72 results on '"García Velloso MJ"'
Search Results
2. Diagnosis of giant cell arteritis by 18F-FDG PET/CT in patients on glucocorticoid therapy: importance of delayed imaging.
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Aldasoro V, Betech-Antar V, Castañeda S, de Miguel E, Rosales JJ, and García-Velloso MJ
- Abstract
Objectives: The aim of this study is to analyse the diagnostic value of positron emission tomography (PET) in patients with giant cell arteritis (GCA) despite glucocorticoid (GC) therapy before PET acquisition., Methods: Consecutive patients with strongly suspected GCA according to 2022 EULAR/ACR criteria were included. The physician diagnosis of GCA after 6 months of follow-up was the gold standard. PET was performed at baseline and 6 months later. In patients with negative results at 60 min, delayed imaging was performed at 180 min., Results: Twenty-six patients were included with a median (IQR) age of 70.5 (57-88) years. Baseline PET was positive in all but one: 18 patients at 60 min and 7 patients after delayed imaging at 180 min. The median (IQR) GC dose at the time of baseline PET was 45 mg/d (26.2-45) of prednisone equivalent with a median exposure of 14 days (7-76.2). At 6 months of follow-up, PET was performed in 22 patients, with positive results in 16. Delayed imaging was performed in 6 patients due to negative PET at 60 min, with positive results in all cases, despite treatment with GC and/or biological therapy., Conclusions: In patients on GC therapy, delayed imaging protocols applying procedural recommendations for vascular quantification could improve diagnostic accuracy. Therefore, we suggest performing imaging only at 180 min in patients who have been on GCs for more than 3 days as well as in those with highly suspected GCA but negative findings in baseline PET at 60 min.
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- 2024
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3. Continuous innovation in precision radio-guided surgery.
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Vidal-Sicart S, Goñi E, Cebrecos I, Rioja ME, Perissinotti A, Sampol C, Vidal O, Saavedra-Pérez D, Ferrer A, Martí C, Ferrer Rebolleda J, García Velloso MJ, Orozco-Cortés J, Díaz-Feijóo B, Niñerola-Baizán A, and Valdés Olmos RA
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- Humans, Artificial Intelligence, Sentinel Lymph Node Biopsy methods, Single Photon Emission Computed Tomography Computed Tomography, Melanoma, Surgery, Computer-Assisted methods
- Abstract
Since its origins, nuclear medicine has faced technological changes that led to modifying operating modes and adapting protocols. In the field of radioguided surgery, the incorporation of preoperative scintigraphic imaging and intraoperative detection with the gamma probe provided a definitive boost to sentinel lymph node biopsy to become a standard procedure for melanoma and breast cancer. The various technological innovations and consequent adaptation of protocols come together in the coexistence of the disruptive and the gradual. As obvious examples we have the introduction of SPECT/CT in the preoperative field and Drop-in probes in the intraoperative field. Other innovative aspects with possible application in radio-guided surgery are based on the application of artificial intelligence, navigation and telecare., (Copyright © 2023 Sociedad Española de Medicina Nuclear e Imagen Molecular. Published by Elsevier España, S.L.U. All rights reserved.)
- Published
- 2024
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4. Syphilis Mimicking Malignant Pulmonary Tumor With Nodal and Bone Metastasis on 18 F-FDG PET/CT.
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Bronte Viedma A, Menendez-Sanchez S, Bastidas Tamayo JF, Lajusticia Andrés H, and García-Velloso MJ
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- Male, Humans, Middle Aged, Positron Emission Tomography Computed Tomography, Fluorodeoxyglucose F18, Radiopharmaceuticals, Syphilis, Lung Neoplasms diagnostic imaging, Lung Neoplasms pathology, Bone Neoplasms
- Abstract
Abstract: A 52-year-old man suffering left pleuritic pain underwent a chest CT showing a subpleural pulmonary nodule in the left upper lobe. Because of the possibility of a lung tumor, he was referred for 18 F-FDG PET/CT. The scan revealed FDG uptake in the pulmonary nodule, in an upper right paratracheal lymph node, and at 4 destructive bone lesions. Pathologic examination after pulmonary biopsy manifested only the presence of inflammatory cells. Further clinical history research proved risky sexual behavior with a positive syphilis serology test. A follow-up PET/CT 7 months after penicillin therapy showed a complete metabolic response of all the lesions., Competing Interests: Conflicts of interest and sources of funding: none declared., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2023
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5. Lung cancer screening using low-dose CT and FDG-PET in liver transplant recipients.
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Caballeros Lam M, Pujols P, Ezponda Casajús A, Guillén Valderrama F, García Velloso MJ, Wyss A, García Del Barrio L, Larrache Latasa J, Pueyo Villoslada J, Lozano Escario MD, de-Torres JP, Alcaide Ocaña AB, Campo Ezquibela A, Seijo Maceiras L, Montuenga Badía L, Zulueta J, Iñarrairaegui Bastarrica M, Herrero Santos I, and Bastarrika Alemañ G
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- Humans, Male, Female, Fluorodeoxyglucose F18, Early Detection of Cancer methods, Radiopharmaceuticals, Positron-Emission Tomography, Tomography, X-Ray Computed, Retrospective Studies, Lung Neoplasms diagnostic imaging, Lung Neoplasms epidemiology, Lung Neoplasms surgery, Liver Transplantation adverse effects
- Abstract
To address the feasibility of implementing a lung cancer screening program in liver transplant recipients (LTR) targeted to detect early-stage lung cancer one hundred twenty-four LTR (89% male, 59.8+/-8.8 y old), who entered the lung cancer screening program at our hospital were reviewed. The results of the diagnostic algorithm using low-dose CT and F-18-fluorodeoxyglycose positron emission tomography (FDG-PET) were analyzed. Lung cancer was detected in 12 LTR (9.7%), most of which corresponded to the non-small cell subtype. Two of the 12 lung cancers were detected in the baseline study (prevalence of 1.6%), whereas 10 patients were diagnosed with lung cancer in the follow-up (incidence of 8.1%). Considering all cancers, 10 of 12 (83.3%) were diagnosed at stage I, one cancer was diagnosed at stage IIIA, and another one at stage IV. The sensitivity, specificity, diagnostic accuracy, and positive and negative predictive values of F-18-fluorodeoxyglycose positron emission tomography to detect malignancy in our cohort were 81.8%,100%, 99.3%, 100%, and 99.3%, respectively. A carefully followed multidisciplinary lung cancer screening algorithm in LTR that includes F-18-fluorodeoxyglycose positron emission tomography and low-dose CT allows lung cancer to be diagnosed at an early stage while reducing unnecessary invasive procedures., (Copyright © 2023 American Association for the Study of Liver Diseases.)
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- 2023
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6. Disseminated lymphadenopathy during chemotherapy for squamous cell lung carcinoma.
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Villar S, Sogbe M, García-Velloso MJ, and Del Pozo JL
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- Humans, Lung pathology, Epithelial Cells pathology, Carcinoma, Squamous Cell drug therapy, Carcinoma, Squamous Cell pathology, Lymphadenopathy etiology
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- 2023
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7. FDG-PET/CT and new radiopharmaceuticals in patients with multiple myeloma.
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Morales Lozano MI and García-Velloso MJ
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- Humans, Aged, Adult, Radiopharmaceuticals, Fluorodeoxyglucose F18, Positron Emission Tomography Computed Tomography, Positron-Emission Tomography, Multiple Myeloma pathology
- Abstract
Multiple myeloma is a monoclonal gammopathy, a clonal proliferative disorder of plasma cells that produces a protein called M or myeloma protein in the bone marrow, usually IgG or IgA. It accounts for 1% in the general cancer statistics and represents 10% of all hematologic tumours, with a cumulative incidence in Spain of about 5/100,000/year. The incidence increases with age, so that 50% of cases are diagnosed in patients over 75 years of age, being infrequent in the population under 40 years of age. This publication details the indications of FDG PET/CT for the staging and response assessment in patients with MM, accepted by the international working group on myeloma, as well as new molecular imaging radiopharmaceuticals with potential value for personalised medicine., (Copyright © 2023 Sociedad Española de Medicina Nuclear e Imagen Molecular. Published by Elsevier España, S.L.U. All rights reserved.)
- Published
- 2023
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8. Pancreatic involvement in a patient with multiple myeloma revealed by [ 18 F]FDG PET/CT. A rare manifestation of extramedullary disease.
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Bronte A, Rosales JJ, Bastidas JF, Lozano MD, Rodriguez P, and García-Velloso MJ
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- Humans, Multimodal Imaging, Positron Emission Tomography Computed Tomography, Positron-Emission Tomography, Fluorodeoxyglucose F18, Multiple Myeloma complications, Multiple Myeloma diagnostic imaging
- Published
- 2022
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9. SEMNIM, the power of all of us.
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García Velloso MJ, Becerra García D, Peña C, Ruano R, Fernández I, Gómez A, Mitjavila M, Estorch M, and Manuel Cordero J
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- 2021
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10. Early Imaging and Molecular Changes with Neoadjuvant Bevacizumab in Stage II/III Breast Cancer.
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López-Vega JM, Álvarez I, Antón A, Illarramendi JJ, Llombart A, Boni V, García-Velloso MJ, Martí-Climent JM, Pina L, and García-Foncillas J
- Abstract
This prospective, phase II study evaluated novel biomarkers as predictors of response to bevacizumab in patients with breast cancer (BC), using serial imaging methods and gene expression analysis. Patients with primary stage II/III BC received bevacizumab 15 mg/kg (cycle 1; C1), then four cycles of neoadjuvant docetaxel doxorubicin, and bevacizumab every 3 weeks (C2-C5). Tumour proliferation and hypoxic status were evaluated using
18 F-fluoro-3'-deoxy-3'-L-fluorothymidine (FLT)- and18 F-fluoromisonidazole (FMISO)-positron emission tomography (PET) at baseline, and during C1 and C5. Pre- and post-bevacizumab vascular changes were evaluated using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Molecular biomarkers were assessed using microarray analysis. A total of 70 patients were assessed for treatment efficacy. Significant decreases from baseline in tumour proliferation (FLT-PET), vascularity, and perfusion (DCE-MRI) were observed during C1 ( p ≤ 0.001), independent of tumour subtype. Bevacizumab treatment did not affect hypoxic tumour status (FMISO-PET). Significant changes in the expression of 28 genes were observed after C1. Changes in vascular endothelial growth factor receptor (VEGFR)-2p levels were observed in 65 patients, with a > 20% decrease in VEGFR-2p observed in 13/65. Serial imaging techniques and molecular gene profiling identified several potentially predictive biomarkers that may predict response to neoadjuvant bevacizumab therapy in BC patients.- Published
- 2021
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11. Diagnostic accuracy of visual analysis versus dual time-point imaging with 18 F-FDG PET/CT for the characterization of indeterminate pulmonary nodules with low uptake.
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Grisanti F, Zulueta J, Rosales JJ, Morales MI, Sancho L, Lozano MD, Mesa-Guzmán M, and García-Velloso MJ
- Abstract
Objective: To determine the accuracy of visual analysis and the retention index (RI) with dual-time point
18 F-FDG PET/CT for the characterization of indeterminate pulmonary nodules (IPN) with low FDG uptake., Materials and Methods: A retrospective analysis was performed on 43 patients (28 men, 64 ± 11 years old, range 36-83 years) referred for IPN characterization with18 F-FDG-PET/CT and maximum standard uptake value ≤ 2.5 at 60 minutes post-injection (SUVmax1 ). Nodules were analyzed by size, visual score for FDG uptake on standard (OSEM 2,8) and high definition (HD) reconstructions, SUVmax1 , SUVmax at 180 minutes post-injection (SUVmax2 ), and RI was calculated. The definitive diagnosis was based on histopathological confirmation (n = 28) or ≥ 2 years of follow-up., Results: Twenty-four (56%) nodules were malignant. RI ≥ 10% on standard reconstruction detected 18 nodules that would have been considered negative using the standard SUVmax ≥ 2.5 criterion for malignancy. RI ≥ 10% had a sensitivity, specificity, PPV, NPV and accuracy of 75, 73.7, 78.3, 70, and 74.4%, respectively, while for FDG uptake > liver on HD these were 79.1, 63.2, 73.1, 70.6, and 72.1%, respectively. SUVmax1 ≥ 2, SUVmax2 > 2.5 and FDG uptake > liver on standard reconstruction had a PPV of 100%. FDG uptake > mediastinum on HD had a NPV of 100%., Conclusions: RI ≥ 10% was the most accurate criterion for malignancy, followed by FDG uptake > liver on HD reconstruction. On standard reconstruction, SUVmax1 ≥2 was highly predictive of malignancy, as well as SUVmax2 > 2.5 and FDG uptake > liver. FDG uptake < mediastinum on HD was highly predictive of benign nodules., (Copyright © 2020 Sociedad Española de Medicina Nuclear e Imagen Molecular. Publicado por Elsevier España, S.L.U. All rights reserved.)- Published
- 2021
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12. Ultra-low dose whole-body CT for attenuation correction in a dual tracer PET/CT protocol for multiple myeloma.
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Prieto E, García-Velloso MJ, Aquerreta JD, Rosales JJ, Bastidas JF, Soriano I, Irazola L, Rodríguez-Otero P, Quincoces G, and Martí-Climent JM
- Subjects
- Artifacts, Humans, Phantoms, Imaging, Positron-Emission Tomography, Retrospective Studies, Tomography, X-Ray Computed, Multiple Myeloma diagnostic imaging, Positron Emission Tomography Computed Tomography
- Abstract
Purpose: To investigate within phantoms the minimum CT dose allowed for accurate attenuation correction of PET data and to quantify the effective dose reduction when a CT for this purpose is incorporated in the clinical setting., Methods: The NEMA image quality phantom was scanned within a large parallelepiped container. Twenty-one different CT images were acquired to correct attenuation of PET raw data. Radiation dose and image quality were evaluated. Thirty-one patients with proven multiple myeloma who underwent a dual tracer PET/CT scan were retrospectively reviewed.
18 F-fluorodeoxyglucose PET/CT included a diagnostic whole-body low dose CT (WBLDCT: 120 kV-80mAs) and11 C-Methionine PET/CT included a whole-body ultra-low dose CT (WBULDCT) for attenuation correction (100 kV-40mAs). Effective dose and image quality were analysed., Results: Only the two lowest radiation dose conditions (80 kV-20mAs and 80 kV-10mAs) produced artifacts in CT images that degraded corrected PET images. For all the other conditions (CTDIvol ≥ 0.43 mGy), PET contrast recovery coefficients varied less than ± 1.2%. Patients received a median dose of 6.4 mSv from diagnostic CT and 2.1 mSv from the attenuation correction CT. Despite the worse image quality of this CT, 94.8% of bone lesions were identifiable., Conclusion: Phantom experiments showed that an ultra-low dose CT can be implemented in PET/CT procedures without any noticeable degradation in the attenuation corrected PET scan. The replacement of the standard CT for this ultra-low dose CT in clinical PET/CT scans involves a significant radiation dose reduction., (Copyright © 2021 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.)- Published
- 2021
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13. Immunotherapy, cancer and PET.
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Simó-Perdigó M, Vercher-Conejero JL, Viteri S, and García-Velloso MJ
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The treatment of cancer by immunotherapy has been a revolution, as it is the first strategy that manages to control the disease for prolonged periods of time. Its efficacy is associated with different imaging response patterns and the appearance of new toxicities. We would highlight two patterns of tumour response: pseudoprogression, or growth of tumour lesions after the start of immunotherapy treatment, followed by a significant reduction in lesions, and hyperprogression, acceleration of tumour progression and metastasis early after the start of treatment. The emergence of such patterns has generated new metabolic response criteria, such as PECRIT, PERCIMT, imPERCIST and IPERCIST. Of particular interest are the new immunoPET-specific biomarkers, as they allow the identification of patients presenting the tumour target and are useful for predicting response to immunotherapy., (Copyright © 2021 Sociedad Española de Medicina Nuclear e Imagen Molecular. Publicado por Elsevier España, S.L.U. All rights reserved.)
- Published
- 2021
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14. Pulmonary Artery Sarcoma With Low 18F-FDG Uptake.
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Rosales Castillo JJ, García L, Bastidas JF, Bronte Á, and García-Velloso MJ
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- Aged, Biological Transport, Humans, Male, Fluorodeoxyglucose F18 metabolism, Positron Emission Tomography Computed Tomography, Pulmonary Artery diagnostic imaging, Sarcoma diagnostic imaging, Sarcoma metabolism, Vascular Neoplasms diagnostic imaging, Vascular Neoplasms metabolism
- Abstract
Abstract: A 75-year-old man presented with dyspnea for more than 2 months, with blood test showing low platelet count and cardiac ultrasound showing severe pulmonary hypertension (>54 mm Hg). A CT pulmonary angiogram showed a filling defect in the pulmonary trunk, right and left pulmonary arteries, raising the possibilities of pulmonary embolism or artery sarcoma. FDG PET/CT was performed for further evaluation and showed low uptake in the pulmonary wall, which supported the diagnosis of pulmonary embolism. Patient was treated with anticoagulants with no changes on repeated CT pulmonary angiogram. Patient underwent surgery, and histopatological examination revealed a pulmonary artery sarcoma., Competing Interests: Conflicts of interest and sources of funding: none declared., (Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2021
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15. The utility of ADC value in diffusion-weighted whole-body MRI in the follow-up of patients with multiple myeloma. Correlation study with 18 F-FDG PET-CT.
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Paternain A, García-Velloso MJ, Rosales JJ, Ezponda A, Soriano I, Elorz M, Rodríguez-Otero P, and Aquerreta JD
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- Correlation of Data, Diffusion Magnetic Resonance Imaging, Follow-Up Studies, Humans, Magnetic Resonance Imaging, Positron Emission Tomography Computed Tomography, Positron-Emission Tomography, Radiopharmaceuticals, Retrospective Studies, Fluorodeoxyglucose F18, Multiple Myeloma diagnostic imaging
- Abstract
Objectives: To analyze the feasibility of DWI-MRI and ADC to evaluate treatment response in patients with multiple myeloma (MM). To correlate the variations of ADC and SUVmax in
18 F-FDG PET-CT., Methods: 27 patients with MM that had a whole-body MRI and18 F-FDG PET-CT performed at baseline and after treatment were retrospectively recruited between February 2018 and May 2020. Three target bone lesions were selected for each patient and their ADC, SUVmax and Deauville score were measured in every study. Correlation between ADC and SUVmax of the lesions was evaluated, as well as changes in mean ADC, SUVmax, and Deauville score between studies. Patients were classified as responder or non-responder according to the IMWG, MRI (MY-RADS) and PET-CT (IMPeTUs) response criteria. Agreement between the MRI and PET-CT criteria with the IMWG criteria was evaluated., Results: The correlation between the ADC and SUVmax of all the target lesions was strong, negative and significant (r=-0.603; p < 0.001). After treatment, mean ADC in lesions from responders was significantly higher than in non-responders (1585.51 × 10-6 mm2 /s vs 698.17 × 10-6 mm2 /s; p < 0.001). SUVmax of the same lesions was significantly lower in responders than in non-responders (2.05 vs 5.33; p < 0.001). There was a very strong or strong agreement of the IMWG response criteria with both MRI (κ = 0.852; p < 0.001) and PET (κ = 0.767; p < 0.001) criteria., Conclusion: DWI-MRI and ADC may be used to assess treatment response in MM patients, showing a good correlation with18 F-FDG PET-CT and the IMWG response criteria., (Copyright © 2020 Elsevier B.V. All rights reserved.)- Published
- 2020
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16. Elevated circulating metalloproteinase 7 predicts recurrent cardiovascular events in patients with carotid stenosis: a prospective cohort study.
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Moreno-Ajona D, Irimia P, Rodríguez JA, García-Velloso MJ, López-Fidalgo J, Fernández-Alonso L, Grochowitz L, Muñoz R, Domínguez P, Gállego-Culleré J, and Martínez-Vila E
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- Aged, Asymptomatic Diseases, Biomarkers blood, Cardiovascular Diseases diagnostic imaging, Carotid Stenosis complications, Carotid Stenosis diagnostic imaging, Carotid Stenosis surgery, Case-Control Studies, Endarterectomy, Carotid, Female, Humans, Longitudinal Studies, Male, Middle Aged, Positron Emission Tomography Computed Tomography, Prospective Studies, Recurrence, Risk Assessment, Risk Factors, Severity of Illness Index, Treatment Outcome, Up-Regulation, Cardiovascular Diseases etiology, Carotid Stenosis blood, Inflammation Mediators blood, Matrix Metalloproteinase 7 blood
- Abstract
Background: Major adverse cardiovascular events are the main cause of morbidity and mortality over the long term in patients undergoing carotid endarterectomy. There are few reports assessing the prognostic value of markers of inflammation in relation to the risk of cardiovascular disease after carotid endarterectomy. Here, we aimed to determine whether matrix metalloproteinases (MMP-1, MMP-2, MMP-7, MMP-9 and MMP-10), tissue inhibitor of MMPs (TIMP-1) and in vivo inflammation studied by
18 F-FDG-PET/CT predict recurrent cardiovascular events in patients with carotid stenosis who underwent endarterectomy., Methods: This prospective cohort study was carried out on 31 consecutive patients with symptomatic (23/31) or asymptomatic (8/31) severe (> 70%) carotid stenosis who were scheduled for carotid endarterectomy between July 2013 and March 2016. In addition, 26 healthy controls were included in the study. Plasma and serum samples were collected 2 days prior to surgery and tested for MMP-1, MMP-2, MMP-7, MMP-9, MMP-10, TIMP-1, high-density lipoprotein, low-density lipoprotein, high-sensitivity C-reactive protein and erythrocyte sedimentation rate.18 F-FDG-PET/CT focusing on several territories' vascular wall metabolism was performed on 29 of the patients because of no presurgical availability in 2 symptomatic patients. Histological and immunohistochemical studies were performed with antibodies targeting MMP-10, MMP-9, TIMP-1 and CD68., Results: The patients with carotid stenosis had significantly more circulating MMP-1, MMP-7 and MMP-10 than the healthy controls. Intraplaque TIMP-1 was correlated with its plasma level (r = 0.42 P = .02) and with18 F-FDG uptake (r = 0.38 P = .05). We did not find any correlation between circulating MMPs and in vivo carotid plaque metabolism assessed by18 F-FDG-PET. After a median follow-up of 1077 days, 4 cerebrovascular, 7 cardiovascular and 11 peripheral vascular events requiring hospitalization were registered. Circulating MMP-7 was capable of predicting events over and above the traditional risk factors (HR = 1.15 P = .006). When the model was associated with the variables of interest, the risk predicted by18 F-FDG-PET was not significant., Conclusions: Circulating MMP-7 may represent a novel marker for recurrent cardiovascular events in patients with moderate to severe carotid stenosis. MMP-7 may reflect the atherosclerotic burden but not plaque inflammation in this specific vascular territory.- Published
- 2020
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17. FDG PET/CT in colorectal cancer.
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Rodríguez-Fraile M, Cózar-Santiago MP, Sabaté-Llobera A, Caresia-Aróztegui AP, Delgado Bolton RC, Orcajo-Rincon J, de Arcocha-Torres M, García-Velloso MJ, and García-Talavera P
- Subjects
- Colonic Neoplasms pathology, Humans, Liver Neoplasms diagnostic imaging, Liver Neoplasms secondary, Liver Neoplasms surgery, Neoplasm Recurrence, Local diagnostic imaging, Neoplasm Staging methods, Practice Guidelines as Topic, Rectal Neoplasms pathology, Colonic Neoplasms diagnostic imaging, Fluorodeoxyglucose F18, Positron Emission Tomography Computed Tomography, Radiopharmaceuticals, Rectal Neoplasms diagnostic imaging
- Abstract
Colorectal cancer is the third most frequent cancer worldwide. Although its incidence is increasing, mainly in those aged under50, mortality has decreased by 50% in the more developed countries, principally due to the adoption of new practices in prevention, diagnosis and treatment. In particular, the various diagnostic imaging modalities allow improved therapeutic decision-making, evaluation of the response and early detection of recurrence. The aim of this paper is to review the available scientific evidence on the value of positron emission tomography with
18 F-FDG (18 F-FDG PET/CT) in the colorectal cancer, with special emphasis on the indications of the guidelines and recommendations of the main international scientific associations regarding this imaging technique., (Copyright © 2019 Sociedad Española de Medicina Nuclear e Imagen Molecular. Publicado por Elsevier España, S.L.U. All rights reserved.)- Published
- 2020
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18. 18 F-FDG PET/CT in locally advanced cervical cancer: A review.
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Caresia-Aróztegui AP, Delgado-Bolton RC, Alvarez-Ruiz S, Del Puig Cózar-Santiago M, Orcajo-Rincon J, de Arcocha-Torres M, and García-Velloso MJ
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- Female, Humans, Lymphatic Metastasis, Neoplasm Staging, Practice Guidelines as Topic, Uterine Cervical Neoplasms pathology, Fluorodeoxyglucose F18, Positron Emission Tomography Computed Tomography methods, Radiopharmaceuticals, Uterine Cervical Neoplasms diagnostic imaging
- Abstract
Cervical cancer is the second most common gynecological cancer worldwide. In locally advanced cervical cancer,
18 F-FDG PET/CT has become important in the initial staging, particularly in the detection of nodal and distant metastasis, aspects with treatment implications and prognostic value. The aims of this study were to review the role of18 F-FDG PET/CT in uterine cervical cancer, according to the guidelines of the main scientific institutions (FIGO, NCCN, SEGO, SEOM, ESGO, and ESMO) and its diagnostic accuracy compared to conventional radiological techniques, as well as to review the acquisition protocol and its utility in radiotherapy planning, response assessment and detection of recurrence., (Copyright © 2018 Sociedad Española de Medicina Nuclear e Imagen Molecular. Publicado por Elsevier España, S.L.U. All rights reserved.)- Published
- 2019
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19. Assessment of metabolic patterns and new antitumoral treatment in osteosarcoma xenograft models by [ 18 F]FDG and sodium [ 18 F]fluoride PET.
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Collantes M, Martínez-Vélez N, Zalacain M, Marrodán L, Ecay M, García-Velloso MJ, Alonso MM, Patiño-García A, and Peñuelas I
- Subjects
- Animals, Cell Line, Tumor, Disease Models, Animal, Female, Humans, Image Processing, Computer-Assisted, Male, Mice, Osteosarcoma pathology, Osteosarcoma therapy, Radiopharmaceuticals, Energy Metabolism, Fluorine Radioisotopes, Fluorodeoxyglucose F18, Osteosarcoma diagnostic imaging, Osteosarcoma metabolism, Positron-Emission Tomography
- Abstract
Background: Osteosarcoma is the most common malignant bone tumor in children and young adults that produces aberrant osteoid. The aim of this study was to assess the utility of 2-deoxy-2-[18F-] fluoro-D-glucose ([
18 F] FDG) and sodium [18 F] Fluoride (Na [18 F] F) PET scans in orthotopic murine models of osteosarcoma to describe the metabolic pattern of the tumors, to detect and diagnose tumors and to evaluate the efficacy of a new treatment based in oncolytic adenoviruses., Methods: Orthotopic osteosarcoma murine models were created by the injection of 143B and 531MII cell lines. [18 F]FDG and Na [18 F] F PET scans were performed 30 days (143B) and 90 days (531MII) post-injection. The antitumor effect of two doses (107 and 108 pfu) of the oncolytic adenovirus VCN-01 was evaluated in 531 MII model by [18 F] FDG PET studies. [18 F] FDG uptake was quantified by SUVmax and Total Lesion Glycolysis (TLG) indexes. For Na [18 F] F, the ratio tumor SUVmax/hip SUVmax was calculated. PET findings were confirmed by histopathological techniques., Results: The metabolic pattern of tumors was different between both orthotopic models. All tumors showed [18 F] FDG uptake, with a sensitivity and specificity of 100%. The [18 F] FDG uptake was significantly higher for the 143B model (p < 0.001). Sensitivity for Na [18 F] F was around 70% in both models, with a specificity of 100%. 531MII tumors showed a heterogeneous Na [18 F] F uptake, significantly higher than 143B tumors (p < 0.01). Importantly, [18 F] FDG and Na [18 F] F uptake corresponded to highly cellular or osteoid-rich tumors in the histopathological analysis, respectively. [18 F] FDG data confirmed that the oncolytic treatment of 531MII tumors produced a significant reduction in growth even with the 107 pfu dose., Conclusions: PET studies demonstrated that the different osteosarcoma xenograft models developed tumors with diverse metabolic patterns that can be described by multitracer PET studies. Since not all tumors produced abundant osteoid, [18 F] FDG demonstrated a better sensitivity for tumor detection and was able to quantitatively monitor in vivo response to the oncolytic adenovirus VCN-01.- Published
- 2018
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20. Radium-223 in the treatment of bone metastasis in patients with castration-resistant prostate cancer. Review and procedure.
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Orcajo-Rincon J, Caresia-Aróztegui AP, Del Puig Cózar-Santiago M, García-Garzón JR, de Arcocha-Torres M, Delgado-Bolton RC, García-Velloso MJ, Alvarez-Ruiz S, and García-Vicente AM
- Subjects
- Bone Neoplasms secondary, Humans, Male, Radiotherapy Dosage, Bone Neoplasms radiotherapy, Prostatic Neoplasms, Castration-Resistant pathology, Radium therapeutic use
- Abstract
Bone metastatic disease is the main cause of morbidity / mortality in patients with prostate cancer, presenting frequently as bone pain, pathological fractures or spinal cord compression, which requires early and timely therapy. Although, for the moment, the therapeutic window for its use has not been definitively established, radium-223 (
223 Ra), an alpha particle emitter, has proved to be an effective therapeutic tool, pre or post-chemotherapy, in patients with castration-resistant prostate cancer with symptomatic bone metastases and absence of visceral metastases, significantly modifying the prognosis of the disease. It is therefore imperative to define the ideal scenarios and the correct protocol for the use of this therapy and thus offer the greatest possible clinical benefit to the patient., (Copyright © 2018 Sociedad Española de Medicina Nuclear e Imagen Molecular. Publicado por Elsevier España, S.L.U. All rights reserved.)- Published
- 2018
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21. 68 Ga-PSMA PET/CT in prostate cancer.
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García Garzón JR, de Arcocha Torres M, Delgado-Bolton R, Ceci F, Alvarez Ruiz S, Orcajo Rincón J, Caresia Aróztegui AP, García Velloso MJ, and García Vicente AM
- Subjects
- Adenocarcinoma chemistry, Adenocarcinoma pathology, Adenocarcinoma therapy, Aged, Edetic Acid chemical synthesis, Edetic Acid pharmacokinetics, Follow-Up Studies, Gallium Isotopes, Gene Expression Regulation, Neoplastic, Humans, Male, Middle Aged, Neoplasm Staging, Oligopeptides chemical synthesis, Prognosis, Prostate-Specific Antigen analysis, Prostate-Specific Antigen biosynthesis, Prostate-Specific Antigen genetics, Prostatic Neoplasms chemistry, Prostatic Neoplasms pathology, Prostatic Neoplasms therapy, Radiometry, Radiopharmaceuticals chemical synthesis, Recurrence, Sensitivity and Specificity, Tissue Distribution, Tumor Burden, Adenocarcinoma diagnostic imaging, Edetic Acid analogs & derivatives, Gallium Radioisotopes pharmacokinetics, Oligopeptides pharmacokinetics, Positron Emission Tomography Computed Tomography methods, Prostatic Neoplasms diagnostic imaging, Radiopharmaceuticals pharmacokinetics
- Abstract
Positron emission tomography/computed tomography (PET/CT) with
68 Ga-PSMA is a non-invasive diagnostic technique to image prostate cancer with increased prostate-specific membrane antigen (PSMA) expression. PSMA is a transmembrane protein present in all prostatic tissues. Increased PSMA expression is seen in several malignancies, although prostate cancer is the tumour where it presents higher concentrations. Almost all prostate adenocarcinomas show PSMA expression in most of lesions, primary and metastatic. Immunohistochemistry has demonstrated that the expression of PSMA increases in patients with de-differentiated, metastatic or hormone-refractory tumours. Moreover, the expression level of PSMA has a prognostic value for disease outcome. PET measures the three-dimensional distribution of68 Ga-PSMA, producing semi-quantitative images that allow for non-invasive assessment of PSMA expression., (Copyright © 2017 Elsevier España, S.L.U. y SEMNIM. All rights reserved.)- Published
- 2018
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22. Evolution of Nuclear Medicine in the diagnosis and treatment of prostate cancer.
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García Velloso MJ and Rodríguez Fraile M
- Subjects
- Humans, Male, Radionuclide Imaging, Nuclear Medicine, Prostatic Neoplasms
- Published
- 2018
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23. Significant dose reduction is feasible in FDG PET/CT protocols without compromising diagnostic quality.
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Prieto E, García-Velloso MJ, Rodríguez-Fraile M, Morán V, García-García B, Guillén F, Morales MI, Sancho L, Peñuelas I, Richter JÁ, and Martí-Climent JM
- Subjects
- Feasibility Studies, Female, Humans, Male, Middle Aged, Quality Control, Fluorodeoxyglucose F18, Positron Emission Tomography Computed Tomography, Radiation Dosage
- Abstract
Purpose: To reduce the radiation dose to patients by optimizing oncological FDG PET/CT protocols., Methods: The baseline PET/CT protocol in our institution for oncological PET/CT examinations consisted of the administration of 5.18 MBq/kg of FDG and a CT acquisition with a reference current-time product of 120 mAs. In 2016, FDG activity was reduced to 4.44 and 3.70 MBq/kg and reference CT current-time-product was reduced to 100 and 80 mAs. 322 patients scanned with different protocols were retrospectively evaluated. For each patient, effective dose was calculated. The overall image quality was subjectively rated by the referring physician on a 4-point scale (IQ score: 1 excellent, 2 good, 3 poor but interpretable, 4 poor not interpretable). Image quality was quantitatively evaluated measuring noise in the liver., Results: CT Results: Effective dose was progressively reduced from 9.5 ± 2.8 to 8.0 ± 2.3 and 6.2 ± 1.5 mSv (p < 0.001). A mean dose reduction of 34.9% was achieved. There was a significant degradation of IQ score (p < 0.05) and noise (p < 0.001). Nevertheless, the number of poor quality studies (IQ score >2) did not increase. PET Results: Effective dose was gradually reduced from 6.5 ± 1.4 to 5.7 ± 1.3 and 5.0 ± 1.0 mSv (p < 0.001). Average dose reduction was 23.4%. IQ score (p < 0.05) and noise (p < 0.001) significantly degraded for lower activity protocols. However, all images with reduced activity were scored as interpretable (IQ score ≤ 3)., Conclusions: A significant radiation dose reduction of 28.7% was reached. Despite a slight reduction in image quality, the new regime was successfully implemented with readers reporting unchanged clinical confidence., (Copyright © 2018 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2018
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24. Effective dose estimation for oncological and neurological PET/CT procedures.
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Martí-Climent JM, Prieto E, Morán V, Sancho L, Rodríguez-Fraile M, Arbizu J, García-Velloso MJ, and Richter JA
- Abstract
Background: The aim of this study was to retrospectively evaluate the patient effective dose (ED) for different PET/CT procedures performed with a variety of PET radiopharmaceutical compounds. PET/CT studies of 210 patients were reviewed including Torso (n = 123), Whole body (WB) (n = 36), Head and Neck Tumor (HNT) (n = 10), and Brain (n = 41) protocols with
18 FDG (n = 170),11 C-CHOL (n = 10),18 FDOPA (n = 10),11 C-MET (n = 10), and18 F-florbetapir (n = 10). ED was calculated using conversion factors applied to the radiotracer activity and to the CT dose-length product., Results: Total ED (mean ± SD) for Torso-11 C-CHOL, Torso-18 FDG, WB-18 FDG, and HNT-18 FDG protocols were 13.5 ± 2.2, 16.5 ± 4.5, 20.0 ± 5.6, and 15.4 ± 2.8 mSv, respectively, where CT represented 77, 62, 69, and 63% of the protocol ED, respectively. For18 FDG,18 FDOPA,11 C-MET, and18 F-florbetapir brain PET/CT studies, ED values (mean ± SD) were 6.4 ± 0.6, 4.6 ± 0.4, 5.2 ± 0.5, and 9.1 ± 0.4 mSv, respectively, and the corresponding CT contributions were 11, 14, 23, and 26%, respectively. In18 FDG PET/CT, variations in scan length and arm position produced significant differences in CT ED (p < 0.01). For dual-time-point imaging, the CT ED (mean ± SD) for the delayed scan was 3.8 ± 1.5 mSv., Conclusions: The mean ED for body and brain PET/CT protocols with different radiopharmaceuticals ranged between 4.6 and 20.0 mSv. The major contributor to total ED for body protocols is CT, whereas for brain studies, it is the PET radiopharmaceutical.- Published
- 2017
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25. 18 F-fluorodeoxyglucose positron emission tomography in the diagnosis of malignancy in patients with paraneoplastic neurological syndrome: a systematic review and meta-analysis.
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García Vicente AM, Delgado-Bolton RC, Amo-Salas M, López-Fidalgo J, Caresia Aróztegui AP, García Garzón JR, Orcajo Rincón J, García Velloso MJ, de Arcocha Torres M, and Alvárez Ruíz S
- Subjects
- Humans, Fluorodeoxyglucose F18, Paraneoplastic Syndromes, Nervous System diagnostic imaging, Positron-Emission Tomography methods
- Abstract
Purpose: The detection of occult cancer in patients suspected of having a paraneoplastic neurological syndrome (PNS) poses a diagnostic challenge. The aim of our study was to perform a systematic review and meta-analysis to assess the diagnostic performance of FDG PET for the detection of occult malignant disease responsible for PNS., Methods: A systematic review of the literature (MEDLINE, EMBASE, Cochrane, and DARE) was undertaken to identify studies published in any language. The search strategy was structured after addressing clinical questions regarding the validity or usefulness of the test, following the PICO framework. Inclusion criteria were studies involving patients with PNS in whom FDG PET was performed to detect malignancy, and which reported sufficient primary data to allow calculation of diagnostic accuracy parameters. When possible, a meta-analysis was performed to calculate the joint sensitivity, specificity, and detection rate for malignancy (with 95% confidence intervals [CIs]), as well as a subgroup analysis based on patient characteristics (antibodies, syndrome)., Results: The comprehensive literature search revealed 700 references. Sixteen studies met the inclusion criteria and were ultimately selected. Most of the studies were retrospective (12/16). For the quality assessment, the QUADAS-2 tool was applied to assess the risk of bias. Across 16 studies (793 patients), the joint sensitivity, specificity, and detection rate for malignancy with FDG PET were 0.87 (95% CI: 0.80-0.93), 0.86 (95% CI: 0.83-0.89), and 14.9% (95% CI: 11.5-18.7), respectively. The area under the curve (AUC) of the summary ROC curve was 0.917. Homogeneity of results was observed for sensitivity but not for specificity. Some of the individual studies showed large 95% CIs as a result of small sample size., Conclusions: The results of our meta-analysis reveal high diagnostic performance of FDG PET in the detection of malignancy responsible for PNS, not affected by the presence of onconeural antibodies or clinical characteristics.
- Published
- 2017
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26. Non-invasive in vivo imaging of cardiac stem/progenitor cell biodistribution and retention after intracoronary and intramyocardial delivery in a swine model of chronic ischemia reperfusion injury.
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Collantes M, Pelacho B, García-Velloso MJ, Gavira JJ, Abizanda G, Palacios I, Rodriguez-Borlado L, Álvarez V, Prieto E, Ecay M, Larequi E, Peñuelas I, and Prósper F
- Subjects
- Animals, Cell Separation, Disease Models, Animal, Female, Fluorodeoxyglucose F18 chemistry, Glucosamine analogs & derivatives, Glucosamine chemistry, Myocardial Reperfusion Injury diagnostic imaging, Myocardial Reperfusion Injury pathology, Positron Emission Tomography Computed Tomography, Sus scrofa, Tissue Distribution, Diagnostic Imaging methods, Injections, Myocardial Reperfusion Injury therapy, Myocardium pathology, Stem Cell Transplantation, Stem Cells cytology
- Abstract
Background: The safety and efficacy of cardiac stem/progenitor cells (CSC) have been demonstrated in previous preclinical and clinical assays for heart failure. However, their optimal delivery route to the ischemic heart has not yet been assessed. This study was designed to determine by a non-invasive imaging technique (PET/CT) the biodistribution and acute retention of allogeneic pig CSC implanted by two different delivery routes, intracoronary (IC) and intramyocardial (IM), in a swine preclinical model of chronic ischemia-reperfusion., Methods: Ischemia-reperfusion was induced in six Goettingen hybrid minipigs by 90 min coronary artery occlusion followed by reperfusion. Thirty days later, animals were allocated to receive IC (n = 3) or NOGA
® -guided IM injection (n = 3) of 50 million of18 F-FDG/GFP-labeled allogeneic pig CSC. Acute retention was quantified by PET/CT 4 h after injection and cell engraftment assessed by immunohistochemical quantification of GFP+ cells three days post-injection., Results: Biodistribution of18 F-FDG-labeled CSC was clearly visualized by PET/CT imaging and quantified. No statistical differences in acute cell retention (percentage of injected dose, %ID) were found in the heart when cells were administered by NOGA® -guided IM (13.4 ± 3.4%ID) or IC injections (17.4 ± 4.1%ID). Interestingly, engrafted CSC were histologically detected only after IM injection., Conclusion: PET/CT imaging of18 F-FDG-labeled CSC allows quantifying biodistribution and acute retention of implanted cells in a clinically relevant pig model of chronic myocardial infarction. Similar levels of acute retention are achieved when cells are IM or IC administered. However, acute cell retention does not correlate with cell engraftment, which is improved by IM injection.- Published
- 2017
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27. Lung cancer screening: fourteen year experience of the Pamplona early detection program (P-IELCAP).
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Sanchez-Salcedo P, Berto J, de-Torres JP, Campo A, Alcaide AB, Bastarrika G, Pueyo JC, Villanueva A, Echeveste JI, Lozano MD, García-Velloso MJ, Seijo LM, García J, Torre W, Pajares MJ, Pío R, Montuenga LM, and Zulueta JJ
- Subjects
- Adenocarcinoma diagnostic imaging, Adenocarcinoma epidemiology, Adult, Aged, Carcinoma, Non-Small-Cell Lung diagnostic imaging, Carcinoma, Non-Small-Cell Lung epidemiology, Feasibility Studies, Female, Humans, Incidence, Kaplan-Meier Estimate, Lung Neoplasms epidemiology, Male, Middle Aged, Prevalence, Program Evaluation, Proportional Hazards Models, Pulmonary Disease, Chronic Obstructive epidemiology, Pulmonary Emphysema epidemiology, Risk, Smoking adverse effects, Spain epidemiology, Spirometry, Survival Rate, Early Detection of Cancer, Lung Neoplasms diagnostic imaging, Tomography, X-Ray Computed methods
- Abstract
Introduction and Objectives: European experience regarding lung cancer screening using low-dose chest CT (LDCT) is available. However, there is limited data on the Spanish experience in this matter. Our aim is to present the results from the longest ongoing screening program in Spain., Methodology: The Pamplona International Early Lung Cancer Detection Program (P-IELCAP) is actively screening participants for lung cancer using LDCT since year 2000 following the IELCAP protocol, including spirometric assessments. Men and women, ≥40 years of age, current or former smokers with a tobacco history of ≥10 pack-years are included. Results are compared to those from other European trials., Results: A total of 2989 participants were screened until March 2014 (73% male). A median of 2 (IQR 1-3) annual screening rounds were performed. Sixty lung cancers were detected in 53 participants (73% in StageI). Adenocarcinoma was the most frequent. The lung cancer prevalence and incidence proportion was 1.0% and 1.4%, respectively, with an annual detection rate of 0.41. The estimated 10-year survival rate among individuals with lung cancer was 70%. Chronic obstructive pulmonary disease and emphysema are important lung cancer predictors., Conclusions: The experience in Spain's longest lung cancer screening program is comparable to what has been described in the rest of Europe, and confirms the feasibility and efficacy of lung cancer screening using LDCT., (Copyright © 2014 SEPAR. Published by Elsevier Espana. All rights reserved.)
- Published
- 2015
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28. Impact of initial FDG PET/CT in the management plan of patients with locally advanced head and neck cancer.
- Author
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Arias F, Chicata V, García-Velloso MJ, Asín G, Uzcanga M, Eito C, Quilez I, Viudez A, Saenz J, Hernández I, Caicedo C, Errasti M, Barrado M, and García-Bragado F
- Subjects
- Adult, Aged, Aged, 80 and over, Disease Management, Female, Follow-Up Studies, Humans, Male, Middle Aged, Multimodal Imaging methods, Neoplasm Staging, Prognosis, Radiopharmaceuticals, Retrospective Studies, Carcinoma, Squamous Cell diagnostic imaging, Carcinoma, Squamous Cell secondary, Fluorodeoxyglucose F18, Head and Neck Neoplasms diagnostic imaging, Head and Neck Neoplasms pathology, Positron-Emission Tomography methods, Tomography, X-Ray Computed methods
- Abstract
Objective: To determine the impact of initial FDG PET/CT staging on clinical stage and the management plan in patients with locally advanced head and neck cancer (LAHNC)., Materials and Methods: We retrospectively reviewed the records of 72 consecutive patients (2007-2010) staged with PET/CT and conventional CT with tumours of hypopharynx/larynx (26 patients, 36 %), oral cavity (17 patients, 24 %), oropharynx (16 patients, 22 %), nasopharynx (12 patients, 17 %), and others (2 %). The impact of PET/CT on management plans was considered high when PET/CT changed the planned treatment modality or treatment intent, and intramodality changes were considered as minor changes with low impact., Results: FDG PET/CT changed the stage in 27 patients and had high impact on the management plan in 12 % of patients (detection of distant metastases in 6 patients and stage II in 2 patients). Intramodality changes were more frequent: FDG PET/CT altered the TNM stage in 18/72 (25 %) of patients, upstaging N stage in 90 % of patients with low impact., Conclusions: Initial FDG PET/CT staging not only improves stage but also affects the management plan in LAHNC patients.
- Published
- 2015
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29. PET optimization for improved assessment and accurate quantification of 90Y-microsphere biodistribution after radioembolization.
- Author
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Martí-Climent JM, Prieto E, Elosúa C, Rodríguez-Fraile M, Domínguez-Prado I, Vigil C, García-Velloso MJ, Arbizu J, Peñuelas I, and Richter JA
- Subjects
- Adenocarcinoma diagnostic imaging, Adenocarcinoma metabolism, Adenocarcinoma therapy, Aged, Carcinoma, Hepatocellular diagnostic imaging, Carcinoma, Hepatocellular metabolism, Carcinoma, Hepatocellular therapy, Cholangiocarcinoma diagnostic imaging, Cholangiocarcinoma metabolism, Cholangiocarcinoma therapy, Colorectal Neoplasms diagnostic imaging, Colorectal Neoplasms metabolism, Colorectal Neoplasms therapy, Computer Simulation, Esophageal Neoplasms diagnostic imaging, Esophageal Neoplasms metabolism, Esophageal Neoplasms therapy, Humans, Liver diagnostic imaging, Liver metabolism, Liver Neoplasms diagnostic imaging, Liver Neoplasms metabolism, Liver Neoplasms therapy, Male, Middle Aged, Neuroendocrine Tumors diagnostic imaging, Neuroendocrine Tumors metabolism, Neuroendocrine Tumors therapy, Phantoms, Imaging, Positron-Emission Tomography instrumentation, Radiation Dosage, Signal-To-Noise Ratio, Tissue Distribution, Yttrium Radioisotopes therapeutic use, Brachytherapy, Embolization, Therapeutic, Microspheres, Positron-Emission Tomography methods, Yttrium Radioisotopes pharmacokinetics
- Abstract
Purpose: 90Y-microspheres are widely used for the radioembolization of metastatic liver cancer or hepatocellular carcinoma and there is a growing interest for imaging 90Y-microspheres with PET. The aim of this study is to evaluate the performance of a current generation PET/CT scanner for 90Y imaging and to optimize the PET protocol to improve the assessment and the quantification of 90Y-microsphere biodistribution after radioembolization., Methods: Data were acquired on a Biograph mCT-TrueV scanner with time of flight (TOF) and point spread function (PSF) modeling. Spatial resolution was measured with a 90Y point source. Sensitivity was evaluated using the NEMA 70 cm line source filled with 90Y. To evaluate the count rate performance, 90Y vials with activity ranging from 3.64 to 0.035 GBq were measured in the center of the field of view (CFOV). The energy spectrum was evaluated. Image quality with different reconstructions was studied using the Jaszczak phantom containing six hollow spheres (diameters: 31.3, 28.1, 21.8, 16.1, 13.3, and 10.5 mm), filled with a 207 kBq/ml 90Y concentration and a 5:1 sphere-to-background ratio. Acquisition time was adjusted to simulate the quality of a realistic clinical PET acquisition of a patient treated with SIR-Spheres®. The developed methodology was applied to ten patients after SIR-Spheres® treatment acquiring a 10 min per bed PET., Results: The energy spectrum showed the 90Y bremsstrahlung radiation. The 90Y transverse resolution, with filtered backprojection reconstruction, was 4.5 mm in the CFOV and degraded to 5.0 mm at 10 cm off-axis. 90Y absolute sensitivity was 0.40 kcps/MBq in the center of the field of view. Tendency of true and random rates as a function of the 90Y activity could be accurately described using linear and quadratic models, respectively. Phantom studies demonstrated that, due to low count statistics in 90Y PET acquisition, the optimal parameters for the standard OSEM+PSF reconstruction were only one iteration and a postreconstruction filter of 6 mm FWHM, for both TOF and non-TOF reconstructions. Moreover, when TOF is included, the signal to noise ratio increased and visibility achieved 100% by the experienced observers and 93.3% according to the Rose model of statistical detection. In 50% of patients, TOF allowed the visualization of 90Y radioembolized lesions not seen without TOF, confirming phantom results. Liver activity was accurately quantified, with no significant differences between reconstructed and actual delivered activity to the whole-liver [mean relative difference (10.2±14.7)%]., Conclusions: Qualitative and quantitative 90Y PET imaging improved with the introduction of TOF in a PET/CT scanner, thereby allowing the visualization of microsphere deposition in lesions not visible in non-TOF images. This technique accurately quantifies the total activity delivered to the liver during radioembolization with (90)Y-microspheres and allows dose estimation.
- Published
- 2014
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30. [Validation of segmentation techniques for positron emission tomography using ex-vivo images of oncological surgical specimens].
- Author
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Prieto E, Martí-Climent JM, Gómez-Fernández M, García-Velloso MJ, Valero M, Garrastachu P, Aristu J, Alcázar JL, Torre W, Hernández JL, Pardo FJ, Peñuelas I, and Richter JA
- Subjects
- Aged, Aged, 80 and over, Algorithms, Breast Neoplasms surgery, Colorectal Neoplasms surgery, Female, Humans, Male, Middle Aged, Prostatic Neoplasms surgery, Breast Neoplasms diagnostic imaging, Colorectal Neoplasms diagnostic imaging, Positron-Emission Tomography methods, Prostatic Neoplasms diagnostic imaging
- Abstract
Objective: To design a novel ex-vivo acquisition technique to establish a common framework to validate different segmentation techniques for oncological PET images. To evaluate several automatic segmentation algorithms on this set of images., Material and Methods: In 15 patients with cancer, ex-vivo PET studies of surgical specimens removed during surgery were performed after injection of (18)F-FDG. Images were acquired in two scanners: a clinical PET/CT and a high-resolution PET scanner. Real tumor volume was determined in each patient, and a reference image was generated for segmentation of each tumor. Images were segmented with 12 automatic algorithms and with a standard method for PET (relative threshold at 42%) and results were evaluated by quantitative parameters., Results: It has been possible to demonstrate by segmentation of PET images of surgical specimens that on high resolution PET images, 8 out of 12 evaluated segmentation techniques outperformed the standard method, whose value is 42%. However, none of the algorithms outperformed the standard method when applied on images from the clinical PET/CT. Due to the great interest of this set of PET images, all studies have been published on the Internet in order to provide a common framework for validation and comparison of different segmentation techniques., Conclusions: We have proposed a novel technique to validate segmentation techniques for oncological PET images, acquiring ex-vivo PET studies of surgical specimens. We have demonstrated the usefulness of this set of PET images by evaluating several automatic segmentation algorithms., (Copyright © 2013 Elsevier España, S.L. and SEMNIM. All rights reserved.)
- Published
- 2014
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31. Functional imaging in radiation therapy planning for head and neck cancer.
- Author
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Pérez Romasanta LA, García Velloso MJ, and López Medina A
- Abstract
Functional imaging and its application to radiotherapy (RT) is a rapidly expanding field with new modalities and techniques constantly developing and evolving. As technologies improve, it will be important to pay attention to their implementation. This review describes the main achievements in the field of head and neck cancer (HNC) with particular remarks on the unsolved problems.
- Published
- 2013
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32. Screening for occult malignancy with FDG-PET/CT in patients with unprovoked venous thromboembolism.
- Author
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Alfonso A, Redondo M, Rubio T, Del Olmo B, Rodríguez-Wilhelmi P, García-Velloso MJ, Richter JA, Páramo JA, and Lecumberri R
- Subjects
- Aged, Anticoagulants therapeutic use, Biomarkers, Tumor blood, Female, Follow-Up Studies, Humans, Male, Neoplasms, Unknown Primary etiology, Neoplasms, Unknown Primary metabolism, Prognosis, Prospective Studies, Radiopharmaceuticals, Venous Thromboembolism drug therapy, Blood Coagulation Factors analysis, Early Detection of Cancer, Fluorodeoxyglucose F18, Neoplasms, Unknown Primary diagnosis, Positron-Emission Tomography, Tomography, X-Ray Computed, Venous Thromboembolism complications
- Abstract
Extensive screening strategies to detect occult cancer in patients with unprovoked venous thromboembolism (VTE) are complex and no benefit in terms of survival has been reported. FDG-PET/CT (2-[F-18] fluoro-2-deoxy-D-glucose positron emission tomography combined with computed tomography), a noninvasive technique for the diagnosis and staging of malignancies, could be useful in this setting. Consecutive patients ≥ 50 years with a first unprovoked VTE episode were prospectively included. Screening with FDG-PET/CT was performed 3-4 weeks after the index event. If positive, appropriate diagnostic work-up was programmed. Clinical follow-up continued for 2 years. Blood samples were collected to assess coagulation biomarkers. FDG-PET/CT was negative in 68/99 patients (68.7%), while suspicious FDG uptake was detected in 31/99 patients (31.3%). Additional diagnostic work-up confirmed a malignancy in 7/31 patients (22.6%), with six of them at early stage. During follow-up, two patients with negative FDG-PET/CT were diagnosed with cancer. Sensitivity (S), positive (PPV) and negative predictive values (NPV) of FDG-PET/CT as single tool for the detection of occult malignancy were 77.8% (95% CI: 0.51-1), 22.6% (95% CI: 0.08-0.37) and 97.1% (95% CI: 0.93-1), respectively. Median tissue factor (TF) activity in patients with occult cancer was 5.38 pM vs. 2.40 pM in those without cancer (p = 0.03). Limitation of FDG-PET/CT screening to patients with TF activity > 2.8 pM would improve the PPV to 37.5% and reduce the costs of a single cancer diagnosis from 20,711€ to 11,670€. FDG-PET/CT is feasible for the screening of occult cancer in patients with unprovoked VTE, showing high S and NPV. The addition of TF activity determination may be useful for patient selection., (Copyright © 2013 UICC.)
- Published
- 2013
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33. Impact of time-of-flight and point-spread-function in SUV quantification for oncological PET.
- Author
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Prieto E, Domínguez-Prado I, García-Velloso MJ, Peñuelas I, Richter JÁ, and Martí-Climent JM
- Subjects
- Biological Transport, Breast Neoplasms metabolism, Humans, Lung Neoplasms metabolism, Phantoms, Imaging, Time Factors, Whole Body Imaging, Breast Neoplasms diagnostic imaging, Image Processing, Computer-Assisted methods, Lung Neoplasms diagnostic imaging, Multimodal Imaging methods, Positron-Emission Tomography, Tomography, X-Ray Computed
- Abstract
Background: Accuracy in the quantification of the SUV is a critical point in PET because proper quantification of tumor uptake is essential for therapy monitoring and prognosis evaluation. Recent advances such as time-of-flight (TOF) and point-spread-function (PSF) reconstructions have dramatically improved detectability. However, first experiences with these techniques have shown a consistent tendency to measure markedly high SUV values, bewildering nuclear medicine physicians and referring clinicians., Purpose: We investigated different reconstruction and quantification procedures to determine the optimum protocol for an accurate SUV quantification in last generation PET scanners., Methods: Both phantom and patient images were evaluated. A complete set of experiments was performed using a body phantom containing 6 spheres with different background levels and contrasts. Whole-body FDG PET/CT of 20 patients with breast and lung cancer was evaluated. One hundred five foci were identified by 2 experienced nuclear medicine physicians.Each acquisition was reconstructed both with classical and advanced (TOF, PSF) reconstruction techniques. Each sphere and each in vivo lesion was quantified with different parameters as follows: SUV(max), SUV(mean), and SUV(50) (mean within a 50% isocontour)., Results: This study has confirmed that quantification with SUV(max) produces important overestimation of metabolism in new generation PET scanners. This is a relevant result because, currently, SUV(max) is the standard parameter for quantification. SUV(50) has been shown as the best alternative, especially when applied to images reconstructed with PSF + TOF., Conclusions: SUV(50) provides accurate quantification and should replace SUV(max) in PET tomographs incorporating advanced reconstruction techniques. PSF + TOF reconstruction is the optimum for both detection and accurate quantification.
- Published
- 2013
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34. [Contribution of time of flight and point spread function modeling to the performance characteristics of the PET/CT Biograph mCT scanner].
- Author
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Martí-Climent JM, Prieto E, Domínguez-Prado I, García-Velloso MJ, Rodríguez-Fraile M, Arbizu J, Vigil C, Caicedo C, Peñuelas I, and Richter JA
- Subjects
- Equipment Design, Multimodal Imaging methods, Positron-Emission Tomography methods, Tomography, X-Ray Computed methods, Computer Simulation, Multimodal Imaging instrumentation, Positron-Emission Tomography instrumentation, Tomography, X-Ray Computed instrumentation
- Abstract
Objective: To characterize the performance of the Biograph mCT PET/CT TrueV scanner with time of flight (TOF) and point spread function (PSF) modeling., Material and Methods: The PET/CT scanner combines a 64-slice CT and PET scanner that incorporates in the reconstruction the TOF and PSF information. PET operating characteristics were evaluated according to the standard NEMA NU 2-2007, expanding some tests. In addition, different reconstruction algorithms were included, and the intrinsic radiation and tomographic uniformity were also evaluated., Results: The spatial resolution (FWHM) at 1 and 10cm was 4.4 and 5.3mm, improving to 2.6 and 2.5mm when PSF is introduced. Sensitivity was 10.9 and 10.2 Kcps/MBq at 0 and 10cm from the axis. Scatter fraction was less than 34% at low concentrations and the noise equivalent count rate (NECR) was maximal at 27.8 kBq/mL with 182 Kcps, the intrinsic radiation produced a rate of 4.42 true coincidences per second. Coefficient of variation of the volume and system uniformity were 4.7 and 0.8% respectively. The image quality test showed better results when PSF and TOF were included together. PSF improved the hot spheres contrast and background variability, while TOF improved the cold spheres contrast., Conclusions: The Biograph mCT TrueV scanner has good performance characteristics. The image quality improves when the information from the PSF and the TOF is incorporated in the reconstruction., (Copyright © 2012 Elsevier España, S.L. y SEMNIM. All rights reserved.)
- Published
- 2013
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35. PET Tracers for Clinical Imaging of Breast Cancer.
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Peñuelas I, Domínguez-Prado I, García-Velloso MJ, Martí-Climent JM, Rodríguez-Fraile M, Caicedo C, Sánchez-Martínez M, and Richter JA
- Abstract
Molecular imaging of breast cancer has undoubtedly permitted a substantial development of the overall diagnostic accuracy of this malignancy in the last years. Accurate tumour staging, design of individually suited therapies, response evaluation, early detection of recurrence and distant lesions have also evolved in parallel with the development of novel molecular imaging approaches. In this context, positron emission tomography (PET) can be probably seen as the most interesting molecular imaging technology with straightforward clinical application for such purposes. Dozens of radiotracers for PET imaging of breast cancer have been tested in laboratory animals. However, in this review we shall focus mainly in the smaller group of PET radiopharmaceuticals that have lead through into the clinical setting. PET imaging can be used to target general metabolic phenomena related to tumoural transformation, including glucose metabolism and cell proliferation, but can also be directed to specific hormone receptors that are characteristic of the breast cancer cell. Many other receptors and transport molecules present in the tumour cells could also be of interest for imaging. Furthermore, molecules related with the tumour microenvironment, tumour induced angiogenesis or even hypoxia could also be used as molecular biomarkers for breast cancer imaging.
- Published
- 2012
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36. [Identification of the lymph node drainage and selective sentinel lymph node biopsy in a patient with amelanotic melanoma of the uvula].
- Author
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Domínguez-Prado I, Rodríguez-Fraile M, Alcalde JM, de Abajo J, Martín-Algarra S, and García-Velloso MJ
- Subjects
- Fluorine Radioisotopes, Fluorodeoxyglucose F18, Humans, Male, Melanoma, Amelanotic diagnostic imaging, Melanoma, Amelanotic surgery, Middle Aged, Neck Dissection, Palatal Neoplasms surgery, Radiopharmaceuticals, Uvula surgery, Lymphatic Metastasis diagnostic imaging, Lymphatic Vessels diagnostic imaging, Melanoma, Amelanotic secondary, Multimodal Imaging, Palatal Neoplasms pathology, Positron-Emission Tomography, Sentinel Lymph Node Biopsy, Tomography, X-Ray Computed, Uvula pathology
- Published
- 2011
- Full Text
- View/download PDF
37. Dual tracer 11C-choline and FDG-PET in the diagnosis of biochemical prostate cancer relapse after radical treatment.
- Author
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Richter JA, Rodríguez M, Rioja J, Peñuelas I, Martí-Climent J, Garrastachu P, Quincoces G, Zudaire J, and García-Velloso MJ
- Subjects
- Adult, Aged, Carbon Radioisotopes, Humans, Male, Middle Aged, Prostatic Neoplasms blood, Choline, Fluorodeoxyglucose F18, Neoplasm Recurrence, Local diagnostic imaging, Positron-Emission Tomography, Prostate-Specific Antigen blood, Prostatic Neoplasms diagnostic imaging, Prostatic Neoplasms therapy
- Abstract
Purpose: The purpose of this study was to evaluate a dual tracer 2-deoxy-2-[F-18]fluoro-D: -glucose (FDG) and (11)C-choline positron emission tomography (PET) protocol in the detection of biochemical prostate cancer relapse., Procedures: Seventy-three patients (median Prostate Specific Antigen (PSA) Test value 2.7 ng/ml (1.1-5.4)) after radical treatment. PET scans were performed by means of a ECAT-Exact HR+ in the first 18 patients and in a PET/computed tomography Biograph II in the remaining 55 patients., Results: The sensitivity of (11)C-choline and FDG was 60.6% and 31%. In PSA levels over 1.9 ng/ml, sensitivity increased to 80% and 40%, respectively. In the group receiving adjuvant hormone therapy, the diagnostic yields were 71.2% and 43%, respectively. While (11)C-choline-PET could not differentiate well and poorly differentiated Gleason score patients, FDG-PET results were almost significant (p = 0.058)., Conclusions: A PSA value higher than 1.9 ng/ml determines a significant increase in the diagnostic yield. Adjuvant hormonotherapy has no influence on the PET results. FDG has a better correlation with the Gleason score than (11)C-choline.
- Published
- 2010
- Full Text
- View/download PDF
38. Evaluation of spatial resolution of a PET scanner through the simulation and experimental measurement of the recovery coefficient.
- Author
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Prieto E, Martí-Climent JM, Arbizu J, Garrastachu P, Domínguez I, Quincoces G, García-Velloso MJ, Lecumberri P, Gómez-Fernández M, and Richter JA
- Subjects
- Brain diagnostic imaging, Fluorine Radioisotopes, Humans, Image Enhancement instrumentation, Image Processing, Computer-Assisted, Computer Simulation, Image Enhancement methods, Positron-Emission Tomography
- Abstract
Purpose: In order to measure spatial resolution of a PET tomograph in clinical conditions, this study describes and validates a method based on the recovery coefficient, a factor required to compensate underestimation in measured radioactivity concentration for small structures., Methods: In a PET image, the recovery factors of radioactive spheres were measured and their comparison with simulated recovery coefficients yielded the tomographic spatial resolution. Following this methodology, resolution was determined in different surrounding media and several conditions for reconstruction, including clinical conditions for brain PET studies. All spatial resolution values were compared with those obtained using classical methods with point and line sources., Results: In each considered condition, spatial resolution of the PET image estimated using the recovery coefficient showed good agreement with classical methods measurements, validating the procedure., Conclusion: Measurement of the recovery coefficient provides an assessment of tomographic spatial resolution, particularly in clinical studies conditions., (2009 Elsevier Ltd. All rights reserved.)
- Published
- 2010
- Full Text
- View/download PDF
39. BAT: a new target for human obesity?
- Author
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Frühbeck G, Becerril S, Sáinz N, Garrastachu P, and García-Velloso MJ
- Subjects
- Adipogenesis physiology, Adipose Tissue, Brown diagnostic imaging, Adipose Tissue, White physiology, Animals, Anti-Obesity Agents pharmacology, Anti-Obesity Agents therapeutic use, Bone Morphogenetic Protein 7 metabolism, Cold Temperature, DNA-Binding Proteins metabolism, Drug Delivery Systems, Humans, Models, Biological, Obesity metabolism, Obesity physiopathology, Positron-Emission Tomography methods, Sympathetic Nervous System physiology, Transcription Factors metabolism, Adipose Tissue, Brown metabolism, Adipose Tissue, Brown physiology, Obesity drug therapy
- Abstract
Two types of adipose tissue can be distinguished histologically and functionally: white (WAT) and brown adipose tissue (BAT). Whereas BAT is specialized in the production of heat, WAT stores excess energy as triacylglycerols. BAT is present throughout life in rodents, whereas in humans it was thought to involute rapidly postnatally, having essentially disappeared within the first years after birth. However, positron emission tomography has provided evidence that adults retain metabolically active BAT depots that can be induced in response to cold and sympathetic nervous system activation. These findings together with the recent identification of specific molecular determinants (PRDM16 and BMP7) activating brown adipogenesis highlights BAT as a potential relevant target for pharmacological and gene expression manipulation to combat human obesity.
- Published
- 2009
- Full Text
- View/download PDF
40. Primary bone lymphoma of the mandible and thyroid incidentaloma identified by FDG PET/CT: a case report.
- Author
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Bosch-Barrera J, Arbea L, García-Velloso MJ, Gil-Bazo I, García-Foncillas J, and Panizo C
- Abstract
The mandible is a rare site for the occurrence of primary bone lymphoma (PBL), a non-Hodgkin lymphoma. We report herein a case of an incidentally diagnosed thyroid incidentaloma by (18)Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in a patient with a previous diagnosis of PBL. Therapeutic options are reviewed and discussed.
- Published
- 2009
- Full Text
- View/download PDF
41. Association between [18F]fluorodeoxyglucose uptake and prognostic parameters in breast cancer.
- Author
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Gil-Rendo A, Martínez-Regueira F, Zornoza G, García-Velloso MJ, Beorlegui C, and Rodriguez-Spiteri N
- Subjects
- Adult, Aged, Aged, 80 and over, Breast Neoplasms pathology, Breast Neoplasms surgery, Carcinoma, Ductal, Breast pathology, Carcinoma, Ductal, Breast surgery, Carcinoma, Intraductal, Noninfiltrating pathology, Carcinoma, Intraductal, Noninfiltrating surgery, Carcinoma, Lobular pathology, Carcinoma, Lobular surgery, Female, Follow-Up Studies, Humans, Middle Aged, Multivariate Analysis, Neoplasm Recurrence, Local etiology, Positron-Emission Tomography, Prognosis, Statistics, Nonparametric, Young Adult, Breast Neoplasms diagnostic imaging, Carcinoma, Ductal, Breast diagnostic imaging, Carcinoma, Intraductal, Noninfiltrating diagnostic imaging, Carcinoma, Lobular diagnostic imaging, Fluorodeoxyglucose F18 pharmacokinetics, Radiopharmaceuticals pharmacokinetics
- Abstract
Background: This study analysed the correlation between [(18)F]fluorodeoxyglucose (FDG) uptake assessed by positron emission tomography (PET) in breast tumours, and histopathological and inmunohistochemical prognostic factors., Methods: FDG-PET was performed before surgery in 275 women with primary breast cancer. The standarized uptake value (SUV) was compared with histopathological findings after surgery., Results: A positive relationship was found between the SUV and tumour size (r = 0.46, P < 0.001), axillary lymph node status (P < 0.001), histological type (P < 0.001), histological grade (P < 0.001), oestrogen receptor status (P < 0.001), p53 (P < 0.001) and Ki-67 (P < 0.001) expression. Multivariable linear regression showed that tumour size, histological grade, Ki-67 expression, oestrogen receptor status and histological type were significantly related to the SUV., Conclusion: The SUV is a preoperative and non-invasive metabolic factor that relates to some prognostic factors in breast cancer.
- Published
- 2009
- Full Text
- View/download PDF
42. [Current state of PET in head and neck tumours: impact on the planning of radiotherapy treatment].
- Author
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Arias de la Vega F, García-Velloso MJ, Asín G, Rico M, Vila MT, and Chicata V
- Subjects
- Head and Neck Neoplasms pathology, Humans, Neoplasm Metastasis, Neoplasm Staging, Head and Neck Neoplasms diagnostic imaging, Head and Neck Neoplasms radiotherapy, Positron-Emission Tomography, Radiotherapy Planning, Computer-Assisted
- Abstract
The use of positron emission tomography (PET) in head and neck tumours is increasingly widespread. To its clinical indications--especially in the staging of patients but also in evaluating response to treatment and in detecting or confirming relapses--is now added its possible therapeutic impact through its contribution to the planning of radiotherapy treatment. The integration of PET images in the radiotherapy process seems promising, although important doubts remain about it, which means that it is still under research. This article reviews the current state of PET in the area of head and neck tumours, as well as its impact on radiotherapy treatment planning.
- Published
- 2009
- Full Text
- View/download PDF
43. [Positron emission tomography in breast cancer].
- Author
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Richter JA, García-Velloso MJ, Domínguez I, Quincoces G, Prieto E, and Rodríguez Fraile M
- Subjects
- Breast Neoplasms pathology, Female, Fluorodeoxyglucose F18, Humans, Neoplasm Staging, Radiopharmaceuticals, Breast Neoplasms diagnostic imaging, Positron-Emission Tomography
- Abstract
PET18FDG is an imaging diagnostic technique that shows changes in glycolitic metabolism that appear at a very early phases in the tumoral process. The main limitation of PET in breast cancer is the detection of small tumor lesions and axillary micrometastases. However it offers important information in the staging of high risk patients, in clinical relapse or in therapeutic evaluation. The new PET-CT devices offer advantages over conventional techniques. It provides a greater precision in the localization of tumoral foci. In spite of current difficulties for clinical applications, fluoro-estradiol (18F-ES) offers the possibilty of studying the presence of estrogenic receptors both in the primary and in the metastases. It may prove to be a useful tool to obtain information about therapeutic management and prognosis of breast cancer.
- Published
- 2008
44. Diagnostic accuracy of FDG PET in the follow-up of platinum-sensitive epithelial ovarian carcinoma.
- Author
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García-Velloso MJ, Jurado M, Ceamanos C, Aramendía JM, Garrastachu MP, López-García G, and Richter JA
- Subjects
- Adult, CA-125 Antigen blood, False Positive Reactions, Female, Humans, Lymphatic Metastasis, Middle Aged, Ovarian Neoplasms pathology, Predictive Value of Tests, Recurrence, Reproducibility of Results, Whole Body Imaging, Antineoplastic Agents pharmacology, Cisplatin pharmacology, Fluorodeoxyglucose F18 pharmacology, Ovarian Neoplasms radiotherapy, Positron-Emission Tomography methods
- Abstract
Purpose: This study was designed to retrospectively evaluate the diagnostic yield of FDG PET for the diagnosis of recurrent ovarian cancer., Methods: Eighty FDG PET scans were performed on 55 patients owing to suspicion of relapse, and 45 FDG PET scans were performed on 31 patients who were clinically disease free. PET results were compared with the results of conventional radiological imaging (CIM) and serum CA 125 levels, and related to pathological findings in 54 cases or clinical follow-up in 71 cases., Results: CIM correctly identified 49 cases with recurrence [sensitivity (SE) 53.3%] ,and there were 27 true negatives [specificity (SP) 81.8%] However, 43 cases were false negative and six were false positive. The positive predictive value (PPV), negative predictive value (NPV) and accuracy (ACC) of CIM were 89%, 38.6% and 60.8%, respectively. FDG PET correctly detected recurrent disease in 80/92 cases (SE 86.9%, p<0.05) and ruled out relapse in 26/33 cases (SP=78.8%). The PPV, NPV and ACC of PET were 91.9%, 68.4% and 84.8%, respectively. Standardised uptake values did not provide additional diagnostic accuracy compared with visual analysis. The CA 125 results showed an SE of 57.6%, an SP of 93.9% and an ACC of 67.2%. In 23 patients with positive serum CA 125 levels, but negative CIM, FDG PET was positive and relapse was confirmed. Furthermore, FDG PET was positive and relapse was confirmed in 11 patients with negative serum CA 125 levels and CIM., Conclusion: FDG PET may detect recurrent ovarian cancer earlier than CIM, with higher sensitivity and even higher diagnostic accuracy.
- Published
- 2007
- Full Text
- View/download PDF
45. 18F-FDG metabolism in a rat model of chronic infarction: a 17-sector semiquantitative analysis.
- Author
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Peñuelas I, Abizanda G, García-Velloso MJ, Gavira JJ, Martí-Climent JM, Ecay M, Collantes M, García de Jalón JA, García-Rodríguez A, Mazo M, Barba J, Richter JA, and Prósper F
- Subjects
- Animals, Disease Models, Animal, Echocardiography, Image Processing, Computer-Assisted, Metabolic Clearance Rate, Radionuclide Imaging, Rats, Rats, Sprague-Dawley, Fluorodeoxyglucose F18 pharmacokinetics, Myocardial Infarction diagnostic imaging, Radiopharmaceuticals pharmacokinetics
- Abstract
Unlabelled: Strategies to establish the functional benefit of cell therapy in cardiac regeneration and the potential mechanism are needed., Aims: Development of a semi-quantitative method for non invasive assessment of cardiac viability and function in a rat model of myocardial infarction (MI) based on the use of microPET., Animals, Methods: Ten rats were subjected to myocardial imaging 2, 7, 14, 30, 60 and 90 days after left coronary artery ligation. Intravenous 18F-fluoro-2-deoxy-2-D-glucose (18F-FDG) was administered and regional 18F activity concentrations per unit area were measured in 17 regions of interest (ROIs) drawn on cardiac polar maps. By comparing the differences in 18F uptake between baseline and each of the follow up time points, parametric polar maps of statistical significance (PPMSS) were calculated. Left ventricular ejection fraction (LVEF) was blindly assessed echocardiographically. All animals were sacrificed for histopathological analysis after 90 days., Results: The diagnostic quality of 18F-FDG microPET images was excellent. PPMSS demonstrated a statistically significant decrease in 18F concentrations as early as 48 hours after MI in 4 of the 17 ROIs (segments 7, 13, 16 and 17; p < 0.05) that persisted throughout the study. Semiquantitative analysis of 18F-FDG uptake correlated with echocardiographic decrease in LVEF (p < 0.001)., Conclusion: The use of PPMSS based on 18F-FDG-microPET provides valuable semi-quantitative information of heart glucose metabolism allowing for non-invasive follow up thus representing a useful strategy for assessment of novel therapies in cardiac regeneration.
- Published
- 2007
46. Simple automated system for simultaneous production of 11C-labeled tracers by solid supported methylation.
- Author
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Quincoces G, Peñuelas I, Valero M, Serra P, Collantes M, Martí-Climent J, Arbizu J, García-Velloso MJ, and Richter JA
- Subjects
- Choline chemical synthesis, Chromatography, High Pressure Liquid, Methionine chemical synthesis, Methylation, Carbon Radioisotopes chemistry, Choline analogs & derivatives, Methionine analogs & derivatives, Radiopharmaceuticals chemical synthesis
- Abstract
We herein describe a simple setup for the automated simultaneous synthesis of L-[methyl-11C]methionine and N-[methyl-11C]choline by solid-supported methylation. The setup is extremely simple and easy to adapt to other automated systems and due to its versatility, the method can be utilized for the production of other radiopharmaceuticals requiring a simple [11C]methylation step. Furthermore, it can be used for multiple simultaneous synthesis.
- Published
- 2006
- Full Text
- View/download PDF
47. Fluorodeoxyglucose positron emission tomography with sentinel lymph node biopsy for evaluation of axillary involvement in breast cancer.
- Author
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Gil-Rendo A, Zornoza G, García-Velloso MJ, Regueira FM, Beorlegui C, and Cervera M
- Subjects
- Adult, Aged, Aged, 80 and over, Axilla diagnostic imaging, Axilla pathology, Breast Neoplasms pathology, False Negative Reactions, Female, Fluorodeoxyglucose F18, Humans, Lymph Nodes pathology, Lymphatic Metastasis diagnostic imaging, Middle Aged, Positron-Emission Tomography methods, Predictive Value of Tests, Prospective Studies, Regression Analysis, Sensitivity and Specificity, Sentinel Lymph Node Biopsy methods, Breast Neoplasms diagnostic imaging, Lymph Node Excision methods, Lymph Nodes diagnostic imaging, Radiopharmaceuticals
- Abstract
Background: This study analysed the value of [(18)F]fluorodeoxyglucose positron emission tomography (FDG-PET) in detecting axillary lymph node involvement in women with breast cancer., Methods: In the first 150 women in this prospective study, axillary lymph node dissection (ALND) was performed regardless of the PET results. In a second group (125 women) FDG-PET was complemented with sentinel lymph node biopsy (SLNB) only in those who did not have pathological axillary uptake., Results: The sensitivity and specificity of FDG-PET in detecting axillary involvement was 84.5 and 98.5 per cent respectively in the whole series of 275 patients, with two false-positive and 22 false-negative results. False-negative results were associated with some intrinsic tumour characteristics. In 21 women, PET revealed pathological uptake, suggesting involvement of the internal mammary lymph node chain. Whole-body PET identified a second synchronous tumour in five asymptomatic patients and haematogenous metastases in two patients., Conclusion: The high positive predictive value of PET (98.4 per cent) suggests that FDG uptake in the axilla could be an indication for full ALND without previous SLNB., (Copyright (c) 2006 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.)
- Published
- 2006
- Full Text
- View/download PDF
48. Myocardial perfusion imaging with adenosine triphosphate predicts the rate of cardiovascular events.
- Author
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Coma-Canella I, Palazuelos J, Bravo N, and García Velloso MJ
- Subjects
- Adenosine metabolism, Adenosine Triphosphate metabolism, Aged, Cardiovascular Diseases pathology, Female, Humans, Male, Middle Aged, Perfusion, Proportional Hazards Models, Time Factors, Adenosine Triphosphate chemistry, Cardiovascular Diseases diagnosis, Myocardium pathology, Tomography, Emission-Computed, Single-Photon methods
- Abstract
Background: Adenosine triphosphate (ATP) has effects similar to adenosine, including a very short half-life, with the advantage of a much lower cost. Our aim was to evaluate whether myocardial single photon emission computed tomography (SPECT) with ATP can predict the rate of hard events., Methods and Results: We studied 299 patients (188 men; mean age, 64 +/- 10 years) with known or suspected coronary disease with thallium 201 SPECT during ATP infusion and at rest. Perfusion defects were divided into the following: absent/mild reversible, moderate/severe reversible, and mixed/fixed. During a maximum follow-up of 87 months (mean, 32.7 +/- 20.3 months), the rate of cardiovascular events was studied. The prognostic value of different variables that can influence survival was calculated with the Cox proportional hazards model. The total number of cardiovascular events was 115 (43 hard events). The annual rate of hard events according to type of perfusion defect was 3.44% (95% confidence interval [CI], 2.12-5.26) for absent/mild reversible, 6.06% (95% CI, 2.23-13.20) for moderate/severe reversible, and 15.12% (95% CI, 8.64-24.55) for mixed/fixed. In the Cox model the variables that significantly predicted hard events were age greater than 55 years (P = .0293), diabetes (P = .0036), and severe perfusion defects (P = .0008)., Conclusion: ATP can be used for pharmacologic stress testing. SPECT with ATP has a stronger correlation with the rate of hard events than clinical variables.
- Published
- 2006
- Full Text
- View/download PDF
49. Positron emission tomography use in the diagnosis and follow up of Takayasu's arteritis.
- Author
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Moreno D, Yuste JR, Rodríguez M, García-Velloso MJ, and Prieto J
- Subjects
- Adult, Disease Progression, Female, Fluorodeoxyglucose F18, Follow-Up Studies, Humans, Immunosuppressive Agents therapeutic use, Radiopharmaceuticals, Takayasu Arteritis drug therapy, Positron-Emission Tomography, Takayasu Arteritis diagnostic imaging
- Published
- 2005
- Full Text
- View/download PDF
50. [Imaging modalities in cardiology: the present answers to permanent questions].
- Author
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Barba J, Bastarrika G, and García Velloso MJ
- Subjects
- Cardiology, Cardiovascular Diseases diagnostic imaging, Clinical Trials as Topic, Echocardiography, Humans, Magnetic Resonance Imaging, Tomography, Emission-Computed, Tomography, X-Ray Computed, Cardiovascular Diseases diagnosis
- Abstract
Tremendous advances have been made in non-invasive cardiology, such as improved visualization of the anatomy and function of the heart and better understanding of heart disease. Echocardiography has improved in both simplicity and complexity, offering a range of modalities from small, hand-held devices that provide basic information simply and inexpensively to complex, dynamic three-dimensional imaging of regional myocardial function. Cardiovascular magnetic resonance imaging is the newest technique for non-invasive cardiology. It assesses cardiac function, mass and volume and can detect myocardial infarction, fibrosis, valvular and congenital heart disease. Computed tomography is used to detect and quantify coronary heart disease and coronary calcium, high scores being related to increased risk, but its use remains controversial. Myocardial perfusion scintigraphy single photon emission computed tomography (SPECT) is cost effective in investigating patients with suspected coronary disease and acute coronary syndrome. Also positron emission tomography (PET) is useful in the study of perfusion, metabolism, patients selection for revascularization, and in translational research in transgenic animal models.
- Published
- 2005
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