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345 results on '"Ganz, Robert A."'

3. Long-term Outcomes of Patients Receiving a Magnetic Sphincter Augmentation Device for Gastroesophageal Reflux

Author

Ganz, Robert A., Edmundowicz, Steven A., Taiganides, Paul A., Lipham, John C., Smith, C. Daniel, DeVault, Kenneth R., Horgan, Santiago, Jacobsen, Garth, Luketich, James D., Smith, Christopher C., Schlack-Haerer, Steven C., Kothari, Shanu N., Dunst, Christy M., Watson, Thomas J., Peters, Jeffrey, Oelschlager, Brant K., Perry, Kyle A., Melvin, Scott, Bemelman, Willem A., Smout, André J.P.M., and Dunn, Dan

Published
2016
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8. SOOTHER TRIAL: Observational study of an over-the-counter ointment to heal anal itch

Author

Felemovicius, Isaac, Ganz, Robert A., Saremi, Mohammad, and Christopfel, William

Subjects
General Medicine
Abstract

IntroductionPruritus ani, or rectal or anal itch, is a common perianal disorder that affects ~5% of the population of the developed world. Treatments for this disorder are somewhat limited and include conservative non-medical perianal hygiene care, and topical medical treatments including topical steroids, antibacterial and antifungal agents, and topical anesthetic/analgesics such as lidocaine or capsaicin; astringents and vasoconstrictors such as ephedrine can also be used.MethodsThe study was IRB approved. We assessed the efficacy of a novel, composite, over-the-counter, topical lidocaine ointment that included an epidermal barrier and antimicrobial effect along with the typical lidocaine anesthetizing effect, in a single arm, observational, longitudinal, population of 20 ambulatory pruritus ani patients. Patients applied the ointment twice daily, and were studied for 2 weeks; primary outcomes included time to symptom resolution and clinical exam resolution as measured on a 5-point visual analog scale.ResultsTwenty-nine consecutive patients were screened and 20 patients (12 males; 8 females) were enrolled in the study. Ninety percent of patients achieved 100% symptom resolution by 2 weeks, and most were improved within 72 h of initiating treatment; 95% of patients had a normal visual exam by the 2 week endpoint. There were no significant adverse events attributable to the therapy.ConclusionUse of a novel composite topical lidocaine agent, demonstrated rapid and effective relief of pruritus ani in an ambulatory population. Additional studies are underway.Clinical trial registeredClinicaltrials.gov, identifier NCT05288907.

Published
2022
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10. Consensus Statements for Management of Barrett's Dysplasia and Early-Stage Esophageal Adenocarcinoma, Based on a Delphi Process

Author

Bennett, Cathy, Vakil, Nimish, Bergman, Jacques, Harrison, Rebecca, Odze, Robert, Vieth, Michael, Sanders, Scott, Gay, Laura, Pech, Oliver, Longcroft–Wheaton, Gaius, Romero, Yvonne, Inadomi, John, Tack, Jan, Corley, Douglas A., Manner, Hendrik, Green, Susi, Al Dulaimi, David, Ali, Haythem, Allum, Bill, Anderson, Mark, Curtis, Howard, Falk, Gary, Fennerty, M. Brian, Fullarton, Grant, Krishnadath, Kausilia, Meltzer, Stephen J., Armstrong, David, Ganz, Robert, Cengia, Gianpaolo, Going, James J., Goldblum, John, Gordon, Charles, Grabsch, Heike, Haigh, Chris, Hongo, Michio, Johnston, David, Forbes–Young, Ricky, Kay, Elaine, Kaye, Philip, Lerut, Toni, Lovat, Laurence B., Lundell, Lars, Mairs, Philip, Shimoda, Tadakuza, Spechler, Stuart, Sontag, Stephen, Malfertheiner, Peter, Murray, Iain, Nanji, Manoj, Poller, David, Ragunath, Krish, Regula, Jaroslaw, Cestari, Renzo, Shepherd, Neil, Singh, Rajvinder, Stein, Hubert J., Talley, Nicholas J., Galmiche, Jean–Paul, Tham, Tony C.K., Watson, Peter, Yerian, Lisa, Rugge, Massimo, Rice, Thomas W., Hart, John, Gittens, Stuart, Hewin, David, Hochberger, Juergen, Kahrilas, Peter, Preston, Sean, Sampliner, Richard, Sharma, Prateek, Stuart, Robert, Wang, Kenneth, Waxman, Irving, Abley, Chris, Loft, Duncan, Penman, Ian, Shaheen, Nicholas J., Chak, Amitabh, Davies, Gareth, Dunn, Lorna, Falck–Ytter, Yngve, Decaestecker, John, Bhandari, Pradeep, Ell, Christian, Griffin, S. Michael, Attwood, Stephen, Barr, Hugh, Allen, John, Ferguson, Mark K., Moayyedi, Paul, and Jankowski, Janusz A.Z.

Published
2012
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13. RiskBIM - Risikostyring i BIM-drevne offentlige samferdselsprosjekter

Author

Welte, Thomas Michael, Gustavsen, Morten Andre, Vatn, Jørn, Zhupanova, Liliya, Lillehammer, Grethe, and Ganz, Robert

Abstract

This report summarizes the main results from the RiskBIM project (Risk management for BIM-driven public transport projects) supported by the Norwegian Research Council. RiskBIM dealt with the use of digital models and BIM tools in risk management for transport projects. The overall goal of the project was to improve current work processes, methods, and tools for risk management by exploiting the potential of BIM (Building Information Model), with a special focus on RAMS (Reliability, Availability, Maintainability and Safety) and SHA (Safety, Health, Working Environment). New knowledge in the project was mainly obtained by developing various new innovative concepts within the topic and testing or piloting these in a realistic setting (pilot studies). The RiskBIM-project developed various concepts that can help to utilize BIM for the risk subjects in a better way: • Visualize risk-related information in the BIM model and update this information in BIM • Interaction between design and RAMS in BIM by utilizing a project collaboration tool and linking this to BIM • Integrate and visualize risk from different subjects in maps and models throughout the life cycle of a project • Use the open BIM standard BCF for the exchange of risk-related information • Streamline and automate risk analyses by turning risk models into BIM The concepts were implemented in or connected to BIM (and GIS) through prototype solutions developed in RiskBIM. The solutions were subsequently tested by various project participants through pilot studies with user involvement where it was demonstrated improvements by means of: • Improved visualization of risk factors • User-friendly web-based concept that connects BIM with risks and hazards • Linking risk-related information to BIM, or linking information in BIM to risk models • Use open and free standards RiskBIM had its main focus on the design and construction phase of transport projects, but student work also shed light on the use of BIM in the operation and maintenance phase to explore the opportunities BIM can provide after transport projects have been completed. The studies showed that there are a number of challenges related to BIM in the operations and maintenance phase that either need to be solved in order to use BIM for certain purposes, or require clarification of which alternative tools to use instead of BIM (e.g. GIS, maintenance management systems, etc.).

Published
2022

22. Circumferential ablation of Barrett's esophagus that contains high-grade dysplasia: a U.S. multicenter registry

Author

Ganz, Robert A., Overholt, Bergein F., Sharma, Virender K., Fleischer, David E., Shaheen, Nicholas J., Lightdale, Charles J., Freeman, Stephen R., Pruitt, Ronald E., Urayama, Shiro M., Gress, Frank, Pavey, Darren A., Branch, M. Stanley, Savides, Thomas J., Chang, Kenneth J., Muthusamy, V. Raman, Bohorfoush, Anthony G., Pace, Samuel C., DeMeester, Steven R., Eysselein, Viktor E., Panjehpour, Masoud, and Triadafilopoulos, George

Published
2008
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39. Calcium and colorectal epithelial cell proliferation: a preliminary randomized, double-blinded, placebo-controlled clinical trial

Author

Bostick, Roberd M., Potter, John D., Fosdick, Lisa, Grambsch, Patricia, Lampe, Johanna W., Wood, James R., Louis, Thomas A., Ganz, Robert, and Grandits, Greg

Subjects
Colorectal cancer -- Risk factors, Epithelial cells -- Abnormalities, Cell proliferation -- Physiological aspects, Calcium, Dietary -- Health aspects, Health
Abstract

Background: Colonic epithelial cell proliferation is increased in patients at high risk for colon cancer. Calcium administration has ameliorated the proliferative changes in rodents, and findings in small, uncontrolled clinical trials have suggested similar effects in humans. Purpose: This preliminary, double-blind, randomized clinical trial was designed 1) to investigate whether supplemental calcium will reduce colonic epithelial cell proliferation in patients with sporadic adenomas who consume a high-fat, Western-style diet; 2) to determine the sample size (number of scorable crypts per person) needed to achieve adequate statistical power; and 3) to evaluate the feasibility of full-scale clinical trials. Methods: Twenty-one sporadic adenoma patients were treated daily with placebo or 1200 mg of supplemental calcium. To determine colonic epithelial cell proliferation, we used tritiated thymidine labeling of colon crypt epithelial cells in rectal biopsy specimens and calculated the percentage of labeled cells (labeling index [LI]). Two pathology technician 'readers' independently scored each specimen, and inter-reader reliability was determined. Subjects remained on their usual diet during the study, and intake of calories, calcium, total fat, and vitamin D did not differ substantially among them. We calculated curves for statistical power to determine the number of scorable crypts needed per person for detection of a statistically significant difference (P

Published
1993

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