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28. Patient Safety and Quality Care for Children with Intellectual Disability: An Action Research Study

Author

Ong, Natalie, Gee, Brendan Loo, Long, Janet C., Zieba, Jerzy, Tomsic, Gail, Garg, Pankaj, Lapointe, Caleb, Silove, Natalie, and Eapen, Valsamma

Abstract

Children with intellectual disability experience significant challenges in accessing and receiving high-quality healthcare leading to poorer health outcomes and negative patient experiences. Families of these children often report a need for healthcare staff to better understand, communicate, and collaborate for better care while staff acknowledge a lack of training. To address this, we utilised an action research framework with a pre- and post-survey to evaluate an integrated continuing professional development and quality improvement program combining strategies from education, behavioural psychology and quality improvement that was delivered in two departments within a tertiary children's Hospital in Metropolitan Sydney in 2019-2020. Parents reported noticeable changes in the clinical practice of staff, and staff acknowledged and attributed their shift in behaviour to raising awareness and discussions around necessary adaptations. The program demonstrates a novel method for knowledge translation to practice and systems improvements.

Published
2023
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30. 4D Flow cardiovascular magnetic resonance consensus statement: 2023 update

Author

Bissell, Malenka M., Raimondi, Francesca, Ait Ali, Lamia, Allen, Bradley D., Barker, Alex J., Bolger, Ann, Burris, Nicholas, Carhäll, Carl-Johan, Collins, Jeremy D., Ebbers, Tino, Francois, Christopher J., Frydrychowicz, Alex, Garg, Pankaj, Geiger, Julia, Ha, Hojin, Hennemuth, Anja, Hope, Michael D., Hsiao, Albert, Johnson, Kevin, Kozerke, Sebastian, Ma, Liliana E., Markl, Michael, Martins, Duarte, Messina, Marci, Oechtering, Thekla H., van Ooij, Pim, Rigsby, Cynthia, Rodriguez-Palomares, Jose, Roest, Arno A. W., Roldán-Alzate, Alejandro, Schnell, Susanne, Sotelo, Julio, Stuber, Matthias, Syed, Ali B., Töger, Johannes, van der Geest, Rob, Westenberg, Jos, Zhong, Liang, Zhong, Yumin, Wieben, Oliver, and Dyverfeldt, Petter

Published
2023
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31. Automated 4D flow cardiac MRI pipeline to derive peak mitral inflow diastolic velocities using short-axis cine stack: two centre validation study against echocardiographic pulse-wave doppler

Author

Assadi, Hosamadin, Li, Rui, Grafton-Clarke, Ciaran, Uthayachandran, Bhalraam, Alabed, Samer, Maiter, Ahmed, Archer, Gareth, Swoboda, Peter P., Sawh, Chris, Ryding, Alisdair, Nelthorpe, Faye, Kasmai, Bahman, Ricci, Fabrizio, van der Geest, Rob J., Flather, Marcus, Vassiliou, Vassilios S., Swift, Andrew J., and Garg, Pankaj

Published
2023
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38. Topological Approaches for Vector Variational Inequality Problems

Author

Gupta, Ankit, Kumar, Satish, Garg, Pankaj Kumar, Gowda, G. D. Veerappa, Editor-in-Chief, Kesavan, S., Editor-in-Chief, Nekka, Fahima, Editor-in-Chief, Khan, Akhtar A., Editorial Board Member, Rangarajan, Govindan, Editorial Board Member, Balachandran, K., Editorial Board Member, Sreenivasan, K. R., Editorial Board Member, Brokate, Martin, Editorial Board Member, Nashed, M. Zuhair, Editorial Board Member, Gupta, N. K., Editorial Board Member, Zahra, Noore, Editorial Board Member, Manchanda, Pammy, Editorial Board Member, Lozi, René Pierre, Editorial Board Member, Aslan, Zafer, Editorial Board Member, and Acharjee, Santanu, editor

Published
2023
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48. Functional GLP-1R antibodies identified from a synthetic GPCR-focused library demonstrate potent blood glucose control.

Author

Liu, Qiang, Garg, Pankaj, Hasdemir, Burcu, Wang, Linya, Tuscano, Emily, Sever, Emily, Keane, Erica, Hernandez, Ana, Yuan, Tom, Kwan, Eric, Lai, Joyce, Szot, Gregory, Paruthiyil, Sreenivasan, Axelrod, Fumiko, and K Sato, Aaron

Subjects
GPCR, agonist, antagonist, glp-1 peptide, glucose level, panning, phage display library, Animals, Antibodies, Monoclonal, Binding Sites, Antibody, Biomarkers, Blood Glucose, CHO Cells, Cell Surface Display Techniques, Cricetulus, Glucagon-Like Peptide-1 Receptor, Glycemic Control, High-Throughput Screening Assays, Hypoglycemic Agents, Incretins, Ligands, Male, Mice, Inbred C57BL, Peptide Library, Protein Interaction Domains and Motifs, Rats, Sprague-Dawley, Mice, Rats
Abstract

G protein-coupled receptors (GPCRs) are a group of seven-transmembrane receptor proteins that have proven to be successful drug targets. Antibodies are becoming an increasingly promising modality to target these receptors due to their unique properties, such as exquisite specificity, long half-life, and fewer side effects, and their improved pharmacokinetic and pharmacodynamic profiles compared to peptides and small molecules, which results from their more favorable biodistribution. To date, there are only two US Food and Drug Administration-approved GPCR antibody drugs, namely erenumab and mogamulizumab, and this highlights the challenges encountered in identifying functional antibodies against GPCRs. Utilizing Twists precision DNA writing technologies, we have created a GPCR-focused phage display library with 1 × 1010 diversity. Specifically, we mined endogenous GPCR binding ligand and peptide sequences and incorporated these binding motifs into the heavy chain complementarity-determining region 3 in a synthetic antibody library. Glucagon-like peptide-1 receptor (GLP-1 R) is a class B GPCR that acts as the receptor for the incretin GLP-1, which is released to regulate insulin levels in response to food intake. GLP-1 R agonists have been widely used to increase insulin secretion to lower blood glucose levels for the treatment of type 1 and type 2 diabetes, whereas GLP-1 R antagonists have applications in the treatment of severe hypoglycemia associated with bariatric surgery and hyperinsulinomic hypoglycemia. Here we present the discovery and creation of both antagonistic and agonistic GLP-1 R antibodies by panning this GPCR-focused phage display library on a GLP-1 R-overexpressing Chinese hamster ovary cell line and demonstrate their in vitro and in vivo functional activity.

Published
2021

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