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4. The Current Role of the Heavy/Light Chain Assay in the Diagnosis, Prognosis and Monitoring of Multiple Myeloma: An Evidence-Based Approach

Author

Ríos-Tamayo, Rafael, Puig, Noemí, Algarín, Macarena, García de Veas Silva, José Luís, Barbosa, Nuno, Encinas, Cristina, Hernández, José Ángel, Alonso, Rafael, Campos, María Luisa, Rodríguez, Teresa, Leivas, Alberto, Olivares, María José, Sánchez, María José, Paiva, Bruno, Lahuerta, Juan José, Martínez-López, Joaquín, [Ríos-Tamayo,R] Hematology Department, Hospital Universitario Virgen de las Nieves, Granada, Spain. [Ríos-Tamayo,R, Sánchez,MJ] Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA), Granada, Spain. [Ríos-Tamayo,R, Sánchez,MJ] Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. [Puig,N] Hematology Department, Hospital Universitario de Salamanca (HUSAL), IBSAL, IBMCC (USAL-CSIC) CIBERONC, Salamanca, Spain. [Algarín,M, Barbosa,N, Campos,ML, Leivas,A] Scientific Department, The Binding Site Iberia, Barcelona, Spain. [García de Veas Silva,JL] Molecular Diagnosis Laboratory Department, Hospital Universitario Virgen del Rocío, Sevilla, Spain. [Encinas,C] Hematology Department, Hospital General Universitario Gregorio Marañón, IiGM, Madrid, Spain. [Hernández,JÁ] Hematology Department, Hospital Universitario Infanta Leonor, Madrid, Spain. [Alonso,R, Martínez-López,J] Hematology Department, Hospital Universitario 12 de Octubre, Madrid, Spain. [Rodríguez,T, Olivares,MJ] Immunology Department, Hospital Universitario Virgen de las Nieves, Granada, Spain. [Sánchez,MJ] Registro de Cáncer de Granada, Escuela Andaluza de Salud Pública (EASP), Granada, Spain. [Sánchez,MJ] Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain. [Paiva,B] Clínica Universidad de Navarra, CIMA, CIBERONC, IDISNA, Pamplona, Spain. [Lahuerta,JJ, and Martínez-López,J] Instituto de Investigación del Hospital Universitario 12 de Octubre, Madrid, Spain.

Subjects
Cadenas ligeras de inmunoglobulina, Monitoring, Hevylite, Diagnóstico, Diseases::Hemic and Lymphatic Diseases::Hematologic Diseases::Blood Protein Disorders::Paraproteinemias [Medical Subject Headings], Mieloma múltiple, Pronóstico, Cadenas pesadas de inmunoglobulina, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Globulins::Serum Globulins::Immunoglobulins::Immunoglobulin Subunits::Immunoglobulin Light Chains [Medical Subject Headings], Prognosis, Heavy/light chain assay, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Procesamiento automatizado de datos, Multiple myeloma, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis [Medical Subject Headings], Diagnosis, Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Plasma Cell [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis [Medical Subject Headings], Inmunoensayo, Monitorización del ambiente, Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Plasma Cell::Multiple Myeloma [Medical Subject Headings]
Abstract

Despite tremendous progress being made in recent years, multiple myeloma (MM) remains a challenging disease. The laboratory plays a critical role in the overall management of patients. The diagnosis, prognosis, clinical monitoring and evaluation of the response are key moments in the clinical care process. Conventional laboratory methods have been and continue to be the basis of laboratory testing in monoclonal gammopathies, along with the serum free light chain test. However, more accurate methods are needed to achieve new and more stringent clinical goals. The heavy/light chain assay is a relatively new test which can overcome some of the limitations of the conventional methods for the evaluation of intact immunoglobulin MM patients. Here, we report an update of the evidence accumulated in recent years on this method regarding its use in MM. Yes

Published
2021

5. The Current Role of the Heavy/Light Chain Assay in the Diagnosis, Prognosis and Monitoring of Multiple Myeloma: An Evidence-Based Approach

Author

Ríos Tamayo, Rafael, Puig, Noemí, Algarín, Macarena, García de Veas Silva, José Luís, Barbosa, Nuno, Encinas, Cristina, Alonso, Rafael, Campos, María Luisa, Hernández Rivas, José Ángel, Rodríguez, Teresa, Leivas, Alberto, Olivares, María José, Sánchez, María José, Paiva, Bruno, Lahuerta, Juan José, Martínez López, Joaquín, Ríos Tamayo, Rafael, Puig, Noemí, Algarín, Macarena, García de Veas Silva, José Luís, Barbosa, Nuno, Encinas, Cristina, Alonso, Rafael, Campos, María Luisa, Hernández Rivas, José Ángel, Rodríguez, Teresa, Leivas, Alberto, Olivares, María José, Sánchez, María José, Paiva, Bruno, Lahuerta, Juan José, and Martínez López, Joaquín

Abstract

Despite tremendous progress being made in recent years, multiple myeloma (MM) remains a challenging disease. The laboratory plays a critical role in the overall management of patients. The diagnosis, prognosis, clinical monitoring and evaluation of the response are key moments in the clinical care process. Conventional laboratory methods have been and continue to be the basis of laboratory testing in monoclonal gammopathies, along with the serum free light chain test. However, more accurate methods are needed to achieve new and more stringent clinical goals. The heavy/light chain assay is a relatively new test which can overcome some of the limitations of the conventional methods for the evaluation of intact immunoglobulin MM patients. Here, we report an update of the evidence accumulated in recent years on this method regarding its use in MM., Depto. de Medicina, Fac. de Medicina, TRUE, pub

Published
2021

6. The current role of the heavy/light chain assay in the diagnosis, prognosis and monitoring of multiple myeloma: An evidence-based approach

Author

Ríos-Tamayo, R., Puig, Noemi, Algarín, Macarena, García de Veas Silva, José Luís, Barbosa, Nuno, Encinas, Cristina, Hernández, José Ángel, Alonso, Rafael, Campos, María Luisa, Rodríguez, Teresa, Leivas, Alberto, Olivares, María José, Sánchez, María José, Paiva, Bruno, Lahuerta, Juan José, Martínez-López, Joaquín, Ríos-Tamayo, R., Puig, Noemi, Algarín, Macarena, García de Veas Silva, José Luís, Barbosa, Nuno, Encinas, Cristina, Hernández, José Ángel, Alonso, Rafael, Campos, María Luisa, Rodríguez, Teresa, Leivas, Alberto, Olivares, María José, Sánchez, María José, Paiva, Bruno, Lahuerta, Juan José, and Martínez-López, Joaquín

Abstract

Despite tremendous progress being made in recent years, multiple myeloma (MM) remains a challenging disease. The laboratory plays a critical role in the overall management of patients. The diagnosis, prognosis, clinical monitoring and evaluation of the response are key moments in the clinical care process. Conventional laboratory methods have been and continue to be the basis of laboratory testing in monoclonal gammopathies, along with the serum free light chain test. However, more accurate methods are needed to achieve new and more stringent clinical goals. The heavy/light chain assay is a relatively new test which can overcome some of the limitations of the conventional methods for the evaluation of intact immunoglobulin MM patients. Here, we report an update of the evidence accumulated in recent years on this method regarding its use in MM.

Published
2021

8. Multiple Myeloma with Prior Precursor Disease Shows Better Outcome

Author

Ríos-Tamayo, Rafael, primary, Sáinz Pérez, Juan, additional, Jurado, Manuel, additional, Puerta Puerta, Jose Manuel, additional, González Sierra, Pedro Antonio, additional, Romero Aguilar, Antonio, additional, Lopez Fernandez, Elisa, additional, Moratalla Lopez, Lucia, additional, García de Veas Silva, José Luís, additional, Rodríguez Ruiz, Teresa, additional, Jiménez Moleón, José Juan, additional, and Sánchez Pérez, María José, additional

Published
2015
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