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17 results on '"Gandhi, Sona"'

13. Drug Delivery Applications of Metal-Organic Frameworks (MOFs)

Author

Gandhi, Sona, Mittal, Ashi, and Roy, Indrajit

Subjects
Medical / Nursing / Pharmacology
Abstract

There has been substantial progress in the field of metal–organic frameworks (MOFs) and their nanoscale counterparts (NMOFs), in recent years. Their exceptional physicochemical properties are being constantly and actively exploited for various applications such as energy harvesting, gas storage, gas separation, catalysis, etc. Due to their porous framework, large surface area, tunability and easy surface functionalization, MOFs and NMOFs have also emerged as useful tools for biomedical applications, specifically for drug delivery. As drug carriers, they offer high drug loading capacity and controlled release at the target site. This chapter aims to give a panorama of the use of these MOFs as drug delivery agents. A brief overview of the structure and composition of MOFs, along with various methods and techniques to synthesize NMOFs suitable for drug delivery applications are mentioned. In addition, the most commonly employed strategies to associate drugs with these NMOFs are highlighted and methods to characterize them are also briefly discussed. The last section summarizes the applications of MOFs and NMOFs as carriers of therapeutic drugs, biomolecules, and other active agents.

Published
2019

16. Do Adjuvant Aromatase Inhibitors Increase the Cardiovascular Risk in Postmenopausal Women With Early Breast Cancer?

Author

Cuppone, Federica, Bria, Emilio, Verma, Sunil, Pritchard, Kathleen I., Gandhi, Sona, Carlini, Paolo, Nisticò, Cecilia, Terzoli, Edmondo, Cognetti, Francesco, and Giannarelli, Diana

Subjects
BREAST cancer, CLINICAL trials, CANCER in women, CANCER patients, TAMOXIFEN, META-analysis, CLINICAL medicine research
Abstract

The article discusses whether adjuvant aromatase inhibitors (AIs) increase the cardiovascular risk in postmenopausal women with early breast cancer. In this review, Phase 3 randomized clinical trials (RCT) comparing AI with tamoxifen in early breast cancer were considered. The results of the meta-analysis showed that the risk of grade 3 and 4 cardiovascular events (CVAE) in patients who were receiving AI was higher compared with the risk in patients who were receiving tamoxifen and the difference reached statistical significance.

Published
2008
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17. Biomedical In Vivo Studies with ORMOSIL Nanoparticles Containing Active Agents.

Author

Gandhi S and Roy I

Subjects
Animals, Biological Availability, Drug Delivery Systems, Female, Fluorescent Dyes chemistry, Iodine Radioisotopes chemistry, Mice, Nanoparticles, Plasmids genetics, Plasmids pharmacokinetics, Siloxanes pharmacokinetics, Brain metabolism, Plasmids administration & dosage, Siloxanes chemistry
Abstract

Organically modified silica (ORMOSIL) nanoparticles have found many biomedical applications and emerged as biocompatible and efficient carriers of diagnostic and therapeutic agents, such as fluorophores, drugs, and DNA. Herein, we describe two major in vivo studies exemplifying the use of these nanoparticles as carriers of active agents. The first part of this report details a systemic administration and biodistribution of radiolabeled and fluorophore-incorporated ORMOSIL nanoparticles in mice. The second part of this report focuses on the use of ORMOSIL nanoparticles as carriers of plasmid DNA for nonviral gene delivery to the mouse brain. We provide detailed protocols describing preparation and characterization of ORMOSIL nanoparticles, methods used for loading the particles with active agents (e.g., radioimaging agents, plasmid DNA), and in vivo administration of the particles.

Published
2020
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