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2. Correction to: A phase II/III randomized clinical trial of CisPlatin plUs Gemcitabine and Nabpaclitaxel (GAP) as pReoperative chemotherapy versus immediate resection in patIents with resecTable BiliarY tract cancers (BTC) at high risk for recurrence: PURITY study

Author

Niger, Monica, Nichetti, Federico, Fornaro, Lorenzo, Pircher, Chiara, Morano, Federica, Palermo, Federica, Rimassa, Lorenza, Pressiani, Tiziana, Berardi, Rossana, Gardini, Andrea Casadei, Sperti, Elisa, Salvatore, Lisa, Melisi, Davide, Bergamo, Francesca, Siena, Salvatore, Mosconi, Stefania, Longarini, Rafaella, Arcangeli, Giuseppina, Corallo, Salvatore, Delliponti, Laura, Tamberi, Stefano, Fea, Elena, Brandi, Giovanni, Rapposelli, Ilario Giovanni, Salati, Massimiliano, Baili, Paolo, Miceli, Rosalba, Ljevar, Silva, Cavallo, Ilaria, Sottotetti, Elisa, Martinetti, Antonia, Busset, Michele Droz Dit, Sposito, Carlo, Di Bartolomeo, Maria, Pietrantonio, Filippo, de Braud, Filippo, and Mazzaferro, Vincenzo

Published
2024
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3. A phase II/III randomized clinical trial of CisPlatin plUs Gemcitabine and Nabpaclitaxel (GAP) as pReoperative chemotherapy versus immediate resection in patIents with resecTable BiliarY Tract Cancers (BTC) at high risk for recurrence: PURITY study

Author

Niger, Monica, Nichetti, Federico, Fornaro, Lorenzo, Pircher, Chiara, Morano, Federica, Palermo, Federica, Rimassa, Lorenza, Pressiani, Tiziana, Berardi, Rossana, Gardini, Andrea Casadei, Sperti, Elisa, Salvatore, Lisa, Melisi, Davide, Bergamo, Francesca, Siena, Salvatore, Mosconi, Stefania, Longarini, Raffaella, Arcangeli, Giuseppina, Corallo, Salvatore, Delliponti, Laura, Tamberi, Stefano, Fea, Elena, Brandi, Giovanni, Rapposelli, Ilario Giovanni, Salati, Massimiliano, Baili, Paolo, Miceli, Rosalba, Ljevar, Silva, Cavallo, Ilaria, Sottotetti, Elisa, Martinetti, Antonia, Busset, Michele Droz Dit, Sposito, Carlo, Di Bartolomeo, Maria, Pietrantonio, Filippo, de Braud, Filippo, and Mazzaferro, Vincenzo

Published
2024
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5. Potential feasibility of atezolizumab-bevacizumab therapy in patients with hepatocellular carcinoma treated with tyrosine-kinase inhibitors

Author

Biselli, Maurizio, Caraceni, Paolo, Gramenzi, Annagiulia, Tovoli, Francesco, Granito, Alessandro, Muratori, Luca, Benevento, Francesca, Allegrini, Gloria, Cammà, Calogero, Celsa, Ciro, Giuffrida, Paolo, Stornello, Caterina, Grova, Mauro, Giacchetto, Carmelo Marco, Rancatore, Gabriele, Grassini, Maria Vittoria, Adotti, Valentina, Gitto, Stefano, Marra, Fabio, Rosi, Martina, Bevilacqua, Vittoria, Borghi, Alberto, Gardini, Andrea Casadei, Conti, Fabio, Dall'Aglio, Anna Chiara, Ercolani, Giorgio, Mirici, Federica, de Matthaeis, Nicoletta, Ponziani, Francesca Romana, Missale, Gabriele, Olivani, Andrea, Guarino, Maria, Cossiga, Valentina, Capasso, Mario, Cela, Ester Marina, Facciorusso, Antonio, Lauria, Valentina, Ghittoni, Giorgia, Pelecca, Giorgio, Chegai, Fabrizio, Coratella, Fabio, Ortenzi, Mariano, Dell'Isola, Serena, Franzè, Maria Stella, Saitta, Carlo, Sauchella, Assunta, Dajti, Elton, Ravaioli, Federico, Pieri, Giulia, Torres, Maria Corina Plaz, Oliveri, Filippo, Ricco, Gabriele, Romagnoli, Veronica, Inno, Alessandro, Marchetti, Fabiana, Coccoli, Pietro, Malerba, Antonio, Cappelli, Alberta, Golfieri, Rita, Mosconi, Cristina, Matteo Renzulli, Stefanini, Benedetta, Bucci, Laura, Santi, Valentina, Reggidori, Nicola, Rampoldi, Davide, Lani, Lorenzo, Sangiovanni, Angelo, Cabibbo, Giuseppe, Farinati, Fabio, Campani, Claudia, Foschi, Francesco Giuseppe, Svegliati-Baroni, Gianluca, Raimondo, Giovanni, Gasbarrini, Antonio, Mega, Andrea, Biasini, Elisabetta, Sacco, Rodolfo, Morisco, Filomena, Caturelli, Eugenio, Vidili, Gianpaolo, Azzaroli, Francesco, Giannini, Edoardo G., Rapaccini, Gian Ludovico, Brunetto, Maurizia Rossana, Masotto, Alberto, Nardone, Gerardo, Di Marco, Mariella, Magalotti, Donatella, and Trevisani, Franco

Published
2022
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6. Characteristics and survival of patients with primary biliary cholangitis and hepatocellular carcinoma

Author

Biselli, Maurizio, Caraceni, Paolo, Gramenzi, Annagiulia, Benevento, Francesca, Granito, Alessandro, Muratori, Luca, Piscaglia, Fabio, Bertellini, Federica, Farinati, Fabio, Palano, Giorgio, Pelizzaro, Filippo, Penzo, Barbara, Pinto, Elisa, Allegrini, Gloria, Cammà, Calogero, Celsa, Ciro, Giuffrida, Paolo, Stornello, Caterina, Grova, Mauro, Giacchetto, Carmelo Marco, Rancatore, Gabriele, Grassini, Maria Vittoria, Adotti, Valentina, Gitto, Stefano, Marra, Fabio, Rosi, Martina, Bevilacqua, Vittoria, Borghi, Alberto, Gardini, Andrea Casadei, Conti, Fabio, Napoli, Lucia, Domenicali, Marco, Migliano, Maria Teresa, de Matthaeis, Nicoletta, Ponziani, Francesca Romana, Olivani, Andrea, Missale, Gabriele, Cossiga, Valentina, Capasso, Mario, Morisco, Filomena, Cela, Ester Marina, Facciorusso, Antonio, Lauria, Valentina, Ghittoni, Giorgia, Pelecca, Giorgio, Chegai, Fabrizio, Coratella, Fabio, Ortenzi, Mariano, Dell'Isola, Serena, Franzè, Maria Stella, Saitta, Carlo, Sauchella, Assunta, Dajti, Elton, Ravaioli, Federico, Oliveri, Filippo, Ricco, Gabriele, Romagnoli, Veronica, Inno, Alessandro, Marchetti, Fabiana, Coccoli, Pietro, Malerba, Antonio, Cappelli, Alberta, Golfieri, Rita, Mosconi, Cristina, Renzulli, Matteo, Giannini, Edoardo G., Pieri, Giulia, Labanca, Sara, Plaz Torres, Maria Corina, Gasbarrini, Antonio, Biasini, Elisabetta, Campani, Claudia, Cazzagon, Nora, Foschi, Francesco Giuseppe, Mega, Andrea, Masotto, Alberto, Raimondo, Giovanni, Rapaccini, Gian Ludovico, Sacco, Rodolfo, Caturelli, Eugenio, Guarino, Maria, Tovoli, Francesco, Vidili, Gianpaolo, Brunetto, Maurizia Rossana, Nardone, Gerardo, Svegliati-Baroni, Gianluca, Magalotti, Donatella, Azzaroli, Francesco, Cabibbo, Giuseppe, Di Marco, Maria, Sangiovanni, Angelo, and Trevisani, Franco

Published
2022
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7. Identification of PRMT5 as a therapeutic target in cholangiocarcinoma.

Author

Elurbide, Jasmin, Colyn, Leticia, Latasa, Maria U., Uriarte, Iker, Mariani, Stefano, Lopez-Pascual, Amaya, Valbuena, Emiliana, Castello-Uribe, Borja, Arnes-Benito, Robert, Adan-Villaescusa, Elena, Martinez-Perez, Luz A., Azkargorta, Mikel, Elortza, Felix, Hanghang Wu, Krawczyk, Marcin, Schneider, Kai Markus, Sangro, Bruno, Aldrighetti, Luca, Ratti, Francesca, and Gardini, Andrea Casadei

Subjects
MOLECULAR biology, WEIGHT loss, GENE expression, CYTOLOGY, SMALL molecules, AGE factors in cancer, PEER review of students
Published
2025
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8. Hepatocellular Cancer

Author

Memeo, Riccardo, Pessaux, Patrick, Silvestris, Nicola, Brunetti, Oronzo, Solimando, Antonio Giovanni, Gardini, Andrea Casadei, Riva Sanseverino, Eleonora, Editor-in-Chief, Amenta, Carlo, Series Editor, Carapezza, Marco, Series Editor, Chiodi, Marcello, Series Editor, Laghi, Andrea, Series Editor, Maresca, Bruno, Series Editor, Micale, Giorgio Domenico Maria, Series Editor, Mocciaro Li Destri, Arabella, Series Editor, Öchsner, Andreas, Series Editor, Piva, Mariacristina, Series Editor, Russo, Antonio, Series Editor, Seel, Norbert M., Series Editor, Peeters, Marc, editor, Incorvaia, Lorena, editor, and Rolfo, Christian, editor

Published
2021
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9. Material deprivation affects the management and clinical outcome of hepatocellular carcinoma in a high-resource environment

Author

Avanzato, Francesca, Biselli, Maurizio, Caraceni, Paolo, Garuti, Francesca, Gramenzi, Annagiulia, Neri, Andrea, Santi, Valentina, Pellizzaro, Filippo, Imondi, Angela, Sartori, Anna, Penzo, Barbara, Sanmarco, Ambra, Granito, Alessandro, Muratori, Luca, Piscaglia, Fabio, Sansone, Vito, Forgione, Antonella, Dajti, Elton, Marasco, Giovanni, Ravaioli, Federico, Cappelli, Alberta, Golfieri, Rita, Mosconi, Cristina, Renzulli, Matteo, Cela, Ester Marina, Facciorusso, Antonio, Cacciato, Valentina, Casagrande, Edoardo, Moscatelli, Alessandro, Pellegatta, Gaia, de Matthaeis, Nicoletta, Allegrini, Gloria, Lauria, Valentina, Ghittoni, Giorgia, Pelecca, Giorgio, Chegai, Fabrizio, Coratella, Fabio, Ortenzi, Mariano, Missale, Gabriele, Olivani, Andrea, Inno, Alessandro, Marchetti, Fabiana, Busacca, Anita, Cabibbo, Giuseppe, Cammà, Calogero, Di Martino, Vincenzo, Maria Rizzo, Giacomo Emanuele, Franzè, Maria Stella, Saitta, Carlo, Sauchella, Assunta, Berardinelli, Dante, Bevilacqua, Vittoria, Borghi, Alberto, Gardini, Andrea Casadei, Conti, Fabio, Dall'Aglio, Anna Chiara, Ercolani, Giorgio, Adotti, Valentina, Arena, Umberto, Di Bonaventura, Chiara, Campani, Claudia, Dragoni, Gabriele, Gitto, Stefano, Laffi, Giacomo, Coccoli, Pietro, Malerba, Antonio, Guarino, Maria, Capasso, Maria, Oliveri, Filippo, Romagnoli, Veronica, Cucchetti, Alessandro, Johnson, Philip, Giannini, Edoardo G., Tovoli, Francesco, Rapaccini, Gian Ludovico, Marra, Fabio, Caturelli, Eugenio, Gasbarrini, Antonio, Svegliati-Baroni, Gianluca, Sacco, Rodolfo, Zoli, Marco, Morisco, Filomena, Di Marco, Maria, Mega, Andrea, Foschi, Francesco G., Biasini, Elisabetta, Masotto, Alberto, Nardone, Gerardo, Raimondo, Giovanni, Azzaroli, Francesco, Vidili, Gianpaolo, Brunetto, Maurizia R., Farinati, Fabio, and Trevisani, Franco

Published
2021
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10. Is there an association between commonly employed biomarkers of liver fibrosis and liver stiffness in the general population?

Author

Foschi, Francesco Giuseppe, Domenicali, Marco, Giacomoni, Pierluigi, Dall’Aglio, Anna Chiara, Conti, Fabio, Borghi, Alberto, Bevilacqua, Vittoria, Napoli, Lucia, Mirici, Federica, Cucchetti, Alessandro, Ercolani, Giorgio, Gardini, Andrea Casadei, Bellentani, Stefano, Gastaldelli, Amalia, Giuffrè, Mauro, Tiribelli, Claudio, and Bedogni, Giorgio

Published
2020
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12. Circulating microRNAs as biomarkers for stratifying different phases of liver cancer progression and response to therapy.

Author

D'Abundo, Lucilla, Bassi, Cristian, Callegari, Elisa, Moshiri, Farzaneh, Guerriero, Paola, Michilli, Angelo, Mora, Fernanda, Gardini, Andrea Casadei, Sangiovanni, Angelo, Piscaglia, Fabio, Sabbioni, Silvia, Gramantieri, Laura, and Negrini, Massimo

Subjects
NUCLEOTIDE sequencing, LIVER cancer, HEPATOCELLULAR carcinoma, BLOOD serum analysis, LIVER diseases
Abstract

Hepatocellular carcinoma (HCC) is the most common liver cancer and is among the leading causes of cancer-related death worldwide. There is no reliable biomarker for the early diagnosis of HCC. Circulating microRNAs (miRNAs) have attracted attention as potential biomarkers of disease. By small-RNA next-generation sequencing, the analysis of serum miRNAs led to the identification of molecular signatures able to discriminate advanced HCC from early HCC (n = 246); advanced HCC from CIRRHOSIS (n = 299); advanced HCC from HEALTHY (n = 320); HEALTHY from early HCC (n = 343); and HEALTHY from CIRRHOSIS (n = 414). Cirrhotic patients and early HCC patients exhibited similar serum miRNA profiles, yet a small number of miRNAs (n = 57) were able to distinguish these two classes of patients. A second objective of the study was to identify serum miRNAs capable of predicting the response to therapy in patients with advanced HCC. All patients were treated with sorafenib as first-line therapy: 24 were nonresponsive and 24 responsive. Analysis of circulating miRNAs revealed a 54 miRNAs signature able to separate the two subgroups. This study suggested that circulating miRNAs could be useful biomarkers for monitoring patients with liver diseases ranging from cirrhosis to advanced HCC and possibly predicting susceptibility to first-line treatment based on sorafenib. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Hepatocellular Cancer

Author

Memeo, Riccardo, primary, Pessaux, Patrick, additional, Silvestris, Nicola, additional, Brunetti, Oronzo, additional, Solimando, Antonio Giovanni, additional, and Gardini, Andrea Casadei, additional

Published
2021
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14. 93P The survival impact of the addition of durvalumab to cisplatin/gemcitabine in advanced biliary tract cancer: A real-world, retrospective, multicentric study

Author

Rimini, M., primary, Persano, M., additional, Fornaro, L., additional, Antonuzzo, L., additional, Lonardi, S., additional, Rimassa, L., additional, Niger, M., additional, Silletta, M., additional, Tamburini, E., additional, Giordano, G., additional, Scartozzi, M., additional, Pastorino, A., additional, Martinelli, E., additional, Rizzato, M.D., additional, and Gardini, A. Casadei, additional

Published
2023
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15. 88P Adverse events (AEs) as potential predictive factors of activity in patients with advanced hepatocellular carcinoma (HCC) treated with atezolizumab plus bevacizumab (AB)

Author

Persano, M., primary, Rimini, M., additional, Tada, T., additional, Suda, G., additional, Shimose, S., additional, Kudo, M., additional, Yoo, C., additional, Cheon, J., additional, Finkelmeier, F., additional, Lim, H.Y., additional, Presa, J., additional, Masi, G., additional, Bergamo, F., additional, Iavarone, M.A., additional, Cabibbo, G., additional, Foschi, F.G., additional, Piscaglia, F., additional, Cascinu, S., additional, Scartozzi, M., additional, and Gardini, A. Casadei, additional

Published
2023
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16. Correction to: Angiogenesis Genotyping and Clinical Outcomes in Patients with Advanced Hepatocellular Carcinoma Receiving Sorafenib: The ALICE‑2 Study

Author

Faloppi, Luca, Puzzoni, Marco, Gardini, Andrea Casadei, Silvestris, Nicola, Masi, Gianluca, Marisi, Giorgia, Vivaldi, Caterina, Gadaleta, Cosmo Damiano, Ziranu, Pina, Bianconi, Maristella, Loretelli, Cristian, Demurtas, Laura, Lai, Eleonora, Giampieri, Riccardo, Galizia, Eva, Ulivi, Paola, Battelli, Nicola, Falcone, Alfredo, Cascinu, Stefano, and Scartozzi, Mario

Published
2020
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18. Defining and predicting textbook outcomes for perihilar cholangiocarcinoma: analysis of factors improving achievement of desired postoperative outcomes.

Author

Clocchiatti, Lucrezia, Marino, Rebecca, Ratti, Francesca, Pedica, Federica, Gardini, Andrea Casadei, Lorenzin, Dario, and Aldrighetti, Luca

Abstract

Background: Definition of textbook outcome (TO), defined as a single indicator combining the most advantageous short-term outcomes, is still lacking for perihilar cholangiocarcinoma (PHC). The primary endpoint of the present study is to analyze the rate of achievement of a disease-specific TO for PHC within a high volume tertiary referral centre. Secondary endpoints are to identify predictive factors of TO-achievement and to analyze the impact of achieving TO on long-term results. Methods: Between 2010 and 2022, a total of 237 patients undergoing combined liver and biliary resection for PHC at tertiary referral centre were included. Disease-specific TO were defined as: no 90-day mortality, no postoperative complications, no readmission, no intraoperative transfusions and resection margins. A logistic regression model was developed to identify predictors associated with TO-achievement. Kaplan-Meier curves were designed to determine TO's impact on survival. Results: TO was achieved in 60 (25.3%) patients. At multivariate logistic regression, preoperative biliary drainage [odds ratio (OR) 2.90 (1.13-3.40), P= 0.026], high prognostic nutritional index [OR 7.11 (6.71-9.43), P=0.007[ and minimally invasive approach [OR 3.57 (2.31-3.62), P=0.013] were identified as independent predictors of TO. High ASA score [OR 0.38 (0.17-0.82), P= 0.013] decreased the odds of TO. A significant improvement in both overall survival and disease-free survival was associated to TO fulfilment. Conclusion: Since the achievement of TO correlates with better disease-free and overall survival, every effort should be made to ameliorate modifiable aspects prior to surery: management within referral centres with dedicated experience in biliary tract cancer and preoperative optimization protocol may positively contribute to improve postoperative outcomes, increasing the chance to obtain TO. Moreover, the implementation of advanced minimally invasive programs plays as well. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Sequential therapies after atezolizumab plus bevacizumab or lenvatinib first-line treatments

Author

Persano, Mara, primary, Rimini, Margherita, additional, Tada, Toshifumi, additional, Suda, Goki, additional, Shigeo, Shimose, additional, Kudo, Masatoshi, additional, Cheon, Jaekyung, additional, Finkelmeier, Fabian, additional, Presa, José, additional, Masi, Gianluca, additional, Yoo, Changhoon, additional, Lonardi, Sara, additional, Piscaglia, Fabio, additional, Iavarone, Massimo, additional, Di Costanzo, Giuseppe, additional, Marra, Fabio, additional, Cabibbo, Giuseppe, additional, Foschi, Francesco, additional, Siletta, Marianna, additional, Cascinu, Stefano, additional, Scartozzi, Mario, additional, and Gardini, Andrea Casadei, additional

Published
2023
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20. Deep learning predicts sensitivity to atezolizumab-bevacizumab from digital slides of hepatocellular carcinoma

Author

Zeng, Qinghe, primary, Klein, Christophe, additional, Caruso, Stefano, additional, Maille, Pascale, additional, Allende, Daniela, additional, Minguez, Beatriz, additional, Iavarone, Massimo, additional, Ningarhari, Massih, additional, Gardini, Andrea Casadei, additional, Pedica, Federica, additional, Rimini, Margherita, additional, perbellini, Riccardo, additional, Boulagnon-Rombi, Camille, additional, Heurgue-berlot, Alexandra, additional, Maggioni, Marco, additional, Rela, Mohd., additional, Vij, Mukul, additional, Baulande, Sylvain, additional, Legoix, Patricia, additional, Lameiras, Sonia, additional, Labgaa, Ismail, additional, Sempoux, Christine, additional, Digkilia, Antonia, additional, Ghaffari-Laleh, Narmin, additional, Kather, Jakob Nikolas, additional, El Nahhas, Omar, additional, Navale, Pooja, additional, Torres, Callie, additional, Su, Tung-Hung, additional, Graham, Rondell, additional, Salcedo, María, additional, Bermúdez, María, additional, Tran, Nguyen H., additional, Pawlotsky, Jean-Michel, additional, Verset, Gontran, additional, Trépo, Eric, additional, Varela, Maria, additional, Castano-Garcia, Andrés, additional, Wendum, Dominique, additional, Amaddeo, Giuliana, additional, Regnault, Helene, additional, Lequoy, Marie, additional, Díaz, Alba, additional, Reig, María, additional, Radu, Pompilia, additional, Dufour, Jean-François, additional, Chan, Stephen, additional, Gopal, Purva, additional, Bruges, Léa, additional, Gnemmi, Viviane, additional, Nault, Jean Charles, additional, Rhee, Hyungjin, additional, Park, Young Nyun, additional, Iñarrairaegui, Mercedes, additional, Argemi, Josep Maria, additional, Sangro, Bruno, additional, D’Alessio, Antonio, additional, Scheiner, Bernhard, additional, Pinato, David J., additional, Pinter, Matthias, additional, Paradis, Valérie, additional, Beaufrère, Aurélie, additional, Peter, Simon, additional, Rimassa, Lorenza, additional, Di Tommaso, Luca, additional, Vogel, Arndt, additional, Michalak, Sophie, additional, Boursier, Jerome, additional, Loménie, Nicolas, additional, Ziol, Marianne, additional, and Calderaro, Julien, additional

Published
2023
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21. Incidence and risk factors of esophagogastric varices bleeding in patients with advanced hepatocellular carcinoma treated with lenvatinib

Author

Iavarone, Massimo, primary, Alimenti, Eleonora, additional, Tada, Toshifumi, additional, Shigeo, Shimose, additional, Suda, Goki, additional, Yoo, Changhoon, additional, Soldà, Caterina, additional, Piscaglia, Fabio, additional, Gardini, Andrea Casadei, additional, Marra, Fabio, additional, Vivaldi, Caterina, additional, Conti, Fabio, additional, Schirripa, Marta, additional, Iwamoto, Hideki, additional, Sho, Takuya, additional, Leo, So Heun, additional, Rizzato, Mario Domenico, additional, Tonnini, Matteo, additional, Rimini, Margherita, additional, Campani, Claudia, additional, Masi, Gianluca, additional, Foschi, Francesco, additional, Bruccoleri, Mariangela, additional, Kawaguchi, Takumi, additional, Kumada, Takashi, additional, Hiraoka, Atsushi, additional, Atsukawa, Masanori, additional, Fukunishi, Shinya, additional, Ishikawa, Toru, additional, Tajiri, Kazuto, additional, Ochi, Hironori, additional, Yasuda, Satoshi, additional, Toyoda, Hidenori, additional, Hatanaka, Takeshi, additional, Kakizaki, Satoru, additional, Kawata, Kazuhito, additional, Tada, Faujimasa, additional, Ohama, Hideko, additional, Itokawa, Norio, additional, Okubo, Tomomi, additional, Arai, Taeang, additional, Imai, Michitaka, additional, Naganuma, Atsushi, additional, Tosetti, Giulia, additional, and Lampertico, Pietro, additional

Published
2023
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23. Recalibrating survival prediction among patients receiving trans‐arterial chemoembolization for hepatocellular carcinoma

Author

Cucchetti, Alessandro, Giannini, Edoardo G., Mosconi, Cristina, Plaz Torres, Maria Corina, Pieri, Giulia, Farinati, Fabio, Rapaccini, Gian Ludovico, Di Marco, Maria, Caturelli, Eugenio, Sacco, Rodolfo, Cabibbo, Giuseppe, Campani, Claudia, Mega, Andrea, Guarino, Maria, Gasbarrini, Antonio, Svegliati‐Baroni, Gianluca, Foschi, Francesco Giuseppe, Missale, Gabriele, Masotto, Alberto, Nardone, Gerardo, Raimondo, Giovanni, Vidili, Gianpaolo, Brunetto, Maurizia Rossana, Sansone, Vito, Zoli, Marco, Azzaroli, Francesco, Trevisani, Franco, Biselli, Maurizio, Caraceni, Paolo, Gramenzi, Annagiulia, Rampoldi, Davide, Reggidori, Nicola, Santi, Valentina, Stefanini, Benedetta, Granito, Alessandro, Muratori, Luca, Piscaglia, Fabio, Tovoli, Francesco, Magalotti, Donatella, Dajti, Elton, Marasco, Giovanni, Ravaioli, Federico, Cappelli, Alberta, Golfieri, Rita, Renzulli, Matteo, Pelizzaro, Filippo, Penzo, Barbara, Marina Cela, Ester, Facciorusso, Antonio, Cacciato, Valentina, Casagrande, Edoardo, de Matthaeis, Nicoletta, Allegrini, Gloria, Lauria, Valentina, Ghittoni, Giorgia, Pelecca, Giorgio, Chegai, Fabrizio, Coratella, Fabio, Ortenzi, Mariano, Dell'Isola, Serena, Biasini, Elisabetta, Olivani, Andrea, Inno, Alessandro, Marchetti, Fabiana, Celsa, Ciro, Grova, Mauro, Stornello, Caterina, Busacca, Anita, Cammà, Calogero, Maria Rizzo, Giacomo Emanuele, Franzè, Maria Stella, Saitta, Carlo, Sauchella, Assunta, Napoli, Lucia, Bevilacqua, Vittoria, Berardinelli, Dante, Borghi, Alberto, Gardini, Andrea Casadei, Conti, Fabio, Dall'Aglio, Anna Chiara, Ercolani, Giorgio, Marra, Fabio, Di Bonaventura, Chiara, Gitto, Stefano, Adotti, Valentina, Coccoli, Pietro, Malerba, Antonio, Capasso, Mario, Morisco, Filomena, Oliveri, Filippo, Romagnoli, Veronica, Cucchetti, Alessandro, Giannini, Edoardo G., Mosconi, Cristina, Plaz Torres, Maria Corina, Pieri, Giulia, Farinati, Fabio, Rapaccini, Gian Ludovico, Di Marco, Maria, Caturelli, Eugenio, Sacco, Rodolfo, Cabibbo, Giuseppe, Campani, Claudia, Mega, Andrea, Guarino, Maria, Gasbarrini, Antonio, Svegliati‐Baroni, Gianluca, Foschi, Francesco Giuseppe, Missale, Gabriele, Masotto, Alberto, Nardone, Gerardo, Raimondo, Giovanni, Vidili, Gianpaolo, Brunetto, Maurizia Rossana, Sansone, Vito, Zoli, Marco, Azzaroli, Francesco, Trevisani, Franco, Biselli, Maurizio, Caraceni, Paolo, Gramenzi, Annagiulia, Rampoldi, Davide, Reggidori, Nicola, Santi, Valentina, Stefanini, Benedetta, Granito, Alessandro, Muratori, Luca, Piscaglia, Fabio, Tovoli, Francesco, Magalotti, Donatella, Dajti, Elton, Marasco, Giovanni, Ravaioli, Federico, Cappelli, Alberta, Golfieri, Rita, Renzulli, Matteo, Pelizzaro, Filippo, Penzo, Barbara, Marina Cela, Ester, Facciorusso, Antonio, Cacciato, Valentina, Casagrande, Edoardo, de Matthaeis, Nicoletta, Allegrini, Gloria, Lauria, Valentina, Ghittoni, Giorgia, Pelecca, Giorgio, Chegai, Fabrizio, Coratella, Fabio, Ortenzi, Mariano, Dell'Isola, Serena, Biasini, Elisabetta, Olivani, Andrea, Inno, Alessandro, Marchetti, Fabiana, Celsa, Ciro, Grova, Mauro, Stornello, Caterina, Busacca, Anita, Cammà, Calogero, Maria Rizzo, Giacomo Emanuele, Franzè, Maria Stella, Saitta, Carlo, Sauchella, Assunta, Napoli, Lucia, Bevilacqua, Vittoria, Berardinelli, Dante, Borghi, Alberto, Gardini, Andrea Casadei, Conti, Fabio, Dall'Aglio, Anna Chiara, Ercolani, Giorgio, Marra, Fabio, Di Bonaventura, Chiara, Gitto, Stefano, Adotti, Valentina, Coccoli, Pietro, Malerba, Antonio, Capasso, Mario, Morisco, Filomena, Oliveri, Filippo, and Romagnoli, Veronica

Subjects
Liver Cancer, Pre-TACE-Predict model, medicine.medical_specialty, business.industry, Trans-arterial chemoembolization, Pharmaceutical Science, hepatocellular carcinoma, medicine.disease, Gastroenterology, Complementary and alternative medicine, Internal medicine, Hepatocellular carcinoma, medicine, Pharmacology (medical), Trans arterial chemoembolization, business
Abstract

Background & Aims The Pre-TACE-Predict model was devised to assess prognosis of patients treated with trans-arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC). However, before entering clinical practice, a model should demonstrate that it performs a useful role. Methods We performed an independent external validation of the Pre-TACE model in a cohort that differs in setting and time period from the one that generated the original model. Data from 826 patients treated with TACE for naïve HCC (2008-2018) were used to assess calibration and discrimination of the Pre-TACE-Predict model. Results The four risk-categories identified by the Pre-TACE-Predict model had gradient monotonicity, with median survivals of 52.0, 36.2, 29.9, and 14.1 months respectively. However, predicted survivals systematically underestimated observed survivals (R2: 0.667). A recalibration was adopted maintaining fixed the prognostic index and modifying the baseline survival function. This resulted in an almost perfect calibration (R2: 0.995) in all the four risk categories. Cox regressions showed that aetiology and macrovascular invasion, included in the Pre-TACE-Predict model, had no prognostic impact in the present study population, and that coefficients for tumour size and multiplicity were overestimated. The c-index was similar to that of the m-HAP-III, but higher than those of HAP, m-HAP-II and the six-and-twelve models. Conclusions The recalibration of Pre-TACE-Predict model improved the estimation of survival probabilities of HCC patients treated with TACE. The highest discriminatory ability of the Pre-TACE-model in comparison to other available models, together with risk stratification and recalibration, makes it the best prognostic tool currently available for these patients.

Published
2021
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25. Characteristics and survival of patients with primary biliary cholangitis and hepatocellular carcinoma

Author

Giannini, Edoardo G., primary, Pieri, Giulia, additional, Labanca, Sara, additional, Plaz Torres, Maria Corina, additional, Gasbarrini, Antonio, additional, Biasini, Elisabetta, additional, Campani, Claudia, additional, Cazzagon, Nora, additional, Foschi, Francesco Giuseppe, additional, Mega, Andrea, additional, Masotto, Alberto, additional, Raimondo, Giovanni, additional, Rapaccini, Gian Ludovico, additional, Sacco, Rodolfo, additional, Caturelli, Eugenio, additional, Guarino, Maria, additional, Tovoli, Francesco, additional, Vidili, Gianpaolo, additional, Brunetto, Maurizia Rossana, additional, Nardone, Gerardo, additional, Svegliati-Baroni, Gianluca, additional, Magalotti, Donatella, additional, Azzaroli, Francesco, additional, Cabibbo, Giuseppe, additional, Di Marco, Maria, additional, Sangiovanni, Angelo, additional, Trevisani, Franco, additional, Biselli, Maurizio, additional, Caraceni, Paolo, additional, Gramenzi, Annagiulia, additional, Benevento, Francesca, additional, Granito, Alessandro, additional, Muratori, Luca, additional, Piscaglia, Fabio, additional, Bertellini, Federica, additional, Farinati, Fabio, additional, Palano, Giorgio, additional, Pelizzaro, Filippo, additional, Penzo, Barbara, additional, Pinto, Elisa, additional, Allegrini, Gloria, additional, Cammà, Calogero, additional, Celsa, Ciro, additional, Giuffrida, Paolo, additional, Stornello, Caterina, additional, Grova, Mauro, additional, Giacchetto, Carmelo Marco, additional, Rancatore, Gabriele, additional, Grassini, Maria Vittoria, additional, Adotti, Valentina, additional, Gitto, Stefano, additional, Marra, Fabio, additional, Rosi, Martina, additional, Bevilacqua, Vittoria, additional, Borghi, Alberto, additional, Gardini, Andrea Casadei, additional, Conti, Fabio, additional, Napoli, Lucia, additional, Domenicali, Marco, additional, Migliano, Maria Teresa, additional, de Matthaeis, Nicoletta, additional, Ponziani, Francesca Romana, additional, Olivani, Andrea, additional, Missale, Gabriele, additional, Cossiga, Valentina, additional, Capasso, Mario, additional, Morisco, Filomena, additional, Cela, Ester Marina, additional, Facciorusso, Antonio, additional, Lauria, Valentina, additional, Ghittoni, Giorgia, additional, Pelecca, Giorgio, additional, Chegai, Fabrizio, additional, Coratella, Fabio, additional, Ortenzi, Mariano, additional, Dell'Isola, Serena, additional, Franzè, Maria Stella, additional, Saitta, Carlo, additional, Sauchella, Assunta, additional, Dajti, Elton, additional, Ravaioli, Federico, additional, Oliveri, Filippo, additional, Ricco, Gabriele, additional, Romagnoli, Veronica, additional, Inno, Alessandro, additional, Marchetti, Fabiana, additional, Coccoli, Pietro, additional, Malerba, Antonio, additional, Cappelli, Alberta, additional, Golfieri, Rita, additional, Mosconi, Cristina, additional, and Renzulli, Matteo, additional

Published
2022
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26. The genomic landscape of IDH1 mutant intrahepatic cholangiocarcinoma: a multicentre comprehensive analysis

Author

Rimini, Margherita, primary, Macarulla, Teresa Mercade, additional, Burgio, Valentina, additional, Lonardi, Sara, additional, Niger, Monica, additional, Scartozzi, Mario, additional, Raposelli, Ilario, additional, Aprile, Giuseppe, additional, Ratti, Francesca, additional, Pedica, Federica, additional, Verdaguer, Helena, additional, Nappo, Floriana, additional, Nichetti, Federico, additional, Lai, Eleonora, additional, Valgiusti, Martina, additional, Cappetta, Alessandro, additional, Fabregat, Carles, additional, Fassan, Matteo, additional, De Braud, Filippo, additional, Puzzoni, Marco, additional, Frassineti, Giovanni Luca, additional, Simionato, Francesca, additional, De Cobelli, Francesco, additional, Aldrighetti, Luca, additional, Fornaro, Lorenzo, additional, Cascinu, Stefano, additional, and Gardini, Andrea Casadei, additional

Published
2022
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27. Proteomic analysis of bile in the rat thioacetamide model reveals new mechanisms in human cholangiocarcinogenesis

Author

Colyn, Leticia, primary, Álvarez-Sola, Gloria, additional, Latasa, Maria U, additional, Uriarte, Iker, additional, Herranz, Jose Maria, additional, Arechederra, Maria, additional, Falcon-Perez, Juan, additional, Pineda, Antonio A, additional, Gardini, Andrea Casadei, additional, Barbas, Coral, additional, Urman, Jesus M, additional, Sangro, Bruno, additional, Banales, Jesus Maria, additional, Martínez-Chantar, María Luz, additional, Marin, Jose, additional, Corrales, Fernando, additional, Elizalde, Maria Iraburu, additional, Cubero, Francisco Javier, additional, Berasain, Carmen, additional, Fernandez-Barrena, Maite G, additional, and Avila, Matías A, additional

Published
2022
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28. Plasma cell-free DNA methylation as biomarker for hepatocellular carcinoma

Author

Gárate-Rascón, María, primary, Recalde, Miriam, additional, Bilbao, Idoia, additional, Daian, Fabrice, additional, Elizalde, María, additional, Azkona, María, additional, Herranz, José María, additional, Rojo, Carla, additional, Iñarrairaegui, Mercedes, additional, Abete, Itziar, additional, Zulet, María A., additional, Sangro, Bruno, additional, Fernandez-Barrena, Maite G., additional, Boix, Loreto, additional, Reig, María, additional, Gardini, Andrea Casadei, additional, Avila, Matías A., additional, Landecho, Manuel F., additional, Berasain, Carmen, additional, and Arechederra, Maria, additional

Published
2022
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30. MiR-22-3p targets the G2/M checkpoint inhibitor Wee1 and represents a possible biomarker of TACE response in hepatocellular carcinoma.

Author

Galvani, G., Vianello, C., Leoni, I., Monti, E., Marisi, G., Gardini, A. Casadei, Foschi, G.F., Lazzari, M.L., Giovannini, C., Ravegnini, G., Salamon, I., Ferracin, M., Piscaglia, F., Negrini, M., Stefanelli, C., Trerè, D., Gramantieri, L., and Fornari, F.

Abstract

Hepatocellular carcinoma (HCC) is a hypervascular tumor and derive most of its blood supply from the hepatic artery. The locoregional treatment transarterial chemoembolization (TACE) represents the gold standard for HCC patients at intermediated stage, with survival rates ranging from 20 to 36 months. Despite the proven effectiveness of TACE, the identification of biomarkers predictive of response to the first or subsequent TACE cycle remains an unmet clinical need. MicroRNAs are pivotal players in drug resistance in HCC and show ideal characteristics as circulating biomarkers. MiR-22-3p is a tumor suppressor gene in several cancers, including HCC. Here, we aimed at identifying novel miR-22-3p targets involved in TACE resistance and at exploring circulating miR-22 as a candidate of TACE response. Serum and tissue miR-22-3p and WEE1 levels were quantified by qPCR and digital droplets PCR in HCC patients at early and intermediate stages, as well as in HCC cell lines. Functional analysis and luciferase reporter assay assessed WEE1 targeting by miR-22-3p in HCC cell lines and xenograft mice. Flow cytometric analysis evaluated cell cycle modulation after miR-22 overexpression or silencing in HCC cells. Live imaging and WB analyses evaluated cell growth and apoptotic cell death in miR-22 modulated HCC cells subjected to hypoxia and doxorubicin treatment. Statistical analysis was performed to investigate clinicopathological associations in TACE-treated patients. An inverse correlation between serum and tissue miR-22 levels was detected in surgically resected HCC patients. Functional analysis and luciferase reporter assay demonstrated WEE1 targeting by miR-22-3p in HCC cell lines and xenograft mice. Cell cycle and BrdU analyses showed a downregulation of G2/M in miR-22-overexpressing cells, and an upregulation in miR-22 stably silenced cells. An increase of cell growth and an inhibition of apoptotic markers was shown in miR-22 silenced cells undergoing hypoxia and doxorubicin treatment. Increased miR-22 serum levels were observed after each TACE cycle with respect to pre-treatment levels. Higher miR-22 levels associated with TACE resistance at 3 and 6 months of follow-up when assessed two days after treatment. Post-treatment miR-22 levels associated with alfa-fetoprotein and tumor size in TACE-treated patients. The cell cycle checkpoint inhibitor WEE1 is a novel miR-22-3p target in HCC and contributes to TACE resistance in low miR-22-expressing HCC cells. If validated in larger cohorts, miR-22-3p represents a promising circulating biomarker of TACE response when analyzed few days after treatment. [ABSTRACT FROM AUTHOR]

Published
2025
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33. Material deprivation affects the management and clinical outcome of hepatocellular carcinoma in a high-resource environment

Author

Cucchetti, Alessandro, primary, Gramenzi, Annagiulia, additional, Johnson, Philip, additional, Giannini, Edoardo G., additional, Tovoli, Francesco, additional, Rapaccini, Gian Ludovico, additional, Marra, Fabio, additional, Cabibbo, Giuseppe, additional, Caturelli, Eugenio, additional, Gasbarrini, Antonio, additional, Svegliati-Baroni, Gianluca, additional, Sacco, Rodolfo, additional, Zoli, Marco, additional, Morisco, Filomena, additional, Di Marco, Maria, additional, Mega, Andrea, additional, Foschi, Francesco G., additional, Biasini, Elisabetta, additional, Masotto, Alberto, additional, Nardone, Gerardo, additional, Raimondo, Giovanni, additional, Azzaroli, Francesco, additional, Vidili, Gianpaolo, additional, Brunetto, Maurizia R., additional, Farinati, Fabio, additional, Trevisani, Franco, additional, Avanzato, Francesca, additional, Biselli, Maurizio, additional, Caraceni, Paolo, additional, Garuti, Francesca, additional, Neri, Andrea, additional, Santi, Valentina, additional, Pellizzaro, Filippo, additional, Imondi, Angela, additional, Sartori, Anna, additional, Penzo, Barbara, additional, Sanmarco, Ambra, additional, Granito, Alessandro, additional, Muratori, Luca, additional, Piscaglia, Fabio, additional, Sansone, Vito, additional, Forgione, Antonella, additional, Dajti, Elton, additional, Marasco, Giovanni, additional, Ravaioli, Federico, additional, Cappelli, Alberta, additional, Golfieri, Rita, additional, Mosconi, Cristina, additional, Renzulli, Matteo, additional, Cela, Ester Marina, additional, Facciorusso, Antonio, additional, Cacciato, Valentina, additional, Casagrande, Edoardo, additional, Moscatelli, Alessandro, additional, Pellegatta, Gaia, additional, de Matthaeis, Nicoletta, additional, Allegrini, Gloria, additional, Lauria, Valentina, additional, Ghittoni, Giorgia, additional, Pelecca, Giorgio, additional, Chegai, Fabrizio, additional, Coratella, Fabio, additional, Ortenzi, Mariano, additional, Missale, Gabriele, additional, Olivani, Andrea, additional, Inno, Alessandro, additional, Marchetti, Fabiana, additional, Busacca, Anita, additional, Cammà, Calogero, additional, Di Martino, Vincenzo, additional, Maria Rizzo, Giacomo Emanuele, additional, Franzè, Maria Stella, additional, Saitta, Carlo, additional, Sauchella, Assunta, additional, Berardinelli, Dante, additional, Bevilacqua, Vittoria, additional, Borghi, Alberto, additional, Gardini, Andrea Casadei, additional, Conti, Fabio, additional, Dall'Aglio, Anna Chiara, additional, Ercolani, Giorgio, additional, Adotti, Valentina, additional, Arena, Umberto, additional, Di Bonaventura, Chiara, additional, Campani, Claudia, additional, Dragoni, Gabriele, additional, Gitto, Stefano, additional, Laffi, Giacomo, additional, Coccoli, Pietro, additional, Malerba, Antonio, additional, Guarino, Maria, additional, Capasso, Maria, additional, Oliveri, Filippo, additional, and Romagnoli, Veronica, additional

Published
2021
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34. Effect of direct-acting antivirals on future occurrence of hepatocellular carcinoma in compensated cirrhotic patients

Author

Cucchetti, Alessandro, D’Amico, Gennaro, Trevisani, Franco, Morelli, Maria Cristina, Vitale, Alessandro, Pinna, Antonio Daniele, Cescon, Matteo, Cillo, Umberto, Burra, Patrizia, Russo, Francesco P., Mescoli, Claudia, Rendina, Maria, Lupo, Luigi G., Losito, Francesco, Fucilli, Fabio, Brancaccio, Giusep-Pina, Persico, Marcello, Viganò, Luca, Iavarone, Massimo, D’Ambrosio, Roberta, Sangiovanni, Angelo, Renzulli, Matteo, Galati, Giovanni, Ponziani, Francesca Romana, Pompili, Maurizio, Miele, Luca, Grieco, Antonio, Rapaccini, Gianlodovico, Gasbarrini, Antonio, Sandri, Giovanni Battisa Levi, Lai, Quirino, Melandro, Fabio, Rossi, Massimo, Lenci, Ilaria, Manzia, Tommaso Maria, Tortora, Raffaella, Di Costanzo, Giovan Giuseppe, Sacco, Rodolfo, Simonetti, Natalia, Morisco, Filomena, Guarino, Maria, Cabibbo, Giuseppe, Bhoori, Carlo Sposito Sherrie, Di Sandro, Stefano, Foschi, Francesco Giuseppe, Gardini, Andrea Casadei, Nicolini, Daniele, Mazzocato, Susanna, Alba, Kostandini, Violi, Paola, Baccarani, Umberto, Pravisani, Riccardo, A. Cucchetti, G. D'Amico, F. Trevisani, M.C. Morelli, A. Vitale, A.D.Pinna, M. Cescon, Cucchetti, Alessandro, D’Amico, Gennaro, Trevisani, Franco, Morelli, Maria Cristina, Vitale, Alessandro, Pinna, Antonio Daniele, Cescon, Matteo, Cillo, Umberto, Burra, Patrizia, Russo, Francesco P., Mescoli, Claudia, Rendina, Maria, Lupo, Luigi G., Losito, Francesco, Fucilli, Fabio, Brancaccio, Giusep-Pina, Persico, Marcello, Viganò, Luca, Iavarone, Massimo, D’Ambrosio, Roberta, Sangiovanni, Angelo, Renzulli, Matteo, Galati, Giovanni, Ponziani, Francesca Romana, Pompili, Maurizio, Miele, Luca, Grieco, Antonio, Rapaccini, Gianlodovico, Gasbarrini, Antonio, Sandri, Giovanni Battisa Levi, Lai, Quirino, Melandro, Fabio, Rossi, Massimo, Lenci, Ilaria, Manzia, Tommaso Maria, Tortora, Raffaella, Di Costanzo, Giovan Giuseppe, Sacco, Rodolfo, Simonetti, Natalia, Morisco, Filomena, Guarino, Maria, Cabibbo, Giuseppe, Bhoori, Carlo Sposito Sherrie, Di Sandro, Stefano, Foschi, Francesco Giuseppe, Gardini, Andrea Casadei, Nicolini, Daniele, Mazzocato, Susanna, Alba, Kostandini, Violi, Paola, Baccarani, Umberto, and Pravisani, Riccardo

Subjects
Male, Time Factors, Sustained Virologic Response, Hepatocellular carcinoma, Hepacivirus, Direct-acting antiviral, Direct-acting antivirals, medicine.disease_cause, Gastroenterology, Competing risk, Hepatitis C, Markov model, Survival benefit, Sustained virological response, Hepatology, 0302 clinical medicine, Risk Factors, 030212 general & internal medicine, biology, Incidence, Incidence (epidemiology), Liver Neoplasms, Middle Aged, Markov Chains, Competing risk Direct-acting antivirals Hepatitis C Hepatocellular carcinoma Markov model Survival benefit Sustained virological response, Italy, Liver Neoplasm, Female, 030211 gastroenterology & hepatology, Human, Adult, medicine.medical_specialty, Carcinoma, Hepatocellular, Time Factor, Hepatitis C virus, Antiviral Agents, 03 medical and health sciences, Internal medicine, medicine, Humans, Antiviral Agent, Hepaciviru, business.industry, Risk Factor, Carcinoma, Hepatocellular, Markov Chain, medicine.disease, biology.organism_classification, digestive system diseases, Settore MED/18 - Chirurgia Generale, Liver function, Varices, business
Abstract

Background: The achievement of high rates of sustained virological response (SVR) with direct-acting antivirals (DAAs) in hepatitis C virus (HCV) infected patients will reduce decompensating terminal events. Aims: To investigate whether hepatocellular carcinoma (HCC) occurrence could change due to the DAA-induced increase in life-expectancy. Methods: A Markov model was built on clinical data of 494 cirrhotic patients and available literature to estimate probabilities of “death before HCC” and of “HCC occurrence” without and with DAA. Results: In comparison to untreated patients, DAA therapy reduced the 20-year mortality before HCC by 21.9% in patients without varices and by 21.5% in those with varices, considering an SVR of 95% and no direct effect on hepatocarcinogenesis. Tumour occurrence increased by 5%–8.2% and the proportion of HCCs diagnosed in compensated stages increased to >98%. If we consider DAA as having “anti-tumoral” effects, the benefit becomes greater, achieving a 20-year survival of 81.5% in patients without varices, and 52.2% in patients with varices. Instead, if we consider DAA as having a “pro-tumoral” effect, then, the increased incidence of HCC nullifies the survival benefits. Conclusion: DAAs drastically reduce the mortality caused by the liver function worsening, increasing the proportion of HCCs diagnosed in compensated stages. Knowledge of the DAA effect on hepatocarcinogenesis remains pivotal. © 2017 Editrice Gastroenterologica Italiana S.r.l.

Published
2018
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36. Hemangioblastoma of the Gastrointestinal Tract: A First Case

Author

Gardini, Andrea Casadei, Pieri, Federica, Fusaroli, Pietro, Oboldi, Devil, Passardi, Alessandro, Monti, Manlio, Rosetti, Paola, Calpona, Sebastiano, Valgiusti, Martina, Ragazzini, Angela, Amadori, Dino, and Frassineti, Giovanni Luca

Published
2013

40. THU-145 - Sequential therapies after atezolizumab plus bevacizumab or lenvatinib first-line treatments

Author

Persano, Mara, Rimini, Margherita, Tada, Toshifumi, Suda, Goki, Shigeo, Shimose, Kudo, Masatoshi, Cheon, Jaekyung, Finkelmeier, Fabian, Presa, José, Masi, Gianluca, Yoo, Changhoon, Lonardi, Sara, Piscaglia, Fabio, Iavarone, Massimo, Di Costanzo, Giuseppe, Marra, Fabio, Cabibbo, Giuseppe, Foschi, Francesco, Siletta, Marianna, Cascinu, Stefano, Scartozzi, Mario, and Gardini, Andrea Casadei

Published
2023
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41. THU-131 - Incidence and risk factors of esophagogastric varices bleeding in patients with advanced hepatocellular carcinoma treated with lenvatinib

Author

Iavarone, Massimo, Alimenti, Eleonora, Tada, Toshifumi, Shigeo, Shimose, Suda, Goki, Yoo, Changhoon, Soldà, Caterina, Piscaglia, Fabio, Gardini, Andrea Casadei, Marra, Fabio, Vivaldi, Caterina, Conti, Fabio, Schirripa, Marta, Iwamoto, Hideki, Sho, Takuya, Leo, So Heun, Rizzato, Mario Domenico, Tonnini, Matteo, Rimini, Margherita, Campani, Claudia, Masi, Gianluca, Foschi, Francesco, Bruccoleri, Mariangela, Kawaguchi, Takumi, Kumada, Takashi, Hiraoka, Atsushi, Atsukawa, Masanori, Fukunishi, Shinya, Ishikawa, Toru, Tajiri, Kazuto, Ochi, Hironori, Yasuda, Satoshi, Toyoda, Hidenori, Hatanaka, Takeshi, Kakizaki, Satoru, Kawata, Kazuhito, Tada, Faujimasa, Ohama, Hideko, Itokawa, Norio, Okubo, Tomomi, Arai, Taeang, Imai, Michitaka, Naganuma, Atsushi, Tosetti, Giulia, and Lampertico, Pietro

Published
2023
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43. LBO-04 - Deep learning predicts sensitivity to atezolizumab-bevacizumab from digital slides of hepatocellular carcinoma

Author

Zeng, Qinghe, Klein, Christophe, Caruso, Stefano, Maille, Pascale, Allende, Daniela, Minguez, Beatriz, Iavarone, Massimo, Ningarhari, Massih, Gardini, Andrea Casadei, Pedica, Federica, Rimini, Margherita, perbellini, Riccardo, Boulagnon-Rombi, Camille, Heurgue-berlot, Alexandra, Maggioni, Marco, Rela, Mohd., Vij, Mukul, Baulande, Sylvain, Legoix, Patricia, Lameiras, Sonia, Labgaa, Ismail, Sempoux, Christine, Digkilia, Antonia, Ghaffari-Laleh, Narmin, Kather, Jakob Nikolas, El Nahhas, Omar, Navale, Pooja, Torres, Callie, Su, Tung-Hung, Graham, Rondell, Salcedo, María, Bermúdez, María, Tran, Nguyen H., Pawlotsky, Jean-Michel, Verset, Gontran, Trépo, Eric, Varela, Maria, Castano-Garcia, Andrés, Wendum, Dominique, Amaddeo, Giuliana, Regnault, Helene, Lequoy, Marie, Díaz, Alba, Reig, María, Radu, Pompilia, Dufour, Jean-François, Chan, Stephen, Gopal, Purva, Bruges, Léa, Gnemmi, Viviane, Nault, Jean Charles, Rhee, Hyungjin, Park, Young Nyun, Iñarrairaegui, Mercedes, Argemi, Josep Maria, Sangro, Bruno, D’Alessio, Antonio, Scheiner, Bernhard, Pinato, David J., Pinter, Matthias, Paradis, Valérie, Beaufrère, Aurélie, Peter, Simon, Rimassa, Lorenza, Di Tommaso, Luca, Vogel, Arndt, Michalak, Sophie, Boursier, Jerome, Loménie, Nicolas, Ziol, Marianne, and Calderaro, Julien

Published
2023
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45. 425P Statins increase pathological response in locally advanced rectal cancer (LARC) treated with chemo-radiation (CRT): A multicentric experience

Author

Santini, C., primary, Caputo, F., additional, Gardini, A. Casadei, additional, Cerma, K., additional, Bardasi, C., additional, Passardi, A., additional, Garajovà, I., additional, Rapposelli, I.G., additional, Lattanzi, E., additional, Spallanzani, A., additional, Bonetti, L. Reggiani, additional, Piccoli, M., additional, Meduri, B., additional, Gelmini, R., additional, Pecchi, A., additional, Benatti, S., additional, Dominici, M., additional, Luppi, G., additional, and Gelsomino, F., additional

Published
2020
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46. P-188 Safety and efficacy of first-line gemcitabine plus nab-paclitaxel for elderly metastatic pancreatic cancer patients

Author

Pecora, I., primary, Vivaldi, C., additional, Rovesti, G., additional, Catanese, S., additional, Salani, F., additional, Gardini, A. Casadei, additional, Massa, V., additional, Bernardini, L., additional, Riggi, M., additional, Andrikou, K., additional, Rapposelli, I., additional, Formica, V., additional, Cesario, S., additional, Caccese, M., additional, Lencioni, M., additional, Vasile, E., additional, Falcone, A., additional, and Fornaro, L., additional

Published
2020
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47. Direct-acting antivirals and hepatocellular carcinoma in chronic hepatitis C: A few lights and many shadows

Author

Guarino, Maria, Sessa, Anna, Cossiga, Valentina, Morando, Federica, Caporaso, Nicola, Morisco, Filomena, Luca, Viganó, Romana, Ponziani Francesca, Maurizio, Pompili, Cillo, Umberto, Burra, Patrizia, Mescoli, Claudia, Gambato, Martina, Russo, FRANCESCO PAOLO, Vitale, Alessandro, Giuseppe, Cabibbo, Mauro, Vigano', Giovanni, Galati, Erica, Villa, Lupo, Luigi G., Maria, Rendina, Losito, Francesco, Fucilli, Fabio, Persico, Marcello, D'Ambrosio, Roberta, Sangiovanni, Angelo, Massimo, Iavarone, Brancaccio, Giuseppina, Cucchetti, Alessandro, Renzulli, Matteo, Franco, Trevisani, Miele, Luca, Grieco, Antonio, Rapaccini, Gianlodovico, Gasbarrini, Antonio, Sandri, Giovanni Battisa Levi, Melandro, Fabio, Rossi, Massimo, Quirino, Lai, Lenci, Ilaria, Manzia, Tommaso Maria, Tortora, Raffaella, Di Costanzo, Giovan Giuseppe, Ghinolfi, Davide, Rreka, Erion, Carrai, Paola, Simonetti, Natalia, Rodolfo, Sacco, Sposito, Carlo, Bhoori, Sherrie, Di Sandro, Stefano, Foschi, Francesco Giuseppe, Gardini, Andrea Casadei, Nicolini, Daniele, Mazzocato, Susanna, Alba, Kostandini, Violi, Paola, Baccarani, Umberto, Pravisani, Riccardo, Vincenzi, Valter, Maria, Guarino, Anna, Sessa, Valentina, Cossiga, Federica, Morando, Nicola, Caporaso, Filomena, Morisco, Viganó, Luca, Ponziani Francesca, Romana, Pompili, Maurizio, Umberto, Cillo, Patrizia, Burra, Claudia, Mescoli, Martina, Gambato, Russo Francesco, Paolo, Vitale, Alessandro, Cabibbo, Giuseppe, Vigano', Mauro, Galati, Giovanni, Villa, Erica, Luigi G., Lupo, Rendina, Maria, Francesco, Losito, Fabio, Fucilli, Marcello, Persico, Roberta, D'Ambrosio, Angelo, Sangiovanni, Iavarone, Massimo, Brancaccio, Giuseppina, Alessandro, Cucchetti, Matteo, Renzulli, Trevisani, Franco, Luca, Miele, Antonio, Grieco, Gianlodovico, Rapaccini, Antonio, Gasbarrini, Giovanni Battisa Levi, Sandri, Fabio, Melandro, Massimo, Rossi, Lai, Quirino, Ilaria, Lenci, Tommaso Maria, Manzia, Raffaella, Tortora, Giovan Giuseppe, Di Costanzo, Davide, Ghinolfi, Erion, Rreka, Paola, Carrai, Natalia, Simonetti, Sacco, Rodolfo, Carlo, Sposito, Sherrie, Bhoori, Stefano, Di Sandro, Francesco Giuseppe, Foschi, Andrea Casadei, Gardini, Daniele, Nicolini, Susanna, Mazzocato, Kostandini, Alba, Paola, Violi, Umberto, Baccarani, Riccardo, Pravisani, Valter, Vincenzi, Guarino, Maria, Sessa, Anna, Cossiga, Valentina, Morando, Federica, Caporaso, Nicola, Morisco, Filomena, Luca, Viganó, Romana, Ponziani Francesca, Maurizio, Pompili, Cillo, Umberto, Burra, Patrizia, Mescoli, Claudia, Gambato, Martina, Paolo, Russo Francesco, Alessandro, Vitale, Giuseppe, Cabibbo, Mauro, Vigano', Giovanni, Galati, Erica, Villa, Lupo, Luigi G., Maria, Rendina, Losito, Francesco, Fucilli, Fabio, Persico, Marcello, D'Ambrosio, Roberta, Sangiovanni, Angelo, Massimo, Iavarone, Giuseppina, Brancaccio, Cucchetti, Alessandro, Renzulli, Matteo, Franco, Trevisani, Miele, Luca, Grieco, Antonio, Rapaccini, Gianlodovico, Gasbarrini, Antonio, Sandri, Giovanni Battisa Levi, Melandro, Fabio, Rossi, Massimo, Quirino, Lai, Lenci, Ilaria, Manzia, Tommaso Maria, Tortora, Raffaella, Di Costanzo, Giovan Giuseppe, Ghinolfi, Davide, Rreka, Erion, Carrai, Paola, Simonetti, Natalia, Rodolfo, Sacco, Sposito, Carlo, Bhoori, Sherrie, Di Sandro, Stefano, Foschi, Francesco Giuseppe, Gardini, Andrea Casadei, Nicolini, Daniele, Mazzocato, Susanna, Alba, Kostandini, Violi, Paola, Baccarani, Umberto, Pravisani, Riccardo, and Vincenzi, Valter

Subjects
Oncology, Cirrhosis, Direct-acting antiviral agent, Sustained Virologic Response, Direct-acting antiviral agents, Hepatitis C virus, Hepatocellular carcinoma, Occurrence, Recurrence, Antiviral Agents, Carcinoma, Hepatocellular, Disease Progression, Hepacivirus, Hepatitis C, Chronic, Humans, Incidence, Liver, Liver Neoplasms, Neoplasm Recurrence, Local, Risk Factors, Treatment Outcome, Gastroenterology, medicine.disease_cause, DIRECT ACTING ANTIVIRALS, 0302 clinical medicine, Chronic, biology, Incidence (epidemiology), Minireviews, General Medicine, Hepatitis C, Local, Liver Neoplasm, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Human, medicine.medical_specialty, Interferon therapy, 03 medical and health sciences, Chronic hepatitis, Internal medicine, medicine, Antiviral Agent, Hepaciviru, business.industry, Risk Factor, Carcinoma, Hepatocellular, medicine.disease, biology.organism_classification, digestive system diseases, Settore MED/18 - Chirurgia Generale, Neoplasm Recurrence, business, Hepatitis C viru
Abstract

With the introduction of direct-acting antiviral agents (DAA), the rate of sustained virological response (SVR) in the treatment of hepatitis C virus (HCV) has radically improved to over 95%. Robust scientific evidence supports a beneficial role of SVR after interferon therapy in the progression of cirrhosis, resulting in a decreased incidence of hepatocellular carcinoma (HCC). However, a debate on the impact of DAAs on the development of HCC is ongoing. This review aimed to analyse the scientific literature regarding the risk of HCC in terms of its recurrence and occurrence after the use of DAAs to eradicate HCV infection. Among 11 studies examining HCC occurrence, the de novo incidence rate ranged from 0 to 7.4% (maximum follow-up: 18 mo). Among 18 studies regarding HCC recurrence, the rate ranged from 0 to 54.4% (maximum "not well-defined" followup: 32 mo). This review highlights the major difficulties in interpreting data and reconciling the results of the included studies. These difficulties include heterogeneous cohorts, potential misclassifications of HCC prior to DAA therapy, the absence of an adequate control group, short follow-up times and different kinds of follow-up. Moreover, no clinical feature-based scoring system accounts for the molecular characteristics and pathobiology of the tumours. Nonetheless, this review does not suggest that there is a higher rate of de novo HCC occurrence or recurrence after DAA therapy in patients with previous HCV infection. © 2018 The Author(s). Published by Baishideng Publishing Group Inc. All rights reserved.

Published
2018

48. SAT180 - The genomic landscape of IDH1 mutant intrahepatic cholangiocarcinoma: a multicentre comprehensive analysis

Author

Rimini, Margherita, Macarulla, Teresa Mercade, Burgio, Valentina, Lonardi, Sara, Niger, Monica, Scartozzi, Mario, Raposelli, Ilario, Aprile, Giuseppe, Ratti, Francesca, Pedica, Federica, Verdaguer, Helena, Nappo, Floriana, Nichetti, Federico, Lai, Eleonora, Valgiusti, Martina, Cappetta, Alessandro, Fabregat, Carles, Fassan, Matteo, De Braud, Filippo, Puzzoni, Marco, Frassineti, Giovanni Luca, Simionato, Francesca, De Cobelli, Francesco, Aldrighetti, Luca, Fornaro, Lorenzo, Cascinu, Stefano, and Gardini, Andrea Casadei

Published
2022
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49. FRI554 - Proteomic analysis of bile in the rat thioacetamide model reveals new mechanisms in human cholangiocarcinogenesis

Author

Colyn, Leticia, Álvarez-Sola, Gloria, Latasa, Maria U, Uriarte, Iker, Herranz, Jose Maria, Arechederra, Maria, Falcon-Perez, Juan, Pineda, Antonio A, Gardini, Andrea Casadei, Barbas, Coral, Urman, Jesus M, Sangro, Bruno, Banales, Jesus Maria, Martínez-Chantar, María Luz, Marin, Jose, Corrales, Fernando, Elizalde, Maria Iraburu, Cubero, Francisco Javier, Berasain, Carmen, Fernandez-Barrena, Maite G, and Avila, Matías A

Published
2022
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50. FRI222 - Plasma cell-free DNA methylation as biomarker for hepatocellular carcinoma

Author

Gárate-Rascón, María, Recalde, Miriam, Bilbao, Idoia, Daian, Fabrice, Elizalde, María, Azkona, María, Herranz, José María, Rojo, Carla, Iñarrairaegui, Mercedes, Abete, Itziar, Zulet, María A., Sangro, Bruno, Fernandez-Barrena, Maite G., Boix, Loreto, Reig, María, Gardini, Andrea Casadei, Avila, Matías A., Landecho, Manuel F., Berasain, Carmen, and Arechederra, Maria

Published
2022
Full Text
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