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2. A focus on selected perspectives of the NUMEN project

Author

Cavallaro M., Agodi C., Bellone J. I., Brasolin S., Brischetto G. A., Bussa M. P., Calabrese S., Calvo D., Campajola L., Capirossi V., Cappuzzello F., Carbone D., Ciraldo I., Colonna M., De Benedictis C., De Gregorio G., Delaunay F., Dumitrache F., Ferraresi C., Finocchiaro P., Fisichella M., Gallian S., Gambacurta D., Gandolfo E. M., Gargano A., Giovannini M., Iazzi F., Lanzalone G., Lavagno A., Mereu P., Neri L., Pandola L., Panero R., Persiani R., Pinna F., Russo A. D., Russo G., Santopinto E., Sartirana D., Sgouros O., Sharma V. R., Soukeras V., Spatafora A., Torresi D., Tudisco S., Avanzi L. H., Cardozo E. N., Chinaglia E. F., Costa K. M., Ferreira J. L., Linares R., Lubian J., Masunaga S. H., Medina N. H., Moralles M., Oliveira J. R. B., Santarelli T. M., Santos R. B. B., Guazzelli M. A., Zagatto V. A. B., Koulouris S., Pakou A., Souliotis G., Acosta L., Amador-Valenzuela P., Bijker R., Chavez Lomeli E. R., Garcia-Tecocoatzi H., Huerta Hernandez A., Marin-Lambarri D. J., Vargas Hernandez H., Villagran R. G., Boztosun I., Dapo H., Eke C., Firat S., Hacisalihoglu A., Kucuk Y., Solakci S. O., Yildirim A., Auerbach N., Burrello S., Lenske H., Isaak J., Pietralla N., Werner V., Lay J. A., Petrascu H., Ferretti J., Kotila J., Donaldson L. M., Khumalo T., Neveling R., Pellegri L., Guazzelli, Marcilei Aparecida, Alves Carvalho, Carla Regina, Malheiro, Manuel, Medina, Nilberto Heder, M. Cavallaro, C. Agodi, J.I. Bellone, S. Brasolin, G.A. Brischetto, M.P. Bussa, S. Calabrese, D. Calvo, L. Campajola, V. Capirossi, F. Cappuzzello, D. Carbone, I. Ciraldo, M. Colonna, C. De Benedictis, G. De Gregorio, F. Delaunay, F. Dumitrache, C. Ferraresi, P. Finocchiaro, M. Fisichella, S. Gallian, D. Gambacurta, E.M. Gandolfo, A. Gargano, M. Giovannini, F. Iazzi, G. Lanzalone, A. Lavagno, P. Mereu, L. Neri, L. Pandola, R. Panero, R. Persiani, F. Pinna, A.D. Russo, G. Russo, E. Santopinto, D. Sartirana, O. Sgouros, V.R. Sharma, V. Soukeras, A. Spatafora, D. Torresi, S. Tudisco, L.H. Avanzi, E.N. Cardozo, E.F. Chinaglia, K.M. Costa, J.L. Ferreira, R. Linares, J. Lubian, S. H. Masunaga, N.H. Medina, M. Moralles, J.R.B. Oliveira, T.M. Santarelli, R.B.B. Santos, M.A. Guazzelli, V.A.B. Zagatto, S. Koulouris, A. Pakou, G. Souliotis, L. Acosta, P. Amador-Valenzuela, R. Bijker, E.R. Chávez Lomelí, H. Garcia-Tecocoatzi, A. Huerta Hernandez, D.J. Marín-Lámbarri, H. Vargas Hernandez, R. G. Villagrán, I. Boztosun, H. Dapo, C. Eke, S. Firat, A. Hacisalihoglu, Y. Kucuk, S.O. Solakcı, A. Yildirim, N. Auerbach, S. Burrello, H. Lenske, J. Isaak, N. Pietralla, V. Werner, J.A. Lay, H. Petrascu, J. Ferretti, J. Kotila, L. M. Donaldson, T. Khumalo, R. Neveling, L. Pellegri, Cavallaro, M., Agodi, C., Bellone, J. I., Brasolin, S., Brischetto, G. A., Bussa, M. P., Calabrese, S., Calvo, D., Campajola, L., Capirossi, V., Cappuzzello, F., Carbone, D., Ciraldo, I., Colonna, M., De Benedictis, C., De Gregorio, G., Delaunay, F., Dumitrache, F., Ferraresi, C., Finocchiaro, P., Fisichella, M., Gallian, S., Gambacurta, D., Gandolfo, E. M., Gargano, A., Giovannini, M., Iazzi, F., Lanzalone, G., Lavagno, A., Mereu, P., Neri, L., Pandola, L., Panero, R., Persiani, R., Pinna, F., Russo, A. D., Russo, G., Santopinto, E., Sartirana, D., Sgouros, O., Sharma, V. R., Soukeras, V., Spatafora, A., Torresi, D., Tudisco, S., Avanzi, L. H., Cardozo, E. N., Chinaglia, E. F., Costa, K. M., Ferreira, J. L., Linares, R., Lubian, J., Masunaga, S. H., Medina, N. H., Moralles, M., Oliveira, J. R. B., Santarelli, T. M., Santos, R. B. B., Guazzelli, M. A., Zagatto, V. A. B., Koulouris, S., Pakou, A., Souliotis, G., Acosta, L., Amador-Valenzuela, P., Bijker, R., Chavez Lomeli, E. R., Garcia-Tecocoatzi, H., Huerta Hernandez, A., Marin-Lambarri, D. J., Vargas Hernandez, H., Villagran, R. G., Boztosun, I., Dapo, H., Eke, C., Firat, S., Hacisalihoglu, A., Kucuk, Y., Solakci, S. O., Yildirim, A., Auerbach, N., Burrello, S., Lenske, H., Isaak, J., Pietralla, N., Werner, V., Lay, J. A., Petrascu, H., Ferretti, J., Kotila, J., Donaldson, L. M., Khumalo, T., Neveling, R., and Pellegri, L.

Subjects
History, ydinreaktiot, ilmaisimet, tutkimuslaitteet, ydinfysiikka, Computer Science Applications, Education
Abstract

The use of double charge exchange reactions is discussed in view of their application to extract information that may be helpful to determinate the nuclear matrix elements entering in the expression of neutrinoless double beta decay half-life. The strategy adopted in the experimental campaigns performed at INFN - Laboratori Nazionali del Sud and in the analysis methods within the NUMEN project is briefly described, emphasizing the advantages of the multi-channel approach to nuclear reaction data analysis. An overview on the research and development activities on the MAGNEX magnetic spectrometer is also given, with a focus on the chosen technological solutions for the focal plane detector which will guarantee the performances at high-rate conditions.

Published
2022
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4. Recent results on heavy-ion direct reactions of interest for 0 nu beta beta decay at INFN - LNS

Author

Cavallaro, M. Acosta, L. Adsley, P. Agodi, C. Altana, C. and Amador-Valenzuela, P. Auerbach, N. Barea, J. Bellone, I, J. Bijker, R. Borello-Lewin, T. Boztosun, I Branchina, V and Brasolin, S. Brischetto, G. A. Brunasso, O. Burrello, S. and Campajola, L. Calabrese, S. Calabretta, L. Calvo, D. and Capirossi, V Cappuzzello, F. Carbone, D. Charon Garcia, L. E. Chavez Lomeli, E. R. Chen, R. Ciraldo, I Colonna, M. and Cutuli, M. Delaunay, F. Deshmukh, N. Djapo, H. and Gambacurta, D. De Geronimo, G. De los Rios, K. Eke, C. and Ferraresi, C. Ferreira, J. L. Ferretti, J. Finocchiaro, P. and Firat, S. Fisichella, M. Flechas Garcia, D. C. Foti, A. and Gandolfo, E. Garcia-Tecocoatzi, H. Hacisalihoglu, A. and Huerta-Hernandez, A. Kotila, J. Kucuk, Y. Iazzi, F. and Jivan, H. Lanzalone, G. Lay, J. A. La Fauci, L. La Via, F. Lenske, H. Linares, R. Lubian, J. Ma, J. and Marin-Lambarri, D. Mas Ruiz, J. Medina, N. H. Mendes, D. R. and Mereu, P. Moralles, M. Neri, L. Neveling, R. and Oliveira, J. R. B. Pakou, A. Pandola, L. Pellegri, L. and Petrascu, H. Pietralla, N. Pinna, F. Reito, S. Ries, P. C. Russo, A. D. Russo, G. Santopinto, E. Santos, R. B. B. Serbina, L. Sgouros, O. da Silveira, M. A. G. and Solakci, S. O. Souliotis, G. Soukeras, V Spatafora, A. and Torresi, D. Tudisco, S. Vargas Hernandez, H. Vsevolodovna, R. I. M. Wang, J. Werner, V Yang, Y. Yildirin, A. and Zagatto, V. A. B. NUMEN Collaboration

Abstract

Neutrinoless double beta decay of nuclei, if observed, would have important implications on fundamental physics. In particular it would give access to the effective neutrino mass. In order to extract such information from 0 nu beta beta decay half-life measurements, the knowledge of the Nuclear Matrix Elements (NME) is of utmost importance. In this context the NUMEN and the NURE projects aim to extract information on the NME by measuring cross sections of Double Charge Exchange reactions in selected systems which are expected to spontaneously decay via 0 nu beta beta. In this work an overview of the experimental challenges that NUMEN is facing in order to perform the experiments with accelerated beams and the research and development activity for the planned upgrade of the INFN-LNS facilities is reported.

Published
2020

5. Recent results on heavy-ion direct reactions of interest for 0νββ decay at INFN - LNS

Author

Cavallaro, M., primary, Acosta, L., additional, Adsley, P., additional, Agodi, C., additional, Altana, C., additional, Amador-Valenzuela, P., additional, Auerbach, N., additional, Barea, J., additional, Bellone, J. I., additional, Bijker, R., additional, Borello-Lewin, T., additional, Boztosun, I., additional, Branchina, V., additional, Brasolin, S., additional, Brischetto, G. A., additional, Brunasso, O., additional, Burrello, S., additional, Campajola, L., additional, Calabrese, S., additional, Calabretta, L., additional, Calvo, D., additional, Capirossi, V., additional, Cappuzzello, F., additional, Carbone, D., additional, Charon Garcia, L. E., additional, Chávez Lomeli, E. R., additional, Chen, R., additional, Ciraldo, I., additional, Colonna, M., additional, Cutuli, M., additional, D’Agostino, G., additional, Delaunay, F., additional, Deshmukh, N., additional, Djapo, H., additional, Gambacurta, D., additional, De Geronimo, G., additional, De Los Rìos, K., additional, Eke, C., additional, Ferraresi, C., additional, Ferreira, J. L., additional, Ferretti, J., additional, Finocchiaro, P., additional, Firat, S., additional, Fisichella, M., additional, Flechas Garcia, D.C., additional, Foti, A., additional, Gandolfo, E., additional, Garcia-Tecocoatzi, H., additional, Hacisalihoglu, A., additional, Huerta-Hernandez, A., additional, Kotila, J., additional, Kucuk, Y., additional, Iazzi, F., additional, Jivan, H., additional, Lanzalone, G., additional, Lay, J. A., additional, La Fauci, L., additional, La Via, F., additional, Lenske, H., additional, Linares, R., additional, Lubian, J., additional, Ma, J., additional, Marin-Lámbarri, D., additional, Mas Ruiz, J., additional, Medina, N. H., additional, Mendes, D. R., additional, Mereu, P., additional, Moralles, M., additional, Neri, L., additional, Neveling, R., additional, Oliveira, J. R. B., additional, Pakou, A., additional, Pandola, L., additional, Pellegri, L., additional, Petrascu, H., additional, Pietralla, N., additional, Pinna, F., additional, Reito, S., additional, Ries, P. C., additional, Russo, A. D., additional, Russo, G., additional, Santopinto, E., additional, Santos, R. B. B., additional, Serbina, L., additional, Sgouros, O., additional, da Silveira, M. A. G., additional, Solakci, S. O., additional, Souliotis, G., additional, Soukeras, V., additional, Spatafora, A., additional, Torresi, D., additional, Tudisco, S., additional, Vargas Hernandez, H., additional, Vsevolodovna, R. I. M., additional, Wang, J., additional, Werner, V., additional, Yang, Y., additional, Yildirin, A., additional, and Zagatto, V. A. B., additional

Published
2020
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6. Equianalgesia, opioid switch and opioid association in different clinical settings: a narrative review.

Author

DE IACO, F., MANNAIONI, G., SERRA, S., FINCO, G., SARTORI, S., GANDOLFO, E., SANSONE, P., and MARINANGELI, F.

Abstract

Emergency or postoperative pain often represents an authentic challenge in patients who were already on opioid treatment for chronic pain. Thus, their management requires not only the physician’s ability to treat acute pain, but also competence in switching the opioid that lost efficacy. Different aspects should be considered, such as opioids titration, switching, association and equianalgesia. The objective of this paper is to provide a narrative review, which has been elaborated and discussed among clinicians through an iterative process involving development and review of the draft during two web-based meetings and via email. This expert opinion aims to facilitate the correct opioid use through appropriate practices with a focus on pain treatment in emergency and postoperative pain. Equianalgesia tables were reviewed and integrated by clinicians and researchers with expertise in anesthesia, postoperative medicine, intensive care, emergency medicine pharmacology and addiction medicine. Special populations (liver/kidney failure, elder, pediatric, pregnancy/lactation) are discussed in detail along with other critical scenarios, such as: (i) rapid pain worsening in chronic pain (aggravating pain due to disease progression or tolerance development to analgesic therapy); (ii) acute pain on maintenance treatment; and (iii) pain management of complicated patients in emergency care. Extended and updated equianalgesia tables and conversion rates for 17 different opioid formulations (of 9 different molecules) are presented as follows. Opioids remain the class that best suits clinical needs of emergency and post-operative medicine. However, it should be stressed that equianalgesia can be affected by drug-to-drug interactions and pharmacological imprecision, in a complex field where clinical experience may be the main guiding principle. [ABSTRACT FROM AUTHOR]

Published
2022

16. Effect of dietary supplementation with ultramicronized palmitoylethanolamide in maintaining remission in cats with nonflea hypersensitivity dermatitis: a double‐blind, multicentre, randomized, placebo‐controlled study

Author

Noli, C., della Valle, M. F., Miolo, A., Medori, C., Schievano, C., Balletti, E., Beccati, M., Bomben, L., Cerqua, A., Colombo, S., Cornegliani, L., De Lucia, M., Dedola, C., Di Mattia, D., Di Tommaso, M., Fabbrini, F., Fanton, N., Ferrara, M., Ferrucci, C., Fileccia, I., Fondati, A., Furiani, N., Galeotti, F., Gandolfo, E., Graziano, L., Legnani, S., Luciani, L., Maina, E., Matricoti, I., Mazzieri, M., Monaco, M., Olivieri, L., Ortalda, C., Pandolfi, P., Pappalardo, E., Pellicoro, C., Petrini, B., Rocconi, F., Romano, E., Salvatori, R., Sartori, R., Scarampella, F., Tazzari, A., Vercelli, A., and Zanna, G.

Subjects
Allergy, 040301 veterinary sciences, Visual analogue scale, Placebo-controlled study, Palmitic Acids, Scientific Paper, Cat Diseases, Placebo, law.invention, 0403 veterinary science, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, medicine, Animals, CATS, General Veterinary, business.industry, Anti-Inflammatory Agents, Non-Steroidal, Hypersensitivity Disorders, Multimodal therapy, 04 agricultural and veterinary sciences, medicine.disease, Amides, Methylprednisolone, Ethanolamines, Anesthesia, Dermatitis, Allergic Contact, Dietary Supplements, Cats, business, medicine.drug
Abstract

Background Feline nonflea hypersensitivity dermatitis (NFHD) is a frequent cause of over‐grooming, scratching and skin lesions. Multimodal therapy often is necessary. Hypothesis/Objectives To investigate the efficacy of ultramicronized palmitoylethanolamide (PEA‐um) in maintaining methylprednisolone‐induced remission in NFHD cats. Animals Fifty‐seven NFHD cats with nonseasonal pruritus were enrolled originally, of which 25 completed all study requirements to be eligible for analysis. Methods and materials Cats were randomly assigned to PEA‐um (15 mg/kg per os, once daily; n = 29) or placebo (n = 28) while receiving a 28 day tapering methylprednisolone course. Cats responding favourably to methylprednisolone were then administered only PEA‐um (n = 21) or placebo (n = 23) for another eight weeks, followed by a four week long treatment‐free period. Cats were maintained in the study until relapse or study end, whichever came first. Primary outcome was time to relapse. Secondary outcomes were pruritus Visual Analog Scale (pVAS), SCORing Feline Allergic Dermatitis scale (SCORFAD) and owner Global Assessment Score (GAS). Results Mean relapse time was 40.5 days (±7.8 SE) in PEA‐um treated cats (n = 13) and 22.2 days (±3.7 SE) for placebo (n = 12; P = 0.04). On Day 28, the severity of pruritus was lower in the PEA‐um treated cats compared to placebo (P = 0.03). Mean worsening of pruritus at the final study day was lower in the PEA‐um group compared to placebo (P = 0.04), whereas SCORFAD was not different between groups. Mean owner GAS at the final study day was better in the PEA‐um than the placebo‐treated group (P = 0.05). Conclusion and clinical importance Ultramicronized palmitoylethanolamide could represent an effective and safe option to delay relapse in NFHD cats., Background – Feline nonflea hypersensitivity dermatitis (NFHD) is a frequent cause of over‐grooming, scratching and skin lesions. Multimodal therapy often is necessary. Hypothesis/Objectives – To investigate the efficacy of ultramicronized palmitoylethanolamide (PEA‐um) in maintaining methylprednisolone‐induced remission in NFHD cats. Conclusion and clinical importance – Ultramicronized palmitoylethanolamide could represent an effective and safe option to delay relapse in NFHD cats.

Published
2019
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