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Your search keyword '"Gantz, Jay A."' showing total 22 results
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22 results on '"Gantz, Jay A."'

1. Sensorineural correlates of failed functional recovery after natural regeneration of vestibular hair cells in adult mice

Author

Jáuregui, Emmanuel J., primary, Scheinman, Kelli L., additional, Bibriesca Mejia, Ingrid K., additional, Pruett, Lindsay, additional, Zaini, Hannah, additional, Finkbeiner, Connor, additional, Phillips, Jonathan A., additional, Gantz, Jay A., additional, Nguyen, Tot Bui, additional, Phillips, James O., additional, and Stone, Jennifer S., additional

Published
2024
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5. Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts

Author

Chong, James J.H., Yang, Xiulan, Don, Creighton W., Minami, Elina, Liu, Yen-Wen, Weyers, Jill J., Mahoney, Jr., William M., Van Biber, Benjamin, Cook, Savannah M., Palpant, Nathan J., Gantz, Jay A., Fugate, James A., Muskheli, Veronica, Gough, G. Michael, Vogel, Keith W., Astley, Cliff A., Hotchkiss, Charlotte E., Baldessari, Audrey, Pabon, Lil, Reinecke, Hans, Gill, Edward A., Nelson, Veronica, Kiem, Hans-Peter, Laflamme, Michael A., and Murry, Charles E.

Subjects
Embryonic stem cells -- Research, Heart cells -- Research, Regeneration (Biology) -- Research, Stem cell research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Pluripotent stem cells provide a potential solution to current epidemic rates of heart failure (1) by providing human cardiomyocytes to support heart regeneration (2). Studies of human embryonic-stem-cell-derived cardiomyocytes (hESC-CMs) in small-animal models have shown favourable effects of this treatment (3-7). However, it remains unknown whether clinical-scale hESC-CM transplantation is feasible, safe or can provide sufficient myocardial regeneration. Here we show that hESC-CMs can be produced at a clinical scale (more than one billion cells per batch) and cryopreserved with good viability. Using a non-human primate model of myocardial ischaemia followed by reperfusion, we show that cryopreservation and intramyocardial delivery of one billion hESC-CMs generates extensive remuscularization of the infarcted heart. The hESC-CMs showed progressive but incomplete maturation over a 3-month period. Grafts were perfused by host vasculature, and electromechanical junctions between graft and host myocytes were present within 2 weeks of engraftment. Importantly, grafts showed regular calcium transients that were synchronized to the host electrocardiogram, indicating electromechanical coupling. In contrast to small-animal models (7),nonfatal ventricular arrhythmias were observed in hESC-CM-engrafted primates. Thus, hESC-CMs can remuscularize substantial amounts of the infarcted monkey heart. Comparable remuscularization of a human heart should be possible, but potential arrhythmic complications need to be overcome., Human pluripotent stem cells have indisputable cardiomyocyte-generating abilities and have been extensively investigated for repair of the injured heart (3,4,6,10). These stem cells are derived either from developing blastocytsts (human [...]

Published
2014

7. Human ES--cell--derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts

Author

Shiba, Yuji, Fernandes, Sarah, Zhu, Wei-Zhong, Filice, Dominic, Muskheli, Veronica, Kim, Jonathan, Palpant, Nathan J., Gantz, Jay, Moyes, Kara White, Reinecke, Hans, Van Biber, Benjamin, Dardas, Todd, Mignone, John L., Izawa, Atsushi, Hanna, Ramy, Viswanathan, Mohan, Gold, Joseph D., Kotlikoff, Michael I., Sarvazyan, Narine, Kay, Matthew W., Murry, Charles E., and Laflamme, Michael A.

Subjects
Embryonic stem cells -- Research, Heart cells -- Research -- Physiological aspects, Arrhythmia -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Transplantation studies in mice and rats have shown that human embryonic-stem-cell-derived cardiomyocytes (hESC-CMs) can improve the function of infarcted hearts (1-3), but two critical issues related to their electrophysiological behaviour [...]

Published
2012

12. Vesicular Glutamatergic Transmission in Noise-Induced Loss and Repair of Cochlear Ribbon Synapses

Author

Kim, Kyunghee X., primary, Payne, Shelby, additional, Yang-Hood, Aizhen, additional, Li, Song-Zhe, additional, Davis, Bethany, additional, Carlquist, Jason, additional, V-Ghaffari, Babak, additional, Gantz, Jay A., additional, Kallogjeri, Dorina, additional, Fitzpatrick, James A.J., additional, Ohlemiller, Kevin K., additional, Hirose, Keiko, additional, and Rutherford, Mark A., additional

Published
2019
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14. Micelles for delivery of nitric oxide

Author

Yun Suk Jo, Vlies, Andre J. van der, Gantz, Jay, Thacher, Tyler N., Antonijevic, Sasa, Cavadini, Simone, Demurtas, Davide, Stergiopulos, Nikolaos, and Hubbell, Jeffrey A.

Subjects
Amines -- Chemical properties, Hydrophobic effect -- Analysis, Nitric oxide -- Chemical properties, Nitric oxide -- Structure, Piperazine -- Chemical properties, Piperazine -- Structure, Chemistry
Abstract

Newly designed block copolymer pro-amphiphiles and amphiphiles which could be used to provide very long-term release of nitric oxide (NO) are presented. The very small NO-loaded micelles which are able to penetrate complex tissue structures such as the arterial media, open up a number of tissue targets to NO-based therapy.

Published
2009

16. Micelles for Delivery of Nitric Oxide

Author

Jo, Yun Suk, primary, van der Vlies, André J., additional, Gantz, Jay, additional, Thacher, Tyler N., additional, Antonijevic, Sasa, additional, Cavadini, Simone, additional, Demurtas, Davide, additional, Stergiopulos, Nikolaos, additional, and Hubbell, Jeffrey A., additional

Published
2009
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20. RAFT homo- and copolymerization of N-acryloyl-morpholine, piperidine, and azocane and their self-assembled structures

Author

Jo, Yun Suk, van der Vlies, André J., Gantz, Jay, Antonijevic, Sasa, Demurtas, Davide, Velluto, Diana, and Hubbell, Jeffrey A.

Subjects
Block-Copolymers, Biological Significance, technology, industry, and agriculture, Fragmentation Chain Transfer, Drug-Delivery, In-Vivo, Transfer Radical Polymerization, Molecular-Weight, Diblock Copolymers, Aqueous-Solutions, Triblock Copolymer
Abstract

We present new polymeric amphiphiles derived from N-acryloyl derivatives of the cyclic secondary amines: morpholine, piperidine, and azocane polymerized by reversible addition -fragmentation transfer (RAFT) polymerization. Both homopolymerization and block copolymerization of N-acryloylmorpholine (AM), N-acryloylpiperidine (AP), and N-acryloylazocane (AH) were carried out. The block copolymeric amphiphiles, poly[(N-acryloylmorpholine)-block-(N-acryloylpiperidine)] (PAM-PAP) and poly[(N-acryloylmorpholine)-block-(N-acryloylazocane)] (PAM-PAH) were investigated, PAM being a hydrophile, and PAP and PAH being hydrophobes. Moreover, to compare PAM as a hydrophilic block with poly(ethylene glycol) (PEG), poly[(ethylene glycol)block-(N-acryloylpiperidine)] (PEG-PAP) was also formed. In all cases, the degree of polymerization was well-controlled and polymers were obtained in monomodal distributions. The macroamphiphile aggregates in water were reproducibly well-formed by dialysis with a size range between 10 and 70 nm as characterized by dynamic light scattering (DLS). The morphology of the aggregates was examined by transmission electron microscopy (TEM). All aggregates formed from PAM-PAP and PAM-PAH series, up to 0.76 and 0.85 hydrophobic weight fraction, respectively, revealed spherical micelles, whereas coexistence of spherical micelles and/or polymersomes was observed from PEG-PAP at a hydrophobic weight fraction of 0.91. From study of copolymer segregation behavior, PEG-PAP and PAM-PAH span the weak segregation region (WSR) as well as the strong segregation region (SSR), whereas PAM-PAP is positioned in the WSR, owing to the greater hydrophobicity of PAH than PAP. PAM yielded similar aggregation results to PEG when copolymerized with hydrophobic blocks. As a model drug, everolimus was loaded in PAM(0.15)-PAH(0.85) micelles. After loading the drug, the micelle hydrodynamic diameter was slightly increased from 43 +/- 0.1 to 52 +/- 1.8 nm. Everolimus was encapsulated with 60 +/- 7.8% of efficiency and was released over 3 wk in PBS (pH 7.4, 10 mM) at 37 degrees C.

21. Letters.

Author

Gallina, Caroline, Gantz, Jay, Elliott, Brad, Capune, Biff, Ford, Dow, and Fliegelman, Scott

Abstract

Several letters to the editor are presented in response to articles in previous issues including "10 Foods You Should Be Eating, Plus 6 to Avoid (Most of the Time)," by Susan Grant in the May 2010 issue, "Training Tip," by Nathan Koch in the May 2010 issue and "Death Before DNF," by Jim Gourley in the May 2010 issue.

Published
2010

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