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Berta García-Tomás, José María Marín-Sánchez, Christian García-Elskamp, Encarnación Alcon-Ruiz, Laura Montesinos-López, Beatriz García Martínez-Lozano Cataract and Refractive Surgery Department, Murcia, 30009, SpainCorrespondence: Berta García-Tomás, Cataract and Refractive Surgery Department, Oftalvist Murcia, Ronda Norte 21, Murcia, 30009, Spain, Tel +968 281 060, Email bgarciatomas@gmail.comPurpose: To evaluate the refractive and visual outcomes of eyes implanted with monofocal, optimized, aspheric, hydrophobic acrylic intraocular lenses (IOL) following cataract surgery.Methods: The study assessed 55 eyes implanted with CT LUCIA® 621P IOLs (Carl Zeiss Meditec AG, Jena, Germany) at 3-months postsurgery. The main outcome measures were refractive error, monocular corrected distance visual acuity (CDVA), monocular uncorrected distance visual acuity (UDVA), photopic and mesopic contrast sensitivity, and wavefront aberrations. Patients were asked to complete the Catquest-9SF questionnaire.Results: At 3 months, the cumulative Snellen visual acuity was 20/20 in 94.55% of eyes and 20/25 or better in 100%. The difference between the UDVA and CDVA was either the same (70.91%) or better (29.09%) in all eyes. The mean Snellen decimal UDVA and DCVA were 1.07 ± 0.15 and 1.13 ± 0.11, respectively. The safety and efficacy indexes were 1.48 and 1.40, respectively. 47.27% of eyes showed a spherical equivalent ± 0.13 D, with 92.73% of the eyes were within ± 0.50 D and all eyes were within ± 1.00 D. The mean spherical equivalent was − 0.03 ± 0.30 D and the mean refractive cylinder − 0.36 ± 0.34 D. The log photopic and mesopic contrast sensitivity functions were good and similar for all spatial frequencies. All patients reported being either fairly satisfied (score 3) or very satisfied (score 4) with their vision (mean = 3.64 ± 0.49). No intra- and postoperative complications were reported during the 3 months of follow-up.Conclusion: The current study demonstrates that excellent visual and refractive outcomes, as well as patient satisfaction, can be achieved after cataract surgery with optimized, aspheric CT LUCIA 621P monofocal IOLs.Keywords: cataract, intraocular lens, aspheric, aberrations, contrast sensitivity, phacoemulsification