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8 results on '"García, F. Martínez"'

7. Investigation of the role of tyrosine kinase receptor EPHA3 in colorectal cancer

Author

Institut Català de la Salut, [Andretta E, Cartón-García F, Martínez-Barriocanal Á, de Marcondes PG, Jimenez-Flores LM, Macaya I, Bazzocco S, Bilic J, Rodrigues P, Nieto R] Grup de Recerca Biomèdica en Tumors Digestius, Vall d’Hebron Institut de Recerca, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. [Landolfi S, Ramon Y Cajal S] Servei de Patologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain. [Schwartz S] Grup de Direccionament i Alliberament Farmacològic, Vall d’Hebron Institut de Recerca, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Spain. [Dopeso H, Arango D] Grup de Recerca Biomèdica en Tumors Digestius, Vall d’Hebron Institut de Recerca, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain., and Hospital Universitari Vall d'Hebron

Subjects
Quinases, Mucosa intestinal, Otros calificadores::Otros calificadores::/genética [Otros calificadores], Còlon - Càncer, Digestive System Diseases::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Digestive System Diseases::Digestive System Diseases::Digestive System Diseases::Digestive System Diseases::Colorectal Neoplasms [DISEASES], Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Tyrosine Kinases::Receptor Protein-Tyrosine Kinases [CHEMICALS AND DRUGS], Other subheadings::Other subheadings::/genetics [Other subheadings], Sistema Digestivo::Tracto Gastrointestinal::Intestinos::Mucosa Intestinal [ANATOMÍA], Enzimas y Coenzimas::Enzimas::Transferasas::Fosfotransferasas::Fosfotransferasas (Aceptor de Grupo Alcohol)::Proteínas Quinasas::Proteínas Tirosina Quinasas::Proteínas Tirosina Quinasas Receptoras [COMPUESTOS QUÍMICOS Y DROGAS], Other subheadings::Other subheadings::/metabolism [Other subheadings], Enfermedades del Sistema Digestivo::Neoplasias del Sistema Digestivo::Neoplasias Gastrointestinales::Neoplasias Intestinales::Enfermedades del Sistema Digestivo::Enfermedades del Sistema Digestivo::Enfermedades del Sistema Digestivo::Enfermedades del Sistema Digestivo::Neoplasias Colorrectales [ENFERMEDADES], Digestive System::Gastrointestinal Tract::Intestines::Intestinal Mucosa [ANATOMY], Otros calificadores::Otros calificadores::/metabolismo [Otros calificadores]
Published
2021

8. Investigation of the role of tyrosine kinase receptor EPHA3 in colorectal cancer

Author

Andretta, Elena, Cartón-Garcia, Fernando, Martínez-Barriocanal, Águeda, de Marcondes, Priscila Guimarães, Jimenez-Flores, Lizbeth M., Macaya, Irati, Bazzocco, Sarah, Bilic Zimmermann, Josipa, Rodrigues, Paulo, Nieto Raya, Rocio, Landolfi, Stefania, Ramon y Cajal, Santiago, Schwartz, Simo, Brown, Arthur, Dopeso, Higinio, Arango, Diego, Universitat Autònoma de Barcelona, Institut Català de la Salut, [Andretta E, Cartón-García F, Martínez-Barriocanal Á, de Marcondes PG, Jimenez-Flores LM, Macaya I, Bazzocco S, Bilic J, Rodrigues P, Nieto R] Grup de Recerca Biomèdica en Tumors Digestius, Vall d’Hebron Institut de Recerca, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. [Landolfi S, Ramon Y Cajal S] Servei de Patologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain. [Schwartz S] Grup de Direccionament i Alliberament Farmacològic, Vall d’Hebron Institut de Recerca, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Spain. [Dopeso H, Arango D] Grup de Recerca Biomèdica en Tumors Digestius, Vall d’Hebron Institut de Recerca, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain., Hospital Universitari Vall d'Hebron, and Vall d'Hebron Barcelona Hospital Campus

Subjects
0301 basic medicine, Quinases, Colorectal cancer, Digestive System Diseases::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Digestive System Diseases::Digestive System Diseases::Digestive System Diseases::Digestive System Diseases::Colorectal Neoplasms [DISEASES], Gene Expression, Tumor initiation, Receptor tyrosine kinase, Mice, 0302 clinical medicine, Mucosa intestinal, Cell Movement, Còlon - Càncer, Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Tyrosine Kinases::Receptor Protein-Tyrosine Kinases [CHEMICALS AND DRUGS], Hospital Universitari Vall d’Hebron, Intestinal Mucosa, Neoplasm Metastasis, 61 - Medicina, Otros calificadores::Otros calificadores::/metabolismo [Otros calificadores], Mice, Knockout, Multidisciplinary, biology, Otros calificadores::Otros calificadores::/genética [Otros calificadores], Receptor, EphA3, Other subheadings::Other subheadings::/metabolism [Other subheadings], enzimas y coenzimas::enzimas::transferasas::fosfotransferasas::fosfotransferasas (grupo alcohol aceptor)::proteína cinasas::proteína-tirosina cinasas::receptores proteína-tirosina cinasas [COMPUESTOS QUÍMICOS Y DROGAS], Cell Transformation, Neoplastic, 030220 oncology & carcinogenesis, Sistema Digestivo::Tracto Gastrointestinal::Intestinos::Mucosa Intestinal [ANATOMÍA], Enzimas y Coenzimas::Enzimas::Transferasas::Fosfotransferasas::Fosfotransferasas (Aceptor de Grupo Alcohol)::Proteínas Quinasas::Proteínas Tirosina Quinasas::Proteínas Tirosina Quinasas Receptoras [COMPUESTOS QUÍMICOS Y DROGAS], Enfermedades del Sistema Digestivo::Neoplasias del Sistema Digestivo::Neoplasias Gastrointestinales::Neoplasias Intestinales::Enfermedades del Sistema Digestivo::Enfermedades del Sistema Digestivo::Enfermedades del Sistema Digestivo::Enfermedades del Sistema Digestivo::Neoplasias Colorrectales [ENFERMEDADES], Colorectal Neoplasms, Tyrosine kinase, Signal Transduction, Ciències multidisciplinàries, Genotype, Article, 03 medical and health sciences, Cell Line, Tumor, medicine, Other subheadings::Other subheadings::/genetics [Other subheadings], Animals, Humans, enfermedades del sistema digestivo::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias intestinales::enfermedades del sistema digestivo::enfermedades del sistema digestivo::enfermedades del sistema digestivo::enfermedades del sistema digestivo::neoplasias colorrectales [ENFERMEDADES], Digestive System::Gastrointestinal Tract::Intestines::Intestinal Mucosa [ANATOMY], Cell Proliferation, AXL receptor tyrosine kinase, Erythropoietin-producing hepatocellular (Eph) receptor, Cancer, Receptor Protein-Tyrosine Kinases, Vall d’Hebron Institut de Recerca (VHIR), medicine.disease, 030104 developmental biology, ROR1, Cancer research, biology.protein
Abstract

Tyrosine kinase; EPHA3; Colorectal cancer Tirosina-cinasa; EPHA3; Càncer colorectal Tirosina quinasa; EPHA3; Cáncer colorrectal EPH signaling deregulation has been shown to be important for colorectal carcinogenesis and genome-wide sequencing efforts have identified EPHA3 as one of the most frequently mutated genes in these tumors. However, the role of EPHA3 in colorectal cancer has not been thoroughly investigated. We show here that ectopic expression of wild type EPHA3 in colon cancer cells did not affect their growth, motility/invasion or metastatic potential in vivo. Moreover, overexpression of mutant EPHA3 or deletion of the endogenous mutant EPHA3 in colon cancer cells did not affect their growth or motility. EPHA3 inactivation in mice did not initiate the tumorigenic process in their intestine, and had no effects on tumor size/multiplicity after tumor initiation either genetically or pharmacologically. In addition, immunohistochemical analysis of EPHA3 tumor levels did not reveal associations with survival or clinicopathological features of colorectal cancer patients. In conclusion, we show that EPHA3 does not play a major role in colorectal tumorigenesis. These results significantly contribute to our understanding of the role of EPH signaling during colorectal carcinogenesis, and highlighting the need for detailed functional studies to confirm the relevance of putative cancer driver genes identified in sequencing efforts of the cancer genome.

Published
2015

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