1,364 results on '"Gardner, Michael J"'
Search Results
2. Incisional negative pressure wound therapy may not protect against post-operative surgical site complications in bicondylar tibial plateau fractures
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Johnson, Taylor R., Oquendo, Yousi A., Seltzer, Ryan, Van Rysselberghe, Noelle L., Bishop, Julius A., and Gardner, Michael J.
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- 2024
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3. Interaction of preoperative chemoprophylaxis and tranexamic acid use does not affect transfusion in acetabular fracture surgery
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Wadhwa, Harsh, Rohde, Matthew, Oquendo, Yousi, Chen, Michael J., Tigchelaar, Seth S., Bellino, Michael, Bishop, Julius, and Gardner, Michael J.
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- 2024
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4. Limb position affects intraoperative assessment of condylar width
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Tucker, Douglass W., Chen, Michael J., Reddy, Akhil, Carney, John J., Gardner, Michael J., and Marecek, Geoffrey S.
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- 2024
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5. Outcomes of isolated medial tibial plateau fractures by fracture morphology
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Cruz, Jacquelyn P, Michaud, Jack B., Van Rysselberghe, Noelle L., Walsh, Daniel, Svetgoff, Reese, Bailey, Ryan, Pirkle, Sarah Bhattacharjee, Megerian, Mark F., Harbison, Gregory J., Becerra, Jacob A., Sakka, Brandan, Vega, Andrew, Bohlen, Hunter L., Holloway, Aeryus, Finlay, Andrea, Scolaro, John A., Patterson, Joseph T., Campbell, Sean T., Hebert-Davies, Jonah, Warner, Stephen J., Goodnough, L.Henry, Bishop, Julius A., and Gardner, Michael J.
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- 2024
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6. The Bioburden Associated with Severe Open Tibial Fracture Wounds at the Time of Definitive Closure or Coverage: The BIOBURDEN Study
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Bosse, Michael J., Joshi, Manjari, Carlini, Anthony R., Firoozabadi, Reza, Murray, Clinton K., Manson, Theodore, Yun, Heather C., Gary, Joshua L., Wenke, Joseph C., Castillo, Renan C., Carroll, Eben A., Goodman, James Brett, Holden, Martha B., Miller, Anna N., Spraggs-Hughes, Amanda, Tornetta, Paul, III, Osborn, Patrick M., DeLeon, Stephanie, Hsu, Joseph R., Karunakar, Madhav A., Seymour, Rachel B., Sims, Stephen H., Churchill, Christine, Fraychineaud, Hannah Gissel, Trujillo, Corey Henderson, Zura, Robert D., Howes, Cameron, Mir, Hassan, Taylor, Benjamin C., Schmidt, Andrew H., Yoon, Patrick, McKinley, Todd O., Sorkin, Anthony, Virkus, Walter W., Krause, Peter C., Lee, Olivia C., Achor, Timothy S., Brinker, Mark R., Choo, Andrew, Munz, John W., Galpin, Matthew C., Frisch, H. Michael, Kaufman, Adam M., Large, Thomas M., LeCroy, C. Michael, Smith, Christopher S., Crickard, Colin V., Langford, Joshua, Reid, J. Spence, Horne, Andrea, O’Toole, Robert V., Eglseder, W. Andrew, Pensy, Raymond A., Crisco, M.J., Zych, Gregory A., Cannada, FAOA; Lisa K., Gardner, Michael J., Rehman, Saqib, Jones, Clifford B., Sietsema, Debra L., Ly, Thuan V., Miclau, Theodore, Morshed, Saam, Kwong, Jonny, Rothberg, David L., Bergin, Patrick F., Bhanat, Eldrin, Graves, Matt L., Spitler, Clay A., Teague, David, Ertl, William, Gorczyca, John T., Lester-Ballard, Veronica, McVey, Eric D., Agel, Julie, Obremskey, William, Burgos, Eduardo J., Gajari, Vamshi, Jahangir, A. Alex, Rodriguez-Buitrago, Andres, Trochez, Karen M., D’Alleyrand, Jean-Claude G., Gordon, Wade T., Ceniceros, Xochitl, Waggoner, Sandra L., and Collins, Susan C.
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- 2024
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7. Do Transtibial Amputations Outperform Amputations of the Hind- and Midfoot Following Severe Limb Trauma?: A Secondary Analysis of the OUTLET Study
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Fram, Brianna R., Bosse, Michael J., Odum, Susan M., Reider, Lisa, Gary, Joshua L., Gordon, Wade T., Teague, David, Alkhoury, Dana, MacKenzie, Ellen J., Seymour, Rachel B., Karunakar, Madhav A., Fox, W. Everett, Hsu, Joseph R., Kempton, Laurence, Robinson, Katherine Sample, Sims, Stephen H., Churchill, Christine, Teasdall, Robert D., Carroll, Eben A., Scott, Aaron T., Halvorson, Jason J., Pilson, Holly, Goodman, James Brett, Holden, Martha B., McAndrew, Christopher M., Gardner, Michael J., Miller, Anna N., Hughes, Amanda Spraggs, Stinner, Daniel J., Rivera, Jessica C., Osborn, Patrick M., Nadeau, Jason T., Howes, Cameron, Schenker, Mara L., Mir, Hassan, Taylor, Benjamin C., Schmidt, Andrew H., Mullis, Brian H., Shively, Karl D., Sorkin, Anthony T., Virkus, Walter, Konda, Sanjit R., Choo, Andrew, Munz, John W., Boutte, Sterling, Breslin, Mary A., Toledano, James E., Langford, Joshua Robert, Horne, Andrea, O’Toole, Robert V., Boulton, Christina, Manson, Theodore, Nascone, Jason, Pollak, Andrew N., Sciadini, Marcus F., Degani, Yasmin, Howe, Andrea L., Zych, Gregory A., Cannada, Lisa K., Dawson, Sarah A., Jones, Clifford B., Sietsema, Debra L., Miclau, Theodore, Morshed, Saam, Wilken, Jason M., Bergin, Patrick F., Graves, Matt L., Spitler, Clay A., Jones, LaRita C., Ertl, William, Moloney, Gele B., Evans, Andrew R., Weiss, David B., Yarboro, Seth R., Lester-Ballard, Veronica, McVey, Eric D., Firoozabadi, Reza, Agel, Julie, Obremskey, William, Archer, Kristin R., Burgos, Eduardo J., Gajari, Vamshi, Rodriguez-Buitrago, Andres, Tummuru, Rajesh R., Trochez, Karen M., D’Alleyrand, Jean-Claude G., Castillo, Renan C., Allen, Lauren E., and Carlini, Anthony R.
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- 2024
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8. Biomechanics of sacroiliac joint fixation using lag screws: a cadaveric study
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Chatain, Grégoire P., Oldham, Alton, Uribe, Juan, Duhon, Bradley, Gardner, Michael J., Witt, Jens-Peter, Yerby, Scott, and Kelly, Brian P.
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- 2023
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9. Range of motion measurements do not correlate with patient reported outcome measures in the early post-operative period following ankle fracture
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Calderon, Christian, Oquendo, Yousi A., Van Rysselberghe, Noelle, Finlay, Andrea K., Hunt, Anastasia A., San Agustin, Micah J., and Gardner, Michael J.
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- 2024
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10. Using machine-learning to decode postoperative hip mortality Trends: Actionable insights from an extensive clinical dataset
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Lin, Christopher Q., Jin, Christopher A., Ivanov, David, Gonzalez, Christian A., and Gardner, Michael J.
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- 2024
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11. Cross-species comparisons reveal resistance of human skeletal stem cells to inhibition by non-steroidal anti-inflammatory drugs
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Goodnough, L Henry, Ambrosi, Thomas H, Steininger, Holly M, Butler, M Gohazrua K, Hoover, Malachia Y, Choo, HyeRan, Van Rysselberghe, Noelle L, Bellino, Michael J, Bishop, Julius A, Gardner, Michael J, and Chan, Charles KF
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Pharmacology and Pharmaceutical Sciences ,Biomedical and Clinical Sciences ,Stem Cell Research ,Transplantation ,Regenerative Medicine ,Musculoskeletal ,Animals ,Anti-Inflammatory Agents ,Non-Steroidal ,Cyclooxygenase 2 ,Cyclooxygenase 2 Inhibitors ,Fractures ,Bone ,Humans ,Mice ,Osteogenesis ,Stem Cells ,skeletal stem cells ,non-steroid antiinflamatory drugs ,species specificity ,bone regeneration ,inflammation ,fracture healing ,Clinical Sciences ,Nutrition and Dietetics ,Clinical sciences - Abstract
Fracture healing is highly dependent on an early inflammatory response in which prostaglandin production by cyclo-oxygenases (COX) plays a crucial role. Current patient analgesia regimens favor opioids over Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) since the latter have been implicated in delayed fracture healing. While animal studies broadly support a deleterious role of NSAID treatment to bone-regenerative processes, data for human fracture healing remains contradictory. In this study, we prospectively isolated mouse and human skeletal stem cells (SSCs) from fractures and compared the effect of various NSAIDs on their function. We found that osteochondrogenic differentiation of COX2-expressing mouse SSCs was impaired by NSAID treatment. In contrast, human SSCs (hSSC) downregulated COX2 expression during differentiation and showed impaired osteogenic capacity if COX2 was lentivirally overexpressed. Accordingly, short- and long-term treatment of hSSCs with non-selective and selective COX2 inhibitors did not affect colony forming ability, chondrogenic, and osteogenic differentiation potential in vitro. When hSSCs were transplanted ectopically into NSG mice treated with Indomethacin, graft mineralization was unaltered compared to vehicle injected mice. Thus, our results might contribute to understanding species-specific differences in NSAID sensitivity during fracture healing and support emerging clinical data which conflicts with other earlier observations that NSAID administration for post-operative analgesia for treatment of bone fractures are unsafe for patients.
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- 2022
12. Deep Surgical Site Infection after Fracture Has a Profound Effect on Functional Outcomes
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Gitajn, Ida Leah, Werth, Paul M., Carlini, Anthony R., Bosse, Michael J., Gary, Joshua L., Firoozabadi, Reza, Obremskey, William, McKinley, Todd O., Castillo, Renan C., O’Toole, Robert V., Westrick, Edward R., Carroll, Eben A., Goodman, James Brett, Holden, Martha B., Miller, Anna N., Spraggs-Hughes, Amanda, Brennan, Michael L., Tornetta, Paul, III, Weaver, Michael J., Heng, Marilyn, Osborn, Patrick M., Rivera, Jessica C., Murray, Clinton K., Kimmel, Joseph E., Moon, Charles, Hsu, Joseph R., Karunakar, Madhav A., Kempton, Laurence B., Seymour, Rachel B., Sims, Stephen H., Churchill, Christine, Reilly, Rachel M., Zura, Robert D., Howes, Cameron, Mir, Hassan, Wagstrom, Emily A., Mullis, Brian, Anglen, Jeffrey O., Mullis, Leilani S., Shively, Karl D., Gaski, Greg E., Natoli, Roman M., Sorkin, Anthony, Virkus, Walter, Hymes, Robert A., Holzman, Michael A., Malekzadeh, A. Stephen, Schulman, Jeff E., Schwartzbach, Cary C., Lee, Olivia C., Krause, Peter C., Morandi, Massimo 'Max', Choo, Andrew, Munz, John W., Boutte, Sterling, Galpin, Matthew C., Frisch, H. Michael, Kaufman, Adam M., LeCroy, C. Michael, Smith, Christopher S., Stall, Alec C., Horne, Andrea, Nascone, Jason W., OʼHara, Nathan N., Paryavi, Ebrahim, Sciadini, Marcus F., Degani, Yasmin, Howe, Andrea L., Hayda, Roman, Evans, Andrew R., Sietsema, Debra L., Stawicki, Stanislaw P., Wojda, Thomas, Gardner, Michael J., Bishop, Julius A., Rehman, Saqib, Caroom, Cyrus, Sheridan, Elizabeth, Miclau, Theodore, Morshed, Saam, Higgins, Thomas F., Haller, Justin M., Matuszewski, Paul E., Aneja, Arun, Wright, Raymond D., Jr., Bergin, Patrick F., Bhanat, Eldrin, Graves, Matt L., Morellato, John, Spitler, Clay A., Teague, David, Ertl, William, Ahn, Jaimo, Hesketh, Patrick, Moloney, Gele B., Weinlein, John C., Zelle, Boris A., Agarwal, Animesh, Karia, Ravi A., Sathy, Ashoke, Sanders, Drew T., Weiss, David B., Yarboro, Seth R., Lester-Ballard, Veronica, McVey, Eric D., Dagal, Arman, Githens, Michael, Kleweno, Conor, Agel, Julie, Whiting, Paul S., Simske, Natasha M., Siy, Alexander B., Attum, Basem, Burgos, Eduardo, Gajari, Vamshi, Rodriguez-Buitrago, Andres, Sethi, Manish, Tummuru, Rajesh R., DʼAlleyrand, Jean-Claude G., Allen, Lauren E., Collins, Susan C., Huang, Yanjie, and Taylor, Tara J.
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- 2024
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13. Implementing stakeholder engagement to explore alternative models of consent: An example from the PREP-IT trials
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Pechero, Guillermo, Pfaff, Branden, Rao, Mayank, Pogorzelski, David, McKay, Paula, Spicer, Ella, Howe, Andrea, Demyanovich, Haley K, Sietsema, Debra L, McTague, Michael F, Ramsey, Lolita, Holden, Martha, Rudnicki, Joshua, Wells, Jeff, Medeiros, Michelle, Slobogean, Gerard P, Sprague, Sheila, Investigators, PREP-IT, Wells, Jeffrey, Bhandari, Mohit, Committee, Steering, D'Alleyrand, Jean-Claude, Harris, Anthony D, Mullins, Daniel C, Thabane, Lehana, Wood, Amber, Committee, Adjudication, Della Rocca, Gregory J, Hebden, Joan, Jeray, Kyle J, Marchand, Lucas, O'Hara, Lyndsay M, Zura, Robert, Committee, Data and Safety Monitoring, Gardner, Michael J, Blasman, Jenna, Davies, Jonah, Liang, Stephen, Taljaard, Monica, Core, Research Methodology, Devereaux, PJ, Guyatt, Gordon H, Heels-Ansdell, Diane, Core, Patient Centred Outcomes, Marvel, Debra, Palmer, Jana, Friedrich, Jeff, O'Hara, Nathan N, Grissom, Frances, Core, Orthopaedic Surgery, Gitajn, I Leah, Morshed, Saam, O'Toole, Robert V, Petrisor, Bradley A, Core, Room, Camara, Megan, Mossuto, Franca, Core, Infectious Disease, Joshi, Manjari G, Core, Fowler, Justin, Rivera, Jessica, Talbot, Max, Dodds, Shannon, Garibaldi, Alisha, Li, Silvia, Nguyen, Uyen, Rojas, Alejandra, Scott, Taryn, Del Fabbro, Gina, Szasz, Olivia Paige, Demyanovich, Haley, Little, Kelly, Mullins, C Daniel, Kettering, Eric, Hale, Diamond, Sites, PREP-IT Clinical, Eglseder, Andrew, Johnson, Aaron, Langhammer, Christopher, Lebrun, Christopher, Manson, Theodore, and Nascone, Jason
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Clinical Research ,Patient Safety ,Clinical Trials and Supportive Activities ,Health and social care services research ,8.4 Research design and methodologies (health services) ,PREP-IT Investigators ,Steering Committee ,Adjudication Committee ,Data and Safety Monitoring Committee ,Research Methodology Core ,Patient Centred Outcomes Core ,Orthopaedic Surgery Core ,Operating Room Core ,Infectious Disease Core ,Military Core ,PREP-IT Clinical Sites ,Aqueous-PREP and PREPARE ,Aqueous-PREP ,PREPARE ,Cluster randomized crossover ,Consent ,Deferred consent ,Patient advisors ,Stakeholder engagement ,Trial design - Abstract
IntroductionCluster randomized crossover trials are often faced with a dilemma when selecting an optimal model of consent, as the traditional model of obtaining informed consent from participant's before initiating any trial related activities may not be suitable. We describe our experience of engaging patient advisors to identify an optimal model of consent for the PREP-IT trials. This paper also examines surrogate measures of success for the selected model of consent.MethodsThe PREP-IT program consists of two multi-center cluster randomized crossover trials that engaged patient advisors to determine an optimal model of consent. Patient advisors and stakeholders met regularly and reached consensus on decisions related to the trial design including the model for consent. Patient advisors provided valuable insight on how key decisions on trial design and conduct would be received by participants and the impact these decisions will have.ResultsPatient advisors, together with stakeholders, reviewed the pros and cons and the requirements for the traditional model of consent, deferred consent, and waiver of consent. Collectively, they agreed upon a deferred consent model, in which patients may be approached for consent after their fracture surgery and prior to data collection. The consent rate in PREP-IT is 80.7%, and 0.67% of participants have withdrawn consent for participation.DiscussionInvolvement of patient advisors in the development of an optimal model of consent has been successful. Engagement of patient advisors is recommended for other large trials where the traditional model of consent may not be optimal.
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- 2021
14. Do-Not-Resuscitate status is an independent risk factor for medical complications and mortality among geriatric patients sustaining hip fractures
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Bosch, Liam C, Nathan, Karthik, Lu, Laura Y, Campbell, Sean T, Gardner, Michael J, and Bishop, Julius A
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Biomedical and Clinical Sciences ,Clinical Sciences ,Patient Safety ,Physical Injury - Accidents and Adverse Effects ,Aging ,Clinical Research ,6.4 Surgery ,Evaluation of treatments and therapeutic interventions ,Musculoskeletal ,Code status ,DNR ,Do-not-resuscitate ,Hip fracture ,Mortality ,Clinical sciences - Abstract
BackgroundThe purpose of this study was to compare outcomes after hip fracture surgery between DNR/DNI and full code cohorts to determine whether DNR/DNI status is an independent predictor of complications and mortality within one year. A significant number of geriatric hip fracture patients carry a code status designation of DNR/DNI (Do-Not-Resuscitate/Do-Not-Intubate). There is limited data addressing how this designation may influence prognosis.MethodsA retrospective chart review of all geriatric hip fractures treated between 2002 and 2017 at a single level-I academic trauma center was performed. 434 patients were eligible for this study with 209 in the DNR/DNI cohort and 225 in the full code cohort. The independent variable was code-status and dependent variables included patient demographics, surgery performed, American Society of Anesthesiologists, score, Charlson Comorbidity Index, significant medical and surgical complications within one year of surgery, duration of follow-up by an orthopaedic surgeon, duration of follow-up by any physician, and mortality within 1 year of surgery. One-year complication rates were compared, and multiple logistic regression analyses were performed to analyze the relationship between independent and dependent variables.ResultsThe DNR/DNI cohort experienced significantly more surgical complications compared to the full code cohort (14.8% vs 7.6%, p = 0.024). There was a significantly higher rate of medical complications and mortality in the DNR/DNI cohort (57.9% vs 36%, p
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- 2021
15. Managing work flow in high enrolling trials: The development and implementation of a sampling strategy in the PREPARE trial
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Pogorzelski, David, Nguyen, Uyen, McKay, Paula, Thabane, Lehana, Camara, Megan, Ramsey, Lolita, Seymour, Rachel, Goodman, J Brett, McGee, Sheketha, Fraifogl, Joanne, Hudgins, Andrea, Tanner, Stephanie L, Bhandari, Mohit, Slobogean, Gerard P, Sprague, Sheila, Committee:, on behalf of the PREP-IT Investigators Executive, Wells, Jeffrey, Committee, Steering, D'Alleyrand, Jean-Claude, Harris, Anthony D, Mullins, Daniel C, Wood, Amber, Committee, Adjudication, Della Rocca, Gregory J, Hebden, Joan, Jeray, Kyle J, Marchand, Lucas, O'Hara, Lyndsay M, Zura, Robert, Committee, Data and Safety Monitoring, Gardner, Michael J, Blasman, Jenna, Davies, Jonah, Liang, Stephen, Taljaard, Monica, Core, Research Methodology, Devereaux, PJ, Guyatt, Gordon H, Heels-Ansdell, Diane, Core, Patient Centred Outcomes, Marvel, Debra, Palmer, Jana, Friedrich, Jeff, O'Hara, Nathan N, Grissom, Frances, Core, Orthopaedic Surgery, Gitajn, I Leah, Morshed, Saam, O'Toole, Robert V, Petrisor, Bradley A, Core, Room, Mossuto, Franca, Core, Infectious Disease, Joshi, Manjari G, Core, Fowler, Justin, Rivera, Jessica, Talbot, Max, Center, McMaster University Methods, Dodds, Shannon, Garibaldi, Alisha, Li, Silvia, Rojas, Alejandra, Scott, Taryn, Del Fabbro, Gina, Szasz, Olivia Paige, Center, University of Maryland School of Medicine Administrative, Howe, Andrea, Rudnicki, Joshua, Demyanovich, Haley, Little, Kelly, School of Pharmacy, The PATIENTS Program University of Maryland, Mullins, C Daniel, Medeiros, Michelle, Kettering, Eric, Hale, Diamond, Site, PREP-IT Clinical Sites Lead Clinical, Eglseder, Andrew, Johnson, Aaron, Langhammer, Christopher, Lebrun, Christopher, Manson, Theodore, Nascone, Jason, Paryavi, Ebrahim, and Pensy, Raymond
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Health Services ,Clinical Trials and Supportive Activities ,Clinical Research ,Good Health and Well Being ,PREP-IT Investigators Executive Committee: ,Steering Committee ,Adjudication Committee ,Data and Safety Monitoring Committee ,Research Methodology Core ,Patient Centred Outcomes Core ,Orthopaedic Surgery Core ,Operating Room Core ,Infectious Disease Core ,Military Core ,McMaster University Methods Center ,University of Maryland School of Medicine Administrative Center ,University of Maryland School of Pharmacy ,The PATIENTS Program ,PREP-IT Clinical Sites: Lead Clinical Site ,Aqueous-PREP and PREPARE ,Aqueous-PREP ,PREPARE ,PREP-IT Investigators Executive Committee ,Cluster crossover ,Pragmatic ,Sampling ,Sampling framework ,Sampling strategy ,Work flow - Abstract
IntroductionPragmatic trials in comparative effectiveness research assess the effects of different treatment, therapeutic, or healthcare options in clinical practice. They are characterized by broad eligibility criteria and large sample sizes, which can lead to an unmanageable number of participants, increasing the risk of bias and affecting the integrity of the trial. We describe the development of a sampling strategy tool and its use in the PREPARE trial to circumvent the challenge of unmanageable work flow.MethodsGiven the broad eligibility criteria and high fracture volume at participating clinical sites in the PREPARE trial, a pragmatic sampling strategy was needed. Using data from PREPARE, descriptive statistics were used to describe the use of the sampling strategy across clinical sites. A Chi-square test was performed to explore whether use of the sampling strategy was associated with a reduction in the number of missed eligible patients.Results7 of 20 clinical sites (35%) elected to adopt a sampling strategy. There were 1539 patients excluded due to the use of the sampling strategy, which represents 30% of all excluded patients and 20% of all patients screened for participation. Use of the sampling strategy was associated with lower odds of missed eligible patients (297/4545 (6.5%) versus 341/3200 (10.7%) p
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- 2021
16. Postoperative sepsis and septic shock after hip fracture surgery
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Gonzalez, Christian A, O'Mara, Alana, Cruz, Jacquelyn P, Roth, Dylan, Van Rysselberghe, Noelle L, and Gardner, Michael J
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- 2023
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17. Biomechanical analysis of recently released cephalomedullary nails for trochanteric femoral fracture fixation in a human cadaveric model
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Pastor, Torsten, Zderic, Ivan, Gehweiler, Dominic, Gardner, Michael J., Stoffel, Karl, Richards, Geoff, Knobe, Matthias, and Gueorguiev, Boyko
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- 2022
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18. The impact of heterotopic ossification prophylaxis after surgical fixation of acetabular fractures: national treatment patterns and related outcomes
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Slobogean, Gerard P., Sprague, Sheila, Wells, Jeffrey, Bhandari, Mohit, Harris, Anthony D., Mullins, C. Daniel, Thabane, Lehana, Wood, Amber, Rocca, Gregory J. Della, Hebden, Joan, Jeray, Kyle J., Marchand, Lucas S., O'Hara, Lyndsay M., Zura, Robert, Lee, Christopher, Patterson, Joseph, Gardner, Michael J., Blasman, Jenna, Davies, Jonah, Liang, Stephen, Taljaard, Monica, Devereaux, PJ, Guyatt, Gordon H., Heels-Ansdell, Diane, Marvel, Debra, Wells, Jana Palmer Jeffrey, Friedrich, Jeff, O'Hara, Nathan N., Grissom, Frances, Gitajn, I. Leah, Morshed, Saam, O'Toole, Robert V., Petrisor, Bradley A., Mossuto, Franca, Joshi, Manjari G., D'Alleyrand, Jean-Claude, Fowler, Justin, Rivera, Jessica, Talbot, Max, Pogorzelski, David, Dodds, Shannon, Li, Silvia, Rojas, Alejandra, Fabbro, Gina Del, Szasz, Olivia Paige, McKay, Paula, Minea, Alexandra, Howe, Andrea, Demyanovich, Haley, Medeiros, Michelle, Polk, Genevieve, Kettering, Eric, Mahal, Nirmen, Eglseder, Andrew, Johnson, Aaron, Langhammer, Christopher, Lebrun, Christopher, Nascone, Jason, Pensy, Raymond, Pollak, Andrew, Sciadini, Marcus, Degani, Yasmin, Demyanovich, Haley K., Phipps, Heather, Hempen, Eric, Holler, Christine, Petrisor, Brad A., Johal, Herman, Ristevski, Bill, Williams, Dale, Denkers, Matthew, Rajaratnam, Krishan, Al-Asiri, Jamal, Gallant, Jodi, Pusztai, Kaitlyn, MacRae, Sarah, Renaud, Sara, Adams, John D., Beckish, Michael L., Bray, Christopher C., Brown, Timothy R., Cross, Andrew W., Dew, Timothy, Faucher, Gregory K., Gurich, Richard W., Jr, Lazarus, David E., Millon, S. John, Moody, M. Christian, Palmer, M. Jason, Porter, Scott E., Schaller, Thomas M., Sridhar, Michael S., Sanders, John L., Rudisill, L. Edwin, Jr, Garitty, Michael J., Poole, Andrew S., Sims, Michael L., Walker, Clark M., Carlisle, Robert, Hofer, Erin A., Huggins, Brandon, Hunter, Michael, Marshall, William, Ray, Shea B., Smith, Cory, Altman, Kyle M., Pichiotino, Erin, Quirion, Julia C., Loeffler, Markus F., Pichiotino, Erin R., Cole, Austin A., Maltz, Ethan J., Parker, Wesley, Ramsey, T. Bennett, Burnikel, Alex, Colello, Michael, Stewart, Russell, Wise, Jeremy, Anderson, Matthew, Eskew, Joshua, Judkins, Benjamin, Miller, James M., Tanner, Stephanie L., Snider, Rebecca G., Townsend, Christine E., Pham, Kayla H., Martin, Abigail, Robertson, Emily, Bray, Emily, Sykes, J. Wilson, Yoder, Krystina, Conner, Kelsey, Abbott, Harper, Natoli, Roman M., McKinley, Todd O., Virkus, Walter W., Sorkin, Anthony T., Szatkowski, Jan P., Mullis, Brian H., Jang, Yohan, Lopas, Luke A., Hill, Lauren C., Fentz, Courteney L., Diaz, Maricela M., Brown, Krista, Garst, Katelyn M., Denari, Emma W., Osborn, Patrick, Pierrie, Sarah, Herrera, Maria, Miclau, Theodore, Marmor, Meir, Matityahu, Amir, McClellan, R. Trigg, Shearer, David, Toogood, Paul, Ding, Anthony, Murali, Jothi, Naga, Ashraf El, Tangtiphaiboontana, Jennifer, Belaye, Tigist, Berhaneselase, Eleni, Pokhvashchev, Dmitry, Obremskey, William T, Jahangir, Amir Alex, Sethi, Manish, Boyce, Robert, Stinner, Daniel J., Mitchell, Phillip, Trochez, Karen, Rodriguez, Elsa, Pritchett, Charles, Hogan, Natalie, Moreno, A. Fidel, Hagen, Jennifer E., Patrick, Matthew, Vlasak, Richard, Krupko, Thomas, Talerico, Michael, Horodyski, Marybeth, Pazik, Marissa, Lossada-Soto, Elizabeth, Gary, Joshua L., Warner, Stephen J, Munz, John W., Choo, Andrew M., Achor, Timothy S., Routt, Milton L. “Chip”, Kutzler, Michael, Boutte, Sterling, Warth, Ryan J., Prayson, Michael, Venkatarayappa, Indresh, Horne, Brandon, Jerele, Jennifer, Clark, Linda, Boulton, Christina, Lowe, Jason, Ruth, John T., Askam, Brad, Seach, Andrea, Cruz, Alejandro, Featherston, Breanna, Carlson, Robin, Romero, Iliana, Zarif, Isaac, Dehghan, Niloofar, McKee, Michael, Jones, Clifford B, Sietsema, Debra L, Williams, Alyse, Dykes, Tayler, Guerra-Farfan, Ernesto, Tomas-Hernandez, Jordi, Teixidor-Serra, Jordi, Molero-Garcia, Vicente, Selga-Marsa, Jordi, Porcel-Vazquez, Juan Antonio, Andres-Peiro, Jose Vicente, Esteban-Feliu, Ignacio, Vidal-Tarrason, Nuria, Serracanta, Jordi, Nuñez-Camarena, Jorge, del Mar Villar-Casares, Maria, Mestre-Torres, Jaume, Lalueza-Broto, Pilar, Moreira-Borim, Felipe, Garcia-Sanchez, Yaiza, Marcano-Fernández, Francesc, Martínez-Carreres, Laia, Martí-Garín, David, Serrano-Sanz, Jorge, Sánchez-Fernández, Joel, Sanz-Molero, Matsuyama, Carballo, Alejandro, Pelfort, Xavier, Acerboni-Flores, Francesc, Alavedra-Massana, Anna, Anglada-Torres, Neus, Berenguer, Alexandre, Cámara-Cabrera, Jaume, Caparros-García, Ariadna, Fillat-Gomà, Ferran, Fuentes-López, Ruben, Garcia-Rodriguez, Ramona, Gimeno-Calavia, Nuria, Martínez-Álvarez, Marta, Martínez-Grau, Patricia, Pellejero-García, Raúl, Ràfols-Perramon, Ona, Peñalver, Juan Manuel, Domènech, Mònica Salomó, Soler-Cano, Albert, Velasco-Barrera, Aldo, Yela-Verdú, Christian, Bueno-Ruiz, Mercedes, Sánchez-Palomino, Estrella, Andriola, Vito, Molina-Corbacho, Matilde, Maldonado-Sotoca, Yeray, Gasset-Teixidor, Alfons, Blasco-Moreu, Jorge, Fernández-Poch, Núria, Rodoreda-Puigdemasa, Josep, Verdaguer-Figuerola, Arnau, Cueva-Sevieri, Heber Enrique, Garcia-Gimenez, Santiago, Viskontas, Darius G., Apostle, Kelly L., Boyer, Dory S., Moola, Farhad O., Perey, Bertrand H., Stone, Trevor B., Lemke, H. Michael, Spicer, Ella, Payne, Kyrsten, Hymes, Robert A., Schwartzbach, Cary C., Schulman, Jeff E., Malekzadeh, A. Stephen, Holzman, Michael A., Gaski, Greg E., Wills, Jonathan, Pilson, Holly, Carroll, Eben A., Halvorson, Jason J., Babcock, Sharon, Goodman, J. Brett, Holden, Martha B., Williams, Wendy, Hill, Taylor, Brotherton, Ariel, Romeo, Nicholas M., Vallier, Heather A, Vergon, Anna, Higgins, Thomas F., Haller, Justin M., Rothberg, David L., Olsen, Zachary M., McGowan, Abby V., Hill, Sophia, Dauk, Morgan K., Bergin, Patrick F., Russell, George V., Graves, Matthew L., Morellato, John, McGee, Sheketha L., Bhanat, Eldrin L., Yener, Ugur, Khanna, Rajinder, Nehete, Priyanka, Potter, Dr. David, VanDemark, Dr. Robert, III, Seabold, Kyle, Staudenmier, Nicholas, Coe, Marcus, Dwyer, Kevin, Mullin, Devin S., Chockbengboun, Theresa A., DePalo, Peter A., Sr., Phelps, Kevin, Bosse, Michael, Karunakar, Madhav, Kempton, Laurence, Sims, Stephen, Hsu, Joseph, Seymour, Rachel, Churchill, Christine, Mayfield, Ada, Sweeney, Juliette, Jaeblon, Todd, Beer, Robert, Bauer, Brent, Meredith, Sean, Talwar, Sneh, Domes, Christopher M., Gage, Mark J., Reilly, Rachel M., Paniagua, Ariana, Dupree, JaNell, Weaver, Michael J., von Keudell, Arvind G., Sagona, Abigail E., Mehta, Samir, Donegan, Derek, Horan, Annamarie, Dooley, Mary, Heng, Marilyn, Harris, Mitchel B., Lhowe, David W., Esposito, John G., Alnasser, Ahmad, Shannon, Steven F., Scott, Alesha N., Clinch, Bobbi, Weber, Becky, Beltran, Michael J., Archdeacon, Michael T., Sagi, Henry Claude, Wyrick, John D., Le, Theodore Toan, Laughlin, Richard T., Thomson, Cameron G., Hasselfeld, Kimberly, Lin, Carol A., Vrahas, Mark S., Moon, Charles N., Little, Milton T., Marecek, Geoffrey S., Dubuclet, Denice M., Scolaro, John A., Learned, James R., Lim, Philip K., Demas, Susan, Amirhekmat, Arya, Dela Cruz, Yan Marco, Boissonneault, Adam, O Hara, Nathan, Marchand, Lucas, Higgins, Thomas, Gitajn, Leah, Sharma, Ishani, O’Toole, Robert V, and Slobogean, Gerard
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- 2023
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19. Delayed Union of a Diaphyseal Forearm Fracture Associated With Impaired Osteogenic Differentiation of Prospectively Isolated Human Skeletal Stem Cells
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Goodnough, L Henry, Ambrosi, Thomas H, Steininger, Holly, DeBaun, Malcolm R, Abrams, Geoffrey D, McAdams, Timothy R, Gardner, Michael J, Chan, Charles KF, and Bishop, Julius A
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Regenerative Medicine ,Physical Injury - Accidents and Adverse Effects ,Stem Cell Research ,Musculoskeletal ,BONE CELLS ,INJURY ,FRACTURE HEALING ,ORTHOPEDICS ,STROMAL ,STEM CELLS ,INJURY/FRACTURE HEALING ,STROMAL/STEM CELLS ,Biomedical and clinical sciences - Abstract
Delayed union or nonunion are relatively rare complications after fracture surgery, but when they do occur, they can result in substantial morbidity for the patient. In many cases, the etiology of impaired fracture healing is uncertain and attempts to determine the molecular basis for delayed union and nonunion formation have been limited. Prospectively isolating skeletal stem cells (SSCs) from fracture tissue samples at the time of surgical intervention represent a feasible methodology to determine a patient's biologic risk for compromised fracture healing. This report details a case in which functional in vitro readouts of SSCs derived from human fracture tissue at time of injury predicted a poor fracture healing outcome. This case suggests that it may be feasible to stratify a patient's fracture healing capacity and predict compromised fracture healing by prospectively isolating and analyzing SSCs during the index fracture surgery. © 2020 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
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- 2020
20. Geriatric fragility fractures are associated with a human skeletal stem cell defect
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Ambrosi, Thomas H, Goodnough, L Henry, Steininger, Holly M, Hoover, Malachia Y, Kim, Emiley, Koepke, Lauren S, Marecic, Owen, Zhao, Liming, Seita, Jun, Bishop, Julius A, Gardner, Michael J, and Chan, Charles KF
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Biochemistry and Cell Biology ,Biomedical and Clinical Sciences ,Biological Sciences ,Stem Cell Research - Nonembryonic - Human ,Regenerative Medicine ,Stem Cell Research - Nonembryonic - Non-Human ,Aging ,Stem Cell Research ,Musculoskeletal ,Adolescent ,Adult ,Adult Stem Cells ,Aged ,Aged ,80 and over ,Cell Differentiation ,Female ,Fractures ,Bone ,Geriatrics ,Humans ,Male ,Middle Aged ,Muscle ,Skeletal ,Young Adult ,aging ,bone healing ,geriatric fractures ,human skeletal stem cell ,sexual dimorphism ,Medical and Health Sciences ,Developmental Biology ,Biological sciences ,Biomedical and clinical sciences - Abstract
Fragility fractures have a limited capacity to regenerate, and impaired fracture healing is a leading cause of morbidity in the elderly. The recent identification of a highly purified bona fide human skeletal stem cell (hSSC) and its committed downstream progenitor cell populations provides an opportunity for understanding the mechanism of age-related compromised fracture healing from the stem cell perspective. In this study, we tested whether hSSCs isolated from geriatric fractures demonstrate intrinsic functional defects that drive impaired healing. Using flow cytometry, we analyzed and isolated hSSCs from callus tissue of five different skeletal sites (n = 61) of patients ranging from 13 to 94 years of age for functional and molecular studies. We observed that fracture-activated amplification of hSSC populations was comparable at all ages. However, functional analysis of isolated stem cells revealed that advanced age significantly correlated with reduced osteochondrogenic potential but was not associated with decreased in vitro clonogenicity. hSSCs derived from women displayed an exacerbated functional decline with age relative to those of aged men. Transcriptomic comparisons revealed downregulation of skeletogenic pathways such as WNT and upregulation of senescence-related pathways in young versus older hSSCs. Strikingly, loss of Sirtuin1 expression played a major role in hSSC dysfunction but re-activation by trans-resveratrol or a small molecule compound restored in vitro differentiation potential. These are the first findings that characterize age-related defects in purified hSSCs from geriatric fractures. Our results provide a foundation for future investigations into the mechanism and reversibility of skeletal stem cell aging in humans.
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- 2020
21. Indications for cement augmentation in fixation of geriatric intertrochanteric femur fractures: a systematic review of evidence
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Goodnough, L. Henry, Wadhwa, Harsh, Tigchelaar, Seth S., DeBaun, Malcolm R., Chen, Michael J., Graves, Matt L., and Gardner, Michael J.
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- 2022
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22. Subtrochanteric Femoral Nonunion
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Martin, Case W., primary and Gardner, Michael J., additional
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- 2023
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23. Drilling the cement mantle in well-fixed periprosthetic femur fractures is not associated with arthroplasty-related complications
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Van Rysselberghe, Noelle L., DeBaun, Malcolm R., Sanchez, Mark, Wadhwa, Harsh, Pfaff, Kayla E., Bellino, Michael J., Gardner, Michael J., and Bishop, Julius A.
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- 2022
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24. Biomechanically superior treatments do not translate into improved outcomes in randomized controlled trials
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Xiong, Grace X., Kang, Jason R., Sharma, Jigyasa, Finlay, Andrea, Gardner, Michael J., and Bishop, Julius A.
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- 2022
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25. Aqueous skin antisepsis before surgical fixation of open fractures (Aqueous-PREP): a multiple-period, cluster-randomised, crossover trial
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Slobogean, Gerard P., Sprague, Sheila, Wells, Jeffrey L., Bhandari, Mohit, Harris, Anthony D., Mullins, C. Daniel, Thabane, Lehana, Wood, Amber, Della Rocca, Gregory J., Hebden, Joan N., Jeray, Kyle J., Marchand, Lucas S., O'Hara, Lyndsay M., Zura, Robert D., Lee, Christopher, Patterson, Joseph T., Gardner, Michael J., Blasman, Jenna, Davies, Jonah, Liang, Stephen, Taljaard, Monica, Devereaux, PJ, Guyatt, Gordon, Heels-Ansdell, Diane, Marvel, Debra, Palmer, Jana E., Friedrich, Jeff, O'Hara, Nathan N., Grissom, Frances, Gitajn, I. Leah, Morshed, Saam, O'Toole, Robert V., Petrisor, Bradley, Mossuto, Franca, Joshi, Manjari G., D'Alleyrand, Jean-Claude G., Fowler, Justin, Rivera, Jessica C., Talbot, Max, Pogorzelski, David, Dodds, Shannon, Li, Silvia, Del Fabbro, Gina, Szasz, Olivia Paige, Bzovsky, Sofia, McKay, Paula, Minea, Alexandra, Murphy, Kevin, Howe, Andrea L., Demyanovich, Haley K., Hoskins, Wayne, Medeiros, Michelle, Polk, Genevieve, Kettering, Eric, Mahal, Nirmen, Eglseder, Andrew, Johnson, Aaron, Langhammer, Christopher, Lebrun, Christopher, Nascone, Jason, Pensy, Raymond, Pollak, Andrew, Sciadini, Marcus, Degani, Yasmin, Phipps, Heather, Hempen, Eric, Johal, Herman, Ristevski, Bill, Williams, Dale, Denkers, Matthew, Rajaratnam, Krishan, Al-Asiri, Jamal, Gallant, Jodi L., Pusztai, Kaitlyn, MacRae, Sarah, Renaud, Sara, Adams, John D., Beckish, Michael L., Bray, Christopher C., Brown, Timothy R., Cross, Andrew W., Dew, Timothy, Faucher, Gregory K., Gurich Jr, Richard W., Lazarus, David E., Millon, S. John, Moody, M. Christian, Palmer, M. Jason, Porter, Scott E., Schaller, Thomas M., Sridhar, Michael S., Sanders, John L., Rudisill Jr, L. Edwin, Garitty, Michael J., Poole, Andrew S., Sims, Michael L., Walker, Clark M., Carlisle, Robert, Hofer, Erin A., Huggins, Brandon, Hunter, Michael, Marshall, William, Ray, Shea B., Smith, Cory, Altman, Kyle M., Pichiotino, Erin R., Quirion, Julia C., Loeffler, Markus F., Cole, Austin A., Maltz, Ethan J., Parker, Wesley, Ramsey, T. Bennett, Burnikel, Alex, Colello, Michael, Stewart, Russell, Wise, Jeremy, Anderson, Matthew, Eskew, Joshua, Judkins, Benjamin, Miller, James M., Tanner, Stephanie L., Snider, Rebecca G., Townsend, Christine E., Pham, Kayla H., Martin, Abigail, Robertson, Emily, Bray, Emily, Sykes, J. Wilson, Yoder, Krystina, Conner, Kelsey, Abbott, Harper, Natoli, Roman M., McKinley, Todd O., Virkus, Walter W., Sorkin, Anthony T., Szatkowski, Jan P., Mullis, Brian H., Jang, Yohan, Lopas, Luke A., Hill, Lauren C., Fentz, Courteney L., Diaz, Maricela M., Brown, Krista, Garst, Katelyn M., Denari, Emma W., Osborn, Patrick, Pierrie, Sarah N., Kessler, Bradley, Herrera, Maria, Miclau, Theodore, Marmor, Meir T., Matityahu, Amir, McClellan, R. Trigg, Shearer, David, Toogood, Paul, Ding, Anthony, Murali, Jothi, El Naga, Ashraf, Tangtiphaiboontana, Jennifer, Belaye, Tigist, Berhaneselase, Eleni, Pokhvashchev, Dmitry, Obremskey, William T., Jahangir, Amir Alex, Sethi, Manish, Boyce, Robert, Stinner, Daniel J., Mitchell, Phillip P., Trochez, Karen, Rodriguez, Elsa, Pritchett, Charles, Hogan, Natalie, Fidel Moreno, A., Hagen, Jennifer E., Patrick, Matthew, Vlasak, Richard, Krupko, Thomas, Talerico, Michael, Horodyski, Marybeth, Pazik, Marissa, Lossada-Soto, Elizabeth, Gary, Joshua L., Warner, Stephen J., Munz, John W., Choo, Andrew M., Achor, Timothy S., Routt, Milton L. “Chip”, Kutzler, Michael, Boutte, Sterling, Warth, Ryan J., Prayson, Michael J., Venkatarayappa, Indresh, Horne, Brandon, Jerele, Jennifer, Clark, Linda, Boulton, Christina, Lowe, Jason, Ruth, John T., Askam, Brad, Seach, Andrea, Cruz, Alejandro, Featherston, Breanna, Carlson, Robin, Romero, Iliana, Zarif, Isaac, Dehghan, Niloofar, McKee, Michael, Jones, Clifford B., Sietsema, Debra L., Williams, Alyse, Dykes, Tayler, Guerra-Farfan, Ernesto, Tomas-Hernandez, Jordi, Teixidor-Serra, Jordi, Molero-Garcia, Vicente, Selga-Marsa, Jordi, Porcel-Vazquez, Juan Antonio, Andres-Peiro, Jose Vicente, Esteban-Feliu, Ignacio, Vidal-Tarrason, Nuria, Serracanta, Jordi, Nuñez-Camarena, Jorge, del Mar Villar-Casares, Maria, Mestre-Torres, Jaume, Lalueza-Broto, Pilar, Moreira-Borim, Felipe, Garcia-Sanchez, Yaiza, Marcano-Fernández, Francesc, Martínez-Carreres, Laia, Martí-Garín, David, Serrano-Sanz, Jorge, Sánchez-Fernández, Joel, Sanz-Molero, Matsuyama, Carballo, Alejandro, Pelfort, Xavier, Acerboni-Flores, Francesc, Alavedra-Massana, Anna, Anglada-Torres, Neus, Berenguer, Alexandre, Cámara-Cabrera, Jaume, Caparros-García, Ariadna, Fillat-Gomà, Ferran, Fuentes-López, Ruben, Garcia-Rodriguez, Ramona, Gimeno-Calavia, Nuria, Martínez-Álvarez, Marta, Martínez-Grau, Patricia, Pellejero-García, Raúl, Ràfols-Perramon, Ona, Peñalver, Juan Manuel, Salomó Domènech, Mònica, Soler-Cano, Albert, Velasco-Barrera, Aldo, Yela-Verdú, Christian, Bueno-Ruiz, Mercedes, Sánchez-Palomino, Estrella, Andriola, Vito, Molina-Corbacho, Matilde, Maldonado-Sotoca, Yeray, Gasset-Teixidor, Alfons, Blasco-Moreu, Jorge, Fernández-Poch, Núria, Rodoreda-Puigdemasa, Josep, Verdaguer-Figuerola, Arnau, Cueva-Sevieri, Heber Enrique, Garcia-Gimenez, Santiago, Viskontas, Darius G., Apostle, Kelly L., Boyer, Dory S., Moola, Farhad O., Perey, Bertrand H., Stone, Trevor B., Lemke, H. Michael, Spicer, Ella, Payne, Kyrsten, Hymes, Robert A., Schwartzbach, Cary C., Schulman, Jeff E., Malekzadeh, A. Stephen, Holzman, Michael A., Gaski, Greg E., Wills, Jonathan, Pilson, Holly, Carroll, Eben A., Halvorson, Jason J., Babcock, Sharon, Goodman, J. Brett, Holden, Martha B., Williams, Wendy, Hill, Taylor, Brotherton, Ariel, Romeo, Nicholas M., Vallier, Heather A., Vergon, Anna, Higgins, Thomas F., Haller, Justin M., Rothberg, David L., Olsen, Zachary M., McGowan, Abby V., Hill, Sophia, Dauk, Morgan K., Bergin, Patrick F., Russell, George V., Graves, Matthew L., Morellato, John, McGee, Sheketha L., Bhanat, Eldrin L., Yener, Ugur, Khanna, Rajinder, Nehete, Priyanka, Potter, David, VanDemark III, Robert, Seabold, Kyle, Staudenmier, Nicholas, Coe, Marcus, Dwyer, Kevin, Mullin, Devin S., Chockbengboun, Theresa A., DePalo Sr., Peter A., Phelps, Kevin, Bosse, Michael, Karunakar, Madhav, Kempton, Laurence, Sims, Stephen, Hsu, Joseph, Seymour, Rachel, Churchill, Christine, Mayfield, Ada, Sweeney, Juliette, Jaeblon, Todd, Beer, Robert, Bauer, Brent, Meredith, Sean, Talwar, Sneh, Domes, Christopher M., Gage, Mark J., Reilly, Rachel M., Paniagua, Ariana, Dupree, JaNell, Weaver, Michael J., von Keudell, Arvind G., Sagona, Abigail E., Mehta, Samir, Donegan, Derek, Horan, Annamarie, Dooley, Mary, Heng, Marilyn, Harris, Mitchel B., Lhowe, David W., Esposito, John G., Alnasser, Ahmad, Shannon, Steven F., Scott, Alesha N., Clinch, Bobbi, Weber, Becky, Beltran, Michael J., Archdeacon, Michael T., Sagi, Henry Claude, Wyrick, John D., Le, Theodore Toan, Laughlin, Richard T., Thomson, Cameron G., Hasselfeld, Kimberly, Lin, Carol A., Vrahas, Mark S., Moon, Charles N., Little, Milton T., Marecek, Geoffrey S., Dubuclet, Denice M., Scolaro, John A., Learned, James R., Lim, Philip K., Demas, Susan, Amirhekmat, Arya, and Dela Cruz, Yan Marco
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- 2022
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26. The impact of COVID-19 restrictions on participant enrollment in the PREPARE trial
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Gardner, Michael J., Blasman, Jenna, Davies, Jonah, Liang, Stephen, Taljaard, Monica, Pogorzelski, David, McKay, Paula, Weaver, Michael J., Jaeblon, Todd, Hymes, Robert A., Gaski, Greg E., Fraifogl, Joanne, Ahn, James S., Bzovsky, Sofia, Slobogean, Gerard, and Sprague, Sheila
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- 2022
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27. A framework to make PROMs relevant to patients: qualitative study of communication preferences of PROMs
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Lai, Cara H., Shapiro, Lauren M., Amanatullah, Derek F., Chou, Loretta B., Gardner, Michael J., Hu, Serena S., Safran, Marc R., and Kamal, Robin N.
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- 2022
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28. Tranexamic acid does not affect intraoperative blood loss or in-hospital outcomes after acetabular fracture surgery
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Wadhwa, Harsh, Tigchelaar, Seth S., Chen, Michael J., Koltsov, Jayme C. B., Bellino, Michael J., Bishop, Julius A., and Gardner, Michael J.
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- 2022
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29. External Fixator Usage and Delayed MRI Scans: A National Survey Study
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Van Rysselberghe, Noelle L., Fithian, Andrew T., Kim, Ho Bin, Sung, Jeffrey C., Chou, Benjamin B., Bishop, Julius A., Gardner, Michael J., Lucas, Justin F., and Hecht, Garin G.
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- 2023
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30. Mini-fragment plating of olecranon fractures is comparable to precontoured small-fragment plating
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Wadhwa, Harsh, Oquendo, Yousi A., Goodnough, L. Henry, DeBaun, Malcolm R., Bishop, Julius A., and Gardner, Michael J.
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- 2022
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31. Integrated Dual Lag Screws Have Higher Reoperation Rates for Fixation Failure Than Single Lag Component Cephalomedullary Nails: A Retrospective Study of 2,130 Patients with Intertrochanteric Femoral Fractures.
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Gonzalez, Christian A., Van Rysselberghe, Noelle L., Whittaker, Mathew J., Ngo, Daniel, Michaud, John B., and Gardner, Michael J.
- Abstract
Background: Previous studies comparing reoperation risk between integrated dual lag screw (IDL) and single lag component (SL) cephalomedullary nails (CMNs) in the treatment of intertrochanteric femoral fractures have demonstrated mixed results. The purpose of this study was to assess the rates of reoperation for fixation failure and all-cause reoperation in a large, multi-institutional cohort of patients with an intertrochanteric fracture treated with an IDL or SL CMN. We hypothesized that there would be no difference between the groups with respect to either of the reoperation rates. Methods: Adults (≥18 years old) who sustained an intertrochanteric fracture (AO/OTA 31A1 to 31A3) treated with an IDL or SL CMN between January 2014 and May 2021 at 1 of 13 Level-I trauma centers were included. Patients with <3 months of follow-up or pathologic fractures were excluded. Rates of reoperation were compared with use of the chi-square test and multivariable regression, controlling for age, gender, injury mechanism, fracture pattern, and postoperative neck-shaft angle. Results: A total of 2,130 patients met the inclusion criteria. The median age was 78 years, and 62.5% of patients were female. The cohort consisted of 287 patients (13.5%) with an IDL CMN and 1,843 patients (86.5%) with an SL CMN. A total of 99 patients (4.6%) had a reoperation of any type, of whom 29 (1.4% of all patients) had a reoperation for fixation failure. Compared with patients with an SL CMN, those with an IDL CMN had higher rates (4.2% versus 0.9%; p < 0.001) and odds (odds ratio [OR], 4.95 [95% confidence interval (CI), 2.29 to 10.69]; p < 0.001) of reoperation for fixation failure as well as higher rates (7.3% versus 4.2%; p = 0.021) and odds (OR, 1.83 [95% CI, 1.10 to 3.06]; p = 0.021) of all-cause reoperation. Conclusions: Intertrochanteric femoral fractures treated with an IDL CMN were associated with low but significantly higher rates and significantly higher odds of reoperation for fixation failure and all-cause reoperation compared with those treated with an SL CMN. We suggest caution to surgeons in the use of IDL CMNs for high-risk patients and recommend using SL CMNs for most patients with intertrochanteric femoral fractures. Level of Evidence: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence. [ABSTRACT FROM AUTHOR]
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- 2024
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32. Treatment Failure After Repair of Displaced Femoral Neck Fractures in Patients Compared by "Decade of Life": An Analysis of 565 Cases in Adults Less Than 60 years of Age.
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Collinge, Cory A., Giga, Kashmeera, Roser, Thomas, Lebus, George F., Beltran, Michael J., Crist, Brett, Sems, Stephen A., Gardner, Michael J., Sagi, H. Claude, Archdeacon, Michael T., Mir, Hassan R., Rodriguez-Buitrago, Andres, Mitchell, Phillip, and Tornetta III, Paul
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- 2024
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33. Femoral Neck Fractures With Associated Ipsilateral Femoral Shaft Fractures in Young Adults <50 Years Old: A Multicenter Comparison of 80 Cases Versus Isolated Femoral Neck Fractures.
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Rechter, Griffin R., Collinge, Cory A., Rechter, Alan J., Gardner, Michael J., Sagi, H. Claude, Archdeacon, Michael T., Mir, Hassan R., Rodriguez-Buitrago, Andres, Mitchell, Phillip, and Beltran, Michael T.
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- 2024
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34. Optimal Fixation Strategies for Displaced Femoral Neck Fractures in Patients 18-59 Years of Age: An Analysis of 565 Cases Treated at 26 Level 1 Trauma Centers.
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Roser, Tom, Collinge, Cory A., Giga, Kashmeera, Lebus, George F., Beltran, Michael J., Crist, Brett, Sems, Stephen A., Gardner, Michael J., Sagi, H. Claude, Archdeacon, Michael T., Mir, Hassan R., Rodriguez-Buitrago, Andres, Mitchell, Phillip, and Tornetta III, Paul
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- 2024
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35. A Pilot Program: Remote Summer Program to Improve Opportunity and Mentorship Among Underrepresented Students Pursuing Orthopaedic Surgery
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Hastings, Katherine G., Freiman, Halle D., Amanatullah, Derek F., Gardner, Michael J., Frick, Steven, and Shea, Kevin G.
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- 2022
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36. Locked Lateral Plating vs. Retrograde Nailing for Distal Femur Fractures: A Prospective Multicenter Randomized Trial
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Dunbar, Robert P, Egol, Kenneth A, Jones, Clifford B, Ertl, Jan P, Mullis, Brian, Perez, Edward, Collinge, Cory A, Ostrum, Robert, Humphrey, Catherine, Gardner, Michael J, Ricci, William M, Phieffer, Laura S, Teague, David, Ertl, William, Born, Christopher T, Zonno, Alan, Siegel, Jodi, Sagi, H Claude, Pollak, Andrew, Schmidt, Andrew H, Templeman, David, Sems, Andrew, Friess, Darin M, Pape, Hans-Christoph, Krieg, James C, and Tornetta, Paul, III
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- 2022
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37. Outcomes of Patients with Preoperative Thrombocytosis After Hip Fracture Surgery
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Gonzalez, Christian A., primary, Van Rysselberghe, Noelle L., additional, Maschhoff, Clayton, additional, and Gardner, Michael J., additional
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- 2024
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38. 3D Topographical Scanning for the Detection of Osteoporosis
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Maschhoff, Clayton W., primary, Oquendo, Yousi, additional, Michaud, John B., additional, Carey, David, additional, Jamero, Christopher, additional, Bishop, Julius A., additional, Jin, Christopher, additional, DeBaun, Malcolm, additional, and Gardner, Michael J., additional
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- 2024
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39. Posterior Calcaneal Tuberosity Fractures
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Avery, Matthew C., Gardner, Michael J., Adams, Mark R., editor, and Benirschke, Stephen K., editor
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- 2020
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40. Perioperative Laboratory Markers as Risk Factors for Surgical Site Infection After Elective Hand Surgery
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Zhuang, Thompson, Shapiro, Lauren M., Fogel, Nathaniel, Richard, Marc J., Gardner, Michael J., and Kamal, Robin N.
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- 2021
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41. Distal femoral fine wire traction assisted retrograde nailing of the femur
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Chen, Michael J., Avedian, Raffi S., Gardner, Michael J., and Bishop, Julius A.
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- 2021
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42. Cephalomedullary helical blade is independently associated with less collapse in intertrochanteric femur fractures than lag screws
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Goodnough, L. Henry, Wadhwa, Harsh, Tigchelaar, Seth S., Pfaff, Kayla, Heffner, Michael, Van Rysselberghe, Noelle, DeBaun, Malcolm R., Bishop, Julius A., and Gardner, Michael J.
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- 2021
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43. Management of the posterior wall fracture in associated both column fractures of the acetabulum
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Chen, Michael J., Hollyer, Ian, Wadhwa, Harsh, Tigchelaar, Seth S., Van Rysselberghe, Noelle L., Bishop, Julius A., Bellino, Michael J., and Gardner, Michael J.
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- 2021
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44. Cost minimization analysis of the treatment of olecranon fracture in elderly patients: a retrospective analysis
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Welch, Jessica M., Zhuang, Thompson, Shapiro, Lauren M., Gardner, Michael J., Xiao, Michelle, and Kamal, Robin N.
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- 2022
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45. Modern radial head arthroplasty for terrible triad fracture-dislocations: a retrospective case series with minimum 3-year follow-up
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Van Rysselberghe, Noelle L., Salazar, Brett, DeBaun, Malcolm R., Goodnough, L. Henry, Lucas, Justin F., Bishop, Julius A., and Gardner, Michael J.
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- 2021
- Full Text
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46. Type 1 diabetic Akita mice have low bone mass and impaired fracture healing
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Hu, Pei, McKenzie, Jennifer A., Buettmann, Evan G., Migotsky, Nicole, Gardner, Michael J., and Silva, Matthew J.
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- 2021
- Full Text
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47. Implementing stakeholder engagement to explore alternative models of consent: An example from the PREP-IT trials
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Slobogean, Gerard P., Bhandari, Mohit, Sprague, Sheila, D'Alleyrand, Jean-Claude, Harris, Anthony D., Mullins, Daniel C., Thabane, Lehana, Wells, Jeffrey, Wood, Amber, Della Rocca, Gregory J., Hebden, Joan, Jeray, Kyle J., Marchand, Lucas, O'Hara, Lyndsay M., Zura, Robert, Gardner, Michael J., Blasman, Jenna, Davies, Jonah, Liang, Stephen, Taljaard, Monica, Devereaux, P.J., Guyatt, Gordon H., Heels-Ansdell, Diane, Marvel, Debra, Palmer, Jana, Friedrich, Jeff, O'Hara, Nathan N., Grissom, Ms Frances, Gitajn, I. Leah, Morshed, Saam, O'Toole, Robert V., Petrisor, Bradley A., Camara, Megan, Mossuto, Franca, Joshi, Manjari G., Fowler, Justin, Rivera, Jessica, Talbot, Max, Dodds, Shannon, Garibaldi, Alisha, Li, Silvia, Nguyen, Uyen, Pogorzelski, David, Rojas, Alejandra, Scott, Taryn, Del Fabbro, Gina, Szasz, Olivia Paige, McKay, Paula, Howe, Andrea, Rudnicki, Joshua, Demyanovich, Haley, Little, Kelly, Mullins, C. Daniel, Medeiros, Michelle, Kettering, Eric, Hale, Diamond, Petrisor, Brad A., Johal, Herman, Ristevski, Bill, Williams, Dale, Denkers, Matthew, Rajaratnam, Krishan, Al-Asiri, Jamal, Leonard, Jordan, Marcano-Fernández, Francesc A., Gallant, Jodi, Persico, Federico, Gjorgjievski, Marko, George, Annie, Natoli, Roman M., Gaski, Greg E., McKinley, Todd O., Virkus, Walter W., Sorkin, Anthony T., Szatkowski, Jan P., Baele, Joseph R., Mullis, Brian H., Hill, Lauren C., Hudgins, Andrea, Osborn, Patrick, Pierrie, Sarah, Martinez, Eric, Kimmel, Joseph, Adams, John D., Beckish, Michael L., Bray, Christopher C., Brown, Timothy R., Cross, Andrew W., Dew, Timothy, Faucher, Gregory K., Gurich, Richard W., Jr., Lazarus, David E., Millon, S. John, Palmer, M. Jason, Porter, Scott E., Schaller, Thomas M., Sridhar, Michael S., Sanders, John L., Rudisill, L. Edwin, Jr., Garitty, Michael J., Poole, Andrew S., Sims, Michael L., Walker, Clark M., Carlisle, Robert M., II, Hofer, Erin Adams, Huggins, Brandon S., Hunter, Michael D., Marshall, William A., Ray, Shea Bielby, Smith, Cory D., Altman, Kyle M., Bedard, Julia C., Loeffler, Markus F., Pichiotino, Erin R., Cole, Austin A., Maltz, Ethan J., Parker, Wesley, Ramsey, T. Bennett, Burnikel, Alex, Colello, Michael, Stewart, Russell, Wise, Jeremy, Moody, M. Christian, Tanner, Stephanie L., Snider, Rebecca G., Townsend, Christine E., Pham, Kayla H., Martin, Abigail, Robertson, Emily, Miclau, Theodore, Kandemir, Utku, Marmor, Meir, Matityahu, Amir, McClellan, R. Trigg, Meinberg, Eric, Shearer, David, Toogood, Paul, Ding, Anthony, Donohoe, Erin, Murali, Jothi, Belaye, Tigist, Berhaneselase, Eleni, Paul, Alexandra, Garg, Kartik, Gary, Joshua L., Warner, Stephen J., Munz, John W., Choo, Andrew M., Achor, Timothy S., “Chip” Routt, Milton L., Rao, Mayank, Pechero, Guillermo, Miller, Adam, Hagen, Jennifer E., Patrick, Matthew, Vlasak, Richard, Krupko, Thomas, Sadasivan, Kalia, Koenig, Chris, Bailey, Daniel, Wentworth, Daniel, Van, Chi, Schwartz, Justin, Dehghan, Niloofar, Jones, Clifford B., Tracy Watson, J., McKee, Michael, Karim, Ammar, Talerico, Michael, Sietsema, Debra L., Williams, Alyse, Dykes, Tayler, Obremskey, William T., Jahangir, Amir Alex, Sethi, Manish, Boyce, Robert, Stinner, Daniel J., Mitchell, Phillip, Trochez, Karen, Rodriguez, Andres, Gajari, Vamshi, Rodriguez, Elsa, Pritchett, Charles, Boulton, Christina, Lowe, Jason, Wild, Jason, Ruth, John T., Taylor, Michel, Seach, Andrea, Saeed, Sabina, Culbert, Hunter, Cruz, Alejandro, Knapp, Thomas, Hurkett, Colin, Lowney, Maya, Prayson, Michael, Venkatarayappa, Indresh, Horne, Brandon, Jerele, Jennifer, Clark, Linda, Marcano-Fernández, Francesc, Jornet-Gibert, Montsant, Martínez-Carreres, Laia, Martí-Garín, David, Serrano-Sanz, Jorge, Sánchez-Fernández, Joel, Sanz-Molero, Matsuyama, Carballo, Alejandro, Pelfort, Xavier, Acerboni-Flores, Francesc, Alavedra-Massana, Anna, Anglada-Torres, Neus, Berenguer, Alexandre, Cámara-Cabrera, Jaume, Caparros-García, Ariadna, Fillat-Gomà, Ferran, Fuentes-López, Ruben, Garcia-Rodriguez, Ramona, Gimeno-Calavia, Nuria, Graells-Alonso, Guillem, Martínez-Álvarez, Marta, Martínez-Grau, Patricia, Pellejero-García, Raúl, Ràfols-Perramon, Ona, Peñalver, Juan Manuel, Domènech, Mònica Salomó, Soler-Cano, Albert, Velasco-Barrera, Aldo, Yela-Verdú, Christian, Bueno-Ruiz, Mercedes, Sánchez-Palomino, Estrella, Guerra-Farfan, Ernesto, Tomas-Hernandez, Jordi, Teixidor-Serra, Jordi, Molero-Garcia, Vicente, Selga-Marsa, Jordi, Porcel-Vasquez, Juan Antonio, Andres-Peiro, Jose Vicente, Minguell-Monyart, Joan, Garcia-Sanchez, Yaiza, Nuñez-Camarena, Jorge, Tauste-Rubio, Eladia, Gonzalez-Amigo, Marta, Romeo, Nicholas M., Vallier, Heather A., Breslin, Mary A., Fraifogl, Joanne, Wilson, Eleanor S., Wadenpfuhl, Leanne K., Halliday, Paul G., Viskontas, Darius G., Apostle, Kelly L., Boyer, Dory S., Moola, Farhad O., Perey, Bertrand H., Stone, Trevor B., Lemke, H. Michael, Zomar, Mauri, Spicer, Ella, Fan, Chen “Brenda”, Payne, Kyrsten, Phelps, Kevin, Bosse, Michael, Karunakar, Madhav, Kempton, Laurence, Sims, Stephen, Hsu, Joseph, Seymour, Rachel, Churchill, Christine, Bartel, Claire, Mayberry, Robert Miles, Brownrigg, Maggie, Girardi, Cara, Mayfield, Ada, Hymes, Robert A., Schwartzbach, Cary C., Schulman, Jeff E., Malekzadeh, A. Stephen, Holzman, Michael A., Ramsey, Lolita, Ahn, James S., Panjshiri, Farhanaz, Das, Sharmistha, English, Antoinisha D., Haaser, Sharon M., Cuff, Jaslynn A.N., Pilson, Holly, Carroll, Eben A., Halvorson, Jason J., Babcock, Sharon, Goodman, J. Brett, Holden, Martha B., Bullard, Debra, Williams, Wendy, Higgins, Thomas F., Haller, Justin M., Rothberg, David L., Marchand, Lucas S., Neese, Ashley, Russell, Mark, Olsen, Zachary M., Coe, Marcus, Dwyer, Kevin, Mullin, Devin S., Reilly, Clifford A., DePalo, Peter, Hall, Amy E., Heng, Marilyn, Harris, Mitchel B., Smith, R. Malcolm, Lhowe, David W., Esposito, John G., Bansal, Mira, Bergin, Patrick F., Russell, George V., Graves, Matthew L., Morellato, John, Champion, Heather K., Johnson, Leslie N., McGee, Sheketha L., Bhanat, Eldrin L., Mehta, Samir, Donegan, Derek, Ahn, Jaimo, Horan, Annamarie, Dooley, Mary, Kuczinski, Ashley, Iwu, Ashley, Potter, David, VanDemark, Robert, III, Pfaff, Branden, Hollinsworth, Troy, Weaver, Michael J., von Keudell, Arvind G., McTague, Michael F., Allen, Elizabeth M., Jaeblon, Todd, Beer, Robert, Demyanovich, Haley K., Gage, Mark J., Reilly, Rachel M., Sparrow, Cindy, Pechero, Guillermo, Jr., Holden, Martha, Wells, Jeff, Eglseder, Andrew, Johnson, Aaron, Langhammer, Christopher, Lebrun, Christopher, Manson, Theodore, Nascone, Jason, Paryavi, Ebrahim, Pensy, Raymond, Pollak, Andrew, Sciadini, Marcus, Degani, Yasmin, and Joseph, Katherine
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- 2021
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48. Contributors
- Author
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Achenbach, Leonard, primary, Adams, Julie, additional, Adams, Nicholas S., additional, McClees Aldridge, Julian, additional, Altman, Kyle M., additional, Amaro, Emilie J., additional, Antosh, Ivan, additional, Arrington, Edward, additional, Aversano, Francis J., additional, Azimi, Hassan J., additional, Barlow, Jonathan, additional, Berthold, Daniel P., additional, Boe, Chelsea C., additional, Bonazza, Nicholas A., additional, Brogan, David M., additional, Bruni, David F., additional, Calfee, Ryan P., additional, Catalano, Louis W., additional, Christie, Brian, additional, Christopherson, Zachary, additional, Cohen, Joseph B., additional, Cohn, Matthew R., additional, Cole, Brian J., additional, Cole, Peter A., additional, Cornelis, Bert, additional, Cregar, William M., additional, Cvetanovich, Gregory L., additional, Danford, Nicholas C., additional, Dantzker, Nicholas J., additional, DeBaun, Malcolm R., additional, De Wilde, Lieven, additional, Desai, Mihir J., additional, Edwards, Scott G., additional, Eglseder, Andy, additional, Elrick, Bryant P., additional, Evans, Peter J., additional, Faucher, Gregory K., additional, Fernandez, John J., additional, Finley, Zachary J., additional, Fogel, Nathaniel, additional, Foruria, Antonio M., additional, Frantz, Travis L., additional, Fu, Michael C., additional, Gardner, Michael J., additional, Gaston, R. Glenn, additional, Geissler, William B., additional, Gilat, Ron, additional, Gillespie, Robert J., additional, Gillis, Joshua A., additional, Goodnough, L. Henry, additional, Grier, Jordan, additional, Hammert, Warren C., additional, Hatzidakis, Armodios M., additional, Haunschild, Eric D., additional, Hess, Daniel E., additional, Hochreiter, Bettina, additional, Honig, Rachel, additional, Hoyen, Harry A., additional, Huang, Jerry I., additional, Hughes, Thomas B., additional, Jankowski, Jaclyn M., additional, Jeffcoat, Devon, additional, Johnson, Pierce, additional, Jost, Bernhard, additional, Kakar, Sanjeev, additional, Kamal, Robin, additional, Kaufmann, Robert A., additional, Kennedy, June, additional, Kremen, Thomas J., additional, Kuhn, John E., additional, Lafosse, Laurent, additional, Lafosse, Thibault, additional, Langhammer, Chris, additional, Liporace, Frank A., additional, London, Daniel A., additional, Maheshwer, Bhargavi, additional, Maslow, Jed I., additional, Maziak, Nina, additional, Mazzocca, Augustus D., additional, McKee, Michael, additional, Mengers, Sunita, additional, Millett, Peter J., additional, Moody, M. Christian, additional, Morrey, Mark E., additional, Nakashian, Michael N., additional, Neviaser, Andrew, additional, Nicholson, Gregory, additional, Nicholson, Luke T., additional, Nolte, Philip C., additional, O’Brien, Michael J., additional, O’Donnell, Marc J., additional, Omid, Reza, additional, Orbay, Jorge L., additional, O’Shaughnessy, Maureen, additional, Osterman, A. Lee, additional, Mayo, Belén Pardos, additional, Piper, Christine C., additional, Pitcher, Austin A., additional, Potter, David, additional, Rasuli, Kevin, additional, Reichel, Lee M., additional, Riboh, Jonathan C., additional, Ring, David, additional, Rizzo, Marco, additional, Ruch, David, additional, Russo, Frank A., additional, Sabbag, Casey, additional, Sanchez-Sotelo, Joaquin, additional, Savoie, Felix H., additional, Scheibel, Markus, additional, Schroder, BSME, Lisa K., additional, Sears, Benjamin W., additional, Singh, Anshu, additional, Spross, Christian, additional, Srinivasan, Ramesh C., additional, Steinmann, Scott, additional, Tabeayo, Eloy, additional, Tarr, Ryan, additional, Tauro, Tracy, additional, Tavakolian, Paul A., additional, Tokish, John M., additional, Tosti, Rick, additional, Tu, Leigh-Anne, additional, Uyeki, Colin L., additional, Van Tongel, Alexander, additional, Veltre, David R., additional, Verma, Nikhil N., additional, Walker, J. Brock, additional, Watts, Adam C., additional, Williams, Brady T., additional, Williams, Joel C., additional, Wilson, David, additional, Wolfson, Theodore S., additional, Wysocki, Robert W., additional, Yao, Jeffrey, additional, and Yoon, Richard S., additional
- Published
- 2022
- Full Text
- View/download PDF
49. Technique Spotlight
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Goodnough, L. Henry, primary, Debaun, Malcolm R., additional, and Gardner, Michael J., additional
- Published
- 2022
- Full Text
- View/download PDF
50. Metaphyseal callus formation in pilon fractures is associated with loss of alignment: Is stiffer better?
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Van Rysselberghe, Noelle L., Campbell, Sean T., Goodnough, L. Henry, Salazar, Brett P., Bishop, Julius A., Bellino, Michael J., Lucas, Justin F., and Gardner, Michael J.
- Published
- 2021
- Full Text
- View/download PDF
Catalog
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