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Your search keyword '"García-Carrasco, Alicia"' showing total 12 results
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12 results on '"García-Carrasco, Alicia"'

2. #2925 PI3K/AKT/mTOR pathway regulates renal expression of Klotho

Author

Pérez-Gómez, Aurora, primary, Tocados, Juan Miguel Díaz, additional, Coral, Juan Diego Domínguez, additional, García-Carrasco, Alicia, additional, Caus, Maite, additional, Schanstra, Joost, additional, Del Bello, Arnaud, additional, Klein, Julie, additional, and Valdivielso, José Manuel, additional

Published
2024
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5. Antihypertensive Effects of an Optimized Aged Garlic Extract in Subjects with Grade I Hypertension and Antihypertensive Drug Therapy: A Randomized, Triple-Blind Controlled Trial

Author

Serrano, José C. E., primary, Castro-Boqué, Eva, additional, García-Carrasco, Alicia, additional, Morán-Valero, María Inés, additional, González-Hedström, Daniel, additional, Bermúdez-López, Marcelino, additional, Valdivielso, José Manuel, additional, Espinel, Alberto E., additional, and Portero-Otín, Manuel, additional

Published
2023
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8. MO551: Targeted Ablation of PTEN in Osteocytes Induces Severe Anemia and Increases FGF23 Production in Renal Insufficiency

Author

Miguel Diaz-Tocados, Juan, primary, Pérez-Gomez, Aurora, additional, Diego Dominguez Coral, Juan, additional, Ángel Rodríguez Martín, Miguel, additional, García-Carrasco, Alicia, additional, Martinez Bardaji, Ana, additional, Eritja Sanjuan, Auria, additional, Caus Enriquez, Maite, additional, Bozic, Milica, additional, and M. Valdivielso, Jose, additional

Published
2022
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10. Importancia de las abejas para el planeta, ¿es posible un mundo sin abejas?

Author

García Carrasco, Alicia, Daza Navarro, María Paula, and Universidad de Sevilla. Departamento de Biología Celular

Subjects
Scientific education, Abejas, Polinización, Biodiversity, Pollination, Educación Científica, Biodiversidad
Abstract

La gran labor que hacen las abejas en el proceso de polinización, es un tema desconocido por la gran mayoría de personas. Además, dicho tema no se está trabajando con ímpetu en las aulas de Educación Primaria, y mucho menos en etapas superiores. Con esta investigación, se ha llevado a cabo un estudio tanto en estudiantes de la Facultad de Ciencias de la Educación de la Universidad de Sevilla como en niños de Educación Primaria de un centro escolar público de Sevilla, con el fin de averiguar cuáles son sus conocimientos (previos y finales) sobre las abejas y la polinización. Para ello, se ha desarrollado un cuestionario inicial y final, junto con sesiones formativas que han ayudado al alumnado a conocer y a interesarse por este tema. The great work that bees do in the pollination process is a subject unknown by mostpeople. Additionally, this topic is not being worked on with vigour in Primary Education classrooms, and less in higher stages. In this research, a study has been carried out withstudents of the Faculty of Educationof the University of Seville and withpupils of PrimaryEducationof a school in Sevilla, in order to find out what their knowledges (previous and final) about bees and pollination process is. For this, an initial and final survey has been developed, along with training sessions that have helped students to learn about it and become interested in this topic. Universidad de Sevilla. Grado en Educación Primaria

Published
2022

12. Relationship between immunoglobulin A1 lectin-binding specificities, mesangial C4d deposits and clinical phenotypes in immunoglobulin A nephropathy.

Author

Medrano, Alfons Segarra, Muijsemberg, Andrea, Wimbury, David, Martin, Marisa, Jatem, Elias, González, Jorge, Colás-Campás, Laura, García-Carrasco, Alicia, Martínez, Cristina, and Barratt, Jonathan

Subjects
IGA glomerulonephritis, LECTINS, RECEIVER operating characteristic curves, ENZYME-linked immunosorbent assay, ACUTE kidney failure, PHENOTYPES, NEURAMINIDASE
Abstract

Background The reason why mesangial C4d deposits are detected in only certain biopsies of immunoglobulin A nephropathy (IGAN) remains unclear. We analyse the association between IgA glycosylation patterns, mesangial C4 deposition and clinical phenotypes in IgAN. Methods This cross-sectional study included 145 patients with idiopathic IgAN. We measured the serum levels of three different IgA1 lectin-binding specificities using enzyme-linked immunosorbent assays with and without treatment with neuraminidase and we analysed the relationship between these glycoforms, C4d mesangial deposits and clinical phenotypes. Results C4d-positive versus Cd4-negative patients had higher proteinuria [median 3.1 g/g (0.9–4.2) versus 1.8 (1–2.2); P = 0.000], haematuria [223 cells/µL (32–278) versus 99 (25–186); P = 0.000] and higher levels of IgA binding to neuraminidase untreated Helix aspersa (HA IgA1 neu−; 150.6 ± 52 U versus 96.2 ± 64.1; P = 0.000), neuraminidase untreated Helix pomatia (HPA IgA1 neu−; 0.34 ± 0.15 U versus 0.27 ± 0.13; P = 0.04), Triticum vulgaris (TV IgA1; 85.1 ± 31.7 U versus 42.2 ± 26.9; P = 0.000) and Canavalia ensiformis (ConA IgA1; 32.5 ± 18 U versus 16.7 ± 9.38; P = 0.000). The levels of HA IgA1 neu−, HPA IgA1 neu−, TV IgA1 and ConA IgA1 were all associated with the mesangial deposition of C4d, extracapillary proliferation and acute kidney injury. In receiver operating characteristics curves, HA IgA1 neu−, HPA IgA1 neu−, TV IgA1 and ConA IgA1 significantly discriminated between C4d-positive ad C4d-negative biopsies. In logistics models, TV IgA1 and ConA IgA1 were the only independent predictors of mesangial C4d deposits. Conclusions In IgAN, the severity of the disease is associated with the level of IgA exposing N -acetyl- d -galactosamine, N -acetyl- d -glucosamine or mannose, whereas C4d deposits are only associated with elevated levels of IgA1 glycoforms exhibiting glycan residues with specificity for mannose and N -acetyl- d -glucosamine binding lectins. [ABSTRACT FROM AUTHOR]

Published
2022
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