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Aiming at the disadvantage that traditional PID controller parameter can't be adjusted online timely, control effect is not ideal, this paper introduces a PID control algorithm based on the BP neural network by melting the regular PID controller and the self-turning learning neural network. The algorithm uses the BP neural network to build system parameter model, is able to track the changes of the controlled object, achieves a higher recognition accuracy. It amends the BP neural network weight coefficients by the BP algorithm, realizes adjustment of the PID parameters online. The results of the simulation show that these formulae has fast convergence high precision, and robustness [ABSTRACT FROM AUTHOR]

Objective: To investigate the clinical, endoscopic and pathological features in primary colorectal non-Hodgkin lymphoma., Methods: Twenty-four cases of primary colorectal non-Hodgkin lymphoma were studied retrospectively., Results: The main clinical symptoms were abdominal pain, abdominal mass, loss of weight, fever, bloody stools and altered bowel habits. There were 6 cases (25.0%) involving two or more lesion sites, including three cases showing continuous skip-distribution from sigmoid colon to ascending colon, one case showing the homologous manifestation from rectum to cecum, one case involving ascending colon and rectum, and the last one involving sigmoid colon and rectum. There were 18 cases involving single lesion site and the caecum was the most frequently affected site (44.4%, 8 cases). The major endoscopic phenotypes were ulcer (39.1%), bossing (43.5%) and infiltrating (17.4%). The major pathology types were diffuse large B-cell lymphoma (11/24, 45.8%), intestinal T-cell lymphoma (8/24, 33.3%), and mucosa-associated lymphoid tissue lymphoma (MALT) (3/24, 12.5%). 2 of 24 cases (8.3%) were not decided. Twenty-one patients were treated surgically, containing fifteen radical excisions, one local excision, four palliative excisions and one exploratory laparotomy. Sixteen postoperative patients accepted CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) or COP (cyclophosphamide, vincristine, prednisone) chemotherapy, and three patients abandoned treatment. Twenty-one patients were followed up and the 5-year survival rate was 37.7%., Conclusion: The clinical features of primary colorectal non-Hodgkin's lymphoma have no specificity. Ulcer and bossing are the two major morphologic manifestations of endoscopic. Diffuse large B-cell lymphoma and intestinal T-cell lymphoma are the main pathological types. Comprehensive treatment of surgery and chemotherapy are effective methods for primary colorectal non-Hodgkin lymphoma.

Background & Objective: Recently, neoadjuvant therapy has attracted more attention, but the influence of preoperative intraarterial infusion chemotherapy (PRAC) combined with radiotherapy on Survivin expression in rectal carcinoma is unclear. This study was to investigate the effect of PRAC or radiotherapy on Survivin, P53, and Bax expression in low rectal cancer., Methods: A total of 60 patients with low rectal carcinoma were randomized into 3 groups: 19 received PRAC combined with preoperative radiotherapy (radiochemotherapy group), 15 received preoperative radiotherapy alone (radiotherapy group), and 26 received operation alone (control group). PRAC was performed using Seldinger technique. Preoperative radiotherapy was performed with a total dose of 20 Gy in 5 days, and superadded 30 Gy after operation. Control group received postoperative radiotherapy with a total dose of 50 Gy. The expression of Survivin, P53, and Bax was examined by immunohistochemistry., Results: After neoadjuvant therapy, there was no significant difference in the positive rates of Survivin, P53, and Bax among the 3 groups. In radiochemotherapy group, the positive rate of Survivin was reduced from 63.16% before neoadjuvant therapy to 26.32% after operation (P<0.05), and the overexpression rate of P53 was reduced from 57.89% to 26.32% (P<0.05). In radiotherapy group, the overexpression rate of Survivin was reduced from 53.33% to 13.33% (P<0.05), but there was no significant change in the positive rate of P53. The positive rate of Bax was slightly increased after operation in above 2 groups. In these 2 groups, the median survival time was significantly longer in the patients with reduced Survivin expression than in those with increased Survivin expression (50.05 months vs. 42.61 months, P<0.01). Survivin expression was not obviously related to Bax and P53 expression (P>0.05)., Conclusion: Neoadjuvant therapy could decrease the levels of P53 and Survivin expression, might enhance the level of Bax expression, and consequently accelerate cancer cell apoptosis and achieve a better short-term curative effect on low rectal cancer.