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BACKGROUND: Longitudinal data assessing the impact of Iodine deficiency on mortality are scarce. We aimed to study the association between the state of iodine nutrition and the risk of total and cause-specific mortality in a representative sample of the Spanish adult population.; METHODS: We performed a longitudinal observational study to estimate mortality risk according to urinary iodine (UI) concentrations using a sample of 4370 subjects >18 years representative of the Spanish adult population participating in the nation-wide study Di@bet.es (2008-2010). We used Cox regression to assess the association between UI at the start of the study (

In addition to their antibiotic effect, macrolides appear to modulate the inflammatory response in cystic fibrosis (CF) and could influence oxidative stress. The objective of this study was to assess oxidation biomarkers and levels of inflammation and to determine whether there is an association between these parameters and the intake of macrolides.The subjects included in this cross-sectional study were, on the one hand, clinically stable patients with CF and, on the other, healthy controls. The following serum and plasma inflammatory and oxidative stress biomarkers were measured: interleukin-6 (IL-6), reactive C protein (RCP), tumor necrosis alpha (TNF-α), glutathione peroxidase (GPx), total antioxidant capacity (TAC), catalase (CAT), and superoxide dismutase (SOD), together with markers of lipid peroxidation (8-isoprostanes and thiobarbituric acid reactive substances [TBARS]). Clinical, anthropometric, lung function, radiological, and analytical variables (albumin, prealbumin, vitamins, and zinc) were also recorded.We studied 36 adults with CF and 41 controls. No differences were observed in age, gender, or anthropometric variables. The patients had significantly higher levels of IL-6, TNF-α, RCP, TBARS, and isoprostanes, and lower levels of SOD than the controls. Twenty-three of the patients were treated with azithromycin, and they had more severe clinical and radiological parameters than those who were not but nevertheless presented significantly lower levels of TNF-α. No differences were observed in the markers of oxidation.Inflammation and oxidation biomarkers were increased in patients with CF compared with controls. The use of azithromycin was associated with reduced TNF-α levels and did not influence oxidation parameters.Makrolitlerin, antibiyotik etkilerine ek olarak, kistik fibrolizlerde (KF) enflamatuvar yanıtı değiştirdikleri görülmektedir ve oksidatif stresi etkileyebilirler. Bu çalışmanın amacı enflamasyon düzeylerini ve oksidasyon biyobelirteçlerini değerlendirmek ve bu parametreler ile makrolit alımı arasında bir ilişki olup olmadığını belirlemektir.Bu kesitsel çalışmaya klinik olarak stabil kistik fibrozis (KF) hastaları ve sağlıklı controller dahil edildi. Şu serum ve plazma enflamatuvar ve oksidatif stres biyobelirteçleri ölçüldü: Lipid peroksidasyon belirteçleri (8-isoprostanler ve TBARs) ile birlikte, interlökin-6 (IL6), C-reaktif protein (CRP), tümör nekroz factor alfa (TNF-α), glutatyon peroksidaz (GPx), total antioksidan kapasite (TAC), katalaz (CAT) ve süperoksit dismutaz (SOD). Aynı zamanda klinik, antropometrik, akciğer fonksiyonu, radyolojik ve analitik değişkenler de (albümin, prealbümin, vitaminler ve çinko) kaydedildi.Otuz altı yetişkin KF hastası ve kırk bir kontrol grubu hastası ile çalışma yapıldı. Yaş, cinsiyet ve de antropometrik değişkenler açısından farklılık gözlenmedi. Kontrollerle kıyaslandığında, KF hastalarında IL-6, TNF-α, RCP, TBARS ve izoprostan düzeyleri önemli ölçüde daha yüksekti ve SOD düzeyleri daha düşüktü. Hastaların 23’üne azitromisin tedavisi verildi ve bu tedaviyi almayan hastalara göre daha ağır klinik ve radyolojik parametreler sergilediler, ancak TNF-α düzeyleri anlamlı ölçüde daha düşüktü. Oksidasyon belirteçlerinde farklılık gözlenmedi.Enflamasyon ve oksidasyon biyobelirteçleri KF hastalarında kontrollere göre yüksekti. Azitromisin kullanımı düşük TNF-α düzeyleri ile ilişkili bulundu ve oksidasyon parametrelerini etkilemedi.

Although iodine nutrition in Spain has improved in recent years, the problem is not completely resolved. It is necessary that health institutions establish measures to ensure an adequate iodine nutrition of the population, especially among the highest risk groups (children and adolescents, women of childbearing age, pregnant women and nursing mothers). A low salt intake should be advised, but it should be iodized. It is also imperative that food control agencies establish effective control over adequate iodization of salt. Indicators on iodine nutrition should be included in future health surveys. The EUthyroid study and the Krakow Declaration on iodine nutrition provide an opportunity to set up a pan-European plan for the prevention of iodine deficiency that should be considered and used by health authorities. (C) 2019 SEEN y SED. Published by Elsevier Espana, S.L.U. All rights reserved.

Objective: To analyze the reference range of thyroid-stimulating hormone (TSH) in different BMI categories and its impact on the classification of hypothyroidism. Methods: The study included 3,928 individuals free of thyroid disease (without previous thyroid disease, no interfering medications, TSH < 10 mu UI/mL and thyroid peroxidase antibodies [TPO Abs] < 50 IU/mL) who participated in a national, cross-sectional, population-based study and were representative of the adult population of Spain. Data gathered included clinical and demographic characteristics, physical examination, and blood and urine sampling. TSH, free thyroxine, free triiodothyronine, and TPO Ab were analyzed by electrochemiluminescence (E170, Roche Diagnostics, Basel, Switzerland). Results: The reference range (p2.5-97.5) for TSH was estimated as 0.6 to 4.8 mu UI/mL in the underweight category (BMI= 40). By using the reference criteria for the normal-weight population, the prevalence of high TSH levels increased threefold in the morbid obesity category (P < 0.01). Conclusions: Persons with morbid obesity might be inappropriately classified if the standard ranges of normality of TSH for the normal-weight population are applied to them.

10.1186/1472-6793-12-4 The expansion of adipose tissue is linked to the development of its vasculature, which appears to have the potential to regulate the onset of obesity. However, at present, there are no studies highlighting the relationship between human adipose tissue angiogenesis and obesity-associated insulin resistance (IR).