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5 results on '"Gangadharan U"'

2. Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain

Author

Bisogno T, Howell F, Williams G, Minassi A, Cascio MG, Ligresti A, Matias I, Schiano-Moriello A, Paul P, Williams EJ, Gangadharan U, Hobbs C, Di Marzo V, and Doherty P.

Subjects
endocannabinoidi, lipasi, diacilgliceroli, lipids (amino acids, peptides, and proteins)
Abstract

Diacylglycerol (DAG) lipase activity is required for axonal growth during development and for retrograde synaptic signaling at mature synapses. This enzyme synthesizes the endocannabinoid 2-arachidonoyl-glycerol (2-AG), and the CB1 cannabinoid receptor is also required for the above responses. We now report on the cloning and enzymatic characterization of the first specific sn-1 DAG lipases. Two closely related genes have been identified and their expression in cells correlated with 2-AG biosynthesis and release. The expression of both enzymes changes from axonal tracts in the embryo to dendritic fields in the adult, and this correlates with the developmental change in requirement for 2-AG synthesis from the pre- to the postsynaptic compartment. This switch provides a possible explanation for a fundamental change in endocannabinoid function during brain development. Identification of these enzymes may offer new therapeutic opportunities for a wide range of disorders.

Published
2003

3. Genetic-mapping and Pathology of the Neuromuscular Disease in Kyphoscoliotic (ky) Mice

Author

UCL, Coulton, GR., Skynner, MJ., Barrett, M., Moss, J., Gangadharan, U., Entwhistle, A., Beckersbleukx, G., Maréchal, Georges, Brown, SDM., Vanmier, P., Mason, RM., UCL, Coulton, GR., Skynner, MJ., Barrett, M., Moss, J., Gangadharan, U., Entwhistle, A., Beckersbleukx, G., Maréchal, Georges, Brown, SDM., Vanmier, P., and Mason, RM.

Published
1994

5. The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos.

Author

Wright E, Hargrave MR, Christiansen J, Cooper L, Kun J, Evans T, Gangadharan U, Greenfield A, and Koopman P

Subjects
Amino Acid Sequence, Animals, Base Sequence, Bone Diseases, Developmental genetics, Chromosome Mapping, DNA, Complementary genetics, Disease Models, Animal, Disorders of Sex Development, Embryonic and Fetal Development genetics, Female, Humans, In Situ Hybridization, Male, Mice, Molecular Sequence Data, Mutation, Pregnancy, SOX9 Transcription Factor, Cartilage embryology, Gene Expression Regulation, Developmental, High Mobility Group Proteins genetics, Transcription Factors genetics
Abstract

Mutations in the human SRY-related gene, SOX9, located on chromosome 17, have recently been associated with the sex reversal and skeletal dysmorphology syndrome, campomelic dysplasia. In order to clarify the role of this gene in skeletal development, we have studied the expression of mouse Sox9 during embryogenesis. Sox9 is expressed predominantly in mesenchymal condensations throughout the embryo before and during the deposition of cartilage, consistent with a primary role in skeletal formation. Interspecific backcross mapping has localized mouse Sox9 to distal chromosome 11. The expression pattern and chromosomal location of Sox9 suggest that it may be the gene defective in the mouse skeletal mutant Tail-short, a potential animal model for campomelic dysplasia.

Published
1995
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