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10. Simultaneous determination of ten components in Dianxiankang Capsules by HPLC QAMS.

Author

GUANG Li-wen, ZHANG Shuang, GAO Xin-lei, and YANG Tian-ming

Subjects
HIGH performance liquid chromatography, GRADIENT elution (Chromatography), CORRECTION factors, LIQUID analysis, COLUMNS
Abstract

Objective: To establish an high performance liquid chromatography-quantitative analysis of multi components by single marker(HPLC-QAMS) method for simultaneous determination of gastrodin, parishin E, parishin B, parishin, tenuifolin, onjisaponin B, methylophiopogonanone A, methylophiopogonanone B, ß-asarone and a asarone in Dianxiankang Capsules. Methods: Waters Symmetry C18 column was used with acetonitrile-0.05 % phosphoric acid solution as mobile phase for gradient elution. Multiwavelength switching detection. The contents of gastrodin, parishin E, parishin B, parishin, onjisaponin B, methylophiopogonanone A, methylophiopogonanone B, ß-asarone and a-asarone were calculated by relative correction factor. At the same time, the contents of 10 components in 12 batches of Dianxiankang Capsules were determined by external standard method (ESM). Results: An HPLC-QAMS method was established tenuifolin as the internal reference substance was established. The relative correction factors of gastrodin, parishin E, parishin B, parishin, onjisaponin B, methylophiopogonanone A, methylophiopogonanone B, ß-asarone and a-asarone were 0.823 8, 0.723 9, 1.022 9, 1.188 1, 0.727 2, 1.310 8, 0.931 4, 0.654 9 and 1.057 2, respectively. The relative correction factors had good repeatability and no significant difference with ESM(P>0.05). Conclusion: HPLC-QAMS can be used for simultaneous determination of multi-index components in Dianxiankang Capsules. [ABSTRACT FROM AUTHOR]

Published
2022

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