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178 results on '"Gao, Xueren"'

3. Bioinformatics and meta-analysis of the clinical significance of RECK expression and its genetic polymorphisms in cancer.

Author

Zhang, Weichao and Gao, Xueren

Abstract

AbstractRECK plays an important role in the development of cancer. The current study focuses on exploring the clinical significance of RECK expression in cancer by mining public data and also evaluating the relationship between genetic polymorphisms of the RECK gene and cancer risk through meta-analysis. The results showed that RECK expression was not only associated with survival prognosis and immune infiltration in many types of cancers, but also with multiple drug sensitivity in pan-cancer. In addition, the RECK rs10814325 polymorphism was also associated with cancer risk under the homozygote comparison model (CC vs. TT: OR = 1.64, 95%CI = 1.03–2.61, p = 0.04) and the recessive genetic model [CC vs. (CT + TT): OR = 1.55, 95%CI = 1.27–1.89, p < 0.01]. In conclusion, these findings suggest that RECK expression levels may serve as a valuable indicator for assessing cancer prognosis in some cancers as well as drug sensitivity in pan-cancer, and its rs10814325 polymorphism may be used to assess cancer risk. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Clinical significance of <italic>BTLA</italic> gene expression and rs1982809 polymorphism in pan-cancer.

Author

Gao, Xueren, Gao, Yichang, Pan, Shiyu, and Yang, Lin

Abstract

AbstractThe association between the B and T lymphocyte attenuator (BTLA) gene rs1982809 polymorphism and cancer susceptibility has been reported, but these findings are inconsistent. In addition to clarifying the relationship between the rs1982809 polymorphism and cancer susceptibility, the current study also explored the clinical significance of BTLA gene expression. The GSCA tool and Stata software were used to explore the association between BTLA gene expression and tumor stage, immune infiltration, survival prognosis, and drug sensitivity for pan-cancer, and the association of BTLA gene rs1982809 polymorphism with cancer susceptibility, respectively. BTLA gene expression was associated not only with the pathologic stages of thyroid carcinoma, skin cutaneous melanoma, and kidney renal clear cell carcinoma, but also with immune infiltration in 33 types of cancers. In addition, BTLA gene expression was linked to survival prognosis in 8 types of cancers and the sensitivity of 255 drugs such as 5-Fluorouracil, docetaxel, and methotrexate. A meta-analysis of 7 relevant studies with 4002 cancer patients and 5278 healthy controls showed that the BTLA gene rs1982809 polymorphism was unrelated to cancer susceptibility under all genetic models. However, a country-based stratification analysis suggested that the rs1982809 polymorphism could reduce cancer susceptibility in Polish and Tunisian populations. In conclusion, BTLA is expected to serve as a prognostic marker and therapeutic target for certain cancers, and the rs1982809 polymorphism is expected to serve as a cancer susceptibility marker in Polish and Tunisian populations. [ABSTRACT FROM AUTHOR]

Published
2023
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7. Supplementary Figure 2 from An Insertion/Deletion Polymorphism within RERT-lncRNA Modulates Hepatocellular Carcinoma Risk

Author

Zhu, Zhansheng, primary, Gao, Xueren, primary, He, Yan, primary, Zhao, Hua, primary, Yu, Qiang, primary, Jiang, Deke, primary, Zhang, Pingzhao, primary, Ma, Xiaopin, primary, Huang, Huixing, primary, Dong, Dong, primary, Wan, Jiao, primary, Gu, Zhenyong, primary, Jiang, Xinghong, primary, Yu, Long, primary, and Gao, Yuzhen, primary

Published
2023
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8. Supplementary Table 2 from An Insertion/Deletion Polymorphism within RERT-lncRNA Modulates Hepatocellular Carcinoma Risk

Author

Zhu, Zhansheng, primary, Gao, Xueren, primary, He, Yan, primary, Zhao, Hua, primary, Yu, Qiang, primary, Jiang, Deke, primary, Zhang, Pingzhao, primary, Ma, Xiaopin, primary, Huang, Huixing, primary, Dong, Dong, primary, Wan, Jiao, primary, Gu, Zhenyong, primary, Jiang, Xinghong, primary, Yu, Long, primary, and Gao, Yuzhen, primary

Published
2023
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9. Supplementary Table 1 from An Insertion/Deletion Polymorphism within RERT-lncRNA Modulates Hepatocellular Carcinoma Risk

Author

Zhu, Zhansheng, primary, Gao, Xueren, primary, He, Yan, primary, Zhao, Hua, primary, Yu, Qiang, primary, Jiang, Deke, primary, Zhang, Pingzhao, primary, Ma, Xiaopin, primary, Huang, Huixing, primary, Dong, Dong, primary, Wan, Jiao, primary, Gu, Zhenyong, primary, Jiang, Xinghong, primary, Yu, Long, primary, and Gao, Yuzhen, primary

Published
2023
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10. Supplementary Figure Legends 1-4 from An Insertion/Deletion Polymorphism within RERT-lncRNA Modulates Hepatocellular Carcinoma Risk

Author

Zhu, Zhansheng, primary, Gao, Xueren, primary, He, Yan, primary, Zhao, Hua, primary, Yu, Qiang, primary, Jiang, Deke, primary, Zhang, Pingzhao, primary, Ma, Xiaopin, primary, Huang, Huixing, primary, Dong, Dong, primary, Wan, Jiao, primary, Gu, Zhenyong, primary, Jiang, Xinghong, primary, Yu, Long, primary, and Gao, Yuzhen, primary

Published
2023
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11. Supplementary Figure 4 from An Insertion/Deletion Polymorphism within RERT-lncRNA Modulates Hepatocellular Carcinoma Risk

Author

Zhu, Zhansheng, primary, Gao, Xueren, primary, He, Yan, primary, Zhao, Hua, primary, Yu, Qiang, primary, Jiang, Deke, primary, Zhang, Pingzhao, primary, Ma, Xiaopin, primary, Huang, Huixing, primary, Dong, Dong, primary, Wan, Jiao, primary, Gu, Zhenyong, primary, Jiang, Xinghong, primary, Yu, Long, primary, and Gao, Yuzhen, primary

Published
2023
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12. Supplementary Figure 1 from An Insertion/Deletion Polymorphism within RERT-lncRNA Modulates Hepatocellular Carcinoma Risk

Author

Zhu, Zhansheng, primary, Gao, Xueren, primary, He, Yan, primary, Zhao, Hua, primary, Yu, Qiang, primary, Jiang, Deke, primary, Zhang, Pingzhao, primary, Ma, Xiaopin, primary, Huang, Huixing, primary, Dong, Dong, primary, Wan, Jiao, primary, Gu, Zhenyong, primary, Jiang, Xinghong, primary, Yu, Long, primary, and Gao, Yuzhen, primary

Published
2023
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13. Supplementary Figure 3 from An Insertion/Deletion Polymorphism within RERT-lncRNA Modulates Hepatocellular Carcinoma Risk

Author

Zhu, Zhansheng, primary, Gao, Xueren, primary, He, Yan, primary, Zhao, Hua, primary, Yu, Qiang, primary, Jiang, Deke, primary, Zhang, Pingzhao, primary, Ma, Xiaopin, primary, Huang, Huixing, primary, Dong, Dong, primary, Wan, Jiao, primary, Gu, Zhenyong, primary, Jiang, Xinghong, primary, Yu, Long, primary, and Gao, Yuzhen, primary

Published
2023
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30. Meta-analysis of the association between MALAT1 rs619586 A>G polymorphism and cancer risk

Author

Sun Yuqi, Ni Wenwen, Gao Xueren, and Wang Xinyu

Subjects
0301 basic medicine, Oncology, medicine.medical_specialty, China, Lung Neoplasms, Adenocarcinoma of Lung, Biochemistry, Polymorphism, Single Nucleotide, Metastasis, polymorphism, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, cancer, Humans, Genetic Predisposition to Disease, Metastasis associated lung adenocarcinoma transcript 1, risk, MALAT1, business.industry, Biochemistry (medical), Liver Neoplasms, Cell Biology, General Medicine, medicine.disease, Long non-coding RNA, 030104 developmental biology, 030220 oncology & carcinogenesis, Meta-analysis, Adenocarcinoma, ethnicity, Cancer risk, business, Meta-Analysis
Abstract

Objective This study aimed to systematically assess the effect of the metastasis associated lung adenocarcinoma transcript 1 ( MALAT1) long noncoding RNA rs619586 polymorphism on cancer risk. Methods We conducted a literature search of the PubMed, Embase, and China National Knowledge Internet databases to identify relevant studies, and calculated the pooled odds ratios (ORs) and 95% confidence intervals (CIs) for the retrieved studies using RevMan software. Results Nine eligible studies including 5968 cases and 7439 controls were included in the meta-analysis. The pooled results showed that MALAT1 rs619586 polymorphism was significantly associated with cancer risk [(AG + GG) vs. AA: OR = 0.88; GG vs. (AG + AA): OR = 0.64; GG vs. AA: OR = 0.63; AG vs. AA: OR = 0.91; G vs. A: OR = 0.87]. However, subgroup analyses based on ethnicity and cancer type showed significant associations between MALAT1 rs619586 polymorphism and cancer risk in Asians and for cancers other than hepatocellular carcinoma, but not for Caucasians and hepatocellular carcinoma. Conclusions MALAT1 rs619586 polymorphism may play a role in cancer risk. However, further studies are needed to confirm these findings.

Published
2020

31. Association between HULC rs7763881 and cancer risk: an updated Meta-analysis.

Author

Gao, Xueren, Yang, Jiaxin, Wang, Dongbo, Zeng, Qinghang, Li, Fangting, Zhou, Sasha, Zhang, Xue, Fan, Chen, Gao, Ziyan, and Zhao, Yining

Subjects
*DISEASE risk factors, *LOCUS (Genetics), *LIVER cancer, *ESOPHAGEAL cancer, *HEPATOCELLULAR carcinoma
Abstract

In recent years, several case-control studies have explored the association between the rs7763881 locus polymorphism of the HULC gene and cancer risk, however, the findings have been inconsistent. Therefore, a meta-analysis was conducted to clarify the association. Relevant case-control studies were obtained from CNKI, Embase, Web of Science and PubMed databases. RevMan software was used to perform data analysis. A total of 8 case-control studies containing 4036 cases and 5286 controls were included in the current meta-analysis. The overall analysis results showed no significant association between the rs7763881 locus polymorphism and cancer risk. However, stratified analysis based on cancer type showed that the rs7763881 locus polymorphism was associated with the decreased risk of hepatocellular cancer, colorectal cancer and esophageal cancer. In conclusion, the current findings suggest that the rs7763881 polymorphic loci located on the HULC gene may serve as a biomarker for determining an individual's risk of hepatocellular cancer, colorectal cancer and esophageal cancer. [ABSTRACT FROM AUTHOR]

Published
2022
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34. High Detection Rate of Copy Number Variations Using Capture Sequencing Data: A Retrospective Study

Author

Sun, Yu, primary, Ye, Xiantao, primary, Fan, Yanjie, primary, Wang, Lili, primary, Luo, Xiaomei, primary, Liu, Huili, primary, Gao, Xueren, primary, Gong, Zhuwen, primary, Wang, Yu, primary, Qiu, Wenjuan, primary, Zhang, Huiwen, primary, Han, Lianshu, primary, Liang, Lili, primary, Ye, Hui, primary, Xiao, Bing, primary, Gu, Xuefan, primary, and Yu, Yongguo, primary

Published
2020
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39. Genetic Diagnostic Evaluation of Trio-Based Whole Exome Sequencing Among Children With Diagnosed or Suspected Autism Spectrum Disorder

Author

Du, Xiujuan, primary, Gao, Xueren, additional, Liu, Xin, additional, Shen, Lixiao, additional, Wang, Kai, additional, Fan, Yanjie, additional, Sun, Yu, additional, Luo, Xiaomei, additional, Liu, Huili, additional, Wang, Lili, additional, Wang, Yu, additional, Gong, Zhuwen, additional, Wang, Jianguo, additional, Yu, Yongguo, additional, and Li, Fei, additional

Published
2018
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41. TIMP-2 G-418C polymorphism and cancer risk: A meta-analysis

Author

Zhang, Shulong, Gao, Xueren, Yang, Jiaojiao, and Ji, Zhenling

Subjects
Cancer -- Risk factors -- Genetic aspects -- Health aspects -- Research, Matrix metalloproteinase inhibitors -- Usage -- Health aspects, Genetic polymorphisms -- Health aspects -- Research, Health
Abstract

Byline: Shulong. Zhang, Xueren. Gao, Jiaojiao. Yang, Zhenling. Ji Purpose: Tissue inhibitor of metalloproteinase-2 (TIMP-2) plays a critical role in human carcinogenesis. However, the association between TIMP-2 G-418C polymorphism and [...]

Published
2015

42. Neuronal PirB Upregulated in Cerebral Ischemia Acts as an Attractive Theranostic Target for Ischemic Stroke

Author

Wang, Jie, primary, Zhang, Ying, additional, Xia, Jing, additional, Cai, Tingting, additional, Du, Jiawei, additional, Chen, Jinpeng, additional, Li, Ping, additional, Shen, Yuqing, additional, Zhang, Aifeng, additional, Fu, Bo, additional, Gao, Xueren, additional, Miao, Fenqin, additional, Zhang, Jianqiong, additional, and Teng, Gaojun, additional

Published
2018
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