Search

Your search keyword '"García‐Fiñana, Marta"' showing total 290 results
Start Over Author "García‐Fiñana, Marta"
290 results on '"García‐Fiñana, Marta"'

2. Can self-testing be enhanced to hasten safe return of healthcare workers in pandemics? Random order, open label trial using two manufacturers’ SARS-CoV-2 lateral flow devices concurrently

Author

Zhang, Xingna, primary, Cheyne, Christopher, additional, Jones, Christopher, additional, Humann, Michael, additional, Leeming, Gary, additional, Smith, Claire, additional, Hughes, David, additional, Burnside, Girvan, additional, Dodd, Susanna, additional, Prentice-Randal, Rebekah, additional, Dong, Xiaofeng, additional, Semple, Malcolm, additional, Neal, Timothy, additional, Tunkel, Sarah, additional, Fowler, Tom, additional, Turtle, Lance, additional, García-Fiñana, Marta, additional, and Buchan, Iain, additional

Published
2024
Full Text
View/download PDF

3. The use of parent‐completed questionnaires to investigate developmental outcomes in large populations of children exposed to antiseizure medications in pregnancy

Author

Bluett‐Duncan, Matthew, primary, Bullen, Philip, additional, Campbell, Ellen, additional, Clayton‐Smith, Jill, additional, Craig, John, additional, García‐Fiñana, Marta, additional, Hughes, David M., additional, Ingham, Amy, additional, Irwin, Beth, additional, Jackson, Cerian, additional, Kelly, Teresa, additional, Morrow, James, additional, Rushton, Sarah, additional, Winterbottom, Janine, additional, Wood, Amanda G., additional, Yates, Laura M., additional, and Bromley, Rebecca L., additional

Published
2024
Full Text
View/download PDF

6. Gas Chromatography–Sensor System Aids Diagnosis of Inflammatory Bowel Disease, and Separates Crohn's from Ulcerative Colitis, in Children.

Author

Slater, Rachael, Tharmaratnam, Kukatharmini, Belnour, Salma, Auth, Marcus Karl-Heinz, Muhammed, Rafeeq, Spray, Christine, Wang, Duolao, de Lacy Costello, Ben, García-Fiñana, Marta, Allen, Stephen, and Probert, Chris

Subjects
CROHN'S disease, ULCERATIVE colitis, INFLAMMATORY bowel diseases, VOLATILE organic compounds, CALPROTECTIN, PEDIATRICS
Abstract

The diagnosis of inflammatory bowel disease (IBD) in children and the need to distinguish between subtypes (Crohn's disease (CD) and ulcerative colitis (UC)) requires lengthy investigative and invasive procedures. Non-invasive, rapid, and cost-effective tests to support these diagnoses are needed. Faecal volatile organic compounds (VOCs) are distinctive in IBD. VOC profiles can be rapidly determined using a gas chromatography–sensor device (OdoReader©). In an inception-cohort of children presenting with suspected IBD, we directly compared the diagnostic fidelity of faecal calprotectin (FCP, a non-specific protein marker of intestinal inflammation) with OdoReader© VOC profiles of children subsequently diagnosed with IBD with matched controls diagnosed with other gastrointestinal conditions. The OdoReader© was 82% (95% confidence interval 75–89%) sensitive and 71% (61–80%) specific but did not outperform FCP (sensitivity 93% (77–99%) and specificity 86% (67–96%); 250 µg/g FCP cut off) in the diagnosis of IBD from other gastrointestinal conditions when validated in a separate sample from the same cohort. However, unlike FCP and better than other similar technologies, the OdoReader© could distinguish paediatric CD from UC (up to 88% (82–93%) sensitivity and 80% (71–89%) specificity in the validation set) and justifies further validation in larger studies. A non-invasive test based on VOCs could help streamline and limit invasive investigations in children. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

8. Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK

Author

Baillie, J Kenneth, Semple, Malcolm G, Openshaw, Peter JM, Carson, Gail, Alex, Beatrice, Bach, Benjamin, Barclay, Wendy S, Bogaert, Debby, Chand, Meera, Cooke, Graham S, Docherty, Annemarie B, Dunning, Jake, da Silva Filipe, Ana, Fletcher, Tom, Green, Christopher A, Harrison, Ewen M, Hiscox, Julian A, Ho, Antonia YW, Horby, Peter W, Ijaz, Samreen, Khoo, Say, Klenerman, Paul, Law, Andrew, Lim, Wei Shen, Mentzer, Alexander J, Merson, Laura, Meynert, Alison M, Noursadeghi, Mahdad, Moore, Shona C, Palmarini, Massimo, Paxton, William A, Pollakis, Georgios, Price, Nicholas, Rambaut, Andrew, Robertson, David L, Russell, Clark D, Sancho-Shimizu, Vanessa, Scott, Janet T, de Silva, Thushan, Sigfrid, Louise, Solomon, Tom, Sriskandan, Shiranee, Stuart, David, Summers, Charlotte, Tedder, Richard S, Thomson, Emma C, Thompson, AA Roger, Thwaites, Ryan S, Turtle, Lance CW, Gupta, Rishi K, Palmieri, Carlo, Zambon, Maria, Hardwick, Hayley, Donohue, Chloe, Lyons, Ruth, Griffiths, Fiona, Oosthuyzen, Wilna, Norman, Lisa, Pius, Riinu, Drake, Thomas M, Fairfield, Cameron J, Knight, Stephen R, Mclean, Kenneth A, Murphy, Derek, Shaw, Catherine A, Dalton, Jo, Girvan, Michelle, Saviciute, Egle, Roberts, Stephanie, Harrison, Janet, Marsh, Laura, Connor, Marie, Halpin, Sophie, Jackson, Clare, Gamble, Carrol, Leeming, Gary, Wham, Murray, Clohisey, Sara, Hendry, Ross, Scott-Brown, James, Greenhalf, William, Shaw, Victoria, McDonald, Sarah E, Keating, Seán, Ahmed, Katie A, Armstrong, Jane A, Ashworth, Milton, Asiimwe, Innocent G, Bakshi, Siddharth, Barlow, Samantha L, Booth, Laura, Brennan, Benjamin, Bullock, Katie, Catterall, Benjamin WA, Clark, Jordan J, Clarke, Emily A, Cole, Sarah, Cooper, Louise, Cox, Helen, Davis, Christopher, Dincarslan, Oslem, Dunn, Chris, Dyer, Philip, Elliott, Angela, Evans, Anthony, Finch, Lorna, Fisher, Lewis WS, Foster, Terry, Garcia-Dorival, Isabel, Gunning, Philip, Hartley, Catherine, Jensen, Rebecca L, Jones, Christopher B, Jones, Trevor R, Khandaker, Shadia, King, Katharine, Kiy, Robyn T, Koukorava, Chrysa, Lake, Annette, Lant, Suzannah, Latawiec, Diane, Lavelle-Langham, Lara, Lefteri, Daniella, Lett, Lauren, Livoti, Lucia A, Mancini, Maria, McDonald, Sarah, McEvoy, Laurence, McLauchlan, John, Metelmann, Soeren, Miah, Nahida S, Middleton, Joanna, Mitchell, Joyce, Murphy, Ellen G, Penrice-Randal, Rebekah, Pilgrim, Jack, Prince, Tessa, Reynolds, Will, Ridley, P. Matthew, Sales, Debby, Shaw, Victoria E, Shears, Rebecca K, Small, Benjamin, Subramaniam, Krishanthi S, Szemiel, Agnieska, Taggart, Aislynn, Tanianis-Hughes, Jolanta, Thomas, Jordan, Trochu, Erwan, van Tonder, Libby, Wilcock, Eve, Zhang, J. Eunice, Flaherty, Lisa, Maziere, Nicole, Cass, Emily, Doce Carracedo, Alejandra, Carlucci, Nicola, Holmes, Anthony, Massey, Hannah, Murphy, Lee, Wrobel, Nicola, McCafferty, Sarah, Morrice, Kirstie, MacLean, Alan, Adeniji, Kayode, Agranoff, Daniel, Agwuh, Ken, Ail, Dhiraj, Aldera, Erin L, Alegria, Ana, Angus, Brian, Ashish, Abdul, Atkinson, Dougal, Bari, Shahedal, Barlow, Gavin, Barnass, Stella, Barrett, Nicholas, Bassford, Christopher, Basude, Sneha, Baxter, David, Beadsworth, Michael, Bernatoniene, Jolanta, Berridge, John, Best, Nicola, Bothma, Pieter, Chadwick, David, Brittain-Long, Robin, Bulteel, Naomi, Burden, Tom, Burtenshaw, Andrew, Caruth, Vikki, Chambler, Duncan, Chee, Nigel, Child, Jenny, Chukkambotla, Srikanth, Clark, Tom, Collini, Paul, Cosgrove, Catherine, Cupitt, Jason, Cutino-Moguel, Maria-Teresa, Dark, Paul, Dawson, Chris, Dervisevic, Samir, Donnison, Phil, Douthwaite, Sam, DuRand, Ingrid, Dushianthan, Ahilanadan, Dyer, Tristan, Evans, Cariad, Eziefula, Chi, Fegan, Chrisopher, Finn, Adam, Fullerton, Duncan, Garg, Sanjeev, Garg, Atul, Gkrania-Klotsas, Effrossyni, Godden, Jo, Goldsmith, Arthur, Graham, Clive, Hardy, Elaine, Hartshorn, Stuart, Harvey, Daniel, Havalda, Peter, Hawcutt, Daniel B, Hobrok, Maria, Hodgson, Luke, Hormis, Anil, Jacobs, Michael, Jain, Susan, Jennings, Paul, Kaliappan, Agilan, Kasipandian, Vidya, Kegg, Stephen, Kelsey, Michael, Kendall, Jason, Kerrison, Caroline, Kerslake, Ian, Koch, Oliver, Koduri, Gouri, Koshy, George, Laha, Shondipon, Laird, Steven, Larkin, Susan, Leiner, Tamas, Lillie, Patrick, Limb, James, Linnett, Vanessa, Little, Jeff, Lyttle, Mark, MacMahon, Michael, MacNaughton, Emily, Mankregod, Ravish, Masson, Huw, Matovu, Elijah, McCullough, Katherine, McEwen, Ruth, Meda, Manjula, Mills, Gary, Minton, Jane, Mirfenderesky, Mariyam, Mohandas, Kavya, Mok, Quen, Moon, James, Moore, Elinoor, Morgan, Patrick, Morris, Craig, Mortimore, Katherine, Moses, Samuel, Mpenge, Mbiye, Mulla, Rohinton, Murphy, Michael, Nagel, Megan, Nagarajan, Thapas, Nelson, Mark, O'Shea, Matthew K, Otahal, Igor, Ostermann, Marlies, Pais, Mark, Panchatsharam, Selva, Papakonstantinou, Danai, Paraiso, Hassan, Patel, Brij, Pattison, Natalie, Pepperell, Justin, Peters, Mark, Phull, Mandeep, Pintus, Stefania, Singh Pooni, Jagtur, Post, Frank, Price, David, Prout, Rachel, Rae, Nikolas, Reschreiter, Henrik, Reynolds, Tim, Richardson, Neil, Roberts, Mark, Roberts, Devender, Rose, Alistair, Rousseau, Guy, Ryan, Brendan, Saluja, Taranprit, Shah, Aarti, Shanmuga, Prad, Sharma, Anil, Shawcross, Anna, Sizer, Jeremy, Shankar-Hari, Manu, Smith, Richard, Snelson, Catherine, Spittle, Nick, Staines, Nikki, Stambach, Tom, Stewart, Richard, Subudhi, Pradeep, Szakmany, Tamas, Tatham, Kate, Thomas, Jo, Thompson, Chris, Thompson, Robert, Tridente, Ascanio, Tupper-Carey, Darell, Twagira, Mary, Ustianowski, Andrew, Vallotton, Nick, Vincent-Smith, Lisa, Visuvanathan, Shico, Vuylsteke, Alan, Waddy, Sam, Wake, Rachel, Walden, Andrew, Welters, Ingeborg, Whitehouse, Tony, Whittaker, Paul, Whittington, Ashley, Papineni, Padmasayee, Wijesinghe, Meme, Williams, Martin, Wilson, Lawrence, Sarah, Sarah, Winchester, Stephen, Wiselka, Martin, Wolverson, Adam, Wooton, Daniel G, Workman, Andrew, Yates, Bryan, Young, Peter, Mulholland, Rachel H, Lone, Nazir I, Cheyne, Christopher P, De Angelis, Daniela, Diaz-Ordaz, Karla, Donegan, Cara, Funk, Sebastian, García-Fiñana, Marta, Hardwick, Hayley E, Ho, Antonia, Hughes, David M, Keogh, Ruth H, Kirwan, Peter D, Nguyen Van-Tam, Jonathan S, Spencer, Rebecca G, Tom, Brian DM, and Turtle, Lance

Published
2021
Full Text
View/download PDF

9. Individualised variable-interval risk-based screening in diabetic retinopathy: the ISDR research programme including RCT

Author

Harding, Simon, primary, Alshukri, Ayesh, additional, Appelbe, Duncan, additional, Broadbent, Deborah, additional, Burgess, Philip, additional, Byrne, Paula, additional, Cheyne, Christopher, additional, Eleuteri, Antonio, additional, Fisher, Anthony, additional, García-Fiñana, Marta, additional, Gabbay, Mark, additional, James, Marilyn, additional, Lathe, James, additional, Moitt, Tracy, additional, Rahni, Mehrdad Mobayen, additional, Roberts, John, additional, Sampson, Christopher, additional, Seddon, Daniel, additional, Stratton, Irene, additional, Thetford, Clare, additional, Vazquez-Arango, Pilar, additional, Vora, Jiten, additional, Wang, Amu, additional, and Williamson, Paula, additional

Published
2023
Full Text
View/download PDF

13. 3-D Volume of Interest Based Image Classification

Author

Udomchaiporn, Akadej, Coenen, Frans, García-Fiñana, Marta, Sluming, Vanessa, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Booth, Richard, editor, and Zhang, Min-Ling, editor

Published
2016
Full Text
View/download PDF

17. sj-pdf-3-jrs-10.1177_01410768231182389 - Supplemental material for COVID-19 risk mitigation in reopening mass cultural events: population-based observational study for the UK Events Research Programme in Liverpool City Region

Author

Burnside, Girvan, Cheyne, Christopher P, Leeming, Gary, Humann, Michael, Darby, Alistair, Green, Mark A, Crozier, Alexander, Maskell, Simon, O’Halloran, Kay, Musi, Elena, Carmi, Elinor, Khan, Naila, Fisher, Debra, Corcoran, Rhiannon, Dunning, Jake, Edmunds, W John, Tharmaratnam, Kukatharmini, Hughes, David M, Malki-Epshtein, Liora, Cook, Malcolm, Roberts, Ben M, Gallagher, Eileen, Howell, Kate, Chand, Meera, Kemp, Robin, Boulter, Matthew, Fowler, Tom, Semple, Malcolm G, Coffey, Emer, Ashton, Matt, García-Fiñana, Marta, and Buchan, Iain E

Subjects
Medicine
Abstract

Supplemental material, sj-pdf-3-jrs-10.1177_01410768231182389 for COVID-19 risk mitigation in reopening mass cultural events: population-based observational study for the UK Events Research Programme in Liverpool City Region by Girvan Burnside, Christopher P Cheyne, Gary Leeming, Michael Humann, Alistair Darby, Mark A Green, Alexander Crozier, Simon Maskell, Kay O’Halloran, Elena Musi, Elinor Carmi, Naila Khan, Debra Fisher, Rhiannon Corcoran, Jake Dunning, W John Edmunds, Kukatharmini Tharmaratnam, David M Hughes, Liora Malki-Epshtein, Malcolm Cook, Ben M Roberts, Eileen Gallagher, Kate Howell, Meera Chand, Robin Kemp, Matthew Boulter, Tom Fowler, Malcolm G Semple, Emer Coffey, Matt Ashton, The COVID-19 Genomics UK (COG-UK) Consortium, Marta García-Fiñana and Iain E Buchan in Journal of the Royal Society of Medicine

Published
2023
Full Text
View/download PDF

18. sj-pdf-4-jrs-10.1177_01410768231182389 - Supplemental material for COVID-19 risk mitigation in reopening mass cultural events: population-based observational study for the UK Events Research Programme in Liverpool City Region

Author

Burnside, Girvan, Cheyne, Christopher P, Leeming, Gary, Humann, Michael, Darby, Alistair, Green, Mark A, Crozier, Alexander, Maskell, Simon, O’Halloran, Kay, Musi, Elena, Carmi, Elinor, Khan, Naila, Fisher, Debra, Corcoran, Rhiannon, Dunning, Jake, Edmunds, W John, Tharmaratnam, Kukatharmini, Hughes, David M, Malki-Epshtein, Liora, Cook, Malcolm, Roberts, Ben M, Gallagher, Eileen, Howell, Kate, Chand, Meera, Kemp, Robin, Boulter, Matthew, Fowler, Tom, Semple, Malcolm G, Coffey, Emer, Ashton, Matt, García-Fiñana, Marta, and Buchan, Iain E

Subjects
Medicine
Abstract

Supplemental material, sj-pdf-4-jrs-10.1177_01410768231182389 for COVID-19 risk mitigation in reopening mass cultural events: population-based observational study for the UK Events Research Programme in Liverpool City Region by Girvan Burnside, Christopher P Cheyne, Gary Leeming, Michael Humann, Alistair Darby, Mark A Green, Alexander Crozier, Simon Maskell, Kay O’Halloran, Elena Musi, Elinor Carmi, Naila Khan, Debra Fisher, Rhiannon Corcoran, Jake Dunning, W John Edmunds, Kukatharmini Tharmaratnam, David M Hughes, Liora Malki-Epshtein, Malcolm Cook, Ben M Roberts, Eileen Gallagher, Kate Howell, Meera Chand, Robin Kemp, Matthew Boulter, Tom Fowler, Malcolm G Semple, Emer Coffey, Matt Ashton, The COVID-19 Genomics UK (COG-UK) Consortium, Marta García-Fiñana and Iain E Buchan in Journal of the Royal Society of Medicine

Published
2023
Full Text
View/download PDF

19. sj-pdf-2-jrs-10.1177_01410768231182389 - Supplemental material for COVID-19 risk mitigation in reopening mass cultural events: population-based observational study for the UK Events Research Programme in Liverpool City Region

Author

Burnside, Girvan, Cheyne, Christopher P, Leeming, Gary, Humann, Michael, Darby, Alistair, Green, Mark A, Crozier, Alexander, Maskell, Simon, O’Halloran, Kay, Musi, Elena, Carmi, Elinor, Khan, Naila, Fisher, Debra, Corcoran, Rhiannon, Dunning, Jake, Edmunds, W John, Tharmaratnam, Kukatharmini, Hughes, David M, Malki-Epshtein, Liora, Cook, Malcolm, Roberts, Ben M, Gallagher, Eileen, Howell, Kate, Chand, Meera, Kemp, Robin, Boulter, Matthew, Fowler, Tom, Semple, Malcolm G, Coffey, Emer, Ashton, Matt, García-Fiñana, Marta, and Buchan, Iain E

Subjects
Medicine
Abstract

Supplemental material, sj-pdf-2-jrs-10.1177_01410768231182389 for COVID-19 risk mitigation in reopening mass cultural events: population-based observational study for the UK Events Research Programme in Liverpool City Region by Girvan Burnside, Christopher P Cheyne, Gary Leeming, Michael Humann, Alistair Darby, Mark A Green, Alexander Crozier, Simon Maskell, Kay O’Halloran, Elena Musi, Elinor Carmi, Naila Khan, Debra Fisher, Rhiannon Corcoran, Jake Dunning, W John Edmunds, Kukatharmini Tharmaratnam, David M Hughes, Liora Malki-Epshtein, Malcolm Cook, Ben M Roberts, Eileen Gallagher, Kate Howell, Meera Chand, Robin Kemp, Matthew Boulter, Tom Fowler, Malcolm G Semple, Emer Coffey, Matt Ashton, The COVID-19 Genomics UK (COG-UK) Consortium, Marta García-Fiñana and Iain E Buchan in Journal of the Royal Society of Medicine

Published
2023
Full Text
View/download PDF

20. sj-pdf-6-jrs-10.1177_01410768231182389 - Supplemental material for COVID-19 risk mitigation in reopening mass cultural events: population-based observational study for the UK Events Research Programme in Liverpool City Region

Author

Burnside, Girvan, Cheyne, Christopher P, Leeming, Gary, Humann, Michael, Darby, Alistair, Green, Mark A, Crozier, Alexander, Maskell, Simon, O’Halloran, Kay, Musi, Elena, Carmi, Elinor, Khan, Naila, Fisher, Debra, Corcoran, Rhiannon, Dunning, Jake, Edmunds, W John, Tharmaratnam, Kukatharmini, Hughes, David M, Malki-Epshtein, Liora, Cook, Malcolm, Roberts, Ben M, Gallagher, Eileen, Howell, Kate, Chand, Meera, Kemp, Robin, Boulter, Matthew, Fowler, Tom, Semple, Malcolm G, Coffey, Emer, Ashton, Matt, García-Fiñana, Marta, and Buchan, Iain E

Subjects
Medicine
Abstract

Supplemental material, sj-pdf-6-jrs-10.1177_01410768231182389 for COVID-19 risk mitigation in reopening mass cultural events: population-based observational study for the UK Events Research Programme in Liverpool City Region by Girvan Burnside, Christopher P Cheyne, Gary Leeming, Michael Humann, Alistair Darby, Mark A Green, Alexander Crozier, Simon Maskell, Kay O’Halloran, Elena Musi, Elinor Carmi, Naila Khan, Debra Fisher, Rhiannon Corcoran, Jake Dunning, W John Edmunds, Kukatharmini Tharmaratnam, David M Hughes, Liora Malki-Epshtein, Malcolm Cook, Ben M Roberts, Eileen Gallagher, Kate Howell, Meera Chand, Robin Kemp, Matthew Boulter, Tom Fowler, Malcolm G Semple, Emer Coffey, Matt Ashton, The COVID-19 Genomics UK (COG-UK) ConsortiumMarta García-Fiñana and Iain E Buchan in Journal of the Royal Society of Medicine

Published
2023
Full Text
View/download PDF

21. sj-pdf-5-jrs-10.1177_01410768231182389 - Supplemental material for COVID-19 risk mitigation in reopening mass cultural events: population-based observational study for the UK Events Research Programme in Liverpool City Region

Author

Burnside, Girvan, Cheyne, Christopher P, Leeming, Gary, Humann, Michael, Darby, Alistair, Green, Mark A, Crozier, Alexander, Maskell, Simon, O’Halloran, Kay, Musi, Elena, Carmi, Elinor, Khan, Naila, Fisher, Debra, Corcoran, Rhiannon, Dunning, Jake, Edmunds, W John, Tharmaratnam, Kukatharmini, Hughes, David M, Malki-Epshtein, Liora, Cook, Malcolm, Roberts, Ben M, Gallagher, Eileen, Howell, Kate, Chand, Meera, Kemp, Robin, Boulter, Matthew, Fowler, Tom, Semple, Malcolm G, Coffey, Emer, Ashton, Matt, García-Fiñana, Marta, and Buchan, Iain E

Subjects
Medicine
Abstract

Supplemental material, sj-pdf-5-jrs-10.1177_01410768231182389 for COVID-19 risk mitigation in reopening mass cultural events: population-based observational study for the UK Events Research Programme in Liverpool City Region by Girvan Burnside, Christopher P Cheyne, Gary Leeming, Michael Humann, Alistair Darby, Mark A Green, Alexander Crozier, Simon Maskell, Kay O’Halloran, Elena Musi, Elinor Carmi, Naila Khan, Debra Fisher, Rhiannon Corcoran, Jake Dunning, W John Edmunds, Kukatharmini Tharmaratnam, David M Hughes, Liora Malki-Epshtein, Malcolm Cook, Ben M Roberts, Eileen Gallagher, Kate Howell, Meera Chand, Robin Kemp, Matthew Boulter, Tom Fowler, Malcolm G Semple, Emer Coffey, Matt Ashton, The COVID-19 Genomics UK (COG-UK) Consortium, Marta García-Fiñana and Iain E Buchan in Journal of the Royal Society of Medicine

Published
2023
Full Text
View/download PDF

22. sj-pdf-1-jrs-10.1177_01410768231182389 - Supplemental material for COVID-19 risk mitigation in reopening mass cultural events: population-based observational study for the UK Events Research Programme in Liverpool City Region

Author

Burnside, Girvan, Cheyne, Christopher P, Leeming, Gary, Humann, Michael, Darby, Alistair, Green, Mark A, Crozier, Alexander, Maskell, Simon, O’Halloran, Kay, Musi, Elena, Carmi, Elinor, Khan, Naila, Fisher, Debra, Corcoran, Rhiannon, Dunning, Jake, Edmunds, W John, Tharmaratnam, Kukatharmini, Hughes, David M, Malki-Epshtein, Liora, Cook, Malcolm, Roberts, Ben M, Gallagher, Eileen, Howell, Kate, Chand, Meera, Kemp, Robin, Boulter, Matthew, Fowler, Tom, Semple, Malcolm G, Coffey, Emer, Ashton, Matt, García-Fiñana, Marta, and Buchan, Iain E

Subjects
Medicine
Abstract

Supplemental material, sj-pdf-1-jrs-10.1177_01410768231182389 for COVID-19 risk mitigation in reopening mass cultural events: population-based observational study for the UK Events Research Programme in Liverpool City Region by Girvan Burnside, Christopher P Cheyne, Gary Leeming, Michael Humann, Alistair Darby, Mark A Green, Alexander Crozier, Simon Maskell, Kay O’Halloran, Elena Musi, Elinor Carmi, Naila Khan, Debra Fisher, Rhiannon Corcoran, Jake Dunning, W John Edmunds, Kukatharmini Tharmaratnam, David M Hughes, Liora Malki-Epshtein, Malcolm Cook, Ben M Roberts, Eileen Gallagher, Kate Howell, Meera Chand, Robin Kemp, Matthew Boulter, Tom Fowler, Malcolm G Semple, Emer Coffey, Matt Ashton, The COVID-19 Genomics UK (COG-UK) Consortium, Marta García-Fiñana and Iain E Buchan in Journal of the Royal Society of Medicine

Published
2023
Full Text
View/download PDF

23. 3-D MRI Brain Scan Classification Using A Point Series Based Representation

Author

Udomchaiporn, Akadej, Coenen, Frans, García-Fiñana, Marta, Sluming, Vanessa, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Kobsa, Alfred, Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Bellatreche, Ladjel, editor, and Mohania, Mukesh K., editor

Published
2014
Full Text
View/download PDF

24. Neurodevelopment of babies born to mothers with epilepsy: A prospective observational cohort study.

Author

Bromley, Rebecca L., Bullen, Philip, Campbell, Ellen, Craig, John, Ingham, Amy, Irwin, Beth, Jackson, Cerain, Kelly, Teresa, Morrow, James, Rushton, Sarah, García‐Fiñana, Marta, Hughes, David M., Winterbottom, Janine, Wood, Amanda, Yates, Laura M., Clayton‐Smith, Jill, Bromley, Rebecca, Jackson, Cerian, Bullen, Phil, and Riley, Lauren

Subjects
TODDLERS development, MOTHERS, COHORT analysis, INFANT development, EPILEPSY
Abstract

Objective: Despite widespread monotherapy use of lamotrigine or levetiracetam during pregnancy, prospectively collected, blinded child development data are still limited. The NaME (Neurodevelopment of Babies Born to Mothers With Epilepsy) Study prospectively recruited a new cohort of women with epilepsy and their offspring for longitudinal follow‐up. Methods: Pregnant women of <21 weeks gestation (n = 401) were recruited from 21 hospitals in the UK. Data collection occurred during pregnancy (recruitment, trimester 3) and at 12 and 24 months of age. The primary outcome was blinded assessment of infant cognitive, language, and motor development on the Bayley Scales of Infant and Toddler Development (3rd edition) at 24 months of age with supplementary parent reporting on the Vinelands Adaptive Behavior Scales (2nd edition). Results: There were 394 live births, with 277 children (70%) completing the Bayley assessment at 24 months. There was no evidence of an association of prenatal exposure to monotherapy lamotrigine (−.74, SE = 2.9, 95% confidence interval [CI] = −6.5 to 5.0, p =.80) or levetiracetam (−1.57, SE = 3.1, 95% CI = −4.6 to 7.7, p =.62) with poorer infant cognition, following adjustment for other maternal and child factors in comparison to nonexposed children. Similar results were observed for language and motor scores. There was no evidence of an association between increasing doses of either lamotrigine or levetiracetam. Nor was there evidence that higher dose folic acid supplementation (≥5 mg/day) or convulsive seizure exposure was associated with child development scores. Continued infant exposure to antiseizure medications through breast milk was not associated with poorer outcomes, but the number of women breastfeeding beyond 3 months was low. Significance: These data are reassuring for infant development following in utero exposure to monotherapy lamotrigine or levetiracetam, but child development is dynamic, and future follow‐up is required to rule out later emerging effects. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

27. 3-D MRI Brain Scan Feature Classification Using an Oct-Tree Representation

Author

Udomchaiporn, Akadej, Coenen, Frans, García-Fiñana, Marta, Sluming, Vanessa, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Goebel, Randy, editor, Siekmann, Jörg, editor, Wahlster, Wolfgang, editor, Motoda, Hiroshi, editor, Wu, Zhaohui, editor, Cao, Longbing, editor, Zaiane, Osmar, editor, Yao, Min, editor, and Wang, Wei, editor

Published
2013
Full Text
View/download PDF

28. Time Series Case Based Reasoning for Image Categorisation

Author

Elsayed, Ashraf, Hijazi, Mohd Hanafi Ahmad, Coenen, Frans, García-Fiñana, Marta, Sluming, Vanessa, Zheng, Yalin, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Goebel, Randy, editor, Siekmann, Jörg, editor, Wahlster, Wolfgang, editor, Ram, Ashwin, editor, and Wiratunga, Nirmalie, editor

Published
2011
Full Text
View/download PDF

29. Region of Interest Based Image Categorization

Author

Elsayed, Ashraf, Coenen, Frans, García-Fiñana, Marta, Sluming, Vanessa, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Bach Pedersen, Torben, editor, Mohania, Mukesh K., editor, and Tjoa, A Min, editor

Published
2010
Full Text
View/download PDF

32. Phase I/II Clinical Trials of Donor-Derived Purified Regulatory T Cells for the Treatment of Steroid-Refractory Chronic Graft Versus Host Disease

Author

Soares, Maria VD, Escamilla Gomez, Virginia, Azevedo, Rita I, Pereira, Paulo N.G., Velázquez, Teresa Caballero, Garcia-Calderón, Clara B., Tharmaratnam, Kukatharmini, Cabral, Inês A, Ribeiro, Ana C, Mendes, Laura, Juncal, Clara, Roncon, Susana, Pais, Ana Teresa, Alho, Ana C, Rodriguez Gil, Alfonso, Espada, Eduardo L, Rodrigues, Anabela, Garção, Ana, Yaspo, Marie-Laure, Warnatz, Hans-Jörg, Lehrach, Hans, Barbosa-Morais, Nuno L., Quintas, Ana Miguel, Palmela, Paulo, Caldas, Cecilia, Ferreira, Rosa, Leite, Luis, Martins, Carlos, Lourenço, Fernanda, Moreno, Raúl, Raposo, João, Campilho, Fernando, Cheyne, Christopher Paul, Garcia-Fiñana, Marta, Campos, António, Baron, Frédéric, Arpinati, Mario, Edinger, Matthias, Ritz, Jerome, Vaz, Carlos Pinho, Perez-Simon, Jose A., and Lacerda, Joao F

Published
2022
Full Text
View/download PDF

36. Rapid antigen testing in COVID-19 management for school-aged children: an observational study in Cheshire and Merseyside, UK.

Author

Hughes, David M, Bird, Sheila M, Cheyne, Christopher P, Ashton, Matthew, Campbell, Melisa C, García-Fiñana, Marta, and Buchan, Iain

Subjects
ANTIGEN analysis, STUDENT health, REVERSE transcriptase polymerase chain reaction, COVID-19, SCIENTIFIC observation, CONFIDENCE intervals, PEARSON correlation (Statistics), DESCRIPTIVE statistics, RESEARCH funding, COVID-19 testing, HEALTH equity, ODDS ratio, CHILDREN
Abstract

Background Twice weekly lateral flow tests (LFTs) for secondary school children was UK Government policy from 8 March 2021. We evaluate use of LFTs (both supervised at test centres, and home test kits) in school-aged children in Cheshire and Merseyside. Methods We report (i) number of LFT positives (ii) proportion of LFT positive with confirmatory reverse transcription polymerase chain reaction (PCR) test within 2 days, and (iii) agreement between LFT-positive and confirmatory PCR, and dependence of (i–iii) on COVID-19 prevalence. Findings 1 248 468 LFTs were taken by 211 255 12–18 years old, and 163 914 by 52 116 5–11 years old between 6 November 2020 and 31 July 2021. Five thousand three hundred and fourteen (2.5%) 12–18 years old and 1996 (3.8%) 5–11 years old returned LFT positives, with 3829 (72.1%) and 1535 (76.9%) confirmatory PCRs, and 3357 (87.7%) and 1383 (90.1%) confirmatory PCR-positives, respectively. Monthly proportions of LFT positive with PCR negative varied between 4.7% and 35.3% in 12–18 years old (corresponding proportion of all tests positive: 9.7% and 0.3%). Deprivation and non-White ethnicity were associated with reduced uptake of confirmatory PCR. Interpretation Substantial inequalities in confirmatory testing need more attention to avoid further disadvantage through education loss. When prevalence is low additional measures, including confirmatory testing, are needed. Local Directors of Public Health taking more control over schools testing may be needed. Funding DHSC, MRC, NIHR, EPSRC. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

37. Fast approximate inference for multivariate longitudinal data.

Author

Hughes, David M, García-Fiñana, Marta, and Wand, Matt P

Subjects
*MARKOV chain Monte Carlo, *PANEL analysis, *BILIARY liver cirrhosis, *BIG data, *COMPUTATIONAL neuroscience, *DIABETIC retinopathy
Abstract

Collecting information on multiple longitudinal outcomes is increasingly common in many clinical settings. In many cases, it is desirable to model these outcomes jointly. However, in large data sets, with many outcomes, computational burden often prevents the simultaneous modeling of multiple outcomes within a single model. We develop a mean field variational Bayes algorithm, to jointly model multiple Gaussian, Poisson, or binary longitudinal markers within a multivariate generalized linear mixed model. Through simulation studies and clinical applications (in the fields of sight threatening diabetic retinopathy and primary biliary cirrhosis), we demonstrate substantial computational savings of our approximate approach when compared to a standard Markov Chain Monte Carlo, while maintaining good levels of accuracy of model parameters. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

46. Effectiveness of the BNT162b2 (Pfizer-BioNTech) and the ChAdOx1 nCoV-19 (Oxford-AstraZeneca) vaccines for reducing susceptibility to infection with the Delta variant (B.1.617.2) of SARS-CoV-2

Author

Pattni, Karan, primary, Hungerford, Daniel, additional, Adams, Sarah, additional, Buchan, Iain, additional, Cheyne, Christopher P, additional, García-Fiñana, Marta, additional, Hall, Ian, additional, Hughes, David M, additional, Overton, Christopher, additional, Zhang, Xingna, additional, and Sharkey, Kieran J., additional

Published
2021
Full Text
View/download PDF

47. Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK

Author

Docherty, Annemarie B, Mulholland, Rachel H, Lone, Nazir I, Cheyne, Christopher P, De Angelis, Daniela, Diaz-Ordaz, Karla, Donegan, Cara, Drake, Thomas M, Dunning, Jake, Funk, Sebastian, García-Fiñana, Marta, Girvan, Michelle, Hardwick, Hayley E, Harrison, Janet, Ho, Antonia, Hughes, David M, Keogh, Ruth H, Kirwan, Peter D, Leeming, Gary, Nguyen Van-Tam, Jonathan S, Pius, Riinu, Russell, Clark D, Spencer, Rebecca G, Tom, Brian Dm, Turtle, Lance, Openshaw, Peter Jm, Baillie, J Kenneth, Harrison, Ewen M, Semple, Malcolm G, and ISARIC4C Investigators

Abstract

BACKGROUND: Mortality rates in hospitalised patients with COVID-19 in the UK appeared to decline during the first wave of the pandemic. We aimed to quantify potential drivers of this change and identify groups of patients who remain at high risk of dying in hospital. METHODS: In this multicentre prospective observational cohort study, the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK recruited a prospective cohort of patients with COVID-19 admitted to 247 acute hospitals in England, Scotland, and Wales during the first wave of the pandemic (between March 9 and Aug 2, 2020). We included all patients aged 18 years and older with clinical signs and symptoms of COVID-19 or confirmed COVID-19 (by RT-PCR test) from assumed community-acquired infection. We did a three-way decomposition mediation analysis using natural effects models to explore associations between week of admission and in-hospital mortality, adjusting for confounders (demographics, comorbidities, and severity of illness) and quantifying potential mediators (level of respiratory support and steroid treatment). The primary outcome was weekly in-hospital mortality at 28 days, defined as the proportion of patients who had died within 28 days of admission of all patients admitted in the observed week, and it was assessed in all patients with an outcome. This study is registered with the ISRCTN Registry, ISRCTN66726260. FINDINGS: Between March 9, and Aug 2, 2020, we recruited 80 713 patients, of whom 63 972 were eligible and included in the study. Unadjusted weekly in-hospital mortality declined from 32·3% (95% CI 31·8-32·7) in March 9 to April 26, 2020, to 16·4% (15·0-17·8) in June 15 to Aug 2, 2020. Reductions in mortality were observed in all age groups, in all ethnic groups, for both sexes, and in patients with and without comorbidities. After adjustment, there was a 32% reduction in the risk of mortality per 7-week period (odds ratio [OR] 0·68 [95% CI 0·65-0·71]). The higher proportions of patients with severe disease and comorbidities earlier in the first wave (March and April) than in June and July accounted for 10·2% of this reduction. The use of respiratory support changed during the first wave, with gradually increased use of non-invasive ventilation over the first wave. Changes in respiratory support and use of steroids accounted for 22·2%, OR 0·95 (0·94-0·95) of the reduction in in-hospital mortality. INTERPRETATION: The reduction in in-hospital mortality in patients with COVID-19 during the first wave in the UK was partly accounted for by changes in the case-mix and illness severity. A significant reduction in in-hospital mortality was associated with differences in respiratory support and critical care use, which could partly reflect accrual of clinical knowledge. The remaining improvement in in-hospital mortality is not explained by these factors, and could be associated with changes in community behaviour, inoculum dose, and hospital capacity strain. FUNDING: National Institute for Health Research and the Medical Research Council.

Published
2021

48. Impact of community asymptomatic rapid antigen testing on covid-19 related hospital admissions: synthetic control study.

Author

Xingna Zhang, Barr, Ben, Green, Mark, Hughes, David, Ashton, Matthew, Charalampopoulos, Dimitrios, García-Fiñana, Marta, and Buchan, Iain

Subjects
COVID-19, SARS-CoV-2, CONFIDENCE intervals, POST-acute COVID-19 syndrome, PATIENTS, COMMUNITY health services, PUBLIC health, HOSPITAL admission & discharge, COMPARATIVE studies, HOSPITAL care, DESCRIPTIVE statistics, COVID-19 testing, SOCIODEMOGRAPHIC factors, STAY-at-home orders, ISOLATION (Hospital care), PATIENT self-monitoring
Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results