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The resonance fluorescence properties in the steady-state regime are investigated for a driven cascaded exciton-biexciton quantum dot coupled to the two-dimensional black phosphorus metasurfaces. It is shown that for the material parameters under consideration, both the elliptic and hyperbolic dispersion patterns of the surface plasmon modes are achievable according to the variation of the carrier concentration. Further study on the Purcell factor indicates unequal enhancements in the spontaneous decay of the orthogonal in-plane dipoles. Motivated by this intriguing phenomenon, we then investigate the steady-state properties of the driven quantum dot, where the populations of the dressed levels are highly tunable by engineering the anisotropy of the surfaces. As a result, the manipulation of the carrier concentration will lead to strong modifications in the resonance fluorescence. Under certain conditions, one can observe the squeezing of two-mode noise spectra with different resonances and polarizations. Although at the expense of declines in the photon-sideband detunings, it is feasible to enhance the two-mode squeezing by gate doping. Our proposal can be easily extended to other hybrid systems containing anisotropic metasurfaces, which are important for the development of quantum information science.

We study the excitation conditions of the supported field modes, as well as the spontaneous decay property of a two-level quantum emitter coupled to photonic structures containing topological insulators (TIs) and left-handed materials. Within the proper field quantization scheme, the spontaneous decay rates of dipoles with different polarizations are expressed in forms of the Green’s functions. We find that in the proposed structure, the variation in the topological magnetoelectric polarizability (TMP) has a deterministic effect on the excitation of different field modes. As the result, the spontaneous decay property of the quantum emitter can be engineered. For a dipole placed in different spatial regions, the spontaneous decay feature indicates a dominant contribution from the waveguide modes, the surface plasmon modes or the free vacuum modes. Moreover, a special kind of the surface plasmon modes displaying asymmetric density of states at the interfaces, becomes legal in the presence of nontrivial TIs. These phenomena manifest the feasibility in controlling dipole emissions via manipulations of the topological magnetoelectric (TME) effect. Our results have potential applications in quantum technologies relied on the accurate control over light-matter interactions.

We theoretically and experimentally investigate the laser-detected magnetic resonance spectra dressed by a radio-frequency magnetic field in F g = 4 of D1 line of cesium atoms. The analytical expression of the transmission spectrum for magnetic resonance dressed by a radio-frequency magnetic field is derived and has substantial agreement with the transmission spectra observed in the experiment. The theoretical prediction of the ratio of the amplitudes of the two sidebands with the detuning is basically consistent with the experimental data, which confirms the validity of the analytical expression. The separation between the two sidebands under resonance shows a highly linear proportion to the amplitude of the dressing field, which may provide a useful scheme for the measurement of radio-frequency magnetic field and magnetic imaging.

The ultrastrongly coupling (USC) system has very important research significance in quantum simulation and quantum computing. In this paper, the ultranarrow spectrum of a circuit QED system with two qubits ultrastrongly coupled to a single-mode cavity is studied. In the regime of USC, the JC model breaks down and the counter-rotating terms in the quantum Rabi Hamiltonian leads to the level anti-crossing in the energy spectrum. Choosing a single-photon driving field at the point of avoided-level crossing, we can get an equivalent four-level dressed state model, in which the dissipation of the two intermediate states is only related to the qubits decay. Due to the electron shelving of these two metastable states, a narrow peak appears in the cavity emission spectrum. Furthermore, we find that the physical origin for the spectral narrowing is the vacuum-induced quantum interference between two transition pathways. And this interference effect couples the slowly decaying incoherent components of the density matrix into the equations of the sidebands. This result provides a possibility for the study of quantum interference effect in the USC system.

We study the dissipative dynamics and the formation of entangled states in a driven cascaded quantum network, where a cascaded double-cavity optomechanical system is coupled to a common unidirectional optical fiber. In terms of two coherent laser fields simultaneously driving the chiral coupling system, the entanglement can be effectively transferred from the light to two nanomechanical resonators (NMRs) through cavity modes based on the completely destructive interference of quantum noise. By adjusting the relative strength ratio of red- and blue-detuned pump lasers, it is found that the two NMRs can be driven into a mixed two-mode Gaussian entangled mechanical state rather than a non-Gaussian entangled dark state or a pure entangled dark state. If the frequency of the NMR is tuned to be much larger than the chiral coupled-cavity-chain damping rate, it is demonstrated that the chiral dissipative cascaded system can always realize one-way Einstein-Podolsky-Rosen (EPR) steering from one mechanical oscillator to the other, while the reverse one-way EPR steering is impossible to obtain, and the reason for achieving asymmetric Gaussian steering is analyzed. Furthermore, a simple one-way EPR steering criterion based on two-photon correlation can be achieved for an arbitrary bipartite Gaussian state under the standard form of EPR steering, and the effect of mechanical thermal noise on the steering is also discussed. Moreover, the present chiral system can be realized with currently available experimental technology; therefore, we hope that it can be very helpful for potential applications in quantum computation and quantum communication.

We have theoretically and experimentally investigated the laser-detected magnetic resonance induced by radio-frequency two-photon processes in ${F}_{g}=4$ of ${D}_{1}$ line of cesium atoms. The effective Hamiltonian for the interaction between the two radio-frequency magnetic fields and sublevels at the ground state of ${F}_{g}=4$ is derived. By appropriately selecting the frequencies of the two radio-frequency fields, the Raman two-photon process and the cascade two-photon process can occur, which induce the magnetic resonance detected through laser transmission spectra. The theoretical calculation results fit well with the experimental data. Our results maybe apply for measuring the high bandwidth radio-frequency magnetic fields in space and studying the magnetic-induction tomography.

The existing photodetectors at home and abroad are generally lack adjustable gain and bandwidth, which makes it difficult to optimize various parameters. A low noise differential photodetector is designed. Its main gain is adjustable in the range of 10k-l0M, bandwidth is adjustable in the range of DC-3Mhz, and compensation amplification gain is adjustable in the range of 1-10. The equivalent noise model of PIN (positive-intrinsic-negative) photodiode and its amplifier circuit is analyzed. The optimal signal-to-noise ratio is 47dB and the minimum resolvable optical power is 1nW. The output voltage amplitude is linear with the input light intensity. When the signal frequency is within 3MHz, the signal can be detected without distortion. While meeting the performance requirements, the adjustable parameters are easy to explore the influence of gain, bandwidth and other factors on the experimental results, which is flexible and easy to be applied and promoted in precision spectroscopy and quantum optics experiments.

Frequency-resolved photon statistics of resonance fluorescence generated from a two-level system driven by a strong laser field and a weak laser field with equal frequencies are studied. The frequency resolution of fluorescent radiation is described by quantum filtering dynamics, which is simulated theoretically by two single-mode quantum optical cavities with tunable frequencies to scan the incident fluorescent radiation. By calculating the two-photon intensity–intensity correlation functions in terms of the cavity modes, we demonstrate that two-color strong correlations of resonance fluorescence can be generated not only between the opposite sidebands, but also between the central band and one of the sidebands: although both sidebands are broadened due to the perturbation of the weak laser field on the strong-field dressed atom. We emphasize that these properties are in contrast to the conventional case of the standard single-atom Mollow triplet. Moreover, if the resonance frequencies of the two filtering cavities are tuned appropriately, broadband two-color strong correlations are predicted, and the physical origin is revealed from the perspective of quantum interference of photon emission dynamics. This can be considered as a feasible scheme for the design of broadband non-classical light sources, and may be beneficial to the quantum precise detection of atomic and molecular dynamics via quantum optical spectroscopy.

The frequency-resolved correlations of the fluorescence emitted by a four-level system in the $J=1/2$ to $J=1/2$ transition driven by a linearly polarized laser field are theoretically investigated. In the cross two-photon correlation of the $\ensuremath{\pi}$ and ${\ensuremath{\sigma}}^{+}$ transitions, we show that VICs can induce the interference of time orderings between the two-photon paths with different dipole moments, which can serve as a good scheme to exhibit the effects of vacuum-induced coherences (VICs). An external magnetic field can cause frequency differences between two-photon paths with different time orderings. When the differences can be distinguished by detectors, the effects of VICs are destroyed and time asymmetry of the two-photon correlations appears due to the reveal of ``which path'' information. However, the which path information can be erased by tuning the filtering frequencies so the perfect interference effects of time orderings and time symmetry are restored.

By constructing a quantum filtering system to synthesize the spectral and spatial properties of stimulated radiation, the directionality of spectrally correlated nonclassical properties of resonance fluorescence from a three-body quantum antenna is investigated. The quantum antenna consists of three two-level quantum emitters, two of which are identical and strongly driven by an external laser field to radiate the collective resonance fluorescence with three distinct spectral components. The collective stimulated radiation is shaped by the remaining auxiliary emitter via its spontaneous emission, which is assumed to be resonant with the higher-frequency spectral component of the two identical emitters. Due to the presence of the auxiliary emitter, highly directional nonclassicality of the spectral correlations can be generated, which is the consequence of the internal interference of the source and the spatial interference of the radiation field. The electric dipole-dipole interaction between the undriven emitter and the dressed two-body radiating source plays a crucial role in breaking the rotational symmetry of nonclassical signals, which is embodied by various photon correlation functions with a frequency-resolved version for different spectral combinations. By correlating the two opposite sidebands, the frequency-resolved intensity-intensity correlation functions can signal highly directional nonclassicality, and the frequency-resolved two-mode entanglement along a specific emission direction can be tested by the frequency-resolved anomalous correlation function. While the directional nonclassical correlations between the central-frequency and the three-body collective higher-frequency components can be identified through the frequency-resolved intensity-field correlation function. These various frequency-resolved correlation functions characterize the spatial asymmetry of nonclassical properties of the collective stimulated radiation from different perspectives, including the particle properties and the quantum coherences of the filtered photons. When the three-body collective higher-frequency sidebands are correlated with the central band and the lower-frequency sideband, respectively, the schemes of using the auxiliary undriven emitter to generate optimal nonclassical correlations with well-defined directions are discussed analytically. In addition, the results obtained from the three-body quantum antenna and a dressed two-body quantum antenna are compared.

The intensity-amplitude correlation functions for a driven cavity QED system with two non-identical atoms are investigated in this paper. With the support of conditional homodyne detection, one can detect the time-dependent intensity-amplitude correlation functions experimentally. We find time-asymmetry in this correlation when the driving field is tuned to be resonant with the two-photon excitation state, which brings non-Gaussian fluctuations. The physical origin of these phenomena is the distinction of the third-order moment based on complete-collapse and partial-collapse, which corresponds to the measuring sequence of the intensity and amplitude. Finally, we also examined the nonclassical features of the system, which always exhibits photon bunching. The squeezing occurs in the region of weak driving and disappears with the increase of driving strength. Hence, a new classical inequality based on the technique of homodyne cross-correlation measurement is introduced to determine the nonclassicality of the non-Gaussian system in the region of unsqueezing.

BACKGROUND: Cytochrome P450 1B1 (CYP1B1) is a key enzyme in its oestrogen metabolism pathway, giving rise to hydroxylation and conjugation. Functionally relevant genetic variants within CYP1B1 may affect the telomere length and subsequently lead to prostate carcinogenesis. METHODS: We evaluated 8 CYP1B1 tag single nucleotide polymorphisms (SNPs) in 1015 men with prostate cancer (PCa) and 1052 cancer-free controls, and calculated odds ratios (ORs) and 95% confidence intervals (CIs) to estimate their association with risk of PCa. The influence of CYP1B1 SNPs on the relative telomere lengths was then appraised in peripheral blood leukocytes using real-time PCR. RESULTS:CYP1B1 rs1056836 variant was associated with decreased risk of PCa [odds ratio (OR): 0.80; 95% confidence interval (CI): 0.68-0.99, P = 0.041]. Longer telomere length showed a significantly higher proportion of the CYP1B1 rs1056836 CG/GG genotypes, compared with that of the CC genotype (OR: 1.60, 95% CI: 1.04-2.45). CONCLUSION: Our findings suggest that genetic variants within CYP1B1 may confer genetic susceptibility to PCa by altering telomere length.

Chemokines are involved in many aspects of oncogenesis, including regulation of cancer cell growth, dissemination and host-tumor response. However, the potential of the chemokine receptors, CXCR4 and CXCR7, in serving as biomarkers in extramammary Paget's disease (EMPD) has been rarely examined. Expressions of CXCR4 and CXCR7 were evaluated in 92 EMPD specimens by immunohistochemistry. High expression of CXCR4 and CXCR7 were both correlated with regional lymph node metastasis and presence of lymphovascular invasion. High expression of CXCR7 also correlated with the depth of invasion. The prognostic value of these two chemokines were also investigated in progression-free survival (PFS) and cancer-specific survival (CSS). Both high expression of CXCR4 and CXCR7 were indicative of shorter PFS and CSS. In the combined prognostic model, concomitant high expression of CXCR4 and CXCR7 were suggestive of poor prognosis compared with the other two groups. In the multivariate analysis, depth of invasion, combined prognostic model and regional lymph node metastasis at diagnosis were the independent prognostic factors for EMPD patients for PFS, and the former two factors independently impacted CSS. Our results demonstrated that CXCR4 and CXCR7 can be used as prognostic biomarkers and prediction of aggressiveness of EMPD. Therapy targeting CXCR4 and CXCR7 may helpful to prevent EMPD progression and improve the prognosis of EMPD.

We propose and demonstrate a standard form of Einstein-Podolsky-Rosen (EPR) steering for an arbitrary bipartite Gaussian state under which a simple EPR steering criterion for two-photon correlation can be achieved. In terms of a beam splitter preparing three different steerable states, we further test that the simplified criterion is reliable and efficient when it is used to determine whether an arbitrary bipartite Gaussian state is steerable or not. Based on the same theoretical framework, the standard form and criterion of entanglement are reconstructed and discussed. Furthermore, it is found that EPR steering requires stronger two-photon correlation than entanglement, while its direction is strictly dependent on the mean photon number of two light modes. Moreover, the inherent asymmetric feature can be intuitively embodied in the corresponding criteria, and the essential difference and inherent relation between two standard forms is revealed. We hope the present results could be helpful for potential applications in quantum information processing.

Frequency-resolved quantum correlation of resonance fluorescence is investigated in a two-atom radiating system. In this quantum radiating system, only one atom is driven by a laser field, and the spontaneous transition of the undriven atom resonates with one of the Rabi sidebands of the driven atom. A single-mode empty cavity is applied to serve as a Lorentzian filter to output the superbunched fluorescent photon pairs when its frequency is tuned to halfway between the central peak and one of the side peaks. In the case of large filter width, two-photon correlation signal and its physical correspondence can be bridged analytically in our approach. It reveals that this superbunching effect turns out to be the constructive quantum interference between a pair of coupled two-photon cascaded transitions. Ulteriorly, it is the consequence of the modulations of the unfiltered dressed-state transition amplitudes by the filter. Our analytical formalism also shows that, although the dipole-dipole interaction is usually weak, the interatomic coherence caused by this weak perturbation can also play a crucial role in breaking through the superbunching limit obtained from a single two-level atom in the same parameter regime. In addition to being a treasurable quantum pump to probe into the target quantum system, it is also found in our investigation that this superbunched fluorescence can serve as a promising quantum response in detecting this weak perturbation in the interior of the quantum source. A general case is also considered when the two-atom radiating system is monitored by two filter-detector monitoring systems. It is found that this filtered strong quantum correlation can be maintained even though the two photons are spatially separated.

We investigate the absorption spectra for the ${F}_{g}=1\ensuremath{\rightarrow}{F}_{e}=0$ transition of the ${D}_{2}$ line of $^{87}\mathrm{Rb}$ excited by a linearly polarized light in the presence of a transverse magnetic field (TMF) in different directions. Using the theoretical methods in quantum optics, we obtain the analytical expressions for the atomic density-matrix elements and the absorption spectrum. We analyze the splitting proportional to the magnitude of the TMF in the coherent population trapping absorption spectrum and explain its physical origin. Then, the sensitivity of the resonance signal to the phase (in our case, to the angle between the TMF and the light polarization) is investigated. We show and explain the splitting of the bright resonance and find the simple dependence of the separation of this splitting on the magnitude and the direction of the TMF. Therefore, this system may provide a possible method for the measurement of the magnetic field vector. In addition, we study the coherence of the system based on an observable coherence measure, namely, robustness of coherence (ROC). We find that in the case where the absorption signal becomes difficult to detect, the change of the ROC spectrum becomes more obvious and the extreme points are well maintained. Therefore, this may provide a scheme for the measurement of the magnetic field which is complementary to that based on the absorption signal of the laser.

In this paper, we propose a feasible scheme for generating the Schr\"{o}dinger cat states of a macroscopic mechanical resonator in pulsed cavity optomechanics. Starting with cooling the mechanical oscillator to its ground state, a red and a blue pulses with different powers are simultaneously employed to drive the cavity to achieve squeezed mechanical states. Subsequently, a second red pulse is utilized to generate the macroscopic mechanical quantum superpositions, conditioned on the detection of cavity output photons. Finally, after being stored in the resonator for a period of time, the mechanical state is mapped, with a third red pulse, to the cavity output field used for state verification. Our approach is generic and can also be used to produce other kinds of non-Gaussian mechanical states, like optical-catalysis nonclassical states., Comment: 6 pages,4 figures

This study investigated the clinical activity of abiraterone plus prednisone in docetaxel-naive and docetaxel-resistant Chinese patients with metastatic castration-resistant prostate cancer (mCRPC). A total of 146 patients with docetaxel-naive group (103 cases) and docetaxel-resistant group (43 cases) were enrolled from the Shanghai Cancer Center (Shanghai, China) in this retrospective cohort study. The efficacy endpoints were prostate-specific antigen response rate, prostate-specific antigen progression-free survival, clinical/radiographic progression-free survival, and overall survival in response to abiraterone plus prednisone. Significantly higher prostate-specific antigen response rate was found in docetaxel-naive group (54.4%, 56/103) compared to docetaxel-resistant group (34.9%, 15/43) (P = 0.047). In addition, significantly higher median prostate-specific antigen progression-free survival (14.0 vs 7.7 months, P = 0.005), clinical or radiographic progression-free survival (17.0 vs 12.5 months, P = 0.003), and overall survival (27.0 vs 18.0 months, P = 0.016) were found in docetaxel-naive group compared to docetaxel-resistant group, respectively. The univariate and multivariate analyses indicated that lower albumin and visceral metastases were independent significant predictors for shorter overall survival. To sum up, our data suggested that abiraterone plus prednisone was efficient in both docetaxel-naive and docetaxel-resistant Chinese patients. Moreover, higher PSA response rate and longer overall survival were observed in the docetaxel-naive group, which suggested that abiraterone was more effective for docetaxel- naive patients than for docetaxel failures.

Objectives To identify biomarkers that predict the response to standard androgen deprivation therapy (ADT) of patients newly diagnosed with metastatic castration-sensitive prostate cancer (CSPC) in order to improve therapeutic decision-making, and to investigate whether the characterization of baseline circulating tumour cells (CTCs) would predict the effective period of standard ADT. Materials and methods The study included 108 patients newly diagnosed with high-volume metastatic CSPC. Enumeration and characterization of patients' baseline CTCs (CTCs+ and CTCs-, indicating detectable and undetectable CTCs, respectively) were performed using the CanPatrol technique, which detects markers of the epithelial to mesenchymal transition (EMT) in CTCs, and classifies CTCs into epithelial, biophenotypic and mesenchymal phenotypes. Results After a median follow-up of 24 months, 90 patients (83.3%) progressed to castration-resistant prostate cancer (CRPC), 93 patients (86.1%) had detectable CTCs, and the median number of CTCs was 4. The rate of progression to CRPC was significantly higher for patients with mesenchymal CTCs+ than for patients with CTCs+/mesenchymal CTCs- and CTCs- (93.1% vs 71.4% and 73.3%; P = 0.013). The median time to CRPC for patients with mesenchymal CTCs+ was significantly shorter than for those with CTCs+/mesenchymal CTCs- and CTCs- (10.5 months vs 18.0 and 14.0 months; P = 0.003). Multivariate Cox regression analysis suggested that the CTC phenotype was the only independent prognostic factor influencing the progression of disease from CSPC to CRPC. Conclusions Characterization of baseline CTCs according to the EMT phenotype predicted the effective period of standard ADT for patients newly diagnosed with metastatic CSPC. These findings are important for counselling patients and designing clinical trials.

The weak-value-amplification technique has shown great importance in the measurement of tiny physical effects. Here we introduce a polarization-dependent angular velocity measurement system consisting of two Glan prisms and a true zero-order half-wave plate, where a non-Fourier-limited Gaussian pulse acts as the meter. The angular velocities measurements results agree well with theoretical predictions, and its uncertainties are bounded by the Cramér–Rao bound. We also investigate uncertainties of angular velocities for different numbers of detected photons and the smallest reliable postselection probability, which can reach 3.42 ∗ 10 − 6 .

Weak value amplification has shown its superiority in measurement of small physical effects. Here we introduce a signal-recycled weak-value-based velocity measurement strategy to decrease the attenuation of detected photons during the post-selection. Like the power-recycled scheme, we can improve the number of detected photons and signal-to-noise ratio of velocity by forming a cavity. However, optimal improvements of number of detected photons and signal-to-noise ratio cannot be obtained simultaneously in our signal-recycled scheme owing to the walk-off effect. Furthermore, we find that the reflected light is relatively strong compared with the power-recycled scheme, which may increase the collection-detection efficiency in prospective relevant experiment.

We present a theoretical study of double-resonance alignment magnetometers using linearly polarized light, in which the effect of atomic high-order multipole moments is considered. Starting from the effective master equation of our system obtained by eliminating the excited state adiabatically, we derive the full evolution equations of the atomic multipole moments. The analytic solutions of resonance signals involving the four-order multipole moments effect are obtained by using the perturbation approach. We present that the four-order multipole moments effect is negligible in the weak laser field, and the results reduce to that obtained by a three-step approach. However, the role of four-order multipole moments coupled by two-order tensor moments is more significant with the increasing Rabi frequency of light, which cannot be ignored. Meanwhile, the analytic expressions of relaxation processes are also studied, which are a linear combination of the laser-induced equivalent relaxation rate Γ L and the spin-exchange collision rate Γ g . The expected domain of validity of the three-step approach on light power is roughly given by Γ L < 1 2 Γ g . In addition, the steady-state results of resonance signals are presented in a strong radio-frequency magnetic field; in that case, the physical mechanism of the splitting of resonance signals is discussed. These results are valid for arbitrary light power and for an arbitrarily oriented static magnetic field.

Multifold wave-particle quantum correlations are studied in strongly correlated three-photon emissions from the Mollow triplet via frequency engineering. The nonclassicality and the non-Gaussianity of the filtered field are discussed by correlating intensity signal and correlated balanced homodyne signals. Due to the non-Gaussian fluctuations in the Mollow triplet, new forms of the criterion of nonclassicality for non-Gaussian radiation are proposed by introducing intensity-dual quadrature correlation functions, which contain the information about strongly correlated three-photon emissions of the Mollow triplet. In addition, the time-dependent dynamics of non-Gaussian fluctuations of the filtered field is studied, which displays conspicuous asymmetry. Physically, the asymmetrical evolution of non-Gaussian fluctuations can be attributed to the different transition dynamics of the laser-dressed quantum emitter revealed by the past quantum state and conditional quantum state. Compared with the conventional three-photon intensity correlations that unilaterally reflect the particle properties of radiation, the multifold wave-particle correlation functions we proposed may convey more information about wave-particle duality of radiation, such as the quantum coherence of photon triplet and “which-path” in cascaded photon emissions in atomic systems.

The weak-value-amplification technique has been shown to be advantageous for precision metrology. Previous weak-value-based applications have used only a small fraction of data while discarding the rest during post-selection. Here we consider the use of the power-recycling technique to improve the sensitivity of an interferometric weak-value-based velocity measurement scheme. We discuss ways to realize this idea by introducing a power recycling mirror to make the Michelson interferometer a resonant optical cavity. In our analysis, the signal is well enhanced by the cavity and corresponding SNR is also improved although the temporal walk-off effect exits.

We demonstrate a simple technique to lock the frequency of a laser to an atomic transition with a new technique of subnatural linewidth spectroscopy. The coupled rubidium system exhibits an enhanced absorption spectrum of the probe beam with a subnatural linewidth. Compared with other techniques with an additional laser, our scheme only utilizes a single laser, which will be locked. The observed spectroscopic linewidth is down to about 3.5 MHz. The laser frequency fluctuation is about 226 kHz after locking on. The demonstrated scheme offers a convenient and low-cost technique for laser frequency stabilization and related precision measurements.

A DC current sensor based on an optically pumped atomic magnetometer is proposed. It has a high linearity in a wide operation range, since the magnetometer measures the absolute magnitude of the magnetic field produced by the current to be measured. The current sensor exhibits a high accuracy with a non-moment solenoid and magnetic shielding to suppress the influence from the environment. The absolute error of the measured current is below 0.08 mA when the range is from 7.5 mA to 750 mA. The relative error is 5.54 × 10−5 at 750 mA.

Frequency-resolved correlation (FRC) is investigated in fluorescent emission radiated from a $\mathrm{\ensuremath{\Lambda}}$-type atomic system by employing weak coupling regime between quantum emitter and cavities, in which each cavity substituting a Lorentzian filter is assumed to pass through only one fluorescent photon at a time so that the analytical discussions for time orderings can be carried out in a truncated Hilbert space with single-excitation state for each cavity mode. In the limit of bad cavity (large passband width of filter) and short delay, the conditional time ordering amplitudes are introduced with the help of conditioned dressed atom-photon states prepared by preselection to probe into the effect of preferential screening for time orderings of filter-detector systems. Meanwhile, the past quantum state formalism is also applied in FRC to further excavate their collective monitoring effect. Based on the obtained two-mode correlation signals, it is found that, in nonresonant two-photon cascaded processes, bunching and antibunching can appear in two opposite detection orderings, respectively, and can be switched. The physical origin is explored that the two different transition amplitudes of emitted photons from a common spectral band of resonance fluorescence are responsible for opposite time orderings, thus, the imbalance between two complementary time orderings can be enhanced, which is impossible to achieve in resonance fluorescence of two-level atoms. This mechanism is embodied in the conditional time ordering amplitudes produced by this detection theory of cavity modes.

Within the framework of macroscopic quantum electrodynamics, we investigate both the radiation force and the potential of Casimir-Polder type acting on an excited cold two-level atom in a cavity made of left-handed materials and topological insulators. As the time-reversal symmetry is broken on the surface of the topological insulators, the spontaneous emission of the atom placed near the focus point(s) exhibits anisotropic properties. While the potential wells are normally shallow for topological trivial dielectric, they may be amplified in the presence of topological magnetoelectric effect. We find that when there exists only one focus point in the cavity, it is possible to boost the forces or the potential wells by up to one order of magnitude. Meanwhile, the lifetime of the atom could be prolonged owing to the focus effect of the left-handed materials, where the emitted photons can trace back to the atom and reabsorbed by itself. Our results indicate the possibility in forming long-lived potential wells, which may have potential applications in trapping and guiding cold atoms far away from the surface.

Coherent perfect absorption (CPA) is investigated in the quantum nonlinear regime of cavity quantum electrodynamics (CQED), in which a single two-level atom couples to a single-mode cavity weakly driven by two identical laser fields. In the strong-coupling regime and due to the photon blockade effect, the weakly driven CQED system can be described as a quantum system with three polariton states. CPA is achieved at a critical input field strength when the frequency of the input fields matches the polariton transition frequency. In the quantum nonlinear regime, the incoherent dissipation processes such as atomic and photon decays place a lower bound for the purity of the intracavity quantum field. Our results show that under the CPA condition, the intracavity field always exhibits the quadrature squeezing property manifested by the quantum nonlinearity, and the outgoing photon flux displays the super-Poissonian distribution.

The penetration of mobile phones is nearly saturated in both developing and developed regions. In such a circumstance, how to prevent subscriber churn has become an important issue for today’s telecom operators, as the cost to acquire a new subscriber is much higher than that to retain an existing subscriber. In this paper, we propose to leverage the power of big data to mitigate the problem of subscriber churn and enhance the service quality of telecom operators. As the information hub, telecom operators have accumulated a huge volume of valuable data on subscriber behaviors, service usage, and network operations. To enable efficient big data processing, we first build a dedicated distributed cloud infrastructure that integrates both online and offline processing capabilities. Second, we develop a complete churn analysis model based on deep data mining techniques, and utilize inter-subscriber influence to improve prediction accuracy. Finally, we use real datasets obtained from a large telecom operator in China to verify the accuracy of our churn analysis models. The dataset contains the information of over 3.5 million subscribers, which generate over 600 million call detail records (CDRs) per month. The empirical results demonstrate that our proposed method can achieve around 90% accuracy for T + 1 testing periods and identify subscribers with high negative influence successfully.

In this paper, we propose a scheme to generate an entangled state between two spatially separated movable mirrors by injecting the two-mode squeezed optical reservoir to the dissipative optomechanics, in which the movable mirrors can modulate the linewidth of the cavity modes. When the coupling between the mirrors and the corresponding cavity modes is weak, the two driven cavity fields can respectively behave as the squeezed-vacuum reservoir for the two movable mirrors by utilizing the effect of completely destructive interference of quantum noise. Thus the mechanical modes are prepared in a two-mode squeezed vacuum state. Moreover, when the coupling between the two mirrors and the cavities modes is strong, the entanglement between the two movable mirrors decreases because photonic excitation can preclude the completely destructive interference of quantum noise, but the movable mirrors are still entangled.

Greenberger-Horne-Zeilinger (GHZ) and cluster states are two typical kinds of multipartite entangled states and can respectively be used for realizing quantum networks and one-way computation. We propose a feasible scheme for generating Gaussian GHZ and cluster states of multiple mechanical oscillators by pulsed cavity optomechanics. In our scheme, each optomechanical cavity is driven by a blue-detuned pulse to establish quantum steerable correlations between the cavity output field and the mechanical oscillator, and the cavity outputs are combined at a beam-splitter array with given transmissivity and reflectivity for each beam splitter. We show that by harnessing the light-mechanical steerable correlations, the mechanical GHZ and cluster states can be realized via homodyne detection on the amplitude and phase quadratures of the output fields from the beam-splitter array. These achieved mechanical entangled states can be viewed as the output states of an effective mechanical beam-splitter array with the mechanical inputs prepared in squeezed states with the light-mechanical steering. The effects of detection efficiency and thermal noise on the achieved mechanical states are investigated. The present scheme does not require externally injected squeezing and it can also be applicable to other systems such as light-atomic-ensemble interface, apart from optomechanical systems.

BACKGROUND: Cytochrome P450 1B1 (CYP1B1) is a key enzyme in its oestrogen metabolism pathway, giving rise to hydroxylation and conjugation. Functionally relevant genetic variants within CYP1B1 may affect the telomere length and subsequently lead to prostate carcinogenesis. METHODS: We evaluated 8 CYP1B1 tag single nucleotide polymorphisms (SNPs) in 1015 men with prostate cancer (PCa) and 1052 cancer-free controls, and calculated odds ratios (ORs) and 95% confidence intervals (CIs) to estimate their association with risk of PCa. The influence of CYP1B1 SNPs on the relative telomere lengths was then appraised in peripheral blood leukocytes using real-time PCR. RESULTS: CYP1B1 rs1056836 variant was associated with decreased risk of PCa [odds ratio (OR): 0.80; 95% confidence interval (CI): 0.68-0.99, P = 0.041]. Longer telomere length showed a significantly higher proportion of the CYP1B1 rs1056836 CG/GG genotypes, compared with that of the CC genotype (OR: 1.60, 95% CI: 1.04-2.45). CONCLUSION: Our findings suggest that genetic variants within CYP1B1 may confer genetic susceptibility to PCa by altering telomere length.

The dynamics of two two-level atoms embedded near to the interface of paired metamaterial slabs, one of negative permeability and the other of negative permittivity are studied. The interface behaves as a plasmonic waveguide composed of surface-plasmon polariton modes. It is found that significantly different dynamics occur for the resonant and an off-resonant couplings of the plasma field to the atoms. In the case of the resonant coupling, the plasma field does not appear as a dissipative reservoir to the atoms. We adopt the image method and show that the dynamics of the two atoms are completely equivalent to those of a four-atom system. Moreover, two threshold coupling strengths exist, one corresponding to the strength of coupling of the plasma field to the symmetric and the other to the antisymmetric modes of the system. The thresholds distinguish between the non-Markovian and Markovian regimes of the evolutions. The solutions predict a large and long living entanglement mediated by the plasma field in both Markovian and non-Markovian regimes of the evolution. We also show that a simultaneous Markovian and non-Markovian regimes of the evolution may occur in which the memory effects exist over a finite evolution time. Keywords: met

Einstein-Podolsky-Rosen (EPR) steering is a quantum nonlocal effect which is intrinsically distinct from Bell nonlocality and quantum entanglement. In this paper, we investigate in detail the properties of steady-state light-mechanical Gaussian steerable correlations in a generic cavity optomechanical system. When considering the steering between the intracavity field and the mechanical oscillator, we find that under blue-detuned driving, the steady-state steering via optomechanical parametric downconversion is present in only one direction and, moreover, the steering direction is determined merely by the relative dissipation strength of the cavity to the mechanics. Furthermore, when considering the steering between the cavity output field and the mechanical oscillator, we reveal that under red-detuned driving, strong steering can be achieved in the sideband-unresolved regime for a filtered output field with given central frequency and bandwidth. This steering with the output field can also be present in one way by adjusting the driving strength and exists up to the environment temperature $T\ensuremath{\approx}10$ K for the parameters close to those in the recent experiments. Finally, we show that the achieved strong light-mechanical correlations can be explored to realize macroscopic EPR steering of two distant optomechanical oscillators in the regime of unresolved sidebands via entanglement swapping.