be offered to this patient population even within the post-pandemic COVID-19 era.

Published
2024
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21. Serum ferritin levels in previously untreated classical Hodgkin lymphoma: correlations and prognostic significance.

Author

Karakatsanis S, Panitsas F, Arapaki M, Galopoulos D, Asimakopoulos JV, Liaskas A, Chatzidimitriou C, Belia M, Konstantinou E, Vassilopoulos I, Papadatos SS, Sachanas S, Efstathopoulou M, Yiakoumis X, Pardalis V, Iliakis T, Giannakopoulou N, Dimou M, Chatzidavid S, Boutsikas G, Petevi K, Kanellopoulos A, Gainaru G, Variamis E, Siakantaris MP, Kyrtsonis MC, Plata E, Tsaftaridis P, Dimopoulou MN, Viniou NA, Syrigos KN, Pangalis GA, Panayiotidis P, Konstantopoulos K, Angelopoulou MK, and Vassilakopoulos TP

Subjects
Biomarkers, Ferritins, Humans, Male, Prognosis, Progression-Free Survival, Retrospective Studies, Hodgkin Disease diagnosis, Hodgkin Disease therapy
Abstract

Serum ferritin (SF) is frequently elevated in classical Hodgkin lymphoma (cHL). We report on its prognostic significance in an unselected series of 529 cHL patients treated with state-of-the-art therapy. Higher baseline levels correlated with markers of advanced/aggressive disease. SF levels were significantly higher in male and older patients, those with high body mass index and mixed cellularity histology. The strongest correlation was recorded between SF and complement reactive protein (CRP) levels. Gender-specific SF cutoffs which provided the best discrimination in terms of freedom from progression (FFP) were identified. In multivariate analysis elevated SF levels, advanced stage and high lactate dehydrogenase (LDH) were independent prognostic factors of inferior FFP. SF also appears to retain independent prognostic significance for progression-free survival (PFS) but not for overall survival (OS). In conclusion, SF levels in cHL reflect disease activity and are associated with adverse patient outcomes.

Published
2022
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22. Progressive Multifocal Leukoencephalopathy Following Treatment With Obinutuzumab in a Patient With Non-Hodgkin Follicular Lymphoma: A Case Report.

Author

Diavati S, Asimakopoulos JV, Galopoulos D, Konstantinou I, Argyrakos T, Toulas P, Vassilakopoulos TP, Konstantopoulos K, and Angelopoulou MK

Subjects
Aged, Brain diagnostic imaging, Brain pathology, DNA, Viral isolation & purification, Fatal Outcome, Female, Humans, Immunocompromised Host, JC Virus genetics, JC Virus immunology, JC Virus isolation & purification, Leukoencephalopathy, Progressive Multifocal blood, Leukoencephalopathy, Progressive Multifocal chemically induced, Leukoencephalopathy, Progressive Multifocal immunology, Lymphoma, Follicular immunology, Magnetic Resonance Imaging, Neoplasm Recurrence, Local immunology, Antibodies, Monoclonal, Humanized adverse effects, Antineoplastic Agents, Immunological adverse effects, Leukoencephalopathy, Progressive Multifocal diagnosis, Lymphoma, Follicular drug therapy, Neoplasm Recurrence, Local drug therapy
Published
2021
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23. Patient Survival After Acute Voluntary Poisoning With a Huge Dose of Oxcarbazepine and Olanzapine.

Author

Kalogera V, Galopoulos D, Eleftheriotis G, Meimeti E, Malios I, Marathonitis G, and Loupa C

Subjects
Antipsychotic Agents poisoning, Antipsychotic Agents therapeutic use, Female, Greece, Humans, Middle Aged, Poisoning diagnosis, Treatment Outcome, Bipolar Disorder drug therapy, Olanzapine poisoning, Olanzapine therapeutic use, Oxcarbazepine poisoning, Oxcarbazepine therapeutic use, Poisoning physiopathology, Poisoning therapy
Abstract

Introduction: Oxcarbazepine is a carbamazepine pre-drug with less drug interactions. Its adverse effects, including hyponatremia, somnolence and ataxia, are dose dependent. Olanzapine is an atypical antipsychotic drug most commonly used to manage psychoses and symptoms of irritability and aggressive behavior. Main side effects include extrapyramidal and anticholinergic symptoms, weight gain, and hyperglycemia., Case Report: In this manuscript a case of oxcarbazepine and olanzapine intoxication is discussed. A 45-year-old woman, previously diagnosed with bipolar disorder and chronic alcoholism, was presented two hours after ingestion of 30,000mg of oxcarbazepine and 140 mg of olanzapine, combined with alcohol. She was immediately treated with gastric lavage and administration of activated charcoal. During her hospitalization she was hemodynamically and respiratory stable with no neurological signs and symptoms except for somnolence. Another side effect was hyponatremia. She was discharged from our department in stable clinical condition after being evaluated by a psychiatrist., Conclusion: Early approach is crucial for the management of drug intoxication. Late symptoms can be avoided through close monitoring of vital signs, mental status and laboratory values. Psychiatric consultation is essential for a better long-term outcome.

Published
2018
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