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1. Factors Associated with and Impact of Open Conversion in Laparoscopic and Robotic Minor Liver Resections: An International Multicenter Study of 10,541 Patients

Author

Saleh, Mansour, Pascual, Franco, Ghallab, Mohammed, Wu, Andrew G. R., Chin, Ken-Min, Ratti, Francesca, Giglio, Mariano Cesare, Garatti, Marco, Nghia, Phan Phuoc, Kato, Yutaro, Lim, Chetana, Herman, Paulo, Coelho, Fabricio Ferreira, Schmelzle, Moritz, Pratschke, Johann, Aghayan, Davit L., Liu, Qiu, Marino, Marco V., Belli, Andrea, Chiow, Adrian K. H., Sucandy, Iswanto, Ivanecz, Arpad, Di Benedetto, Fabrizio, Choi, Sung Hoon, Lee, Jae Hoon, Park, James O., Prieto, Mikel, Guzman, Yoelimar, Fondevila, Constantino, Efanov, Mikhail, Rotellar, Fernando, Choi, Gi-Hong, Robles-Campos, Ricardo, Kadam, Prashant, Sutcliffe, Robert P., Troisi, Roberto I., Tang, Chung Ngai, Chong, Charing C., D’Hondt, Mathieu, Dalla Valle, Bernardo, Ruzzenente, Andrea, Kingham, T. Peter, Scatton, Olivier, Liu, Rong, Mejia, Alejandro, Mishima, Kohei, Wakabayashi, Go, Lopez-Ben, Santiago, Wang, Xiaoying, Ferrero, Alessandro, Ettorre, Giuseppe Maria, Vivarelli, Marco, Mazzaferro, Vincenzo, Giuliante, Felice, Yong, Chee Chien, Yin, Mengqiu, Monden, Kazuteru, Geller, David, Chen, Kuo-Hsin, Sugioka, Atsushi, Edwin, Bjørn, Cheung, Tan-To, Long, Tran Cong Duy, Abu Hilal, Mohammad, Aldrighetti, Luca, Soubrane, Olivier, Fuks, David, Han, Ho-Seong, Cherqui, Daniel, and Goh, Brian K. P.

Published
2024
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2. Curative versus palliative treatments for recurrent hepatocellular carcinoma: a multicentric weighted comparison

Author

Ciulli, Cristina, Giani, Alessandro, Carissimi, Francesca, Costa, Guido, Ratti, Francesca, Cucchetti, Alessandro, Calabrese, Francesco, Cremaschi, Elena, Lazzari, Giovanni, Franceschi, Angelo, Sega, Valentina, Conticchio, Maria, Pennacchi, Luca, Ciola, Michele, Sciannamea, Ivano, De Peppo, Valerio, Famularo, Simone, Donadon, Matteo, Cipriani, Federica, Bernasconi, Davide P., LaBarba, Giuliano, Dominioni, Tommaso, Iaria, Maurizio, Molfino, Sarah, Conci, Simone, Ferrari, Cecilia, Garatti, Marco, Delvecchio, Antonella, Troci, Albert, Patauner, Stefan, Frassani, Silvia, Cosimelli, Maurizio, Zanus, Giacomo, Giuliante, Felice, Jovine, Elio, Valsecchi, Maria G., Grazi, GianLuca, Antonucci, Adelmo, Frena, Antonio, Crespi, Michele, Memeo, Riccardo, Zimmitti, Giuseppe, Griseri, Guido, Ruzzenente, Andrea, Baiocchi, Gianluca, DallaValle, Raffaele, Maestri, Marcello, Ercolani, Giorgio, Aldrighetti, Luca, Torzilli, Guido, and Romano, Fabrizio

Published
2021
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5. Hepatocellular carcinoma surgical and oncological trends in a national multicentric population: the HERCOLES experience

Author

Famularo, Simone, Donadon, Matteo, Cipriani, Federica, Ardito, Francesco, Carissimi, Francesca, Perri, Pasquale, Iaria, Maurizio, Dominioni, Tommaso, Zanello, Matteo, Conci, Simone, Molfino, Sarah, LaBarba, Giuliano, Ferrari, Cecilia, Germani, Paola, Patauner, Stefan, Pinotti, Enrico, Lodo, Enrico, Garatti, Marco, Sciannamea, Ivano, Troci, Albert, Conticchio, Maria, Floridi, Antonio, Chiarelli, Marco, Fumagalli, Luca, Memeo, Riccardo, Crespi, Michele, Antonucci, Adelmo, Zimmitti, Giuseppe, Zanus, Giacomo, Zago, Mauro, Frena, Antonio, Tarchi, Paola, Griseri, Guido, Ercolani, Giorgio, Baiocchi, Gian Luca, Ruzzenente, Andrea, Jovine, Elio, Maestri, Marcello, DallaValle, Raffaele, Grazi, Gian Luca, Giuliante, Felice, Aldrighetti, Luca, Torzilli, Guido, and Romano, Fabrizio

Published
2020
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8. Hepatocellular carcinoma surgical and oncological trends in a national multicentric population: the HERCOLES experience

Author

Famularo, Simone, Donadon, Matteo, Cipriani, Federica, Ardito, Francesco, Carissimi, Francesca, Perri, Pasquale, Iaria, Maurizio, Dominioni, Tommaso, Zanello, Matteo, Conci, Simone, Molfino, Sarah, LaBarba, Giuliano, Ferrari, Cecilia, Germani, Paola, Patauner, Stefan, Pinotti, Enrico, Lodo, Enrico, Garatti, Marco, Sciannamea, Ivano, Troci, Albert, Conticchio, Maria, Floridi, Antonio, Chiarelli, Marco, Fumagalli, Luca, Memeo, Riccardo, Crespi, Michele, Antonucci, Adelmo, Zimmitti, Giuseppe, Zanus, Giacomo, Zago, Mauro, Frena, Antonio, Tarchi, Paola, Griseri, Guido, Ercolani, Giorgio, Baiocchi, Gian Luca, Ruzzenente, Andrea, Jovine, Elio, Maestri, Marcello, DallaValle, Raffaele, Grazi, Gian Luca, Giuliante, Felice, Aldrighetti, Luca, Torzilli, Guido, and Romano, Fabrizio

Abstract

Liver surgery is the first line treatment for hepatocarcinoma. Hepatocarcinoma Recurrence on the Liver Study (HERCOLES) Group was established in 2018 with the goal to create a network of Italian centres sharing data and promoting scientific research on hepatocellular carcinoma (HCC) in the surgical field. This is the first national report that analyses the trends in surgical and oncological outcomes. Register data were collected by 22 Italian centres between 2008 and 2018. One hundred sixty-four variables were collected, regarding liver functional status, tumour burden, radiological, intraoperative and perioperative data, histological features and oncological follow-up. 2381 Patients were enrolled. Median age was 70 (IQR 63–75) years old. Cirrhosis was present in 1491 patients (62.6%), and Child-A were 89.9% of cases. HCC was staged as BCLC0-A in almost 50% of cases, while BCLC B and C were 20.7% and 17.9% respectively. Major liver resections were 481 (20.2%), and laparoscopy was employed in 753 (31.6%) cases. Severe complications occurred only in 5%. Postoperative ascites was recorded in 10.5% of patients, while posthepatectomy liver failure was observed in 4.9%. Ninety-day mortality was 2.5%. At 5 years, overall survival was 66.1% and disease-free survival was 40.9%. Recurrence was intrahepatic in 74.6% of cases. Redo-surgery and thermoablation for recurrence were performed up to 32% of cases. This is the most updated Italian report of the national experience in surgical treatment for HCC. This dataset is consistently allowing the participating centres in creating multicentric analysis which are already running with a very large sample size and strong power.

Published
2024
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9. Injury patterns and causes of death in 953 patients with penetrating abdominal war wounds in a civilian independent non-governmental organization hospital in Lashkargah, Afghanistan

Author

Cardi, Maurizio, Ibrahim, Khushal, Alizai, Shah Wali, Mohammad, Hamayoun, Garatti, Marco, Rainone, Antonio, Di Marzo, Francesco, La Torre, Giuseppe, Paschetto, Michela, Carbonari, Ludovica, Mingarelli, Valentina, Mingoli, Andrea, Sica, Giuseppe S., and Sibio, Simone

Published
2019
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14. Ileocolic invagination in adults: A totally minimally invasive endoscopic and laparoscopic staged approach

Author

Treppiedi, Elio, Cocchi, Lorenzo, Zimmitti, Giuseppe, Manzoni, Alberto, Seletti, Valeria, Bizzotto, Alessandra, Spada, Cristiano, Garatti, Marco, and Rosso, Edoardo

Subjects
Laparoscopy, Adults, Surgery, Intussusception, CAT scans, Diagnostic imaging, Tomography, Intestinal obstruction, Health
Abstract

Byline: Elio. Treppiedi, Lorenzo. Cocchi, Giuseppe. Zimmitti, Alberto. Manzoni, Valeria. Seletti, Alessandra. Bizzotto, Cristiano. Spada, Marco. Garatti, Edoardo. Rosso Adult intussusception of the bowel is a rare clinical entity, and [...]

Published
2020

16. The Impact of Alias Analysis on VLIW Scheduling

Author

Garatti, Marco, Costa, Roberto, Reghizzi, Stefano Crespi, Rohou, Erven, Goos, G., editor, Hartmanis, J., editor, van Leeuwen, J., editor, Zima, Hans P., editor, Joe, Kazuki, editor, Sato, Mitsuhisa, editor, Seo, Yoshiki, editor, and Shimasaki, Masaaki, editor

Published
2002
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17. Management of portal annular pancreas during laparoscopic pancreaticoduodenectomy

Author

Zimmitti, Giuseppe, Manzoni, Alberto, Ramera, Marco, Villanacci, Alberta, Sega, Valentina, Treppiedi, Elio, Guerini, Francesca, Garatti, Marco, Codignola, Claudio, and Rosso, Edoardo

Subjects
Pancreatic cancer -- Diagnosis -- Case studies, Pancreaticoduodenectomy -- Usage, Health
Abstract

Byline: Giuseppe. Zimmitti, Alberto. Manzoni, Marco. Ramera, Alberta. Villanacci, Valentina. Sega, Elio. Treppiedi, Francesca. Guerini, Marco. Garatti, Claudio. Codignola, Edoardo. Rosso Portal annular pancreas (PAP) is a pancreatic congenital anomaly [...]

Published
2018

18. The Impact of Postoperative Ascites on Survival After Surgery for Hepatocellular Carcinoma: a National Study

Author

Famularo, Simone, primary, Donadon, Matteo, additional, Cipriani, Federica, additional, Ardito, Francesco, additional, Iaria, Maurizio, additional, Carissimi, Francesca, additional, Perri, Pasquale, additional, Dominioni, Tommaso, additional, Zanello, Matteo, additional, Conci, Simone, additional, Molfino, Sarah, additional, D’Acapito, Fabrizio, additional, Germani, Paola, additional, Ferrari, Cecilia, additional, Patauner, Stefan, additional, Pinotti, Enrico, additional, Sciannamea, Ivano, additional, Garatti, Marco, additional, Lodo, Enrico, additional, Troci, Albert, additional, Delvecchio, Antonella, additional, Floridi, Antonio, additional, Bernasconi, Davide Paolo, additional, Fumagalli, Luca, additional, Chiarelli, Marco, additional, Memeo, Riccardo, additional, Crespi, Michele, additional, Zanus, Giacomo, additional, Zimmitti, Giuseppe, additional, Antonucci, Adelmo, additional, Zago, Mauro, additional, Frena, Antonio, additional, Griseri, Guido, additional, Tarchi, Paola, additional, Ercolani, Giorgio, additional, Baiocchi, Gian Luca, additional, Ruzzenente, Andrea, additional, Jovine, Elio, additional, Maestri, Marcello, additional, Grazi, GianLuca, additional, Valle, Raffaele Dalla, additional, Giuliante, Felice, additional, Aldrighetti, Luca, additional, Romano, Fabrizio, additional, Torzilli, Guido, additional, Costa, Guido, additional, Ciulli, Cristina, additional, Giani, Alessandro, additional, Ratti, Francesca, additional, Bellobono, Manuela, additional, Cremaschi, Elena, additional, Valsecchi, Maria Grazia, additional, De Peppo, Valerio, additional, Calabrese, Francesco, additional, DeSario, Giuseppina, additional, Lazzari, Giovanni, additional, Cucchetti, Alessandro, additional, Cosola, Davide, additional, Percivale, Andrea, additional, Ciola, Michele, additional, Montuori, Mauro, additional, Frassani, Silvia, additional, Manzoni, Alberto, additional, Salvador, Luca, additional, Pennacchi, Luca, additional, Corleone, Pio, additional, and Conticchio, Maria, additional

Published
2021
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19. Curative versus palliative treatments for recurrent hepatocellular carcinoma: a multicentric weighted comparison

Author

Famularo, Simone, primary, Donadon, Matteo, additional, Cipriani, Federica, additional, Bernasconi, Davide P., additional, LaBarba, Giuliano, additional, Dominioni, Tommaso, additional, Iaria, Maurizio, additional, Molfino, Sarah, additional, Conci, Simone, additional, Ferrari, Cecilia, additional, Garatti, Marco, additional, Delvecchio, Antonella, additional, Troci, Albert, additional, Patauner, Stefan, additional, Frassani, Silvia, additional, Cosimelli, Maurizio, additional, Zanus, Giacomo, additional, Giuliante, Felice, additional, Jovine, Elio, additional, Valsecchi, Maria G., additional, Grazi, GianLuca, additional, Antonucci, Adelmo, additional, Frena, Antonio, additional, Crespi, Michele, additional, Memeo, Riccardo, additional, Zimmitti, Giuseppe, additional, Griseri, Guido, additional, Ruzzenente, Andrea, additional, Baiocchi, Gianluca, additional, DallaValle, Raffaele, additional, Maestri, Marcello, additional, Ercolani, Giorgio, additional, Aldrighetti, Luca, additional, Torzilli, Guido, additional, Romano, Fabrizio, additional, Ciulli, Cristina, additional, Giani, Alessandro, additional, Carissimi, Francesca, additional, Costa, Guido, additional, Ratti, Francesca, additional, Cucchetti, Alessandro, additional, Calabrese, Francesco, additional, Cremaschi, Elena, additional, Lazzari, Giovanni, additional, Franceschi, Angelo, additional, Sega, Valentina, additional, Conticchio, Maria, additional, Pennacchi, Luca, additional, Ciola, Michele, additional, Sciannamea, Ivano, additional, and De Peppo, Valerio, additional

Published
2021
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20. From PVE to HVE to fully laparoscopic rescue ALPPS: a case report of multidisciplinary management of giant HCC

Author

Malerba, Valentina, primary, Benedetti Cacciaguerra, Andrea, additional, Zimmitti, Giuseppe, additional, Manzoni, Alberto, additional, Sallemi, Claudio, additional, Monfardini, Lorenzo, additional, Graffeo, Massimo, additional, Bnà, Claudio, additional, Natalini, Giuseppe, additional, Zaniboni, Alberto, additional, Montresor, Maria Cristina, additional, Codignola, Claudio, additional, Garatti, Marco, additional, and Abu Hilal, Mohammed, additional

Published
2021
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23. Investigation of intraoperative factors associated with postoperative pancreatic fistula following laparoscopic left pancreatectomy with stapled closure: a video review-based analysis

Author

Zimmitti, Giuseppe, primary, La Mendola, Roberta, additional, Manzoni, Alberto, additional, Sega, Valentina, additional, Malerba, Valentina, additional, Treppiedi, Elio, additional, Codignola, Claudio, additional, Monfardini, Lorenzo, additional, Garatti, Marco, additional, and Rosso, Edoardo, additional

Published
2020
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37. The Impact of Alias Analysis on VLIW Scheduling.

Author

Garatti, Marco, Costa, Roberto, Reghizzi, Stefano Crespi, and Rohou, Erven

Abstract

This experiment studies the speed-up increase that alias analysis (AA) produces on code for very long instruction word machines. AA is done on-demand when requested by the scheduler, in order to eliminate critical arcs of the data dependence graph. Different heuristic criteria are investigated for deciding when to compute alias information,and they show that only a fraction of the alias relation really contributes to the program speed-up. A qualitative study shows that the quality of the initial code affects the speedup alias analysis can give. The results should help compiler designers for VLIW machines in making cost effective AA decisions. [ABSTRACT FROM AUTHOR]

Published
2006
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39. Curative versus palliative treatments for recurrent hepatocellular carcinoma: a multicentric weighted comparison

Author

Simone Famularo, Matteo Donadon, Federica Cipriani, Davide P. Bernasconi, Giuliano LaBarba, Tommaso Dominioni, Maurizio Iaria, Sarah Molfino, Simone Conci, Cecilia Ferrari, Marco Garatti, Antonella Delvecchio, Albert Troci, Stefan Patauner, Silvia Frassani, Maurizio Cosimelli, Giacomo Zanus, Felice Giuliante, Elio Jovine, Maria G. Valsecchi, GianLuca Grazi, Adelmo Antonucci, Antonio Frena, Michele Crespi, Riccardo Memeo, Giuseppe Zimmitti, Guido Griseri, Andrea Ruzzenente, Gianluca Baiocchi, Raffaele DallaValle, Marcello Maestri, Giorgio Ercolani, Luca Aldrighetti, Guido Torzilli, Fabrizio Romano, Cristina Ciulli, Alessandro Giani, Francesca Carissimi, Guido Costa, Francesca Ratti, Alessandro Cucchetti, Francesco Calabrese, Elena Cremaschi, Giovanni Lazzari, Angelo Franceschi, Valentina Sega, Maria Conticchio, Luca Pennacchi, Michele Ciola, Ivano Sciannamea, Valerio De Peppo, Famularo S., Donadon M., Cipriani F., Bernasconi D.P., LaBarba G., Dominioni T., Iaria M., Molfino S., Conci S., Ferrari C., Garatti M., Delvecchio A., Troci A., Patauner S., Frassani S., Cosimelli M., Zanus G., Giuliante F., Jovine E., Valsecchi M.G., Grazi G., Antonucci A., Frena A., Crespi M., Memeo R., Zimmitti G., Griseri G., Ruzzenente A., Baiocchi G., DallaValle R., Maestri M., Ercolani G., Aldrighetti L., Torzilli G., Romano F., Ciulli C., Giani A., Carissimi F., Costa G., Ratti F., Cucchetti A., Calabrese F., Cremaschi E., Lazzari G., Franceschi A., Sega V., Conticchio M., Pennacchi L., Ciola M., Sciannamea I., De Peppo V., Famularo, Simone, Donadon, Matteo, Cipriani, Federica, Bernasconi, Davide P, Labarba, Giuliano, Dominioni, Tommaso, Iaria, Maurizio, Molfino, Sarah, Conci, Simone, Ferrari, Cecilia, Garatti, Marco, Delvecchio, Antonella, Troci, Albert, Patauner, Stefan, Frassani, Silvia, Cosimelli, Maurizio, Zanus, Giacomo, Giuliante, Felice, Jovine, Elio, Valsecchi, Maria G, Grazi, Gianluca, Antonucci, Adelmo, Frena, Antonio, Crespi, Michele, Memeo, Riccardo, Zimmitti, Giuseppe, Griseri, Guido, Ruzzenente, Andrea, Baiocchi, Gianluca, Dallavalle, Raffaele, Maestri, Marcello, Ercolani, Giorgio, Aldrighetti, Luca, Torzilli, Guido, and Romano, Fabrizio

Subjects
Sorafenib, medicine.medical_specialty, recurrence, Carcinoma, Hepatocellular, Tumor burden, 030230 surgery, liver, Gastroenterology, NO, 03 medical and health sciences, 0302 clinical medicine, hepatectomy, Retrospective Studie, Internal medicine, Humans, Medicine, Chemoembolization, Therapeutic, Liver surgery, Retrospective Studies, LS7_4, Hepatology, business.industry, Palliative Care, Liver Neoplasms, hepatocellular carcinoma, medicine.disease, Recurrent Hepatocellular Carcinoma, multicentric, Treatment Outcome, Time to recurrence, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, Liver function, Neoplasm Recurrence, Local, business, medicine.drug, Human
Abstract

Background Management of recurrence after surgery for hepatocellular carcinoma (rHCC) is still a debate. The aim was to compare the Survival after Recurrence (SAR) of curative (surgery or thermoablation) versus palliative (TACE or Sorafenib) treatments for patients with rHCC. Methods This is a multicentric Italian study, which collected data between 2007 and 2018 from 16 centers. Selected patients were then divided according to treatment allocation in Curative (CUR) or Palliative (PAL) Group. Inverse Probability Weighting (IPW) was used to weight the groups. Results 1,560 patients were evaluated, of which 421 experienced recurrence and were then eligible: 156 in CUR group and 256 in PAL group. Tumor burden and liver function were weighted by IPW, and two pseudo-population were obtained (CUR = 397.5 and PAL = 415.38). SAR rates at 1, 3 and 5 years were respectively 98.3%, 76.7%, 63.8% for CUR and 91.7%, 64.2% and 48.9% for PAL (p = 0.007). Median DFS was 43 months (95%CI = 32-74) for CUR group, while it was 23 months (95%CI = 18-27) for PAL (p = 0.017). Being treated by palliative approach (HR = 1.75; 95%CI = 1.14–2.67; p = 0.01) and having a median size of the recurrent nodule>5 cm (HR = 1.875; 95%CI = 1.22–2.86; p = 0.004) were the only predictors of mortality after recurrence, while time to recurrence was the only protective factor (HR = 0.616; 95%CI = 0.54–0.69; p Conclusion Curative approaches may guarantee long-term survival in case of recurrence.

Published
2021

40. Hepatocellular carcinoma surgical and oncological trends in a national multicentric population: the HERCOLES experience

Author

Famularo, S., Donadon, M., Cipriani, Fabrizio, Ardito, Francesco, Carissimi, F., Perri, Pierluigi, Iaria, M., Dominioni, T., Zanello, M., Conci, S., Molfino, S., Labarba, G., Ferrari, C., Germani, P., Patauner, S., Pinotti, E., Lodo, E., Garatti, M., Sciannamea, I., Troci, A., Conticchio, M., Floridi, A., Chiarelli, M., Fumagalli, L., Memeo, R., Crespi, M., Antonucci, Anna Maria, Zimmitti, Giuseppe, Zanus, G., Zago, M., Frena, A., Tarchi, P., Griseri, G., Ercolani, G., Baiocchi, G. L., Ruzzenente, A., Jovine, E., Maestri, Marta, Dallavalle, R., Grazi, G. L., Giuliante, Felice, Aldrighetti, L., Torzilli, Guido, Romano, Federica, Bernasconi, D. P., Ciulli, C., Giani, A., Costa, G., Ratti, F., Bellobono, M., Calabrese, F., Cremaschi, E., De Peppo, V., Cucchetti, A., Lazzari, Giovanni, Percivale, A., Ciola, M., Sega, V., Frassani, S., Del Vecchio, Arianna, Pennacchi, L., Corleone, P., Cosola, D., Salvador, L., Montuori, M., Famularo, Simone, Donadon, Matteo, Cipriani, Federica, Ardito, Francesco, Carissimi, Francesca, Perri, Pasquale, Iaria, Maurizio, Dominioni, Tommaso, Zanello, Matteo, Conci, Simone, Molfino, Sarah, LaBarba, Giuliano, Ferrari, Cecilia, Germani, Paola, Patauner, Stefan, Pinotti, Enrico, Lodo, Enrico, Garatti, Marco, Sciannamea, Ivano, Troci, Albert, Conticchio, Maria, Floridi, Antonio, Chiarelli, Marco, Fumagalli, Luca, Memeo, Riccardo, Crespi, Michele, Antonucci, Adelmo, Zimmitti, Giuseppe, Zanus, Giacomo, Zago, Mauro, Frena, Antonio, Tarchi, Paola, Griseri, Guido, Ercolani, Giorgio, Baiocchi, Gian Luca, Ruzzenente, Andrea, Jovine, Elio, Maestri, Marcello, DallaValle, Raffaele, Grazi, Gian Luca, Giuliante, Felice, Aldrighetti, Luca, Torzilli, Guido, Romano, Fabrizio, Famularo, S., Donadon, M., Cipriani, F., Ardito, F., Carissimi, F., Perri, P., Iaria, M., Dominioni, T., Zanello, M., Conci, S., Molfino, S., Labarba, G., Ferrari, C., Germani, P., Patauner, S., Pinotti, E., Lodo, E., Garatti, M., Sciannamea, I., Troci, A., Conticchio, M., Floridi, A., Chiarelli, M., Fumagalli, L., Memeo, R., Crespi, M., Antonucci, A., Zimmitti, G., Zanus, G., Zago, M., Frena, A., Tarchi, P., Griseri, G., Ercolani, G., Baiocchi, G. L., Ruzzenente, A., Jovine, E., Maestri, M., Dallavalle, R., Grazi, G. L., Giuliante, F., Aldrighetti, L., Torzilli, G., Romano, F., Bernasconi, D. P., Ciulli, C., Giani, A., Costa, G., Ratti, F., Bellobono, M., Calabrese, F., Cremaschi, E., De Peppo, V., Cucchetti, A., Lazzari, G., Percivale, A., Ciola, M., Sega, V., Frassani, S., Del Vecchio, A., Pennacchi, L., Corleone, P., Cosola, D., Salvador, L., and Montuori, M.

Subjects
Male, Cirrhosis, Outcome Assessment, Hepatocellular carcinoma, Settore MED/18 - CHIRURGIA GENERALE, Datasets as Topic, HERCOLES, Hepatocarcinoma recurrence, Liver surgery, Redo surgery, Outcome Assessment, Health Care, Ascites, Registries, Laparoscopy, education.field_of_study, medicine.diagnostic_test, Liver Neoplasms, Middle Aged, Italy, Local, Radiological weapon, Female, medicine.symptom, Reoperation, medicine.medical_specialty, Carcinoma, Hepatocellular, Population, NO, Internal medicine, medicine, Hepatectomy, Humans, education, LS7_4, Aged, business.industry, Carcinoma, Hepatocellular, Perioperative, Hepatology, medicine.disease, Surgery, Health Care, Neoplasm Recurrence, Neoplasm Recurrence, Local, business
Abstract

Liver surgery is the first line treatment for hepatocarcinoma. Hepatocarcinoma Recurrence on the Liver Study (HERCOLES) Group was established in 2018 with the goal to create a network of Italian centres sharing data and promoting scientific research on hepatocellular carcinoma (HCC) in the surgical field. This is the first national report that analyses the trends in surgical and oncological outcomes. Register data were collected by 22 Italian centres between 2008 and 2018. One hundred sixty-four variables were collected, regarding liver functional status, tumour burden, radiological, intraoperative and perioperative data, histological features and oncological follow-up. 2381 Patients were enrolled. Median age was 70 (IQR 63-75) years old. Cirrhosis was present in 1491 patients (62.6%), and Child-A were 89.9% of cases. HCC was staged as BCLC0-A in almost 50% of cases, while BCLC B and C were 20.7% and 17.9% respectively. Major liver resections were 481 (20.2%), and laparoscopy was employed in 753 (31.6%) cases. Severe complications occurred only in 5%. Postoperative ascites was recorded in 10.5% of patients, while posthepatectomy liver failure was observed in 4.9%. Ninety-day mortality was 2.5%. At 5years, overall survival was 66.1% and disease-free survival was 40.9%. Recurrence was intrahepatic in 74.6% of cases. Redo-surgery and thermoablation for recurrence were performed up to 32% of cases. This is the most updated Italian report of the national experience in surgical treatment for HCC. This dataset is consistently allowing the participating centres in creating multicentric analysis which are already running with a very large sample size and strong power. Liver surgery is the first line treatment for hepatocarcinoma. Hepatocarcinoma Recurrence on the Liver Study (HERCOLES) Group was established in 2018 with the goal to create a network of Italian centres sharing data and promoting scientific research on hepatocellular carcinoma (HCC) in the surgical field. This is the first national report that analyses the trends in surgical and oncological outcomes. Register data were collected by 22 Italian centres between 2008 and 2018. One hundred sixty-four variables were collected, regarding liver functional status, tumour burden, radiological, intraoperative and perioperative data, histological features and oncological follow-up. 2381 Patients were enrolled. Median age was 70 (IQR 63–75) years old. Cirrhosis was present in 1491 patients (62.6%), and Child-A were 89.9% of cases. HCC was staged as BCLC0-A in almost 50% of cases, while BCLC B and C were 20.7% and 17.9% respectively. Major liver resections were 481 (20.2%), and laparoscopy was employed in 753 (31.6%) cases. Severe complications occurred only in 5%. Postoperative ascites was recorded in 10.5% of patients, while posthepatectomy liver failure was observed in 4.9%. Ninety-day mortality was 2.5%. At 5years, overall survival was 66.1% and disease-free survival was 40.9%. Recurrence was intrahepatic in 74.6% of cases. Redo-surgery and thermoablation for recurrence were performed up to 32% of cases. This is the most updated Italian report of the national experience in surgical treatment for HCC. This dataset is consistently allowing the participating centres in creating multicentric analysis which are already running with a very large sample size and strong power.

Published
2020

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