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This tutorial review summarizes the basic new concepts of green chemistry in relation to education and pharmaceutical industries. The origin and history of Green analytical chemistry is described in detail. Basic twelve principles are well summarized with suitable examples of each principle such as oxidation of alcohol, enzymatic reactions, and non-covalent derivatization. This article also covers the concept of E-factor for waste minimization, detailed various solvent selection guidelines and tools for betterment of synthetic pathways at laboratory and industrial level. The efficiency of green chemistry in organic synthesis for greenness of traditional organic synthesis methods are discussed. Nowadays, there is a constant need to add catalysts for chemical synthesis to minimize or downsize the risks correspondent with chemical manufacture. Catalyst helps to enhance air quality by reducing harmful gas emissions such as NOx. It cuts down on the use of VOCs (volatile organic compounds). It developed an alternative catalytic method which substitutes the usage of chlorine-based intermediates in chemical synthesis and processes. Biocatalysts is a term used to describe compounds that aid in the stimulation of biological reactions. In the fine chemical industry, cleaner biocatalytic alternatives are replacing traditional chemical operations.

Plants have filled in as a significant wellspring of elements for conventional drugs for centuries. Verifiable records and present day ethno botanical field examines feature their significance in the conventional treatment of irresistible malady. Be that as it may, plants form just a minor level of present collection of FDA-endorsed antimicrobial medications. The present article gives an outline of active components of plants as hint for other wellspring of antimicrobial agents to be used in the battle against microscopic organisms. It additionally surveys the ethno botanical way to deal with sedate disclosure and talks about various inventive focuses for future medication revelation endeavours in this field. Without an uncertainty, antimicrobials are miracle tranquilizers. They have represented a very long time against different irresistible infections and spared a huge number of lives. The ongoing disappointment of antimicrobials because of the sensational rise of multidrug-safe microbes and fast spread of new diseases, be that as it may, prompts wellbeing associations and the pharmaceutical business worldwide to change their methodology and to expand improvement of antimicrobials against quickly rising anti-infection safe microorganisms. In spite of the fact that there is thinking about elective wellsprings of characteristic antimicrobial molecules from plants having different methods of activity, some of which have been utilized in regular medication for a considerable length of time and have appeared to have serious impacts contrasted with other antimicrobials. This examination portrays plant intensity as an elective hotspot for antimicrobial agents.

Tecoma stans (Fam. Bignoniaceae) is also popularly known as yellow bells and yellow trumpet bush in vernacular terminology. Limited and variable data are available from the literature regarding the quantification of luteolin, apigenin and chrysoeriol, which are considered as the most active pharmacological active constituents. High-performance liquid chromatography–photodiode array detection has been developed for the determination of the bioactive flavonoids, luteolin, apigenin and chrysoeriol, from the methanolic extract of the leaves of T. stans. A column packed with a pentafluorophenyl-based stationary phase was used for the separation of the analytes under gradient elution. The detection wavelength was 345 nm. The validation of the method as per the International Council on Harmonisation (ICH) guidelines (ICH 2005) for linearity, accuracy and precision was investigated and found within limits specified by the ICH guidelines. The method was linear over with a good regression coefficient of more than 0.99. The limit of detection of the method was 0.68, 2.97 and 1.76 μg/mL for luteolin, apigenin and chrysoeriol, respectively. In conclusion, a reliable and reproducible method was devised that can be used for the estimation of the said components from T. stans. [ABSTRACT FROM AUTHOR]

Astaxanthin is a xanthophyll carotenoid, well known for its potent anti-inflammatory and antioxidant properties, owing to its unsaturated molecular structure. Aquatic plants and animals contain the hydrophobic carotenoid astaxanthin, which is thought to possess a number of advantageous biological traits. However, due to its weak bioavailability and low water solubility, its use as a nutraceutical in food is currently restricted. Cubosomal encapsulation has been considered an effective alternative for improving the bioavailability and solubility of hydrophobic bioactives. The current paper aimed to conquer these issues by encapsulating astaxanthin in lyotropic liquid crystal nano-formulations prepared via the fabrication method. The physicochemical properties of astaxanthin-loaded cubosomes (AST-LC) have also been analyzed, in order to know the morphology of the prepared formulations and their bioavailability in the biological system. The formulation has been tested for particle size, thermal behavior, zeta potential, crystallinity, encapsulation efficiency, and drug-polymer interactions. The observed experimental results showed the particle size and zeta potential of astaxanthin-loaded cubosomes (AST-LC) as 199 ± 0.23 nm −27.4 ± 4.67 mV, with a small polydispersity index (0.283 ± 1.01). The cubic structure and nano-range size of the ideal formulation were verified by a field emission scanning electron microscope (FESEM) and (HRTEM) high-resolution transmission electron microscopic examination. The formulation exhibits a higher encapsulation efficiency with good yield. Results from X-ray diffraction and diffraction scanning calorimetry demonstrated an amorphous state of astaxanthin incorporated into the formulation. Fourier transform infrared spectroscopy (FTIR) analysis of AST-LC showed the absence of astaxanthin main peaks, indicating its complete encapsulation inside the formulation. The drug–excipient interaction was carried out with diffraction scanning calorimetry DSC and FTIR, resulting in no interaction between them. These results offered important details about increasing astaxanthin bioavailability by incorporating it into cubosomes. Furthermore, the astaxanthin loaded into cubosomes has been evaluated for antioxidant potency, compared with astaxanthin extract using 2,2-diphenylpicrylhydrazylassay (DPPH assay). [ABSTRACT FROM AUTHOR]

Depression is a mental state characterized by feelings of sadness, loneliness, despair, low self-esteem, and selfreproach. Pharmacological therapy is considered evidenced based approach and frequently used for the treatments of depression. Pharmacological healing of depression involves the use of different class of drugs like monoamine oxidase inhibitors [MAOI], tricyclic antidepressant drugs [TCAD] and 2nd generation antidepressant drugs [2GAD] including the selective nor epinephrine and serotonin reuptake-inhibitors. However, problems associated with pharmacological therapy are patient adherence, high treatment cost, drug associated side effects, low diminution rates and high placebo responses. Objective of the present review is the compilation of CAM (complementary and alternative medicine) approaches for the treatment of depression. CAM approaches includes the use of herbal remedy, traditional Chinese medicinal plant formulation, traditional Japanese herbal medicine, Ayurvedic formulations, nutraceuticals, aromatherapy, acupuncture, music therapy, stress and relaxation techniques, yoga and meditation. Benefits of the CAM approaches embrace the relatively reduced prevalence of adverse effects, economical, better patient compliance and are holistic approach to the folk’s problems. The database was searched using the different term “Depression: Alternative Therapies”, “Complementary and alternative medicine for the treatment of depressive disorder” and depressive disorder in combination with St John’s wort, exercise, acupuncture, and omega-3 fatty acids. The specific CAM approaches were selected based on the available reviews and clinical studies. [ABSTRACT FROM AUTHOR]