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1. DIMG92 : un simulateur de formation pour le procédé DIMERSOL Dimg92: a Training Simulator for the Dimersol Process

Author

Nica A., Capelle M., and Galtier F.

Subjects
Chemical technology, TP1-1185, Energy industries. Energy policy. Fuel trade, HD9502-9502.5
Abstract

DIMG92 est un simulateur de formation sur le procédé pétrochimique DIMERSOL (procédé IFP de dimérisation du propylène). En simulant le réacteur et ses équipements annexes, les opérateurs s'exercent à conduire l'unité et comprennent les effets des divers paramètres à prendre en compte. Le simulateur est composé de deux logiciels : - Un logiciel de modélisation, basé sur la représentation mathématique de connaissances physico-chimiques et physiques. Aucun empirisme n'est utilisé dans le modèle. Ce logiciel a été développé par l'Institut Français du Pétrole (IFP). - Un logiciel d'environnement de simulation dynamique pour la formation. Ce logiciel à interface graphique et interactive est distribué par la société française Réalisation en Systémique Industrielle (RSI). Industrial units are tending to become more and more complex and are characterized by a very high degree of integration. The operating of such units requires highly skilled operators. This is why dynamic simulators have training as their prime goal. The DIMG92 simulator falls within this category. It simulates the reaction section of the DIMERSOL G process in a steady state or not. The DIMERSOL G process is designed for the dimerization of propylene into hexene. In the modeled unit, the reaction section includes a liquid-phase reactor and a pump-around on which a heat exchanger is installed. The heat exchanger, which uses water as the cooling fluid, evacuates the heat of reaction. The reaction temperature is between 45 and 55°C. The reactor pressure is in the vicinity of 22 effective bars. The catalyst is in a liquid state. A standard feedstock is made up of 30 weight % inert matter and 70% propylene. Modeling is broken down into three parts : the kinetics, the reactor, the heat exchanger. Mathematical modeling of the oligomerization kinetics was performed at Institut Français du Pétrole (IFP) in 1987. By taking into consideration the initiation, prolongation and termination reactions starting with propylene and hexene, we can understand the oligomerization kinetics in the DIMERSOL G process. The deactivation of the catalyst is represented by a first-order kinetics. With a reduced number of constants, the model takes the following aspects into consideration :(a) The production of heavy oligomers (no propagation reaction is neglected). (b) The formation of oligomers combined with the catalyst. (c) The deactivation of the catalyst in time and the temperature. The kinetic constants and activation energies were determined so that the model can restore the different kinetic results of pilot tests. The modeling of the reactor considers that this reactor is perfectly stirred and always full of liquid. The principal equations reflect the balances of the molecular species. There are also molar balances for the olefins, for the olefins combined with the catalyst, for the inert matter, for the active catalyst and for the deactivated catalyst. An overall mass balance and a mass balance for the sum of olefinic species are added on. A heat balance is used to predict the temperature of the reactor. Other calculations are performed to obtain the selectivities, the conversion and the outflow of each constituent. The modeling of the heat exchanger is done by a static model. The outlet temperatures of the fluids and the power of the heat exchanger are calculated by making an estimate of the efficiency of the heat exchanger. The programming of the model is modular. This makes for a standardized and coherent whole. The modules are written in FORTRAN 77. The user has access either to a static solution to find a stable operating point or dynamic calculating during which the console operator can introduce various disturbances in the variables of the process. In the static module the balances for the reactor form a system of nonlinear algebraic equations that is solved by a Newton-Raphson algorithm. The dynamic module mainly includes the integration, in relation to the processing time of the system of differential equations for the balances relative to the reactor. The above two modules make use of various joint subroutines. The modules containing the modeling of the reaction section are integrated in the SORYA-MX application. This application is a graphic and interactive interface designed for training simulators. SORYA-MX is distributed by the French company Réalisation en Systémique Industrielle(RSI). SORYA-MX has a time management system capable of controlling the accelaration of the simulation at will. It is a multitask application. SORYA-MX has two levels of use :(1 ) A designerlevel for configuring the simulator by creating, for example, mimic diagrams, alarm levels, operating data sheets, controllers, disturbance scenarios, etc. (2) A userlevel for activating the functionalities defined by the designer level, for controlling the controllers, for safeguarding, etc. As the result of this environment, learning on the simulator is much like operating the unit via a centralized control system. This type of simulator has already shown proof of its effectiveness :(a) At the level of research, as a working support for the designing of expert systems or for designing advanced controls. (b) At the level of training, for operators of units operating under an IFP process license. By a fairly fine kinetic model for oligomerization and careful programming, the model thus developed can be used as a basis for other studies. In the future, it seems desirable to : (a) Increase the degree of modeling (reactors in cascade, modeling of impurities and of start-up). (b) Extend modeling to similar processes. Nevertheless, for pursuing this project it is absolutely necessary to arouse greater interest among customers during the selling of processes for this training tool and among process engineers on the spot for obtaining a better understanding of internal phenomena.

Published
2006
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5. Safety and efficacy of inactivated varicella zoster virus vaccine in immunocompromised patients with malignancies: a two-arm, randomised, double-blind, phase 3 trial

Author

Cerana, S, Dictar, MO, Bonvehi, P, Tregnaghi, JP, Fein, L, Ashley, D, Singh, M, Hayes, T, Playford, G, Morrissey, O, Thaler, J, Kuehr, T, Greil, R, Pecherstorfer, M, Duck, L, Van Eygen, K, Aoun, M, De Prijck, B, Franke, FA, Barrios, CHE, Mendes, AVA, Serrano, SV, Garcia, RF, Moore, F, Camargo, JFC, Pires, LA, Alves, RS, Radinov, A, Oreshkov, K, Minchev, V, Hubenova, AI, Koynova, T, Ivanov, I, Rabotilova, B, Petrov, PA, Chilingirov, P, Karanikolov, S, Raynov, J, Grimard, D, McNeil, S, Kumar, D, Larratt, LM, Weiss, K, Delage, R, Diaz-Mitoma, FJ, Cano, PO, Couture, F, Carvajal, P, Yepes, A, Torres Ulloa, R, Fardella, P, Caglevic, C, Rojas, C, Orellana, E, Gonzalez, P, Acevedo, A, Galvez, KM, Gonzalez, ME, Franco, S, Restrepo, JG, Rojas, CA, Bonilla, C, Florez, LE, Ospina, AV, Manneh, R, Zorica, R, Vrdoljak, DV, Samarzija, M, Petruzelka, L, Vydra, J, Mayer, J, Cibula, D, Prausova, J, Paulson, G, Ontaneda, M, Palk, K, Vahlberg, A, Rooneem, R, Galtier, F, Postil, D, Lucht, F, Laine, F, Launay, O, Laurichesse, H, Duval, X, Cornely, OA, Camerer, B, Panse, J, Zaiss, M, Derigs, H-G, Menzel, H, Verbeek, M, Georgoulias, V, Mavroudis, D, Anagnostopoulos, A, Terpos, E, Cortes, D, Umanzor, J, Bejarano, S, Galeano, RW, Wong, RSM, Hui, P, Pedrazzoli, P, Ruggeri, L, Aversa, F, Bosi, A, Gentile, G, Rambaldi, A, Contu, A, Marei, L, Abbadi, A, Hayajneh, W, Kattan, J, Farhat, F, Chahine, G, Rutkauskiene, J, Marfil Rivera, LJ, Lopez Chuken, YA, Franco Villarreal, H, Lopez Hernandez, J, Blacklock, H, Lopez, RI, Alvarez, R, Gomez, AM, Quintana, TS, Moreno Larrea, MDC, Zorrilla, SJ, Alarcon, E, Samanez, FCA, Caguioa, PB, Tiangco, BJ, Mora, EM, Betancourt-Garcia, RD, Hallman-Navarro, D, Feliciano-Lopez, LJ, Velez-Cortes, HA, Cabanillas, F, Ganea, DE, Ciuleanu, TE, Ghizdavescu, DG, Miron, L, Cebotaru, CL, Cainap, CI, Anghel, R, Dvorkin, MV, Gladkov, OA, Fadeeva, NV, Kuzmin, AA, Lipatov, ON, Zbarskaya, II, Akhmetzyanov, FS, Litvinov, IV, Afanasyev, BV, Cherenkova, M, Lioznov, D, Lisukov, IA, Smirnova, YA, Kolomietz, S, Halawani, H, Goh, YT, Drgona, L, Chudej, J, Matejkova, M, Reckova, M, Rapoport, BL, Szpak, WM, Malan, DR, Jonas, N, Jung, CW, Lee, DG, Yoon, SS, Lopez Jimenez, J, Duran Martinez, I, Rodriguez Moreno, JF, Solano Vercet, C, de la Camara, R, Batlle Massana, M, Yeh, S-P, Chen, C-Y, Chou, H-H, Tsai, C-M, Chiu, C-H, Siritanaratkul, N, Norasetthada, L, Sriuranpong, V, Seetalarom, K, Akan, H, Dane, F, Ozcan, MA, Ozsan, GH, Kalayoglu Besisik, SF, Cagatay, A, Yalcin, S, Peniket, A, Mullan, SR, Dakhil, KM, Sivarajan, K, Suh, JJ-G, Sehgal, A, Marquez, F, Gomez, EG, Mullane, MR, Skinner, WL, Behrens, RJ, Trevarthe, DR, Mazurczak, MA, Lambiase, EA, Vidal, CA, Anac, SY, Rodrigues, GA, Baltz, B, Boccia, R, Wertheim, MS, Holladay, CS, Zenk, D, Fusselman, W, Wade III, JL, Jaslowsk, AJ, Keegan, J, Robinson, MO, Go, RS, Farnen, J, Amin, B, Jurgens, D, Risi, GF, Jr, Beatty, PG, Naqvi, T, Parshad, S, Hansen, VL, Ahmed, M, Steen, PD, Badarinath, S, Dekker, A, Scouros, MA, Young, DE, Graydon Harker, W, Kendall, SD, Citron, ML, Chedid, S, Posada, JG, Jr, Gupta, MK, Rafiyath, S, Buechler-Price, J, Sreenivasappa, S, Chay, CH, Burke, JM, Young, SE, Mahmood, A, Kugler, JW, Gerstner, G, Fuloria, J, Belman, ND, Geller, R, Nieva, J, Whittenberger, BP, Wong, BMY, Cescon, TP, Abesada-Terk, G, Jr, Guarino, MJ, Zweibach, A, Ibrahim, EN, Takahashi, G, Garrison, MA, Mowat, RB, Choi, BS, Oliff, IA, Singh, J, Guter, KA, Ayrons, K, Rowland, KM, Noga, SJ, Rao, SB, Columbie, A, Nualart, MT, Cecchi, GR, Campos, LT, Mohebtash, M, Flores, MR, Rothstein-Rubin, R, O'Connor, BM, Soori, G, Knapp, M, Miranda, FG, Goodgame, BW, Kassem, M, Belani, R, Sharma, S, Ortiz, T, Sonneborn, HL, Markowitz, AB, Wilbur, D, Meiri, E, Koo, VS, Jhangiani, HS, Wong, L, Sanani, S, Lawrence, SJ, Jones, CM, Murray, C, Papageorgiou, C, Gurtler, JS, Ascensao, JL, Venigalla, ML, D'Andrea, M, De Las Casas, C, Haile, DJ, Qazi, FU, Santander, JL, Thomas, MR, Rao, VP, Craig, M, Garg, RJ, Robles, R, Lyons, RM, Stegemoller, RK, Goel, S, Garg, S, Lowry, P, Lynch, C, Lash, B, Repka, T, Baker, J, Goueli, BS, Campbell, TC, Van Echo, DA, Lee, YJ, Reyes, EA, Senecal, FM, Donnelly, G, Byeff, P, Weiss, R, Reid, T, Roeland, E, Goel, A, Prow, DM, Brandt, DS, Kaplan, HG, Payne, JE, Boeckh, MG, Rosen, PJ, Mena, RR, Khan, R, Betts, RF, Sharp, SA, Morrison, VA, Fitz-Patrick, D, Congdon, J, Erickson, N, Abbasi, R, Henderson, S, Mehdi, A, Wos, EJ, Rehmus, E, Beltzer, L, Tamayo, RA, Mahmood, T, Reboli, AC, Moore, A, Brown, JM, Cruz, J, Quick, DP, Potz, JL, Kotz, KW, Hutchins, M, Chowhan, NM, Devabhaktuni, YD, Braly, P, Berenguer, RA, Shambaugh, SC, O'Rourke, TJ, Conkright, WA, Winkler, CF, Addo, FEK, Duic, JP, High, KP, Kutner, ME, Collins, R, Carrizosa, DR, Perry, DJ, Kailath, E, Rosen, N, Sotolongo, R, Shoham, S, Chen, T, Mullane, Kathleen M, Morrison, Vicki A, Camacho, Luis H, Arvin, Ann, McNeil, Shelly A, Durrand, Jessie, Campbell, Bernadette, Su, Shu-Chih, Chan, Ivan S F, Parrino, Janie, Kaplan, Susan S, Popmihajlov, Zoran, and Annunziato, Paula W

Published
2019
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7. Clinical characteristics and outcome of respiratory syncytial virus infection among adults hospitalized with influenza-like illness in France

Author

Seddik, K., Lesieur, Z., Bonmarin, I., Loulergue, P., Bodilis, H., Servera-Miyalou, M., Sadler, I., Momcilovic, S., Kanaan, R., Coolent, N., Tan Boun, K., Blanche, P., Charpentier, J., Daviaud, F., Mongardon, N., Bretagnol, A., Claessens, Y.E., Rozenberg, F., Yazdanpanah, Y., Burdet, C., Harent, S., Lachatre, M., Rioux, C., Bleibtreu, A., Casalino, E., Choquet, C., Leleu, A., Belghalem, K., Colosi, L., Ranaivoson, M., Verry, V., Pereira, L., Dupeyrat, E., Bernard, J., Emeyrat, N., Chavance, P., Debit, A., Aubier, M., Pradere, P., Justet, A., Mal, H., Brugiere, O., Papo, T., Goulenok, T., Boisseau, M., Jouenne, R., Alexandra, J.F., Raynaud-Simon, A., Lilamand, M., Cloppet-Fontaine, A., Becheur, K., Pelletier, A.L., Fidouh, N., Ralaimazava, P., Beaumale, F., Costa, Y., Munier, E., Betend, F., Amour, S., Loeffert, S., Francourt, K., Merle, C., Letois, F., Géraud, P., Driss, V., Noslier, S., Ray, M., Sebbane, M., Konaté, A., Bourdin, A., Klouche, K., Léglise, M.S., Couve-Deacon, E., Fruit, D., Fenerol, C., Vallejo, C., Jouneau, S., Lainé, F., Thébault, E., Fillatre, P., Le Pape, C., Beuzit, L., Chau, F., Carrat, F., Goderel, I., Loubet, P., Lenzi, N., Valette, M., Foulongne, V., Krivine, A., Houhou, N., Lagathu, G., Rogez, S., Alain, S., Duval, X., Galtier, F., Postil, D., Tattevin, P., Vanhems, P., Lina, B., and Launay, O.

Published
2017
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9. Collaborateurs de la précédente édition

Author

Allieu-Amara, S., primary, Aubry-Quénet, I., additional, Banu, I., additional, Baudot, M., additional, Bauduceau, B., additional, Blicklé, J.-F., additional, Bordier, L., additional, Bousquet, E., additional, Bringer, J., additional, Brunet, C., additional, Canaud, B., additional, Chambouleyron, M., additional, Chenine, L., additional, Chiheb, S., additional, Ciangura, C., additional, Colette, C., additional, Cosson, E., additional, Dupuy, O., additional, Fontbonne, A., additional, Galtier, F., additional, Giordan, A., additional, Golay, A., additional, Grimaldi, A., additional, Guillausseau, P.-J., additional, Ha Van, G., additional, Halbron, M., additional, Halimi, S., additional, Hartemann, A., additional, Jacqueminet, S., additional, Lagger, G., additional, Lasserre Moutet, A., additional, Lecornet-Sokol, E., additional, Leray-Moragues, H., additional, Marre, M., additional, Mayaudon, H., additional, Monnier, L., additional, Piperno, M., additional, Renard, É., additional, Renaud, S., additional, Richard, J.-L., additional, Robert, J.-J., additional, Roussel, R., additional, Sachon, C., additional, Schlienger, J.-L., additional, Schuldiner, S., additional, Travert, F., additional, Valensi, P., additional, Vergès, B., additional, Vialettes, B., additional, and Wojtusciszyn, A., additional

Published
2019
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10. Collaborateurs de la présente édition

Author

Aubry, I., primary, Banu, I., additional, Baudot, M., additional, Bauduceau, B., additional, Blicklé, J.-F., additional, Bonnet, F., additional, Bordier, L., additional, Bousquet, E., additional, Bringer, J., additional, Brunet, C., additional, Canaud, B., additional, Chambouleyron, M., additional, Chiheb, S., additional, Ciangura, C., additional, Colette, C., additional, Cosson, E., additional, Cristol, J.-P., additional, Dupuy, O., additional, El Azrak, A., additional, Fontbonne, A., additional, Galtier, F., additional, Giordan, A., additional, Golay, A., additional, Grimaldi, A., additional, Guillausseau, P.-J., additional, Ha Van, G., additional, Halimi, S., additional, Hartemann, A., additional, Jacqueminet, S., additional, Lagger, G., additional, Lasserre-Moutet, A., additional, Leray-Moragues, H., additional, Marre, M., additional, Monnier, L., additional, Morena, M., additional, Nabholz, N., additional, Piperno, M., additional, Renard, E., additional, Richard, J.-L., additional, Robert, J.-J., additional, Rochd, D., additional, Roussel, R., additional, Sachon, C., additional, Scheen, A., additional, Schlienger, J.-L., additional, Schuldiner, S., additional, Serny, C., additional, Travert, F., additional, Valensi, P., additional, Vergès, B., additional, Vialettes, B., additional, and Wojtusciszyn, A., additional

Published
2019
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17. Le diabète gestationnel: Référentiel élaboré par le Collège national des gynécologues et obstétriciens français (CNGOF) et par la Société francophone du diabète (SFD) – 2010

Author

Vambergu, Anne, Lepercq, J., Vayssiere, C., Boulot, P., Burdet, I., Criballet, G., Fau, C., Grandjean, H., Simeoni, U., Vambergue, A., Beucher, G., Burguet, A., Cosson, E., Deruelle, P., Galtier, F., Guedj, A.-M., Guyard-Boileau, B., Hieronimus, S., Jacqueminet, S., Jannot-Lamotte, M.-F., Kerlan, V., Laloi-Michelin, M., Le meaux, J.-P., Mitanchez, D., Thiebaugeorges, O., Verier-Mine, O., and Virally, M.

Published
2010
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27. Liste des collaborateurs

Author

Allieu-Amara, S., primary, Aubry-Quénet, I., additional, Banu, I., additional, Baudot, M., additional, Bauduceau, B., additional, Blicklé, J.-F., additional, Bordier, L., additional, Bousquet, E., additional, Bringer, J., additional, Brunet, C., additional, Canaud, B., additional, Chambouleyron, M., additional, Chenine, L., additional, Chiheb, S., additional, Ciangura, C., additional, Colette, C., additional, Cosson, E., additional, Dupuy, O., additional, Fontbonne, A., additional, Galtier, F., additional, Giordan, A., additional, Golay, A., additional, Grimaldi, A., additional, Guillausseau, P.-J., additional, Ha Van, G., additional, Halbron, M., additional, Halimi, S., additional, Hartemann, A., additional, Jacqueminet, S., additional, Lagger, G., additional, Lasserre Moutet, A., additional, Lecornet-Sokol, E., additional, Leray-Moraguès, H., additional, Marre, M., additional, Mayaudon, H., additional, Monnier, L., additional, Piperno, M., additional, Renard, É., additional, Renaud, S., additional, Richard, J.-L., additional, Robert, J.-J., additional, Roussel, R., additional, Sachon, C., additional, Schlienger, J.-L., additional, Schuldiner, S., additional, Travert, F., additional, Valensi, P., additional, Vergès, B., additional, Vialettes, B., additional, and Wojtusciszyn, A., additional

Published
2014
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29. Liste des collaborateurs

Author

Allieu-Amara, S., primary, Aubry-Quénet, I., additional, Banu, I., additional, Baudot, M., additional, Bauduceau, B., additional, Blicklé, J.-F., additional, Bordier, L., additional, Bousquet, E., additional, Bringer, J., additional, Brunet, C., additional, Canaud, B., additional, Chambouleyron, M., additional, Chenine, L., additional, Chiheb, S., additional, Ciangura, C., additional, Colette, C., additional, Cosson, E., additional, Dupuy, O., additional, Fontbonne, A., additional, Galtier, F., additional, Giordan, A., additional, Golay, A., additional, Grimaldi, A., additional, Guillausseau, P.-J., additional, Ha Van, G., additional, Halbron, M., additional, Halimi, S., additional, Hartemann, A., additional, Jacqueminet, S., additional, Lagger, G., additional, Lasserre Moutet, A., additional, Lecornet-Sokol, E., additional, Leray-Moraguès, H., additional, Marre, M., additional, Mayaudon, H., additional, Monnier, L., additional, Renard, É., additional, Renaud, S., additional, Richard, J.-L., additional, Robert, J.-J., additional, Roussel, R., additional, Sachon, C., additional, Schlienger, J.-L., additional, Schuldiner, S., additional, Travert, F., additional, Valensi, P., additional, Vergès, B., additional, and Vialettes, B., additional

Published
2010
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37. Interim 2017/18 influenza seasonal vaccine effectiveness: combined results from five European studies

Author

Rondy, M, Kissling, E, Emborg, Hd, Gherasim, A, Pebody, R, Trebbien, R, Pozo, F, Larrauri, A, Mcmenamin, J, Valenciano, M, Kaic, B, Kurecic Filipovic, S, Visekruna-Vucina, V, Pem Novosel, I, Lovric, Z, Petrović, G, Krause, Tg, Fischer, Tk, Lina, B, Falchi, Antonella, Vilcu, Am, Souty, C, Blanchon, T, van der Werf, S, Enouf, V, Behillil, S, Valette, M, Bernard-Stoecklin, S, Lévy-Bruhl, D, Launay, O, Loulergue, P, Lenzi, N, Lesieur, Z, L'Honneur, As, Galtier, F, Agostini, C, Serrand, C, Merle, C, Foulongne, V, Vanhems, P, Lainé, F, Lagathu, G, Carrat, F, Buda, S, Preuss, U, Prahm, K, Schweiger, B, Wedde, M, Heider, A, Martin, M, Biere, B, Duerrwald, R, Domegan, L, Coughlan, L, O’Donnell, J, Joyce, M, Collins, C, Dunford, L, Martin Moran, Josè Manuel, Tuite, G, Duffy, M, Connell, J, de Gascun, C, Rizzo, C, Bella, A, Alfonsi, V, Castrucci, Mr, Puzelli, S, Pagani, E, Ghisetti, V, Pariani, E, Baldanti, F, Palù, G, D'Agaro, P, Ansaldi, F, Affanni, P, Rossolini, Gm, Camilloni, B, Bagnarelli, P, Sanguinetti, M, Atripaldi, L, Chironna, M, Serra, C, Vitale, F, Germinario, C, Orsi, A, Manini, I, Montomoli, E, Napoli, C, Orsi, Gb, Casado, I, Castilla, J, Fernandino, L, Martínez-Baz, I, Ezpeleta, G, Navascués, A, Pérez-García, A, Aguinaga, A, Ezpeleta, C, Meijer, A, van den Brink, S, van der Hoek, W, Goderski, G, Wijsman, L, Bagheri, M, Dijkstra, F, de Lange, M, Marzec, T, Overduin, P, Teirlinck, A, Wentink, E, Donker, G, Marbus, S, van Gageldonk- Lafeber, R, Schneeberger, P, van Oosterheert JJ, Schweitzer, V, Groeneveld, G, Nunes, B, RIBEIRO MACHADO, CARLOS AUGUSTO, Rodrigues, Ap, DIAZ GOMEZ, MARIA VANESSA, Kislaya, I, Guiomar, R, Pechirra, P, Cristóvão, P, Costa, I, Panarra, A, Côrte-Real, R, Poças, J, João Peres, M, García Comas, L, Marisquerena, Mei, Galán, Jc, Folgueira, D, Gonzalez Carril, F, Sancho Martínez, R, Cilla, G, García Cenoz, M, Quiñones Rubio, C, Martinez Ochoa, E, Blasco, M, Gimenez Duran, J, Vanrell, Jm, Reina, J, Castrillejo, D, Gherasim, Am, Delgado, C, Oliva, J, Casas, I, García, M, Latorre, M, Milagro Beamonte AM, Martinez Sapiñ, A, Oribe Amores, M, Aizpurúa, A, Montes, Marco, Zakikhany, K, Brytting, M, Wiman, Å, Carnahan, A, Warburton, F, Djennad, A, Ellis, J, Andrews, N, Marques, D, Cottrell, S, Reynolds, Alexander, Gunson, R, Galiano, M, Lackenby, A, Robertson, C, O’Doherty, M, Sinnathamby, M, Yonova, I, Moore, C, Sartaj, M, de Lusignan, S, Zambon, M, Moren, A, Penttinen, P., Unión Europea, EpiConcept [Paris], Statens Serum Institut [Copenhagen], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Pathogénèse et contrôle des infections chroniques (PCCI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre Hospitalier Universitaire de Montpellier (CHU Montpellier ), Rondy M., Kissling E., Emborg H.-D., Gherasim A., Pebody R., Trebbien R., Pozo F., Larrauri A., McMenamin J., Valenciano M., Kaic B., Filipovic S.K., Visekruna-Vucina V., Novosel I.P., Lovric Z., Petrovic G., Krause T.G., Fische T.K., Lina B., Falchi A., Vilcu A.-M., Souty C., Blanchon T., van der Werf S., Enouf V., Behillil S., Valette M., Bernard-Stoecklin S., Levy-Bruhl D., Launay O., Loulergue P., Lenzi N., Lesieur Z., L'Honneur A.-S., Galtier F., Agostini C., Serrand C., Merle C., Foulongne V., Vanhems P., Laine F., Lagathu G., Carrat F., Buda S., Preuss U., Prahm K., Schweiger B., Wedde M., Heider A., Martin M., Biere B., Duerrwald R., Domegan L., Coughlan L., O'Donnell J., Joyce M., Collins C., Dunford L., Moran J., Tuite G., Duffy M., Connell J., de Gascun C., Rizzo C., Bella A., Alfonsi V., Castrucci M.R., Puzelli S., Pagani E., Ghisetti V., Pariani E., Baldanti F., Palu G., D'Agaro P., Ansaldi F., Affanni P., Rossolini G.M., Camilloni B., Bagnarelli P., Sanguinetti M., Atripaldi L., Chironna M., Serra C., Vitale F., Germinario C., Orsi A., Manini I., Montomoli E., Napoli C., Orsi G.B., Casado I., Castilla J., Fernandino L., Martinez-Baz I., Ezpeleta G., Navascues A., Perez-Garcia A., Aguinaga A., Ezpeleta C., Meijer A., van den Brink S., van der Hoek W., Goderski G., Wijsman L., Bagheri M., Dijkstra F., de Lange M., Marzec T., Overduin P., Teirlinck A., Wentink E., Donker G., Marbus S., van Gageldonk-Lafeber R., Schneeberger P., van Oosterheert J.J., Schweitzer V., Groeneveld G., Nunes B., Machado A., Rodrigues A.P., Gomez V., Kislaya I., Guiomar R., Pechirra P., Cristovao P., Costa I., Panarra A., Corte-Real R., Pocas J., Peres M.J., Comas L.G., Marisquerena M.E.I., Galan J.C., Folgueira M.D., Carril F.G., Martinez R.S., Cilla G., Cenoz M.G., Rubio C.Q., Ochoa E.M., Blasco M., Duran J.G., Vanrell J.M., Reina J., Castrillejo D., Gherasim A.M., Delgado C., Oliva J., Casas I., Garcia M., Latorre M., Beamonte A.M.M., Sapina A.M., Amores M.O., Aizpurua A., Montes M., Zakikhany K., Brytting M., Wiman A., Carnahan A., Warburton F., Djennad A., Ellis J., Andrews N., Marques D., Cottrell S., Reynolds A., Gunson R., Galiano M., Lackenby A., Robertson C., O'Doherty M., Sinnathamby M., Yonova I., Moore C., Sartaj M., de Lusignan S., Zambon M., Moren A., Penttinen P., Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses (GMV-ARN (UMR_3569 / U-Pasteur_2)), Institut Pasteur [Paris] (IP)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Marc, Rondy, Esther, Kissling, Hanne-Dorthe, Emborg, Alin, Gherasim, Richard, Pebody, Ramona, Trebbien, Francisco, Pozo, Amparo, Larrauri, Jim, Mcmenamin, Marta, Valenciano, D'Agaro, Pierlanfranco, De Lusignan, S, and Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Montpellier (CHU Montpellier )-Université de Montpellier (UM)

Subjects
0301 basic medicine, Male, Pediatrics, Epidemiology, viruses, Influenza B viru, influenza, influenza vaccine effectiveness, influenza vaccination, case control study, multicentre study, Europe, Europe, case control study, influenza, influenza vaccination, influenza vaccine effectiveness, multicentre study, 0302 clinical medicine, Influenza A Virus, H1N1 Subtype, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Interim, Pandemic, Influenza A Virus, 030212 general & internal medicine, QA, Influenza vaccine effectiveness, Child, media_common, Vaccine Effectiveness, Vaccination, virus diseases, Middle Aged, 3. Good health, Treatment Outcome, Influenza Vaccines, Child, Preschool, H3N2 Subtype, Female, Seasons, Influenza Vaccine, Rapid Communication, Human, Adult, RM, medicine.medical_specialty, Adolescent, Influenza vaccine, 030106 microbiology, Case control study, Multicentre study, European studies, Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA, 03 medical and health sciences, Virology, Influenza, Human, medicine, media_common.cataloged_instance, Humans, H1N1 Subtype, Vacina Antigripal, European Union, European union, Preschool, Pandemics, Aged, Influenza A Virus, H3N2 Subtype, Cuidados de Saúde, Public Health, Environmental and Occupational Health, Infant, Newborn, Infant, Influenza a, influenza vaccine effectivene, Newborn, Influenza, respiratory tract diseases, Influenza vaccination, Influenza B virus, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Determinantes da Saúde e da Doença, [SDV.IMM.VAC]Life Sciences [q-bio]/Immunology/Vaccinology
Abstract

Between September 2017 and February 2018, influenza A(H1N1)pdm09, A(H3N2) and B viruses (mainly B/Yamagata, not included in 2017/18 trivalent vaccines) co-circulated in Europe. Interim results from five European studies indicate that, in all age groups, 2017/18 influenza vaccine effectiveness was 25 to 52% against any influenza, 55 to 68% against influenza A(H1N1)pdm09, -42 to 7% against influenza A(H3N2) and 36 to 54% against influenza B. 2017/18 influenza vaccine should be promoted where influenza still circulates. Funding: The five studies have received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 634446 to conduct the study in individuals aged 65 years or more. ECDC has contributed to fund some study sites of the EU-PC study under the Framework contract No ECDC/2014/026 for the individuals aged less than 65 years. All study teams are very grateful to all patients, general practitioners, paediatricians, hospital teams, laboratory teams, regional epidemiologists who have contributed to the studies. We acknowledge the authors, originating and submitting laboratories of the sequences from GISAID’s EpiFlu Database used for this study. All submitters of data may be contacted directly via the GISAID website www.gisaid.org Sí

Published
2018
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40. Safety and efficacy of inactivated varicella zoster virus vaccine in immunocompromised patients with malignancies: a two-arm, randomised, double-blind, phase 3 trial

Author

Mullane, Kathleen M, primary, Morrison, Vicki A, additional, Camacho, Luis H, additional, Arvin, Ann, additional, McNeil, Shelly A, additional, Durrand, Jessie, additional, Campbell, Bernadette, additional, Su, Shu-Chih, additional, Chan, Ivan S F, additional, Parrino, Janie, additional, Kaplan, Susan S, additional, Popmihajlov, Zoran, additional, Annunziato, Paula W, additional, Cerana, S, additional, Dictar, MO, additional, Bonvehi, P, additional, Tregnaghi, JP, additional, Fein, L, additional, Ashley, D, additional, Singh, M, additional, Hayes, T, additional, Playford, G, additional, Morrissey, O, additional, Thaler, J, additional, Kuehr, T, additional, Greil, R, additional, Pecherstorfer, M, additional, Duck, L, additional, Van Eygen, K, additional, Aoun, M, additional, De Prijck, B, additional, Franke, FA, additional, Barrios, CHE, additional, Mendes, AVA, additional, Serrano, SV, additional, Garcia, RF, additional, Moore, F, additional, Camargo, JFC, additional, Pires, LA, additional, Alves, RS, additional, Radinov, A, additional, Oreshkov, K, additional, Minchev, V, additional, Hubenova, AI, additional, Koynova, T, additional, Ivanov, I, additional, Rabotilova, B, additional, Petrov, PA, additional, Chilingirov, P, additional, Karanikolov, S, additional, Raynov, J, additional, Grimard, D, additional, McNeil, S, additional, Kumar, D, additional, Larratt, LM, additional, Weiss, K, additional, Delage, R, additional, Diaz-Mitoma, FJ, additional, Cano, PO, additional, Couture, F, additional, Carvajal, P, additional, Yepes, A, additional, Torres Ulloa, R, additional, Fardella, P, additional, Caglevic, C, additional, Rojas, C, additional, Orellana, E, additional, Gonzalez, P, additional, Acevedo, A, additional, Galvez, KM, additional, Gonzalez, ME, additional, Franco, S, additional, Restrepo, JG, additional, Rojas, CA, additional, Bonilla, C, additional, Florez, LE, additional, Ospina, AV, additional, Manneh, R, additional, Zorica, R, additional, Vrdoljak, DV, additional, Samarzija, M, additional, Petruzelka, L, additional, Vydra, J, additional, Mayer, J, additional, Cibula, D, additional, Prausova, J, additional, Paulson, G, additional, Ontaneda, M, additional, Palk, K, additional, Vahlberg, A, additional, Rooneem, R, additional, Galtier, F, additional, Postil, D, additional, Lucht, F, additional, Laine, F, additional, Launay, O, additional, Laurichesse, H, additional, Duval, X, additional, Cornely, OA, additional, Camerer, B, additional, Panse, J, additional, Zaiss, M, additional, Derigs, H-G, additional, Menzel, H, additional, Verbeek, M, additional, Georgoulias, V, additional, Mavroudis, D, additional, Anagnostopoulos, A, additional, Terpos, E, additional, Cortes, D, additional, Umanzor, J, additional, Bejarano, S, additional, Galeano, RW, additional, Wong, RSM, additional, Hui, P, additional, Pedrazzoli, P, additional, Ruggeri, L, additional, Aversa, F, additional, Bosi, A, additional, Gentile, G, additional, Rambaldi, A, additional, Contu, A, additional, Marei, L, additional, Abbadi, A, additional, Hayajneh, W, additional, Kattan, J, additional, Farhat, F, additional, Chahine, G, additional, Rutkauskiene, J, additional, Marfil Rivera, LJ, additional, Lopez Chuken, YA, additional, Franco Villarreal, H, additional, Lopez Hernandez, J, additional, Blacklock, H, additional, Lopez, RI, additional, Alvarez, R, additional, Gomez, AM, additional, Quintana, TS, additional, Moreno Larrea, MDC, additional, Zorrilla, SJ, additional, Alarcon, E, additional, Samanez, FCA, additional, Caguioa, PB, additional, Tiangco, BJ, additional, Mora, EM, additional, Betancourt-Garcia, RD, additional, Hallman-Navarro, D, additional, Feliciano-Lopez, LJ, additional, Velez-Cortes, HA, additional, Cabanillas, F, additional, Ganea, DE, additional, Ciuleanu, TE, additional, Ghizdavescu, DG, additional, Miron, L, additional, Cebotaru, CL, additional, Cainap, CI, additional, Anghel, R, additional, Dvorkin, MV, additional, Gladkov, OA, additional, Fadeeva, NV, additional, Kuzmin, AA, additional, Lipatov, ON, additional, Zbarskaya, II, additional, Akhmetzyanov, FS, additional, Litvinov, IV, additional, Afanasyev, BV, additional, Cherenkova, M, additional, Lioznov, D, additional, Lisukov, IA, additional, Smirnova, YA, additional, Kolomietz, S, additional, Halawani, H, additional, Goh, YT, additional, Drgona, L, additional, Chudej, J, additional, Matejkova, M, additional, Reckova, M, additional, Rapoport, BL, additional, Szpak, WM, additional, Malan, DR, additional, Jonas, N, additional, Jung, CW, additional, Lee, DG, additional, Yoon, SS, additional, Lopez Jimenez, J, additional, Duran Martinez, I, additional, Rodriguez Moreno, JF, additional, Solano Vercet, C, additional, de la Camara, R, additional, Batlle Massana, M, additional, Yeh, S-P, additional, Chen, C-Y, additional, Chou, H-H, additional, Tsai, C-M, additional, Chiu, C-H, additional, Siritanaratkul, N, additional, Norasetthada, L, additional, Sriuranpong, V, additional, Seetalarom, K, additional, Akan, H, additional, Dane, F, additional, Ozcan, MA, additional, Ozsan, GH, additional, Kalayoglu Besisik, SF, additional, Cagatay, A, additional, Yalcin, S, additional, Peniket, A, additional, Mullan, SR, additional, Dakhil, KM, additional, Sivarajan, K, additional, Suh, JJ-G, additional, Sehgal, A, additional, Marquez, F, additional, Gomez, EG, additional, Mullane, MR, additional, Skinner, WL, additional, Behrens, RJ, additional, Trevarthe, DR, additional, Mazurczak, MA, additional, Lambiase, EA, additional, Vidal, CA, additional, Anac, SY, additional, Rodrigues, GA, additional, Baltz, B, additional, Boccia, R, additional, Wertheim, MS, additional, Holladay, CS, additional, Zenk, D, additional, Fusselman, W, additional, Wade III, JL, additional, Jaslowsk, AJ, additional, Keegan, J, additional, Robinson, MO, additional, Go, RS, additional, Farnen, J, additional, Amin, B, additional, Jurgens, D, additional, Risi, GF, additional, Beatty, PG, additional, Naqvi, T, additional, Parshad, S, additional, Hansen, VL, additional, Ahmed, M, additional, Steen, PD, additional, Badarinath, S, additional, Dekker, A, additional, Scouros, MA, additional, Young, DE, additional, Graydon Harker, W, additional, Kendall, SD, additional, Citron, ML, additional, Chedid, S, additional, Posada, JG, additional, Gupta, MK, additional, Rafiyath, S, additional, Buechler-Price, J, additional, Sreenivasappa, S, additional, Chay, CH, additional, Burke, JM, additional, Young, SE, additional, Mahmood, A, additional, Kugler, JW, additional, Gerstner, G, additional, Fuloria, J, additional, Belman, ND, additional, Geller, R, additional, Nieva, J, additional, Whittenberger, BP, additional, Wong, BMY, additional, Cescon, TP, additional, Abesada-Terk, G, additional, Guarino, MJ, additional, Zweibach, A, additional, Ibrahim, EN, additional, Takahashi, G, additional, Garrison, MA, additional, Mowat, RB, additional, Choi, BS, additional, Oliff, IA, additional, Singh, J, additional, Guter, KA, additional, Ayrons, K, additional, Rowland, KM, additional, Noga, SJ, additional, Rao, SB, additional, Columbie, A, additional, Nualart, MT, additional, Cecchi, GR, additional, Campos, LT, additional, Mohebtash, M, additional, Flores, MR, additional, Rothstein-Rubin, R, additional, O'Connor, BM, additional, Soori, G, additional, Knapp, M, additional, Miranda, FG, additional, Goodgame, BW, additional, Kassem, M, additional, Belani, R, additional, Sharma, S, additional, Ortiz, T, additional, Sonneborn, HL, additional, Markowitz, AB, additional, Wilbur, D, additional, Meiri, E, additional, Koo, VS, additional, Jhangiani, HS, additional, Wong, L, additional, Sanani, S, additional, Lawrence, SJ, additional, Jones, CM, additional, Murray, C, additional, Papageorgiou, C, additional, Gurtler, JS, additional, Ascensao, JL, additional, Venigalla, ML, additional, D'Andrea, M, additional, De Las Casas, C, additional, Haile, DJ, additional, Qazi, FU, additional, Santander, JL, additional, Thomas, MR, additional, Rao, VP, additional, Craig, M, additional, Garg, RJ, additional, Robles, R, additional, Lyons, RM, additional, Stegemoller, RK, additional, Goel, S, additional, Garg, S, additional, Lowry, P, additional, Lynch, C, additional, Lash, B, additional, Repka, T, additional, Baker, J, additional, Goueli, BS, additional, Campbell, TC, additional, Van Echo, DA, additional, Lee, YJ, additional, Reyes, EA, additional, Senecal, FM, additional, Donnelly, G, additional, Byeff, P, additional, Weiss, R, additional, Reid, T, additional, Roeland, E, additional, Goel, A, additional, Prow, DM, additional, Brandt, DS, additional, Kaplan, HG, additional, Payne, JE, additional, Boeckh, MG, additional, Rosen, PJ, additional, Mena, RR, additional, Khan, R, additional, Betts, RF, additional, Sharp, SA, additional, Morrison, VA, additional, Fitz-Patrick, D, additional, Congdon, J, additional, Erickson, N, additional, Abbasi, R, additional, Henderson, S, additional, Mehdi, A, additional, Wos, EJ, additional, Rehmus, E, additional, Beltzer, L, additional, Tamayo, RA, additional, Mahmood, T, additional, Reboli, AC, additional, Moore, A, additional, Brown, JM, additional, Cruz, J, additional, Quick, DP, additional, Potz, JL, additional, Kotz, KW, additional, Hutchins, M, additional, Chowhan, NM, additional, Devabhaktuni, YD, additional, Braly, P, additional, Berenguer, RA, additional, Shambaugh, SC, additional, O'Rourke, TJ, additional, Conkright, WA, additional, Winkler, CF, additional, Addo, FEK, additional, Duic, JP, additional, High, KP, additional, Kutner, ME, additional, Collins, R, additional, Carrizosa, DR, additional, Perry, DJ, additional, Kailath, E, additional, Rosen, N, additional, Sotolongo, R, additional, Shoham, S, additional, and Chen, T, additional

Published
2019
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42. Moderate influenza vaccine effectiveness against hospitalisation with A(H3N2) and A(H1N1) influenza in 2013–14: Results from the InNHOVE network

Author

Rondy, M., Castilla, J., Launay, O., Costanzo, S., Ezpeleta, C., Galtier, F., de Gaetano Donati, K., Moren, A., Beristain, X., Chamorro, J., Gabari, M., Artajo, P., Lameiro, F., Barrado, L., Ortega, M., Torres, M., Garcia Irure, J. J., Irisarri, F., Garcia Cenoz, M., Guevara, M., Casado, I., Diaz, J., Martinez-Baz, I., Lenzi, N., Lesieur, Z., Bonmarin, I., Merle, C., Foulongne, V., Letois, F., Driss, V., Geraud, P., Bourdin, A., Landreau, L., Konate, A., Corne, P., Sebbane, M., Klouche, K., Leglise, M. -S., Loulergue, P., Kanaan, R., Dumas, F., Krivine, A., Moncilovic, S., Ali, N., Duval, X., Costa, Y., Ait Naman, R., Yazdapanah, Y., Caseris, M., Dournon, N., Papo, T., Dossier, A., Becheur, H., Pelletier, A. -L., Mal, M., Marceau, A., Aubier, M., Bories, R., Casalino, E., Choquet, C., Houhou, N., Vanhems, P., Regis, C., Jouneau, S., Laine, F., Tattevin, P., Beuzit, L., Thebault, E., Fey, S., Lagathu et Sophie Cha, G., Postil, D., Alcolea, S., Rogez, S., Valette, M., Lina, B., Cauda, R., Taccari, F., Santangelo, R., Perlasca, F., Fichera, G., Dara, M., Iacoviello, L., Olivieri, M., CIC - Biotherapie - AP-HP (cochin - Pasteur), Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Saint-Eloi, CIC Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-CHU Saint-Eloi-Institut National de la Santé et de la Recherche Médicale (INSERM), Biocommunication en Cardio-Métabolique (BC2M), Université de Montpellier (UM), Hôpital Saint Eloi (CHRU Montpellier), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Saint Eloi (CHRU Montpellier), and Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Male, [SDV]Life Sciences [q-bio], Logistic regression, medicine.disease_cause, Influenza A Virus, H1N1 Subtype, 0302 clinical medicine, Outcome Assessment, Health Care, Influenza A virus, Immunology and Allergy, Medicine, 030212 general & internal medicine, hospital, Young adult, media_common, Aged, 80 and over, Influenza vaccine, Vaccination, virus diseases, Middle Aged, Research Papers, 3. Good health, Hospitalization, case control studies, Italy, Influenza Vaccines, Female, France, Seasons, Adult, medicine.medical_specialty, Adolescent, 030231 tropical medicine, Immunology, Young Adult, 03 medical and health sciences, Internal medicine, Influenza, Human, A h1n1 influenza, Humans, media_common.cataloged_instance, European Union, European union, Intensive care medicine, Aged, Pharmacology, business.industry, Influenza A Virus, H3N2 Subtype, Case-control study, Influenza, multicentre studies, Logistic Models, Spain, Case-Control Studies, business, Sentinel Surveillance
Abstract

International audience; We conducted a multicentre test negative case control study to estimate the 2013–14 influenza vaccine effectiveness (IVE) against hospitalised laboratory confirmed influenza in 12 hospitals in France, Italy and Spain. We included all ≥18 years hospitalised patients targeted by local influenza vaccination campaign reporting an influenza-like illness within 7 days before admission. We defined as cases patients RT-PCR positive for influenza and as controls those negative for all influenza virus. We used a logistic regression to calculate IVE adjusted for country, month of onset, chronic diseases and age. We included 104 A(H1N1)pdm09, 157 A(H3N2) cases and 585 controls. The adjusted IVE was 42.8% (95%CI: 6.3;65;0) against A(H1N1)pdm09. It was respectively 61.4% (95%CI: −1.9;85.4), 39.4% (95%CI: −32.2;72.2) and 19.7% (95%CI:-148.1;74.0) among patients aged 18–64, 65–79 and ≥80 years. The adjusted IVE against A(H3N2) was 38.1% (95%CI: 8.3;58.2) overall. It was respectively 7.8% (95%CI: −145.3;65.4), 25.6% (95%CI: −36.0;59.2) and 55.2% (95%CI: 15.4;76.3) among patients aged 18–64, 65–79 and ≥80 years. These results suggest a moderate and age varying effectiveness of the 2013–14 influenza vaccine to prevent hospitalised laboratory-confirmed influenza. While vaccination remains the most effective prevention measure, developing more immunogenic influenza vaccines is needed to prevent severe outcomes among target groups. © 2016 Taylor & Francis.

Published
2016
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45. Low 2016/17 season vaccine effectiveness against hospitalised influenza A(H3N2) among elderly: awareness warranted for 2017/18 season

Author

Rondy, M., Gherasim, A., Casado, I., Launay, O., Rizzo, C., Pitigoi, D., Mickiene, A., Marbus, S. D., Machado, A., Syrjanen, R. K., Pem-Novose, I., Horvath, J. K., Larrauri, A., Castilla, J., Vanhems, P., Alfonsi, V., Ivanciuc, A. E., Kuliese, M., Van Gageldonk-Lafeber, R., Gomez, V., Ikonen, N., Lovric, Z., Ferenczi, A., Moren, A., Pozo, F., Garcia, M., Latorre, M., Omenaca, M., Oribe Amores, M., Munoz, N., Cilla, G., Fernandino, L., Martinez-Baz, I., Navascues, A., Perez-Garcia, A., Aguinaga, A., Ezpeleta, C., Bella, A., Appelgren, E. C., Castrucci, M. R., Puzelli, S., Chironna, M., Germinario, C., Ansaldi, F., Manini, I., Montomoli, E., Lupulescu, E., Lazar, M., Mihai, M. E., Cherciu, C. M., Dinu, S., Tecu, C., Nitescu, M., Bacruban, R., Azamfire, D., Dumitrescu, A., Ianosik, E., Ceausu, E., Popescu, C. P., Florescu, S. A., Tardei, G., Bejan, C., Teodor, A., Juganariu, G., Plesca, C., Duca, E., Lenzi, N., Lesieur, Z., Loulergue, P., Galtier, F., Agostini, C., Ray, M., Merle, C., Foulongne, V., Lina, B., Laine, F., De Guibert, S., Lagathu, G., Tattevin, P., Jouneau, S., Esvant, A., Le Gallou, T., Carrat, F., Mawuvi, G., Chau, F., Nohynek, H., Haveri, A., Gefenaite, G., Velyvyte, D., Jancoriene, L., Zablockiene, B., Ambrozaitis, A., Grimalauskaite, R., Damuleviciene, G., Lesauskaite, V., Bagdonas, A., Nunes, B., Kislaya, I., Rodrigues, A. P., Gomes, V., Corte-Real, R., Pocas, J., Peres, M. J., Bernard, K., Kurecic-Filipovic, S., Visekruna Vucina, V., Topic, A., Papic, N., Budimir, J., Oroszi, B., Meijer, A., Van Der Hoek, W., Schneeberger, P. M., EpiConcept [Paris], Institute of Health 'Carlos III', CIBER de Epidemiología y Salud Pública (CIBERESP), IDISNA, Pamplona, CIC Cochin Pasteur (CIC 1417), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôtel-Dieu-Université Paris Descartes - Paris 5 (UPD5)-Groupe hospitalier Broca-Institut National de la Santé et de la Recherche Médicale (INSERM), F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC), Istituto Superiore di Sanità (ISS), University of Medicine and Pharmacy 'Carol Davila' Bucharest (UMPCD), Lithuanian University of health Sciences, National Institute for Public Health and the Environment [Bilthoven] (RIVM), Instituto Nacional de Saùde Dr Ricardo Jorge [Portugal] (INSA), National Institute for Health and Welfare [Helsinki], Croatian Institute of Public Health [Zagreb] (CIPH), Office of the Chief Medical Officer, Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), Laboratoire des pathogènes émergents -- Emerging Pathogens Laboratory (LPE-Fondation Mérieux), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institute of Biology Bucharest of Romanian Academy, Epidemiology Department, Institut National de la Santé et de la Recherche Médicale (INSERM)-Groupe hospitalier Broca-Université Paris Descartes - Paris 5 (UPD5)-Hôtel-Dieu-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Istituto Superiore di Sanità Rome, Rome, Italy, Centre International de Recherche en Infectiologie - UMR (CIRI), Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), EpiConcept, Unión Europea, CIC Cochin Pasteur ( CIC 1417 ), Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Cochin [AP-HP]-Hôtel-Dieu-Groupe hospitalier Broca-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Paris Descartes - Paris 5 ( UPD5 ), F-CRIN, I-REIVAC, Institut National de la Santé et de la Recherche Médicale ( INSERM ), National Center for Epidemiology Surveillance and Health Promotion, Istituto Superiore di Sanita [Rome], 'Carol Davila' University of Medicine and Pharmacy, National Institute for Public Health and the Environment [Bilthoven] ( RIVM ), Instituto Nacional de Saúde Doutor Ricardo Jorge, Croatian Institute of Public Health, Zagreb, Hospices Civils de Lyon ( HCL ), Centre International de Recherche en Infectiologie ( CIRI ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-École normale supérieure - Lyon ( ENS Lyon ), Istituto Superiore de Sanita, HAL-UPMC, Gestionnaire, École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Male, 0301 basic medicine, Pediatrics, Epidemiology, Efetividade da Vacina Antigripal, A(H3N2), Influenza, cases control, elderly, hospitalisation, vaccine effectiveness, Elderly, 0302 clinical medicine, vaccine, Outcome Assessment, Health Care, Influenza A Virus, Hospitalisation, awareness, 030212 general & internal medicine, media_common, Vaccine effectiveness, virus diseases, [ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie, Middle Aged, Hospitals, 3. Good health, Hospitalization, Influenza Vaccines, H3N2 Subtype, Female, Seasons, influenza, Rapid Communication, Human, Adult, medicine.medical_specialty, Adolescent, Influenza vaccine, 030106 microbiology, Outcome Assessment (Health Care), 03 medical and health sciences, [SDV.IMM.VAC] Life Sciences [q-bio]/Immunology/Vaccinology, Virology, Influenza, Human, medicine, Aged, European Union, Humans, Influenza A Virus, H3N2 Subtype, media_common.cataloged_instance, Vacina Antigripal, European union, Cases control, Cases Control, business.industry, Public health, Cuidados de Saúde, Public Health, Environmental and Occupational Health, Case-control study, Influenza a, Confidence interval, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Emergency medicine, [ SDV.IMM.VAC ] Life Sciences [q-bio]/Immunology/Vaccinology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.IMM.VAC]Life Sciences [q-bio]/Immunology/Vaccinology, Prevention control, business
Abstract

Members of the I-Move+hospital working group - Portugal: B. Nunes, I. Kislaya, A.P. Rodrigues (National Health Institute Doutor Ricardo Jorge, Lisbon), V. Gomes, R. Côrte-Real (Centro Hospitalar de Lisboa Central, Lisbon), J. Poças, M.J. Peres (Centro Hospitalar de Setúbal, Setúbal). In a multicentre European hospital study we measured influenza vaccine effectiveness (IVE) against A(H3N2) in 2016/17. Adjusted IVE was 17% (95% confidence interval (CI): 1 to 31) overall; 25% (95% CI: 2 to 43) among 65-79-year-olds and 13% (95% CI: -15 to 30) among those ≥ 80 years. As the A(H3N2) vaccine component has not changed for 2017/18, physicians and public health experts should be aware that IVE could be low where A(H3N2) viruses predominate. Funding: The I-MOVE+ project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 634446. The Lithuanian I-MOVE+ study sites were supported by a grant from the Research Council of Lithuania (SEN-03/2015). info:eu-repo/semantics/publishedVersion

Published
2017
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46. Repeated seasonal influenza vaccination among elderly in Europe: Effects on laboratory confirmed hospitalised influenza

Author

Rondy, M., Launay, O., Castilla, J., Costanzo, S., Puig-Barbera, J., Gefenaite, G., Larrauri, A., Rizzo, C., Pitigoi, D., Syrjanen, R. K., Machado, A., Filipovic, S. K., Horvath, J. K., Paradowska-Stankiewicz, I., Marbus, S., Moren, A., Valenciano, M., Lenzi, N., Lesieur, Z., Loulergue, P., Galtier, F., Ray, M., Foulongne, V., Letois, F., Merle, C., Vanhems, P., Lina, B., Casado, I., Diaz-Gonzalez, J., Guevara, M., Martinez-Baz, I., Fernandino, L., Navascues, A., Ezpeleta, C., Chamorro, J., Barrado, L., Ortega, M. T., De Gaetano Donati, K., Cauda, R., Donato, C., Taccari, F., Campana, L., Santangelo, R., Perlasca, F., Fichera, G., Dara, M., Iacoviello, L., Olivieri, M., Alfonsi, V., Bella, A., Puzelli, S., Castrucci, M. R., Orsi, A., Ansaldi, F., Manini, I., Montomoli, E., Chironna, M., Germinario, C., Diez-Domingo, J., Sanudo, B., Carratala Munuera, C., Correcher Medina, P., Gil Guillen, V., Larrea Gonzalez, R., Limon Ramirez, R., Mico Esparza, J. L., Mollar Maseres, J., Otero Reigada, M. C., Tortajada Girbes, M., Schwarz Chavarri, G., Ambrozaitis, A., Jancoriene, L., Zablockiene, B., Zagminas, K., Aukse, M., Damuleviciene, G., Grimalauskaite, R., Kuliese, M., Lesauskaite, V., Velyvyte, D., Niesters, H., Stolk, R. P., Zagmines, K., Rahamat-Langendoen, J., Gherasim, A., Pozo, F., Altzibar, J., Arraras, J. G., Cilla, G., Marco, E., Vidal Garcia, M., Omenaca, M., Ivanciuc, A. E., Lupulescu, E., Lazar, M., Cherciu, C. M., Tecu, C., Mihai, M. E., Nitescu, M., Leca, D., Ceausu, E., Nohynek, H., Ikonen, N., Haveri, A., Gomez, V., Nunes, B., Rodrigues, A. P., Gomes, V., Corte-Real, R., Pocas, J., Peres, M. J., Visekruna Vucina, V., Kaic, B., Novosel, I. P., Petrovic, G., Ferenczi, A., Oroszi, B., Korczynska, M. R., Brydak, L. B., Cieslik-Tarkota, R., Rozwadowska, B., Skolimowska, G., Hulboj, D., Jakubik, A., Meijer, A., Van Gageldonk-Lafeber, A. B., Research Council of Lithuania, and European Union

Subjects
0301 basic medicine, Male, Veterinary medicine, Immunology and Microbiology (all), medicine.disease_cause, Polymerase Chain Reaction, Aged, Aged, 80 and over, Case-Control Studies, Clinical Laboratory Techniques, Europe, Female, Hospitalization, Humans, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype, Influenza B virus, Influenza Vaccines, Influenza, Human, Respiratory Tract Infections, Seasons, Sentinel Surveillance, Vaccination, Molecular Medicine, Veterinary (all), Public Health, Environmental and Occupational Health, Infectious Diseases, Seasonal influenza, IMOVE+, 0302 clinical medicine, 80 and over, Influenza A Virus, Influenza A virus, 030212 general & internal medicine, Respiratory tract infections, virus diseases, 3. Good health, H3N2 Subtype, Public Health, Human, medicine.medical_specialty, Influenza vaccine, 030106 microbiology, Virus, Hospital, 03 medical and health sciences, Repeated Vaccination, Internal medicine, medicine, H1N1 Subtype, Influenza Vaccine Effectiveness, General Veterinary, General Immunology and Microbiology, business.industry, Environmental and Occupational Health, Cuidados de Saúde, Case-control study, Influenza, Negative case, influenza vaccination, test negative case control, vaccine effectiveness, business
Abstract

In Europe, annual influenza vaccination is recommended to elderly. From 2011 to 2014 and in 2015-16, we conducted a multicentre test negative case control study in hospitals of 11 European countries to measure influenza vaccine effectiveness (IVE) against laboratory confirmed hospitalised influenza among people aged ≥65years. We pooled four seasons data to measure IVE by past exposures to influenza vaccination. We swabbed patients admitted for clinical conditions related to influenza with onset of severe acute respiratory infection ≤7days before admission. Cases were patients RT-PCR positive for influenza virus and controls those negative for any influenza virus. We documented seasonal vaccination status for the current season and the two previous seasons. We recruited 5295 patients over the four seasons, including 465A(H1N1)pdm09, 642A(H3N2), 278 B case-patients and 3910 controls. Among patients unvaccinated in both previous two seasons, current seasonal IVE (pooled across seasons) was 30% (95%CI: -35 to 64), 8% (95%CI: -94 to 56) and 33% (95%CI: -43 to 68) against influenza A(H1N1)pdm09, A(H3N2) and B respectively. Among patients vaccinated in both previous seasons, current seasonal IVE (pooled across seasons) was -1% (95%CI: -80 to 43), 37% (95%CI: 7-57) and 43% (95%CI: 1-68) against influenza A(H1N1)pdm09, A(H3N2) and B respectively. Our results suggest that, regardless of patients' recent vaccination history, current seasonal vaccine conferred some protection to vaccinated patients against hospitalisation with influenza A(H3N2) and B. Vaccination of patients already vaccinated in both the past two seasons did not seem to be effective against A(H1N1)pdm09. To better understand the effect of repeated vaccination, engaging in large cohort studies documenting exposures to vaccine and natural infection is needed. The Lithuanian I-MOVE+ study sites were supported by a grant from the Research Council of Lithuania (SEN-03/2015). The IMOVE+ project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 634446. GlaxoSmithKline, Sanofi Pasteur and Sanofi Pasteur MSD financially supported the InNHOVE network. They had no role in study design, data collection, pooled analysis, and publication. We are grateful to all patients, medical staff, study nurses and epidemiologists from the twelve study sites who actively participated in the study. info:eu-repo/semantics/publishedVersion

Published
2017

50. Interim 2017/18 influenza seasonal vaccine effectiveness: Combined results from five European studies

Author

Rondy, M., Kissling, E., Emborg, H. -D., Gherasim, A., Pebody, R., Trebbien, R., Pozo, F., Larrauri, A., Mcmenamin, J., Valenciano, M., Kaic, B., Filipovic, S. K., Visekruna-Vucina, V., Novosel, I. P., Lovric, Z., Petrovic, G., Krause, T. G., Fische, T. K., Lina, B., Falchi, A., Vilcu, A. -M., Souty, C., Blanchon, T., van der Werf, S., Enouf, V., Behillil, S., Valette, M., Bernard-Stoecklin, S., Levy-Bruhl, D., Launay, O., Loulergue, P., Lenzi, N., Lesieur, Z., L'Honneur, A. -S., Galtier, F., Agostini, C., Serrand, C., Merle, C., Foulongne, V., Vanhems, P., Laine, F., Lagathu, G., Carrat, F., Buda, S., Preuss, U., Prahm, K., Schweiger, B., Wedde, M., Heider, A., Martin, M., Biere, B., Duerrwald, R., Domegan, L., Coughlan, L., O'Donnell, J., Joyce, M., Collins, C., Dunford, L., Moran, J., Tuite, G., Duffy, M., Connell, J., de Gascun, C., Rizzo, C., Bella, A., Alfonsi, V., Castrucci, M. R., Puzelli, S., Pagani, E., Ghisetti, V., Pariani, E., Baldanti, F., Palu, G., D'Agaro, P., Ansaldi, F., Affanni, P., Rossolini, G. M., Camilloni, B., Bagnarelli, P., Sanguinetti, Maurizio, Atripaldi, L., Chironna, M., Serra, C., Vitale, F., Germinario, C., Orsi, A., Manini, I., Montomoli, E., Napoli, C., Orsi, G. B., Casado, I., Castilla, J., Fernandino, L., Martinez-Baz, I., Ezpeleta, G., Navascues, A., Perez-Garcia, A., Aguinaga, A., Ezpeleta, C., Meijer, A., van den Brink, S., van der Hoek, W., Goderski, G., Wijsman, L., Bagheri, M., Dijkstra, F., de Lange, M., Marzec, T., Overduin, P., Teirlinck, A., Wentink, E., Donker, G., Marbus, S., van Gageldonk-Lafeber, R., Schneeberger, P., van Oosterheert, J. J., Schweitzer, V., Groeneveld, G., Nunes, B., Machado, A., Rodrigues, A. P., Gomez, V., Kislaya, I., Guiomar, R., Pechirra, P., Cristovao, P., Costa, I., Panarra, A., Corte-Real, R., Pocas, J., Peres, M. J., Comas, L. G., Marisquerena, M. E. I., Galan, J. C., Folgueira, M. D., Carril, F. G., Martinez, R. S., Cilla, G., Cenoz, M. G., Rubio, C. Q., Ochoa, E. M., Blasco, M., Duran, J. G., Vanrell, J. M., Reina, J., Castrillejo, D., Gherasim, A. M., Delgado, C., Oliva, J., Casas, I., Garcia, M., Latorre, M., Beamonte, A. M. M., Sapina, A. M., Amores, M. O., Aizpurua, A., Montes, M., Zakikhany, K., Brytting, M., Wiman, A., Carnahan, A., Warburton, F., Djennad, A., Ellis, J., Andrews, N., Marques, D., Cottrell, S., Reynolds, A., Gunson, R., Galiano, M., Lackenby, A., Robertson, C., O'Doherty, M., Sinnathamby, M., Yonova, I., Moore, C., Sartaj, M., de Lusignan, S., Zambon, M., Moren, A., Penttinen, P., Sanguinetti M. (ORCID:0000-0002-9780-7059), Rondy, M., Kissling, E., Emborg, H. -D., Gherasim, A., Pebody, R., Trebbien, R., Pozo, F., Larrauri, A., Mcmenamin, J., Valenciano, M., Kaic, B., Filipovic, S. K., Visekruna-Vucina, V., Novosel, I. P., Lovric, Z., Petrovic, G., Krause, T. G., Fische, T. K., Lina, B., Falchi, A., Vilcu, A. -M., Souty, C., Blanchon, T., van der Werf, S., Enouf, V., Behillil, S., Valette, M., Bernard-Stoecklin, S., Levy-Bruhl, D., Launay, O., Loulergue, P., Lenzi, N., Lesieur, Z., L'Honneur, A. -S., Galtier, F., Agostini, C., Serrand, C., Merle, C., Foulongne, V., Vanhems, P., Laine, F., Lagathu, G., Carrat, F., Buda, S., Preuss, U., Prahm, K., Schweiger, B., Wedde, M., Heider, A., Martin, M., Biere, B., Duerrwald, R., Domegan, L., Coughlan, L., O'Donnell, J., Joyce, M., Collins, C., Dunford, L., Moran, J., Tuite, G., Duffy, M., Connell, J., de Gascun, C., Rizzo, C., Bella, A., Alfonsi, V., Castrucci, M. R., Puzelli, S., Pagani, E., Ghisetti, V., Pariani, E., Baldanti, F., Palu, G., D'Agaro, P., Ansaldi, F., Affanni, P., Rossolini, G. M., Camilloni, B., Bagnarelli, P., Sanguinetti, Maurizio, Atripaldi, L., Chironna, M., Serra, C., Vitale, F., Germinario, C., Orsi, A., Manini, I., Montomoli, E., Napoli, C., Orsi, G. B., Casado, I., Castilla, J., Fernandino, L., Martinez-Baz, I., Ezpeleta, G., Navascues, A., Perez-Garcia, A., Aguinaga, A., Ezpeleta, C., Meijer, A., van den Brink, S., van der Hoek, W., Goderski, G., Wijsman, L., Bagheri, M., Dijkstra, F., de Lange, M., Marzec, T., Overduin, P., Teirlinck, A., Wentink, E., Donker, G., Marbus, S., van Gageldonk-Lafeber, R., Schneeberger, P., van Oosterheert, J. J., Schweitzer, V., Groeneveld, G., Nunes, B., Machado, A., Rodrigues, A. P., Gomez, V., Kislaya, I., Guiomar, R., Pechirra, P., Cristovao, P., Costa, I., Panarra, A., Corte-Real, R., Pocas, J., Peres, M. J., Comas, L. G., Marisquerena, M. E. I., Galan, J. C., Folgueira, M. D., Carril, F. G., Martinez, R. S., Cilla, G., Cenoz, M. G., Rubio, C. Q., Ochoa, E. M., Blasco, M., Duran, J. G., Vanrell, J. M., Reina, J., Castrillejo, D., Gherasim, A. M., Delgado, C., Oliva, J., Casas, I., Garcia, M., Latorre, M., Beamonte, A. M. M., Sapina, A. M., Amores, M. O., Aizpurua, A., Montes, M., Zakikhany, K., Brytting, M., Wiman, A., Carnahan, A., Warburton, F., Djennad, A., Ellis, J., Andrews, N., Marques, D., Cottrell, S., Reynolds, A., Gunson, R., Galiano, M., Lackenby, A., Robertson, C., O'Doherty, M., Sinnathamby, M., Yonova, I., Moore, C., Sartaj, M., de Lusignan, S., Zambon, M., Moren, A., Penttinen, P., and Sanguinetti M. (ORCID:0000-0002-9780-7059)

Abstract

Between September 2017 and February 2018, influenza A(H1N1)pdm09, A(H3N2) and B viruses (mainly B/Yamagata, not included in 2017/18 trivalent vaccines) co-circulated in Europe. Interim results from five European studies indicate that, in all age groups, 2017/18 influenza vaccine effectiveness was 25 to 52% against any influenza, 55 to 68% against influenza A(H1N1)pdm09, -42 to 7% against influenza A(H3N2) and 36 to 54% against influenza B. 2017/18 influenza vaccine should be promoted where influenza still circulates.

Published
2018

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