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213 results on '"Gardner-Thorpe C"'

1. Spinocerebellar ataxia type 11

Author

Giunti, P., primary, Houlden, H., additional, Gardner-Thorpe, C., additional, Worth, P.F., additional, Johnson, J., additional, Hilton, D.A., additional, Revesz, T., additional, Davis, M.B., additional, and Wood, N.W., additional more...

Published
2012
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2. Autosomal dominant cerebellar ataxia type III: Linkage in a large British family to a 7.6-cM region on chromosome 15q14-21.3

Author

Worth, P.F., Giunti, P., Gardner-Thorpe, C., Diwon, P.H., Davis, M.B., and Wood, N.W.

Subjects
Genetic disorders -- Research, Chromosome mapping -- Usage, Cerebellar ataxia -- Genetic aspects, Biological sciences
Abstract

Autosomal dominant cerebellar ataxia type III (ADCA III), a fairly benign, slowly progressive, late-onset, neurological disorder, has been shown to be linked in a large British family to a 7.6-cM region on chromosome 15q14-21.3. The results of a genomewide seach show that there are two additional ADCA III loci and define the genetic heterogeneity of the disorder more clearly. more...

Published
1999

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8. Upholstererʼs PIN

Author

WILSON, S M, DEVARAJ, V, and GARDNER-THORPE, C

Published
2001

13. 10-year stroke prevention after successful carotid endarterectomy for asymptomatic stenosis (ACST-1): a multicentre randomised trial

Author

Halliday, A, Harrison, M, Hayter, E, Kong, X, Mansfield, A, Marro, J, Pan, H, Peto, R, Potter, J, Rahimi, K, Rau, A, Robertson, S, Streifler, J, Thomas, D, Fraedrich G, Asymptomatic Carotid Surgery Trial Collaborative G. r. o. u. p., Schmidauer, C, Hölzenbein, Th, Huk, I, Haumer, M, Kretschmer, G, Metz, V, Polterauer, P, Teufelsbauer, H, Cras, P, Hendriks, J, Lauwers, P, Van Schil, P, de Souza EB, Dourado, Me, Gurgel, G, Rocha, Gm, Petrov, V, Slabakov, G, Cooper, Me, Gubitz, G, Holness, R, Howes, W, Langille, R, Legg, K, Nearing, S, Mackean, G, Mackay, M, Phillips, Sj, Sullivan, J, Wood, J, Erdelez, L, Sosa, T, Angelides, Ns, Christopoulos, G, Malikidou, A, Pesta, A, Ambler, Z, Mracek, J, Polivka, J, Rohan, V, Sevcik, P, Simaná, J, Benes, V, Kramár, F, Kaste, M, Lepäntalo, M, Soinne, L, Cardon, Jm, Legalou, A, Gengenbach, B, Pfadenhauer, K, Wölfl, Kd, Flessenkämper, I, Klumpp, Bf, Marsch, J, Kolvenbach, R, Pfeiff, T, Sandmann, W, Beyersdorf, F, Hetzel, A, Sarai, K, Schöllhorn, J, Spillner, G, Lutz, Hj, Böckler, D, Maeder, N, Busse, O, Grönniger, J, Haukamp, F, Balzer, K, Knoob, Hg, Roedig, G, Virreira, L, Franke, S, Moll, R, Schneider, J, Dayantas, J, Sechas, Mn, Tsiaza, S, Kiskinis, D, Apor, A, Dzinich, C, Entz, L, Hüttl, K, Jàrànyi, Z, Mogan, I, Nagy, Z, Szabo, A, Varga, D, Juhász, G, Mátyás, L, Hutchinson, M, Mehigan, D, Aladjem, Z, Harah, E, Elmakias, S, Gurvich, D, Yoffe, B, Ben Meir, H, Dagan, L, Karmeli, R, Keren, G, Shimony, A, Weller, B, Avrahami, R, Koren, R, Streifler, Jy, Tabachnik, S, Zelikovski, A, Angiletta, D, Federico, F, Impedovo, G, Marotta, V, Pascazio, L, Regina, G, Andreoli, A, Pozzati, E, Bonardelli, S, Giulini, Sm, Guarneri, B, Caiazzo, P, Mascoli, F, Becchi, G, Masini, R, Santoro, E, Simoni, G, Ventura, M, Scarpelli, P, Spartera, C, Arena, O, Collice, M, Puttini, M, Romani, F, Santilli, I, Segramora, V, Sterzi, R, Deriu, G, Verlato, F, Cao, Pg, Cieri, Enrico, De Rango, P, Moggi, L, Ricci, S, Antico, A, Spigonardo, F, Malferrari, G, Tusini, N, Vecchiati, E, Cavallaro, A, Kasemi, H, Marino, M, Sbarigia, E, Speziale, F, Zinicola, N, Alò, Fp, Bartolini, M, Carbonari, L, Caporelli, S, Grili Cicilioni, C, Lagalla, G, Ioannidis, G, Pagliariccio, G, Silvestrini, M, Palombo, D, Peinetti, F, Adovasio, R, Chiodo Grandi, F, Mase, G, Zamolo, F, Fregonese, V, Gonano, N, Mozzon, L, Blair, R, Chuen, J, Ferrar, D, Garbowski, M, Hamilton, Mj, Holdaway, C, Muthu, S, Shakibaie, F, Vasudevan, Tm, Kroese, A, Slagsvold, Ce, Dahl, T, Johnsen, Hj, Lange, C, Myhre, Ho, Gniadek, J, Andziak, P, Elwertowski, M, Leszczynski, J, Malek, Ak, Mieszkowski, J, Noszczyk, W, Szostek, M, Toutounchi, S, Correia, C, Pereira, Mc, Akchurin, Rs, Flis, V, Miksic, K, Stirn, B, Tetickovic, E, Cairols, M, Capdevila, Jm, Iborra Ortega, E, Obach, V, Riambau, V, Vidal Barraquer, F, Vila Coll, R, Diaz Vidal, E, Iglesias Negreia JI, Tovar Pardo, A, Iglesias, Rj, Alfageme, Af, Barba Velez, A, Estallo Laliena, L, Garcia Monco JC, Gonzalez, Lr, Corominas, C, Julia, J, Lozano, P, Marti Masso JF, Porta, Rm, Carrera, Ar, Gomez, J, Blomstrand, C, Gelin, J, Holm, J, Karlström, L, Mattsson, E, Bornhov, S, Dahlstrom, J, De Pedis, G, Jensen, Sm, Pärsson, H, Plate, G, Qvarfordt, P, Arvidsson, B, Brattström, L, Forssell, C, Potemkowski, A, Skiöldebrand, C, Stoor, P, Blomqvist, M, Calander, M, Lundgren, F, Almqvist, H, Norgren, L, Norrving, B, Ribbe, E, Thörne, J, Gottsäter, A, Mätzsch, T, Nilsson, Me, Lonsson, M, Stahre, B, Stenberg, B, Konrad, P, Jarl, L, Lundqvist, L, Olofsson, P, Rosfors, S, Swedenborg, J, Takolander, R, Bergqvist, D, Ljungman, C, Kniemeyer, Hw, Widmer, Mk, Kuster, R, Kaiser, R, Nagel, W, Sege, D, Weder, B, De Nie, J, Doelman, J, Yilmaz, N, Buth, J, Stultiens, G, Boiten, J, Boon, A, van der Linden, F, Busman, Dc, Sinnige, Ha, Yo, Ti, de Borst GJ, Eikelboom, Bc, Kappelle, Lj, Moll, F, Dortland, Rw, Westra, Te, Jaber, H, Manaa, J, Meftah, Rb, Nabil, Br, Sraieb, T, Bateman, D, Budd, J, Horrocks, M, Kivela, M, Shaw, L, Walker, R, D'Sa, Aa, Fullerton, K, Hannon, R, Hood, Jm, Lee, B, Mcguigan, K, Morrow, J, Reid, J, Soong, Cv, Simms, M, Baird, R, Campbell, M, Cole, S, Ferguson, It, Lamont, P, Mitchell, D, Sassano, A, Smith, Fc, Blake, K, Kirkpatrick, Pj, Martin, P, Turner, C, Clegg, Jf, Crosley, M, Hall, J, De Cossart, L, Edwards, P, Fletcher, D, Rosser, S, Mccollum, Pt, Davidson, D, Levison, R, Bradbury, Aw, Chalmers, Rt, Dennis, M, Murie, J, Ruckley, Cv, Sandercock, P, Campbell, Wb, Frankel, T, Gardner Thorpe, C, Gutowski, N, Hardie, R, Honan, W, Niblett, P, Peters, A, Ridler, B, Thompson, Jf, Bone, I, Welch, G, Grocott, Ec, Overstall, P, Aldoori, Mi, Dafalla, Be, Bryce, J, Clarke, C, Ming, A, Wilkinson, Ar, Bamford, J, Berridge, D, Scott, J, Abbott, Rj, Naylor, R, Harris, P, Humphrey, P, Adiseshiah, M, Aukett, M, Baker, D, Bishop, Cc, Boutin, A, Brown, M, Burke, P, Burnand, Kg, Colchester, A, Coward, L, Davies, Ah, Espasandin, M, Giddings, Ae, Hamilton, G, Judge, C, Kakkos, S, Mcguiness, C, Morris Vincent, P, Nicolaides, A, Padayachee, Ts, Riordan, H, Sullivan, E, Taylor, P, Thompson, M, Wolfe, Jh, Mccollum, Cn, O'Neill, Pa, Welsh, S, Barnes, J, Cleland, P, Davis, M, Gholkar, A, Jones, R, Jaykishnam, V, Mendelow, Ad, O'Connell, Je, Siddique, Ms, Stansby, G, Vivar, R, Ashley, S, Cosgrove, C, Gibson, J, Wilkins, Dc, Chant, Ad, Frankel, J, Shearman, Cp, Williams, J, Hall, G, Holdsworth, R, Davies, Jn, Mclean, B, Woodburn, Kr, Brown, G, Curley, P, Loizou, L, Chaturvedi, S, Diaz, F, Radak, D, Todorovic, Pr, Kamugasha, D, Baxter, A, Berry, C, Burrett, J, Collins, R, Crowther, J, Davies, C, Farrell, B, Godwin, J, Gray, R, Harwood, C, Hirt, L, Hope, C, Knight, S, Lay, M, Munday, A, Murawska, A, Peto, Cg, Radley, A, Richards, S., Cras, Patrick, van Schil, Paul, et al., Asymptomatic Carotid Surgery Trial (ACST) Collaborative Group, Halliday, A, Harrison, M, Hayter, E, Kong, X, Mansfield, A, Marro, J, Pan, H, Peto, R, Potter, J, Rahimi, K, Rau, A, Robertson, S, Streifler, J, Thomas, D, Adovasio, Roberto, and Asymptomatic Carotid Surgery Trial Collaborative, Group more...

Subjects
Male, Time Factors, medicine.medical_treatment, Kaplan-Meier Estimate, Carotid endarterectomy, Aged, 80 and over, Carotid Stenosis, Endarterectomy, Carotid, Female, Humans, Incidence, Middle Aged, Primary Prevention, Stroke, Treatment Outcome, Stroke/epidemiology, law.invention, Randomized controlled trial, law, Aged, 80 and over, Endarterectomy, Carotid, endarterectomy, Carotid Stenosis/mortality, Incidence (epidemiology), Carotid*/mortality, General Medicine, Carotid Stenosis | Internal Carotid Artery | Endarterectomy, medicine.symptom, medicine.medical_specialty, Asymptomatic, Internal medicine, asymptomatic carotid artery stenosi, medicine, asymptomatic carotid artery stenosis, business.industry, Carotid Stenosis/complications, Stroke/prevention & control, Perioperative, medicine.disease, Surgery, Stenosis, Human medicine, business
Abstract

SummaryBackgroundIf carotid artery narrowing remains asymptomatic (ie, has caused no recent stroke or other neurological symptoms), successful carotid endarterectomy (CEA) reduces stroke incidence for some years. We assessed the long-term effects of successful CEA.MethodsBetween 1993 and 2003, 3120 asymptomatic patients from 126 centres in 30 countries were allocated equally, by blinded minimised randomisation, to immediate CEA (median delay 1 month, IQR 0·3–2·5) or to indefinite deferral of any carotid procedure, and were followed up until death or for a median among survivors of 9 years (IQR 6–11). The primary outcomes were perioperative mortality and morbidity (death or stroke within 30 days) and non-perioperative stroke. Kaplan-Meier percentages and logrank p values are from intention-to-treat analyses. This study is registered, number ISRCTN26156392.Findings1560 patients were allocated immediate CEA versus 1560 allocated deferral of any carotid procedure. The proportions operated on while still asymptomatic were 89·7% versus 4·8% at 1 year (and 92·1% vs 16·5% at 5 years). Perioperative risk of stroke or death within 30 days was 3·0% (95% CI 2·4–3·9; 26 non-disabling strokes plus 34 disabling or fatal perioperative events in 1979 CEAs). Excluding perioperative events and non-stroke mortality, stroke risks (immediate vs deferred CEA) were 4·1% versus 10·0% at 5 years (gain 5·9%, 95% CI 4·0–7·8) and 10·8% versus 16·9% at 10 years (gain 6·1%, 2·7–9·4); ratio of stroke incidence rates 0·54, 95% CI 0·43–0·68, p more...

Published
2010
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14. A Historical Dictionary of Psychiatry

Author

Gardner-Thorpe, C.

Subjects
A Historical Dictionary of Psychiatry (Book) -- Book reviews, Books -- Book reviews, Health, Psychology and mental health
Published
2005

16. Groundwater: medicine by the glassful?

Author

Duffin, C.J., Moody, R.T.J., Gardner-Thorpe, C., Robins, N.S., Smedley, P.L., Duffin, C.J., Moody, R.T.J., Gardner-Thorpe, C., Robins, N.S., and Smedley, P.L.

Abstract

Knowledge of the healing properties of some groundwater sources has been passed down through the generations. A complex array of hydrogeological environments yields a rich and diverse range of chemical compositions, and cures for a variety of ailments were available from some spring waters. Many were sourced with associated religious overtones. It is likely that exposure to clean cold water alleviates the symptoms of leprosy and probable also that it relieves rheumatic pain. However, the only demonstrable medicinal properties of groundwater are its purging effects wherever MgSO4 or Epsom salts prevailed. Clean and potable groundwater is certainly a key to human health and some of the minerals dissolved within it are essential to the human body, although many of these minerals become toxic if present in excess. The modern fashion for bottled groundwater, often perceived to be associated with health-giving and medicinal properties, for the most part, merely offer a safe form of drinking water. The curative and medicinal properties of groundwater have been recognized, correctly or otherwise, for several thousands of years. The founding of the English city of Bath, with its well-known spa waters, goes back to 863 BC when the young Prince Bladud contracted leprosy and was banished from his father’s royal court (Bowman 1998). He was set to work as a swine herdsman, but soon his pigs also caught the disease. But one day, when the pigs had been wallowing in a warm mud spring by the river, one by one they emerged from the mud with clear signs of healing. On seeing this, Bladud did likewise and he too emerged cleansed with greatly improved health. The Prince was able to return to his royal duties, later becoming the mythical God-King, father to King Lear, but, more importantly, making the link between groundwater and medicine. Many years later, Robert the Bruce would enjoy the same cure, this time at a spring emerging from Devonian sandstone at Scotlandwell in Fife (Robins et more...

Published
2013

29. APPARATUS Problems with capnography at high altitude.

Author

Pattinson, K., Myers, S., and Gardner-Thorpe, C.

Subjects
CAPNOGRAPHY, RESPIRATORY gas monitoring, PULMONARY function tests, MEDICAL equipment
Abstract

The aim of this study was to investigate why capnographs malfunction at high altitude, in order to suggest ways of improving instrument reliability. Four machines were decompressed to simulated high altitude and measurements taken. The study showed that the reduced air density at altitude has effects upon the pump, causing difficulty in entraining gas, and that high altitude has additional effects upon calibration of the instruments. [ABSTRACT FROM AUTHOR] more...

Published
2004
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30. Anterior interosseous nerve palsy: spontaneous recovery in two patients.

Author

Gardner-Thorpe, Christopher and Gardner-Thorpe, C

Abstract

The case histories of two patients who developed an anterior interosseous nerve palsy apparently as a result of an external pressure injury are reported. Both patients recovered fully without surgical exploration, one 19 months and the other nine months after the onset. It is stressed that complete recovery may occur spontaneously. [ABSTRACT FROM AUTHOR] more...

Published
1974

31. Jakob-Creutzfeldt disease. Modification of clinical and electroencephalographic activity with methylphenidate and diazepam.

Author

Elliott, F., Gardner-Thorpe, C., Barwick, D. D., and Foster, J. B.

Subjects
CREUTZFELDT-Jakob disease diagnosis, DIAZEPAM, METHYLPHENIDATE, CEREBRAL cortex, CREUTZFELDT-Jakob disease, ELECTROENCEPHALOGRAPHY, THERAPEUTICS
Abstract

The electroencephalogram in three patients with Jakob-Creutzfeldt disease showed two separate abnormalities—namely, progressive background suppression and periodic generalized synchronous triphasic sharp wave complexes which evolve to a uniform morphology and periodicity. The abnormalities, when found in the EEG of a patient in middle-age with a dementing illness, should not be confused with other periodic electroencephalographic phenomena. Since the neuropathological abnormalities of Jakob-Creutzfeldt disease are non-specific, the electroencephalogram is essential for the recognition of this disorder, although serial recordings may be necessary to establish the diagnosis. Modification of the electroencephalographic abnormalities occurs with afferent stimuli and with methylphenidate or diazepam, suggesting that the phenomenon of background suppression is independent of the presence of the periodic complexes. Modification of clinical activity with methylphenidate suggests that some degree of reversibility of function exists in this inexorably fatal disorder. Further detailed studies of the electroencephalogram in cases of Jakob-Creutzfeldt disease are indicated. [ABSTRACT FROM PUBLISHER] more...

Published
1974

34. Peripheral neuropathy after disulfiram administration.

Author

Gardner-Thorpe, Christopher, Benjamin, Sidney, Gardner-Thorpe, C, and Benjamin, S

Abstract

Peripheral neuropathy and optic neuritis occurring in alcoholics are sometimes due to the toxic effects of disulfiram rather than to alcohol. Unless this is considered in the management of such patients it is likely that administration of the drug will be continued. In the past there have been reports of 16 cases of peripheral neuropathy and six cases of optic neuritis, possibly caused in this way; these reports are reviewed and a further six cases are described. The effects of disulfiram on the nervous system are briefly discussed. [ABSTRACT FROM AUTHOR] more...

Published
1971

35. A brainstem syndrome associated with Mycoplasma pneumoniae infection. A report of two cases.

Author

Jachuck, S. J., Gardner-Thorpe, C., Clark, F., and Foster, J. B.

Abstract

Two patients with a serologically-proved infection with (MP) developed cranial nerve pareses which cleared spontaneously within 1 month of the onset. The sixth and seventh cranial nerves were the most severely affected. It is suggested that the signs were due to a mild brainstem encephalitis associated with the MP infection. The benign course of the syndrome is emphasized. The neurological complications of MP infection may be commoner than has been generally supposed. [ABSTRACT FROM PUBLISHER] more...

Published
1975

36. EPILEPSY AND INSANITY

Author

Fenwick, P., primary, Fenton, G., additional, Aspinall, A., additional, Gardner-Thorpe, C., additional, Bowden, P., additional, Godwin-Austen, R., additional, Cairnie, V., additional, Howard, C., additional, Donovan, W., additional, Mackeith, J., additional, D'Orban, P., additional, Minto, A., additional, Parsonage, M., additional, Oxley, J., additional, Pitcher, D., additional, Rollin, H., additional, Salmon, M., additional, Taylor, D., additional, Taylor, J., additional, Tennent, G., additional, and White, S., additional more...

Published
1984
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