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315 results on '"Garancini, Mattia"'

1. Minimally invasive versus open liver resection for nonmetastatic hepatocellular carcinoma staged BCLC – B and – C: an Italian multicentric analysis

Author

Montalti, Roberto, Romano, Pierluigi, Carlis, Riccardo D., Ravaioli, Matteo, Ratti, Francesca, Razionale, Francesco, Oddi, Andrea, Marinelli, Laura, Cicerone, Ottavia, Russolillo, Nadia, Larghi Laureiro, Zoe, Marchitelli, Ivan, Malagnino, Alessia, Giuffrida, Mario, Alessandro Scotti, Mauro, Ciulli, Cristina, Ferraro, Valentina, Cucchetti, Alessandro, Casella, Annachiara, Cosola, Davide, Donadon, Matteo, Pelizzo, Patrizia, Manzoni, Alberto, Mantovani, Guido, Cammarata, Francesco, Patrone, Renato, Cassese, Gianluca, C. Giglio, Mariano, Vitale, Alessandro, Lauterio, Andrea, Serenari, Matteo, Cipriani, Federica, Ardito, Francesco, Perri, Pasquale, Nicolini, Daniele, Di Gioia, Giulio, Fontana, Andrea Pierluigi, Lai, Quirino, Conci, Simone, Fumagalli, Luca, Iaria, Maurizio, Garancini, Mattia, Molfino, Sarah, Zanello, Matteo, La Barba, Giuliano, Conticchio, Maria, Germani, Paola, Famularo, Simone, Romano, Maurizio, Zimmitti, Giuseppe, De Angelis, Michela, Troci, Albert, Belli, Andrea, Izzo, Francesco, Crespi, Michele, Boccia, Luigi, Abu Hilal, Mohamed, Zanus, Giacomo, Torzilli, Guido, Tarchi, Paola, Memeo, Riccardo, Ercolani, Giorgio, Jovine, Elio, Baiocchi, Gianluca, Romano, Fabrizio, Della Valle, Raffaele, Chiarelli, Marco, Ruzzenente, Andrea, Rossi, Massimo, Ferrero, Alessandro, Maestri, Marcello, Vivarelli, Marco, Grazi, Gian Luca, Giuliante, Felice, Aldrighetti, Luca, Cescon, Matteo, De Carlis, Luciano, Cillo, Umberto, and I. Troisi, Roberto

Published
2025
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2. IRON: A retrospective international multicenter study on robotic versus laparoscopic versus open approach in gallbladder cancer

Author

Ielpo, Benedetto, Vittoria d’Addetta, Maria, Burdio, Fernando, Sanchez-Velazquez, Patricia, Vellalta, Gemma, Cremona, Simone, Villamonte, Maria, Morelli, Luca, Furbetta, Niccoló, Di Franco, Gregorio, Comandatore, Annalisa, Mastrangelo, Mattia, Mazzone, Chiara, Masetti, Michele, Offi, Maria Fortuna, Geraldi, Eleonora, Aldrighetti, Luca, Ingallinella, Sara, Ratti, Francesca, Rosso, Edoardo, De Blasi, Vito, Anselmo, Alessandro, Conte, Luigi Eduardo, Memeo, Riccardo, Delvecchio, Antonella, Sukandy, Iswanto, Moraldi, Luca, Grazi, Gian Luca, Spampinato, Marcello G., D'Ugo, Stefano, Heng Chiow, Adrian Kah, Yi Yee, Francis Zheng, Tan, Hiang Jin, Thiruchelvam, Nita, Lancellotti, Francesco, Satyadas, Thomas, Fedi, Massimo, De Vincenti, Rosita, Leo, Francesca, Pesi, Benedetta, Belli, Andrea, Izzo, Francesco, Cutolo, Carmen, Romano, Fabrizio, Scotti, Mauro Alessandro, Carissimi, Francesca, Garancini, Mattia, Ciulli, Cristina, Mazzola, Michele, Ferrari, Giovanni, Zironda, Andrea, Giani, Alessandro, Giuliani, Giuseppe, Federica Dorma, Maria Pia, Guerra, Francesco, Di Marino, Michele, Coratti, Andrea, Mina, Elisa, Romanzi, Andrea, Prieto, Mikel, Perfecto, Arkaitz, Ioannidis, Orestis, Lombardeas, Odysseas, Ardito, Francesco, Giuliante, Felice, Lopez-Lopez, Victor, Robles-Campos, Ricardo, Martinie, John, Mccarron, Frances, Romito, Raffaele, Nicolosi, Filadelfio Massimiliano, Ben Dhaou, Anis, Chamekh, Atef, Rezgui, Bochra, Pacilli, Mario, Pavone, Giovanna, Tartaglia, Nicola, Gupta, Rahul, Grego, Davide Giovanni, Ricci, Claudio, Pata, Francesco, Nardo, Bruno, Facundo, Helena, Guevara, Oscar, Lorenzin, Dario, Guglielmi, Alfredo, Ruzzenente, Andrea, Valle, Valentina, Alberto, Mangano, Giulianotti, PierCristoforo, Vicente, Emilio, Ferri, Valentina, Avella, Pasquale, Calise, Fulvio, Rocca, Aldo, Bianchi, Paolo, Rompianesi, Gianluca, Troisi, Roberto I., Donadon, Matteo, di Martino, Marcello, Podda, Mauro, Pisanu, Adolfo, Torzilli, Guido, Vittoria d'Addetta, Maria, Di Martino, Marcello, and Giulianotti, Pier Cristoforo

Published
2024
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5. Laparoscopic versus open resection for hepatocellular carcinoma according to the procedure’s complexity: real-world weighted data from a national register

Author

Corleone, PioS., Ciulli, Cristina, Bernasconi, Davide, Donadon, Matteo, Procopio, Fabio, Razionale, Francesco, Ratti, Francesca, Romano, Pierluigi, De Carlis, Riccardo, Russolillo, Nadia, Marinelli, Laura, Iaria, Maurizio, De Stefano, Francesca, Scarinci, Andrea, Laureiro, Zoe L., Scotti, Mauro, Marchitelli, Ivan, Rompianesi, Gianluca, Cucchetti, Alessandro, Franceschi, Angelo, Casella, Annachiara, Cosola, Davide, Patrizia, Pelizzo, Notte, Francesca, Patrone, Renato, Manzoni, Alberto, Sciannamea, Ivano, Malagnino, Alessia, Cammarata, Francesco, Mantovani, Guido, Famularo, Simone, Milana, Flavio, Ardito, Francesco, Cipriani, Federica, Vitale, Alessandro, Lauterio, Andrea, Serenari, Matteo, Fontana, Andrea, Nicolini, Daniele, Giuffrida, Mario, Garancini, Mattia, Dominioni, Tommaso, Zanello, Matteo, Perri, Pasquale, Lai, Quirino, Conci, Simone, Molfino, Sarah, Giglio, Mariano, LaBarba, Giuliano, Ferrari, Cecilia, Conticchio, Maria, Germani, Paola, Romano, Maurizio, Patauner, Stefan, Belli, Andrea, Zimmitti, Giuseppe, Antonucci, Adelmo, Fumagalli, Luca, Troci, Albert, De Angelis, Michela, Boccia, Luigi, Crespi, Michele, Hilal, Moh’d A., Izzo, Francesco, Frena, Antonio, Zanus, Giacomo, Tarchi, Paola, Memeo, Riccardo, Griseri, Guido, Ercolani, Giorgio, Troisi, Roberto, Baiocchi, Gian L., Ruzzenente, Andrea, Rossi, Massimo, Grazi, Gian L., Jovine, Elio, Maestri, Marcello, Romano, Fabrizio, Valle, Raffaele D., Vivarelli, Marco, Ferrero, Alessandro, Cescon, Matteo, De Carlis, Luciano, Cillo, Umberto, Aldrighetti, Luca, Giuliante, Felice, and Torzilli, Guido

Published
2024
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6. Dynamic surgical anatomy using 3D reconstruction technology in complex hepato-biliary surgery with vascular involvement. Results from an international multicentric survey

Author

Cotsoglou, Christian, Granieri, Stefano, Bassetto, Serena, Bagnardi, Vincenzo, Pugliese, Raffaele, Grazi, Gian Luca, Guglielmi, Alfredo, Ruzzenente, Andrea, Aldrighetti, Luca, Ratti, Francesca, De Carlis, Luciano, De Carlis, Riccardo, Centonze, Leonardo, De Angelis, Nicola, Memeo, Riccardo, Delvecchio, Antonella, Felli, Emanuele, Izzo, Francesco, Belli, Andrea, Patrone, Renato, Ettorre, Giuseppe Maria, Berardi, Giammauro, Di Benedetto, Fabrizio, Di Sandro, Stefano, Romano, Fabrizio, Garancini, Mattia, Scotti, Mauro Alessandro, Bianchi, Giorgio, Germini, Alessandro, Gjoni, Elson, Bonomi, Alessandro, Bruno, Federica, Paleino, Sissi, and Pugliese, Giacomo

Published
2024
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7. Survival benefit of second line therapies for recurrent hepatocellular carcinoma: repeated hepatectomy, thermoablation and second-line transplant referral in a real life national scenario

Author

Milana, Flavio, Bertacco, Alessandra, De Carlis, Riccardo, Ratti, Francesca, Russolillo, Nadia, Iaria, Maurizio, Razionale, Francesco, Tartaglia, Giuseppe, Ciulli, Cristina, Carissimi, Francesca, Laureiro, Zoe L., Marinelli, Laura, DePeppo, Valerio, Montuori, Mauro, Marchitelli, Ivan, Franceschi, Angelo, Notte, Francesca, Manzoni, Alberto, Cosola, Davide, Corleone, Pio, Fumagalli, Luca, Salvador, Luca, Mantovani, Guido, Cucchetti, Alessandro, Cammarata, Francesco, Conticchio, Maria, Patrone, Renato, Bernasconi, Davide P., Famularo, Simone, Cillo, Umberto, Lauterio, Andrea, Donadon, Matteo, Vitale, Alessandro, Serenari, Matteo, Cipriani, Federica, Fazio, Federico, Giuffrida, Mario, Ardito, Francesco, Dominioni, Tommaso, Garancini, Mattia, Lai, Quirino, Nicolini, Daniele, Molfino, Sarah, Perri, Pasquale, Pinotti, Enrico, Conci, Simone, Ferrari, Cecilia, Zanello, Matteo, Patauner, Stefan, Zimmitti, Giuseppe, Germani, Paola, Chiarelli, Marco, Romano, Maurizio, De Angelis, Michela, La Barba, Giuliano, Troci, Albert, Ferraro, Valentina, Izzo, Francesco, Antonucci, Adelmo, Belli, Andrea, Memeo, Riccardo, Crespi, Michele, Ercolani, Giorgio, Boccia, Luigi, Zanus, Giacomo, Tarchi, Paola, Hilal, Moh'd Abu, Frena, Antonio, Jovine, Elio, Griseri, Guido, Ruzzenente, Andrea, Zago, Mauro, Grazi, Gianluca, Baiocchi, Gian L., Vivarelli, Marco, Rossi, Massimo, Romano, Fabrizio, Maestri, Marcello, Giuliante, Felice, Valle, Raffaele D., Ferrero, Alessandro, Aldrighetti, Luca, De Carlis, Luciano, Cescon, Matteo, and Torzilli, Guido

Published
2023
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9. The largest western experience on salvage hepatectomy for recurrent hepatocellular carcinoma: propensity score-matched analysis on behalf of He.RC.O.Le.Study Group

Author

Giuffrida, Mario, Russolillo, Nadia, Razionale, Francesco, De Peppo, Valerio, Tomasoni, Matteo, Marchitelli, Ivan, Costa, Guido, Laureiro, Zoe L., Scotti, Mauro, Calcagno, Pietro, Cosola, Davide, Franceschi, Angelo, Manzoni, Alberto, Pennacchi, Luca, Montuori, Mauro, Conticchio, Maria, Ratti, Francesca, Notte, Francesca, Cucchetti, Alessandro, Salvador, Luca, Corleone, Pio, Garancini, Mattia, Ciulli, Cristina, Iaria, Maurizio, Bianchi, Giorgio, Fazio, Federico, Ardito, Francesco, Perri, Pasquale, Pontarolo, Nicholas, Conci, Simone, Donadon, Matteo, Zanello, Matteo, Lai, Quirino, Famularo, Simone, Molfino, Sarah, Sciannamea, Ivano, Fumagalli, Luca, Germani, Paola, Floridi, Antonio, Ferrari, Cecilia, Zimmitti, Giuseppe, Troci, Albert, Zago, Mauro, Ferraro, Valentina, Cipriani, Federica, Patauner, Stefan, La Barba, Giuliano, Romano, Maurizio, Zanus, Giacomo, Ercolani, Giorgio, Frena, Antonio, Aldrighetti, Luca, Memeo, Riccardo, Pinotti, Enrico, Crespi, Michele, Hilal, Moh'd Abu, Griseri, Guido, Tarchi, Paola, Chiarelli, Marco, Antonucci, Adelmo, Baiocchi, Gian L., Romano, Fabrizio, Rossi, Massimo, Jovine, Elio, Torzilli, Guido, Ruzzenente, Andrea, Maestri, Marcello, Grazi, Gian L., Giuliante, Felice, Ferrero, Alessandro, and Dalla Valle, Raffaele

Published
2022
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10. Spatially Resolved Molecular Characterization of Noninvasive Follicular Thyroid Neoplasms with Papillary-like Nuclear Features (NIFTPs) Identifies a Distinct Proteomic Signature Associated with RAS-Mutant Lesions.

Author

Denti, Vanna, Greco, Angela, Alviano, Antonio Maria, Capitoli, Giulia, Monza, Nicole, Smith, Andrew, Pilla, Daniela, Maggioni, Alice, Ivanova, Mariia, Venetis, Konstantinos, Maffini, Fausto, Garancini, Mattia, Pincelli, Angela Ida, Galimberti, Stefania, Magni, Fulvio, Fusco, Nicola, L'Imperio, Vincenzo, and Pagni, Fabio

Subjects
PROTEIN kinases, MICROSCOPY, NUCLEOTIDE sequencing, MASS spectrometry, PROTEOMICS, MATRIX-assisted laser desorption-ionization
Abstract

Follicular-patterned thyroid neoplasms comprise a diverse group of lesions that pose significant challenges in terms of differential diagnosis based solely on morphologic and genetic features. Thus, the identification of easily testable biomarkers complementing microscopic and genetic analyses is a highly anticipated advancement that could improve diagnostic accuracy, particularly for noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTPs). These tumors exhibit considerable morphological and molecular heterogeneity, which may complicate their distinction from structurally similar neoplasms, especially when genetic analyses reveal shared genomic alterations (e.g., RAS mutations). Here, we integrated next-generation sequencing (NGS) with matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) to perform a proteogenomic analysis on 85 NIFTPs (n = 30 RAS-mutant [RAS-mut] and n = 55 RAS-wild type [RAS-wt]), with the aim to detect putative biomarkers of RAS-mut lesions. Through this combined approach, we identified four proteins that were significantly underexpressed in RAS-mut as compared to RAS-wt NIFTPs. These proteins could serve as readily accessible markers in morphologically borderline cases showing RAS mutations. Additionally, our findings may provide insights into the distinct pathogenic pathways through which RAS-mut and RAS-wt NIFTPs arise, highlighting the pivotal role of constitutive RAS–mitogen-activated protein kinase (MAPK) pathway activation in the development and progression of RAS-mut tumors. [ABSTRACT FROM AUTHOR]

Published
2024
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12. The Effect of a Liver Transplant Program on the Outcomes of Resectable Hepatocellular Carcinoma: A Nationwide Multicenter Analysis

Author

Serenari, Matteo, Lenzi, Jacopo, Cucchetti, Alessandro, Cipriani, Federica, Donadon, Matteo, Ardito, Francesco, Fazio, Federico, Nicolini, Daniele, Iaria, Maurizio, Famularo, Simone, Perri, Pasquale, Ansaloni, Luca, Zanello, Matteo, Lai, Quirino, Conci, Simone, Molfino, Sarah, Ferrari, Cecilia, Germani, Paola, Zago, Mauro, Romano, Maurizio, Zimmitti, Giuseppe, Antonucci, Adelmo, Fumagalli, Luca, Troci, Albert, Ferraro, Valentina, Memeo, Riccardo, Crespi, Michele, Chiarelli, Marco, Ercolani, Giorgio, Hilal, Mohamed A., Zanus, Giacomo, Pinotti, Enrico, Tarchi, Paola, Griseri, Guido, Baiocchi, Gian Luca, Ruzzenente, Andrea, Rossi, Massimo, Jovine, Elio, Maestri, Marcello, Grazi, Gian Luca, Romano, Fabrizio, Dalla Valle, Raffaele, Ravaioli, Matteo, Vivarelli, Marco, Ferrero, Alessandro, Giuliante, Felice, Torzilli, Guido, Aldrighetti, Luca, Cescon, Matteo, Gorgone, Mara, Ratti, Francesca, Costa, Guido, Razionale, Francesco, Russolillo, Nadia, Marinelli, Laura, Giuffrida, Mario, Scotti, Mauro, Garancini, Mattia, De Peppo, Valerio, De Stefano, Francesca, Laureiro, Zoe Larghi, Marchitelli, Ivan, Franceschi, Angelo, Cosola, Davide, Corleone, Pio, Montuori, Mauro, Salvador, Luca, Manzoni, Alberto, La Barba, Giuliano, Calcagno, Pietro, Pennacchi, Luca, and Conticchio, Maria

Published
2023
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13. Lobar and Segmental Atrophy of the Liver: Differential Diagnoses and Treatments.

Author

Ferraina, Federica, Fogliati, Alessandro, Scotti, Mauro Alessandro, Romano, Fabrizio, Garancini, Mattia, and Ciulli, Cristina

Subjects
LIVER disease diagnosis, LIVER disease treatment, LIVER tumors, PORTAL vein, DIFFERENTIAL diagnosis, ATROPHY, LIVER diseases, CHOLESTASIS, GALLSTONES, HEPATOCELLULAR carcinoma, BILE ducts
Abstract

Segmental or lobar liver atrophy is a common but not well-understood clinical condition. Hepatic atrophy can be classified into hepatic atrophy secondary to other pathologies and primary segmental hepatic atrophy, which is a benign intrahepatic lesion (pseudotumor) not associated with any other pathology. The pathophysiological mechanisms underlying atrophy can be divided into three main situations: obstruction of biliary outflow, obstruction of the systemic venous outflow, and obstruction of incoming portal venous flow. For what may concern secondary hepatic atrophy, there are many pathologies that could underlie this condition, ranging from benign to intrahepatic malignancies, with particular reference to particularly hepatocellular carcinoma and biliary duct carcinoma. An accurate and prompt differential diagnosis between the various forms and causes of atrophy is important for early identification and adequate treatment of underlying pathologies. A comprehensive review of the literature on the etiology and the radiological and histological characteristics of different types of hepatic atrophy is currently unavailable. Therefore, the aim of this review is to summarize the primary and secondary causes of segmental or lobar liver atrophy (excluding forms involving the entire liver parenchyma) and to provide practical tools for clinical and radiological differential diagnosis. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Understanding Factors Associated With Psychomotor Subtypes of Delirium in Older Inpatients With Dementia

Author

Rispoli, Vincenzo, Malara, Alba, Spadea, Fausto, Di Cello, Serena, Ceravolo, Francesco, Fabiano, Francesco, Chiaradia, Giuseppe, Gabriele, Amedeo, Lenino, Peluso, Andrea, Taristano, Settembrini, Vincenzo, Capomolla, Domenico, Citrino, Antonella, Scriva, Antonietta, Bruno, Irene, Secchi, Roberto, De Martino, Eugenio, Muccinelli, Roberto, Lupi, Gerardo, Paonessa, Patrizio, Fabbri, Andrea, Passuti, Maria Teresa, Castellari, Sofia, Po, Andrea, Gaggioli, Guido, Varesi, Massimo, Moneti, Paolo, Capurso, Sebastiano, Latini, Vincenzo, Ghidotti, Stefano, Riccardelli, Francesco, Macchi, Maurizio, Rigo, Rosaria, Claudio, Pascale, Angelo, Bosio, Flavio, Cerrato, Benedetta, Bardelli, Boffelli, Stefano, Cassinadri, Angela, Franzoni, Simone, Spazzini, Elena, Andretto, Daniela, Tonini, Gabriele, Andreani, Laura, Coralli, Mirco, Balotta, Antonio, Cancelliere, Roberto, Ballardini, Giorgio, Simoncelli, Margherita, Mancini, Annarita, Strazzacapa, Mara, Fabio, Stefano, De Filippi, Francesco, Giudice, Chiara, Dentizzi, Cosimo, Azzini, Margherita, Cazzadori, Marco, Mastroeni, Valeria, Bertassello, Paolo, Claudia Benati, Helena Santana, Nesta, Elisa, Tobaldini, Chiara, Guerini, Fabio, Elena, Tambara, Mombelloni, Paolo, Fontanini, Fulvio, Gabriella, Lassa, Pizzorni, Crosio, Oliverio, Martina, Del Grosso, Luciano Luca, Giavedoni, Cristina, Bidoli, Giuliano, Mazzei, Bruno, Corsonello, Andrea, Fusco, Sergio, Vena, Silvio, De Vuono, Tommaso, Maiuri, Giorgio, Luca, Fimognari Filippo, Andrea, Arone, Giovanni, Sgrò, Rossella, Nicolazzo, Castegnaro, Eugenio, De Rosa, Salvatore, Sechi, Rossella Bazzano, Benvenuti, Enrico, Del Lungo, Ilaria, Giardini, Sante, Giulietti, Chiara, Mauro, Di Bari, Eleonora, Barghini, Martina, Paoli, Irene, Fiordelli, Riccardo, Barucci, Federica, Sgrilli, Ilaria, Del Lungo, Bertoletti, Erik, D'Amico, Ferdinando, Caronzolo, Francesco, Grippa, Alessandro, Lombardo, Giuseppina, Pipicella, Tiziana, Antonino, Saitta, Francesco, Corica, Valeria, Prestipino Giarritta, Daniela, Larosa, Domenico, Cucinotta, Giorgio, Basile, March, Albert, Nitti, Maria Teresa, Felici, Alessandro, Pavan, Silvia, Piazzani, Fabrizio, Lunelli, Alessandra, Dimori, Sergio, Margotta, Alessandro, Soglia, Tiziano, Postacchini, Demetrio, Brunelli, Roberto, Santini, Silvia, Francavilla, Monia, Macchiati, Ilenia, Sorvillo, Francesca, Giuli, Cinzia, Mecocci, Patrizia, Longo, Annalisa, Perticone, Francesco, Addesi, Desireè, Rosa, Paola Cerra, Bencardino, Giuseppe, Falbo, Tania, Grillo, Nadia, Marco, Filice, Mirella, Flippo, Fantò, Fausto, Isaia, Gianluca, Pezzilli, Stella, Bergamo, Daniele, Furno, Elisabetta, Rrodhe, Sokol, Lucarini, Simonetta, Dijk, Babette, Dall'Acqua, Francesca, Cappelletto, Francesco, Calvani, Donatella, Becheri, Dimitri, Giuseppe, Mottino, Costanza, Mitidieri, Vito, Antonio, Francesca, Bartalucci, Magherini, Lorenza, Novella, Malin, Franca, Boni, Lucia Gambardella, Paoli Martina, Valente, Carlo, Ilaria, Bracali, Alice, Foschini, Bo, Mario, Porrino, Paola, Ceci, Giacomo, Giuliana, Bottignole, Michela, Tibaldi, Eleonora, Coppo, Ettore, Evaristo, Camellini, Cinzia, Servello, Adriana, Grassi, Alessandro, Rozzini, Renzo, Tironi, Sara, Grassi, Maria Grazia, Troisi, Elio, Carlo, Caltagirone, Simona Gabriella, Di Santo, Flaminia, Franchini, Federica, Ratto, Beatrice, Pavoni, Sofia, Toniolo, Gabutto, Anna, Quazzo, Loredana, Rosatello, Annalisa, Suraci, Domenico, Tagliabue, Benedetta, Perrone, Chiara, Ferrara, Lucia, Castagna, Alberto, Tremolada, Maria Luisa, Giuseppe, Castoldi, Stefano, Barbero, Davide, Oltramonti, Piano, Simonetta, Serviddio, Gaetano, Lo Buglio, Aurelio, Gurrera, Tiziana, Merlo, Valeria, Rovai, Carla, Cotroneo, Antonino Maria, Carlucci, Rosaria, Abbaldo, Anna, Monzani, Fabio, Qasem, Ahmad Amedeo, Bini, Giacomo, Tafuto, Silvia, Galli, Giovanni, Bruni, Amalia Cecilia, Mancuso, Giovanna, Mancuso, Gerardo, Calipari, Daniela, Giuseppe Massimiliano, De Luca, Bernardini, Bruno, Corsini, Carla, Michele, Ciccarelli, Sara, Dal Farra, Cagnin, Annachiara, Fragiacomo, Federica, Pompanin, Sara, Piero, Amodio, Marco, Cagnin, Zurlo, Amedeo, Guerra, Gianluca, Pala, Marco, Menozzi, Luca, Gatti, Chiara Delli, Magon, Stefania, Roberto, Manfredini, Alfredo, De Giorgi, Fabio, Fabbian, Ruana, Tiseo, Elisa, Misurati, Benedetta, Boari, Christian, Molino, Marco, Pala, Massimo, Gallerani, Di Francesco, Vincenzo, Faccioli, Silvia, Pellizzari, Luca, Giorgia, Fontana, Barbagallo, Giuseppe, Lunardelli, Maria Lia, Martini, Emilio, Ferrari, Eleonora, Macchiarulo, Maria, Corneli, Maria, Bacci, Monica, Battaglia, Giuseppe, Anastasio, Luigi, Lo Storto, Mario Sostene, Seresin, Chiara, Simonato, Matteo, Loreggian, Michele, Cestonaro, Fausta, Durando, Mario, Latella, Raffaele, Mazzoleni, Marta, Russo, Giuseppe, Ponte, Martino, Valchera, Alessandro, Salustri, Giuseppe, Petritola, Donatella, Costa, Alfredo, Sinforiani, Elena, Cotta, Matteo Ramusino, Pizio, Renato Nicola, Cester, Alberto, Formilan, Marino, Pietro, Bonometto, Carbone, Pasqualina, Cazzaniga, Ilaria, Appollonio, Ildebrando, Cereda, Diletta, Stabile, Andrea, Xhani, Rubjona, Acampora, Roberto, Tremolizzo, Lucio, Federico, Pieruzzi, Antonio, Ciaccio, Valerio, Pontecorvi, Cesare, Burti, Zhirajr, Mokini, Giovanni, Vitale, Maria, Amigoni, Mariaelena, Sparacino, Bottacchi, Edo, Bucciantini, Elisabetta, Di Giovanni, Marco, Franchi, Fabrizio, Lucchetti, Lucio, Mariani, Claudio, Grande, Giulia, Rapazzini, Piero, Marco, Mauri, Romanelli, Giuseppe, Marengoni, Alessandra, Franco, Nicosia, Alessio, Margola, Stefano, Bonardelli, Nicola, Latronico, Laura, Porcella, Nazario, Portolani, Carlo, Concoreggi, Chiara, Grassini, Soccorso, Pronto, Andrea, Salvi, Luca, Bianchetti, Francesca, Spagnoli, Roberto, Apuzzo, Marco, Fontanella, Anna, Ceraso, Francesco, Castelli, Fugazza, Luciano, Guerrini, Chiara, De Paduanis, Giovanna, Iallonardo, Lucia, Palumbo, Pasquale, Zuliani, Giovanni, Ortolani, Beatrice, Capatti, Eleonora, Soavi, Cecilia, Bianchi, Lara, Francesconi, Daniela, Miselli, Agata, Gloria, Brombo, Tommaso, Romagnoli, Chiara, Pazzaglini, Agata, Miselli Maria, Marco, Dall'Agata, Luca, Menozzi, Gianluca, Guerra, Suardi, Teresa, Mazzone, Andrea, Zaccarini, Cinzia, Manuela, Riva, Mirra, Gianluca, Muti, Ettore, Bottura, Renato, Gianpaolo, Moretti, Secreto, Piero, Bisio, Erika, Cecchettani, Marco, Naldi, Tamara, Pallavicino, Alessandra, Pugliese, Michela, Iozzo, Rosaria Cosima, Grassi, Guido, Michele, Bombelli, Raffaella, Dell'Oro, Fosca, Quarti Trevano, Giorgio, Giussani Carlo, Giovanni, Paternò, Ernesto, Contro, Mannironi, Antonio, Giorli, Elisa, Oberti, Sara, Fierro, Brigida, Piccoli, Tommaso, Giacalone, Fabio, Mandas, Antonella, Serchisu, Luca, Costaggiu, Diego, Pinna, Elisa, Orrù, Francesca, Mannai, Martina, Cordioli, Zeno, Pelizzari, Luca, Turcato, Emanuela, Arduini, Pietro, Cacace, Carlo, Chiloiro, Roberta, Cimino, Rosella, Ruberto, Carmen, Giovanni, Ruotolo, Pietro, Gareri, Laura, Greco, Alberto, Castagna, Carmen, Ruberto, Santo, Pierluigi Dal, Andriolli, Antonino, Burattin, Giuseppe, Rossi, Laura, Andreolli Antonino, Cervati Giovanna, Giuseppe, Catalano, Tezza, Fabiana, Maddalena, Pizzardini, Laura, Stievano, Crippa, Patrizia, Aloisio, Paola, Di Monda, Tiziana, Malighetti, Alessandro, Galbassini, Gloria, Salutis, Domus, Ivaldi, Claudio, Russo, Anna Maria, Bennati, Ettore, Pino, Elisabetta, Zavarise, Gianmaria, Pesci, Alberto, Suigo, Giulia, Faverio, Paola, Andrea, Gori, Sabrina, Perego, Zanasi, Massimo, Moniello, Giovanni, Rostagno, Carlo, Cartei, Alessandro, Polidori, Gianluca, Ungar, Andrea, Melis, Maria Ramona, Martellini, Eleonora, Enrico, Mossello, Monica, Torrini, Antonella, Giordano, Giovanna, Leone, Migliorini, Marta, Caramelli, Francesca, Battiston, Bruno, Berardino, Maurizio, Cavallo, Simona, Alessandro, Massè, Anna, Santoro, Lombardi, Bruna, D'Ippolito, Pierpaolo, Furini, Angela, Villani, Daniele, Clara, Raimondi, Guarneri, Massimo, Paolucci, Stefano, Bassi, Andrea, Coiro, Paola, De Angelis, Domenico, Morone, Giovanni, Venturiero, Vincenzo, Palleschi, Lorenzo, Raganato, Paolo, Di Niro, Giuseppina, Rosa, Casini Anna, Loredana, Bove, Imoscopi, Alessandra, Isaia, Giancarlo, Tibaldi, V., Bottignole G, G., Calvi, E., Clementi, C., Zanocchi, M., Agosta, L., Nortarelli, Antonella, Provenzano, Giuseppe, Mari, Daniela, Romano, Federica Ylenia, Rosini, Francesca, Mansi, Marta, Rossi, Silvia, Geriatria, Alex Riccardelli, Inzaghi, Lorenzo, Bonini, Giulia, Rossi, Paolo, Potena, Alfredo, Lichii, Mihaela, Candiani, Tiziana, Grimaldi, William, Bertani, Emiliano, Alessandra, Porta, Calogero, Pietro, Pinto, Daniela, Bernardi, Roberto, Nicolino, Francesco, Galetti, Caterina, Gianstefani, Alice, Giulia, Corvalli, Lorenzo, Mulazzani, Odetti, Patrizio, Monacelli, Fiammetta, Prefumo, Matteo, Fiammetta, Monacelli, Canepa, Marta, Minaglia, Cecilia, Paolisso, Giuseppe, Rizzo, Maria Rosaria, Prestano, Raffaele, Dalise, Anna Maria, Barra, Davide, Bosco, Livio Dal, Asprinio, Vincenzo, Dallape, Luciana, Perina, Elisa, Incalzi, Raffaele Antonelli, Bartoli, Isaura Rossi, Pluderi, Alice, Maina, Antonella, Pecoraro, Elisabetta, Sciarra, Michela, Prudente, Angela, Paola, Maina, Francesca, Mete, Manuel, Ventura, Luisella, Cesari, Maria, Pernigotti Luigi, Tina, Santangelo, Benini, Lucia, Levato, Francesco, Mhiuta, Victor, Alius, Florin, Davidoaia, Diana, Giardini, Vittorio, Garancini, Mattia, Bellamoli, Claudio, Terranova, Luciano, Bozzini, Claudia, Tosoni, Paolo, Provoli, Emma, Cascone, Luisa, Dioli, Andrea, Ferrarin, Gianfranco, Bucci, Adelmo, Bua, Guido, Fenu, Sara, Bianchi, Giovanna, Casella, Silvia, Romano, Valentina, Maurizio, Poli, Mascherona, Ilenia, Belotti, Gloria, Cavaliere, Sabina, Cuni, Estella, Merciuc, Nina, Oberti, Rosella, Veneziani, Silvia, Capoferri, Emanuela, De Bernardi, Elisabetta, Colombo, Katia, Bravi, Marco, Nicoletta, Negrinotti, D'Arcangelo, Paolo, Montenegro, Nicola, Montanari, Roberto, Lamanna, Pierpaolo, Gasperini, Beatrice, Isabella, Montesi, Stefania, Diotallevi, Gaia, Altobelli, Filippo, Calcinaro, Palamà, Chiara, Di Emidio, Chiara, Scarpini, Elio, Arighi, Andrea, Fumagalli, Giorgio, Basilico, Paola, De Amicis Margherita, Migone, Marta, Mancarella, Diletta, Maira, Granata, Antonino, Ranalli, Claudia, Cammilli, Alessandra, Cavallini, Maria Chiara, Tricca, Manola, Natella, Daniela, Gabbani, Luciano, Tesi, Francesca, Martella, Letizia, Imbrici, Rosalba, Guerrini, Gianbattista, Scotuzzi, Anna Maria, Sozzi, Ferdinando, Valenti, Luigi, Chiarello, Antonino, Monia, Monella, Pilotto, Alberto, Prete, Camilla, Senesi, Barbara, Meta, Anna Cristina, Pendenza, Enrico, Pasqualetti, Giuseppe, Polini, Antonio, Tognini, Sara, Ballino, Elena, Cherubini, Antonio, Dell'Aquila, Giuseppina, Gasparrini, Pina Maria, Marotti, Elisabetta, Migale, Monica, Scrimieri, Antonia, Falsetti, Lorenzo, Salvi, Aldo, Toigo, Gabriele, Ceschia, Giuliano, Rosso, Alessia, Tongiorgi, Chiara, Scarpa, Cristina, Maurizio, Pacchioni, De Dominicis, Luigino, Pucci, Eugenio, Renzi, Sara, Cartechini, Elisabetta, Tomassini, Pia Francesca, Del Gobbo, Maurizio, Ugenti, Francesca, Romeo, Pasquale, Nardelli, Anna, Lauretani, Fulvio, Visioli, Sandra, Montanari, Ilaria, Ermini, Francesca, Giordano, Antonio, Pigato, Giorgio, Simeone, Emilio, Barbujani, Mario, Giampieri, Marina, Amoruso, Raffaele, Piccinini, Maristella, Ferrari, Camilla, Gambetti, Claudio, Sfrappini, Mario, Semeraro, Letizia, Striuli, Rinaldo, Mariani, Claudia, Pelliccioni, Giuseppe, Marinelli, Donatella, Fabi, Katia, Rossi, Tommaso, Pesallaccia, Martina, Sabbatini, Debora, Gobbi, Beatrice, Cerqua, Raffaella, Tagliani, Giancarla, Schlauser, Elena, Caser, Luciano, Caramello, Elisa, Sandigliano, Franca, Rosso, Giorgio, Ferrari, Alberto, Bendini, Chiara, Luisa, Davoli Maria, Casella, Monica, Prampolini, Raffaella, Scevola, Moreno, Vitale, Enrico, Roberto, Brugiolo, Carlo, Fagherazzi, Sergio, Fusco, Alberto, Scarpa, Daniela, Zara, Giulia, Bertozzo, Serena, Granziera, Michele, Barazzuol, Maugeri, Domenico, Sorace, Rosaria, Anzaldi, Massimiliano, De Gesu, Roberto, Morrone, Giuseppe, Davolio, Federica, Fabbo, Andrea, Palmieri, Marina, Zoli, Marco, Forti, Paola, Pirazzoli, Luca, Fabbri, Elisa, Terenzi, Laura, Bergolari, Federica, Wenter, Christian, Ruffini, Ingrid, Insam, Miriam, Abraham, Elisabeth, Kirchlechner, Christine, Cucinotta, Domenico, Antonino, Lasco, Basile, Giorgio, Grazia, Arena Maria, Parise, Pasquale, Boccali, Andrea, Amici, Serena, Gambacorta, Maurizia, Lasagni, Anna, Lovati, Roberto, Giovinazzo, Francesca, Kimak, Elzbieta, Zappa, Paolo, Medici, Francesco, Lo Castro, Marika, Mauro, Flavia, De Luca, Alessandro, Sancesario, Giuseppe, Martorana, Alessandro, Scaricamazza, Beatrice, Toniolo, Sofia, Di Lorenzo, Francesco, Liguori, Claudio, Lasco, Antonino, Vita, Natale, Giomi, Mirna, Forte, Floriana, Padovani, Alessandro, Rozzini, Luca, Ceraso, Anna, Salvatore, Caratozzolo, Cottino, Maria, Vitali, Silvia, Marelli, Eleonora, Tripi, Gabriele, Miceli, Salvatore, Urso, Giovanni, Grioni, Giuseppe, Vezzadini, Giuliana, Misaggi, Giulia, Forlani, Chiara, Avanzi, Stefano, Serena, Saulle, Claudia, Casarini, Marilena, Viggiano, Alberto, Luisa, Diego, Ghianda, Alessandro, Giordano, Iemolo, Francesco, Giordano, Antonello, Sanzaro, Enzo, D'Asta, Gabriele, Proietto, Maria, Carnemolla, Anna, Razza, Grazia, Spadaro, Daniela, Bertolotti, Marco, Mussi, Chiara, Neviani, Francesca, Roberto, Chiesa, Valentina, Guerzoni, Linda, Morselli, Francesca, Venturelli, Tarozzi, Adriano, Balestri, Francesca, Mannarino, Giulio, Bigolari, Michela, Natale, Alessia, Grassi, Simona, Bottaro, Cinzia, Stefanelli, Sara, Bovone, Ugo, Tortorolo, Umberto, Quadri, Roberto, Leone, Giuseppe, Ponzetto, Maria, Frasson, Paola, Annoni, Giorgio, Bellelli, Giuseppe, Bruni, Adriana, Confalonieri, Roberto, Corsi, Maurizio, Moretti, Daniela, Teruzzi, Fabiola, Umidi, Simona, Mazzola, Paolo, Perego, Sabrina, Persico, Ilaria, Olivieri, Giulia, Bonfanti, Alessandra, Hajnalka, Szabò, Galeazzi, Marianna, Massariello, Francesca, Anzuini, Alessandra, Caffarra, Paolo, Barocco, Federica, Spallazzi, Marco, Paolo, Ceda Gian, Simonetta, Morganti, Andrea, Artoni, Chioatto, Paolo, Bortolamei, Sandra, Soattin, Lucia, Ruotolo, Giovanni, Beneamino, Borelli, Giuseppe, Barilaro, Bertazzoli, Marco, Rota, Elisabetta, Adobati, Annamaria, Scarpa, Alberto, Granziera, Serena, Zuccher, Paola, Fabbro, Angela Dal, Zara, Daniela, Lo Nigro, Ambra, Franchetti, Lorena, Toniolo, Marika, Marcuzzo, Cinzia, Rollone, Marco, Guerriero, Fabio, Sgarlata, Carmelo, Massè, Alessandro, Zatti, Giovanni, Piatti, Massimiliano, Graci, Jole, Benati, Giuseppe, Boschi, Federica, Biondi, Mario, Fiumi, Nicoletta, Erika, Tamburini, Locatelli, Sergio Mario, Mauri, Sabrina, Beretta, Mauro, Margheritis, Laura, Desideri, Giovanbattista, Liberatore, Ester, Carucci, Anna Cecilia, Bonino, Paolo, Caput, Margherita, Antonietti, Maria Paola, Polistena, Giuseppe, De la Pierre, Franz, Mari, Marcello, Massignani, Paola, Tombesi, Fabio, Selvaggio, Fabio, Verbo, Brunella, Bodoni, Paolo, Marchionni, Niccolò, Mossello, Enrico, Sabatini, Tony, Mussio, Eleonora, Magni, Eugenio, Bianchetti, Angelo, Crucitti, Andrea, Titoldini, Giulia, Cossu, Beatrice, Fascendini, Sara, Licini, Cristina, Tomasoni, Angela, Calderazzo, Massimo, Daniela, Tropiano, Valentina, Laganà, Melotti, Rita Maria, Lilli, Albina, Buda, Simona, Adversi, Marco, Noro, Gabriele, Turco, Renato, Ubezio, M Chiara, Mantovani, Anna Roberta, Viola, Maria Cristina, Serrati, Carlo, Pretta, Stefano, Infante, Maria, Gentile, Simona, Morandi, Alessandro, D'Ambrosio, Viviana, Mazzanti, Paolo, Brambilla, Cristina, Sportelli, Silvia, Platto, Caterina, Faraci, Bianca, Quattrocchi, Daniela, Pernigotti, Luigi Maria, Pisu, Cristina, Sicuro, Francesca, Zagnoni, Piergiuseppe, Ghiglia, Stefania, Mosca, Massimiliano, Corazzin, Ileana, Deola, Mariangela, Biagini, Carlo Adriano, Bencini, Francesca, Cantini, Claudia, Tonon, Elisabetta, Pierinelli, Silvia, Onofrj, Marco, Thomas, Astrid, Filomena, Borbone, Bonanni, Laura, Gabriella, Cacchiò, Comi, Giancarlo, Magnani, Giuseppe, Santangelo, Roberto, Mazzeo, Salvatore, Giuseppe, Magnani, Francesca, Caso, Giordano, Cecchetti, Roberto, Sant'Angelo, Barbieri, Cristina, Giroldi, Liviana, Bandini, Fabio, Masina, Marco, Malservisi, Simona, Cicognani, Annalena, Ricca, Laura, Piccininni, Maristella, Tassinari, Tiziana, Brogi, Davide, Sugo, Annalisa, Alessandra, Filippi, Sonia, Manfredi, Valerio, Vanni, Andrea, Usai Carlo, Enrico, Colombo, Vera, Renna Francesca, Assunta, Sauchella, Gianmaria, Zavarise, Mauro, Prete, Pietro, Bisagni, Roberto, Masini, Salvatore, Carrabetta, Barone, Antonella, Razzano, Monica, Giuseppe, Imperoli, Angela, Bini, Francesco, Serra, Valeria, D'Agostino, Federico, Gianolla, Lucia, Pietrangeli, Antonella, Velardi, Elisabetta, Di Cello, Cristina, Rosati, Nadia, Casali, Maria, Sessa, Luciano, Abruzzi, Chiara, Costanzi, Bini, Paolo, Pignata, Michele, Enrico, Buonagurio, Maria, Vollery, Giovanni, Carrieri, Giorgio, Cioni, Andrea, Toschi, Marco, Metra, Piera, Ranieri, Alberto, Zucchelli, Ceccon, Anna, Magrin, Laura, Marin, Sara, Barbara, Sofia, Marco, Masina, Laura, Ghedini, Matteo, Moroni, Marco, Paragona, Caterina, Pallotti Maria, Carla, Rota, Federica, Gottardi, Clara, Tomasoni, Melania, Cappuccio, Giampaolo, Bonini, Stefano, Guerini, Valeria, Guerini, Lucia, Merla, Giovambattista, Desideri, Ester, Liberatore, Cecilia, Carucci Anna, Maurizio, Tovaglieri, Vera, Renna Frandesca, Nadia, Bongiorni, Grillo, Antonio, Arenare, Francesca, Tonino, Mineo, David, Kanah, Giorgio, Vianello Piero, Ubaldo, Balducci, Vincenzo, Sidoti, Stefano, Montanari, Marino, Formilan, Busonera Flavio, Murelli Teodolindo, Paolo, Albanese, Monica, Maselli, Francesco, Bolzetta, Roberto, Fabris, Paolo, Bonino, DuranteMangoni, Emanuele, Testoni, Michela, Fabio, Di Stefano, Loredana, Seccia, Valeria, Sonzini, Fabiano, Maria, Annabella, Di Giorgio, Salvatore, De Cosmo, Greco, Antonio, Grazia, D'Onofrio, Daniele, Sancarlo, Gianluca, Resta, Renzo, Girardello, Sergio, Minervini, Morena, Boni, Vitali, Mariagrazia, Marina, Pizzoni, Paolo, De Colle, Cristina, Scarpa, Alessandra, Frattola, Orlandini, Francesco, La Regina, Micaela, Desirée, Addesi, Mirella, Filippo, Mario, Bo, Paola, Porrino, Padulo, Filomena, Cristina, Margheriti, Dario, Rolano, Giancarla, Moscatelli, Guido, Radaelli, Elena, Montini, Prete, Cosimo, Marileda, Novello, Igor, Bramuzzo, Nicole, Bertin, Elena, Rinaldo, Paolillo, Ciro, Riccardi, Angela, Claudia, Benedetti, Barbara, Rizzi, Francesca, Montagna, Silvia, Vitali, Chiara, Cutaia, Oliver, Baca, Mauro, Colombo, Eleonora, Marelli, Giuseppe, Procino, Rosaria, Tararà, Maria, Cottino, Davide, Dell'Acqua, Stefania, Cislaghi, Marco, Cairati, Massimo, Porta, Luca, Scaglione, Martina, De Feo, Paola, Vertolli, Lia, Salvati, Sandro, Cinotti, Valentina, De Santis, Erminia, Biferi, Paola, Cheli, Romina, Rebizzo, Minisola, Salvatore, Luciano, Colangelo, Pasquale, Abete, Ilaria, Liguori, Francesca, Curcio, Guglielmo, Spassini, Marco, Engheben, Sara, Rotunno, Paola, Arosio, Claudio, Angelini, Francesco, Reggiani, Alessandro, Cappelli, Simona, Marcheselli, Lara, Fratticci, Paola, Ranzani, Simonetta, Cesarini, Antonella, Cerini, Generoso, Uomo, Fernando, Gallucci, Giuliano, Ceschia, Emanuela, Serra, Mariolina, Sola, Alessandro, Delitala, Chiara, Pes, Giulia, Lobianco, Alessandro, Giani, Famularo, Simone, Sandini, Marta, Pinotti, Enrico, Gianotti, Luca, Antonella, Battuello, Giulia, Pintore, Sante, Giardini, Rossi, Andrea, Rubele, Sofia, Sant, Selena, Marco, Vignati, Danila, Clerici, Fabio, Rosa, Bandirali, Maria Pia, Nicoletta, Cattaneo, Laura, Boffi, Paolo, Tosoni, Luciano, Terranova, Leonello, Avalli, Margherita, Scanziani, Stefania, De Notaris, Pierluigi, Del Santo, Laura, Rossi, Fabiana, Tezza, Giovanna, Cervati, Antonino, Andreolli, Felice, Catalano, Giuseppe, Burattin, Danilo, Fogli, Giovanna, Di Bella, Francesco, Landi, Salini, Sara, Angela, Brunetti Maria, Giorgetta, Cappa, Giovanni, Galvagno, Paola, Cena, Gerardo, Bruno, Silvio, Raspo, Letizia, Semeraro, Sabrina, Pedrotti, Davide, Barra, Rosaria, Rizzo Maria, Maria, Dalise Anna, Raffaele, Prestano, Palmieri, Vincenzo Ostilio, Palasciano, Giuseppe, Belfiore, Anna, Portincasa, Piero, Carlo, Sabbà, Vincenzo, Solfrizzi, Alessia, D'introno, Valiani, Vincenzo, Carolina, Bologna, Tiziana, Ciarambino, Paola, Turelli, Ugo, Pazzaglia, Federica, Rodella, Giacomo, Piana, Castellano, Maurizio, Anna, Garelli, Elisa, Casella, Federica, Campana, Antonietta, Coschignano Maria, Luigi, Marinangeli, Fabio, Lorico, Salvatore, Bazzano, Giuseppe, Menculini, Gelosa, Giorgio, Viviana, Ambrogio Teresa, Piras, Valentina, Andrea, Ciricugno, Alessandra, Bollari, Coen, Daniele, Magliola, Renata, Milanesio, Deborah, Muzzulini, Carlo Lorenzo, Paolo, Fogliacco, Marinella, Turla, Sofia, Cotelli Maria, Marta, Bianchi, Siano, Pietro, Capo, Giuseppe, Napoletano, Rosa, Cecilia, Politi, Mancini, Concetta, Del Buono, Corrado, De Bartolomeo, Giuseppe, Addolorata, Martinelli, Carmen, Cefalogli, Roberto, Cozzi, Giovanni, Virtuani Angelo, Moschettini, Gianfilippo, Franco, Mastroianni, Daniela, Roglia, D'Amico, Gabriella, Mirella, Palella, Endrizzi, Cristina, Trotta, Lucia, Ciarambino, Tiziana, Orazio, Zanetti, Emanuela, Terazzi, Marta, Sacchetti, Thomas, Fleetwood, Giacomo, Tondo, Ignazio, Di Fazio, Andrea, Bruni, Giuseppe, Orsitto, Emanuela, Fabbro, Serena, Amici, Elena, D'Imporzano, Anna, Casanova, Serena, Bertolio, Erika, Nervo, Roberto, Silvestri, Elena, Semproni, Manuela, Pintus, Francesca, Aloe, Angelo, Tagliaccica, Zambon, Antonella, and Di Santo, Simona G.

Published
2020
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18. Single large hepatocellular carcinoma > 5 cm with surgical indication: is it mandatory a major hepatectomy? a propensity-score weighted analysis.

Author

Garancini, Mattia, Serenari, Matteo, Famularo, Simone, Cipriani, Federica, Ardito, Francesco, Russolillo, Nadia, Conci, Simone, Nicolini, Daniele, Perri, Pasquale, Zanello, Matteo, Iaria, Maurizio, Lai, Quirino, Romano, Maurizio, La Barba, Giuliano, Molfino, Sarah, Germani, Paola, Dominioni, Tommaso, Zimmiti, Giuseppe, Conticchio, Maria, and Fumagalli, Luca

Subjects
*SURGICAL indications, *HEPATOCELLULAR carcinoma, *OVERALL survival, *HEPATECTOMY, *RETROSPECTIVE studies
Abstract

Purpose: Single large hepatocellular carcinoma >5cm (SLHCC) traditionally requires a major liver resection. Minor resections are often performed with the goal to reduce morbidity and mortality. Aim of the study was to establish if a major resection should be considered the best treatment for SLHCC or a more limited resection should be preferred. Methods: A multicenter retrospective analysis of the HE.RC.O.LE.S. Group register was performed. All collected patients with surgically treated SLHCC were divided in 5 groups of treatment (major hepatectomy, sectorectomy, left lateral sectionectomy, segmentectomy, non-anatomical resection) and compared for baseline characteristics, short and long-term results. A propensity-score weighted analysis was performed. Results: 535 patients were enrolled in the study. Major resection was associated with significantly increased major complications compared to left lateral sectionanectomy, segmentectomy and non-anatomical resection (all p<0.05) and borderline significant increased major complications compared to sectorectomy (p=0.08). Left lateral sectionectomy showed better overall survival compared to major resection (p=0.02), while other groups of treatment resulted similar to major hepatectomy group for the same item. Absence of oncological benefit after major resection and similar outcomes among the 5 groups of treatment was confirmed even in the sub-population excluding patients with macrovascular invasion. Conclusion: Major resection was associated to increased major post-operative morbidity without long-term survival benefit; when technically feasible and oncologically adequate, minor resections should be preferred for the surgical treatment of SLHCC. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Survival benefit of second line therapies for recurrent hepatocellular carcinoma: repeated hepatectomy, thermoablation and second-line transplant referral in a real life national scenario

Author

Famularo, Simone, primary, Cillo, Umberto, additional, Lauterio, Andrea, additional, Donadon, Matteo, additional, Vitale, Alessandro, additional, Serenari, Matteo, additional, Cipriani, Federica, additional, Fazio, Federico, additional, Giuffrida, Mario, additional, Ardito, Francesco, additional, Dominioni, Tommaso, additional, Garancini, Mattia, additional, Lai, Quirino, additional, Nicolini, Daniele, additional, Molfino, Sarah, additional, Perri, Pasquale, additional, Pinotti, Enrico, additional, Conci, Simone, additional, Ferrari, Cecilia, additional, Zanello, Matteo, additional, Patauner, Stefan, additional, Zimmitti, Giuseppe, additional, Germani, Paola, additional, Chiarelli, Marco, additional, Romano, Maurizio, additional, De Angelis, Michela, additional, La Barba, Giuliano, additional, Troci, Albert, additional, Ferraro, Valentina, additional, Izzo, Francesco, additional, Antonucci, Adelmo, additional, Belli, Andrea, additional, Memeo, Riccardo, additional, Crespi, Michele, additional, Ercolani, Giorgio, additional, Boccia, Luigi, additional, Zanus, Giacomo, additional, Tarchi, Paola, additional, Hilal, Moh'd Abu, additional, Frena, Antonio, additional, Jovine, Elio, additional, Griseri, Guido, additional, Ruzzenente, Andrea, additional, Zago, Mauro, additional, Grazi, Gianluca, additional, Baiocchi, Gian L., additional, Vivarelli, Marco, additional, Rossi, Massimo, additional, Romano, Fabrizio, additional, Maestri, Marcello, additional, Giuliante, Felice, additional, Valle, Raffaele D., additional, Ferrero, Alessandro, additional, Aldrighetti, Luca, additional, De Carlis, Luciano, additional, Cescon, Matteo, additional, Torzilli, Guido, additional, Milana, Flavio, additional, Bertacco, Alessandra, additional, De Carlis, Riccardo, additional, Ratti, Francesca, additional, Russolillo, Nadia, additional, Iaria, Maurizio, additional, Razionale, Francesco, additional, Tartaglia, Giuseppe, additional, Ciulli, Cristina, additional, Carissimi, Francesca, additional, Laureiro, Zoe L., additional, Marinelli, Laura, additional, DePeppo, Valerio, additional, Montuori, Mauro, additional, Marchitelli, Ivan, additional, Franceschi, Angelo, additional, Notte, Francesca, additional, Manzoni, Alberto, additional, Cosola, Davide, additional, Corleone, Pio, additional, Fumagalli, Luca, additional, Salvador, Luca, additional, Mantovani, Guido, additional, Cucchetti, Alessandro, additional, Cammarata, Francesco, additional, Conticchio, Maria, additional, Patrone, Renato, additional, and Bernasconi, Davide P., additional

Published
2023
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22. Dynamic surgical anatomy using 3D reconstruction technology in complex hepato-biliary surgery with vascular involvement. Results from an international multicentric survey

Author

Cotsoglou, Christian, primary, Granieri, Stefano, additional, Bassetto, Serena, additional, Bagnardi, Vincenzo, additional, Pugliese, Raffaele, additional, Grazi, Gian Luca, additional, Guglielmi, Alfredo, additional, Ruzzenente, Andrea, additional, Aldrighetti, Luca, additional, Ratti, Francesca, additional, De Carlis, Luciano, additional, De Carlis, Riccardo, additional, Centonze, Leonardo, additional, De Angelis, Nicola, additional, Memeo, Riccardo, additional, Delvecchio, Antonella, additional, Felli, Emanuele, additional, Izzo, Francesco, additional, Belli, Andrea, additional, Patrone, Renato, additional, Ettorre, Giuseppe Maria, additional, Berardi, Giammauro, additional, Di Benedetto, Fabrizio, additional, Di Sandro, Stefano, additional, Romano, Fabrizio, additional, Garancini, Mattia, additional, Scotti, Mauro Alessandro, additional, Bianchi, Giorgio, additional, Germini, Alessandro, additional, Gjoni, Elson, additional, Bonomi, Alessandro, additional, Bruno, Federica, additional, Paleino, Sissi, additional, and Pugliese, Giacomo, additional

Published
2023
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23. Early compliance to the Enhanced Recovery After Surgery (ERAS) in liver surgery: a proposal to clarify the cause-effect relationship with clinical outcome

Author

Ciulli, Cristina, primary, Fogliati, Alessandro, additional, Benedetti, Fabio, additional, Carissimi, Francesca, additional, Scotti, Mauro, additional, Aprigliano, Michele, additional, Famularo, Simone, additional, Gianotti, Luca, additional, Braga, Marco, additional, Romano, Fabrizio, additional, and Garancini, Mattia, additional

Published
2023
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24. Liver Resection vs Nonsurgical Treatments for Patients With Early Multinodular Hepatocellular Carcinoma

Author

Vitale, Alessandro, Romano, Pierluigi, Cillo, Umberto, Lauterio, Andrea, Sangiovanni, Angelo, Cabibbo, Giuseppe, Missale, Gabriele, Marseglia, Mariarosaria, Trevisani, Franco, Foschi, Francesco Giuseppe, Cipriani, Federica, Famularo, Simone, Marra, Fabio, Saitta, Carlo, Serenari, Matteo, Vidili, Gianpaolo, Morisco, Filomena, Caturelli, Eugenio, Mega, Andrea, Pelizzaro, Filippo, Nicolini, Daniele, Ardito, Francesco, Garancini, Mattia, Masotto, Alberto, Baroni, Gianluca Svegliati, Azzaroli, Francesco, Giannini, Edoardo, Perri, Pasquale, Scarinci, Andrea, Fontana, Andrea Pierluigi, Brunetto, Maurizia Rossana, Iaria, Maurizio, Di Marco, Maria, Nardone, Gerardo, Dominioni, Tommaso, Lai, Quirino, Ferrari, Cecilia, Rapaccini, Gian Ludovico, Rodolfo, Sacco, Romano, Maurizio, Conci, Simone, Zoli, Marco, Conticchio, Maria, Zanello, Matteo, Zimmitti, Giuseppe, Fumagalli, Luca, Troci, Albert, Germani, Paola, Gasbarrini, Antonio, La Barba, Giuliano, De Angelis, Michela, Patauner, Stefan, Molfino, Sarah, Zago, Mauro, Pinotti, Enrico, Frigo, Anna Chiara, Baiocchi, Gian Luca, Frena, Antonio, Boccia, Luigi, Ercolani, Giorgio, Tarchi, Paola, Crespi, Michele, Chiarelli, Marco, Abu Hilal, Moh’d, Cescon, Matteo, Memeo, Riccardo, Ruzzenente, Andrea, Zanus, Giacomo, Griseri, Guido, Rossi, Massimo, Maestri, Marcello, Della Valle, Raffaele, Ferrero, Alessandro, Grazi, Gian Luca, Romano, Fabrizio, Giuliante, Felice, Vivarelli, Marco, Jovine, Elio, Torzilli, Guido, Aldrighetti, Luca, and De Carlis, Luciano

Abstract

IMPORTANCE: The 2022 Barcelona Clinic Liver Cancer algorithm currently discourages liver resection (LR) for patients with multinodular hepatocellular carcinoma (HCC) presenting with 2 or 3 nodules that are each 3 cm or smaller. OBJECTIVE: To compare the efficacy of liver resection (LR), percutaneous radiofrequency ablation (PRFA), and transarterial chemoembolization (TACE) in patients with multinodular HCC. DESIGN, SETTING, AND PARTICIPANTS: This cohort study is a retrospective analysis conducted using data from the HE.RC.O.LE.S register (n = 5331) for LR patients and the ITA.LI.CA database (n = 7056) for PRFA and TACE patients. A matching-adjusted indirect comparison (MAIC) method was applied to balance data and potential confounding factors between the 3 groups. Included were patients from multiple centers from 2008 to 2020; data were analyzed from January to December 2023. INTERVENTIONS: LR, PRFA, or TACE. MAIN OUTCOMES AND MEASURES: Survival rates at 1, 3, and 5 years were calculated. Cox MAIC-weighted multivariable analysis and competing risk analysis were used to assess outcomes. RESULTS: A total of 720 patients with early multinodular HCC were included, 543 males (75.4%), 177 females (24.6%), and 350 individuals older than 70 years (48.6%). There were 296 patients in the LR group, 240 who underwent PRFA, and 184 who underwent TACE. After MAIC, LR exhibited 1-, 3-, and 5-year survival rates of 89.11%, 70.98%, and 56.44%, respectively. PRFA showed rates of 94.01%, 65.20%, and 39.93%, while TACE displayed rates of 90.88%, 48.95%, and 29.24%. Multivariable Cox survival analysis in the weighted population showed a survival benefit over alternative treatments (PRFA vs LR: hazard ratio [HR], 1.41; 95% CI, 1.07-1.86; P = .01; TACE vs LR: HR, 1.86; 95% CI, 1.29-2.68; P = .001). Competing risk analysis confirmed a lower risk of cancer-related death in LR compared with PRFA and TACE. CONCLUSIONS AND RELEVANCE: For patients with early multinodular HCC who are ineligible for transplant, LR should be prioritized as the primary therapeutic option, followed by PRFA and TACE when LR is not feasible. These findings provide valuable insights for clinical decision-making in this patient population.

Published
2024
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29. The Complex Cyto-Molecular Landscape of Thyroid Nodules in Pediatrics

Author

Seminati, D, Ceola, S, Pincelli, A, Leni, D, Gatti, A, Garancini, M, L'Imperio, V, Cattoni, A, Pagni, F, Seminati, Davide, Ceola, Stefano, Pincelli, Angela Ida, Leni, Davide, Gatti, Andrea, Garancini, Mattia, L'Imperio, Vincenzo, Cattoni, Alessandro, Pagni, Fabio, Seminati, D, Ceola, S, Pincelli, A, Leni, D, Gatti, A, Garancini, M, L'Imperio, V, Cattoni, A, Pagni, F, Seminati, Davide, Ceola, Stefano, Pincelli, Angela Ida, Leni, Davide, Gatti, Andrea, Garancini, Mattia, L'Imperio, Vincenzo, Cattoni, Alessandro, and Pagni, Fabio

Abstract

Thyroid fine-needle aspiration (FNA) is a commonly used diagnostic cytological procedure in pediatric patients for the evaluation of thyroid nodules, triaging them for the detection of thyroid cancer. In recent years, greater attention has been paid to thyroid FNA in this setting, including the use of updated ultrasound score algorithms to improve accuracy and yield, especially considering the theoretically higher risk of malignancy of these lesions compared with the adult population, as well as to minimize patient discomfort. Moreover, molecular genetic testing for thyroid disease is an expanding field of research that could aid in distinguishing benign from cancerous nodules and assist in determining their clinical management. Finally, artificial intelligence tools can help in this task by performing a comprehensive analysis of all the obtained data. These advancements have led to greater reliance on FNA as a first-line diagnostic tool for pediatric thyroid disease. This review article provides an overview of these recent developments and their impact on the diagnosis and management of thyroid nodules in children.

Published
2023

30. Spatially Resolved Molecular Approaches for the Characterisation of Non-Invasive Follicular Tumours with Papillary-like Features (NIFTPs)

Author

Piga, I, L'Imperio, V, Principi, L, Bellevicine, C, Fusco, N, Maffini, F, Venetis, K, Ivanova, M, Seminati, D, Casati, G, Pagani, L, Galimberti, S, Capitoli, G, Garancini, M, Gatti, A, Magni, F, Pagni, F, Piga, Isabella, L'Imperio, Vincenzo, Principi, Lucrezia, Bellevicine, Claudio, Fusco, Nicola, Maffini, Fausto, Venetis, Konstantinos, Ivanova, Mariia, Seminati, Davide, Casati, Gabriele, Pagani, Lisa, Galimberti, Stefania, Capitoli, Giulia, Garancini, Mattia, Gatti, Andrea-Valer, Magni, Fulvio, Pagni, Fabio, Piga, I, L'Imperio, V, Principi, L, Bellevicine, C, Fusco, N, Maffini, F, Venetis, K, Ivanova, M, Seminati, D, Casati, G, Pagani, L, Galimberti, S, Capitoli, G, Garancini, M, Gatti, A, Magni, F, Pagni, F, Piga, Isabella, L'Imperio, Vincenzo, Principi, Lucrezia, Bellevicine, Claudio, Fusco, Nicola, Maffini, Fausto, Venetis, Konstantinos, Ivanova, Mariia, Seminati, Davide, Casati, Gabriele, Pagani, Lisa, Galimberti, Stefania, Capitoli, Giulia, Garancini, Mattia, Gatti, Andrea-Valer, Magni, Fulvio, and Pagni, Fabio

Abstract

Noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP) are low-risk thyroid lesions most often characterised by RAS-type mutations. The histological diagnosis may be challenging, and even immunohistochemistry and molecular approaches have not yet provided conclusive solutions. This study characterises a set of NIFTPs by Matrix-Assisted Laser Desorption/Ionisation (MALDI)-Mass Spectrometry Imaging (MSI) to highlight the proteomic signatures capable of overcoming histological challenges. Archived formalin-fixed paraffin-embedded samples from 10 NIFTPs (n = 6 RAS-mutated and n = 4 RAS-wild type) were trypsin-digested and analysed by MALDI-MSI, comparing their profiles to normal tissue and synchronous benign nodules. This allowed the definition of a four-peptide signature able to distinguish RAS-mutant from wild-type cases, the latter showing proteomic similarities to hyperplastic nodules. Moreover, among the differentially expressed signals, Peptidylprolyl Isomerase A (PPIA, 1505.8 m/z), which has already demonstrated a role in the development of cancer, was found overexpressed in NIFTP RAS-mutated nodules compared to wild-type lesions. These results underlined that high-throughput proteomic approaches may add a further level of biological comprehension for NIFTPs. In the future, thanks to the powerful single-cell detail achieved by new instruments, the complementary NGS-MALDI imaging sequence might be the correct methodological approach to confirm that the current NIFTP definition encompasses heterogeneous lesions that must be further characterised.

Published
2023

33. Spatially Resolved Molecular Approaches for the Characterisation of Non-Invasive Follicular Tumours with Papillary-like Features (NIFTPs)

Author

Piga, Isabella, primary, L’Imperio, Vincenzo, additional, Principi, Lucrezia, additional, Bellevicine, Claudio, additional, Fusco, Nicola, additional, Maffini, Fausto, additional, Venetis, Konstantinos, additional, Ivanova, Mariia, additional, Seminati, Davide, additional, Casati, Gabriele, additional, Pagani, Lisa, additional, Galimberti, Stefania, additional, Capitoli, Giulia, additional, Garancini, Mattia, additional, Gatti, Andrea-Valer, additional, Magni, Fulvio, additional, and Pagni, Fabio, additional

Published
2023
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34. How future surgery will benefit from SARS-COV-2-related measures: a SPIGC survey conveying the perspective of Italian surgeons.

Author

Siragusa, Leandro, Angelico, Roberta, Angrisani, Marco, Zampogna, Biagio, Materazzo, Marco, Sorge, Roberto, Giordano, Luca, Meniconi, Roberto, Coppola, Alessandro, Marino, Annarita, Giraudo, Giorgio, Esposito, Sofia, Urbani, Alessia, De Pastena, Matteo, Mastrapasqua, Rodolfo, Garancini, Mattia, Frontal, Alice, Pascal, Giovanni, Martellucc, Jacopo, and Falb, Francesco

Abstract

COVID-19 negatively affected surgical activity, but the potential benefits resulting from adopted measures remain unclear. The aim of this study was to evaluate the change in surgical activity and potential benefit from COVID-19 measures in perspective of Italian surgeons on behalf of SPIGC. A nationwide online survey on surgical practice before, during, and after COVID-19 pandemic was conducted in March–April 2022 (NCT:05323851). Effects of COVID-19 hospital-related measures on surgical patients' management and personal professional development across surgical specialties were explored. Data on demographics, pre-operative/peri-operative/post-operative management, and professional development were collected. Outcomes were matched with the corresponding volume. Four hundred and seventy-three respondents were included in final analysis across 14 surgical specialties. Since SARS-CoV-2 pandemic, application of telematic consultations (4.1% vs. 21.6%; p < 0.0001) and diagnostic evaluations (16.4% vs. 42.2%; p < 0.0001) increased. Elective surgical activities significantly reduced and surgeons opted more frequently for conservative management with a possible indication for elective (26.3% vs. 35.7%; p < 0.0001) or urgent (20.4% vs. 38.5%; p < 0.0001) surgery. All new COVID-related measures are perceived to be maintained in the future. Surgeons' personal education online increased from 12.6% (pre-COVID) to 86.6% (post-COVID; p < 0.0001). Online educational activities are considered a beneficial effect from COVID pandemic (56.4%). COVID-19 had a great impact on surgical specialties, with significant reduction of operation volume. However, some forced changes turned out to be benefits. Isolation measures pushed the use of telemedicine and telemetric devices for outpatient practice and favored communication for educational purposes and surgeon–patient/family communication. From the Italian surgeons' perspective, COVID-related measures will continue to influence future surgical clinical practice. [ABSTRACT FROM AUTHOR]

Published
2023
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35. An Indeterminate for Malignancy FNA Report Does Not Increase the Surgical Risk of Incidental Thyroid Carcinoma

Author

Seminati, Davide, primary, Mane, Eltjona, additional, Ceola, Stefano, additional, Casati, Gabriele, additional, Putignano, Pietro, additional, Garancini, Mattia, additional, Gatti, Andrea, additional, Leni, Davide, additional, Pincelli, Angela Ida, additional, Fusco, Nicola, additional, L’Imperio, Vincenzo, additional, and Pagni, Fabio, additional

Published
2022
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36. Association of indirect measurement of cell function by bioimpedance analysis with complications in oncologic hepatic surgery

Author

Famularo, Simone, primary, Donadon, Matteo, additional, Roccamatisi, Linda, additional, Di Lucca, Gabriele, additional, Angrisani, Marco, additional, Baccalini, Edoardo, additional, Franchi, Eloisa, additional, Corleone, Pio, additional, Garancini, Mattia, additional, Sandini, Marta, additional, Braga, Marco, additional, Torzilli, Guido, additional, and Gianotti, Luca, additional

Published
2022
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39. The largest western experience on salvage hepatectomy for recurrent hepatocellular carcinoma: propensity score-matched analysis on behalf of He.RC.O.Le.Study Group

Author

Iaria, Maurizio, primary, Bianchi, Giorgio, additional, Fazio, Federico, additional, Ardito, Francesco, additional, Perri, Pasquale, additional, Pontarolo, Nicholas, additional, Conci, Simone, additional, Donadon, Matteo, additional, Zanello, Matteo, additional, Lai, Quirino, additional, Famularo, Simone, additional, Molfino, Sarah, additional, Sciannamea, Ivano, additional, Fumagalli, Luca, additional, Germani, Paola, additional, Floridi, Antonio, additional, Ferrari, Cecilia, additional, Zimmitti, Giuseppe, additional, Troci, Albert, additional, Zago, Mauro, additional, Ferraro, Valentina, additional, Cipriani, Federica, additional, Patauner, Stefan, additional, La Barba, Giuliano, additional, Romano, Maurizio, additional, Zanus, Giacomo, additional, Ercolani, Giorgio, additional, Frena, Antonio, additional, Aldrighetti, Luca, additional, Memeo, Riccardo, additional, Pinotti, Enrico, additional, Crespi, Michele, additional, Hilal, Moh'd Abu, additional, Griseri, Guido, additional, Tarchi, Paola, additional, Chiarelli, Marco, additional, Antonucci, Adelmo, additional, Baiocchi, Gian L., additional, Romano, Fabrizio, additional, Rossi, Massimo, additional, Jovine, Elio, additional, Torzilli, Guido, additional, Ruzzenente, Andrea, additional, Maestri, Marcello, additional, Grazi, Gian L., additional, Giuliante, Felice, additional, Ferrero, Alessandro, additional, Dalla Valle, Raffaele, additional, Giuffrida, Mario, additional, Russolillo, Nadia, additional, Razionale, Francesco, additional, De Peppo, Valerio, additional, Tomasoni, Matteo, additional, Marchitelli, Ivan, additional, Costa, Guido, additional, Laureiro, Zoe L., additional, Scotti, Mauro, additional, Calcagno, Pietro, additional, Cosola, Davide, additional, Franceschi, Angelo, additional, Manzoni, Alberto, additional, Pennacchi, Luca, additional, Montuori, Mauro, additional, Conticchio, Maria, additional, Ratti, Francesca, additional, Notte, Francesca, additional, Cucchetti, Alessandro, additional, Salvador, Luca, additional, Corleone, Pio, additional, Garancini, Mattia, additional, and Ciulli, Cristina, additional

Published
2022
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42. COVID-19 and Liver Surgery: How the Pandemic Affected an Italian Medium-Volume HBP Center

Author

Carissimi, F, Scotti, M, Ciulli, C, Fogliati, A, Uggeri, F, Chiarelli, M, Braga, M, Romano, F, Garancini, M, Carissimi, Francesca, Scotti, Mauro Alessandro, Ciulli, Cristina, Fogliati, Alessandro, Uggeri, Fabio, Chiarelli, Marco, Braga, Marco, Romano, Fabrizio, Garancini, Mattia, Carissimi, F, Scotti, M, Ciulli, C, Fogliati, A, Uggeri, F, Chiarelli, M, Braga, M, Romano, F, Garancini, M, Carissimi, Francesca, Scotti, Mauro Alessandro, Ciulli, Cristina, Fogliati, Alessandro, Uggeri, Fabio, Chiarelli, Marco, Braga, Marco, Romano, Fabrizio, and Garancini, Mattia

Abstract

Introduction: While the COVID-19 pandemic is still ongoing, it is even more evident that victims of the pandemic are not only those who contract the virus, but also the countless patients suffering from other serious diseases (i.e., tumor) who have undergone delayed potentially life-saving surgery due to a lack of beds. Like many hospitals, ours also initially blocked all elective oncologic surgery, but these operations were “recovered” and reintegrated in a relatively short time, thanks to the establishment of COVID-free wards and operating rooms with staff dedicated to oncological surgery. In tis context, our aim is to assess whether and how the severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) pandemic has impacted our hepatobiliary surgery unit. Methods: From our prospective database, we retrospectively took data from patients undergoing liver surgery in 2018–2019 (pre-COVID) and 2020–2021 (COVID period). Patients admitted to COVID-free wards must necessarily have a negative nasal swab from the previous 24 h. Results: Between January 1, 2018, and December 31, 2019 (Group 1), 101 patients were treated; during the pandemic [January 1, 2020, and December 31, 2021 (Group 2)], 126 patients were treated. There was no statistical difference between the groups. The median postoperative hospital stay was 7 days for both groups; 7 patients had major complications (Clavien-Dindo > 3) in Group 1 and 11 in Group 2 (p = 0.795). A total of 4 patients died in Group 1 and 6 during the pandemic (p = 0.754). Tumor burden was significantly greater in Group 2 where nodule size, lymphadenectomy, and extrahepatic disease were significantly greater (p = 0.011, p = 0.004, and p = 0.026, respectively). Conclusion: During the COVID pandemic, our HPB unit managed to offer a volume of tertiary-center hepatobiliary surgery without a significant impact in terms of length of stay, morbidity, or mortality despite the increase in tumor burden during the pandemic years.

Published
2022

43. An Indeterminate for Malignancy FNA Report Does Not Increase the Surgical Risk of Incidental Thyroid Carcinoma

Author

Seminati, D, Mane, E, Ceola, S, Casati, G, Putignano, P, Garancini, M, Gatti, A, Leni, D, Pincelli, A, Fusco, N, L'Imperio, V, Pagni, F, Seminati, Davide, Mane, Eltjona, Ceola, Stefano, Casati, Gabriele, Putignano, Pietro, Garancini, Mattia, Gatti, Andrea, Leni, Davide, Pincelli, Angela Ida, Fusco, Nicola, L'Imperio, Vincenzo, Pagni, Fabio, Seminati, D, Mane, E, Ceola, S, Casati, G, Putignano, P, Garancini, M, Gatti, A, Leni, D, Pincelli, A, Fusco, N, L'Imperio, V, Pagni, F, Seminati, Davide, Mane, Eltjona, Ceola, Stefano, Casati, Gabriele, Putignano, Pietro, Garancini, Mattia, Gatti, Andrea, Leni, Davide, Pincelli, Angela Ida, Fusco, Nicola, L'Imperio, Vincenzo, and Pagni, Fabio

Abstract

Incidental thyroid carcinomas (ITCs) are a fairly frequent finding in daily routine practice, with papillary thyroid microcarcinoma being the most frequent entity. In our work, we isolated incidental cases arising in thyroids removed for other cytologically indeterminate and histologically benign nodules. We retrospectively retrieved cases with available thyroid Fine Needle Aspiration (FNA, 3270 cases), selecting those with an indeterminate cytological diagnosis (Bethesda classes III–IV, 652 cases). Subsequently, we restricted the analysis to surgically treated patients (163 cases) finding an incidental thyroid carcinoma in 22 of them. We found a 13.5% ITC rate, with ITCs representing 46.8% of all cancer histologically diagnosed in this indeterminate setting. Patients received a cytological diagnosis of Bethesda class III and IV in 41% and 59% of cases, respectively. All ITC cases turned out to be papillary thyroid microcarcinomas; 36% of cases were multifocal, with foci bilaterally detected in 50% of cases. We found an overall ITC rate concordant with the literature and with our previous findings. The assignment of an indeterminate category to FNA did not increase the risk of ITCs in our cohort. Rather, a strong statistical significance (p < 0.01) was found comparing the larger size of nodules that underwent FNA and the smaller size of their corresponding ITC nodule.

Published
2022

44. Pancreatic Cystic Neoplasms and Pregnancy: A Systematic Review of Surgical Cases and a Case Report of a Fully Laparoscopic Distal Pancreatectomy

Author

Fogliati, A, Garancini, M, Uggeri, F, Braga, M, Gianotti, L, Fogliati, Alessandro, Garancini, Mattia, Uggeri, Fabio, Braga, Marco, Gianotti, Luca, Fogliati, A, Garancini, M, Uggeri, F, Braga, M, Gianotti, L, Fogliati, Alessandro, Garancini, Mattia, Uggeri, Fabio, Braga, Marco, and Gianotti, Luca

Abstract

Background: Mucinous cystic neoplasms and solid pseudopapillary neoplasms are the most common pancreatic tumors occurring in women of fertile age and in pregnant women. The aim of this study is to provide an updated literature review on this association and to present a fully laparoscopic resection of a pregnancy-associated pancreatic cystic neoplasm. Materials and methods: A systematic literature review was performed using PubMed (MEDLINE), Scopus, Ovid, ISI Web of Science, and Google Scholar for searching. The syntax was (pancr*) AND (cyst*) AND (pregn*) AND (tumor). Only English-language articles describing pancreatic surgical resections were included. Results: Forty-seven case reports were included. The mean age of the patients was 29.6±5.3. Nine patients (20%) required emergency surgery, 4 (9%) due to cyst rupture, and 5 (11%) due to hemorrhage. Four patients (9%) suffered a miscarriage, and 2 (5%) opted for pregnancy termination; the rest of the women delivered a healthy newborn (86%, n=36). Thirty percent (n=14) of the resected neoplasms were malignant, and among mucinous cystic lesions, this raised to 45% (n=11). All patients diagnosed during the third trimester were resected postpartum, whereas 26/34 (76%) of patients diagnosed during the first 2 trimesters underwent surgery before delivery. Conclusions: The most worrisome complications in pregnancy-associated pancreatic cysts are bleeding or rupture. Mucinous cystic neoplasm has a tendency to grow during pregnancy. A postpartum resection was generally preferred when the cystic neoplasm was diagnosed during the third trimester. This report is the first to describe a fully laparoscopic pancreatic resection.

Published
2022

45. Branching patterns of the left portal vein and consequent implications in liver surgery: The left anterior sector

Author

Garancini, M, Scotti, M, Gianotti, L, Rovere, A, Uggeri, F, Braga, M, Romano, F, Garancini, Mattia, Scotti, Mauro Alessandro, Gianotti, Luca, Rovere, Antonio, Uggeri, Fabio, Braga, Marco, Romano, Fabrio, Garancini, M, Scotti, M, Gianotti, L, Rovere, A, Uggeri, F, Braga, M, Romano, F, Garancini, Mattia, Scotti, Mauro Alessandro, Gianotti, Luca, Rovere, Antonio, Uggeri, Fabio, Braga, Marco, and Romano, Fabrio

Published
2022

46. Left Anterior Sectorectomy: An Alternative to Left Hepatectomy for Tumors Invading the Distal Part of the Left Portal Vein

Author

Garancini, M, Scotti, M, Gianotti, L, Ciulli, C, Carissimi, F, Uggeri, F, Degrate, L, Braga, M, Romano, F, Garancini, Mattia, Scotti, Mauro Alessandro, Gianotti, Luca, Ciulli, Cristina, Carissimi, Francesca, Uggeri, Fabio, Degrate, Luca, Braga, Marco, Romano, Fabrizio, Garancini, M, Scotti, M, Gianotti, L, Ciulli, C, Carissimi, F, Uggeri, F, Degrate, L, Braga, M, Romano, F, Garancini, Mattia, Scotti, Mauro Alessandro, Gianotti, Luca, Ciulli, Cristina, Carissimi, Francesca, Uggeri, Fabio, Degrate, Luca, Braga, Marco, and Romano, Fabrizio

Abstract

Background: Liver tumors invading the distal part of the umbilical portion of the left portal vein usually require left hepatectomy. The recent introduction of the concept of left anterior sector, an independent anatomo-functional unit including the anterior portion of the left liver and supplied by the distal part of the umbilical portion of the left portal vein, could represent the rational for an alternative surgical approach. The aim of this study was to introduce the novel surgical procedure of ultrasound-guided left anterior sectorectomy. Methods: Among 92 consecutive patients who underwent hepatectomy, 3 patients with tumor invading the distal part of the umbilical portion of the left portal (two with colorectal liver metastases and one with neuroendocrine tumor liver metastases) underwent left anterior sectorectomy alone or in association with liver multiple metastasectomies. Results: Mean operation time was 393 min; post-operative morbidity and mortality were not observed. After a mean FU of 23 months (range 19–28), no local recurrence occurred. Conclusions: In presence of tumors invading the distal part of the umbilical portion of the left portal, left anterior sectorectomy could be considered as an anatomic radical surgical option that is safe but more conservative than a left hepatectomy.

Published
2022

47. Lights on HBME-1: the elusive biomarker in thyroid cancer pathology

Author

Cazzaniga, G, Seminati, D, Smith, A, Piga, I, Capitoli, G, Garancini, M, L'Imperio, V, Fusco, N, Pagni, F, Cazzaniga, Giorgio, Seminati, Davide, Smith, Andrew, Piga, Isabella, Capitoli, Giulia, Garancini, Mattia, L'Imperio, Vincenzo, Fusco, Nicola, Pagni, Fabio, Cazzaniga, G, Seminati, D, Smith, A, Piga, I, Capitoli, G, Garancini, M, L'Imperio, V, Fusco, N, Pagni, F, Cazzaniga, Giorgio, Seminati, Davide, Smith, Andrew, Piga, Isabella, Capitoli, Giulia, Garancini, Mattia, L'Imperio, Vincenzo, Fusco, Nicola, and Pagni, Fabio

Abstract

Among the different ancillary immunohistochemical tools that pathologists may employ in thyroid nodules, the so-called Hector Battifora's 'MEsothelioma' 1 (HBME-1) staining is one of the most fascinating, since its real identity is currently unknown. In the present review, the different clinical applications of HBME-1 are analysed, with main emphasis on its role in thyroid pathology with overview on less impactful fields, such as haematopathology or mesothelial lesions. Different acceptable or good diagnostic performances were recorded for HBME-1 in thyroid pathology, being used in routine practice as one of the best tools to screen thyroid malignancy both in terms of sensitivity and specificity. From a speculative point of view, after many attempts to hunt the cryptic target antigen of this antibody, its identity still remains elusive. In this setting, the application of high-throughput technologies (mainly in situ proteomics) may be the exact route to improve the knowledge about the pathophysiology of HBME-1 and to finally unveil its true identity.

Published
2022

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