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2. Comparison of Patient Health Questionnaire-9, Edinburgh Postnatal Depression Scale and Hospital Anxiety and Depression – Depression subscale scores by administration mode: An individual participant data differential item functioning meta-analysis

Author

Azar, Marleine, Bhandari, Parash Mani, Chiovitti, Matthew J., He, Chen, Imran, Mahrukh, Krishnan, Ankur, Negeri, Zelalem, Neupane, Dipika, Riehm, Kira E., Yan, Xin Wei, Kloda, Lorie A., Henry, Melissa, Ismail, Zahinoor, Loiselle, Carmen G., Mitchell, Nicholas D., Al-Adawi, Samir, Alvarado, Rubén, Amtmann, Dagmar, Arroll, Bruce, Ayalon, Liat, Baradaran, Hamid R., Barnes, Jacqueline, Beck, Kevin R., Beck, Cheryl Tatano, Bernstein, Charles N., Bindt, Carola, Bombardier, Charles H., Boye, Birgitte, Büel-Drabe, Natalie, Buji, Ryna Imma, Bunevicius, Adomas, Butterworth, Peter, Can, Ceyhun, Carter, Gregory, Chagas, Marcos H., Chan, Juliana C.N., Chan, Lai Fong, Chen, Chih-Ken, Chibanda, Dixon, Chorwe-Sungani, Genesis, Clover, Kerrie, Conroy, Ronán M., Conway, Aaron, Conwell, Yeates, Correa, Humberto, Couto, Thiago Castro e, Cukor, Daniel, Daray, Federico M., de Man-van Ginkel, Janneke M., De Souza, Jennifer, Downing, Marina G., Eapen, Valsamma, Fann, Jesse R., Favez, Nicolas, Felice, Ethel, Fellmeth, Gracia, Ferentinos, Panagiotis P., Fernandes, Michelle, Field, Sally, Figueiredo, Barbara, Fischer, Felix H., Fisher, Jane R.W., Flint, Alastair J., Fujimori, Maiko, Fung, Daniel S.S., Gallagher, Pamela, Gandy, Milena, Gelaye, Bizu, Gholizadeh, Leila, Gibson, Lorna J., Goodyear-Smith, Felicity, Grassi, Luigi, Green, Eric P., Greeno, Catherine G., Hall, Brian J., Hantsoo, Liisa, Haroz, Emily E., Härter, Martin, Hegerl, Ulrich, Helle, Nadine, Hernando, Asuncion, Hides, Leanne, Hobfoll, Stevan E., Honikman, Simone, Howard, Louise M., Hyphantis, Thomas, Iglesias-González, Maria, Inagaki, Masatoshi, Jenewein, Josef, Jeon, Hong Jin, Jetté, Nathalie, Julião, Miguel, Kettunen, Pirjo A., Khamseh, Mohammad E., Kiely, Kim M., Kim, Sung-Wan, Kjærgaard, Marie, Kohlhoff, Jane, Kohrt, Brandon A., König, Hans-Helmut, Kozinszky, Zoltán, Kwan, Yunxin, Lamers, Femke, Lara, María Asunción, Leonardou, Angeliki A., Levin-Aspenson, Holly F., Liu, Shen-Ing, Löbner, Margrit, Loosman, Wim L., Lotrakul, Manote, Loureiro, Sonia R., Love, Anthony W., Löwe, Bernd, Luitel, Nagendra P., Lund, Crick, Maes, Michael, Malt, Ulrik F., Marrie, Ruth Ann, Marsh, Laura, Martínez, Pablo, Marx, Brian P., Matsuoka, Yutaka, McGuire, Anthony, Mehnert, Anja, Michopoulos, Ioannis, Sidik, Sherina Mohd, Müller-Nordhorn, Jacqueline, Muramatsu, Kumiko, Radoš, Sandra Nakić, Navarrete, Laura, Nelson, Christian J., Ng, Chong Guan, Nishi, Daisuke, O'Donnell, Meaghan L., O'Rourke, Suzanne J., Osório, Flávia L., Pabst, Alexander, Pasco, Julie A., Pawlby, Susan J., Peceliuniene, Jurate, Pence, Brian W., Persoons, Philippe, Petersen, Inge, Picardi, Angelo, Ponsford, Jennie L., Pugh, Stephanie L., Pulido, Federico, Quinn, Terence J., Quispel, Chantal, Rathod, Sujit D., Reme, Silje E., Reuter, Katrin, Riedel-Heller, Steffi G., Rooney, Alasdair G., Santos, Iná S., Saracino, Rebecca M., Schellekens, Melanie P.J., Schwarzbold, Marcelo L., Cankorur, Vesile Senturk, Shaaban, Juwita, Sharp, Deborah J., Sharpe, Louise, Shinn, Eileen H., Sidebottom, Abbey, Simard, Sébastien, Singer, Susanne, Skalkidou, Alkistis, Smith-Nielsen, Johanne, Spangenberg, Lena, Stafford, Lesley, Stein, Alan, Stewart, Robert C., Strobel, Natalie A., Su, Kuan-Pin, Sultan, Serge, Sundström-Poromaa, Inger, Sung, Sharon C., Suzuki, Keiko, Tadinac, Meri, Tan, Pei Lin Lynnette, Tandon, S. Darius, Taylor-Rowan, Martin, Teixeira, Antonio L., Tendais, Iva, Tiringer, Istvan, Töreki, Annamária, Tran, Thach D., Trevillion, Kylee, Tschorn, Mira, Turner, Alyna, Væver, Mette S., van der Feltz-Cornelis, Christina M., van Heyningen, Thandi, Vega-Dienstmaier, Johann M., Wagner, Michael, Wagner, Lynne I., Wang, Liang-Jen, Wang, Jian Li, Watson, David, Weyerer, Siegfried B., White, Jennifer, Whooley, Mary A., Wiese, Birgitt, Williams, Lana J., Winkley, Kirsty, Wynter, Karen, Yamada, Mitsuhiko, Yonkers, Kimberly A., Zeng, Qing Zhi, Zhang, Yuying, Harel, Daphna, Wu, Yin, Levis, Brooke, Fan, Suiqiong, Sun, Ying, Xu, Mingyao, Rice, Danielle B., Boruff, Jill, Markham, Sarah, Ioannidis, John P.A., Takwoingi, Yemisi, Patten, Scott B., Ziegelstein, Roy C., Cuijpers, Pim, Gilbody, Simon, Vigod, Simone, Akena, Dickens, Benedetti, Andrea, and Thombs, Brett D.

Published
2024
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12. Comparative effectiveness of digital mental healthcare models for adults with epilepsy: A study protocol of a randomized controlled trial.

Author

Gandy, Milena, Coleman, Honor, Cutler, Henry, Jones, Michael P., Karin, Eyal, Kwan, Patrick, Nikpour, Armin, Parratt, Kaitlyn, Rayner, Genevieve, Titov, Nickolai, Todd, Lisa, Seil, Elizabeth, Winton‐Brown, Toby, Wu, Wendy, and Dear, Blake F.

Abstract

Objective: Mental health complaints are prevalent among people with epilepsy, yet there are major barriers that prevent access to psychological care, including high out‐of‐pocket costs and a lack of accessible specialized services. The purpose of the current study is to examine the comparative efficacy, acceptability, cost‐effectiveness, and long‐term outcomes of a digital psychological intervention when delivered under two models of care (i.e., guided vs. unguided) in supporting the mental health and functioning of adults with epilepsy. Method: Approximately 375 participants across Australia will be enrolled. Eligible participants will have a confirmed diagnosis of epilepsy, experience difficulties with their emotional health, be at least 18 years of age, and live in Australia. Participants will be randomized (2:2:1) to receive the Wellbeing Neuro Course, a 10‐week internet‐delivered program, with (i.e., guided) or without guidance by a mental health clinician (i.e., unguided), or be allocated to a treatment‐as‐usual waiting‐list control group. Participants will complete online questionnaires at pre‐, post‐treatment, and 3‐ and 12‐month follow‐up and consent to have their data linked to their medical records to capture healthcare system resource use and costs. Analysis: Primary outcome measures will be symptoms of depression and anxiety. A cost‐utility analysis will be undertaken using the Australian healthcare system perspective and according to current economic evaluation guidelines. Resource use and costs to the healthcare system during the study period will be captured via data linkage to relevant administrative datasets in Australia. Significance: The results of this trial will provide important data concerning the relative outcomes of these different models of care and will inform the integration of digital psychological interventions translation into healthcare services. Ethics and Dissemination: The Human Research Ethics Committee of Macquarie University approved the proposed study (Reference No: 520231325151475). The results will be disseminated through peer‐reviewed publication(s). ANZCTR Trial Registration Number: ACTRN12623001327673. Plain Language Summary: This study seeks to find out if a 10‐week online psychological treatment can improve the mental health and well‐being of Australian adults with epilepsy. Around 375 participants will be randomly assigned to different groups: one will receive treatment with guidance from mental health clinician (guided group), one without guidance (unguided group), and one starting later (waiting control group). All participants will fill out the same outcome measures online. The main goal of this research is to compare these groups and assess how well the treatment works in improving mental health outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Probability of major depression diagnostic classification based on the SCID, CIDI and MINI diagnostic interviews controlling for Hospital Anxiety and Depression Scale – Depression subscale scores: An individual participant data meta-analysis of 73 primary studies

Author

Wu, Yin, Levis, Brooke, Sun, Ying, Krishnan, Ankur, He, Chen, Riehm, Kira E., Rice, Danielle B., Azar, Marleine, Yan, Xin Wei, Neupane, Dipika, Bhandari, Parash Mani, Imran, Mahrukh, Chiovitti, Matthew J., Saadat, Nazanin, Boruff, Jill T., Cuijpers, Pim, Gilbody, Simon, McMillan, Dean, Ioannidis, John P.A., Kloda, Lorie A., Patten, Scott B., Shrier, Ian, Ziegelstein, Roy C., Henry, Melissa, Ismail, Zahinoor, Loiselle, Carmen G., Mitchell, Nicholas D., Tonelli, Marcello, Al-Adawi, Samir, Beraldi, Anna, Braeken, Anna P.B.M., Büel-Drabe, Natalie, Bunevicius, Adomas, Carter, Gregory, Chen, Chih-Ken, Cheung, Gary, Clover, Kerrie, Conroy, Ronán M., Cukor, Daniel, da Rocha e Silva, Carlos E., Dabscheck, Eli, Daray, Federico M., Douven, Elles, Downing, Marina G., Feinstein, Anthony, Ferentinos, Panagiotis P., Fischer, Felix H., Flint, Alastair J., Fujimori, Maiko, Gallagher, Pamela, Gandy, Milena, Goebel, Simone, Grassi, Luigi, Härter, Martin, Jenewein, Josef, Jetté, Nathalie, Julião, Miguel, Kim, Jae-Min, Kim, Sung-Wan, Kjærgaard, Marie, Köhler, Sebastian, Loosman, Wim L., Löwe, Bernd, Martin-Santos, Rocio, Massardo, Loreto, Matsuoka, Yutaka, Mehnert, Anja, Michopoulos, Ioannis, Misery, Laurent, Navines, Ricard, O'Donnell, Meaghan L., Öztürk, Ahmet, Peceliuniene, Jurate, Pintor, Luis, Ponsford, Jennie L., Quinn, Terence J., Reme, Silje E., Reuter, Katrin, Rooney, Alasdair G., Sánchez-González, Roberto, Schwarzbold, Marcelo L., Senturk Cankorur, Vesile, Shaaban, Juwita, Sharpe, Louise, Sharpe, Michael, Simard, Sébastien, Singer, Susanne, Stafford, Lesley, Stone, Jon, Sultan, Serge, Teixeira, Antonio L., Tiringer, Istvan, Turner, Alyna, Walker, Jane, Walterfang, Mark, Wang, Liang-Jen, White, Jennifer, Wong, Dana K., Benedetti, Andrea, and Thombs, Brett D.

Published
2020
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20. Integrated psychological care services within seizure settings: Key components and implementation factors among example services in four ILAE regions: A report by the ILAE Psychiatry Commission

Author

Gandy, Milena, primary, Michaelis, Rosa, additional, Acraman, Jayne, additional, Donald, Kirsten A., additional, Fitzpatrick, Michael, additional, LaFrance, W. Curt, additional, Margolis, Seth A., additional, Modi, Avani C., additional, Reuber, Markus, additional, Tang, Venus, additional, Thayer, Zoe, additional, Verity, Kirsten, additional, Wagner, Janelle L., additional, Wilmshurst, Jo, additional, Whittaker, Sarah, additional, and Munger Clary, Heidi M., additional

Published
2023
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21. The wellbeing neuro course: a randomised controlled trial of an internet-delivered transdiagnostic psychological intervention for adults with neurological disorders.

Author

Gandy, Milena, Heriseanu, Andreea I., Balakumar, Tanya, Karin, Eyal, Walker, Jennie, Hathway, Taylor, Bisby, Madelyne A., Scott, Amelia J., Dudeney, Joanne, Fisher, Alana, Titov, Nickolai, and Dear, Blake F.

Subjects
*EVALUATION of medical care, *ANXIETY treatment, *WELL-being, *STRUCTURAL equation modeling, *NEUROLOGICAL disorders, *CONFIDENCE intervals, *INTERNET, *HEALTH outcome assessment, *RANDOMIZED controlled trials, *COMPARATIVE studies, *QUESTIONNAIRES, *MENTAL depression, *DESCRIPTIVE statistics, *RESEARCH funding, *STATISTICAL sampling, *DATA analysis software, *PSYCHOTHERAPY, *COGNITIVE therapy, *ADULTS
Abstract

Background: Mental health and functional difficulties are highly comorbid across neurological disorders, but supportive care options are limited. This randomised controlled trial assessed the efficacy of a novel transdiagnostic internet-delivered psychological intervention for adults with neurological disorders. Methods: 221 participants with a confirmed diagnosis of epilepsy, multiple sclerosis, Parkinson's disease, or an acquired brain injury were allocated to either an immediate treatment group (n = 115) or treatment-as-usual waitlist control (n = 106). The intervention, the Wellbeing Neuro Course, was delivered online via the eCentreClinic website. The Course includes six lessons, based on cognitive behavioural therapy, delivered over 10 weeks with support from a psychologist via email and telephone. Primary outcomes were symptoms of depression (PHQ-9), anxiety (GAD-7) and disability (WHODAS 2.0). Results: 215 participants commenced the trial (treatment n = 111; control n = 104) and were included in intention-to-treat analysis. At post-treatment, we observed significant between-group differences in depression (PHQ-9; difference = 3.07 [95% CI 2.04–4.11], g = 0.62), anxiety (GAD-7; difference = 1.87 [0.92–2.81], g = 0.41) and disability (WHODAS 2.0 difference = 3.08 [1.09–5.06], g = 0.31), that favoured treatment (all ps < 0.001). Treatment-related effects were maintained at 3-month follow-up. Findings were achieved with minimal clinician time (average of 95.7 min [s.d. = 59.3] per participant), highlighting the public health potential of this approach to care. No adverse treatment events were reported. Conclusions: Internet-delivered psychological interventions could be a suitable model of accessible supportive care for patients with neurological disorders. [ABSTRACT FROM AUTHOR]

Published
2023
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31. The timing and magnitude of symptom improvements during an Internet-delivered transdiagnostic treatment program for anxiety and depression.

Author

Bisby, Madelyne A., primary, Scott, Amelia J., additional, Fisher, Alana, additional, Gandy, Milena, additional, Hathway, Taylor, additional, Heriseanu, Andreea I., additional, Karin, Eyal, additional, Cross, Shane, additional, Staples, Lauren, additional, Titov, Nickolai, additional, and Dear, Blake F., additional

Published
2022
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32. Eligibility Criteria in Internet Treatments for Anxiety

Author

Bisby, Madelyne, Scott, Amelia, Hathaway, Taylor, Heriseanu, Andreea, Karin, Eyal, Dudeney, Joanne, Gandy, Milena, Titov, Nick, and Dear, Blake

Subjects
Mental Disorders, Medicine and Health Sciences, Psychiatry and Psychology
Abstract

This meta-analysis will provide a comprehensive overview of the eligibility criteria commonly implemented in internet treatments for anxiety, as well as the impact of their use on participant engagement and clinical outcomes. Protocol in attached file.

Published
2022
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33. Internet-delivered psychological interventions for chronic pain: A meta-analysis

Author

Gandy, Milena, Dear, Blake, Pang, Sharon, Scott, Amelia, Dudeney, Joanne, Heriseanu, Andreea, Bisby, Madelyne, Karin, Eyal, and Hathway, Taylor

Subjects
cognitive behavior therapy, pain management, internet treatment, Medicine and Health Sciences, FOS: Law, Social and Behavioral Sciences, chronic pain, Law, meta analysis
Abstract

Meta-analysis protocol to assess the efficacy of internet-delivered cognitive-behavioural pain management programs for the management of adults with of chronic pain conditions

Published
2022
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34. 2429 Investigating traumatic encephalopathy syndrome (TES) in retired athletes, military personnel and victims of assault with a history of sustained, repetitive mild traumatic brain injury

Author

Mobbs, Rowena, primary, Brown, Eamon, additional, Batchelor, Jennifer, additional, Stevenson, Richard, additional, Pearce, Alan, additional, Fraser, Clare, additional, Maddren, Michelle, additional, Magnussen, John, additional, Berry, Jamie, additional, Gandy, Milena, additional, Savage, Greg, additional, and Lystad, Reidar, additional

Published
2022
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37. The Timing and Magnitude of Symptom Improvements During an Internet-Delivered Transdiagnostic Treatment Program for Anxiety and Depression.

Author

Bisby, Madelyne A., Scott, Amelia J., Fisher, Alana, Gandy, Milena, Hathway, Taylor, Heriseanu, Andreea I., Karin, Eyal, Cross, Shane, Staples, Lauren, Titov, Nickolai, and Dear, Blake F.

Subjects
TREATMENT programs, GENERALIZED anxiety disorder, MENTAL illness, SYMPTOMS, RANDOMIZED controlled trials, MENTAL depression
Abstract

Objective: In face-to-face treatments, mental health symptoms improve rapidly across the first few treatment sessions, and the pace of improvement slows with additional sessions. Some individuals also report clinically meaningful symptom improvements after only two or three treatment sessions. As the rate of symptom change has been given limited attention within digital treatments, the present study investigated the timing and magnitude of symptom change during an 8-week online treatment for anxiety and depression. Method: Three adult samples were derived from previous randomized controlled trials: generalized anxiety disorder (n = 165), major depression (n = 149), and mixed anxiety/depression (n = 262). Symptom scores were compared between consecutive weeks of treatment, and we examined the proportion of individuals who achieved a ≥25% or ≥50% improvement in symptoms each week. Results: Across all three samples, symptoms improved more rapidly during the first half of treatment compared to the second half of treatment. Within the first 4 weeks, over half of the participants had experienced a ≥25% improvement in symptoms, and approximately a third of participants had experienced a ≥50% improvement in symptoms. This pattern of change was found irrespective of diagnostic status or outcome measure. Conclusions: A substantial number of people who receive internet-delivered treatments appear to experience rapid, large, and clinically significant symptom improvement early in treatment. These findings add to our theoretical understanding of symptom improvements during psychotherapy, and further research investigating the mechanisms of such change will inform the development of more effective treatments. What is the public health significance of this article?: There appears to be a dose–effect response in internet-delivered treatments, such that symptom improvement is more rapid in the early stages of treatment and slows with time. The first few weeks of treatment appear to be associated with rapid and meaningful symptom improvement and signify a window of therapeutic opportunity. [ABSTRACT FROM AUTHOR]

Published
2023
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38. Examining the psychometric properties of brief screening measures of depression and anxiety in chronic pain: The Patient Health Questionnaire 2‐item and Generalized Anxiety Disorder 2‐item

Author

Bisby, Madelyne A., primary, Karin, Eyal, additional, Scott, Amelia J., additional, Dudeney, Joanne, additional, Fisher, Alana, additional, Gandy, Milena, additional, Hathway, Taylor, additional, Heriseanu, Andreea I., additional, Staples, Lauren, additional, Titov, Nickolai, additional, and Dear, Blake F., additional

Published
2022
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39. The Chronic Conditions Course: A Randomised Controlled Trial of an Internet-Delivered Transdiagnostic Psychological Intervention for People with Chronic Health Conditions

Author

Dear, Blake F., primary, Scott, Amelia J., additional, Fogliati, Rhiannon, additional, Gandy, Milena, additional, Karin, Eyal, additional, Dudeney, Joanne, additional, Nielssen, Olav, additional, McDonald, Sarah, additional, Heriseanu, Andreea I., additional, Bisby, Madelyne A., additional, Sharpe, Louise, additional, Jones, Michael P., additional, Ali, Shehzad, additional, and Titov, Nickolai, additional

Published
2022
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41. Cochrane systematic review and meta-analysis of the impact of psychological treatment on health-related quality of life in people with epilepsy: an update by the ILAE Psychology Task Force, highlighting methodological changes

Author

Michaelis, Rosa, additional, Tang, Venus, additional, Nevitt, Sarah J., additional, Wagner, Janelle L., additional, Modi, Avani C., additional, LaFrance Jr, W. Curt, additional, Goldstein, Laura H., additional, Gandy, Milena, additional, Bresnahan, Rebecca, additional, Valente, Kette, additional, Donald, Kirsten A., additional, and Reuber, Markus, additional

Published
2021
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44. Internet-delivered cognitive and behavioural based interventions for adults with chronic pain: a systematic review and meta-analysis of randomized controlled trials.

Author

Gandy, Milena, Pang, Sharon T.Y., Scott, Amelia J., Heriseanu, Andreea I., Bisby, Madelyne A., Dudeney, Joanne, Karin, Eyal, Titov, Nickolai, and Dear, Blake F.

Subjects
*CHRONIC pain treatment, *CHRONIC pain & psychology, *RESEARCH, *CLINICAL trials, *META-analysis, *INTERNET, *RESEARCH methodology, *SYSTEMATIC reviews, *COGNITION, *EVALUATION research, *COMPARATIVE studies, *ACCEPTANCE & commitment therapy
Abstract

Abstract: This study examined the efficacy of internet-delivered cognitive and behavioural interventions for adults with chronic pain AND explored the role of clinical and study characteristics as moderators of treatment effects. PubMed, Embase, PsycINFO, CENTRAL and CINAHL were searched to identify randomized controlled trials published up to October 2021. A meta-analysis of 36 studies (5778 participants) was conducted, which found small effect sizes for interference/disability (Hedges' g = 0.28; 95% confidence interval [CI] 0.21-0.35), depression ( g = 0.43; 95% CI 0.33-0.54), anxiety ( g = 0.32; 95% CI 0.24-0.40), pain intensity ( g = 0.27; 95% CI 0.21-0.33), self-efficacy ( g = 0.39; 95% CI 0.27-0.52) and pain catastrophizing ( g = 0.31; 95% CI 0.22-0.39). Moderator analyses found that interventions which involved clinician guidance had significantly greater effect sizes for interference/disability ( g = 0.38), anxiety ( g = 0.39), and pain intensity ( g = 0.33) compared with those without ( g = 0.16, g = 0.18, and g = 0.20, respectively). Studies using an inactive control had greater effects for depression ( g = 0.46) compared with active control trials ( g = 0.22). No differences were found between treatments based on traditional cognitive behaviour therapy vs acceptance and commitment therapy. Sample size, study year, and overall risk of bias (Cochrane rating) did not consistently moderate treatment effects. Overall, the results support the use of internet-delivered cognitive and behavioural interventions as efficacious and suggest guided interventions are associated with greater clinical gains for several key pain management outcomes. [ABSTRACT FROM AUTHOR]

Published
2022
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48. A Cost-effectiveness Analysis of an Internet-delivered Pain Management Program Delivered With Different Levels of Clinician Support: Results From a Randomised Controlled Trial

Author

Dear, Blake F., primary, Karin, Eyal, additional, Fogliati, Rhiannon, additional, Dudeney, Joanne, additional, Nielssen, Olav, additional, Scott, Amelia J., additional, Gandy, Milena, additional, Bisby, Madelyne A., additional, Heriseanu, Andreea I., additional, Hathway, Taylor, additional, Staples, Lauren, additional, Titov, Nickolai, additional, and Schroeder, Liz, additional

Published
2021
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49. Managing depression and anxiety in people with epilepsy: A survey of epilepsy health professionals by the ILAE Psychology Task Force

Author

Gandy, Milena, primary, Modi, Avani C., additional, Wagner, Janelle L., additional, LaFrance, W. Curt, additional, Reuber, Markus, additional, Tang, Venus, additional, Valente, Kette D., additional, Goldstein, Laura H., additional, Donald, Kirsten A., additional, Rayner, Genevieve, additional, and Michaelis, Rosa, additional

Published
2021
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