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132 results on '"Garello, Francesca"'

3. MRI detection of free‐contrast agent nanoparticles.

Author

Garello, Francesca, Cavallari, Eleonora, Capozza, Martina, Ribodino, Marta, Parolisi, Roberta, Buffo, Annalisa, and Terreno, Enzo

Subjects
NANOPARTICLES, MEDICAL research, LIPOSOMES, LYMPH nodes, MAGNETIC resonance imaging
Abstract

Purpose: The integration of nanotechnology into biomedical imaging has significantly advanced diagnostic and theranostic capabilities. However, nanoparticle detection in imaging relies on functionalization with appropriate probes. In this work, a new approach to visualize free‐label nanoparticles using MRI and MRS techniques is described, consisting of detecting by 1H CSI specific proton signals belonging to the components naturally present in most of the nanosystems used in preclinical and clinical research. Methods: Three different nanosystems, namely lipid‐based micelles, liposomes, and perfluorocarbon‐based nanoemulsions, were synthesized, characterized by high resolution NMR and then visualized by 1H CSI at 300 MHz. Subsequently the best 1H CSI performing system was administered to murine models of cancer to evaluate the possibility of tracking the nanosystem by looking at its proton associated signal. Furthermore, an in vitro comparison between 1H CSI and 19F MRI was carried out. Results: The study successfully demonstrates the feasibility of detecting nanoparticles using MRI/MRS without probe functionalization, employing 1H CSI. Among the nanosystems tested, the perfluorocarbon‐based nanoemulsion exhibited the highest SNR. Consequently, it was evaluated in vivo, where its detection was achievable within tumors and inflamed regions via 1H CSI, and in lymph nodes via PRESS. Conclusions: These findings present a promising avenue for nanoparticle imaging in biomedical applications, offering potential enhancements to diagnostic and theranostic procedures. This non‐invasive approach has the capacity to advance imaging techniques and expand the scope of nanoparticle‐based biomedical research. Further exploration is necessary to fully explore the implications and applications of this method. [ABSTRACT FROM AUTHOR]

Published
2025
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7. Therapeutic targeting of Lyn kinase to treat chorea-acanthocytosis

Author

Peikert, Kevin, Federti, Enrica, Matte, Alessandro, Constantin, Gabriela, Pietronigro, Enrica Caterina, Fabene, Paolo Francesco, Defilippi, Paola, Turco, Emilia, Del Gallo, Federico, Pucci, Pietro, Amoresano, Angela, Illiano, Anna, Cozzolino, Flora, Monti, Maria, Garello, Francesca, Terreno, Enzo, Alper, Seth Leo, Glaß, Hannes, Pelzl, Lisann, Akgün, Katja, Ziemssen, Tjalf, Ordemann, Rainer, Lang, Florian, Brunati, Anna Maria, Tibaldi, Elena, Andolfo, Immacolata, Iolascon, Achille, Bertini, Giuseppe, Buffelli, Mario, Zancanaro, Carlo, Lorenzetto, Erika, Siciliano, Angela, Bonifacio, Massimiliano, Danek, Adrian, Walker, Ruth Helen, Hermann, Andreas, and De Franceschi, Lucia

Published
2021
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15. Data from Inactivation of Citron Kinase Inhibits Medulloblastoma Progression by Inducing Apoptosis and Cell Senescence

Author

Pallavicini, Gianmarco, primary, Sgrò, Francesco, primary, Garello, Francesca, primary, Falcone, Mattia, primary, Bitonto, Valeria, primary, Berto, Gaia E., primary, Bianchi, Federico T., primary, Gai, Marta, primary, Chiotto, Alessandra M.A., primary, Filippi, Miriam, primary, Cutrin, Juan C., primary, Ala, Ugo, primary, Terreno, Enzo, primary, Turco, Emilia, primary, and Cunto, Ferdinando Di, primary

Published
2023
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16. Supplementary figures and legends from Inactivation of Citron Kinase Inhibits Medulloblastoma Progression by Inducing Apoptosis and Cell Senescence

Author

Pallavicini, Gianmarco, primary, Sgrò, Francesco, primary, Garello, Francesca, primary, Falcone, Mattia, primary, Bitonto, Valeria, primary, Berto, Gaia E., primary, Bianchi, Federico T., primary, Gai, Marta, primary, Chiotto, Alessandra M.A., primary, Filippi, Miriam, primary, Cutrin, Juan C., primary, Ala, Ugo, primary, Terreno, Enzo, primary, Turco, Emilia, primary, and Cunto, Ferdinando Di, primary

Published
2023
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17. In Humanized Sickle Cell Mice, Imatinib Protects Against Sickle Cell–Related Injury

Author

Federti, Enrica, primary, Matte, Alessandro, additional, Recchiuti, Antonio, additional, Garello, Francesca, additional, Ghigo, Alessandra, additional, El Nemer, Wassim, additional, Terreno, Enzo, additional, Amoresano, Angela, additional, Mattoscio, Domenico, additional, Turrini, Franco, additional, Lebouef, Christophe, additional, Janin, Anne, additional, Pantaleo, Antonella, additional, Russo, Roberta, additional, Marin, Mickael, additional, Iatcencko, Iana, additional, Riccardi, Veronica, additional, Siciliano, Angela, additional, Iolascon, Achille, additional, Brugnara, Carlo, additional, and De Franceschi, Lucia, additional

Published
2023
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23. Biodegradable polyelectrolyte/magnetite capsules for MR imaging and magnetic targeting of tumors

Author

Yulia, Svenskaya, Garello, Francesca, Ekaterina, Lengert, Anastasiia, Kozlova, Roman, Verkhovskii, Bitonto, Valeria, Ruggiero, MARIA ROSARIA, Sergey, German, Dmitry, Gorin, and Terreno, Enzo

Subjects
magnetite nanoparticles, magnetic resonance imaging, magnetically-guided drug delivery systems, magnetically-guided drug delivery systems, polyelectrolyte submicron capsules, magnetite nanoparticles, magnetic resonance imaging, targeted drug delivery, polyelectrolyte submicron capsules, targeted drug delivery
Published
2021

25. Magnetic materials and systems: Domain structure visualization and other characterization techniques for the application in the materials science and biomedicine

Author

Nisticò, R, Cesano, F, Garello, F, Nisticò, Roberto, Cesano, Federico, Garello, Francesca., Nisticò, R, Cesano, F, Garello, F, Nisticò, Roberto, Cesano, Federico, and Garello, Francesca.

Abstract

Magnetic structures have attracted a great interest due to their multiple applications, from physics to biomedicine. Several techniques are currently employed to investigate magnetic characteristics and other physicochemical properties of magnetic structures. The major objective of this review is to summarize the current knowledge on the usage, advances, advantages, and disadvantages of a large number of techniques that are currently available to characterize magnetic systems. The present review, aiming at helping in the choice of the most suitable method as appropriate, is divided into three sections dedicated to characterization techniques. Firstly, the magnetism and magnetization (hysteresis) techniques are introduced. Secondly, the visualization methods of the domain structures by means of different probes are illustrated. Lastly, the characterization of magnetic nanosystems in view of possible biomedical applications is discussed, including the exploitation of magnetism in imaging for cell tracking/visualization of pathological alterations in living systems (mainly by magnetic resonance imaging, MRI).

Published
2020

26. Targeting Chronic Myeloid Leukemia Stem/Progenitor Cells Using Venetoclax-Loaded Immunoliposome

Author

Houshmand, Mohammad, primary, Garello, Francesca, additional, Stefania, Rachele, additional, Gaidano, Valentina, additional, Cignetti, Alessandro, additional, Spinelli, Michela, additional, Fava, Carmen, additional, Nikougoftar Zarif, Mahin, additional, Galimberti, Sara, additional, Pungolino, Ester, additional, Annunziata, Mario, additional, Luciano, Luigia, additional, Specchia, Giorgina, additional, Bocchia, Monica, additional, Binotto, Gianni, additional, Bonifacio, Massimiliano, additional, Martino, Bruno, additional, Pregno, Patrizia, additional, Stagno, Fabio, additional, Iurlo, Alessandra, additional, Russo, Sabina, additional, Aime, Silvio, additional, Circosta, Paola, additional, and Saglio, Giuseppe, additional

Published
2021
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35. Novel Gastrin-Releasing Peptide Receptor Targeted Near-Infrared Fluorescence Dye for Image-Guided Surgery of Prostate Cancer

Author

Pagoto, Amerigo, primary, Garello, Francesca, additional, Marini, Giada Maria, additional, Tripepi, Martina, additional, Arena, Francesca, additional, Bardini, Paola, additional, Stefania, Rachele, additional, Lanzardo, Stefania, additional, Valbusa, Giovanni, additional, Porpiglia, Francesco, additional, Manfredi, Matteo, additional, Aime, Silvio, additional, and Terreno, Enzo, additional

Published
2019
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40. Inactivation of Citron Kinase Inhibits Medulloblastoma Progression by Inducing Apoptosis and Cell Senescence

Author

Pallavicini, Gianmarco, primary, Sgrò, Francesco, additional, Garello, Francesca, additional, Falcone, Mattia, additional, Bitonto, Valeria, additional, Berto, Gaia E., additional, Bianchi, Federico T., additional, Gai, Marta, additional, Chiotto, Alessandra M.A., additional, Filippi, Miriam, additional, Cutrin, Juan C., additional, Ala, Ugo, additional, Terreno, Enzo, additional, Turco, Emilia, additional, and Cunto, Ferdinando Di, additional

Published
2018
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43. An efficient MRI agent targeting extracellular markers in prostate adenocarcinoma.

Author

Pagoto, Amerigo, Tripepi, Martina, Stefania, Rachele, Lanzardo, Stefania, Livio Longo, Dario, Garello, Francesca, Porpiglia, Francesco, Manfredi, Matteo, Aime, Silvio, and Terreno, Enzo

Abstract

Purpose: Prostate cancer (PCa) is the most widespread tumor affecting males in Western countries. We propose a novel MRI molecular tetrameric probe based on the heptadentate gadolinium (Gd)‐AAZTA (6‐amino‐6‐methylperhydro‐1,4‐diazepinetetraacetic acid) that is able to in vivo detect PCa through the recognition of the fibrin–fibronectin (FB–FN) complex. Methods: The peptide CREKA (Cys‐Arg‐Glu‐Lys‐Ala), targeting the FB–FN complex in the reactive stroma of the tumor, was synthesized by solid phase peptide synthesis (SPPS) and conjugated to the tetramer dL‐(Gd‐AAZTA)4. The resulting probe was characterized by 1H relaxometry, tested in vitro on FB clots and in vivo on an orthotopic mouse model of PCa. Results: CREKA‐dL‐(Gd‐AAZTA)4 showed a remarkable relaxivity of 18.2 mMGd-1s−1 (0.47 T, 25°C) because of the presence of 2 water molecules (q = 2) in the inner coordination sphere of each Gd3+ ion, whose rotational motion (τR) is lengthened as the result of the relatively high molecular weight. The probe displayed a detectable affinity for plasma‐derived FB clots. On intravenous injection of the probe in an orthotopic mouse model of PCa, a significant increase in the prostate T1 contrast (~40%) was observed. The MRI signal appears statistically higher either with respect to the one observed for the control probes and to the one detected when CREKA‐dL‐(Gd‐AAZTA)4 was administered to healthy animals. Conclusions: This study demonstrated the ability of the CREKA‐dL‐(Gd‐AAZTA)4 probe to specifically localize in prostate tumor after injection. The high relaxivity of the probe allows the reduction of the injected dose to 20 µmolGd/kg, yielding a good in vivo contrast enhancement in the region of prostate tumor. [ABSTRACT FROM AUTHOR]

Published
2019
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48. Additional file 1 of Therapeutic targeting of Lyn kinase to treat chorea-acanthocytosis

Author

Peikert, Kevin, Federti, Enrica, Matte, Alessandro, Constantin, Gabriela, Pietronigro, Enrica Caterina, Fabene, Paolo Francesco, Defilippi, Paola, Turco, Emilia, Gallo, Federico Del, Pucci, Pietro, Amoresano, Angela, Illiano, Anna, Cozzolino, Flora, Monti, Maria, Garello, Francesca, Terreno, Enzo, Alper, Seth Leo, Glaß, Hannes, Pelzl, Lisann, Akgün, Katja, Tjalf Ziemssen, Ordemann, Rainer, Lang, Florian, Brunati, Anna Maria, Tibaldi, Elena, Andolfo, Immacolata, Iolascon, Achille, Bertini, Giuseppe, Buffelli, Mario, Zancanaro, Carlo, Lorenzetto, Erika, Siciliano, Angela, Bonifacio, Massimiliano, Danek, Adrian, Walker, Ruth Helen, Hermann, Andreas, and De Franceschi, Lucia

Subjects
Data_FILES, 3. Good health
Abstract

Additional file 1.

49. Additional file 1 of Therapeutic targeting of Lyn kinase to treat chorea-acanthocytosis

Author

Peikert, Kevin, Federti, Enrica, Matte, Alessandro, Constantin, Gabriela, Pietronigro, Enrica Caterina, Fabene, Paolo Francesco, Defilippi, Paola, Turco, Emilia, Gallo, Federico Del, Pucci, Pietro, Amoresano, Angela, Illiano, Anna, Cozzolino, Flora, Monti, Maria, Garello, Francesca, Terreno, Enzo, Alper, Seth Leo, Glaß, Hannes, Pelzl, Lisann, Akgün, Katja, Tjalf Ziemssen, Ordemann, Rainer, Lang, Florian, Brunati, Anna Maria, Tibaldi, Elena, Andolfo, Immacolata, Iolascon, Achille, Bertini, Giuseppe, Buffelli, Mario, Zancanaro, Carlo, Lorenzetto, Erika, Siciliano, Angela, Bonifacio, Massimiliano, Danek, Adrian, Walker, Ruth Helen, Hermann, Andreas, and De Franceschi, Lucia

Subjects
Data_FILES, 3. Good health
Abstract

Additional file 1.

50. Amphoteric β-cyclodextrin coated iron oxide magnetic nanoparticles: new insights into synthesis and application in MRI.

Author

Calsolaro F, Garello F, Cavallari E, Magnacca G, Trukhan MV, Valsania MC, Cravotto G, Terreno E, and Martina K

Abstract

This work presents a group of high-quality hydrophilic and negatively charged coated, iron oxide magnetic nanoparticles (MNPs) that have been prepared using a microwave-ultrasound-assisted protocol, and demonstrates the great impact that the synthetic strategy has on the resulting MNPs. The different coatings tested, including citric acid, carboxymethyl dextran and β-cyclodextrin (βCD)/citric acid have been compared and have shown good dispersibility and stability. The ability of βCD to maintain the inclusive properties of the coated MNPs has been proven as well as their cytocompatibility. An amino citrate-modified βCD is proposed and its capabilities as a flexible amphoteric adsorbing device have been studied. The NMR relaxometric properties of the coated MNPs have been investigated using field-cycling nuclear magnetic relaxation dispersion profiles. For the amino citrate-modified βCD system, the order of magnitude of the Néel relaxation time is in the typical range for superparamagnetic systems' reversal times, i.e. , 10 -10 -10 -7 s. The r d value corresponds to the physical radius of the magnetic core, suggesting that, in this particular case, the coating does not prevent the diffusive motion of water molecules, which provide the basis for potential future magnetic resonance imaging (MRI) applications., Competing Interests: The authors declare no competing financial interest., (This journal is © The Royal Society of Chemistry.)

Published
2024
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