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32 results on '"Garg, Sriram G"'

3. Molecular model of a bacterial flagellar motorin situreveals a “parts-list” of protein adaptations to increase torque

Author

Drobnič, Tina, primary, Cohen, Eli J., additional, Alzheimer, Mona, additional, Froschauer, Kathrin, additional, Svensson, Sarah, additional, Singh, Nanki, additional, Garg, Sriram G., additional, Henderson, Louie, additional, Umrekar, Trishant, additional, Nans, Andrea, additional, Ribardo, Deborah, additional, Hochberg, Georg, additional, Hendrixson, David R., additional, Sharma, Cynthia M., additional, Rosenthal, Peter, additional, and Beeby, Morgan, additional

Published
2023
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13. Gene Duplications Trace Mitochondria to the Onset of Eukaryote Complexity

Author

Tria, Fernando D K, primary, Brueckner, Julia, additional, Skejo, Josip, additional, Xavier, Joana C, additional, Kapust, Nils, additional, Knopp, Michael, additional, Wimmer, Jessica L E, additional, Nagies, Falk S P, additional, Zimorski, Verena, additional, Gould, Sven B, additional, Garg, Sriram G, additional, and Martin, William F, additional

Published
2021
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15. The future of origin of life research: Bridging decades-old divisions

Author

Petrology, Preiner, Martina, Asche, Silke, Becker, Sidney, Betts, Holly C., Boniface, Adrien, Camprubi, Eloi, Chandru, Kuhan, Erastova, Valentina, Garg, Sriram G., Khawaja, Nozair, Kostyrka, Gladys, Machné, Rainer, Moggioli, Giacomo, Muchowska, Kamila B., Neukirchen, Sinje, Peter, Benedikt, Pichlhöfer, Edith, Radványi, Ádám, Rossetto, Daniele, Salditt, Annalena, Schmelling, Nicolas M., Sousa, Filipa L., Tria, Fernando D.K., Vörös, Dániel, Xavier, Joana C., Petrology, Preiner, Martina, Asche, Silke, Becker, Sidney, Betts, Holly C., Boniface, Adrien, Camprubi, Eloi, Chandru, Kuhan, Erastova, Valentina, Garg, Sriram G., Khawaja, Nozair, Kostyrka, Gladys, Machné, Rainer, Moggioli, Giacomo, Muchowska, Kamila B., Neukirchen, Sinje, Peter, Benedikt, Pichlhöfer, Edith, Radványi, Ádám, Rossetto, Daniele, Salditt, Annalena, Schmelling, Nicolas M., Sousa, Filipa L., Tria, Fernando D.K., Vörös, Dániel, and Xavier, Joana C.

Published
2020

16. The Future of Origin of Life Research: Bridging Decades-Old Divisions

Author

Preiner, Martina, Asche, Silke, Becker, Sidney, Betts, Holly C., Boniface, Adrien, Camprubi, Eloi, Chandru, Kuhan, Erastova, Valentina, Garg, Sriram G., Khawaja, Nozair, Kostyrka, Gladys, Machne, Rainer, Moggioli, Giacomo, Muchowska, Kamila B., Neukirchen, Sinje, Peter, Benedikt, Pichlhoefer, Edith, Radvanyi, Adam, Rossetto, Daniele, Salditt, Annalena, Schmelling, Nicolas M., Sousa, Filipa L., Tria, Fernando D. K., Voros, Daniel, Xavier, Joana C., Preiner, Martina, Asche, Silke, Becker, Sidney, Betts, Holly C., Boniface, Adrien, Camprubi, Eloi, Chandru, Kuhan, Erastova, Valentina, Garg, Sriram G., Khawaja, Nozair, Kostyrka, Gladys, Machne, Rainer, Moggioli, Giacomo, Muchowska, Kamila B., Neukirchen, Sinje, Peter, Benedikt, Pichlhoefer, Edith, Radvanyi, Adam, Rossetto, Daniele, Salditt, Annalena, Schmelling, Nicolas M., Sousa, Filipa L., Tria, Fernando D. K., Voros, Daniel, and Xavier, Joana C.

Abstract

Research on the origin of life is highly heterogeneous. After a peculiar historical development, it still includes strongly opposed views which potentially hinder progress. In the 1st Interdisciplinary Origin of Life Meeting, early-career researchers gathered to explore the commonalities between theories and approaches, critical divergence points, and expectations for the future. We find that even though classical approaches and theories-e.g., bottom-up and top-down, RNA world vs. metabolism-first-have been prevalent in origin of life research, they are ceasing to be mutually exclusive and they can and should feed integrating approaches. Here we focus on pressing questions and recent developments that bridge the classical disciplines and approaches, and highlight expectations for future endeavours in origin of life research.

Published
2020

18. The Future of Origin of Life Research: Bridging Decades-Old Divisions

Author

Preiner, Martina, primary, Asche, Silke, additional, Becker, Sidney, additional, Betts, Holly C., additional, Boniface, Adrien, additional, Camprubi, Eloi, additional, Chandru, Kuhan, additional, Erastova, Valentina, additional, Garg, Sriram G., additional, Khawaja, Nozair, additional, Kostyrka, Gladys, additional, Machné, Rainer, additional, Moggioli, Giacomo, additional, Muchowska, Kamila B., additional, Neukirchen, Sinje, additional, Peter, Benedikt, additional, Pichlhöfer, Edith, additional, Radványi, Ádám, additional, Rossetto, Daniele, additional, Salditt, Annalena, additional, Schmelling, Nicolas M., additional, Sousa, Filipa L., additional, Tria, Fernando D. K., additional, Vörös, Dániel, additional, and Xavier, Joana C., additional

Published
2020
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23. Anomalous Phylogenetic Behavior of Ribosomal Proteins in Metagenome-Assembled Asgard Archaea.

Author

Garg, Sriram G, Kapust, Nils, Lin, Weili, Knopp, Michael, Tria, Fernando D K, Nelson-Sathi, Shijulal, Gould, Sven B, Fan, Lu, Zhu, Ruixin, Zhang, Chuanlun, and Martin, William F

Subjects
*ARCHAEBACTERIA, *GENES, *MICROBIAL diversity, *EUKARYOTIC cells, *RIBOSOMAL proteins, *NUCLEOTIDE sequencing, *RIBOSOMAL DNA, *CHIMERIC proteins
Abstract

Metagenomic studies permit the exploration of microbial diversity in a defined habitat, and binning procedures enable phylogenomic analyses, taxon description, and even phenotypic characterizations in the absence of morphological evidence. Such lineages include asgard archaea, which were initially reported to represent archaea with eukaryotic cell complexity, although the first images of such an archaeon show simple cells with prokaryotic characteristics. However, these metagenome-assembled genomes (MAGs) might suffer from data quality problems not encountered in sequences from cultured organisms due to two common analytical procedures of bioinformatics: assembly of metagenomic sequences and binning of assembled sequences on the basis of innate sequence properties and abundance across samples. Consequently, genomic sequences of distantly related taxa, or domains, can in principle be assigned to the same MAG and result in chimeric sequences. The impacts of low-quality or chimeric MAGs on phylogenomic and metabolic prediction remain unknown. Debates that asgard archaeal data are contaminated with eukaryotic sequences are overshadowed by the lack of evidence indicating that individual asgard MAGs stem from the same chromosome. Here, we show that universal proteins including ribosomal proteins of asgard archaeal MAGs fail to meet the basic phylogenetic criterion fulfilled by genome sequences of cultured archaea investigated to date: These proteins do not share common evolutionary histories to the same extent as pure culture genomes do, pointing to a chimeric nature of asgard archaeal MAGs. Our analysis suggests that some asgard archaeal MAGs represent unnatural constructs, genome-like patchworks of genes resulting from assembly and/or the binning process. [ABSTRACT FROM AUTHOR]

Published
2021
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