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Workplace violence in Chinese hospitals has increasingly attracted world attention. This study aimed to describe the characteristics of criminal litigation cases on workplace violence in Chinese hospitals at a national level and explore the influencing factors associated with the severity of workplace violence. A retrospective study was designed to analyse 507 criminal litigation cases on workplace violence in Chinese hospitals, with data extracted from the Chinese court website. The multiple ordered logistic regression model was used to analyse the impact of the potential influencing factors on the severity of workplace violence. The crimes as workplace violence in the hospitals were concentrated in East and Central China (53.9%). The most common clinical specialty involved in workplace violence was Gynecology and Obstetrics (27.8%). The first 4 types of crimes as workplace violence in the hospitals were the crime as picking quarrels and provoking trouble (26.0%), the crime as disrupting public service (20.7%), the crime as intentional injury (19.1%), and the crime as gathering people to disturb public order (15.2%). The severity of crimes as workplace violence in the hospitals was significantly associated with location (OR = 2.569, P  = .013), victim type (policemen or security guards) (OR = 0.495, P  = .005), more than 3 victims (OR = 2.252, P  = .035), perpetrators (patients' family member) (OR = 0.491, P  = .045), previous arrest (OR = 2.113, P  = .024), premeditation (OR = 2.234, P  = .004), and psychiatric disorders (OR = 1.911, P  = .019). The number of the crimes as workplace violence in Chinese hospitals was slightly declining from 2014 to 2020. The severity of crimes as workplace violence in the hospitals was significantly associated with secondary hospitals, more than 3 victims, victim type (policemen or security guards), perpetrators (patients' family member), previous arrest, premeditation, and psychiatric disorders.

Background : N6-methyladenosine (m6A) is one of the most prevalent mRNA modifications in mammals, and it regulates the fate of modified RNA transcripts. In the current study, we aimed to elucidate the role of YTH m6A RNA-binding protein 1 (YTHDF1), a "reader" of m6A modification, in prostate cancer tumorigenesis. Methods : We employed a multi-omics approach to detect the direct target of YTHDF1 upon manipulation of YTHDF1 expression in prostate cancer cells. Expression of YTHDF1 was also evaluated in human prostate tumors and either adjacent or paired normal tissues. Additionally, in vivo tumor growth and metastasis experimental assays were performed to evaluate the role of YTHDF1 in tumorigenesis. Finally, luciferase reporter assays and Chromatin immunoprecipitation (ChIP) were conducted to elucidate the transcriptional regulators of YTHDF1. Results : We demonstrated that polo-like kinase 1 (PLK1) is a direct target of YTHDF1. YTHDF1 facilitated the translation efficiency of PLK1 in an m6A-dependent manner by identifying the m6A-modified PLK1 mRNA and subsequently promoted the hyperactivation of the PI3K/AKT signaling pathway. Moreover, our results indicated that YTHDF1 was upregulated in prostate cancer tissue and that high YTHDF1 expression was associated with adverse prognosis in patients with prostate cancer. Furthermore, upregulation of YTHDF1 promoted prostate cancer tumorigenesis and metastasis in vitro and in vivo. Additionally, dysregulation of ETS transcription factor ELK1 activated the transcription of YTHDF1 by directly binding to its promoter region. Conclusions : Collectively, our findings suggest that the ELK1/YTHDF1/PLK1/PI3K/AKT axis is critical for prostate cancer progression and may serve as a potential therapeutic target for prostate cancer treatment., Competing Interests: Competing Interests: The authors have declared that no competing interest exists., (© The author(s).)