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11 results on '"Garcia, Daniel Fernandez"'

3. Abstract 587: Genomic copy number profiling of single CTCs reveals clonal evolution in metastatic breast cancer and identifies actionable targets for informing treatment decisions

Author

Garcia, Daniel Fernandez, primary, Nteliopoulos, Georgios, additional, Hastings, Robert, additional, Rushton, Amelia, additional, Page, Karen, additional, Martinson, Luke J., additional, Gray, Molly, additional, Guttery, David S., additional, Ferrarini, Alberto, additional, Manaresi, Nicolò, additional, Coombes, Charles, additional, and Shaw, Jacqui, additional

Published
2021
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4. Circulating cell-free DNA levels are associated with adverse outcomes in heart failure: testing liquid biopsy in heart failure

Author

Salzano, Andrea, primary, Israr, Muhammad Zubair, additional, Garcia, Daniel Fernandez, additional, Middleton, Laura, additional, D’Assante, Roberta, additional, Marra, Alberto M, additional, Arcopinto, Michele, additional, Yazaki, Yoshiyuki, additional, Bernieh, Dennis, additional, Cassambai, Shabana, additional, Page, Karen, additional, Rengo, Giuseppe, additional, Bossone, Eduardo, additional, Cittadini, Antonio, additional, Shaw, Jacqueline A, additional, and Suzuki, Toru, additional

Published
2020
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10. The pioneer factor PBX1 is a novel driver of metastatic progression in ERα-positive breast cancer

Author

Magnani, Luca, Patten, Darren K., Nguyen, Van T. M., Hong, Sung-Pil, Steel, Jennifer H., Patel, Naina, Lombardo, Ylenia, Faronato, Monica, Gomes, Ana R., Woodley, Laura, Page, Karen, Guttery, David, Primrose, Lindsay, Garcia, Daniel Fernandez, Shaw, Jacqui, Viola, Patrizia, Green, Andrew, Nolan, Christopher, Ellis, Ian O., Rakha, Emad A., Shousha, Sami, Lam, Eric W.-F., Lupien, Mathieu, and Coombes, Charles R.

Subjects
Nottingham Breast Cancer Research Centre, hemic and lymphatic diseases, fungi
Abstract

Over 30% of ER? breast cancer patients develop relapses and progress to metastatic disease despite treatment with endocrine therapies. The pioneer factor PBX1 translates epigenetic cues and mediates estrogen induced ER? binding. Here we demonstrate that PBX1 plays a central role in regulating the ER? transcriptional response to epidermal growth factor (EGF) signaling. PBX1 regulates a subset of EGF-ER? genes highly expressed in aggressive breast tumours. Retrospective stratification of luminal patients using PBX1 protein levels in primary cancer further demonstrates that elevated PBX1 protein levels correlate with earlier metastatic progression. In agreement, PBX1 protein levels are significantly upregulated during metastatic progression in ER?-positive breast cancer patients. Finally we reveal that PBX1 upregulation in aggressive tumours is partly mediated by genomic amplification of the PBX1 locus. Correspondingly, ER?-positive breast cancer patients carrying PBX1 amplification are characterized by poor survival. Notably, we demonstrate that PBX1 amplification can be identified in tumor derived-circulating free DNA of ER?-positive metastatic patients. Metastatic patients with PBX1 amplification are also characterized by shorter relapse-free survival. Our data identifies PBX1 amplification as a functional hallmark of aggressive ER?-positive breast cancers. Mechanistically, PBX1 amplification impinges on several critical pathways associated with aggressive ER?-positive breast cancer.

Published
2015

11. The pioneer factor PBX1 is a novel driver of metastatic progression in ERα-positive breast cancer

Author

Magnani, Luca, primary, Patten, Darren K., additional, Nguyen, Van T.M., additional, Hong, Sung-Pil, additional, Steel, Jennifer H., additional, Patel, Naina, additional, Lombardo, Ylenia, additional, Faronato, Monica, additional, Gomes, Ana R., additional, Woodley, Laura, additional, Page, Karen, additional, Guttery, David, additional, Primrose, Lindsay, additional, Garcia, Daniel Fernandez, additional, Shaw, Jacqui, additional, Viola, Patrizia, additional, Green, Andrew, additional, Nolan, Christopher, additional, Ellis, Ian O., additional, Rakha, Emad A., additional, Shousha, Sami, additional, Lam, Eric W.-F., additional, Győrffy, Balázs, additional, Lupien, Mathieu, additional, and Coombes, R. Charles, additional

Published
2015
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